University Health Network - Toronto General Hospital
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 59 Trials 
125 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Dzavik, Vladimir
SEMPATICO, NCT04615871: Semaglutide to Reduce Myocardial Injury in PATIents With COVID-19

Recruiting
2
400
Europe, Canada, RoW
semaglutide, Ozempic
Vladimír Džavík, Unity Health Toronto, Canadian Institutes of Health Research (CIHR), University of Toronto
Covid19, Myocardial Injury
03/22
03/22
COSIRA-II, NCT05102019: Efficacy of the COronary SInus Reducer in Patients with Refractory Angina II

Recruiting
N/A
380
Canada, US
Arm 1: treatment with Neovasc Reducer, Arm 2 (control): Implantation procedure with no device implanted, Arm 3 (unblinded, non-randomized): Single arm registry
Neovasc Inc., Shockwave Medical, Inc.
Refractory Angina
06/25
12/28
Allard, Johane
NCT02970877: Stool Transplantation for Treatment of Insulin Resistance in Morbidly Obese Patients

Active, not recruiting
2
48
Canada
Fecal filtrate from 150 g stool from healthy lean donors, Intestinal microbiota from healthy lean donors, Fecal filtrate from 150 g of the recipient's own stool, Autologous intestinal microbiota
Johane Allard, Canadian Institutes of Health Research (CIHR), MOUNT SINAI HOSPITAL, University of Toronto
Obesity, Morbid, Insulin Resistance
06/22
11/22
NCT01856465: Intestinal Microbiota and NAFLD Pre and Post Bariatric Surgery

Active, not recruiting
N/A
120
Canada
Johane Allard, Canadian Institutes of Health Research (CIHR)
Morbid Obesity, Non-alcoholic Fatty Liver Disease
06/22
08/23
NCT03723486: Bariatric Surgery: Microbiome & Diabetes

Active, not recruiting
N/A
120
Canada
University Health Network, Toronto, Canadian Institutes of Health Research (CIHR)
Obesity
06/22
12/23
NCT04067245: Use of Tetrasodium EDTA Catheter Lock Solution for Patients on HTPN

Recruiting
N/A
20
Canada
Tetrasodium EDTA catheter lock solution
University Health Network, Toronto
Catheter Complications
12/24
03/25
NCT02298439: Fatty Liver Patient Registry

Recruiting
N/A
100
Canada
University Health Network, Toronto
Non-Alcoholic Fatty Liver Disease
06/26
06/26
HTPN, NCT02299466: Registry for Patients Receiving Intravenous Nutrition at Home

Recruiting
N/A
1000
Canada
University Health Network, Toronto, Canadian Nutrition Society, Baxter Healthcare Corporation, Ontario Medical Supply
Parenteral Nutrition, Home
12/29
12/29
Katznelson, Rita
NCT04500626: Hyperbaric Versus Normobaric Oxygen Therapy for COVID-19 Patients

Recruiting
2/3
234
Canada
Oxygen
Ottawa Hospital Research Institute, Climate Foundation
Covid19
08/22
08/22
RECLAIM - HBOT, NCT06452095: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hyperbaric Oxygen Therapy for the Treatment of Post COVID Condition

Not yet recruiting
2/3
120
NA
Hyperbaric Oxygen therapy
University Health Network, Toronto
Long COVID, Post COVID Condition, Post Acute Sequelae of COVID-19
12/28
12/28
NCT03861026: Cerebral Oximetry to Reduce Organ Dysfunction After Non-cardiac Surgery

Completed
N/A
101
Canada
Bilateral NIRS (Masimo, O3TM Regional Oximetry)
University Health Network, Toronto
Cerebral Desaturation, Surgery
01/23
06/23
Keshavjee, Shaf
ULTIMATE, NCT04832789: Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO

Not yet recruiting
N/A
72
Canada, US
Venovenous ECMO
University of Toronto, University Health Network, Toronto
ARDS
06/23
12/23
INTERLUNG, NCT02812290: Diagnostic and Therapeutic Applications of Microarrays in Lung Transplantation

Recruiting
N/A
700
Europe, Canada, US, RoW
Lung transplant biopsy bites.
University of Alberta
Lung Transplant Rejection
11/25
06/26
NCT05837663: Trifecta-Lung cfDNA-MMDx Study

