| Fiedler, Walter |
NCT03897127: Study of Standard Intensive Chemotherapy Versus Intensive Chemotherapy with CPX-351 in Adult Patients with Newly Diagnosed AML and Intermediate- or Adverse Genetics |
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| Recruiting | 3 | 882 | Europe | Cytarabine, Daunorubicin, CPX-351 | University of Ulm, Jazz Pharmaceuticals | Acute Myeloid Leukemia | 06/27 | 06/27 | | |
NCT04628026: Phase III Study of Induction and Consolidation Chemotherapy With Venetoclax in Patients With Newly Diagnosed AML or MDS-EB-2 |
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| Recruiting | 3 | 650 | Europe | Venetoclax, Placebo, Standard chemotherapy, Autologous stem cell transplantation, Allogeneic stem cell transplantation | University of Ulm, Stichting Hemato-Oncologie voor Volwassenen Nederland | Acute Myeloid Leukemia, Myelodysplastic Syndromes | 02/25 | 02/31 | | |
| Completed | 2 | 52 | Europe | Blinatumomab, blincyto | Goethe University | B-Precursor ALL | 01/24 | 01/24 | | |
NCT06648889: Isatuximab in Adult Patients with Cytologic or Molecular Relapsed/refractory CD38 Positive T-cell Acute Lymphoblastic Leukemia |
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| Recruiting | 2 | 40 | Europe | Isatuximab, Bortezomib | Goethe University, Sanofi | T-ALL | 02/28 | 08/28 | | |
GMALL-BLIVEN, NCT05182385: Venetoclax in Addition to Blinatumomab in Adult Patients With Relapsed/Refractory B Cell Precursor Acute Lymphoblastic Leukemia Relapsed/Refractory B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) |
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| Recruiting | 1/2 | 39 | Europe | Blinatumomab, blincyto, Venetoclax, Venclyxto | Goethe University, University Hospital Schleswig-Holstein | ALL, Recurrent, Adult | 06/25 | 12/25 | | |
| Recruiting | 1/2 | 413 | Europe, Canada, US, RoW | revumenib, SNDX-5613, cobicistat | Syndax Pharmaceuticals, Syndax Pharmaceuticals, Inc | Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Mixed Lineage Acute Leukemia, Mixed Phenotype Acute Leukemia, Acute Leukemia of Ambiguous Lineage | 12/27 | 12/27 | | |
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| Recruiting | 1 | 94 | Europe | IL12-L19L19, Dodekin | Philogen S.p.A. | Advanced Solid Tumor, Metastatic Solid Tumor | 12/25 | 12/25 | | |
NCT04230265: Dose-escalating Trial With UniCAR02-T Cells and CD123 Target Module (TM123) in Patients With Hematologic and Lymphatic Malignancies |
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| Recruiting | 1 | 90 | Europe | Cyclophosphamide (Non-IMP), Fludarabine (Non-IMP), TM123 (IMP), UniCAR02-T (IMP) | AvenCell Europe GmbH, PHARMALOG Institut für klinische Forschung GmbH | Acute Myeloid Leukemia (AML) | 05/25 | 09/25 | | |
AMLSG BiO, NCT01252485: Registry Study on Patient Characteristics, Biological Disease Profile and Clinical Outcome in Acute Myeloid Leukemia and Related Neoplasms - the Biology and Outcome (BiO)-Project |
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| Recruiting | N/A | 50000 | Europe | | University of Ulm | Acute Myeloid Leukemia (AML), MDS/AML | 12/44 | 12/44 | | |
| Rutkowski, Stefan |
| Recruiting | 2/3 | 536 | Europe, RoW | 16 weeks of VEC + CDDP, Vincristine, Etoposide, Cyclophosphamide, Cisplatin, VEC + HD-MTX, Methotrexate, Chemotherapy + Valproate, Carboplatin, Valproate, Conformal radiotherapy, VEC, Chemotherapy, conformal radiotherapy +/- boost | Centre Leon Berard | Childhood Ependymoma | 06/28 | 08/31 | | |
| Suspended | N/A | 500 | Europe | | Universitätsklinikum Hamburg-Eppendorf | Childhood Brain Tumor | 12/29 | 12/29 | | |
| Rief, Winfried |
NCT04461548: Micro-interventions Aiming to Optimize Expectations or Self-compassion to Improve Well-being/Reduce Stress and Their Differential Effects |
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| Completed | N/A | 181 | Europe | Thinking, writing and imagining | Philipps University Marburg Medical Center | no Specific Clincal Condition Required (Focus is on Persons Who Are Feeling Stressed or Want to Improve Their Wellbeing) | 10/20 | 10/20 | | |
BestBPS, NCT04753801: What Are the Ingredients for the Best Form of the Best Possible Self (BPS) Intervention? |
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| Completed | N/A | 181 | Europe | Thinking, writing and imagination | Philipps University Marburg Medical Center | Healthy Participants | 03/21 | 03/21 | | |
NCT04669379: Is an Online-tool Capable of Improving Patients' Outcomes After Surgery? |
