| Adams, David R |
NCT01675440: Safety & Efficacy Study of the Medtronic CoreValve® System-Treatment of Symptomatic Severe Aortic Stenosis With Significant Comorbidities in Extreme Risk Subjects Who Need Aortic Valve Replacement |
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| Active, not recruiting | N/A | 782 | US | Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI) | Medtronic Cardiovascular | Severe Aortic Stenosis | 12/16 | 01/26 | | |
SURTAVI, NCT01586910: Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (). |
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| Active, not recruiting | N/A | 1746 | Europe, Canada, US | Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI), Surgical Aortic Valve Replacement (SAVR), Medtronic CoreValve® Evolut R System Transcatheter Aortic Valve Implantation (TAVI) | Medtronic Cardiovascular | Severe Aortic Stenosis | 07/18 | 11/26 | | |
| Recruiting | N/A | 240 | Europe | Taste test | Ranvier Health Ltd | Depression | 12/24 | 02/25 | | |
| Completed | N/A | 251 | Europe | Neurological assessment and Blood sample | Centre Hospitalier Universitaire de Saint Etienne | Sensory Peripheral Neuropathy | 11/21 | 01/22 | | |
| Recruiting | N/A | 585 | US | NeoChord DS1000, Surgical Mitral Valve Repair | NeoChord | Mitral Valve Insufficiency | 07/22 | 07/27 | | |
| Active, not recruiting | N/A | 572 | Europe, Canada, US | TriClipTM Device | Abbott Medical Devices | Tricuspid Regurgitation | 11/22 | 04/29 | | |
| Active, not recruiting | N/A | 1312 | Europe, Canada, US | Model 400 aortic valve bioprosthesis | Medtronic Cardiac Surgery, Medtronic | Aortic Stenosis | 04/23 | 12/35 | | |
ICE-AFIB, NCT03732794: AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment |
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| Active, not recruiting | N/A | 150 | US | AtriCure CryoICE & AtriClip LAA Exclusion | AtriCure, Inc. | Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation | 06/24 | 12/26 | | |
| Recruiting | N/A | 15 | US | Intrepid™ TTVR System | Medtronic Cardiovascular | Tricuspid Regurgitation | 07/25 | 07/31 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Reddy, Vivek Y |
| Active, not recruiting | 3 | 514 | US | Argatroban, Eptifibatide, Placebo | Washington University School of Medicine, National Institute of Neurological Disorders and Stroke (NINDS) | Acute Ischemic Stroke | 12/23 | 04/25 | | |
| Terminated | 3 | 248 | US, RoW | Coherex WaveCrest® Left Atrial Appendage Occlusion System, Watchman® LAA Closure Device | Coherex Medical, Biosense Webster, Inc. | Stroke | 12/23 | 12/23 | | |
NCT05026866: A Donanemab (LY3002813) Prevention Study in Participants With Alzheimer's Disease (TRAILBLAZER-ALZ 3) |
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| Recruiting | 3 | 2600 | Japan, US | Donanemab, LY3002813, Placebo | Eli Lilly and Company | Alzheimer Disease | 11/27 | 11/27 | | |
| Recruiting | 2 | 300 | US | TS23 | Translational Sciences, Inc., University of Cincinnati, National Institute of Neurological Disorders and Stroke (NINDS), Medical University of South Carolina, University of Arizona | Ischemic Stroke | 07/27 | 12/27 | | |
| Terminated | N/A | 109 | US | MFAM | Vivek Reddy, Biosense Webster, Inc. | Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | 10/22 | 10/22 | | |
NCT04358029: Cardiac Arrhythmias In Patients With Coronavirus Disease (COVID-19) |
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| Completed | N/A | 4000 | US | | Vivek Reddy | COVID 19 Cardiac, COVID 16 Arrhythmia, COVID 19 Death | 04/23 | 04/23 | | |
ADVENT, NCT04612244: The FARAPULSE PIVOTAL Trial PFA System vs SOC Ablation for Paroxysmal Atrial Fibrillation |
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| Active, not recruiting | N/A | 900 | US | FARAPULSE Pulsed Field Ablation System, RadioFrequency and Cryoballoon Ablation | Farapulse, Inc. | Paroxysmal Atrial Fibrillation | 06/23 | 03/24 | | |
| Recruiting | N/A | 206 | US | cryoablation procedure | Adagio Medical | Sustained VT | 12/25 | 03/26 | | |
| Recruiting | N/A | 25 | US | Farawave PFA catheter | Vivek Reddy | Long-standing Persistent AF | 06/25 | 06/25 | | |
| Recruiting | N/A | 435 | Europe, Canada, US, RoW | Pulsed Field Ablation | Abbott Medical Devices | Atrial Arrhythmia, Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | 01/26 | 01/26 | | |
ULTRA-HFIB, NCT04182620: Ultrasound-Based Renal Sympathetic Denervation as Adjunctive Upstream Therapy During Atrial Fibrillation Ablation |
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| Active, not recruiting | N/A | 160 | US | renal denervation, Catheter ablation | Vivek Reddy | Atrial Fibrillation | 06/24 | 06/24 | | |
| Recruiting | N/A | 300 | US | OPTIMIZER® Integra CCM-D System (Treatment Arm) | Impulse Dynamics | Heart Failure, Heart Failure With Reduced Ejection Fraction, Implantable Defibrillator User, CCM Therapy, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy, Sudden Cardiac Arrest, Arrhythmias, Cardiac, Ventricular Tachycardia, Ventricular Fibrillation | 06/24 | 12/25 | | |
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study |
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| Recruiting | N/A | 400 | Europe, US, RoW | AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy | Ancora Heart, Inc. | Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy | 06/24 | 12/30 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