Recruiting
N/A
600
Europe, Canada, US, RoW
University of Alberta, Natera, Inc., One Lambda
Lung Transplantation
11/26
12/27
NCT05898776: 10°C Vs 4°C Lung Preservation RCT

Recruiting
N/A
300
Europe, Canada, US, RoW
Lung transplantation after 10°C donor lung preservation, Lung transplantation after standard ice cooler donor lung preservation
University Health Network, Toronto, Medical University of Vienna, Vanderbilt University, Puerta de Hierro University Hospital, University of California, San Francisco, Centre Hospitalier Universitaire Vaudois, Mayo Clinic, St Vincent's Hospital, Sydney
Lung Transplant, Organ Preservation
07/25
07/26
NCT05581745: A2 to O Lung Transplants

Recruiting
N/A
10
Canada
Blood group A2 donor to blood group O recipient lung transplant surgery
University Health Network, Toronto
Lung Transplant, ABO Incompatibility
12/26
12/33
ALAMO, NCT05050955: AlloSure Lung Assessment and Metagenomics Outcomes Study

Recruiting
N/A
500
Canada, US
CareDx
Lung Transplant Infection, Lung Transplant; Complications, Lung Transplant Failure and Rejection
12/28
12/28
NCT03265379: Improving Quality of Life for Patients With Breast Cancer Invading the Chest Wall: A Prospective Registry For Patients Undergoing Full Thickness Chest Wall Resection

Recruiting
N/A
104
Canada
FACT-B and Brief Pain Inventory
University Health Network, Toronto
Breast Cancer
08/30
08/30
Yeo, Erik
COBRRA, NCT03266783: Comparison of Bleeding Risk Between Rivaroxaban and Apixaban for the Treatment of Acute Venous Thromboembolism

Recruiting
4
2760
Europe, Canada, RoW
Apixaban, Eliquis, Rivaroxaban, Xarelto
Ottawa Hospital Research Institute, Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network, Canadian Institutes of Health Research (CIHR)
Venous Thromboembolism
12/24
12/24
API-CAT, NCT03692065 / 2017-003342-25: STUDY for APIxaban Cancer Associated Thrombosis

Completed
3
1766
Europe, Canada
Apixaban 5 MG, Apixaban 2.5 MG
Assistance Publique - Hôpitaux de Paris, Bristol-Myers Squibb
Cancer-associated Thrombosis
09/24
10/24
SAVER, NCT04319627 / 2021-001559-15: Statins for Venous Event Reduction in Patients With Venous Thromboembolism

Recruiting
3
2700
Europe, Canada
Rosuvastatin Calcium, Rosuvastatin, Placebo Oral Tablet, Placebo
Ottawa Hospital Research Institute, The Canadian Institutes of Health Research (CIHR)
Venous Thromboembolism, Blood Clot, Post Thrombotic Syndrome
01/26
01/27
WAVe, NCT03297359: Study - Weight Adjusted Dalteparin for Patients Over 90 kg With Acute Cancer Associated Venous Thromboembolism

Terminated
2
92
Canada
Dalteparin
Ottawa Hospital Research Institute, Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network
Cancer, Venous Thromboembolism, Obesity
11/23
11/23
MVTEP2/SOME2, NCT04304651: Screening for Occult Malignancy in Patients with Unprovoked Venous Thromboembolism

Recruiting
N/A
1276
Europe, Canada
Limited cancer screening, Limited cancer screening + FDG PET/CT
University Hospital, Brest, Ministry of Health, France, Canadian Institutes of Health Research (CIHR), Ottawa Hospital Research Institute
Embolism and Thrombosis
09/26
09/30
Pierre, Andrew
STABLE-MATES, NCT02468024: JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer

Recruiting
3
272
Europe, Canada, US, RoW
Lung Surgery, SR, Radiation therapy, SAbR
University of Texas Southwestern Medical Center
Non-Small Cell Lung Cancer
12/28
12/28
Friedrich, Jan
MAGNAM, NCT05287191: Trial, Magnesium Versus Amiodarone in Atrial Fibrillation in Critical Care

Recruiting
3
200
Canada
Magnesium sulfate and then Digoxin, Amiodarone
Sunnybrook Health Sciences Centre, Sunnybrook Research Institute
Atrial Fibrillation New Onset
10/25
04/26
FISSH, NCT03677102: Fluids in Septic Shock

