USC University Hospital
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 67 Trials 
135 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Weaver, Fred A
BeAT-HF, NCT02627196: Baroreflex Activation Therapy for Heart Failure

Active, not recruiting
N/A
1200
Europe, US
BAROSTIM NEO® System, Medical Management
CVRx, Inc.
Heart Failure
12/23
12/23
NCT04600791: BATwire Implant Kit

Terminated
N/A
93
US
BATwire Implant Kit
CVRx, Inc.
Heart Failure
08/24
02/25
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Mayo Clinic, National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
GREAT, NCT01658787: Global Registry for Endovascular Aortic Treatment

Active, not recruiting
N/A
4600
Europe, US, RoW
Endovascular aortic repair
W.L.Gore & Associates
Multiple Pathologies
06/27
06/27
Macdonald, Heather
NCT05837234: Ultra Low Frequency Spinal Cord Stimulation for Chronic Low Back Pain

Recruiting
N/A
55
RoW
ULF SCS
Presidio Medical, Inc
Chronic Pain, Chronic Low-back Pain
06/25
03/27
PREDICT, NCT03448926: The Registry:

Recruiting
N/A
3000
US
Treatment Recommendation Surveys, 7-gene biosignature
PreludeDx, University of South Florida
DCIS
12/25
12/35
Adams, David R
NCT01675440: Safety & Efficacy Study of the Medtronic CoreValve® System-Treatment of Symptomatic Severe Aortic Stenosis With Significant Comorbidities in Extreme Risk Subjects Who Need Aortic Valve Replacement

Active, not recruiting
N/A
782
US
Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Medtronic Cardiovascular
Severe Aortic Stenosis
12/16
01/26
SURTAVI, NCT01586910: Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement ().

Active, not recruiting
N/A
1746
Europe, Canada, US
Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI), Surgical Aortic Valve Replacement (SAVR), Medtronic CoreValve® Evolut R System Transcatheter Aortic Valve Implantation (TAVI)
Medtronic Cardiovascular
Severe Aortic Stenosis
07/18
11/26
NCT03645447: The Taste-Mood Diagnostic Study

Recruiting
N/A
240
Europe
Taste test
Ranvier Health Ltd
Depression
12/24
02/25
NCT02539329: Characterization of Anti-FGFR3 Antibodies

Completed
N/A
251
Europe
Neurological assessment and Blood sample
Centre Hospitalier Universitaire de Saint Etienne
Sensory Peripheral Neuropathy
11/21
01/22
ReChord, NCT02803957: Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair

Recruiting
N/A
585
US
NeoChord DS1000, Surgical Mitral Valve Repair
NeoChord
Mitral Valve Insufficiency
07/22
07/27
NCT03904147: TRILUMINATE Pivotal Trial

Active, not recruiting
N/A
572
Europe, Canada, US
TriClipTM Device
Abbott Medical Devices
Tricuspid Regurgitation
11/22
04/29
PERIGON, NCT02088554: Pivotal Trial

Active, not recruiting
N/A
1312
Europe, Canada, US
Model 400 aortic valve bioprosthesis
Medtronic Cardiac Surgery, Medtronic
Aortic Stenosis
04/23
12/35
ICE-AFIB, NCT03732794: AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment

Active, not recruiting
N/A
150
US
AtriCure CryoICE & AtriClip LAA Exclusion
AtriCure, Inc.
Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
06/24
06/26
NCT04433065: TTVR Early Feasibility Study

Recruiting
N/A
150
US
Intrepid™ TTVR System
Medtronic Cardiovascular
Tricuspid Regurgitation
07/25
07/31
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
Thourani, Vinod
PACES, NCT04045665 / 2021-005022-18: Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Recruiting
3
3200
Europe, Canada, US
Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy
Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center
Atrial Fibrillation, Stroke, Bleeding
08/26
08/26
NCT02732691: JENAVALVE AS EFS TRIAL: Pericardial TAVR Aortic Stenosis Study

Active, not recruiting
N/A
68
Europe, US, RoW
JenaValve Pericardial TAVR System
JenaValve Technology, Inc.
Aortic Valve Stenosis, Heart Valve Diseases, Heart Diseases, Cardiovascular Diseases, Ventricular Outflow Obstruction
05/19
04/24
ACTIVE, NCT03016975: Edwards Cardioband System Pivotal Clinical Trial

