University of Wisconsin-Madison
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 118 Trials 
405 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Bell, Edward F
NCT01353313: Hydrocortisone for BPD

Active, not recruiting
3
800
US
Hydrocortisone, Placebo
NICHD Neonatal Research Network, National Center for Research Resources (NCRR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Heart, Lung, and Blood Institute (NHLBI), National Center for Advancing Translational Sciences (NCATS)
Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature, Bronchopulmonary Dysplasia
09/20
01/25
MoCHA, NCT03340727: Moderately Preterm Infants With Caffeine at Home for Apnea () Trial

Terminated
3
827
US
Caffeine Citrate, Placebo
NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Apnea of Prematurity
01/23
03/23
NCT04214834: Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS)

Active, not recruiting
3
190
US
Morphine, Methadone
Advancing Clinical Trials in Neonatal Opioid Withdrawal (ACT NOW) Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Neonatal Opioid Withdrawal Syndrome
01/24
06/26
BiB, NCT04545866: The Budesonide in Babies () Trial

Active, not recruiting
3
1160
US
budesonide (Pulmicort nebulizing suspension)., Pulmicort nebulizing suspension., surfactant (poractant alfa;Curosurf), poractant alfa;Curosurf
NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Bronchopulmonary Dysplasia (BPD), Respiratory Distress Syndrome, Prematurity; Extreme, Neonatal
09/24
12/26
NCT03456336: Management of the PDA Trial

Active, not recruiting
3
836
US
Active Treatment, Expectant Management
NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infant, Premature, Patent Ductus Arteriosus, Infant, Newborn, Diseases, Patent Ductus Arteriosus After Premature Birth
04/25
05/27
NCT02951130: Milrinone in Congenital Diaphragmatic Hernia

Active, not recruiting
2
66
US
Milrinone, Milrinone Lactate Injection, Primacor, Placebo (5% Dextrose), D5W
NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Congenital Diaphragmatic Hernia, Persistent Pulmonary Hypertension of the Newborn, Hypoxemic Respiratory Failure, Pulmonary Hypoplasia
09/24
03/25
NCT03927833: Cycled Phototherapy

Recruiting
N/A
1700
US
Phototherapy lights
NICHD Neonatal Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Hyper Bilirubinemia, Premature Infant
07/25
07/25
NCT05685745: Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

Recruiting
N/A
5000
Europe, Canada, Japan, US
The University of Texas Health Science Center, Houston, Nationwide Children's Hospital, University of Iowa, University of Alabama at Birmingham, Jichi Medical University, Saitama Medical University
Infant, Extremely Premature, Obstetric Labor, Premature, Premature Birth, Intensive Care, Neonatal, Intensive Care Units, Neonatal
01/28
01/28
NCT00063063: Generic Database of Very Low Birth Weight Infants

Recruiting
N/A
80000
US
NICHD Neonatal Research Network, National Center for Research Resources (NCRR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
03/30
03/30
NCT00009633: Follow-up Visit of High Risk Infants

Recruiting
N/A
68000
US
NICHD Neonatal Research Network, National Center for Research Resources (NCRR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
03/30
03/30
Barrett, Bruce
NOSES, NCT06076304: Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Sinusitis

Active, not recruiting
4
3720
US
Amoxicillin/Clavulanate Potassium 875 MG-125 MG Oral Tablet, Augmentin, Placebo, Inactive, Control, Budesonide nasal spray, Rhinocort, C-reactive protein, CRP
Daniel Merenstein, Patient-Centered Outcomes Research Institute, Medstar Health Research Institute, Penn State College of Medicine, University of Washington, Virginia Commonwealth University, University of California, Los Angeles, University of Wisconsin, Madison
Sinus Infection, Acute Sinusitis
10/28
12/28
Liu, Glenn
ERADICATE, NCT04484818: Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The Study

Active, not recruiting
3
27
US
Darolutamide, Antiandrogen ODM-201, BAY 1841788, BAY-1841788, BAY1841788, ODM 201, ODM-201, Goserelin Acetate, ZDX, Zoladex, Leuprolide Acetate, A-43818, Abbott 43818, Abbott-43818, Carcinil, Depo-Eligard, Eligard, Enanton, Enantone, Enantone-Gyn, Ginecrin, LEUP, Leuplin, Leuprorelin Acetate, Lucrin, Lucrin Depot, Lupron, Lupron Depot, Lupron Depot-3 Month, Lupron Depot-4 Month, Lupron Depot-Ped, Lutrate, Procren, Procrin, Prostap, TAP-144, Trenantone, Uno-Enantone, Viadur, Placebo Administration, Quality-of-Life Assessment, Quality of Life Assessment, Triptorelin, 6-D-Tryptophan-LH-RH, 6-D-Tryptophanluteinizing Hormone-releasing Factor, AY-25650, CL-118,532, Detryptoreline
ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
Prostate Carcinoma
12/25
05/28
NCT06675357: Using FAPI PET/MRI to Evaluate Prostate Cancer