Recruiting
2/3
1096
Canada, RoW
higher chloride crystalloid, lower chloride crystalloid
McMaster University, The Physicians' Services Incorporated Foundation, Canadian Institutes of Health Research (CIHR)
Sepsis, Septic Shock
11/25
03/26
InCURS, NCT04176094: Intensive Care Unit Resident Scheduling Trial

Recruiting
N/A
20
Canada
16h overnight duty, 24h overnight duty, Handover training
The Hospital for Sick Children, Sunnybrook Health Sciences Centre
Patient Safety, Well-being, Education
03/26
06/26
ULTIMATE, NCT04832789: Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO

Not yet recruiting
N/A
72
Canada, US
Venovenous ECMO
University of Toronto, University Health Network, Toronto
ARDS
06/23
12/23
Lok, Charmaine
PHOSPHATE, NCT03573089: Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease

Recruiting
N/A
3600
Europe, Canada, RoW
Liberal phosphate target, Intensive phosphate target
The University of Queensland, National Health and Medical Research Council, Australia, Applied Health Research Centre, Cambridge University Hospitals NHS Foundation Trust, University of Otago
Kidney Failure, Chronic, Hyperphosphatemia
12/27
12/28
NCT04932148: INCremental Dialysis to Improve Health Outcomes in People Starting Haemodialysis (INCH-HD)

Recruiting
N/A
372
Canada, RoW
Incremental HD, Conventional HD
The University of Queensland, Medical Research Future Fund, Queensland Health, Canadian Institutes of Health Research (CIHR)
Kidney Failure
08/26
08/26
McAlpine, David
MAGNAM, NCT05287191: Trial, Magnesium Versus Amiodarone in Atrial Fibrillation in Critical Care

Recruiting
3
200
Canada
Magnesium sulfate and then Digoxin, Amiodarone
Sunnybrook Health Sciences Centre, Sunnybrook Research Institute
Atrial Fibrillation New Onset
10/25
04/26
Fan, Eddy
MAGNAM, NCT05287191: Trial, Magnesium Versus Amiodarone in Atrial Fibrillation in Critical Care

Recruiting
3
200
Canada
Magnesium sulfate and then Digoxin, Amiodarone
Sunnybrook Health Sciences Centre, Sunnybrook Research Institute
Atrial Fibrillation New Onset
10/25
04/26
A-FREE ECMO, NCT04273607: Anticoagulation-free VV ECMO for Acute Respiratory Failure

Recruiting
2/3
40
Canada
Subcutaneous Heparin, Enoxaparin or unfractionated heparin
Damian Ratano, PSI Foundation, Toronto, Ontario
Extracorporeal Membrane Oxygenation Complication
12/23
06/24
TEGMO, NCT04268940: Thrombo-Elastography Guided Management of ECMO

Active, not recruiting
N/A
61
Canada
Thromboelastography
Damian Ratano, The PSI Foundation, Ontario
Extracorporeal Circulation of Blood; Thrombocytopenia
08/21
09/21
ULTIMATE, NCT04832789: Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO

Not yet recruiting
N/A
72
Canada, US
Venovenous ECMO
University of Toronto, University Health Network, Toronto
ARDS
06/23
12/23
NCT05486559: The ECMO-Free Trial

Recruiting
N/A
60
Canada, US
ECMO-free protocol, Usual Care
Vanderbilt University Medical Center
Extracorporeal Membrane Oxygenation Complication
11/25
12/25
PRACTICAL, NCT05440851: Platform of Randomized Adaptive Clinical Trials in Critical Illness

Recruiting
N/A
6250
Canada
Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL), Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS), Early Cohort corticosteroid dose, Extended Cohort corticosteroid dose, Usual care without routine corticosteroids, Usual care without extending corticosteroids, Usual care with fludrocortisone, Usual care without fludrocortisone, 4 mL of nebulized 0.9% saline minutes every 6 hours over 30 minutes every 6 hours., 40 mg of nebulized furosemide in 4 mL of saline nebulized over 30 minutes every 6 hours, PEEP-20, PEEP-AOP, PEEP-10
University Health Network, Toronto, University Health Network, Toronto
Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
03/27
03/27
AiCLOSE, NCT05196074: Airway Closure During Extracorporeal Membrane Oxygenation: The Study