NCT05988411: ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation vs Control in Redo Ablation Patients |
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| Recruiting | N/A | 200 | US | Renal Denervation, Catheter Ablation | Vivek Reddy | Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | 12/24 | 12/24 | | |
VIRTUE, NCT06056557: Versatility of a Circular Multielectrode Catheter in the Individualized Recognition & Treatment of Atrial Fibrillation and Related Arrhythmias Using Pulsed Field Energy |
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| Enrolling by invitation | N/A | 150 | US | VARIPULSE™ catheter ablation | Vivek Reddy | Atrial Fibrillation, Paroxysmal or Persistent, Atrial Fibrillation and Flutter, Atrial Flutter Typical | 12/24 | 12/24 | | |
ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects With Persistent Atrial Fibrillation |
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| Active, not recruiting | N/A | 669 | Europe, Canada, US | Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System | Boston Scientific Corporation | Persistent Atrial Fibrillation | 03/25 | 03/25 | | |
MODULAR ATP, NCT04798768: Effectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia Pacing |
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| Active, not recruiting | N/A | 297 | Europe, Canada, US, RoW | mCRM Therapy System, Communication of S-ICD to Leadless Cardiac Pacemaker (LCP) | Boston Scientific Corporation | Tachycardia, Ventricular, Arrhythmia, Ventricular | 02/25 | 12/30 | | |
| Active, not recruiting | N/A | 481 | Europe, Canada, US, RoW | WATCHMAN LAAC Device Implant, Single Antiplatelet Therapy or No Therapy (Control) | Boston Scientific Corporation | Stroke | 12/25 | 12/25 | | |
INTERCEPT, NCT05723926: Carotid Implants for PreveNtion of STrokE ReCurrEnce From Large Vessel Occlusion in Atrial Fibrillation Patients Treated With Oral Anticoagulation |
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| Not yet recruiting | N/A | 2000 | NA | Vine Filter, Vine Embolic Protection System | Javelin Medical, Population Health Research Institute | Atrial Fibrillation, Oral Anticoagulation, Stroke, Implant | 12/28 | 10/30 | | |
| Whang, William |
| Recruiting | N/A | 25 | US | Farawave PFA catheter | Vivek Reddy | Long-standing Persistent AF | 06/25 | 06/25 | | |
| Recruiting | N/A | 300 | US | OPTIMIZER® Integra CCM-D System (Treatment Arm) | Impulse Dynamics | Heart Failure, Heart Failure With Reduced Ejection Fraction, Implantable Defibrillator User, CCM Therapy, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy, Sudden Cardiac Arrest, Arrhythmias, Cardiac, Ventricular Tachycardia, Ventricular Fibrillation | 06/24 | 12/25 | | |
| Koruth, Jacob |
NCT04831125: Conduction System Pacing International Registry (CONSPIRE) |
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| Recruiting | N/A | 1000 | Europe, US | Data collection | University of Chicago, Biotronik SE & Co. KG | Bradyarrhythmia, Heart Failure | 04/25 | 04/25 | | |
| Ellsworth, Betsy |
NCT04358029: Cardiac Arrhythmias In Patients With Coronavirus Disease (COVID-19) |
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| Completed | N/A | 4000 | US | | Vivek Reddy | COVID 19 Cardiac, COVID 16 Arrhythmia, COVID 19 Death | 04/23 | 04/23 | | |
POLARIS, NCT06099730: Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF |
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| Recruiting | N/A | 360 | US | Pulsed Field Ablation (PFA) | Massachusetts General Hospital | Atrial Fibrillation | 11/24 | 11/24 | | |
| Recruiting | N/A | 25 | US | Farawave PFA catheter | Vivek Reddy | Long-standing Persistent AF | 06/25 | 06/25 | | |
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study |
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| Recruiting | N/A | 400 | Europe, US, RoW | AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy | Ancora Heart, Inc. | Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy | 06/24 | 12/30 | | |
NCT05565599: An Early Feasibility Study Evaluating the Safety and Efficacy of the Laminar Left Atrial Appendage Closure System in Subjects With Non-Valvular Atrial Fibrillation |
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| Active, not recruiting | N/A | 45 | US | Left Atrial Appendage Closure | Laminar, Inc. | Non-valvular Atrial Fibrillation | 08/24 | 09/29 | | |
| Recruiting | N/A | 250 | US | HeartLight, Ablation | CardioFocus | Atrial Fibrillation | 10/24 | 10/26 | | |
NCT05988411: ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation vs Control in Redo Ablation Patients |
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| Recruiting | N/A | 200 | US | Renal Denervation, Catheter Ablation | Vivek Reddy | Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | 12/24 | 12/24 | | |
| Mitcham, Josephine |
TARGET-IBD, NCT03251118: A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease |
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| Recruiting | N/A | 15000 | US | | Target PharmaSolutions, Inc. | Inflammatory Bowel Diseases, Crohn's Disease, Ulcerative Colitis, Indeterminate Colitis | 07/25 | 07/25 | | |
| Recruiting | N/A | 4000 | Canada, US | None - Observational, Observational | American Gastroenterological Association, OpenBiome, University of California, San Diego, RX.Health Inc., University of Pennsylvania, University of Minnesota, Loyola University Chicago | Fecal Microbiota Transplantation, Clostridium Difficile Infection, Gut Microbiome | 08/27 | 08/27 | | |
