University of California, Davis Medical Center
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 102 Trials 
311 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Smith, Karen
PREVENT-IT, NCT05084378 / 2022-000663-45: Evaluation of Emerging New Treatments for Infection Prevention in Total Joint Replacement

Active, not recruiting
3
500
Europe, Canada
Povidone-Iodine Lavage Solution, Chlorhexidine Lavage Solution, Topical Antibiotic, Saline Lavage Solution
Hamilton Health Sciences Corporation, McMaster University
Periprosthetic Joint Infection, Draining Wound
08/24
10/24
ARISE FLUIDS, NCT04569942: Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis

Recruiting
3
1000
RoW
Vasopressor, Fluids
Australian and New Zealand Intensive Care Research Centre
Shock, Septic
10/25
12/26
NCT02096588: Detection and Prevention of Anthracycline-Related Cardiac Toxicity With Concurrent Simvastatin

Terminated
2
34
US
Simvastatin, Zocor, Doxorubicin/cyclophosphamide, Adriamycin/Cytoxan
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Avon Foundation
Breast Cancer, Stage I Breast Cancer, Stage II Breast Cancer, Stage III Breast Cancer
04/17
07/23
NCT03043794: Study of Stereotactic Radiotherapy for Breast Cancer

Terminated
2
4
US
Stereotactic Body Radiation Therapy SBRT
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Robert L. Sloan Fund for Cancer Research
Breast Cancer
10/21
10/23
KEYNOTE B84, NCT04815720: Pepinemab in Combination With Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

Checkmark P1b data in combination with pepinemab for recurrent or metastatic HNSCC
Apr 2022 - Apr 2022: P1b data in combination with pepinemab for recurrent or metastatic HNSCC
Completed
1/2
49
US
pepinemab + pembrolizumab, KEYTRUDA®
Vaccinex Inc., Merck Sharp & Dohme LLC
Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (HNSCC)
07/24
07/24
NCT04972773: Spinal Cord Injury Mental Health Functional Outcomes Improved by Mindfulness

Completed
N/A
10
Canada
Mindfulness meditation (MM), Consumer app-based meditation, Insight timer, Healthy minds, Smiling mind
Queen's University
Spinal Cord Injuries, Mindfulness Meditation, Mental Health Wellness 1
03/23
03/23
NCT04482140: Post Approval Study to Evaluate the Safety and Performance of GENTA-FOIL Resorb® in Hand Surgery

Recruiting
N/A
55
Europe
Genta-Foil resorb®
Advanced Medical Solutions Ltd., Newcastle-upon-Tyne Hospitals NHS Trust, KAT General Hospital
Tissue Adhesions, Surgery-Induced
10/25
10/26
CHORUS, NCT06259292: Comprehensive HHT Outcomes Registry of the United States

Recruiting
N/A
10000
US
Cure HHT, Augusta University, The Cleveland Clinic, Mayo Clinic, Massachusetts General Hospital, Columbia University, Oregon Health and Science University, University of California, Los Angeles, University of California, San Francisco, University of Colorado, Denver, University of North Carolina, Chapel Hill, University of Pennsylvania, University of Texas, University of Utah, Washington University School of Medicine, Yale University, Health Resources and Services Administration (HRSA), Children's Hospital of Philadelphia
Hereditary Hemorrhagic Telangiectasia, Arteriovenous Malformations, Telangiectasia, Epistaxis, GastroIntestinal Bleeding, Cerebral Arteriovenous Malformations, Vascular Malformation
11/33
11/33
NCT02617056: Objective Assessment of Behavioral Associations of Patients With Dementia

Recruiting
N/A
60
US
VA Office of Research and Development, University of Massachusetts, Worcester
Dementia, Psychomotor Agitation
12/25
12/25
AIDI, NCT05713266: Using Data From a Multisensor Rapid Health Assessment Device to Predict Decompensation in Long COVID

Completed
N/A
204
US
MouthLabTM
Edith Nourse Rogers Memorial Veterans Hospital, AIDAR Health, Inc., Biomedical Advanced Research and Development Authority
COVID-19, Long COVID
01/24
02/24
NCT04209387: Novel EEG Coherence Biomarkers for PTSD Assessment

Active, not recruiting
N/A
66
US
VA Office of Research and Development, Portland VA Medical Center
PTSD
12/23
12/24
ACT-SS, NCT04567680: Acceptance and Commitment Therapy to Improve Social Support for Veterans With PTSD

Active, not recruiting
N/A
120
US
Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD, ACT-SS, Present-Centered Therapy, PCT
VA Office of Research and Development
Post-traumatic Stress Disorder
04/24
03/25
NCT01817192: Adjuvant Chemotherapy in Patients With Intermediate or High Risk Stage I or Stage IIA Non-squamous Non-Small Cell Lung Cancer

Recruiting
N/A
1050
Europe, US
Adjuvant Chemotherapy, Radiographic surveillance, 14-Gene Prognostic Assay
Razor Genomics, Encore Clinical
Non-Small Cell Lung Cancer
05/27
05/27
LEADS, NCT03507257: Longitudinal Early-onset Alzheimer's Disease Study Protocol