Recruiting
N/A
299
Canada
Acute hypoxemic respiratory failure patients on VV-ECMO
Lorenzo delSorbo, Unity Health Toronto
Acute Hypoxemic Respiratory Failure
04/25
04/26
ECMO-Rehab, NCT05003609: Early Rehabilitation in Patients on Extracorporeal Membrane Oxygenation

Active, not recruiting
N/A
100
Canada, RoW
Early Rehabilitation
Australian and New Zealand Intensive Care Research Centre, Monash University, National Health and Medical Research Council, Australia
Extracorporeal Membrane Oxygenation Complication
05/25
05/25
Hahn, Margaret
NCT03741478: Intranasal Insulin and Olanzapine Study in Healthy Volunteers

Recruiting
1
64
Canada
OLANZapine 2.5 MG, Mylan-Olanzapine, Placebo, Olanzapine Placebo, Insulin Lispro 100 UNT/ML, Intranasal Insulin, Saline
Centre for Addiction and Mental Health, University Health Network, Toronto
Healthy Controls
07/24
07/24
NCT03414151: Gut Microbiome in AP Naive

Recruiting
N/A
25
Canada
Observation
Centre for Addiction and Mental Health, McMaster University
Psychotic Disorder, Schizophrenia
03/22
03/22
NCT02808533: Topiramate and Schizophrenia: Effects on Weight and Psychopathology

Recruiting
N/A
50
Canada
Topiramate, Topamax, Placebo
Centre for Addiction and Mental Health, Ontario Ministry of Health and Long Term Care
Schizophrenia, Schizoaffective Disorder
07/24
07/24
Sema, NCT05333003: glutide in Comorbid Schizophrenia Spectrum Disorder and Obesity

Recruiting
N/A
92
Canada
Semaglutide, Placebo
Centre for Addiction and Mental Health
Schizophrenia Spectrum Disorders
08/25
08/25
Hirschfield, Gideon
NCT04950127 / 2021-000007-21: Global Linerixibat Itch Study of Efficacy and Safety in Primary Biliary Cholangitis (PBC) (GLISTEN)

Active, not recruiting
3
238
Europe, Canada, Japan, US, RoW
Linerixibat, Placebo
GlaxoSmithKline
Pruritus
10/24
01/25
LLSAT, NCT04167358 / 2019-003158-10: Linerixibat Long-term Safety, and Tolerability Study

Recruiting
3
251
Europe, Canada, Japan, US, RoW
Linerixibat
GlaxoSmithKline, GlaxoSmithKline LLC, GlaxoSmithKline Research & Development Limited
Cholestasis
02/27
02/27
PACIFIC, NCT05525520 / 2021-002526-25: Study to Evaluate EP547 in Subjects With Cholestatic Pruritus Due to Primary Biliary Cholangitis or Primary Sclerosing Cholangitis

Completed
2
62
Europe, Canada, US, RoW
EP547, Placebo
Escient Pharmaceuticals, Inc, Escient Pharmaceuticals, Inc.
Pruritus
07/24
09/24
VISTAS, NCT04663308 / 2020-003027-41: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

Recruiting
2
200
Europe, Canada, US, RoW
Volixibat, SHP626, Placebo
Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc.
Primary Sclerosing Cholangitis
09/25
12/25
BELief, NCT06381453: Belimumab in Autoimmune Hepatitis

Recruiting
2
48
Canada
Belimumab Auto-Injector [Benlysta], Benlysta
University Health Network, Toronto, GlaxoSmithKline
Autoimmune Hepatitis
04/28
04/29
WIND-PSC, NCT06297993: Global Prospective, Observational Cohort of Adult Patients with Primary Sclerosing Cholangitis ( Study)

Recruiting
N/A
2000
Canada, US
PSC Partners Seeking a Cure
PSC
01/29
01/31
Patel, Chirag
NAVIGATE, NCT04365868 / 2019-001983-31: Study Evaluating the Efficacy and Safety of Belapectin for the Prevention of Esophageal Varices in NASH Cirrhosis