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| Terminated | N/A | 29 | Europe | EXPECT: Preoperative optimization of patient's expectations | Philipps University Marburg Medical Center | Patients Undergoing Surgery | 11/22 | 11/22 | | |
| Completed | N/A | 89 | Europe | EXPECT: Preoperative optimization of cardiac valve patient's expectations | Philipps University Marburg Medical Center, Heart Centre Rotenburg, Justus-Liebig University Gießen Medical Center | Cardiac Valve Disease | 11/22 | 07/23 | | |
NCT05402150: An Online Intervention Targeting Depression and Low Reward Sensitivity |
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| Completed | N/A | 224 | Europe | Behavioral Activation, Mindulness and Gratitude, Combination of Behavioral Activation and Mindfulness and Gratitude | Philipps University Marburg Medical Center | Depression Mild, Depression Moderate | 05/23 | 09/23 | | |
| Completed | N/A | 224 | Europe | Behavioral Activation, Mindfulness and Gratitude, Combination of Behavioral Activation and Mindfulness and Gratitude | Philipps University Marburg Medical Center | Depression Mild, Depression Moderate | 05/23 | 09/23 | | |
| Completed | N/A | 81 | Europe | Expectation-focused online intervention | Philipps University Marburg Medical Center | Expectations | 03/24 | 03/24 | | |
NCT05826886: The Effect of Video-based Testimonials About Psychotherapy on Treatment Expectations and a Short Online Intervention |
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| Completed | N/A | 81 | Europe | Emotional Writing, Expressive Writing | Philipps University Marburg Medical Center | Health Care Utilization | 10/23 | 10/23 | | |
| Active, not recruiting | N/A | 399 | Europe, US, RoW | Standard Exposure, Stress Management Training, Enhanced Exposure | University of Texas at Austin, University of North Carolina, Chapel Hill, University of Colorado, Boulder, University of Miami, University of Mississippi, Oxford, Ruhr University of Bochum, Boston University, Fordham University, The University of New South Wales, Southern Methodist University, Institute of Behavioral-Therapy and -Medicine at the Philipps University Marburg, Technische Universität Dresden, Curtin University, Hebrew University of Jerusalem, University of Göttingen | Elevated Anxiety Sensitivity | 09/24 | 09/24 | | |
NCT04719663: The Modulatory Role of Communicated Treatment Rationale on Treatment Expectation Effects in Depression. |
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| Completed | N/A | 150 | Europe | Biological illness and treatment rationale, Psychological illness and treatment rationale, Active pharmacological placebo, Active psychological placebo | Philipps University Marburg Medical Center, Psychotherapie-Ambulanz Marburg e.V. | Condition: Major Depressive Disorder (MDD) | 09/23 | 09/23 | | |
NCT06069193: Enhancing Treatment Outcomes: The Impact of Physical Touch in Back and Neck Pain Management |
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| Recruiting | N/A | 120 | Europe | Touch Intervention, Control | Philipps University Marburg Medical Center | Pain | 09/24 | 12/24 | | |
| Recruiting | N/A | 380 | Europe | Exposure therapy, Cognitive behavioral therapy | University of Kaiserslautern-Landau | Chronic Low Back Pain | 10/25 | 02/26 | | |
| Mahner, Sven |
SHAPE, NCT01658930: Radical Versus Simple Hysterectomy and Pelvic Node Dissection With Low-risk Early Stage Cervical Cancer |
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| Completed | N/A | 700 | Europe, Canada, RoW | Radical Hysterectomy + pelvic lymph node dissection, Simple hysterectomy + pelvic lymph node dissection | Canadian Cancer Trials Group, Gynecologic Cancer Intergroup (GCIG), Canadian Institutes of Health Research (CIHR), Korean Gynecologic Oncology Group, Dutch Gynecologic Oncology Group, Cancer Trials Ireland, Arbeitsgemeinschaft Gynaekologische Onkologie Austria, Belgium Gynecologic Oncology Group, Group d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens, Institute of Cancer Research, United Kingdom, Shanghai Cancer Centre Deptartment of Gynecologic Oncology Fudan University, Hertzen Moscow Scientific Research Institute of Oncology, Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom Germany, Institut Claudius Regaud - Institute Universitaire du Cancer de Toulouse - Oncopole | Cervical Cancer | 03/23 | 11/24 | | |
| Active, not recruiting | N/A | 797 | Europe, US | PDS (Primary Debulkdung Surgery), 6 cycles of standard chemotherapy, Timing of surgery after 3 cycles of standard NACT, IDS, IDS, 3 cycles of standard chemotherapy | AGO Study Group | Ovarian Cancer | 12/24 | 02/25 | | |