Recruiting
N/A
850
Europe, US, RoW
Flortaucipir, 18F-AV-1451 (also known as [F-18]T807 or LY3191748), Florbetaben, AV-45, Neuraceq, Fluorodeoxyglucose, FDG
Indiana University, Alzheimer's Therapeutic Research Institute, National Institute on Aging (NIA), Alzheimer's Association
Early Onset Alzheimer Disease, Alzheimer Disease, Mild Cognitive Impairment
05/25
05/25
REFLECTION, NCT05205967: A Clinical Practice Learning Program for Galleri®

Recruiting
N/A
17000
US
MCED, SOC
GRAIL, LLC
Early Detection of Cancer, Cancer
06/25
08/26
BVMN6203, NCT01158807: Cerebral Hemorrhage Risk in Hereditary Hemorrhagic Telangiectasia

Recruiting
N/A
1800
Europe, Canada, US
Unity Health Toronto, National Institute of Neurological Disorders and Stroke (NINDS)
Hereditary Hemorrhagic Telangiectasia
12/24
06/25
NCT03564730: Staged Versus Simultaneous Bilateral Knee Arthroplasty

Active, not recruiting
N/A
224
Canada
Simultaneous Knee Arthroplasty (UKA), Staged Knee Arthroplasty (UKA)
Orthopaedic Innovation Centre
Knee Osteoarthritis
11/25
12/26
BRAIVE IDE, NCT04929678: Study of the Braive Growth Modulation System for Progressive Pediatric Scoliosis

Active, not recruiting
N/A
10
Europe, Canada, US
Braive™ Growth Modulation System (Braive™ GMS)
Medtronic Spinal and Biologics, Medical Metrics Diagnostics, Inc
Juvenile Idiopathic Scoliosis, Adolescent Idiopathic Scoliosis
12/24
12/29
XPERIENCE, NCT05543941: Evaluating ™ Advanced Surgical Irrigation

Recruiting
N/A
7600
Canada
XPERIENCE Advanced Surgical Irrigation, XP, Dilute Betadine, DB, Providone-Iodine
Ottawa Hospital Research Institute, Next Science TM
Hip Osteoarthritis, Hip Arthritis, Knee Osteoarthritis, Knee Arthritis
03/27
12/27
Bowlus, Christopher L
NCT04950127 / 2021-000007-21: Global Linerixibat Itch Study of Efficacy and Safety in Primary Biliary Cholangitis (PBC) (GLISTEN)

Active, not recruiting
3
238
Europe, Canada, Japan, US, RoW
Linerixibat, Placebo
GlaxoSmithKline
Pruritus
10/24
01/25
LLSAT, NCT04167358 / 2019-003158-10: Linerixibat Long-term Safety, and Tolerability Study

Recruiting
3
251
Europe, Canada, Japan, US, RoW
Linerixibat
GlaxoSmithKline, GlaxoSmithKline LLC, GlaxoSmithKline Research & Development Limited
Cholestasis
02/27
02/27
SHIP, NCT03561584: Sulfasalazine for the Treatment of Primary Sclerosing Cholangitis

Recruiting
2
42
US
Sulfasalazine, Azulfidine, Placebo
Brigham and Women's Hospital
Primary Sclerosing Cholangitis
09/24
11/24
NCT05239468 / 2022-001241-20: Study of OCA in Combination With BZF Evaluating Efficacy, Safety and Tolerability in Participants With PBC

Active, not recruiting
2
60
US
Bezafibrate 100 mg, Bezafibrate 200 mg, Obeticholic Acid 5 mg, Obeticholic Acid placebo, Bezafibrate Placebo
Intercept Pharmaceuticals, Intercept Pharmaceuticals, Inc.
Primary Biliary Cholangitis
11/24
02/25
SPRING, NCT04595825 / 2019-002945-39: CM-101 in PSC Patients -The Study

Active, not recruiting
2
68
Europe, US, RoW
Anti-human CCL24 monoclonal antibody (CM-101), Placebo
ChemomAb Ltd., ChemomAb Ltd
Primary Sclerosing Cholangitis
09/24
09/25
VISTAS, NCT04663308 / 2020-003027-41: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

Recruiting
2
200
Europe, Canada, US, RoW
Volixibat, SHP626, Placebo
Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc.
Primary Sclerosing Cholangitis
09/25
12/25
NCT06699121: A Study to Assess the Safety and Efficacy of LB-P8 in Patients With PSC

Not yet recruiting
2
87
US
LB-P8 low-dose, LB-P8 high-dose, Placebo
LISCure Biosciences
Primary Sclerosing Cholangitis (PSC)
03/28
02/29
NCT04505436: Study to Evaluate Efficacy, Safety and Tolerability of HM15211 in Subjects

Recruiting
2
240
US, RoW
HM15211, Placebo of HM15211
Hanmi Pharmaceutical Company Limited
NASH - Nonalcoholic Steatohepatitis
05/26
11/26
HORIZON, NCT05583344 / 2022-002538-14: Phase 2b Study of GSK4532990 in Adults With NASH

Active, not recruiting
2
271
Europe, Canada, Japan, US, RoW
GSK4532990, Placebo
GlaxoSmithKline, GlaxoSmithKline Research & Development Limited
Nonalcoholic Fatty Liver Disease, Non-alcoholic Fatty Liver Disease
12/25
03/26
NCT05104853: Study to Evaluate the Safety, Tolerability, PDs, and Efficacy of CNP-104 in Subjects with Primary Biliary Cholangitis

