| Dichgans, Martin |
| Terminated | 3 | 101 | Europe | Amlodipine, Losartan, Atenolol | Ludwig-Maximilians - University of Munich, University of Edinburgh, Maastricht University Medical Center, UMC Utrecht, University of Oxford | Cerebral Small Vessel Diseases | 07/22 | 07/22 | | |
ReSCInD, NCT05880524: Reduction of SystemiC Inflammation After Ischemic Stroke by Intravenous DNase Administration |
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| Not yet recruiting | 2 | 36 | Europe | Dornase Alfa, Pulmozyme, Isotonic Saline Solution, NaCl 0,9% | Ludwig-Maximilians - University of Munich, University Hospital Erlangen, University Hospital Regensburg | Ischemic Stroke, Inflammatory Response | 12/25 | 01/26 | | |
| Recruiting | N/A | 75 | Europe | MR Imaging | Martin Dichgans | Cerebral Amyloid Angiopathy | 03/25 | 03/26 | | |
| Recruiting | N/A | 36 | Europe | [18F]-GE-180 PET, TSPO PET imaging, 3T MRI, immune cell profiling in blood | Martin Dichgans, Universitätsklinikum Hamburg-Eppendorf, University Hospital Muenster | Ischemic Stroke | 12/24 | 12/25 | | |
| Recruiting | N/A | 850 | Europe | | Ludwig-Maximilians - University of Munich, Charite University, Berlin, Germany | Ischemic Stroke | 12/24 | 12/27 | | |
DISTAL, NCT05029414: EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke |
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| Active, not recruiting | N/A | 543 | Europe, RoW | Endovascular Therapy | University Hospital, Basel, Switzerland, Swiss National Fund for Scientific Research, Stryker Neurovascular, Penumbra Inc., Medtronic, Phenox GmbH, Rapid Medical, Gottfried und Julia Bangerter-Rhyner-Stiftung | Acute Ischemic Stroke | 10/24 | 06/25 | | |
| Recruiting | N/A | 10000 | Europe | telephone call d90 | Universitätsklinikum Hamburg-Eppendorf, University Hospital of Cologne, Klinikum rechts der Isar, Technical University of Munich, RWTH Aachen University, University Hospital Tuebingen, Charite University, Berlin, Germany, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Sana Klinikum Offenbach, Goethe University, Klinikum Dortmund, KRH Klinikum Nordstadt, Asklepios Klinik Altona, Klinikum Altenburger Land, Klinikum Stadt Hanau, Klinikum Lüneburg, Ludwig-Maximilians - University of Munich, University of Göttingen, Krankenhaus Buchholz, Klinikum Osnabrück, Wuerzburg University Hospital, University of Giessen and Marburg, Sana Kliniken Lübeck, Mühlenkreiskliniken Minden, radprax MVZ Nordrhein, University Hospital Muenster, University Medical Center Rostock, Asklepios Klinik Wandsbek, Elbe Kliniken, Städtische Klinikum Braunschweig, Allgemeines Krankenhaus Celle, Bezirkskrankenhaus Günzburg, Klinikum Bremen-Mitte, gGmbH, University Medical Center Mainz, Klinikum Köln-Merheim, University Hospital, Bonn | Acute Ischemic Stroke | 06/27 | 06/27 | | |
Find-AF2, NCT04371055: Intensive Rhythm Monitoring to Decrease Ischemic Stroke and Systemic Embolism - the Find-AF 2 Study |
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| Recruiting | N/A | 5200 | Europe | 7-day Holter ECG, Implantable cardiac monitor, Standard of care | University of Leipzig, Johannes Gutenberg University Mainz | Ischemic Stroke, Atrial Fibrillation | 06/26 | 12/26 | | |
| Active, not recruiting | N/A | 736 | Europe | | Ludwig-Maximilians - University of Munich | Ischemic Stroke, Hemorrhagic Stroke | 01/29 | 01/29 | | |
| Massberg, Steffen |
EPIDAURUS, NCT04981041: Escalated Single Platelet Inhibition for One Month Plus NOAC in Patients With Atrial Fibrillation and ACS Undergoing PCI |
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| Recruiting | 4 | 2334 | Europe | Prasugrel or Ticagrelor, Clopidogrel | Ludwig-Maximilians - University of Munich | Acute Coronary Syndrome, Atrial Fibrillation | 12/24 | 06/25 | | |
| Active, not recruiting | N/A | 607 | Europe | Withings ScanWatch | Ludwig-Maximilians - University of Munich, Gesundheitsreferat (GSR), Landeshauptstadt München, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) | Covid-19, Cardiovascular Risk Factor | 06/22 | 06/23 | | |
IMPROVE-OCT, NCT03079791: Impact of Level and Quality of Immunosuppression on Onset and Pattern of Cardiac Allograft Vasculopathy Evaluated by OCT |