| Kroeger, Nicolaus |
NCT04232241: Matched Unrelated vs. Haploidentical Donor for Allogeneic Stem Cell Transplantation in Patients With Acute Leukemia |
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| Recruiting | 2 | 440 | Europe, RoW | Allogeneic Stem Cell Transplantation | Universitätsklinikum Hamburg-Eppendorf, DKMS Stiftung Leben Spenden, Clinical Trial Center North (CTC North GmbH & Co. KG) | Acute Myeloid Leukemia in Remission, Acute Lymphoblastic Leukemia in Remission, Myelodysplastic Syndromes | 11/22 | 11/24 | | |
| Rösch, Thomas |
| Terminated | N/A | 110 | Europe | en-bloc resection, endoscopic submucosal dissection, ESD, piecemeal resection, piecemeal polypectomy, piecemeal endoscopic mucosal resection, piecemeal EMR | Universitätsklinikum Hamburg-Eppendorf | Colorectal Adenoma With Mild Dysplasia, Colorectal Adenoma With Severe Dysplasia, Colorectal Adenomatous Polyp, Colorectal Low Grade Intraepithelial Neoplasia, Colorectal High Grade Intraepithelial Neoplasia | 05/21 | 05/22 | | |
Endocuff, NCT03442738: A Prospective Randomized Comparison of the Adenoma Detection Rate With a Disposable Cap (ENDOCUFF VISION®) |
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| Completed | N/A | 1382 | Europe | Endocuff group | Universitätsklinikum Hamburg-Eppendorf, Norgine | Adenoma Detection Rate | 09/21 | 09/22 | | |
EFFEKTRA, NCT04898803: How Effective Can a Simulator-Based Training Course For Beginners In Endoscopy Be Made? |
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| Completed | N/A | 32 | Europe | conventional DGVS training, extended simulator training | Universitätsklinikum Hamburg-Eppendorf, Olympus Deutschland GmbH | Physicians Gastroscopy Training | 12/22 | 12/22 | | |
| Terminated | N/A | 96 | Europe | use of EndoClot | Universitätsklinikum Hamburg-Eppendorf | Wound Endoscopical, Colon, After Polyp Resection, Colon | 01/23 | 01/23 | | |
coldAPC, NCT06435533: Cold Atmospheric Plasma for the Endoscopic Treatment of Duodenal Polyps in Patients With Familial Adenomatous Polyposis |
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| Recruiting | N/A | 10 | Europe | low energy argonplasma coagulation, cold APC | Universitätsklinikum Hamburg-Eppendorf | Adenomatous Polyposis Coli, Familial Adenomatous Polyposis, Duodenal Adenoma | 01/25 | 03/25 | | |
| Completed | N/A | 15 | Europe | 1.1mm flexible Cryoprobe SU, Comparator: SpyBite Max Forceps | Erbe Elektromedizin GmbH | Neoplasms, Bile Duct | 08/24 | 12/24 | | |
Fuji AI, NCT04894708: Study on the Use of Artificial Intelligence (Fujifilm) for Polyp Detection in Colonoscopy |
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| Recruiting | N/A | 1572 | Europe | colonoscopy | Universitätsklinikum Hamburg-Eppendorf, FUJIFILM Deutschland, Branch office of FUJIFILM Europe GmbH | Screening Colonoscopy, Colonoscopic Control After Polypectomy, Suspected Colon Polyps | 05/24 | 09/24 | | |
| Suspended | N/A | 200 | Europe | removal of submucosal gastric tumor preferably by Full Thickness Resection Device (FTRD), Endoscopic submucosal dissection (ESD) | Universitätsklinikum Hamburg-Eppendorf, Ovesco Endoscopy AG | Submucosal Tumor of Stomach | 11/24 | 02/25 | | |
| Recruiting | N/A | 407 | Europe, US | Endoscopic mucosal resection, EMR, Piecemeal EMR, Endoscopic submucosal dissection, ESD | Universitätsklinikum Hamburg-Eppendorf | Barrett Esophagus, Barrett Adenocarcinoma, Esophagus Neoplasm | 10/25 | 10/25 | | |
| Reuter, Daniel |
| Recruiting | 2 | 142 | Europe | ARTICE | Artcline GmbH, Zentrum für Klinische Studien Jena, CRO Kottmann | Sepsis, Severe | 12/24 | 05/25 | | |
| Completed | N/A | 380 | Europe | Individualized Goal Directed Therapy, Control Group | Universitätsklinikum Hamburg-Eppendorf, University of Giessen, University of Rostock | Hemodynamic Instability, Cardiac Output, High, Peroperative Complication | 03/23 | 08/23 | | |
ReActIF- LTO, NCT06143137: Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy - Observational Long-term Outcome Follow up |
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| Recruiting | N/A | 142 | Europe | | Artcline GmbH, ZKS Jena | Severe Sepsis | 12/29 | 02/30 | | |
PROCYSS, NCT04963920: A RCT to Assess the Performance of CytoSorb for Shock Reversal in Patients With Vasoplegic Septic Shock |
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| Recruiting | N/A | 260 | Europe | Cytosorb® 300 ml | CytoSorbents Europe GmbH, BRAHMS GmbH, MedInnovation GmbH | Septic Shock | 02/25 | 05/25 | | |
