| LOCKEY, RICHARD F |
NCT02630121: Effect of Oxymetazoline Hydrochloride in Combination With Fluticasone Propionate on the Apnea Hypopnea Index (AHI) in Subject With Persistent Nasal Congestion and Mild Obstructive Sleep Apnea |
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| Recruiting | 4 | 52 | US | Oxymetazoline Hydrochloride, Afrin, Placebo, Nasal saline | University of South Florida | Sleep Apnea, Chronic Nasal Congestion | 04/24 | 04/24 | | |
NCT04430179: Dupilumab Severe Eosinophilic Chronic Sinusitis Without Nasal Polyposis |
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| Recruiting | 2 | 30 | US | Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT], Placebo | University of South Florida | Severe Eosinophilic Chronic Sinusitis Without Nasal Polyposis | 07/23 | 12/23 | | |
| MD |
NCT06195228: A Retrospective and Prospective Real-world Study of Molecular Typing in the Treatment of Advanced Thyroid Cancer |
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| Recruiting | 4 | 200 | RoW | dabrafenib plus trametinib with or without PD-1 antibody, entrectinib or larotrectinib with or without anti-PD-1 antibdoy, pralsetinib or selpercatinib with or without anti-PD-1 antibdoy, anlotinib or anlotinib plus anti-PD-1 antibody, lenvatinib plus anti-PD-1 antibody, Other Targets: precise treatment based on the target | Fudan University, Inner Mongolia Cancer Hospital Affiliated To Inner Mongolia Medical University, Shanxi Province Cancer Hospital | Advanced Thyroid Cancer Patients Who Received Target Therapy | 04/26 | 04/27 | | |
COMeBAC, NCT06726395: Comparison of Cloxacillin and Benzylpenicillin in Penicillin Susceptible S. Aureus Bacteraemia |
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| Recruiting | 4 | 420 | Europe | Penicillin G_1200mg, bensylpenicillin, benzylpenicillin, cloxacillin | Region Skane | Staphylococcus Aureus Bacteraemia, Staphylococcal Bacteraemia, Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia), Staphylococcus (S.) Aureus Infection | 04/28 | 07/28 | | |
NCT05491200 / 2021-005499-20: Comparison Of Reduced DAPT Followed by P2Y12 Inhibitor Monotherapy With Prasugrel vs stAndard Regimen in STEMI Patients |
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| Recruiting | 4 | 1608 | Europe | Prasugrel based short DAPT, Prasugrel based standard DAPT, OCT guided revascularization, Angio guided revascularization | Research Maatschap Cardiologen Rotterdam Zuid, Abbott Medical Devices | ST Elevated Myocardial Infarction, Dual Antiplatelet Therapy | 08/26 | 08/28 | | |
| Recruiting | 3 | 325 | Europe | epirubicin, cyclophosphamide, paclitaxel, carboplatin, pembrolizumab, anthracycline, taxane, platinum, epirubicin, cyclophosphamide, capecitabine, paclitaxel, carboplatin, pembrolizumab, anthracycline, taxane, antimetabolite, platinum | Lund University Hospital, Swedish Breast Cancer Group, Danish Breast Cancer Cooperative Group | Breast Cancer, Triple Negative Breast Neoplasms | 07/25 | 06/35 | | |
NCT03897075: Efficacy and Safety Study of Tildrakizumab in the Treatment of Nail Psoriasis |
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| Active, not recruiting | 3 | 99 | US, RoW | Tildrakizumab, Placebo | Sun Pharmaceutical Industries Limited | Chronic Plaque Psoriasis, Moderate to Severe Nail Psoriasis | 04/24 | 02/25 | | |
NCT04569448: Brexpiprazole Treatment for Bipolar I Depression |
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| Recruiting | 3 | 58 | Canada | Brexpiprazole | Douglas Mental Health University Institute, McMaster University, Jewish General Hospital | Bipolar Depression | 02/25 | 02/25 | | |
NCT06799247: Investigating an mRNA CAR T-cell Therapy, Known as Descartes-08, as a Potential Approach to Treat Myasthenia Gravis |