Terminated
N/A
12
US
Edwards Cardioband System, Transcatheter mitral valve repair (TMVr), Guideline Directed Medical Therapy
Edwards Lifesciences
Functional Mitral Regurgitation, Mitral Regurgitation, Mitral Insufficiency
07/19
09/22
NCT03539458: Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification

Completed
N/A
11
US
Tendyne Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Annular Calcification, Mitral Annulus Calcification, Cardiovascular Diseases, Valve Heart Disease, Heart Valve Diseases, Heart Valve Calcification, Mitral Valve Disease
11/19
06/24
NCT02732704: THE ALIGN-AR EFS TRIAL: JenaValve Pericardial TAVR Aortic Regurgitation Study

Active, not recruiting
N/A
100
Europe, US
JenaValve Pericardial TAVR System
JenaValve Technology, Inc.
Aortic Regurgitation
08/22
09/27
ALIGN-AR, NCT04415047: The JenaValve Pivotal Trial

Active, not recruiting
N/A
180
US
JenaValve Trilogy Heart Valve System
JenaValve Technology, Inc.
Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency, Aortic Valve Disease
08/23
08/28
RESTORE, NCT04375332: Beating Heart Mitral Valve Repair With the HARPOON™ System

Active, not recruiting
N/A
25
US
HARPOON™ Beating Heart Mitral Valve Repair System
Edwards Lifesciences
Mitral Regurgitation
12/27
12/27
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
06/26
06/31
NCT04905017: Trisol System EFS Study

Recruiting
N/A
15
US
Transcatheter Tricuspid Valve Replacement
Trisol Medical
Tricuspid Regurgitation
01/25
07/27
IMPACT SDM, NCT06171737: Promoting Shared Decision Making for Severe Aortic Stenosis

Enrolling by invitation
N/A
1300
US
Decision Aid, Shared Decision Making Skills Training
Massachusetts General Hospital, University of California, San Francisco, University of Colorado, Denver, University of North Carolina, Chapel Hill, Emory University, University of Pennsylvania, University of Texas Southwestern Medical Center, University of Washington, Patient-Centered Outcomes Research Institute
Aortic Stenosis
05/27
10/27
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
05/24
06/28
NCT05061004: Cephea Early Feasibility Study

Recruiting
N/A
50
Canada, US
Cephea Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation
03/26
03/31
NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting
N/A
1070
Europe, US
Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure
06/24
12/29
TANDEM II, NCT05913908: EFS of the DUO System for Tricuspid Regurgitation

Recruiting
N/A
15
Europe, US
DUO Transcatheter Tricuspid Coaptation Valve System, DUO System
CroiValve Limited
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases
12/25
10/29
JENA-VAD, NCT06594705: The JenaValve ALIGN-AR LVAD Registry

Not yet recruiting
N/A
50
US
JenaValve Trilogy Heart Valve System
JenaValve Technology, Inc.
Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency, Aortic Valve Disease, Left Ventricular Dysfunction
12/25
12/26
CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting
N/A
870
Canada, US
Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease
12/27
12/31
NCT06680427: Siegel™ Transcatheter Aortic Valve Replacement System (TAVR) Early Feasibility Study

Recruiting
N/A
15
US
Siegel Transcatheter Aortic Valve (TAVR)
MiRus
Aortic Stenosis Symptomatic
01/26
01/26
NCT03382457: Clinical Study of Edwards Cardioband FIT Valve Repair System

Recruiting
N/A
75
US
Transcatheter Tricuspid Valve Repair, Edwards Cardioband Tricuspid Valve Repair
Edwards Lifesciences
Tricuspid Regurgitation
12/26
12/31
ARTIST, NCT06608823: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™

Not yet recruiting
N/A
1016
US
Transcatheter Aortic Valve Replacement (TAVR) using Trilogy THV System, SAVR
JenaValve Technology, Inc.
Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency
02/26
02/36
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
PRIMARY, NCT05051033: Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds

Recruiting
N/A
450
Europe, Canada, US
Mitral valve repair, Mitral valve surgery, Transcatheter edge-to-edge repair, TEER
Annetine Gelijns, National Heart, Lung, and Blood Institute (NHLBI)
Mitral Valve Regurgitation
11/28
11/30
MOMENTIS, NCT05526560: Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