| Kluge, Stefan |
| Completed | 3 | 140 | Europe | Anticoagulation Agents (Edoxaban and/or high dose LMWH), Low dose Low molecular weight heparin or Placebo | Universitätsklinikum Hamburg-Eppendorf | Covid19 | 09/22 | 01/23 | | |
| Recruiting | 3 | 710 | Europe | Acyclovir, Aciclovir | Jena University Hospital | Pneumonia, Viral, Ventilator Associated Pneumonia, Community-acquired Pneumonia, Herpes Simplex, Hospital-acquired Pneumonia | 07/26 | 12/26 | | |
| Terminated | 2 | 16 | Europe | Adrecizumab (HAM 8101), Placebo, Saline | Universitätsklinikum Hamburg-Eppendorf | COVID-19 | 08/23 | 11/23 | | |
| Recruiting | 2 | 200 | Europe | Pentaglobin®/Standard of Care | RWTH Aachen University, Biotest | Peritonitis, Sepsis, Septic Shock | 09/27 | 03/28 | | |
| Recruiting | N/A | 1000 | Europe | | Infectopharm Arzneimittel GmbH, INPADS GmbH, Dr. Oestreich + Partner GmbH | Bacterial Infections, Bone Diseases, Infectious, Osteomyelitis, Central Nervous System Bacterial Infections, Meningitis, Bacterial, Encephalitis, Brain Abscess, Urinary Tract Infections, Respiratory Tract Infections, Pneumonia, Bacterial, Skin Diseases, Bacterial, Soft Tissue Infections, Intraabdominal Infections, Sepsis, Bacteremia, Endocarditis, Bacterial | 12/30 | 12/30 | | |
| Recruiting | N/A | 32 | Europe | CytoSorb-Therapy | Universitätsklinikum Hamburg-Eppendorf, CytoSorbents, Inc | Septic Shock | 12/23 | 12/23 | | |
multiECCO2R, NCT04871893: Safety and Efficacy Evaluation of CO2 Removal in Combination with Continuous Veno-Venous Hemodialysis/Hemodiafiltration Therapy |
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| Recruiting | N/A | 40 | Europe | multiECCO2R blood-gas exchanger | Fresenius Medical Care Deutschland GmbH, CERES GmbH | Acute Lung Injury, Acute Kidney Injury, Hypercapnia, Covid19 | 12/24 | 03/25 | | |
| Completed | N/A | 126 | Europe | nasotracheal intubation, NTI, orotracheal intubation, OTI | Universitätsklinikum Hamburg-Eppendorf | Tracheal Intubation Morbidity, Critical Care | 11/24 | 11/24 | | |
PROCYSS, NCT04963920: A RCT to Assess the Performance of CytoSorb for Shock Reversal in Patients With Vasoplegic Septic Shock |
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| Recruiting | N/A | 260 | Europe | Cytosorb® 300 ml | CytoSorbents Europe GmbH, BRAHMS GmbH, MedInnovation GmbH | Septic Shock | 02/25 | 05/25 | | |
| Recruiting | N/A | 360 | Europe | Pharyngeal Electrical Stimulation (PES), Phagenyx | Phagenesis Ltd., NAMSA, Cytel Inc. | Dysphagia | 09/25 | 12/25 | | |
| Thomalla, Götz |
| Completed | 3 | 850 | Europe, Canada, US, RoW | Placebo, Nerinetide, NA-1 | NoNO Inc., University of Calgary | Stroke, Acute | 08/23 | 08/23 | | |
MOSES, NCT03961334: MidregiOnal Proatrial Natriuretic Peptide to Guide SEcondary Stroke Prevention |
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| Recruiting | 3 | 620 | Europe | Dabigatran, Pradaxa, Apixaban, Eliquis, Edoxaban, Lixiana, Aspirin, Aspirin cardio, Clopidogrel | University of Zurich, Swiss National Science Foundation | Stroke, Ischemic | 01/25 | 01/26 | | |
TECNO, NCT05499832: Safety and Efficacy of Intra-arterial Tenecteplase for Noncomplete Reperfusion of Intracranial Occlusions |
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| Recruiting | 3 | 156 | Europe | Tenecteplase | Insel Gruppe AG, University Hospital Bern | Ischemic Stroke | 07/25 | 10/25 | | |
| Not yet recruiting | 3 | 1746 | NA | Medical or interventional therapy for rhythm control in atrial fibrillation (antiarrhythmic drugs, ablation, electric cardio version), Usual care for atrial fibrillation | Universitätsklinikum Hamburg-Eppendorf, University Heart & Vascular Center Hamburg, Department of Cardiology, Department of Neurology, Royal Melbourne Hospital, Melbourne Heart Centre, Royal Melbourne Hospital, Hotchkiss Brain Institute, University of Calgary, Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, UMC Utrecht, Edinburgh Clinical Trials Unit, Cerebrovascular Research Group, Centre for Clinical Brain Sciences, University of Edinburgh, Department of Cardiovascular Sciences, University of Leicester British Heart Foundation Cardiovascular Research Centre, Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, CTC-NORTH, Stroke Alliance for Europe (SAFE), Kompetenznetz Vorhofflimmern e.V. (AFNET) | Acute Ischemic Stroke, Atrial Fibrillation | 09/28 | 03/29 | | |