Recruiting
2
30
US
FAPI, Positron Emission Tomography (PET), Magnetic Resonance Imaging
University of Wisconsin, Madison
Prostate Cancer Metastatic Disease, Prostate Cancers
10/26
10/26
NCT05828082: Testing the Effect of M1774 on Hard-to-Treat Refractory SPOP-mutant Prostate Cancer

Recruiting
2
20
US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Tuvusertib, ATR Kinase Inhibitor M1774, M 1774, M-1774, M1774, Ultrasound Imaging, 2-Dimensional Grayscale Ultrasound Imaging, 2-Dimensional Ultrasound Imaging, 2D-US, Ultrasonography, Ultrasound, Ultrasound Test, Ultrasound, Medical, US
National Cancer Institute (NCI)
Castration-Resistant Prostate Carcinoma, Refractory Prostate Carcinoma
04/25
04/25
NCT03232164: PSMA-based 18F-DCFPyL PET/CT and PET/MRI Pilot Studies in Prostate Cancer

Completed
1
126
US
18F-DCFPyL PET
University of Wisconsin, Madison
Prostate Cancer, Prostate Neoplasm
11/24
11/24
NCI-2020-04699, NCT04489719: Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer

Recruiting
N/A
48
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Questionnaire Administration, Radium Ra 223 Dichloride, Alpharadin, BAY 88-8223, BAY88-8223, Radium 223 Dichloride, RADIUM RA-223 DICHLORIDE, Radium-223 Dichloride, Xofigo
University of Washington, Bayer
Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone, Metastatic Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8
08/25
08/28
NCT05647564: PET/CT Characterization of Treatment Resistance

Recruiting
N/A
20
US
F-fluorodeoxyglucose positron emission tomography (FDG PET), prostate-specific membrane antigen positron emission tomography (PSMA PET)
University of Wisconsin, Madison
Prostate Cancer
03/25
03/27
Peng, Yu-Sen
NCT04543812: PBF-1681 (Ferric Citrate) for the Treatment of IDA in Patients With NDD-CKD

Completed
3
141
RoW
Ferric citrate, Placebo
Panion & BF Biotech Inc.
Anemia of Chronic Kidney Disease
10/22
12/22
ALIGN, NCT04573478: Atrasentan in Patients With IgA Nephropathy

Active, not recruiting
3
404
Europe, Canada, Japan, US, RoW
Atrasentan, CHK-01, Atrasentan Hydrochloride, ABT-627, Placebo
Chinook Therapeutics, Inc.
IgA Nephropathy, Immunoglobulin A Nephropathy
12/26
12/26
REGEN-006, NCT05099770: A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease

Recruiting
3
685
Europe, Canada, US, RoW
Renal Autologous Cell Therapy (REACT), Sham Comparator
Prokidney, Iqvia Pty Ltd, PPD
Type 2 Diabetes Mellitus, Chronic Kidney Diseases
02/27
02/27
SURMOUNT-MMO, NCT05556512: A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

Active, not recruiting
3
15374
Europe, Canada, Japan, US, RoW
Tirzepatide, LY3298176, Placebo
Eli Lilly and Company
Obesity, Overweight
10/27
10/27
PALIZADE, NCT05781750: A Study of Zetomipzomib (KZR-616) in Patients With Active Lupus Nephritis

Suspended
2
279
Europe, US, RoW
zetomipzomib, KZR-616, placebo, matching placebo
Kezar Life Sciences, Inc.
Lupus Nephritis
05/26
07/26
Thibeault, Susan
NCT04658342: Effects of Oral Cancer Treatments on Upper Esophageal Opening During Swallowing

Terminated
N/A
5
US
Videofluoroscopic imaging (VFSS) with high-resolution manometry (HRM)
University of Wisconsin, Madison
Cancer of Head and Neck
03/23
03/23
NCT06152627: Voice Therapy Per the Rehabilitation Treatment Specification System

Not yet recruiting
N/A
600
US
Standard of care voice therapy with novice clinician RTSS-Voice documentation, Standard of care voice therapy with expert clinician RTSS-Voice documentation
Massachusetts General Hospital, Emory University, New York University, University of Utah, University of Wisconsin, Madison
Muscle Tension Dysphonia
08/27
08/27
Dempsey, Robert J
I-ACQUIRE, NCT03910075: Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation

Active, not recruiting
3
216
US
I-ACQUIRE - High Dosage, ACQUIRE, Pediatric Constraint-Induced Movement Therapy, P-CIMT, I-ACQUIRE - Moderate Dosage, Usual & Customary Treatment (U&CT)
Virginia Polytechnic Institute and State University, Ohio State University, Nationwide Children's Hospital, Stanford University, University of Cincinnati, Medical University of South Carolina
Perinatal Stroke, Hemiparesis
10/25
05/26
NCT04382963: Stroke Prevention in the Wisconsin Native American Population

Active, not recruiting
N/A
120
US
High Risk - intensive coaching, High Risk - standard care, Low Risk - control
University of Wisconsin, Madison, Wisconsin Partnership Program
Stroke, Atherosclerosis
06/25
06/25
NCT02476396: Structural Stability of Carotid Plaque and Symptomatology

