Braun, Thorsten |
| Recruiting | 3 | 124 | Europe | EPREX, Epoetin alfa | Groupe Francophone des Myelodysplasies | Myelodysplastic Syndromes | 05/22 | 05/24 | | |
| Recruiting | 3 | 550 | Europe, Canada, US, RoW | Tamibarotene, SY-1425, Placebo, Azacitidine | Syros Pharmaceuticals | Myelodysplastic Syndromes | 11/24 | 02/29 | | |
| Recruiting | 3 | 322 | Europe, Canada, US | Crenolanib, Crenolanib besylate, Cytarabine, Mitoxantrone, Placebo Oral Tablet, Fludarabine, Idarubicin, G-CSF | Arog Pharmaceuticals, Inc. | Relapsed/Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations | 10/24 | 10/24 | | |
HOVON 156 AML, NCT04027309 / 2018-000624-33: A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy |
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| Active, not recruiting | 3 | 777 | Europe, RoW | Gilteritinib, ASP2215, Midostaurin, Rydapt | Stichting Hemato-Oncologie voor Volwassenen Nederland, Deutsch-Österreichische Studiengruppe Akute Myeloische Leukämie (AMLSG), Astellas Pharma Global Development, Inc. | Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2 | 10/25 | 06/33 | | |
LOTIS 5, NCT04384484 / 2020-000241-14: Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma |
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| Active, not recruiting | 3 | 440 | Europe, Canada, Japan, US, RoW | Loncastuximab Tesirine, Zynlonta, ADCT-402, Rituximab, Gemcitabine, Oxaliplatin | ADC Therapeutics S.A., ADC Therapeutics SA | Relapsed Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma | 06/25 | 06/28 | | |
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| Recruiting | 2b | 102 | Europe, Canada, US, RoW | DPX-Survivac, maveropepimut-S, Pembrolizumab, MK-3475, Keytruda, CPA, Intermittent, low-dose cyclophosphamide, Procytox, Cytoxan | ImmunoVaccine Technologies, Inc. (IMV Inc.), Merck Sharp & Dohme LLC | Relapsed Diffuse Large B-cell Lymphoma, Refractory Diffuse Large B-cell Lymphoma | 10/24 | 04/25 | | |
PONAZA, NCT03895671: : A COMBINATION OF PONATINIB AND 5-AZACITIDINE IN CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE OR IN MYELOID BLAST CRISIS |
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| Recruiting | 2 | 40 | Europe | Ponatinib, Azacitidine | Versailles Hospital | CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE, CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS | 12/23 | 12/24 | | |
| Active, not recruiting | 2 | 95 | Europe, US | Tamibarotene, Venetoclax, Venclexta, Azacitidine, Vidaza | Syros Pharmaceuticals, Syros Pharmaceuticals, Inc. | Acute Myeloid Leukemia | 04/28 | 04/28 | | |
| Recruiting | 2 | 74 | Europe | Teclistamab, JNJ-64007957, Daratumumab, Lenalidomide | University Hospital, Lille, Janssen Pharmaceutica N.V., Belgium | Multiple Myeloma | 05/25 | 09/30 | | |
| Completed | 2 | 42 | Europe | CPX-351 | French Innovative Leukemia Organisation, Acute Leukemia French Association, French Intergroup of Myeloproliferative syndromes | Acute Myeloid Leukemia, Myeloproliferative Syndrome | 10/23 | 12/23 | | |
AVENHIR, NCT05768711: Azacitidine Combined With Venetoclax in Patients With Higher-risk Chronic Myelomonocytic Leukemia |
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| Recruiting | 2 | 44 | Europe | Venetoclax, ABT-199 | Groupe Francophone des Myelodysplasies, AbbVie | Chronic Myeloid Leukemia | 02/26 | 10/28 | | |
| Recruiting | 2 | 50 | Europe | Gemtuzumab ozogamicine - Cytarabine - Gilteritinib, Mylotarg - Aracytine - Xospata | Centre Antoine Lacassagne, Acute Leukemia French Association | AML | 03/27 | 03/27 | | |
ALFA2101, NCT05260528: CPX-351 vs Intensive Chemotherapy in Patients With de Novo Intermediate or Adverse Risk AML Stratified by Genomics |
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| Recruiting | 2 | 210 | Europe | Cytarabine and Idarubicin, CPX-315 | Centre Hospitalier Universitaire de Nice, Jazz Pharmaceuticals, Acute Leukemia French Association | Acute Myeloid Leukemia | 10/27 | 10/27 | | |
ACTIW, NCT02767063: Therapies in Combination or Sequentially With Tyrosine Kinase Inhibitors (TKIs) in Chronic Phase Chronic Myelogenous Leukemia Patients in CCR |
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| Recruiting | 1/2 | 100 | Europe | Pioglitazone, Avelumab | Versailles Hospital | Leukemia, Myeloid, Chronic-Phase | 11/22 | 06/23 | | |
SALMA, NCT05580861: Sulfasalazine in AML Treated by Intensive Chemotherapy: Elderly Patients-first Line Treatment |
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| Recruiting | 1/2 | 64 | Europe | Sulfasalazine | Assistance Publique - Hôpitaux de Paris | Acute Myeloid Leukemia | 11/25 | 12/26 | | |
NCT05782127: Oral Azacitidine Combined with Venetoclax in Previously Untreated Higher-risk Myelodysplastic Syndromes |
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| Recruiting | 1/2 | 36 | Europe | Onureg + Venetoclax, CC-486 + ABT-199 | Groupe Francophone des Myelodysplasies, Bristol-Myers Squibb, AbbVie | Untreated Myelodysplastic Syndrome | 11/25 | 11/28 | | |
NCT02629692 / 2016-001754-18: Safety and Anti-leukemic Activity of Vodobatinib (K0706) for Treatment of Ph+ CML Resistant/Intolerant to ≥3 Prior CML Therapies |
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| Active, not recruiting | 1/2 | 122 | Europe, US, RoW | Vodobatinib (K0706) capsules | Sun Pharma Advanced Research Company Limited | Healthy (For Part A), Chronic Myeloid Leukemia (for Part B and C) | 08/26 | 08/26 | | |
NCT05181735: Study Evaluating Combination of Luspatercept in LR-MDS Without RS Having Failed or Being Ineligible to ESA |
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| Recruiting | 1/2 | 150 | Europe | Luspatercept Injection [Reblozyl], ACE-536, Eprex, Epoietin alfa | Groupe Francophone des Myelodysplasies, Celgene | MDS, Myelodysplastic Syndromes | 05/27 | 11/27 | | |
ALFAPPP, NCT04777916: Prospective Non-interventional Study of Adult Patients With Acute Myeloid Leukemia (AML) |
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| Recruiting | N/A | 2500 | Europe | | Acute Leukemia French Association | Acute Myeloid Leukemia (AML) | 04/32 | 04/46 | | |
| Recruiting | N/A | 3000 | Europe | Biobanking | Assistance Publique - Hôpitaux de Paris | Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, High-risk Myelodysplastic Syndrome, Secondary Myelofibrosis in Myeloproliferative Disease, Myeloproliferative Neoplasm, Unclassifiable | 03/42 | 03/42 | | |
DYNHAEMICS, NCT05304156: Single-cell Dynamic Profiling in Adults With Newly Diagnosed Acute Myeloid Leukemia Treated With Intensive Chemotherapy. A THEMA Study" |
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| Recruiting | N/A | 200 | Europe | Biobanking blood and bone marrow specimens | Assistance Publique - Hôpitaux de Paris | Acute Myeloid Leukemia | 04/26 | 05/26 | | |