ELAN, NCT03148457: Early Versus Late Initiation of Direct Oral Anticoagulants in Post-ischaemic Stroke Patients With Atrial fibrillatioN (): an International, Multicentre, Randomised-controlled, Two-arm, Assessor-blinded Trial |
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| Completed | N/A | 2013 | Europe, Japan, RoW | Early treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®), Late treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®) | Insel Gruppe AG, University Hospital Bern | Ischaemic Stroke | 12/22 | 05/23 | | |
StroCare, NCT04159324: - Optimised Cross-sectoral,Coordinated Treatment of Stroke Patients With Patient-orientated Outcome Measurement |
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| Completed | N/A | 409 | Europe | optimized cross-sectoral, structured and coordinated treatment pathway that integrates a patient-centred outcome evaluation | Universitätsklinikum Hamburg-Eppendorf, Albertinen Krankenhaus gGmbH, Elbe Kliniken Stade-Buxtehude GmbH, Reha Centrum Hamburg GmbH, Klinikum Bad Bramstedt GmbH, MediClin Klinikum Soltau GmbH, VAMED Klinik Geesthacht, VAMED Rehaklinik Damp, BARMER Krankenkasse, Lohmann und Birkner medizinisches ServiceCenter GmbH, Forcare GmbH | Stroke | 12/23 | 12/23 | | |
Tension, NCT03094715: Efficacy and Safety of Thrombectomy in Stroke With Extended Lesion and Extended Time Window |
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| Terminated | N/A | 253 | Europe, Canada, RoW | Thrombectomy, Mechanical thrombectomy, Best medical care, Control group | University Hospital Heidelberg, Karolinska University Hospital, Eppdata GmbH Hamburg, Germany, Aarhus University Hospital, Medical University Innsbruck, Groupe Hospitalier Pitie-Salpetriere, Oslo University Hospital, University Hospital, Martin, Charles University, Czech Republic, Hospices Civils de Lyon, CHU de Reims, Epidemiological and Clinical Research Information Network, STROKE ALLIANCE FOR EUROPE, International Consortium for Health Outcome Measurement, Inc., Europan Society for Minimally Invasive Neurological Therapy, Universitätsklinikum Hamburg-Eppendorf | Stroke, Acute, Cerebral Stroke, Cerebrovascular Stroke, Apoplexy; Brain | 05/23 | 11/23 | | |
DISTAL, NCT05029414: EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke |
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| Active, not recruiting | N/A | 543 | Europe, RoW | Endovascular Therapy | University Hospital, Basel, Switzerland, Swiss National Fund for Scientific Research, Stryker Neurovascular, Penumbra Inc., Medtronic, Phenox GmbH, Rapid Medical, Gottfried und Julia Bangerter-Rhyner-Stiftung | Acute Ischemic Stroke | 10/24 | 06/25 | | |
| Recruiting | N/A | 150 | Europe | Credo® Stent, NeuroSpeed® PTA balloon catheter | Acandis GmbH | Intracranial Stenosis | 03/25 | 10/25 | | |
| Recruiting | N/A | 10000 | Europe | telephone call d90 | Universitätsklinikum Hamburg-Eppendorf, University Hospital of Cologne, Klinikum rechts der Isar, Technical University of Munich, RWTH Aachen University, University Hospital Tuebingen, Charite University, Berlin, Germany, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Sana Klinikum Offenbach, Goethe University, Klinikum Dortmund, KRH Klinikum Nordstadt, Asklepios Klinik Altona, Klinikum Altenburger Land, Klinikum Stadt Hanau, Klinikum Lüneburg, Ludwig-Maximilians - University of Munich, University of Göttingen, Krankenhaus Buchholz, Klinikum Osnabrück, Wuerzburg University Hospital, University of Giessen and Marburg, Sana Kliniken Lübeck, Mühlenkreiskliniken Minden, radprax MVZ Nordrhein, University Hospital Muenster, University Medical Center Rostock, Asklepios Klinik Wandsbek, Elbe Kliniken, Städtische Klinikum Braunschweig, Allgemeines Krankenhaus Celle, Bezirkskrankenhaus Günzburg, Klinikum Bremen-Mitte, gGmbH, University Medical Center Mainz, Klinikum Köln-Merheim, University Hospital, Bonn | Acute Ischemic Stroke | 06/27 | 06/27 | | |
Find-AF2, NCT04371055: Intensive Rhythm Monitoring to Decrease Ischemic Stroke and Systemic Embolism - the Find-AF 2 Study |
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| Recruiting | N/A | 5200 | Europe | 7-day Holter ECG, Implantable cardiac monitor, Standard of care | University of Leipzig, Johannes Gutenberg University Mainz | Ischemic Stroke, Atrial Fibrillation | 06/26 | 12/26 | | |
CLEARANCE, NCT04298723: Comparison of LAA-Closure vs Oral Anticoagulation in Patients With NVAF and Status Post Intracranial Bleeding. |
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| Recruiting | N/A | 530 | Europe | Percutaneous closure of the LAA (Watchman / Watchman FLX) | Jena University Hospital | Atrial Fibrillation (AF), Intracranial Bleed | 06/27 | 06/27 | | |