Active, not recruiting
1/2
42
US
CNP-104, Placebo
COUR Pharmaceutical Development Company, Inc.
Primary Biliary Cholangitis
01/26
01/26
Wong, Michael
NCT06291857: A Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine and Influenza Combination Vaccine

Not yet recruiting
3
9320
RoW
CIC Vaccine Co-formulated tNIV2 , SARSCoV-2 rS and Matrix-M Adjuvant, COVID-19 and influenza combination, Novavax COVID-19 Vaccine, Novavax SARS-CoV-2 rS vaccine, tNIV Vaccine, Trivalent Nanoparticle Influenza Hemagglutinin Vaccine, Fluzone High Dose, Fluzone HD
Novavax
COVID-19
02/25
02/26
NCT03997435: FOLFOXIRI With or Without Intensification for Rectal Cancer

Recruiting
2
72
RoW
Control arm, Experimental arm
CCTU
Rectal Cancer
12/25
12/26
NCT06281678: A Study of IBI363 in Subjects with Advanced Solid Malignancies

Recruiting
2
178
US
IBI363
Innovent Biologics (Suzhou) Co. Ltd.
Melanoma, Non-small Cell Lung Cancer, Colorectal Cancer, Renal Cell Cancer
03/26
12/26
KEYNOTE-C86, NCT04993677 / 2021-002037-42: A Study of SEA-CD40 Given With Other Drugs in Cancers

Active, not recruiting
2
77
Europe, Canada, US
SEA-CD40, pembrolizumab (KEYTRUDA®), pemetrexed, Alimta, carboplatin, Paraplatin
Seagen Inc., Merck Sharp & Dohme LLC
Melanoma, Carcinoma, Non-Small- Cell Lung
01/24
10/25
IGNYTE, NCT03767348 / 2016-004548-12: Study of RP1 Monotherapy and RP1 in Combination With Nivolumab

Hourglass Jan 2024 - Mar 2024 : Data from IGNYTE trial in combination with Opdivo for 2L melanoma
Checkmark From P2 portion of P1/2 trial in combination with RP1 for solid tumors at SITC 2020
Nov 2020 - Nov 2020: From P2 portion of P1/2 trial in combination with RP1 for solid tumors at SITC 2020
Checkmark Initial data from P1 portion of trial in combination with RP1 at SITC 2019
Nov 2019 - Nov 2019: Initial data from P1 portion of trial in combination with RP1 at SITC 2019
Recruiting
2
340
Europe, US
RP1, nivolumab, Opdivo
Replimune Inc., Bristol-Myers Squibb
Cancer, Melanoma (Skin), Mismatch Repair Deficiency, Microsatellite Instability, Non-melanoma Skin Cancer, Cutaneous Melanoma, NSCLC
12/25
12/28
TSC-STEPS, NCT05104983: Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study

Recruiting
2
64
US
Sirolimus, Placebo
Darcy Krueger
Tuberous Sclerosis Complex, Epilepsy
06/25
06/26
NCT06680128: A Study to Assess the Safety, Reactogenicity, and Immunogenicity of SK Japanese Encephalitis Messenger Ribonucleic Acid (mRNA) Vaccines (GBP560) in Healthy Adults

Not yet recruiting
1/2
402
RoW
GBP560-A, GBP560-B, IXIARO, IMOJEV, Normal Saline (Placebo)
SK Bioscience Co., Ltd.
Japanese Encephalitis Virus Disease
06/26
03/28
NCT05620940: A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.

Recruiting
1
40
RoW
Vivitrol Injectable Product, IVL3004, IVL4002
Inventage Lab., Inc.
Opioid Dependence, Alcohol Dependence
05/25
05/25
NCT05831995: Safety and Effectiveness of ABM-168 in Adults with Advanced Solid Tumors.

Terminated
1
12
US
ABM-168
ABM Therapeutics Corporation
Advanced Solid Tumor, RAS Mutation, RAF Mutation, NF1 Mutation
06/24
06/24
NCT05676099: TSC Biosample Repository and Natural History Database

Recruiting
N/A
5000
Canada, US
Phlebotomy, Buccal (cheek) swab, Genetic Testing, Tissue donation after routine clinical procedure
National Tuberous Sclerosis Association
Tuberous Sclerosis, Lymphangioleiomyomatosis
12/50
12/50
Rogers, Jason
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
05/24
06/28
NCT05061004: Cephea Early Feasibility Study

Recruiting
N/A
50
Canada, US
Cephea Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation
03/26
03/31
FPP, NCT06672874: Fermented Papaya and Driving Simulator Older Adult Study

Not yet recruiting
N/A
30
US
Fermented Papaya Preparation (FPP)
University of Florida, Osato Research Institute
Healthy
03/26
05/26
Badawi, Ramsey
NCT04020978: Parametric PET of Genitourinary Cancer

Completed
N/A
11
US
Parametric PET/CT
University of California, Davis
Genitourinary Cancer
01/23
12/23
NCT02754037: Non-alcoholic Fatty Liver Disease Parametric PET (FLiPP) Study