Recruiting
N/A
500
Europe, Canada, US
MITRIS RESILIA Mitral Valve, Model 11400M
Edwards Lifesciences
Mitral Stenosis, Mitral Valve Insufficiency
01/28
12/35
LeAAPS, NCT05478304: Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

Recruiting
N/A
6500
Europe, Canada, US, RoW
AtriClip LAA Exclusion System
AtriCure, Inc., Population Health Research Institute
Ischemic Stroke, Systemic Embolism
12/31
04/32
Macaluso, Matthew
SMART-BD, NCT06433635: Sequential Multiple Assignment Randomized Trial for Bipolar Depression

Not yet recruiting
4
2726
Canada, US
Cariprazine, Vraylar, Aripiprazole/Escitalopram combination, Abilify/ Lexapro, Quetiapine, Seroquel, Lurasidone, Latuda
Massachusetts General Hospital, Patient-Centered Outcomes Research Institute
Bipolar I Disorder, Depression
02/30
02/30
NCT04990687: Vagal Nerve Stimulation for Treatment Resistant Major Depression

Completed
N/A
5
US
gammaCore™
University of Alabama at Birmingham
Major Depressive Disorder
09/23
04/24
ABT-CIP-10494, NCT06423430: Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Recruiting
N/A
100
US
Sham-stimulation, Active-stimulation
Abbott Medical Devices
Treatment Resistant Depression
04/27
04/29
RECOVER, NCT03887715: A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Recruiting
N/A
6800
US
Vagus Nerve Stimulation (VNS), VNS
LivaNova
Treatment Resistant Depression
02/28
12/30
Rizik, David G
SYNIVUS-DAPT, NCT03606642: SYNergy Stent® System Implantation With Mandatory Intra-VascularUltra-Sound Guidance and Dual Anti-Platelet Therapy

Terminated
2
50
US
Dual Antiplatelet (DAPT) Therapy, Ticagrelor (Brilinta), Clopidogrel (Plavix), Prasugrel (Effient) with Aspirin, The Synergy® stent
HonorHealth Research Institute, Boston Scientific Corporation
Coronary Artery Disease, Atherosclerosis, Stent Placement
12/21
08/22
NCT03904147: TRILUMINATE Pivotal Trial

Active, not recruiting
N/A
572
Europe, Canada, US
TriClipTM Device
Abbott Medical Devices
Tricuspid Regurgitation
11/22
04/29
NCT05653336: PerQseal® Clinical Study

Active, not recruiting
N/A
149
Europe, US
PerQseal® Closure Device System
Vivasure Medical Limited
Percutaneous Large Hole Vascular Closure
12/24
06/25
JVTF EFS, NCT06034028: J-Valve TF Early Feasibility Study

Active, not recruiting
N/A
25
US
J-Valve TF System
JC Medical, Inc.
Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Regurgitation
07/24
08/29
NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting
N/A
1948
Canada, US
ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL
Boston Scientific Corporation
Aortic Stenosis
06/24
09/34
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
05/24
06/28
COSIRA-II, NCT05102019: Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II

Recruiting
N/A
380
Canada, US
Arm 1: treatment with Shockwave Reducer, Arm 2 (control): Implantation procedure with no device implanted, Arm 3 (unblinded, non-randomized): Single arm registry
Shockwave Medical, Inc., Shockwave Medical, Inc.
Refractory Angina
07/27
01/32
JOURNEY, NCT06455787: J-Valve Transfemoral Pivotal Study

Recruiting
N/A
194
US
J-Valve Transfemoral (TF) System
JC Medical, Inc., Bright Research Partners, Minneapolis Heart Institute Foundation, Cardiovascular Research Foundation, New York
Aortic Valve Regurgitation, Aortic Valve Disease Mixed
12/27
12/31
DTU-STEMI, NCT03947619: Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: the STEMI-DTU Trial

Active, not recruiting
N/A
527
Europe, Canada, US
Impella CP® placement prior to reperfusion with Primary PCI
Abiomed Inc.
ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
09/24
10/30
SPIRIT XLV PAS, NCT05423379: XIENCE Skypoint Large Vessel Post Approval Study

Active, not recruiting
N/A
102
Europe, US
XIENCE Skypoint Large Vessel Everolimus Eluting Coronary Stent System (EECSS)
Abbott Medical Devices
Coronary Artery Disease
08/25
08/27
NCT05149755: Evolut™ EXPAND TAVR II Pivotal Trial