| Moritz, Steffen |
| Recruiting | N/A | 180 | Europe | MAC-cbt group treatment for adult ADHD, Jacobson | Peter Tonn, Universitätsklinikum Hamburg-Eppendorf | Psychotherapy | 04/22 | 12/22 | | |
| Not yet recruiting | N/A | 252 | Europe, RoW | Psychological treatment (P-MCT), Psychological treatment (MCT) | Polish Academy of Sciences, Fundació Sant Joan de Déu, Universitätsklinikum Hamburg-Eppendorf, University Hospitals of Strasbourg, Universitat Politècnica de Catalunya, Universidad de Valparaiso | Schizophrenia, Psychosis, Schizophrenia Spectrum and Other Psychotic Disorders | 05/26 | 05/26 | | |
| Lambert, Martin |
| Completed | N/A | 1419 | Europe | ≥ 1 potential risk factor for BD, depressive syndrome, ADHD | Technische Universität Dresden, German Federal Ministry of Education and Research, Charite University, Berlin, Germany, Ruhr University of Bochum, Goethe University, Universitätsklinikum Hamburg-Eppendorf, Philipps University Marburg Medical Center, University Hospital Tuebingen, Vivantes Hospital am Urban, Berlin | Bipolar Disorder | 10/20 | 10/20 | | |
CARE, NCT05813080: Computer-assisted Risk Evaluation in the Early Detection of Psychotic Disorders |
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| Recruiting | N/A | 436 | Europe | "pronia.ai" medical device for high risk psychosis prognosis, Treatment-as-usual (TAU) | Heinrich-Heine University, Duesseldorf | Psychotic Disorders, Prevention | 12/24 | 03/25 | | |
| Recruiting | N/A | 400 | Europe | Integrated care | Universitätsklinikum Hamburg-Eppendorf | Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder, Delusional Disorder, Psychotic Disorder NOS, Bipolar Disorder, Severe Major Depression With Psychotic Features | 01/25 | 12/25 | | |
| Normand, Charline |
| Recruiting | 2/3 | 536 | Europe, RoW | 16 weeks of VEC + CDDP, Vincristine, Etoposide, Cyclophosphamide, Cisplatin, VEC + HD-MTX, Methotrexate, Chemotherapy + Valproate, Carboplatin, Valproate, Conformal radiotherapy, VEC, Chemotherapy, conformal radiotherapy +/- boost | Centre Leon Berard | Childhood Ependymoma | 06/28 | 08/31 | | |
| Kröger, Nicolaus |
AlloRelapseMM, NCT05675319: Allogeneic Stem Cell Transplantation vs. Conventional Therapy as Salvage Therapy for Relapsed / Progressive Patients With Multiple Myeloma After First-line Therapy |
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| Recruiting | 3 | 482 | Europe | Allogeneic Stem Cells, carfilzomib/lenalidomide/dexamethasone (KRD), elotuzumab/lenalidomide/dexamethasone (ERD), daratumumab/bortezomib/dexamethasone (DVD), daratumumab/lenalidomide/dexamethasone (DRD), ixazomib/lenalidomide/dexamethasone (IRD), pomalidomide/bortezomib/dexamethasone (PVD), carfilzomib/daratumumab/dexamethasone (KDD), Autologous Stem Cells, daratumumab/pomalidomide/dexamethasone (DPD), isatuximab/carfilzomib/dexamethasone (Isa-KD), selinexor/bortezomib/dexamethasone (SVD) | Universitätsklinikum Hamburg-Eppendorf, Gemeinsamer Bundesausschuss (G-BA), Staburo GmbH | Multiple Myeloma | 03/28 | 03/33 | | |
NCT04232241: Matched Unrelated vs. Haploidentical Donor for Allogeneic Stem Cell Transplantation in Patients With Acute Leukemia |
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| Recruiting | 2 | 440 | Europe, RoW | Allogeneic Stem Cell Transplantation | Universitätsklinikum Hamburg-Eppendorf, DKMS Stiftung Leben Spenden, Clinical Trial Center North (CTC North GmbH & Co. KG) | Acute Myeloid Leukemia in Remission, Acute Lymphoblastic Leukemia in Remission, Myelodysplastic Syndromes | 11/22 | 11/24 | | |
NCT04291261: Extracorporal Photopheresis with UVADEX Plus Standard Steroid Treatment for High Risk Acute Graft-versus-host Disease |
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| Completed | 2 | 24 | Europe | Uvadex | Universitätsklinikum Hamburg-Eppendorf, Therakos, University Medical Center Regensburg, Arbeitskreis Klinische Forschung PD Dr. med. Seiler GmbH | Acute-graft-versus-host Disease | 06/24 | 06/24 | | |
| Active, not recruiting | 2 | 37 | Europe | Cyclophosphamide, Endoxan | Universitätsklinikum Hamburg-Eppendorf, Riemser, Clinical Trial Center North (CTC North GmbH & Co. KG) | Multiple Myeloma | 07/23 | 07/24 | | |
NCT03333187: Ruxolitinib vs Allogeneic SCT for Patients With Myelofibrosis According to Donor Availability |