Active, not recruiting
N/A
120
US
Fluorodeoxyglucose (FDG) positron emission tomography (PET), Magnetic resonance imaging (MRI), Magnetic resonance proton density fat fraction (MR-PDFF), Magnetic resonance elastography (MRE), PET Explorer
University of California, Davis, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Non-alcoholic Fatty Liver Disease (NAFLD), Non-alcoholic Steatohepatitis (NASH)
06/25
06/25
Fleming, Neal W
NCT05478174: Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia

Completed
3
400
US
HSK3486, Propofol, Diprivan
Haisco-USA Pharmaceuticals, Inc.
General Anesthesia
11/23
11/23
NCT03075150: PVI as a Parameter to Predict Fluid Responsiveness

Recruiting
N/A
100
US
Masimo Rainbow sensor
University of California, Davis, Masimo Corporation
Surgery
07/19
07/19
NCT04730063: Evaluation of Novel Cardio-Pulmonary Physiological Monitor, the VQm PHM™, for Acute Care Medicine

Recruiting
N/A
40
US
VQm PHM™
Rostrum Medical Innovations Inc., University of California, Davis
Elective Procedures Requiring Mechanical Ventilation
01/23
02/23
NCT05025176: Hypotension Prediction Index: Correlations Between Invasive and Non-invasive Pressure Points.

Active, not recruiting
N/A
50
US
Non invasive arterial pressure monitoring
University of California, Davis
Hypotension
08/25
08/25
NCT05859672: Ventilation and Esophageal Pressure Changes

Recruiting
N/A
150
US
University of California, Davis
Mechanical Ventilation
01/25
01/25
NCT04726852: Arterial Pressure vs. TE Echo dp/dt

Active, not recruiting
N/A
43
US
Concurrent comparison
University of California, Davis
Myocardial Contraction
01/25
07/25
NCT05886218: Quantitative Neuromuscular Monitoring and Gastric Bypass Surgery

Recruiting
N/A
215
US
Quantitative Neuromuscular Function Monitoring
University of California, Davis
Sugammadex
02/25
07/25
NCT01997502: Accuracy of Pulse CO-Oximetry Technology in Characterizing Noninvasive SpHb

Recruiting
N/A
300
US
Pulse CO-Oximetry Technology, Blood draw
University of California, Davis
Surgery, Hemoglobin
01/25
01/25
NCT01815983: Video-Assisted Laryngoscopy Education

Withdrawn
N/A
40
US
Videolaryngoscopy review.
University of California, Davis
Surgery
06/24
06/24
Teirstein, Paul S
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting
N/A
1400
Europe, US, RoW
Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation
Medtronic Vascular
Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus
11/26
11/29
NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting
N/A
1948
Canada, US
ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL
Boston Scientific Corporation
Aortic Stenosis
06/24
09/34
Underwood, Mark
IMPRINT, NCT02457338: Infant Microbiota and Probiotic Intake Study

Active, not recruiting
N/A
120
US
Bifidobacterium, B. infantis
University of California, Davis, Evolve BioSystems, Inc.
Healthy
07/16
06/27
NCT03717584: A Cohort Study of the Intestinal Microbiota of Premature Infants

Active, not recruiting
N/A
300
US
University of California, Davis
Necrotizing Enterocolitis, Bronchopulmonary Dysplasia, Growth Failure
12/24
12/26
Yoneda, Ken
SPRAY-CB, NCT03893370: RejuvenAir® System Trial for COPD With Chronic Bronchitis

Active, not recruiting
N/A
210
Europe, US
RejuvenAir System, Sham Control Procedure
CSA Medical, Inc.
Chronic Bronchitis
05/25
09/26
RheSolve, NCT04677465: Clinical Study of the RheOx Bronchial Rheoplasty System in Treating the Symptoms of Chronic Bronchitis

Active, not recruiting
N/A
270
Europe, US
RheOx Bronchial Rheoplasty, Sham Procedure
Gala Therapeutics, Inc.
Chronic Bronchitis
05/24
10/25
AIRFLOW-3, NCT03639051: Evaluation of the Safety and Efficacy of TLD in Patients with COPD

Active, not recruiting
N/A
464
Europe, US
Targeted Lung Denervation (TLD), TLD, TLD Therapy, Optimal Medical Care
Nuvaira, Inc.
COPD
10/24
09/28
Bold, Richard J
NCT04379570: Additional Support Program Via Text Messaging and Telephone-Based Counseling for Breast Cancer Patients Receiving Hormonal Therapy

Recruiting
3
1180
US
Educational Intervention, Text Message-based Navigation Intervention, Motivational Interviewing, Best Practice, Standard of Care, Questionnaire Administration, Quality-of-Life Assessment
Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI)
Anatomic Stage I Breast Cancer AJCC V8, Anatomic Stage II Breast Cancer AJCC V8, Anatomic Stage III Breast Cancer AJCC V8, HER2 Negative Breast Carcinoma, Hormone Receptor Positive Breast Carcinoma, Invasive Breast Carcinoma, Prognostic Stage I Breast Cancer AJCC V8, Prognostic Stage II Breast Cancer AJCC V8, Prognostic Stage III Breast Cancer AJCC V8
10/26
10/26
GUIDANCE, NCT05050084: Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score

