Thomas Jefferson Univerity
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 4 Trials 
11 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Orloff, Marlana M
DAR-UM-2, NCT05987332: IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma

Recruiting
2/3
420
Europe, Canada, US, RoW
IDE196, Darovasertib, Crizotinib, XALKORI, Pembrolizumab, Keytruda, Ipilimumab, Yervoy, Nivolumab, Opdivo, Dacarbazine, DTIC-Dome
IDEAYA Biosciences
Metastatic Uveal Melanoma
01/27
01/28
NCT03472586: Ipilimumab and Nivolumab With Immunoembolization in Treating Participants With Metastatic Uveal Melanoma in the Liver

Active, not recruiting
2
14
US
Ipilimumab, Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody, BMS-734016, MDX-010, 720801, 477202-00-9, 732442, Nivolumab, 946414-94-4, BMS-936558, ONO-4538, Opdivo, Embolization Therapy
Sidney Kimmel Cancer Center at Thomas Jefferson University, Bristol-Myers Squibb
Metastatic Malignant Neoplasm in the Liver, Metastatic Uveal Melanoma, Stage IV Uveal Melanoma AJCC v7
12/22
12/24
KEYNOTE-C86, NCT04993677 / 2021-002037-42: A Study of SEA-CD40 Given With Other Drugs in Cancers

Active, not recruiting
2
77
Europe, Canada, US
SEA-CD40, pembrolizumab (KEYTRUDA®), pemetrexed, Alimta, carboplatin, Paraplatin
Seagen Inc., Merck Sharp & Dohme LLC
Melanoma, Carcinoma, Non-Small- Cell Lung
01/24
10/25
IDE196-009, NCT05907954: (Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma

Recruiting
2
82
Europe, Canada, US, RoW
Darovasertib, IDE196, LXS196
IDEAYA Biosciences
Uveal Melanoma
01/26
01/29
NCT02535078 / 2015-002971-12: Phase 1b/2 Study of the Combination of IMCgp100 With Durvalumab and/or Tremelimumab in Advanced Cutaneous Melanoma

Checkmark OS data from trial in combination with durvalumab and tremelimumab for cutaneous melanoma
Jun 2022 - Jun 2022: OS data from trial in combination with durvalumab and tremelimumab for cutaneous melanoma
Withdrawn
1/2
113
US
Tebentafusp (IMCgp100)
Immunocore Ltd, AstraZeneca
Malignant Melanoma
06/23
09/23
Keynote MK-3475-B66, NCT03611868: A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors

Recruiting
1/2
230
US, RoW
Phase 1b: APG-115+pembrolizumab, KEYTRUDA®
Ascentage Pharma Group Inc., Merck Sharp & Dohme LLC
Unresectable or Metastatic Melanoma or Advanced Solid Tumors, Melanoma, Uveal Melanoma, P53 Mutation, MDM2 Gene Mutation, Cutaneous Melanoma, Mucosal Melanoma, Malignant Peripheral Nerve Sheath Tumors (MPNST)
12/24
03/25
MUM, NCT03947385: Study of IDE196 in Patients with Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

Jan 2023 - Dec 2023: Data from P1/2 trial in combination with crizotinib for treatment of MUM
Checkmark Interim data from trial in combination with crizotinib for metastatic uveal melanoma
Sep 2022 - Sep 2022: Interim data from trial in combination with crizotinib for metastatic uveal melanoma
Checkmark From trial in combination with darovasertib for uveal melanoma
Dec 2021 - Dec 2021: From trial in combination with darovasertib for uveal melanoma
Recruiting
1/2
341
Canada, US, RoW
IDE196, Protein Kinase C (PKC) Inhibitor, Binimetinib, MEKTOVI, Crizotinib, XALKORI
IDEAYA Biosciences
Metastatic Uveal Melanoma, Cutaneous Melanoma, Colorectal Cancer, Other Solid Tumors
12/26
03/27
NCT06626516: Tebentafusp-tebn With LDT in Metastatic UM

Not yet recruiting
1/2
109
US
Tebentafusp-Tebn, kimmtrak, IMCgp100, GM-CSF (Sargramostim), yeast-derived recombinant human GM-CSF, Leukine, Hepatic Immunoembolization, GM-CSF, Sargramostim, BCNU, Carmustine, BiCNU, bis-chloroethylnitrosourea, Hepatic Chemoembolization, 1,3-bis [2-chloroethyl]-1-nitrosourea
Thomas Jefferson University, Sidney Kimmel Cancer Center at Thomas Jefferson University
Metastatic Uveal Melanoma
07/26
08/26
NCT04879017: FHD-286 in Subjects With Metastatic Uveal Melanoma

Terminated
1
76
Europe, US
FHD-286
Foghorn Therapeutics Inc.
Metastatic Uveal Melanoma
11/23
11/23
PERIO-01, NCT04935229: Intrahepatic Delivery of SD-101 by Pressure-Enabled Regional Immuno-oncology (PERIO), With Checkpoint Blockade in Adults With Metastatic Uveal Melanoma

Hourglass Jul 2024 - Dec 2024 : P1 data from PERIO-01 trial for uveal melanoma liver metastases
Active, not recruiting
1
80
US
SD-101, Nivolumab, Opdivo, Ipilimumab, Yervoy, Nivolumab and Relatlimab, Opdualag
TriSalus Life Sciences, Inc.
Metastatic Uveal Melanoma in the Liver
09/24
01/25
OMNi, NCT04588662: A Prospective Natural History Study in Uveal Melanoma

Recruiting
N/A
700
Europe, Canada, US, RoW
Columbia University
Uveal Melanoma
07/26
07/26

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