Active, not recruiting
2b
357
Europe, Canada, US, RoW
belapectin, GR-MD-02, galactoarabino rhamnogalacturonate, Placebo
Galectin Therapeutics Inc., Galectin Therapeutics Inc
Prevention of Esophageal Varices, NASH - Nonalcoholic Steatohepatitis, Cirrhosis
12/24
12/24
VISTAS, NCT04663308 / 2020-003027-41: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

Recruiting
2
200
Europe, Canada, US, RoW
Volixibat, SHP626, Placebo
Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc.
Primary Sclerosing Cholangitis
09/25
12/25
NCT05305365: Study Assessing QBS72S for Treating Brain Metastases

Recruiting
2
40
US
QBS72S, QBS10072S
Melanie Hayden Gephart, Quadriga Biosciences, Inc.
Brain Metastases, Breast Cancer, Lung Cancer, Leptomeningeal Disease, LMD
02/25
08/26
Goligher, Ewan C
SAVE-ICU, NCT04415060: SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival

Recruiting
3
800
Canada
Isoflurane Inhalant Product, Sevoflurane inhalant product
Sunnybrook Health Sciences Centre
Covid19, Hypoxic Respiratory Failure
03/26
06/27
NCT03612583: Lung and Diaphragm-Protective Ventilation by Means of Assessing Respiratory Work

Completed
1
23
Canada
Lung- and Diaphragm-Protective Ventilation, LDPV
University Health Network, Toronto
Diaphragm Injury, Lung Injury, Respiratory Insufficiency, Mechanical Ventilation Complication
11/22
11/22
BEARDS, NCT03447288: Incidence of Dyssynchronies in Early ARDS

Recruiting
N/A
300
Europe, Canada, RoW
Unity Health Toronto
ARDS, Acute Hypoxemic Respiratory Failure
08/22
08/22
PNEUMA, NCT04524585: Partial Neuromuscular Blockade in Acute Respiratory Distress Syndrome

Terminated
N/A
4
Canada
Neuromuscular blockade
University Health Network, Toronto
Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Neuromuscular Blockade
03/23
03/23
ULTIMATE, NCT04832789: Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO

Not yet recruiting
N/A
72
Canada, US
Venovenous ECMO
University of Toronto, University Health Network, Toronto
ARDS
06/23
12/23
RADAR, NCT04103996: Incidence, Risk Factors and Outcomes of Diaphragm Dysfunction After Lung Transplantation

Completed
N/A
15
Canada
Ultrasound, Respiratory function measurements
University Health Network, Toronto
Diaphragm Injury, Lung Transplant; Complications, Mechanical, Respiratory Failure, Mechanical Ventilation Complication
12/21
12/21
BATMAN, NCT06142773: Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans

Recruiting
N/A
10
Canada
Tidal Volume set on ventilator
University Health Network, Toronto
Ventilation Therapy; Complications
11/24
12/24
STIMULUS, NCT05465083: Feasibility of Transvenous Phrenic Nerve Stimulation for Diaphragm Protection in Acute Respiratory Failure

Completed
N/A
20
Canada
Lungpacer AeroPace Protect System
University Health Network, Toronto, Lungpacer Medical Inc.
Acute Hypoxemic Respiratory Failure, Diaphragm Injury, Lung Injury
10/23
11/23
RESPIRE, NCT05857774: Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes

Recruiting
N/A
230
Canada
Sonographic measurements, Physiological measurements, Biological measurements
University Health Network, Toronto
Mechanical Ventilation Complication, Diaphragm Injury, Lung Injury, Respiratory Insufficiency, Abdominal Muscle Strained
12/25
06/26
PRACTICAL, NCT05440851: Platform of Randomized Adaptive Clinical Trials in Critical Illness

Recruiting
N/A
6250
Canada
Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL), Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS), Early Cohort corticosteroid dose, Extended Cohort corticosteroid dose, Usual care without routine corticosteroids, Usual care without extending corticosteroids, Usual care with fludrocortisone, Usual care without fludrocortisone, 4 mL of nebulized 0.9% saline minutes every 6 hours over 30 minutes every 6 hours., 40 mg of nebulized furosemide in 4 mL of saline nebulized over 30 minutes every 6 hours, PEEP-20, PEEP-AOP, PEEP-10
University Health Network, Toronto, University Health Network, Toronto
Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
03/27
03/27
AiCLOSE, NCT05196074: Airway Closure During Extracorporeal Membrane Oxygenation: The Study