Recruiting
3
2050
Canada, US
Bicalutamide, Casodex, Cosudex, ICI 176,334, ICI 176334, Buserelin, 6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing Hormone-releasing Factor (Pig), BSRL, Busereline, Etilamide, HOE 766, ICI 123215, S74-6766, Darolutamide, Antiandrogen ODM-201, BAY 1841788, BAY-1841788, BAY1841788, Nubeqa, ODM 201, ODM-201, Degarelix, FE200486, Firmagon, Flutamide, 4'-Nitro-3'-trifluoromethylisobutyranilide, Apimid, Cebatrol, Chimax, Cytomid, Drogenil, Euflex, Eulexine, Flucinom, Flucinome, Flugerel, Fluken, Flulem, FLUT, Fluta-Gry, Flutabene, Flutacan, Flutamex, Flutamin, Flutan, Flutaplex, Fugerel, Grisetin, Niftolide, Oncosal, Profamid, Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-, Prostacur, Prostadirex, Prostica, Prostogenat, Sch 13521, Tafenil, Tecnoflut, Testotard, Goserelin, ICI-118630, Histrelin, Leuprolide, Leuprorelin, Radiation Therapy, Cancer Radiotherapy, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Relugolix, N-(4-(1-((2,6-Difluorophenyl)methyl)-5-((dimethylamino)methyl)-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno(2,3-d)pyrimidin-6-yl)phenyl)-N'-methoxyurea, Orgovyx, TAK 385, TAK-385, Triptorelin, 6-D-Tryptophan-LH-RH, 6-D-Tryptophanluteinizing Hormone-releasing Factor, AY-25650, CL-118,532, Detryptoreline
NRG Oncology, National Cancer Institute (NCI)
Prostate Adenocarcinoma
04/32
04/37
NCT04137107: Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients with Stage II-III Colorectal Cancer

Active, not recruiting
2/3
220
US, RoW
Oxaliplatin, Duloxetine Hydrochloride, Duloxetine, Quality-of-Life Assessment, Questionnaire Administration, Placebo
Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI)
Stage II Colorectal Cancer AJCC V8, Stage III Colorectal Cancer AJCC V8
02/26
12/26
CIRCULATE-US, NCT05174169: Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

Recruiting
2/3
1912
Canada, US
Signatera test, mFOLFOX6 3-6 month, CAPOX 3 month, mFOLFIRINOX, mFOLFOX6 6 month, CAPOX 6 month
NRG Oncology, Natera, Inc., National Cancer Institute (NCI)
Stage III Colon Cancer
03/29
03/30
A222001, NCT04600336: Testing the Effects of Oxybutynin for the Treatment of Hot Flashes in Men Receiving Hormone Therapy for Prostate Cancer

Completed
2
88
US
Oxybutynin Chloride, Placebo Administration, Quality-of-Life Assessment, Questionnaire Administration
Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI)
Prostate Carcinoma
02/24
03/24
NCT04310007: Testing the Addition of the Pill Chemotherapy, Cabozantinib, to the Standard Immune Therapy Nivolumab Compared to Standard Chemotherapy for Non-small Cell Lung Cancer

Active, not recruiting
2
117
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Cabozantinib S-malate, BMS-907351, Cabometyx, Cometriq, XL 184, XL-184, XL184, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Docetaxel, Docecad, RP 56976, RP-56976, RP56976, Taxotere, Taxotere Injection Concentrate, Echocardiography, EC, Gemcitabine Hydrochloride, dFdCyd, Difluorodeoxycytidine Hydrochloride, Gemcitabine HCI, Gemzar, LY 188011, LY-188011, LY188011, Nab-paclitaxel, ABI 007, ABI-007, ABI007, Abraxane, Albumin-bound Paclitaxel, Albumin-Stabilized Nanoparticle Paclitaxel, Nanoparticle Albumin-bound Paclitaxel, Nanoparticle Paclitaxel, Naveruclif, Paclitaxel Albumin, paclitaxel albumin-stabilized nanoparticle formulation, Paclitaxel Nanoparticle Albumin-bound, Paclitaxel Protein-Bound, Protein-bound Paclitaxel, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Ramucirumab, Anti-VEGFR-2 Fully Human Monoclonal Antibody IMC-1121B, Cyramza, IMC 1121B, IMC-1121B, IMC1121B, LY 3009806, LY-3009806, LY3009806, Monoclonal Antibody HGS-ETR2
National Cancer Institute (NCI)
Metastatic Lung Non-Squamous Non-Small Cell Carcinoma, Recurrent Lung Non-Squamous Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
06/25
06/25
NCT04266249: CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