Completed
N/A
176
US
Carotid Endarterectomy or Stenting
University of Wisconsin, Madison, National Heart, Lung, and Blood Institute (NHLBI), National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis, Stroke, Carotid Artery Plaque, Transient Ischemic Attack, Cerebrovascular Accident, Carotid Artery Stenosis
07/24
07/24
Sleep SMART, NCT03812653: Sleep for Stroke Management and Recovery Trial

Recruiting
N/A
3062
US
CPAP
University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), FusionHealth LLC, Medical University of South Carolina, University of Cincinnati
Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial
11/26
11/26
Taxman, Faye S
NCT04363320: Fostering MAT Use in Justice Populations

Completed
N/A
264
US
NIATx Coaching, ECHO, Extension for Community Healthcare Outcomes
University of Wisconsin, Madison, George Mason University, National Institute on Drug Abuse (NIDA)
Opioid-use Disorder, Recidivism
02/24
02/24
Voils, Corrine I
NCT05132478: The Effect of Surgeon Emotional Support on Treatment Choice for Low-risk Thyroid Cancer

Completed
N/A
126
US
Emotionally Supportive Video, Standard Video
University of Wisconsin, Madison, National Cancer Institute (NCI), University of Michigan
Thyroid Cancer, Thyroid Nodule, Benign Thyroid Nodule
02/23
02/23
NCT03801174: Using Partners to Enhance Long-Term Weight Loss

Completed
N/A
346
US
Partner-assisted intervention, Patient-only intervention
University of Wisconsin, Madison, Duke University, RTI International, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
03/23
03/23
NCT05646771: Feasibility Study for Collaborate2Lose

Completed
N/A
20
US
Partner support
University of Wisconsin, Madison, William S. Middleton Memorial Veterans Hospital
Obesity
08/23
08/23
Log2Lose, NCT04770909: Incenting Weight Loss and Dietary Self-monitoring in Real-time to Improve Weight Management Among Adults With Obesity

Active, not recruiting
N/A
700
US
Incentives for dietary self-monitoring and weight loss, Incentives for dietary self-monitoring, Incentives for weight loss
University of Wisconsin, Madison, Duke University, National Heart, Lung, and Blood Institute (NHLBI)
Obesity
04/24
04/25
NCT05448313: Collaborate2Lose: Involving Support Persons in Weight Management

Active, not recruiting
N/A
300
US
Dyadic intervention, Veteran-only intervention
VA Office of Research and Development
Obesity
08/25
08/25
Drolet, Beth A
EPIK-P2, NCT04589650 / 2020-000561-16: Study Assessing the Efficacy, Safety and PK of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum

Recruiting
2
205
Europe, Canada, US, RoW
Alpelisib, Placebo
Novartis Pharmaceuticals
PIK3CA-related Overgrowth Spectrum (PROS)
03/24
04/31
NCT04772911: Multicenter Phenotype-Genotype Analysis of Vascular Stains to Optimize Treatment Utilizing Optical Coherence Tomography

Active, not recruiting
N/A
73
US
Optical Coherence Tomography (OCT)
University of Wisconsin, Madison
Vascular Stains
04/25
04/27
Jarjour, Nizar N
NCT04129931: PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study

Active, not recruiting
2
395
US
MCT, Breathe Better Diet (BBD), Clazakizumab, Anti-interleukin 6 monoclonal antibody, Anti-IL-6 mAb, BMS-945429, ALD518, Broncho-Vaxom, OM-85 BV VEGETAL, Imatinib Mesylate, Gleevec, Zoleta, Glivec, Ziatir, Cavosonstat, N91115, Placebo
University of North Carolina, Chapel Hill, National Heart, Lung, and Blood Institute (NHLBI)
Asthma
12/24
12/24
NCT01760915: University of Wisconsin Severe Asthma Research Program III

Completed
N/A
107
US
NC100182 Hyperpolarized 3He, helium
University of Wisconsin, Madison, National Institutes of Health (NIH), Washington University School of Medicine, National Heart, Lung, and Blood Institute (NHLBI)
Asthma
03/20
12/21
NCT01606826: Severe Asthma Research Program

Active, not recruiting
N/A
1100
US
Milton S. Hershey Medical Center, National Heart, Lung, and Blood Institute (NHLBI)
Asthma
06/26
12/26
Yu, Evan Y
KEYNOTE-D74, NCT05911295: Disitamab Vedotin With Pembrolizumab vs Chemotherapy in Previously Untreated Urothelial Cancer Expressing HER2

Recruiting
3
700
Europe, Canada, US, RoW
disitamab vedotin, RC48, RC48-ADC, pembrolizumab, KEYTRUDA®, gemcitabine, Gemzar, cisplatin, carboplatin
Seagen Inc., RemeGen Co., Ltd., Merck Sharp & Dohme LLC
Urothelial Carcinoma
06/26
04/29
NCT03513952: Atezolizumab and CYT107 in Treating Participants With Locally Advanced, Inoperable, or Metastatic Urothelial Carcinoma