Recruiting
N/A
650
Europe, Canada, Japan, US, RoW
Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT)
Medtronic Cardiovascular
Moderate Aortic Valve Stenosis
02/26
12/34
Matthews, Ray
NCT02661451: Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

Active, not recruiting
N/A
178
Europe, Canada, US
SAPIEN 3 THV, Optimal Heart Failure Therapy
Cardiovascular Research Foundation, New York, Cardialysis BV, Avania
Aortic Valve Stenosis
02/23
02/25
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
NCT03142152: The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Recruiting
N/A
300
Europe, Canada, US
Carillon Mitral Contour System, Carillon, Percutaneous mitral valve repair, Guideline Directed Heart Failure Medication
Cardiac Dimensions, Inc.
Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
12/26
12/30
Starnes, Vaughn
PACES, NCT04045665 / 2021-005022-18: Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Recruiting
3
3200
Europe, Canada, US
Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy
Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center
Atrial Fibrillation, Stroke, Bleeding
08/26
08/26
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
MVSS, NCT04736667: Mitral Valve Screening Survey

Recruiting
N/A
1000
Canada, US
Medstar Health Research Institute
Mitral Valve Disease
02/27
02/27
EMPRO, NCT06027788: CTSN Embolic Protection Trial

Recruiting
N/A
842
Canada, US
CardioGard Embolic Protection Cannula, Standard Aortic Cannula
Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI)
Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease, Coronary Artery Disease
04/27
04/27
PRIMARY, NCT05051033: Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds

Recruiting
N/A
450
Europe, Canada, US
Mitral valve repair, Mitral valve surgery, Transcatheter edge-to-edge repair, TEER
Annetine Gelijns, National Heart, Lung, and Blood Institute (NHLBI)
Mitral Valve Regurgitation
11/28
11/30
Yoon, Andrew
NCT06142383: A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure

Terminated
2
136
Europe, Japan, US, RoW
Placebo, XXB750 Low dose, XXB750 Medium Dose, XXB750 High Dose, Sacubitril/valsartan
Novartis Pharmaceuticals
Heart Failure
11/24
11/24
REVERSE-HF, NCT05318105: Ultrafiltration Versus IV Diuretics in Worsening Heart Failure

Recruiting
N/A
372
US
Aquadex Smartflow® System, IV Loop Diuretics
Nuwellis, Inc.
Heart Failure (for Example, Fluid Overload)
07/25
10/25
Doshi, Rahul
CHANGE AFIB, NCT05130268: Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation

Completed
4
339
US
Dronedarone, Multaq
American Heart Association, Duke Clinical Research Institute, Sanofi
Atrial Fibrillation
01/24
06/24
NCT04680026 / 2022-001021-74: A Study of IV HBI-3000 for the Conversion Recent Onset Atrial Fibrillation (AF)

Active, not recruiting
2
150
Canada, US, RoW
HBI-3000, sulcardine sulfate, Placebo
HUYABIO International, LLC., HUYABIO International, LLC
Atrial Fibrillation
06/25
06/25
NCT05327101: Patient Preferences for Leadless Pacemakers

Completed
N/A
117
US
Patient Preference Survey
Abbott Medical Devices
Cardiac Rhythm Disorder, Bradycardia, Cardiac Pacemaker Artificial
06/23
06/23
SyncAV, NCT04100148: Post-Market Trial

Active, not recruiting
N/A
1686
Europe, Canada, Japan, US, RoW
SyncAV programmed ON, Fixed AV delay
Abbott Medical Devices
Congestive Heart Failure
06/25
12/25
INTEGRA-D, NCT05855135: Assessment of Combined CCM and ICD Device in HFrEF

Recruiting
N/A
300
US
OPTIMIZER® Integra CCM-D System (Treatment Arm)
Impulse Dynamics
Heart Failure, Heart Failure With Reduced Ejection Fraction, Implantable Defibrillator User, CCM Therapy, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy, Sudden Cardiac Arrest, Arrhythmias, Cardiac, Ventricular Tachycardia, Ventricular Fibrillation
06/25
12/25
NCT04600791: BATwire Implant Kit

Terminated
N/A
93
US
BATwire Implant Kit
CVRx, Inc.
Heart Failure
08/24
02/25
ADVENT PAS, NCT06431815: ADVENT Post Approval Study