Recruiting
N/A
299
Canada
Acute hypoxemic respiratory failure patients on VV-ECMO
Lorenzo delSorbo, Unity Health Toronto
Acute Hypoxemic Respiratory Failure
04/25
04/26
CAVIARDS, NCT03963622: Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)

Recruiting
N/A
740
Europe, Canada, US, RoW
Respiratory Mechanics, Standard Ventilation Strategy
Unity Health Toronto, Canadian Institutes of Health Research (CIHR), University of Toronto, Applied Health Research Centre
ARDS
11/25
03/26
DIASPORA, NCT03667027: Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant

Recruiting
N/A
40
Canada
Respiratory support
University Health Network, Toronto, The Hospital for Sick Children
Diaphragm Injury, Respiratory Failure, Mechanical Ventilation Complication
08/25
12/25
Throughflow, NCT05642832: Feasibility of Reducing Respiratory Drive Using the Through-flow System

Recruiting
N/A
15
Canada
Throughflow titration phase
University Health Network, Toronto, Unity Health Toronto
Respiratory Insufficiency, Diaphragm Injury, Lung Injury
06/25
08/25
Ankoma-Sey, Victor
NATiV3, NCT04849728: A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( )

Recruiting
3
1000
Europe, Canada, US, RoW
IVA337, Lanifibranor, Placebo
Inventiva Pharma
NASH - Nonalcoholic Steatohepatitis
09/25
09/26
PACIFIC, NCT05525520 / 2021-002526-25: Study to Evaluate EP547 in Subjects With Cholestatic Pruritus Due to Primary Biliary Cholangitis or Primary Sclerosing Cholangitis

Completed
2
62
Europe, Canada, US, RoW
EP547, Placebo
Escient Pharmaceuticals, Inc, Escient Pharmaceuticals, Inc.
Pruritus
07/24
09/24
VISTAS, NCT04663308 / 2020-003027-41: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

Recruiting
2
200
Europe, Canada, US, RoW
Volixibat, SHP626, Placebo
Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc.
Primary Sclerosing Cholangitis
09/25
12/25
HORIZON, NCT05583344 / 2022-002538-14: Phase 2b Study of GSK4532990 in Adults With NASH

Active, not recruiting
2
271
Europe, Canada, Japan, US, RoW
GSK4532990, Placebo
GlaxoSmithKline, GlaxoSmithKline Research & Development Limited
Nonalcoholic Fatty Liver Disease, Non-alcoholic Fatty Liver Disease
12/25
03/26
Cypel, Marcelo
NCI-2018-01456, NCT03599752: Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases

Active, not recruiting
2
40
Canada, US
Chemotherapy, Chemo, Chemotherapy (NOS), Chemotherapy, Cancer, General, Metastasectomy
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Colorectal Adenocarcinoma, Colorectal Carcinoma Metastatic in the Lung, Stage IV Colorectal Cancer AJCC v8, Stage IVA Colorectal Cancer AJCC v8, Stage IVB Colorectal Cancer AJCC v8, Stage IVC Colorectal Cancer AJCC v8
01/30
01/30
NCT03112044: Lung Transplant HCV, Pilot Study

Active, not recruiting
1
26
Canada
Sofosbuvir-velpatasvir (400 mg/100 mg), Epclusa, Ex Vivo Lung Perfusion (EVLP), Normothermic EVLP
University Health Network, Toronto, Gilead Sciences
Lung Transplant Infection, Hepatitis C
01/20
12/24
NCT02811523: In Vivo Lung Perfusion for Pulmonary Metastases of Sarcoma

Recruiting
1
17
Canada
Doxorubicin
University Health Network, Toronto
Bone Sarcoma, Soft Tissue Sarcoma, Pulmonary Metastases
02/25
02/25
NCT05611034: In Vivo Lung Perfusion (IVLP) for Colorectal Cancer Metastatic to Lung

Recruiting
1
10
Canada
Oxaliplatin
University Health Network, Toronto
Lung Metastases, Colorectal Cancer Metastatic, Colorectal Cancer
01/27
01/32
NCT04616365: Planned Semi-Elective Lung Tx Study