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| Recruiting | 3 | 100 | US | Decartes-08, Placebo Drug | Cartesian Therapeutics | Myasthaenia Gravis | 04/26 | 04/26 | | |
| Recruiting | 3 | 170 | Europe, RoW | busulfan, cyclophosphamide and melphalan, BuCyMel, BuCyMel, clofarabine, fludarabine and busulfan, CloFluBu, CloFluBu | Vastra Gotaland Region | Acute Myeloid Leukemia (AML) in Remission, Stem Cell Transplantation | 12/29 | 12/31 | | |
NCT04257175: CAR-T CD19 for Acute Myelogenous Leukemia With t 8:21 and CD19 Expression |
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| Recruiting | 2/3 | 10 | RoW | CAR-T CD19 | Sheba Medical Center | Acute Myeloid Leukemia | 12/24 | 12/24 | | |
DIAN-TU, NCT05269394: Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation |
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| Active, not recruiting | 2/3 | 197 | Europe, Canada, Japan, US, RoW | E2814, Lecanemab, BAN2401, Matching Placebo (E2814) | Washington University School of Medicine, Alzheimer's Association, National Institute on Aging (NIA), Accelerating Medicines Partnership (AMP), Eisai Inc. | Alzheimers Disease, Dementia, Alzheimers Disease, Familial | 04/28 | 07/28 | | |
NCT03357159: Anti T-lymphocyte Immunoglobulin With Post Transplant Cyclophosphamide to Prevent GVHD Post Allogeneic Transplantation |
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| Recruiting | 2 | 30 | RoW | Cyclophosphamide, anti-human T-lymphocyte immunoglobulin (ATLG) | Sheba Medical Center | Graft Versus Host Disease | 12/24 | 12/24 | | |
NCT04221555: Trial of Neoadjuvant Durvalumab Plus Docetaxel, Oxaliplatin, S-1 Followed by Surgery and Adjuvant Durvalumab Plus S-1 Chemotherapy in Potentially Resectable MMR Proficient Gastric or Gastroesophageal Junction Adenocarcinoma |
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| Recruiting | 2 | 68 | RoW | Docetaxel, Oxaliplatin, S-1 and Durvalumab, Durvalumab and Tremelimumab | Asan Medical Center | Resectable Gastric or Gastroesophageal Junction Adenocarcinoma | 04/25 | 04/25 | | |
NCT05334823: A Study of pCAR-19B in the Treatment of CD19-positive Relapsed/Refractory B-ALL in Children and Adolescents |
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| Recruiting | 2 | 100 | RoW | pCAR-19B cells | Chongqing Precision Biotech Co., Ltd | Acute Lymphoblastic Leukemia, Relapsed Pediatric ALL, Refractory Acute Lymphoblastic Leukemia | 12/24 | 07/25 | | |
| Recruiting | 2 | 29 | RoW | Bisantrene, Fludarabine, Clofarabine | Sheba Medical Center, Race Oncology Ltd | Myelogenous Leukemia, Acute | 12/24 | 12/25 | | |
NCT06036784: Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of MBX 1416 in Healthy Subjects |
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| Completed | 1 | 69 | US | MBX 1416 (Part A), MBX 1416 (Part B), Placebo, MBX 1416 (Part C) | MBX Biosciences, ProSciento, Inc. | Postbariatric Hypoglycemia | 11/24 | 12/24 | | |
| Recruiting | N/A | 67 | Europe | mini invasive approach, Conventional approach | Institut Mutualiste Montsouris | Uterus Disease | 06/23 | 06/23 | | |
| Active, not recruiting | N/A | 150 | Europe | Lumbar medial branch cryo ablation neurotomy, Lumbar medial branch radiofrequency ablation neurotomy, Endoscopic denervation of fazet joint | Europainclinics z.ú., Slovak Academy of Sciences | Back Pain | 06/23 | 07/24 | | |
OPALE, NCT03058185: Observatoire Des Patients Atteints de Laminopathies et Emerinopathies (Observatory for PAtients With Laminopathies and Emerinopathies) |
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| Recruiting | N/A | 800 | Europe | | Pitié-Salpêtrière Hospital, Institute of Myology, Assistance Publique - Hôpitaux de Paris, Institut National de la Santé Et de la Recherche Médicale, France | Laminopathies, Emerinopathies | 07/33 | 07/33 | | |
NCT04211129: Effect of Acupuncture on Patients With Crohn's Disease in Remission |
