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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
Lomivorotov, Vladimir V
ICARUS, NCT03772990: Calcium Administration in Cardiac Surgery	Recruiting	4	818	RoW	Calcium Chloride, 0.9% Sodium Chloride	Meshalkin Research Institute of Pathology of Circulation, Università Vita-Salute San Raffaele	Cardiac Surgery, Cardiopulmonary Bypass	02/22	03/22
DELICATE, NCT03729011: Delirium Reduction by Volatile Anesthesia in Cardiac Surgery	Completed	4	353	RoW	Volatile agent, Sevoflurane, Desflurane, Isoflurane, Propofol	Meshalkin Research Institute of Pathology of Circulation	Delirium	01/24	01/24
NCT05073094: Esmolol for Myocardial Protection in Hypertrophic Obstructive Cardiomyopathy	Recruiting	4	80	RoW	Esmolol, Placebo	Meshalkin Research Institute of Pathology of Circulation	Hypertrophic Obstructive Cardiomyopathy	06/23	07/23
NCT03913481: Acute Normovolemic Hemodilution in High Risk Cardiac Surgery Patients.	Recruiting	N/A	2000	Europe, RoW	Acute normovolemic hemodilution, Standard care	Università Vita-Salute San Raffaele	C.Surgical Procedure; Cardiac	02/25	03/25
Bogachev-Prokophiev, Alexander V
NCT03636295: Low INR to Minimize Bleeding With Mechanical Valves Trial	Recruiting	3	2625	Europe, Canada, RoW	Warfarin, Coumadin	Population Health Research Institute, Hamilton Health Sciences Corporation	Bleeding Post-mechanical Valve Replacement, Thromboembolism Post-mechanical Valve Replacement	03/25	12/26
PRIZMA-pilot, NCT04470102: Edge-to-edge Mitral Valve Repair in the Surgical Treatment for Hypertrophic Cardiomyopathy	Recruiting	N/A	40	RoW	mitral valve repair by edge-to-edge technique, Alfieri stitch, Septal myectomy, Septal myectomy (SM)	Meshalkin Research Institute of Pathology of Circulation	Hypertrophic Obstructive Cardiomyopathy	01/21	01/22
Romanov, Alexander
SyncAV, NCT04100148: Post-Market Trial	Active, not recruiting	N/A	1686	Europe, Canada, Japan, US, RoW	SyncAV programmed ON, Fixed AV delay	Abbott Medical Devices	Congestive Heart Failure	06/25	12/25
PADN+AF, NCT05856461: Pulmonary Artery Denervation in Patients With Atrial Fibrillation and Group 2 of Pulmonary Hypertension	Recruiting	N/A	116	RoW	Pulmonary vein isolation, Sham pulmonary artery denervation, Pulmonary artery denervation	Meshalkin Research Institute of Pathology of Circulation	Atrial Fibrillation, Pulmonary Hypertension	12/24	02/25
Krestyaninov, Oleg
NCT03450577: International Bifurcation Study	Recruiting	N/A	5000	RoW	PCI of bifurcation lesions	Meshalkin Research Institute of Pathology of Circulation	Coronary Bifurcation Lesion	12/21	12/26
STENT-FREE, NCT05222061: A Study of Drug Coated Balloon For Treating the Side Branch in Complex Bifurcation Lesions	Recruiting	N/A	80	RoW	Drug coated balloon for the side brunch, Conventional balloon for the side brunch	Meshalkin Research Institute of Pathology of Circulation	Coronary Artery Disease	02/23	02/23
PROGRESS CTO, NCT02061436: Prospective Global Registry for the Study of Chronic Total Occlusion Intervention	Recruiting	N/A	2000	Europe, Canada, US, RoW		Minneapolis Heart Institute Foundation	Coronary Artery Disease	01/24	01/24
Khelimskii, Dmitrii
NCT03450577: International Bifurcation Study	Recruiting	N/A	5000	RoW	PCI of bifurcation lesions	Meshalkin Research Institute of Pathology of Circulation	Coronary Bifurcation Lesion	12/21	12/26