Recruiting
2
2156
US
Docetaxel, Docecad, RP56976, Taxotere, Taxotere Injection Concentrate, Lumpectomy, Lumpectomy of Breast, Partial Mastectomy, Mastectomy, Mammectomy, Nab-paclitaxel, ABI 007, ABI-007, Abraxane, Albumin-bound Paclitaxel, Albumin-Stabilized Nanoparticle Paclitaxel, Nanoparticle Albumin-bound Paclitaxel, Nanoparticle Paclitaxel, Paclitaxel Albumin, paclitaxel albumin-stabilized nanoparticle formulation, protein-bound paclitaxel, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Pertuzumab, 2C4, 2C4 Antibody, MoAb 2C4, Monoclonal Antibody 2C4, Omnitarg, Perjeta, rhuMAb2C4, RO4368451, Radiation Therapy, Cancer Radiotherapy, Irradiate, irradiated, irradiation, RADIATION, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Trastuzumab, ABP 980, ALT02, Anti-c-ERB-2, Anti-c-erbB2 Monoclonal Antibody, Anti-ERB-2, Anti-erbB-2, Anti-erbB2 Monoclonal Antibody, Anti-HER2/c-erbB2 Monoclonal Antibody, Anti-p185-HER2, c-erb-2 Monoclonal Antibody, HER2 Monoclonal Antibody, Herceptin, Herceptin Biosimilar PF-05280014, Herceptin Trastuzumab Biosimilar PF-05280014, Herzuma, MoAb HER2, Monoclonal Antibody c-erb-2, Monoclonal Antibody HER2, Ogivri, Ontruzant, PF-05280014, rhuMAb HER2, RO0452317, SB3, Trastuzumab Biosimilar ABP 980, Trastuzumab Biosimilar ALT02, trastuzumab biosimilar EG12014, Trastuzumab Biosimilar HLX02, Trastuzumab Biosimilar PF-05280014, Trastuzumab Biosimilar SB3, Trastuzumab-dkst, Trastuzumab-dttb, Trastuzumab-pkrb, Trastuzumab-QYYP, Trazimera, Trastuzumab Emtansine, Ado Trastuzumab Emtansine, ADO-Trastuzumab Emtansine, Kadcyla, PRO132365, RO5304020, T-DM1, Trastuzumab-DM1, Trastuzumab-MCC-DM1, Trastuzumab-MCC-DM1 Antibody-Drug Conjugate, Trastuzumab-MCC-DM1 Immunoconjugate
ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Invasive Breast Carcinoma, Prognostic Stage II Breast Cancer AJCC v8, Prognostic Stage IIA Breast Cancer AJCC v8, Prognostic Stage IIB Breast Cancer AJCC v8, Prognostic Stage IIIA Breast Cancer AJCC v8
10/26
12/38
SWOG-S1703, NCT03723928: S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

Recruiting
N/A
739
US, RoW
Usual care disease monitoring, Serum Tumor Marker directed disease monitoring, STMDDM, Quality-of-Life Assessment, Quality of Life Assessment, Anxiety Questionnaire Administration
SWOG Cancer Research Network, National Cancer Institute (NCI)
Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive, HER2/Neu Negative, Progesterone Receptor Positive, Prognostic Stage IV Breast Cancer AJCC v8, Elevated CA15-3 or CEA or CA27-29
12/30
12/36
Huang, Susan
PROTECT, NCT03118232: Project Protecting Nursing Homes From Infections and Hospitalization

Completed
4
13952
US
Chlorhexidine gluconate (CHG), Iodophor (10% povidone-iodine)
University of California, Irvine, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, University of Massachusetts, Amherst, Agency for Healthcare Research and Quality (AHRQ)
Hospitalization, Infection
10/23
10/23
NCT03140423: Mupirocin-Iodophor ICU Decolonization Swap Out Trial

Completed
4
353323
US
Arm 1. Routine Care (Mupirocin/CHG), Arm 2. Iodophor/CHG Decolonization
Harvard Pilgrim Health Care, Hospital Corporation of America, University of California, Irvine, University of Massachusetts, Amherst, Rush University, Centers for Disease Control and Prevention
Staphylococcus Aureus
11/23
11/23
DECREASE SSI, NCT05586776: Decolonization to Reduce After-Surgery Events of Surgical Site Infection

Recruiting
4
2700
US
4% Chlorhexidine Gluconate, 2% Mupirocin, Soap Without Antiseptic Properties (Placebo), Placebo Nasal Ointment
University of California, Irvine, University of California, Davis, University of California, San Francisco, University of Massachusetts, Amherst, Hoag Memorial Hospital Presbyterian
Surgical Site Infection
12/27
12/28
NCT05714969 / 2022-001940-36: A Study of TAK-755 (rADAMTS13) With Little to No Plasma Exchange (PEX) Treatment in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP)

Active, not recruiting
2
40
Europe, US, RoW
TAK-755, rADAMTS13, recombinant ADAMTS13, SHP-655, BAX 930
Takeda, Takeda Development Center Americas, Inc.
Thrombotic Thrombocytopenic Purpura (TTP)
03/25
03/25
INSPIRE-ASP PNA, NCT03697070: The Trial

Completed
N/A
44780
US
INSPIRE CPOE Smart Prompt, Routine Care
Harvard Pilgrim Health Care, Hospital Corporation of America Healthcare (HCA), University of California, Irvine, University of Massachusetts, Amherst, Brigham and Women's Hospital, Centers for Disease Control and Prevention
Pneumonia
05/24
05/24
NCT03697096: The INSPIRE-ASP UTI Trial