Completed
2
47
US
Atezolizumab, MPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG 7446, RG-7446, RG7446, RO 5541267, RO-5541267, RO5541267, Tecentriq, Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Glycosylated Recombinant Human Interleukin-7, CYT-107, CYT107, Glycosylated rhIL-7, INTERLEUKIN-7 HUMAN RECOMBINANT, Laboratory Biomarker Analysis, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Positron Emission Tomography and Computed Tomography Scan, PET-CT Scan, PET/CT SCAN, Positron Emission Tomography/Computed Tomography
National Cancer Institute (NCI)
Advanced Bladder Urothelial Carcinoma, Advanced Ureter Urothelial Carcinoma, Metastatic Bladder Urothelial Carcinoma, Metastatic Renal Pelvis Urothelial Carcinoma, Metastatic Ureter Urothelial Carcinoma, Metastatic Urethral Urothelial Carcinoma, Metastatic Urothelial Carcinoma, Recurrent Bladder Urothelial Carcinoma, Recurrent Renal Pelvis Urothelial Carcinoma, Recurrent Ureter Urothelial Carcinoma, Recurrent Urethral Urothelial Carcinoma, Stage III Bladder Cancer AJCC v8, Stage III Renal Pelvis Cancer AJCC v8, Stage III Ureter Cancer AJCC v8, Stage III Urethral Cancer AJCC v8, Stage IV Bladder Cancer AJCC v8, Stage IV Renal Pelvis Cancer AJCC v8, Stage IV Ureter Cancer AJCC v8, Stage IV Urethral Cancer AJCC v8, Stage IVA Bladder Cancer AJCC v8, Stage IVB Bladder Cancer AJCC v8, Unresectable Bladder Urothelial Carcinoma, Unresectable Renal Pelvis Urothelial Carcinoma, Unresectable Ureter Urothelial Carcinoma
09/23
04/24
SGNTUC-019, NCT04579380 / 2020-004873-29: Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations

Active, not recruiting
2
217
Europe, Japan, US, RoW
tucatinib, TUKYSA, ARRY-380, ONT-380, trastuzumab, Herceptin, fulvestrant, Faslodex
Seagen Inc., Seagen, Inc.
Uterine Neoplasms, Uterine Cervical Neoplasms, Biliary Tract Neoplasms, Urologic Neoplasms, Carcinoma, Non-Small-Cell Lung, HER2 Mutations Breast Neoplasms
11/23
05/25
Flu-BLAST-PC, NCT04175431: Prostate Specific Membrane Antigen (PSMA) or (FACBC) PET/CT Site-Directed Therapy for Treatment of Prostate Cancer, Study

Recruiting
2
100
US
Positron Emission Tomography, Medical Imaging, PET Scan, positron emission tomography scan, proton magnetic resonance spectroscopic imaging, Positron-Emission Tomography, Lymphadenectomy, Lymph Node Dissection, lymph node excision, excision of the lymph node, Radiation Therapy, Cancer Radiotherapy, Irradiation, Radiotherapeutics, RT, ENERGY_TYPE, Irradiated, Therapy, Radiation, NOS, Abiraterone Acetate, 154229-18-2, Yonsa, Zytiga, Androsta-5, Prednisone, Deltasone, Prednicort, Prednisone Intensol, Rayos, Sterapred, Dehydrocortisone, Prednilonga, Servisone, Computed Tomography, CAT Scan, CAT, computerized axial tomography, computerized tomography, CT Scan, Abiraterone, 154229-19-3, 17-(3-Pyridyl)androsta-5, 16-dien-3beta-ol, CB 7598, PSMA PET Scan, Prostate-specific Membrane Antigen PET, PSMA PET, PSMA-Positron emission tomography
University of Washington, Blue Earth Diagnostics
Prostate Adenocarcinoma
07/26
07/31
KEYNOTE-D78, NCT04879329: A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

Recruiting
2
332
Europe, Canada, Japan, US, RoW
disitamab vedotin, RC48-ADC, pembrolizumab, KEYTRUDA®
Seagen Inc., Merck Sharp & Dohme LLC
Urothelial Carcinoma
11/26
05/28
NCI-2020-04699, NCT04489719: Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer

Recruiting
N/A
48
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Questionnaire Administration, Radium Ra 223 Dichloride, Alpharadin, BAY 88-8223, BAY88-8223, Radium 223 Dichloride, RADIUM RA-223 DICHLORIDE, Radium-223 Dichloride, Xofigo
University of Washington, Bayer
Castration-Resistant Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone, Metastatic Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8
08/25
08/28
Carlsson, Cynthia M
PREVENTABLE, NCT04262206: Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

Recruiting
4
20000
US
Atorvastatin 40 Mg Oral Tablet, Lipitor, Placebo oral tablet
Duke University, National Institute on Aging (NIA), National Heart, Lung, and Blood Institute (NHLBI), Wake Forest University Health Sciences
Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases
12/26
12/26
BRAVE-EPA, NCT02719327: Brain Amyloid and Vascular Effects of Eicosapentaenoic Acid

