| DeFronzo, Ralph A |
NCT02911792: Effect of Farxiga on Renal Function and Size in Type 2 Diabetic Patients With Hyperfiltration |
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| Completed | 4 | 72 | US | Dapagliflozin, Farxiga, Metformin, Metformin-XR, Glipizide 5 MG | The University of Texas Health Science Center at San Antonio, AstraZeneca | Diabetes Mellitus, Type 2 | 07/23 | 07/23 | | |
NCT01107717: Durability of Combination Therapy With Exenatide/Pioglitazone/Metformin vs. Conventional Therapy in New Onset T2DM |
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| Completed | 4 | 318 | US | metformin\pioglitazone\exenatide, metformin, glyburide and glargine | The University of Texas Health Science Center at San Antonio, American Diabetes Association, Amylin Pharmaceuticals, LLC., National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Diabetes | 02/23 | 02/23 | | |
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| Recruiting | 4 | 78 | US | Pioglitazone, Actos, Placebo, Placebo tablet | The University of Texas Health Science Center at San Antonio | Type 2 Diabetes Mellitus in Obese, Heart Failure With Preserved Ejection Fraction | 04/28 | 01/29 | | |
| Recruiting | 1 | 71 | US | Empagliflozin 25 MG Oral Tablet, jardiance, Placebo, Acipimox 250 Mg Oral Capsule | The University of Texas Health Science Center at San Antonio, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Type2diabetes, Heart Failure With Reduced Ejection Fraction | 11/26 | 03/27 | | |
NCT05093517: Effect of Novel Glucagon Receptor Antagonist REMD-477 on Glucose and Adipocyte Metabolism in T2DM |
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| Completed | 1 | 4 | US | REMD-477, Placebo Subcutaneous injection, Placebo | The University of Texas Health Science Center at San Antonio | Type 2 Diabetes, Glucose Tolerance Impaired, Insulin Sensitivity | 03/22 | 03/22 | | |
NCT05960656: SGLT2 Inhibitors, Ketogenesis, and Ketoacidosis |
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| Recruiting | 1 | 169 | US | Empagliflozin 25 MG, Jardiance, Placebo, Placebo for empagliflozin, Pioglitazone 30mg, Actos, Pioglitazone 30mg + Empagliflozin (25 mg), Actos/Jardiance | The University of Texas Health Science Center at San Antonio, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Type 2 Diabetes, Type 1 Diabetes | 06/27 | 06/27 | | |
| Completed | 1 | 10 | US | Glucagon Infusion, IV Glucagon, Saline, Normal saline | The University of Texas Health Science Center at San Antonio, South Texas Veterans Health Care System | Insulin Sensitivity | 11/23 | 11/23 | | |
NCT03560323: Ketones, Muscle Metabolism, and SGLT2 Inhibitors - Protocol 1 |
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| Recruiting | 1 | 78 | US | Beta-hydroxy-butyrate, Infusion of Beta-Hydroxy-Butyrate (B-OH-B) | The University of Texas Health Science Center at San Antonio, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Heart Failure, Type 2 Diabetes Mellitus | 10/26 | 02/27 | | |
NCT05057806: SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan |
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| Recruiting | 1 | 30 | US | Empagliflozin 25 MG, Jardiance, Placebo, Placebo for Empagliflozin | The University of Texas Health Science Center at San Antonio, Doris Duke Charitable Foundation, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Type2 Diabetes, Heart Failure With Preserved Ejection Fraction | 11/26 | 03/27 | | |
NCT03953963: Evaluation of Intra-Abdominal Fat Extraction Using HydraSolve T2D™ in Obese Subjects With Type 2 Diabetes |
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| Recruiting | N/A | 12 | US | HydraSolve T2D™ | Medality Medical | Diabetes Mellitus, Type 2, Insulin Resistance | 07/21 | 03/22 | | |
NCT04791787: Effect of Ketogenic Diet on Glucose Metabolism and Energy Expenditure in Type 2 Diabetes |
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| Completed | N/A | 35 | US | Standard weight maintaining diet, Weight maintaining isocaloric ketogenic diet, Beta-hydroxy butyrate, BHOB | The University of Texas Health Science Center at San Antonio | Glucose Metabolism Disorders (Including Diabetes Mellitus), Energy Supply; Deficiency, Type 2 Diabetes | 04/23 | 04/23 | | |
NCT02969798: Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT) |