Completed
N/A
55412
US
Routine Care, INSPIRE CPOE Smart Prompt
Harvard Pilgrim Health Care, Hospital Corporation of America, University of California, Irvine, University of Massachusetts, Amherst, Brigham and Women's Hospital, Centers for Disease Control and Prevention
Urinary Tract Infection (UTI)
05/24
05/24
NCT06386874: EMAGINE 2.0 - Electromagnetic Field Ischemic Stroke - Novel Subacute Treatment

Recruiting
N/A
122
US
Q Therapeutic System (BQ 3.0) - Sham, BQ 3.0 Sham Stimulation Group, Q Therapeutic System (BQ 3.0) - Active, BQ 3.0 Active Stimulation Group Interventions
BrainQ Technologies Ltd.
Ischemic Stroke
07/26
10/26
CLUSTER, NCT04053075: Trial for Outbreak Detection and Response

Completed
N/A
2905455
US
Routine cluster detection, Enhanced cluster detection
Harvard Pilgrim Health Care, Hospital Corporation of America (HCA) Healthcare, Brigham and Women's Hospital, University of California, Irvine, Harvard School of Public Health (HSPH), Rush University, Duke University, University of Massachusetts, Amherst, University of California, San Francisco, Cook County Health & Hospitals System, Centers for Disease Control and Prevention
Cluster Detection
05/24
05/24
NCT05423756: INSPIRE Trial for Skin and Soft Tissue Infections

Active, not recruiting
N/A
102
US
Arm 1: Routine Care, Arm 2: INSPIRE Stewardship Bundle for Skin and Soft Tissue Infection
Harvard Pilgrim Health Care, HCA Healthcare, Inc, University of California, Irvine, University of Massachusetts, Amherst, Brigham and Women's Hospital, Rush University
Skin and Soft Tissue (SST) Infection
12/27
12/28
NCT05423743: INSPIRE Trial for Abdominal Infections

Active, not recruiting
N/A
102
US
Arm 1: Routine Care, Arm 2: INSPIRE Stewardship Bundle for Abdominal Infection
Harvard Pilgrim Health Care, HCA Healthcare, Inc, University of California, Irvine, University of Massachusetts, Amherst, Brigham and Women's Hospital, Rush University
Abdominal (ABD) Infection
12/27
12/28
Kuppermann, Nathan
TIC-TOC, NCT04387305: Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: An Efficacy Study

Not yet recruiting
3
2000
NA
Tranexamic acid injection
Daniel Nishijima, MD, MAS, Pediatric Emergency Care Applied Research Network
Brain Injuries, Traumatic, Wounds and Injury, Hemorrhage, Trauma Injury
03/30
03/30
FAST, NCT05910567: A Research Study of Abdominal Ultrasound () in Children With Blunt Torso Trauma

Recruiting
N/A
4346
US
Focused Assessment with Sonography for Trauma (FAST) Examination, Abdominal Ultrasound, No Intervention: Standard of Care - Without the FAST Examination
James F. Holmes, MD, MPH, Pediatric Emergency Care Applied Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Blunt Trauma to Abdomen, Wounds and Injuries, Abdomen Injury, Abdominal Injury, Abdomen, Acute
04/27
04/27
May, Larissa S
SEPSIS-SHIELD, NCT04094818: TriVerity in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections and Suspected Sepsis

Completed
N/A
1441
Europe, US
TriVerity, InSep, HostDx Sepsis
Inflammatix
Respiratory Tract Infections, Urinary Tract Infections, Intra-Abdominal Infections, Skin and Soft Tissue Infection, Suspected Meningitis/Encephalitis or Any Other Infection, Sepsis
08/24
09/24
Holmes, James F
NCT03564795: Effectiveness of KeraStat Gel for Improved Cosmesis of Partial Thickness Burns

Terminated
N/A
14
US
KeraStat Gel, Silver Sulfadiazine, SSD
KeraNetics, LLC, Wake Forest University, United States Department of Defense
Partial-thickness Burn
03/23
03/23
STAT, NCT04368117: Standard Therapy Plus Active Therapy

Recruiting
N/A
166
US
Physical Therapy
American Burn Association, United States Department of Defense
Burn Injury, Physical Injury, Thermal Burn
08/25
09/25
ABRUPT2, NCT04356859: The Acute Burn ResUscitation Multicenter Prospective Trial

Recruiting
N/A
400
Canada, US
Albumin Human, albumin
American Burn Association, United States Department of Defense
Burn Injury
08/25
09/25
QUANTIFY, NCT06803056: Quantitative Understanding of Advanced Novel Techniques for Imaging Fasciitis and Yielding Biomarkers

Not yet recruiting
N/A
120
US
Clinical exam, Ultrasound imaging, Magnetic Resonance Imaging
Ruth Chimenti, National Center for Complementary and Integrative Health (NCCIH), Rochester Institute of Technology
Plantar Fasciopathy, Achilles Tendinopathy, Controls
07/26
08/26
NCT05704062: Quantitative MRI Assessment of Breast Cancer Therapy Response

Recruiting
N/A
135
US
Diffusion Weighted Imaging, Diffusion Weighted MRI, Diffusion-Weighted Magnetic Resonance Imaging, Diffusion-Weighted MR Imaging, Diffusion-Weighted MRI, DW-MRI, DWI, DWI MRI, DWI-MRI, MR Diffusion-Weighted Imaging, Dynamic Contrast-Enhanced Magnetic Resonance Imaging, DCE, DCE MRI, DCE-MRI, DYNAMIC CONTRAST ENHANCED MRI
OHSU Knight Cancer Institute, National Cancer Institute (NCI), University of Washington, University of Iowa, Oregon Health and Science University
Breast Cancer
11/26
11/26
FAST, NCT05910567: A Research Study of Abdominal Ultrasound () in Children With Blunt Torso Trauma