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| Recruiting | N/A | 60 | RoW | acupuncture, Sham acupuncture | Shanghai Institute of Acupuncture, Moxibustion and Meridian, Fudan University, Ruijin Hospital, Shanghai Mental Health Center, Indiana University School of Medicine | Crohn Disease, Inflammatory Bowel Diseases | 12/24 | 12/24 | | |
NCT06166147: A Prospective Study of Liquid Biopsy for Pancreatic Cancer Early Detection |
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| Recruiting | N/A | 276 | RoW | | Fudan University, Shanghai Weihe Medical Laboratory Co., Ltd. | Pancreatic Cancer | 10/26 | 03/27 | | |
| Recruiting | N/A | 68 | Europe | Renal Denervation, Sham, Sham Procedure | University of Leipzig, ReCor Medical, Inc. | Heart Failure With Preserved Ejection Fraction, Hypertension, Renal | 12/24 | 03/26 | | |
| Not yet recruiting | N/A | 50 | Europe | Collection of joint fluid or tissue sample | Assistance Publique - Hôpitaux de Paris, Institut National de la Santé Et de la Recherche Médicale, France | Inflammatory and Non-inflammatory Bone and Joint Diseases | 04/27 | 09/27 | | |
NCT05927532: Argyle Safety Fistula Cannula With Anti-reflux Valve Clinical Study |
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| Active, not recruiting | N/A | 40 | US | Argyle Safety Fistula Cannula with Anti-Reflux Valve | Medtronic - MITG | End Stage Renal Failure on Dialysis | 12/24 | 12/24 | | |
GEM-1801, NCT03605771: Descriptive Observational Study on the Characteristics of Advanced and Metastatic Melanoma in Spain |
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| Recruiting | N/A | 400 | Europe | Daily Clinical Practice | Grupo Español Multidisciplinar de Melanoma | Melanoma Stage Iv, Melanoma Stage Iii, Advanced Cancer | 12/24 | 12/24 | | |
NCT05505201: Effectiveness of Transcranial Magnetic Stimulation in Subacute Stroke Patients With Severe Upper Limb Paresis |
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| Recruiting | N/A | 24 | RoW | Repetitive transcranial magnetic stimulation, Neuro Soft, Sham Repetitive transcranial magnetic stimulation | Izmir Katip Celebi University | Stroke Rehabilitation | 09/25 | 09/25 | | |
NCT03911128: A Treatment Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia |
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| Recruiting | N/A | 500 | Europe, RoW | Observational | Mats Heyman, Nordic Society for Pediatric Hematology and Oncology, The Swedish Childhood Cancer Foundation, NordForsk | Leukemia, Acute Lymphoblastic | 08/28 | 08/30 | | |
| Recruiting | N/A | 4000 | US | Survey | University of California, San Francisco | Pancreatic Cyst, Pancreatic Neoplasms, Pancreatic Cancer, Pancreatic Diseases, Pancreatic Intraductal Papillary Mucinous Neoplasm, Intraductal Papillary Mucinous Neoplasm, Pancreatic Ductal Adenocarcinoma, Mucinous Cyst | 01/30 | 01/30 | | |
| Recruiting | N/A | 1000 | Europe | Transcatheter heart valve (THV) with CE approval | Federico II University | Aortic Stenosis, Transcatheter Aortic Valve Replacement, TAVI | 09/21 | 01/30 | | |
| Restrepo, Jaramillo |
ARTISAN, NCT05203510: A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension |
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| Recruiting | 4 | 50 | US | Parenteral Treprostinil, Remodulin, Oral Treprostinil, Orenitram | United Therapeutics, Lung Biotechnology PBC | Pulmonary Arterial Hypertension | 12/25 | 12/27 | | |
| Jaramillo, Ricardo Restrepo |
ARTISAN, NCT05203510: A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension |
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| Recruiting | 4 | 50 | US | Parenteral Treprostinil, Remodulin, Oral Treprostinil, Orenitram | United Therapeutics, Lung Biotechnology PBC | Pulmonary Arterial Hypertension | 12/25 | 12/27 | | |