Completed
2/3
131
US
icosapent ethyl (IPE), Vascepa, gel cap placebo, Placebo
VA Office of Research and Development, University of Wisconsin, Madison
Alzheimer's Disease
09/23
09/23
START, NCT05531656: A Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease

Recruiting
2
540
US
CT1812, Study Drug Active, Placebo, Matching Placebo
Cognition Therapeutics, National Institute on Aging (NIA), Alzheimer's Clinical Trials Consortium
Early Alzheimer's Disease
04/27
04/27
TRC-PAD, NCT04004767: Program: In-Clinic Trial-Ready Cohort

Completed
N/A
220
US
University of Southern California, National Institute on Aging (NIA), Alzheimer's Therapeutic Research Institute, Alzheimer's Clinical Trials Consortium, Brigham and Women's Hospital, Cleveland Clinic Lou Ruvo Center for Brain Health
Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease, Alzheimer Disease, Dementia
04/24
04/24
Guilbert, Theresa W
SWIFT-2, NCT04718103 / 2020-003611-10: A Study of GSK3511294 (Depemokimab) in Participants With Severe Asthma With an Eosinophilic Phenotype

Hourglass Jul 2024 - Dec 2024 : H2'24 - Acceptance of regulatory submission in US (based on SWIFT-1 trial) for asthma
Completed
3
397
Europe, Canada, Japan, US, RoW
GSK3511294, Depemokimab, Placebo
GlaxoSmithKline, Iqvia Pty Ltd
Asthma
04/24
04/24
NCT05757102: A Study to Compare the Efficacy, Safety and Tolerability of FF/UMEC/VI With FF/VI in 12-17-year-olds With Asthma

Recruiting
3
292
US, RoW
FF/UMEC/VI, ELLIPTA, FF/VI
GlaxoSmithKline
Asthma
01/27
01/27
NCT05243680 / 2020-004334-38: An Open-Label Extension Study of GSK3511294 (Depemokimab) in Participants Who Were Previously Enrolled in 206713 (NCT04719832) or 213744 (NCT04718103)

Active, not recruiting
3
641
Europe, Canada, Japan, US, RoW
GSK3511294 (Depemokimab)
GlaxoSmithKline, Iqvia Pty Ltd
Asthma
05/25
05/25
NIMBLE, NCT04718389 / 2020-003612-28: A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype

Hourglass Feb 2024 - Jun 2024 : Acceptance of regulatory submission in China for CRSwNP
Active, not recruiting
3
1667
Europe, Canada, Japan, US, RoW
GSK3511294 (Depemokimab), Mepolizumab, Benralizumab, Placebo, Standard of care (SoC), Pre-filled Syringes (PFS)
GlaxoSmithKline, Iqvia Pty Ltd
Asthma
10/25
10/25
PARK, NCT02570984: Preventing Asthma in High Risk Kids

Active, not recruiting
2
200
US
Omalizumab, Xolair, Placebo, placebo arm
Boston Children's Hospital, National Institute of Allergy and Infectious Diseases (NIAID)
Asthma
01/28
03/28
Shannon, Kathleen M
TOPAZ, NCT03924414: Trial of Parkinson's And Zoledronic Acid

Recruiting
4
2650
US
Zoledronic Acid 5Mg/Bag 100Ml Inj, Reclast, Placebo
California Pacific Medical Center Research Institute, National Institute on Aging (NIA), University of California, San Francisco, Duke University, University of Pittsburgh, Parkinson's Foundation
Parkinson Disease, Osteoporosis, Parkinsonism, Parkinson's Disease and Parkinsonism, Atypical Parkinsonism, Progressive Supranuclear Palsy, Multiple System Atrophy, Vascular Parkinsonism, Dementia With Lewy Bodies
10/25
10/25
NCT03655236: PROSEEK: A Phase 2 Study In Early Parkinson's Disease Patients Evaluating The Safety And Efficacy Of Abl Tyrosine Kinase Inhibition Using K0706

Terminated
2
513
Europe, US, RoW
K0706, placebo
Sun Pharma Advanced Research Company Limited
Early Parkinson Disease
04/24
06/24
NCT05923866: A Phase 2 Study of ONO-2808 in Patients With Multiple System Atrophy

Recruiting
2
80
US
ONO-2808, Placebo
Ono Pharmaceutical Co. Ltd
Multiple System Atrophy (MSA)
08/25
08/25
NCT01574053: Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

Recruiting
N/A
35000
Europe, Canada, US, RoW
CHDI Foundation, Inc.
Huntington's Disease
01/62
01/62
Armstrong, Andrew J
SYNERGY-201, NCT06228053: Study of SX-682 Plus Enzalutamide in Men with Abiraterone-Resistant Metastatic Castration Resistant Prostate Cancer