Recruiting
N/A
4346
US
Focused Assessment with Sonography for Trauma (FAST) Examination, Abdominal Ultrasound, No Intervention: Standard of Care - Without the FAST Examination
James F. Holmes, MD, MPH, Pediatric Emergency Care Applied Research Network, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Blunt Trauma to Abdomen, Wounds and Injuries, Abdomen Injury, Abdominal Injury, Abdomen, Acute
04/27
04/27
Smilowitz, Jennifer T
NCT01803633: Determine How Consumption of Dairy Fat as Cheese Influences Inflammation-Phase 2

Active, not recruiting
N/A
20
US
Cheddar cheese, Vegan cheese
University of California, Davis, Dairy Research Institute
Metabolic Syndrome, Obesity
08/13
01/27
NCT01811329: Determine How Consumption of Dairy Fat Fractions Rich in Phospholipids and Proteins Influence Inflammation in the Fed State-Phase 1

Active, not recruiting
N/A
38
US
Dairy fat, Dairy fat + MFGM, Palm fat, Palm fat + MFGM
University of California, Davis, Dairy Research Institute
Metabolic Syndrome, Obesity
06/14
01/27
NCT01817127: Elucidation of Breast Milk Composition and Structure Over the First Year of Lactation: UC Davis Lactation Study

Active, not recruiting
N/A
395
US
University of California, Davis, California Dairy Research Foundation
Healthy, Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus
02/15
09/28
IMPRINT, NCT02457338: Infant Microbiota and Probiotic Intake Study

Active, not recruiting
N/A
120
US
Bifidobacterium, B. infantis
University of California, Davis, Evolve BioSystems, Inc.
Healthy
07/16
06/27
IMiND, NCT03229863: An Examination of Infants' Microbiome, Nutrition, and Development Study.

Active, not recruiting
N/A
102
US
Sweet Potatos, Pears
University of California, Davis, UC Davis Foods for Health Institute, Mengniu Dairy
Microbial Colonization, Infant Development
03/20
03/27
FEEDMe, NCT06395324: Fiber Effectively Educates & Directs the Microbiome Study

Recruiting
N/A
48
US
High arabinose diet
University of California, Davis, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Microbial Colonization
05/25
12/25
Shahlaie, Kiarash
NCT04716699: Systemic and Local Levels of Lidocaine During Surgery for the Removal of Glioblastoma

Completed
1
12
US
Biospecimen Collection, Lidocaine, .omega.-Diethylamino-2,6-dimethylacetanilide, 2-(Diethylamino)-2'',6''-acetoxylidide, Cuivasil, Duncaine, Leostesin, Lidothesin, Lignocaine, Rucaina, Resection, Surgical Resection
Kiarash Shahlaie, M.D., Ph.D., National Cancer Institute (NCI)
Glioblastoma
12/21
01/22
NCT04650932: Dual Frequency Stimulation in Parkinson's Disease

Recruiting
N/A
10
US
Deep brain stimulation, Boston Scientific Vercise DBS
University of California, Davis
Parkinson Disease
12/24
12/24
PENS, NCT05081128: Efficacy in iNPH Shunting () Trial

Active, not recruiting
N/A
100
Europe, Canada, US
programmable CSF shunt valve, FDA-approved Certas Plus with Siphonguard
Johns Hopkins University, National Institute of Neurological Disorders and Stroke (NINDS)
Idiopathic Normal Pressure Hydrocephalus (INPH)
05/26
08/27
Wang-Polagruto, Janice
NCT03118505: A Study of Infuse® Bone Graft With Mastergraft® Strip and Posterior Fixation for Posterolateral Fusion (PLF) Treatment of Multi-Level Degenerative Lumbosacral Spinal Conditions

Active, not recruiting
N/A
100
US
Infuse Bone Graft, Medtronic DBM
Medtronic Spinal and Biologics
Multi-Level Degenerative Lumbosacral Spinal Conditions
04/26
12/26
NCT06485206: Evaluation of Safety and Effectiveness of Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two-level Symptomatic Degenerative Disc Disease in the Cervical Spine.

Recruiting
N/A
97
US
One level Mobi-C and one level fusion, Mobi-C Hybrid
Highridge Medical
Degenerative Disc Disease
05/29
05/29
NCT04650932: Dual Frequency Stimulation in Parkinson's Disease

Recruiting
N/A
10
US
Deep brain stimulation, Boston Scientific Vercise DBS
University of California, Davis
Parkinson Disease
12/24
12/24
TLIF, NCT04073563: Transforaminal Lumbar Interbody Fusion

Recruiting
N/A
1017
US, RoW
Infuse™ Bone Graft (Infuse™), Intervertebral body fusion device and Medtronic posterior Fixation Systems
Medtronic Spinal and Biologics
Degenerative Disease of the Lumbosacral Spine
04/26
04/28
 

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