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| Completed | N/A | 100 | Europe | | LMU Klinikum | Transplant; Failure, Heart | 01/23 | 01/23 | | |
EUROSHOCK, NCT03813134: Testing the Value of Novel Strategy and Its Cost Efficacy in Order to Improve the Poor Outcomes in Cardiogenic Shock |
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| Recruiting | N/A | 428 | Europe | Percutaneous coronary intervention (PCI), Pharmacological Support, VA-ECMO, Veno-Arterial Extra Corporeal Membrane Oxygenation. | University of Leicester, European Commission, University of Glasgow, KU Leuven, University of East Anglia, Deutsches Herzzentrum Muenchen, A.O. Ospedale Papa Giovanni XXIII, Chalice Medical Ltd, Ludwig-Maximilians - University of Munich, University of Tromso, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Paula Stradina Liniska Universitates, Accelopment AG, Universiteit Antwerpen, Cardiovascular European Research Centre (CERC) | Cardiogenic Shock | 03/23 | 02/24 | | |
| Recruiting | N/A | 2224 | Europe | Fast discharge strategy | Medical University Innsbruck | Acute Myocardial Infarction (AMI) | 12/29 | 12/29 | | |
DOUBLE-CHOICE, NCT05036018: RanDOmized stUdy Comparing Both Latest Generation Self-Expanding Valves and a Minimalist approaCH vs. Standard Of Care In transCathEter Aortic Valve Implantation |
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| Active, not recruiting | N/A | 836 | Europe | ACURATE neo2, minimalist approach, CoreValve Evolut Pro and Pro+, Standard of care | Leipzig Heart Science gGmbH, Heart Center Leipzig - University Hospital | Aortic Valve Stenosis | 02/25 | 12/33 | | |
PROVE, NCT05539573: ACURATE neo2™ - Post Market Safety and Performance Surveillance in Aortic Stenosis |
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| Active, not recruiting | N/A | 1043 | Europe | Planned TAVI with the ACURATE neo2™ aortic bioprosthesis and ACURATE neo2™ transfemoral delivery system. | University of Leipzig, National University of Ireland, Galway | Aortic Stenosis | 04/25 | 04/25 | | |
| Recruiting | N/A | 650 | Europe, Canada, Japan, US, RoW | Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT) | Medtronic Cardiovascular | Moderate Aortic Valve Stenosis | 02/26 | 12/34 | | |
| Recruiting | N/A | 360 | Europe | Transcatheter tricuspid valve treatment (TTVT) | LMU Klinikum, Heart and Diabetes Center North Rhine-Westphalia, University Medical Center Mainz, Heart Center Leipzig - University Hospital, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), University of Leipzig | Heart Failure Attributable to Severe Tricuspid Regurgitation | 03/26 | 03/27 | | |
| Recruiting | N/A | 1200 | Europe, Canada, US | FlowTriever System, Anticoagulation Agents | Inari Medical | Pulmonary Embolism | 07/26 | 07/26 | | |
| Kääb, Stefan |
| Completed | 4 | 1105 | Europe | Iron, Saline, salin | Universitätsklinikum Hamburg-Eppendorf, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Charite University, Berlin, Germany | Systolic Heart Failure, Iron Deficiency | 05/24 | 05/24 | | |
CABA-HFPEF, NCT05508256: CAtheter-Based Ablation of Atrial Fibrillation Compared to Conventional Treatment in Patients With Heart Failure With Preserved Ejection Fraction |
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| Recruiting | 4 | 1548 | Europe | CE-marked Catheter Ablation | Charite University, Berlin, Germany, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Kompetenznetz Vorhofflimmern e.V. (AFNET), Boston Scientific Corporation | Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mildly Reduced Ejection Fraction | 07/26 | 07/27 | | |
ERKHA, NCT06091774: Clinical Study for the Investigation and Validation of a Therapy Procedure for the Adjustment of Risk Factors in Patients With Coronary Heart Disease by Means of Digital Therapy Control |
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| Recruiting | N/A | 1000 | Europe | CHD therapy through iATROS medical device | iATROS GmbH | Coronary Artery Disease, Cardiovascular Diseases, Coronary Heart Disease, Ischemic Heart Disease | 04/25 | 10/26 | | |
| Recruiting | N/A | 650 | Europe, Canada, Japan, US, RoW | Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT) | Medtronic Cardiovascular | Moderate Aortic Valve Stenosis | 02/26 | 12/34 | | |