Completed
N/A
70
Europe, Canada
Semi-Elective Lung Transplantation
University Health Network, Toronto
Lung Transplantation
04/22
04/23
ULTIMATE, NCT04832789: Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO

Not yet recruiting
N/A
72
Canada, US
Venovenous ECMO
University of Toronto, University Health Network, Toronto
ARDS
06/23
12/23
REVOLUTION, NCT06615492: Routine vs On-demand ECMO for Lung Transplantation

Not yet recruiting
N/A
218
Canada
Routine ECMO, On-demand ECMO
Centre hospitalier de l'Université de Montréal (CHUM)
Respiratory Failure, Interstitial Lung Disease (ILD), Pulmonary Fibrosis, COPD (Chronic Obstructive Pulmonary Disease)
10/28
12/28
NCT05898776: 10°C Vs 4°C Lung Preservation RCT

Recruiting
N/A
300
Europe, Canada, US, RoW
Lung transplantation after 10°C donor lung preservation, Lung transplantation after standard ice cooler donor lung preservation
University Health Network, Toronto, Medical University of Vienna, Vanderbilt University, Puerta de Hierro University Hospital, University of California, San Francisco, Centre Hospitalier Universitaire Vaudois, Mayo Clinic, St Vincent's Hospital, Sydney
Lung Transplant, Organ Preservation
07/25
07/26
Wong, Florence
NCT02600117: Use of TDF in Patients With Inactive Chronic Hepatitis B Infection

Completed
3
50
Canada
Tenofovir disoproxil fumarate, Viread
University Health Network, Toronto, Gilead Sciences
Hepatitis B, Chronic
02/23
02/23
PRECIOSA, NCT03451292 / 2016-001789-28: Effects of Long-Term Administration of Human Albumin in Subjects With Decompensated Cirrhosis and Ascites

Completed
3
410
Europe, Canada, US, RoW
Albutein 20% Injectable Solution, Standard medical treatment
Grifols Therapeutics LLC, Instituto Grifols, S.A.
Decompensated Cirrhosis and Ascites
05/24
05/24
NATiV3, NCT04849728: A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( )

Recruiting
3
1000
Europe, Canada, US, RoW
IVA337, Lanifibranor, Placebo
Inventiva Pharma
NASH - Nonalcoholic Steatohepatitis
09/25
09/26
NCT05111327: Skills Learning and Self-confidence in Learning in High-fidelity Simulation

Recruiting
N/A
100
RoW
Structured guideline
Tung Wah College
Problem-solving, Clinical Reasoning, Satisfaction
06/22
03/23
POSEIDON, NCT03973866: Alfapump® System in the Treatment of Refractory or Recurrent Ascites ( Study)

Active, not recruiting
N/A
110
Canada, US
Alfapump
Sequana Medical N.V.
Ascites
03/24
06/24
Campbell, Eileen
SAVE-ICU, NCT04415060: SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival

Recruiting
3
800
Canada
Isoflurane Inhalant Product, Sevoflurane inhalant product
Sunnybrook Health Sciences Centre
Covid19, Hypoxic Respiratory Failure
03/26
06/27
FISSH, NCT03677102: Fluids in Septic Shock

Recruiting
2/3
1096
Canada, RoW
higher chloride crystalloid, lower chloride crystalloid
McMaster University, The Physicians' Services Incorporated Foundation, Canadian Institutes of Health Research (CIHR)
Sepsis, Septic Shock
11/25
03/26
AX-COVID, NCT04748757: Annexin A5 in Patients With Severe COVID-19 Disease

Completed
2
18
Canada
recombinant human annexin A5, SY-005, Placebo
Lawson Health Research Institute, Ontario Ministry of Colleges and Universities, London Health Sciences Foundation
Coronavirus Infection, Sepsis
04/22
12/22
Campbell, Kathryn
SARO.20.002, NCT05011305: Saroglitazar Magnesium for the Treatment of Nonalcoholic Steatohepatitis with Fibrosis

Active, not recruiting
2
180
US, RoW
Saroglitazar Magnesium 2 mg, Investigational Product, Saroglitazar Magnesium 4 mg, Placebo, Comparator Agent
Zydus Therapeutics Inc.
Nonalcoholic Steatohepatitis, Fibrosis
07/25
07/25
VISTAS, NCT04663308 / 2020-003027-41: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

