| Enrolling by invitation | 4 | 1500 | Canada, US | Subanesthetic dose intravenous ketamine (KET), Electroconvulsive therapy (ECT) | Brigham and Women's Hospital, Johns Hopkins University, University of Pittsburgh, Baylor College of Medicine, University of Arizona, The Cleveland Clinic, Icahn School of Medicine at Mount Sinai, Washington University School of Medicine, The Center for Addiction and Mental Health (University of Toronto), The University of Texas Health Science Center, Houston | Acute Suicidal Depression (ASD) | 01/30 | 03/30 | | |