Recruiting
2
53
US
SX-682, Enzalutamide, Xtandi
Syntrix Biosystems, Inc., National Cancer Institute (NCI)
Metastatic Castration-resistant Prostate Cancer
06/26
06/28
CHAMP, NCT04709276: A Study of Chemoimmunotherapy for the Treatment of Men With Neuroendocrine or Aggressive Variant Metastatic Prostate Cancer

Recruiting
2
43
US
Nivolumab, BMS-936558, MDX1106, ONO-4538, Ipilimumab, BMS-734016, MDX010, MDX-CTLA4, Carboplatin, Cabazitaxel, JEVTANA
Andrew J. Armstrong, MD, Bristol-Myers Squibb
Metastatic Prostate Neuroendocrine Carcinoma, Metastatic Prostate Cancer
12/25
06/28
COMBAT, NCT05633160: 64Cu-SAR-BBN and 67CU SAR-BBN for Identification and Treatment of Gastrin Releasing Peptide Receptor (GRPR)-Expressing Metastatic Castrate Resistant Prostate Cancer in Patients Who Are Ineligible for Therapy With 177Lu-PSMA-617

Recruiting
1/2
38
US
64Cu-SAR-BBN, 67Cu-SAR-BBN
Clarity Pharmaceuticals Ltd
Prostatic Neoplasms, Castration-Resistant
05/26
05/26
PRESERVE-006, NCT05682443: ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With mCRPC

Recruiting
1/2
144
US
ONC-392, A humanized anti-CTLA4 IgG1 monoclonal antibody, Gotistobart, lutetium Lu 177 vipivotide tetraxetan, IV infusion, Q6W for up to 6 doses., Pluvicto
OncoC4, Inc., Prostate Cancer Clinical Trials Consortium
Metastatic Castration-resistant Prostate Cancer
06/26
06/27
ARCTIC, NCT06141993: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials

Recruiting
N/A
120
US
Duke University, University of Wisconsin, Madison, Memorial Sloan Kettering Cancer Center
Prostate Cancer, Prostate Adenocarcinoma, Prostate Cancer Metastatic, Castration-resistant Prostate Cancer
04/27
04/27
Whigham, Leah D
NCT06668272: Small Changes Clinical Weight Loss Trial

Not yet recruiting
N/A
52
US
Small Changes program, Standard behavioral therapy for weight loss
The University of Texas Health Science Center, Houston
Obesity
11/25
11/25
Davidson, Richard J
STRENGTHEN, NCT06267521: The Study

Recruiting
N/A
48
US
Healthy Minds Program, Health Minds App, Sham Meditation Didactic Material, Sham Stimulation in Lab, Stimulation in Lab, TES-TI, Transcranial Electrical Stimulation with Temporal Interference, MRI Scanner, 3 Tesla MAGNUS, Microstructure Anatomy Gradient for Neuroimaging with Ultrafast Scanning
University of Wisconsin, Madison, United States Department of Defense
Cognitive Flexibility, Emotional Regulation
02/25
02/25
NCT05826860: Storytelling and Mindfulness for Graduate Student Wellbeing

Recruiting
N/A
250
US
Mindfulness Practice, Storytelling Workshop
University of Wisconsin, Madison
Depression, Anxiety, Burnout, Student
05/27
05/27
Steele, Andrew W
ALIGN, NCT04573478: Atrasentan in Patients With IgA Nephropathy

Active, not recruiting
3
404
Europe, Canada, Japan, US, RoW
Atrasentan, CHK-01, Atrasentan Hydrochloride, ABT-627, Placebo
Chinook Therapeutics, Inc.
IgA Nephropathy, Immunoglobulin A Nephropathy
12/26
12/26
NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

Recruiting
3
10000
Europe, Canada, US, RoW
Retatrutide, LY3437943, Placebo
Eli Lilly and Company
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
02/29
02/29
REGEN-006, NCT05099770: A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease

Recruiting
3
685
Europe, Canada, US, RoW
Renal Autologous Cell Therapy (REACT), Sham Comparator
Prokidney, Iqvia Pty Ltd, PPD
Type 2 Diabetes Mellitus, Chronic Kidney Diseases
02/27
02/27
PHOSPHATE, NCT03573089: Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease

Recruiting
N/A
3600
Europe, Canada, RoW
Liberal phosphate target, Intensive phosphate target
The University of Queensland, National Health and Medical Research Council, Australia, Applied Health Research Centre, Cambridge University Hospitals NHS Foundation Trust, University of Otago
Kidney Failure, Chronic, Hyperphosphatemia
12/27
12/28
Saha, Sumona
NCT02461784: The Effect of Methotrexate on Sperm Quality in Men With Inflammatory Bowel Disease

Terminated
N/A
30
US
Semen & Data Collection
University of Wisconsin, Madison
Inflammatory Bowel Disease (IBD)
03/20
03/20
Hematti, Peiman
NCT01656603: Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation

Recruiting
2
9999
US
unlicensed CBU
New York Blood Center
Infusion Reactions
12/25
12/25
Plante, David T
NCT05156047: A Phase 3 Study to Assess the Safety and Efficacy of Pitolisant in Adult Patients With Idiopathic Hypersomnia