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| Recruiting | N/A | 700 | US | Dapagliflozin, farxiga, Saxagliptin, onglyza, Pioglitazone, actos, Metformin, glucophage | The University of Texas Health Science Center at San Antonio, American Diabetes Association, AstraZeneca, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Diabetes Mellitus, Type 2, Impaired Glucose Tolerance (IGT), Impaired Fasting Glucose (IFG) | 03/26 | 07/27 | | |
NCT05867017: Long-Term Sequelae of SARS-COV-2 Infection: Diabetes Mellitus |
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| Recruiting | N/A | 213 | US | Measure of physiologic parameters | The University of Texas Health Science Center at San Antonio, National Heart, Lung, and Blood Institute (NHLBI) | COVID-19, Diabete Mellitus | 06/25 | 08/26 | | |
| Salehi, Marzieh |
NCT06706284: Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes |
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| Recruiting | 4 | 50 | US | Semaglutide Injectable Product, Ozempic, Placebo, Saline solution | Marzieh Salehi, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Spinal Cord Injuries, Type 2 Diabetes | 05/28 | 01/29 | | |
| Recruiting | 2 | 72 | Europe, US | Pasireotide Diaspartate, Pasireotide | RECORDATI GROUP | Post-Bariatric Hypoglycemia | 04/25 | 04/26 | | |
NCT01803451: Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass |
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| Recruiting | 1 | 80 | US | exendin-(9-39), no other name for exendin-(9-39), exendin -(9-39) | The University of Texas Health Science Center at San Antonio | Post-bariatric Surgery | 08/25 | 08/26 | | |
NCT00992901: Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery |
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| Recruiting | 1 | 160 | US | Exendin-(9-39), No other name for Exendin-(9-39), Atropine, Atropine sulfate, GLP-1 and GIP, No other names for GLP-1 and GIP. | The University of Texas Health Science Center at San Antonio | Post Bariatricsurgery, Hypoglycemia | 08/25 | 08/26 | | |
NCT02823665: The Effects of Bariatric Surgeries on Glucose Metabolism |
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| Recruiting | 1 | 200 | US | Exendin-(9-39), no other name for Exendin-(9-39), Atropine, Atropine sulfate | The University of Texas Health Science Center at San Antonio, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Post Bariatric Surgery, Gastric Bypass, Sleeve Gastrectomy, Hypoglycemia After Gastric Bypass | 08/25 | 08/26 | | |
NCT05867017: Long-Term Sequelae of SARS-COV-2 Infection: Diabetes Mellitus |
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| Recruiting | N/A | 213 | US | Measure of physiologic parameters | The University of Texas Health Science Center at San Antonio, National Heart, Lung, and Blood Institute (NHLBI) | COVID-19, Diabete Mellitus | 06/25 | 08/26 | | |
| Hansis-Diarte, Andrea |
NCT05305287: Quantifying Hepatic Mitochondrial Fluxes in Humans |
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| Recruiting | 4 | 60 | US | Pioglitazone, Actos, Placebo | The University of Texas Health Science Center at San Antonio, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Non-Alcoholic Fatty Liver Disease, Type 2 Diabetes, Mitochondrial Metabolism Disorders | 03/27 | 03/27 | | |
NCT01803451: Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass |
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| Recruiting | 1 | 80 | US | exendin-(9-39), no other name for exendin-(9-39), exendin -(9-39) | The University of Texas Health Science Center at San Antonio | Post-bariatric Surgery | 08/25 | 08/26 | | |
NCT00992901: Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery |
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| Recruiting | 1 | 160 | US | Exendin-(9-39), No other name for Exendin-(9-39), Atropine, Atropine sulfate, GLP-1 and GIP, No other names for GLP-1 and GIP. | The University of Texas Health Science Center at San Antonio | Post Bariatricsurgery, Hypoglycemia | 08/25 | 08/26 | | |
NCT02823665: The Effects of Bariatric Surgeries on Glucose Metabolism |
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| Recruiting | 1 | 200 | US | Exendin-(9-39), no other name for Exendin-(9-39), Atropine, Atropine sulfate | The University of Texas Health Science Center at San Antonio, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Post Bariatric Surgery, Gastric Bypass, Sleeve Gastrectomy, Hypoglycemia After Gastric Bypass | 08/25 | 08/26 | | |