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| Active, not recruiting | 2 | 87 | Europe | Allogeneic stem cell transplantation, Ruxolitinib continuous therapy, Jakavi | Universitätsklinikum Hamburg-Eppendorf, Novartis, Clinical Trial Center North (CTC North GmbH & Co. KG) | Bone Marrow Fibrosis | 10/24 | 10/25 | | |
| Zapf, Antonia |
NCT06324188: Early Atrial Fibrillation Ablation for Stroke Prevention in Patients with High Comorbidity Burden (EASThigh-AFNET 11) |
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| Recruiting | N/A | 2312 | Europe, Canada, RoW | Early atrial fibrillation ablation, Usual Care | Atrial Fibrillation Network | Atrial Fibrillation | 02/30 | 05/30 | | |
| Böger, Rainer H |
PROSA, NCT06265623: Intermittent Hypoxemia, Lung Function Decline, Morbidity, and Mortality in COPD ( Study). |
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| Not yet recruiting | N/A | 148 | Europe | No active intervention, but observational follow-up | Universitätsklinikum Hamburg-Eppendorf | Chronic Obstructive Pulmonary Disease (COPD) | 09/28 | 09/29 | | |
| Debus, Sebastian |
| Terminated | 4 | 294 | Europe | ACT guided heparinization, 5 000 IU of heparin | Dijklander Ziekenhuis, ZonMw: The Netherlands Organisation for Health Research and Development, Amsterdam UMC, location VUmc, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Abdominal Aortic Aneurysm, Surgery, Arterial Disease | 04/24 | 04/24 | | |
| Active, not recruiting | N/A | 3638 | Europe, Canada, Japan, US, RoW | CEA, CAS | University of Oxford, NHS Health Technology Assessment Programme, BUPA Foundation, British Heart Foundation | Carotid Stenosis | 12/20 | 12/25 | | |
| Recruiting | N/A | 2000 | Europe, Canada, US | Gelsoft Plus Vascular Graft, Gelsoft Plus, Vascular Bypass Graft, Gelsoft Plus Extra Anatomical, Cardiovascular Patch, Gelseal Patch, Gelsoft Patch, Thinwall Patch, Cardiovascular Fabrics, Gelweave Vascular Graft, Gelweave, Gelweave Valsalva Vascular Graft, Gelweave Valsalva | Vascutek Ltd. | Aneurysm, Dissection, Aortic Root Aneurysm, Aortic Root Dissection, Carotid Artery Injuries, Aortic Arch, Bypass Extremity Graft, Occlusive Vascular Disease, Aortic Diseases | 01/26 | 01/33 | | |
| Haas, Sebastian A |
| Completed | N/A | 380 | Europe | Individualized Goal Directed Therapy, Control Group | Universitätsklinikum Hamburg-Eppendorf, University of Giessen, University of Rostock | Hemodynamic Instability, Cardiac Output, High, Peroperative Complication | 03/23 | 08/23 | | |
| Augustin, Matthias |
BRAVE-AA-PEDS, NCT05723198: A Study of Baricitinib (LY3009104) in Children From 6 Years to Less Than 18 Years of Age With Alopecia Areata |
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| Recruiting | 3 | 595 | Europe, Canada, Japan, US, RoW | Baricitinib, LY3009104, Placebo | Eli Lilly and Company | Areata Alopecia, Alopecia, Hypotrichosis, Hair Diseases, Skin Diseases, Pathological Conditions, Anatomical | 09/24 | 08/29 | | |
NCT06046729: A Study of Eltrekibart (LY3041658) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa |
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| Recruiting | 2 | 350 | Europe, Canada, US, RoW | Eltrekibart, LY3041658, Placebo | Eli Lilly and Company | Hidradenitis Suppurativa | 08/25 | 07/26 | | |
| Active, not recruiting | 2 | 152 | Europe | allo-APZ2-CVU, Skin-derived ABCB5-positive dermal mesenchymal stromal cells, Placebo | RHEACELL GmbH & Co. KG, FGK Clinical Research GmbH | Skin Ulcer Venous Stasis Chronic | 06/26 | 06/26 | | |
| Enrolling by invitation | N/A | 1304 | Europe | non-interventional, non-interventional survey study | Universitätsklinikum Hamburg-Eppendorf, Sandoz | Psoriasis | 09/20 | 12/20 | | |
DEVISE, NCT06324695: Development and EValuation of an Online Intervention to Reduce Self-Stigma in People with Visible Chronic Skin DisEases |
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| Active, not recruiting | N/A | 298 | Europe | HautKompass | Universitätsklinikum Hamburg-Eppendorf, German Federal Ministry of Education and Research | Psoriasis, Alopecia Areata, Hidradenitis Suppurativa, Vitiligo, Atopic Dermatitis | 12/24 | 05/25 | | |
| Recruiting | N/A | 167 | NA | CPtcube, CPTpatch | Coldplasmatech, German Federal Ministry of Education and Research | Chronic Ulcer of Lower Extremity | 12/25 | 12/25 | | |
| Recruiting | N/A | 3500 | Europe | | Universitätsklinikum Hamburg-Eppendorf, Berufsverband der Deutschen Dermatologen e.V. (www.bvdd.de), Deutsche Dermatologische Gesellschaft e.V. (https://derma.de), AbbVie, Biogen, Janssen-Cilag G.m.b.H, medac GmbH, Merck Sharp & Dohme LLC, Novartis Pharmaceuticals, Pfizer Pharmaceuticals Ltd., Merck Serono GmbH, Germany, PsoNet.eu (http://www.psonet.eu/), Celgene, Eli Lilly and Company, Amgen, Almirall Hermal GmbH, UCB Pharma, Bristol-Myers Squibb, Viatris Inc., LEO Pharma | Psoriasis, Psoriatic-arthritis | 12/32 | 12/32 | | |