Recruiting
2
200
Europe, Canada, US, RoW
Volixibat, SHP626, Placebo
Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc.
Primary Sclerosing Cholangitis
09/25
12/25
NCT04884815 / 2020-005266-34: Study of UX701 Gene Transfer for the Treatment of Wilson Disease

Active, not recruiting
1/2
78
Europe, Canada, US
UX701, Placebo
Ultragenyx Pharmaceutical Inc, Ultragenyx Pharmaceutical Inc.
Wilson Disease
08/26
11/31
Dash, Satya
NCT03741478: Intranasal Insulin and Olanzapine Study in Healthy Volunteers

Recruiting
1
64
Canada
OLANZapine 2.5 MG, Mylan-Olanzapine, Placebo, Olanzapine Placebo, Insulin Lispro 100 UNT/ML, Intranasal Insulin, Saline
Centre for Addiction and Mental Health, University Health Network, Toronto
Healthy Controls
07/24
07/24
Ouzounian, Maral
NCT03035643: DARTS I Feasibility Study

Completed
N/A
40
Canada
AMDS
Ascyrus Medical LLC., Artivion Inc.
Aortic Dissection, Intramural Hematoma
08/19
03/24
TITAN:COMMENCE, NCT02860364: Comparing Hypothermic Temperatures During Hemiarch Surgery

Recruiting
N/A
282
Canada, US
Hypothermic circulatory arrest
Ottawa Heart Institute Research Corporation
Thoracic Aortic Disease
02/25
09/25
TITAN:SvS, NCT03536312: Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance

Recruiting
N/A
610
Canada, US
Thoracic Aortic Surgery
Ottawa Heart Institute Research Corporation, University of Calgary
Ascending Aortic Aneurysm Enlargement, Ascending Aorta Aneurysm
05/25
05/26
Syeda, Ambreen
REFINE-ICD, NCT00673842: Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction

Active, not recruiting
3
700
Europe, Canada, US, RoW
Implantable Cardioverter Defibrillator + Usual Care, Implantable Cardioverter Defibrillator, ICD, Usual care, Standard medical therapy alone
University of Calgary, Canadian Institutes of Health Research (CIHR), Alberta Innovation and Science, Medtronic, GE Healthcare, Cardiac Arrhythmia Network of Canada, Accelerating Clinical Trials Consortium
Myocardial Infarction, Sudden Death
12/24
12/24
ASAP, NCT05257629: Aggressive Smoking Cessation Trial

Recruiting
3
798
Canada
Combination Therapy Arm (Varenicline and Nicotine E-Cigarettes Plus Counseling), Varenicline Plus Counseling
Sir Mortimer B. Davis - Jewish General Hospital
Acute Coronary Syndrome, Cardiovascular Diseases
09/25
03/27
PACIFIC, NCT05525520 / 2021-002526-25: Study to Evaluate EP547 in Subjects With Cholestatic Pruritus Due to Primary Biliary Cholangitis or Primary Sclerosing Cholangitis

Completed
2
62
Europe, Canada, US, RoW
EP547, Placebo
Escient Pharmaceuticals, Inc, Escient Pharmaceuticals, Inc.
Pruritus
07/24
09/24
VISTAS, NCT04663308 / 2020-003027-41: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

Recruiting
2
200
Europe, Canada, US, RoW
Volixibat, SHP626, Placebo
Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc.
Primary Sclerosing Cholangitis
09/25
12/25
Perri, Roman
NCT05677971: Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein

Recruiting
3
160
Europe, Canada, US, RoW
Fazirsiran Injection, TAK-999, ARO-AAT, ADS-001, Placebo, Sodium chloride
Takeda, Takeda Development Center Americas, Inc.
Alpha1-Antitrypsin Deficiency
03/27
03/29
VISTAS, NCT04663308 / 2020-003027-41: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

Recruiting
2
200
Europe, Canada, US, RoW
Volixibat, SHP626, Placebo
Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc.
Primary Sclerosing Cholangitis
09/25
12/25
INTERLIVER, NCT03193151: Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation

Recruiting
N/A
300
Europe, Canada, US, RoW
liver biopsy
University of Alberta
Liver Dysfunction
12/25
12/26
 

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