Completed
3
214
US
Open-label pitolisant, Double-blind placebo, Double-blind pitolisant
Harmony Biosciences, LLC
Idiopathic Hypersomnia
09/23
09/23
Strasburger, Janette
NCT02624765: Prospective Randomized Clinical Trial of Fetal Atrial Flutter & Supraventricular Tachycardia Therapy (FAST RCT)

Completed
3
105
Europe, Canada, US, RoW
Digoxin (monotherapy), Sotalol (monotherapy), Flecainide (monotherapy), Digoxin (dual therapy), Sotalol (dual therapy), Flecainide (dual therapy)
Edgar Jaeggi, Canadian Institutes of Health Research (CIHR)
Fetal Atrial Flutter Without Hydrops, Fetal Supraventricular Tachycardia Without Hydrops, Fetal Supraventricular Tachycardia With Hydrops
03/24
03/24
NCT03775954: Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise

Recruiting
N/A
200
US
Fetal Magnetocardiogram and Neonatal Electrocardiogram
Medical College of Wisconsin, National Heart, Lung, and Blood Institute (NHLBI), University of Wisconsin, Madison, Children's Hospital and Health System Foundation, Wisconsin, Shared Medical Technology, Inc., Tristan Technologies, Inc
High Risk Pregnancy, Congenital Heart Disease, Fetal Hydrops, Twin Monochorionic Monoamniotic Placenta, Gastroschisis, Fetal Demise, Stillbirth, Fetal Arrhythmia, Long QT Syndrome, Intrauterine Fetal Death, Sudden Infant Death, Pregnancy Loss, Twin Twin Transfusion Syndrome, Birth Defect, Fetal Cardiac Anomaly, Fetal Cardiac Disorder, Fetal Death, Brugada Syndrome
04/24
04/24
FAST Registry, NCT03376438: Prospective Observational Cohort Study of Fetal Atrial Flutter & Supraventricular Tachycardia

Recruiting
N/A
400
Europe, Canada, US, RoW
Prospective observational cohorts, Non-randomized antiarrhythmic fetal drug therapy
Edgar Jaeggi, Labatt Family Heart Centre
Atrial Flutter, Tachycardia, Supraventricular, Tachycardia, Atrial Ectopic, Tachycardia, Reciprocating, Tachycardia Atrial, Tachycardia, Atrioventricular Nodal Reentry, Tachycardia, Paroxysmal, Fetal Hydrops
12/24
05/25
Greenberg, Caprice C
NCT04173884: Video-based Collaborative Learning to Improve Ventral Hernia Repair

Recruiting
N/A
54
US
Coaching, Constructive Feedback
Augusta University, Agency for Healthcare Research and Quality (AHRQ), University of Wisconsin, Madison, Abdominal Core Health Quality Collaborative
Ventral Hernia
01/22
09/24
Smith, Jason
Levo, NCT06428097: thyroxine Supplementation for Heart Transplant Recipients

Recruiting
1
97
US
Levothyroxine, Normal saline
University of California, San Francisco
Heart Transplant Failure, Heart Transplant Infection
03/27
03/27
ELHS, NCT06265103: Epilepsy Learning Healthcare System

Recruiting
N/A
100000
US
Clinical care and quality improvement
Epilepsy Foundation of America
Epilepsy, Seizure Disorder, Neurologic Disorder, Rare Diseases
02/99
02/99
NCT01191151: Web Based Orthopaedic Sports Medicine Registry

Terminated
N/A
12500
Europe, Canada, US, RoW
Arthrex, Inc.
Degenerative and Traumatic Pathology of the Knee, Degenerative and Traumatic Pathology of the Shoulder and Elbow, Degenerative and Traumatic Pathology of the Foot and Ankle, Degenerative and Traumatic Pathology of the Hand and Wrist, Degenerative and Traumatic Pathology of the Hip
07/23
07/23
PEERLESS, NCT05111613: The Study

Completed
N/A
692
Europe, US
Catheter-Directed Thrombolysis, FlowTriever System
Inari Medical
Pulmonary Embolism, Pulmonary Thrombo-embolism
03/24
04/24
Kaufman, Dixon
NCT03292445: Inducing Graft Tolerance in HLA Haplotype Matched Related and 3 Ag Matched Unrelated Living Donor Kidney Transplantation

Recruiting
1
24
US
Immune tolerance after kidney transplant, Donor blood stem cells and T cells
Samuel Strober, California Institute for Regenerative Medicine (CIRM)
Immune Tolerance
02/22
02/24
Molfenter, Todd D
NCT03954184: E-health Implementation (Iowa)

Completed
N/A
39
US
NIATx-TI with Product Training/On-line Support
University of Wisconsin, Madison, University of Iowa, Iowa Department of Public Health, National Institute on Drug Abuse (NIDA)
Substance Use Disorders
06/23
06/23
NCT04363320: Fostering MAT Use in Justice Populations