| Heesen, Christoph |
| Recruiting | 2 | 200 | Europe | Imatinib Mesylate, Methylprednisolone | Tomas Olsson, The Swedish Research Council | Multiple Sclerosis | 12/22 | 07/23 | | |
| Active, not recruiting | 2 | 450 | Europe, Canada, US, RoW | IMU-838, Vidofludimus calcium, Placebo matching IMU-838, Placebo Arm | Immunic AG | Multiple Sclerosis | 01/25 | 01/25 | | |
| Recruiting | 1/2 | 135 | Europe | CLS12311 low, CLS12311 medium, CLS12311 high, uncoupled RBCs | Cellerys AG, Novartis, Scope International AG, Tetec AG, Jung Diagnostics GmbH | Relapsing-remitting Multiple Sclerosis (RRMS) | 08/26 | 03/27 | | |
| Active, not recruiting | N/A | 400 | Europe, US | Deprexis, DeprexisPlus | Charite University, Berlin, Germany, National Multiple Sclerosis Society, Universitätsklinikum Hamburg-Eppendorf, Cedars-Sinai Medical Center, University of Missouri, Kansas City, Penn State University, King's College London, University Medical Center Goettingen, NeuroCure Clinical Research Center, Charite, Berlin | Multiple Sclerosis | 01/21 | 12/21 | | |
| Completed | N/A | 120 | Europe | Understanding MRI in MS (website), Control website | Universitätsklinikum Hamburg-Eppendorf, Sanofi | Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Clinically Isolated Syndrome | 12/22 | 12/22 | | |
| Completed | N/A | 234 | Europe | EBBC programme, Control group programme | Universitätsklinikum Hamburg-Eppendorf, Charite University, Berlin, Germany, University of Cologne, University Medical Center Goettingen, Heinrich-Heine University, Duesseldorf, Gaia AG, BKK Dachverband e.V., Deutsche Multiple Sklerose Gesellschaft (DMSG) | Multiple Sclerosis | 04/23 | 04/23 | | |
| Not yet recruiting | N/A | 55 | NA | PExMS and DECIMS-Wiki, DECIMS-Wiki | Universitätsklinikum Hamburg-Eppendorf, Marianne-Strauss-Klinik, Berg, Germany, Gesundheitszentrum St. Johannes Hospital, Bonn, Germany, University Hospital Cologne, Cologne, Germany, Rechts der Isar Hospital, Munich, Germany, University Medical Center Schleswig-Holstein, Kiel, Germany | Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Patient Engagement, Self Efficacy | 12/25 | 12/25 | | |
| Thomalla, Goetz |
| Active, not recruiting | 4 | 948 | Europe, Canada, US, RoW | Edoxaban, Lixiana, Savaysa, Non-anticoagulant medical therapy | Population Health Research Institute | Intracranial Hemorrhages, Atrial Fibrillation | 04/26 | 10/26 | | |
| Wichmann, Dominic |
| Recruiting | 3 | 225 | Europe, Canada, Japan, US, RoW | Olorofim, Olorofim (F901318), AmBisome®, AmBisome® (liposomal amphotericin B) | F2G Biotech GmbH, Iqvia Pty Ltd, Shionogi | Invasive Aspergillosis | 09/25 | 11/26 | | |
| Schnitzler, Alfons |
NCT05357989 / 2022-001542-38: A Double-blind Study to Investigate Efficacy and Safety of Buntanetap Compared With Placebo in Participants With Early PD |
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| Completed | 3 | 523 | Europe, US | buntanetap/posiphen, Posiphen Tartrate, ANVS401, Placebo | Annovis Bio Inc., TFS Trial Form Support | Parkinson's Disease, Idiopathic | 12/23 | 12/23 | | |
| Completed | 3 | 507 | Europe, US, RoW | Tavapadon, PF-06649751, CVL-751, Placebo | Cerevel Therapeutics, LLC | Parkinson Disease | 01/24 | 02/24 | | |
| Completed | 3 | 522 | Europe, Canada, US, RoW | Tavapadon, PF-06649751, CVL-751, Placebo | Cerevel Therapeutics, LLC | Parkinson Disease | 06/24 | 06/24 | | |
| Active, not recruiting | 2/3 | 110 | Europe, US | AMX0035, Placebo | Amylyx Pharmaceuticals Inc. | Progressive Supranuclear Palsy, PSP, Neurodegenerative Diseases, Atypical Parkinsonism | 04/26 | 11/29 | | |
PROSPER, NCT06355531: A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP) |
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| Recruiting | 2 | 220 | Europe, US | FNP-223, Placebo | Ferrer Internacional S.A. | Progressive Supranuclear Palsy | 11/26 | 11/26 | | |
LUMA, NCT05348785 / 2021-004849-20: A Study to Learn About the Safety of BIIB122 Tablets and Whether They Can Slow the Worsening of Early-Stage Parkinson's Disease in Adults Between the Ages of 30 and 80 |
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| Recruiting | 2 | 640 | Europe, Canada, Japan, US, RoW | BIIB122, DNL151, BIIB122-Matching Placebo | Biogen, Denali Therapeutics Inc. | Parkinson Disease | 12/25 | 12/25 | | |