STENT-FREE, NCT05222061: A Study of Drug Coated Balloon For Treating the Side Branch in Complex Bifurcation Lesions	Recruiting	N/A	80	RoW	Drug coated balloon for the side brunch, Conventional balloon for the side brunch	Meshalkin Research Institute of Pathology of Circulation	Coronary Artery Disease	02/23	02/23
Sirota, Dmitry
DEPOSITION, NCT03954314: - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery	Terminated	3	3242	Canada, RoW	Tranexamic Acid, Cyklokapron	Population Health Research Institute	Bleeding, Surgical Blood Loss, Seizures	11/23	11/23
SCHOLAR-2, NCT04680442: Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction	Recruiting	2	130	Canada, RoW	Trastuzumab, Herceptin, Herzuma, Ogivri, Trazimera, Kanjinti, Pertuzumab, Perjeta, Trastuzumab emtansine, Kadcyla,	Population Health Research Institute	Breast Cancer, Heart Failure	01/25	06/25
NCT03753048: Total Arterial Revascularization (TAR)	Recruiting	N/A	880	RoW	Y-Graft, In-Situ	Meshalkin Research Institute of Pathology of Circulation, Kemerovo Cardiology Center	Coronary Artery Disease, Coronary Artery Bypass Grafting	03/23	03/24
NCT05757947: Study of the No-touch Saphenous Vein Graft	Recruiting	N/A	106	RoW	Сoronary bypass surgery according to the I-graft method, Сoronary bypass surgery by the method of free conduit	Meshalkin Research Institute of Pathology of Circulation	Coronary Artery Disease, Coronary Artery Stenosis, Graft Failure, Cardiac Ischemia, Surgery	04/25	12/25
Efremov, Sergey
ICARUS, NCT03772990: Calcium Administration in Cardiac Surgery	Recruiting	4	818	RoW	Calcium Chloride, 0.9% Sodium Chloride	Meshalkin Research Institute of Pathology of Circulation, Università Vita-Salute San Raffaele	Cardiac Surgery, Cardiopulmonary Bypass	02/22	03/22
DELICATE, NCT03729011: Delirium Reduction by Volatile Anesthesia in Cardiac Surgery	Completed	4	353	RoW	Volatile agent, Sevoflurane, Desflurane, Isoflurane, Propofol	Meshalkin Research Institute of Pathology of Circulation	Delirium	01/24	01/24
DEPOSITION, NCT03954314: - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery	Terminated	3	3242	Canada, RoW	Tranexamic Acid, Cyklokapron	Population Health Research Institute	Bleeding, Surgical Blood Loss, Seizures	11/23	11/23
TRICS-IV, NCT04754022: Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery	Recruiting	N/A	1440	Canada, RoW	Restrictive Transfusion Strategy, Liberal transfusion strategy	Unity Health Toronto	Disorder, Heart, Postoperative, Cardiac Surgery	07/23	01/24
PRINCE, NCT02427867: Ischaemic PReconditioning In Non Cardiac surgEry	Recruiting	N/A	1100	Europe, RoW	Remote ischemic preconditioning, no ischemic preconditioning	Università Vita-Salute San Raffaele	Myocardial Ischemia, Surgery	01/25	02/25
NCT03913481: Acute Normovolemic Hemodilution in High Risk Cardiac Surgery Patients.	Recruiting	N/A	2000	Europe, RoW	Acute normovolemic hemodilution, Standard care	Università Vita-Salute San Raffaele	C.Surgical Procedure; Cardiac	02/25	03/25
Roos-Hesselink, Jolien
NCT03636295: Low INR to Minimize Bleeding With Mechanical Valves Trial	Recruiting	3	2625	Europe, Canada, RoW	Warfarin, Coumadin	Population Health Research Institute, Hamilton Health Sciences Corporation	Bleeding Post-mechanical Valve Replacement, Thromboembolism Post-mechanical Valve Replacement	03/25	12/26
Guo, Linrui
NCT03636295: Low INR to Minimize Bleeding With Mechanical Valves Trial	Recruiting	3	2625	Europe, Canada, RoW	Warfarin, Coumadin	Population Health Research Institute, Hamilton Health Sciences Corporation	Bleeding Post-mechanical Valve Replacement, Thromboembolism Post-mechanical Valve Replacement	03/25	12/26