Completed
N/A
264
US
NIATx Coaching, ECHO, Extension for Community Healthcare Outcomes
University of Wisconsin, Madison, George Mason University, National Institute on Drug Abuse (NIDA)
Opioid-use Disorder, Recidivism
02/24
02/24
NCT06581250: Improving Show Rates in Dental Care Settings Serving Underserved Populations

Not yet recruiting
N/A
40
NA
Reminder Messages, Walk-in Visits, Motivation-enhanced Communication
University of Wisconsin, Madison, National Institute of Dental and Craniofacial Research (NIDCR)
Dental Care
01/29
01/29
Barnes, Jill N
NCT06629090: Brain Blood Vessel Responses to Changes in Blood Flow

Not yet recruiting
2
36
US
MRI, Prazosin, Placebo
University of Wisconsin, Madison
Magnetic Resonance Imaging, Cerebrovascular Circulation
08/26
08/26
NCT06629077: Brain Blood Vessel Responses to Changes in Blood Flow

Not yet recruiting
2
36
US
MRI, Prazosin, Placebo
University of Wisconsin, Madison, National Institute of Neurological Disorders and Stroke (NINDS)
Magnetic Resonance Imaging, Cerebrovascular Circulation
08/26
08/26
NCT04133701: Meal Timing and Blood Pressure

Completed
N/A
34
US
Time-Restricted Feeding
University of Wisconsin, Madison, American Heart Association
Blood Pressure, Neurovascular Control
12/22
12/22
NCT06446622: Brain Blood Flow Responses During Exercise: Younger Cohort

Recruiting
N/A
45
US
MRI
University of Wisconsin, Madison
Cerebrovascular Circulation, Magnetic Resonance Imaging
06/25
06/25
NCT05396287: Blood Vessel Anatomy and Blood Flow Regulation

Enrolling by invitation
N/A
80
US
MRI
University of Wisconsin, Madison, National Institute of Neurological Disorders and Stroke (NINDS)
Brain Blood Flow, Healthy
01/25
01/25
NCT05864950: Brain Blood Flow Responses During Exercise

Recruiting
N/A
80
US
MRI
University of Wisconsin, Madison, National Institute of Neurological Disorders and Stroke (NINDS)
Cerebrovascular Circulation, Magnetic Resonance Imaging
06/25
06/25
NCT04586049: Cardiovascular and Neurovascular Regulation in GWI

Recruiting
N/A
70
US
MRI, Transcranial Doppler Ultrasound, Sympathetic Nerve Activity
University of Wisconsin, Madison, United States Department of Defense
Brain Blood Flow, Neurovascular Control
03/25
03/25
Crnich, Christopher J
VA INTREPID, NCT03012529: Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics

Recruiting
4
880
US
Rifampin, Riboflavin Placebo
VA Office of Research and Development
Osteomyelitis, Diabetes, Amputation
09/25
09/25
Agarwal, Suresh
NCT05354141: Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)

Recruiting
3
970
US
ExoFlo, Intravenous normal saline
Direct Biologics, LLC
Acute Respiratory Distress Syndrome, ARDS
03/25
08/25
Anagnostopoulos, Petros V
NCT05253209: A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects

Terminated
3
64
US
L-citrulline, Plasmalyte A
Asklepion Pharmaceuticals, LLC
Ventricular Septal Defect, Atrioventricular Septal Defect, Primum Atrial Septal Defect
05/24
05/24
Wu, Mai-Szu
NCT04543812: PBF-1681 (Ferric Citrate) for the Treatment of IDA in Patients With NDD-CKD

Completed
3
141
RoW
Ferric citrate, Placebo
Panion & BF Biotech Inc.
Anemia of Chronic Kidney Disease
10/22
12/22
ALIGN, NCT04573478: Atrasentan in Patients With IgA Nephropathy

Active, not recruiting
3
404
Europe, Canada, Japan, US, RoW
Atrasentan, CHK-01, Atrasentan Hydrochloride, ABT-627, Placebo
Chinook Therapeutics, Inc.
IgA Nephropathy, Immunoglobulin A Nephropathy
12/26
12/26
REGEN-006, NCT05099770: A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease

Recruiting
3
685
Europe, Canada, US, RoW
Renal Autologous Cell Therapy (REACT), Sham Comparator
Prokidney, Iqvia Pty Ltd, PPD
Type 2 Diabetes Mellitus, Chronic Kidney Diseases
02/27
02/27
SURMOUNT-MMO, NCT05556512: A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

Active, not recruiting
3
15374
Europe, Canada, Japan, US, RoW
Tirzepatide, LY3298176, Placebo
Eli Lilly and Company
Obesity, Overweight
10/27
10/27
NCT02933827: Adipose-derived Stem Cells (ADSCs) for Moderate to Severe Chronic Kidney Disease

Completed
1/2
39
RoW
ELIXCYTE
UnicoCell Biomed CO. LTD, Protech Pharmaservices Corporation (PPC)
Moderate to Severe Chronic Kidney Disease
04/19
06/23
 

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