NCT03953963: Evaluation of Intra-Abdominal Fat Extraction Using HydraSolve T2D™ in Obese Subjects With Type 2 Diabetes |
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| Recruiting | N/A | 12 | US | HydraSolve T2D™ | Medality Medical | Diabetes Mellitus, Type 2, Insulin Resistance | 07/21 | 03/22 | | |
NCT05867017: Long-Term Sequelae of SARS-COV-2 Infection: Diabetes Mellitus |
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| Recruiting | N/A | 213 | US | Measure of physiologic parameters | The University of Texas Health Science Center at San Antonio, National Heart, Lung, and Blood Institute (NHLBI) | COVID-19, Diabete Mellitus | 06/25 | 08/26 | | |
| Solis-Herrera, Carolina |
NCT04401904: SGLT2 Inhibition in Older Obese Adults With Pre-diabetes |
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| Completed | 1/2 | 20 | US | Dapagliflozin 10 mg, Farxiga, Nutritional counseling | The University of Texas Health Science Center at San Antonio, National Institute on Aging (NIA) | Aging | 09/22 | 09/22 | | |
| Recruiting | 1 | 64 | US | Placebo, Zebbo, Rybelsus Tablet, Semaglutide, Jardiance 25Mg Tablet, Empagliflozin, Metformin, Metformin Hydrochloride, Actos, Pioglitazone | The University of Texas Health Science Center at San Antonio, Baptist Health Foundation of San Antonio | Pre-Diabetes, Weight, Body, Cardiovascular Diseases | 07/27 | 07/27 | | |
NCT06108076: Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes |
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| Recruiting | 1 | 10 | US | Ketone Monoester (KE), DeltaG | The University of Texas Health Science Center at San Antonio, National Center for Advancing Translational Sciences (NCATS) | Type 2 Diabetes, Heart Failure, Reduced Ejection Fraction | 10/24 | 01/25 | | |
NCT03560323: Ketones, Muscle Metabolism, and SGLT2 Inhibitors - Protocol 1 |
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| Recruiting | 1 | 78 | US | Beta-hydroxy-butyrate, Infusion of Beta-Hydroxy-Butyrate (B-OH-B) | The University of Texas Health Science Center at San Antonio, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Heart Failure, Type 2 Diabetes Mellitus | 10/26 | 02/27 | | |
NCT05057806: SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan |
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| Recruiting | 1 | 30 | US | Empagliflozin 25 MG, Jardiance, Placebo, Placebo for Empagliflozin | The University of Texas Health Science Center at San Antonio, Doris Duke Charitable Foundation, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Type2 Diabetes, Heart Failure With Preserved Ejection Fraction | 11/26 | 03/27 | | |
NCT03953963: Evaluation of Intra-Abdominal Fat Extraction Using HydraSolve T2D™ in Obese Subjects With Type 2 Diabetes |
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| Recruiting | N/A | 12 | US | HydraSolve T2D™ | Medality Medical | Diabetes Mellitus, Type 2, Insulin Resistance | 07/21 | 03/22 | | |
| Neppala, Sivaram |
| Recruiting | 4 | 78 | US | Pioglitazone, Actos, Placebo, Placebo tablet | The University of Texas Health Science Center at San Antonio | Type 2 Diabetes Mellitus in Obese, Heart Failure With Preserved Ejection Fraction | 04/28 | 01/29 | | |
| Recruiting | 1 | 71 | US | Empagliflozin 25 MG Oral Tablet, jardiance, Placebo, Acipimox 250 Mg Oral Capsule | The University of Texas Health Science Center at San Antonio, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Type2diabetes, Heart Failure With Reduced Ejection Fraction | 11/26 | 03/27 | | |
NCT05057806: SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan |
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| Recruiting | 1 | 30 | US | Empagliflozin 25 MG, Jardiance, Placebo, Placebo for Empagliflozin | The University of Texas Health Science Center at San Antonio, Doris Duke Charitable Foundation, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Type2 Diabetes, Heart Failure With Preserved Ejection Fraction | 11/26 | 03/27 | | |
| Qin, Yuejuan |
NCT05057806: SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan |
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| Recruiting | 1 | 30 | US | Empagliflozin 25 MG, Jardiance, Placebo, Placebo for Empagliflozin | The University of Texas Health Science Center at San Antonio, Doris Duke Charitable Foundation, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Type2 Diabetes, Heart Failure With Preserved Ejection Fraction | 11/26 | 03/27 | | |