Recruiting
N/A
220
Canada, US, RoW
FARAPULSE™ Pulsed Field Ablation System, FARAWAVE™ Pulsed Field Ablation Catheter
Boston Scientific Corporation
Paroxysmal Atrial Fibrillation
10/28
10/29
NCT06676072: A Study of the TactiFlex SE Catheter and Volt PFA Generator in Subjects With PAF:

Recruiting
N/A
188
Europe, US
PFA Ablation catheter
Abbott Medical Devices
Atrial Fibrillation (AF), Atrial Arrhythmia, Paroxysmal AF, Drug Refractory Paroxysmal Atrial Fibrillation
04/26
04/26
NCT03643224: DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation

Completed
N/A
376
Europe, Canada, US, RoW
Radiofrequency Ablation
Medtronic Cardiac Ablation Solutions
Persistent Atrial Fibrillation, Atrial Fibrillation
10/24
10/24
Sundareswaran, Kartik
NCT03539458: Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification

Completed
N/A
11
US
Tendyne Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Annular Calcification, Mitral Annulus Calcification, Cardiovascular Diseases, Valve Heart Disease, Heart Valve Diseases, Heart Valve Calcification, Mitral Valve Disease
11/19
06/24
NCT04177394: MitraClip EXPAND G4 Study

Active, not recruiting
N/A
1064
Europe, Canada, Japan, US, RoW
MitraClip G4 System
Abbott Medical Devices, Abbott
Mitral Valve Regurgitation, Mitral Regurgitation
05/22
03/28
bRIGHT, NCT04483089: An Observational Real-world Study Evaluating Severe Tricuspid Regurgitation Patients Treated with the Abbott TriClip™ Device

Active, not recruiting
N/A
511
Europe
Transcatheter heart valve procedure
Abbott Medical Devices
Tricuspid Valve Regurgitation
12/27
01/28
Sorajja, Paul
NCT03539458: Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification

Completed
N/A
11
US
Tendyne Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Annular Calcification, Mitral Annulus Calcification, Cardiovascular Diseases, Valve Heart Disease, Heart Valve Diseases, Heart Valve Calcification, Mitral Valve Disease
11/19
06/24
NCT03904147: TRILUMINATE Pivotal Trial

Active, not recruiting
N/A
572
Europe, Canada, US
TriClipTM Device
Abbott Medical Devices
Tricuspid Regurgitation
11/22
04/29
NCT04029337: An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

Recruiting
N/A
30
US
Transcatheter Mitral Valve Replacement
HighLife SAS
Mitral Regurgitation
12/25
12/30
NCT04091048: Optimize PRO Study

Completed
N/A
1127
Europe, Canada, US, RoW
Evolut™ PRO and Evolut™ PRO+ System (Evolut™ FX System for the addendum)
Medtronic Cardiovascular
Symptomatic Aortic Stenosis
12/23
11/24
NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting
N/A
1948
Canada, US
ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL
Boston Scientific Corporation
Aortic Stenosis
06/24
09/34
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
05/24
06/28
TRICAV, NCT06137807: TRIcvalve BiCAVal Valve System for Severe Tricuspid Regurgitation (-I)

Recruiting
N/A
50
US
TricValve® Transcatheter Bicaval Valve System, TricValve System
P+F Products + Features USA Inc., P+F Products + Features GmbH, Meditrial USA Inc.
Tricuspid Regurgitation, Tricuspid Valve Disease
11/25
09/29
TANDEM II, NCT05913908: EFS of the DUO System for Tricuspid Regurgitation

Recruiting
N/A
15
Europe, US
DUO Transcatheter Tricuspid Coaptation Valve System, DUO System
CroiValve Limited
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases
12/25
10/29
TRICURE EFS, NCT06506942: The Study

Recruiting
N/A
10
US
Transcatheter Tricuspid Valve Replacement, TRiCares Topaz Tricuspid Valve Replacement System
TRiCares
Tricuspid Valve Regurgitation, Heart Valve Diseases, Cardiovascular Diseases
10/25
10/30
NCT04433065: TTVR Early Feasibility Study

Recruiting
N/A
150
US
Intrepid™ TTVR System
Medtronic Cardiovascular
Tricuspid Regurgitation
07/25
07/31
NCT03523416: Early Feasibility Study - Edwards APTURE Transcatheter Shunt System

Active, not recruiting
N/A
71
US
Transcatheter Atrial Shunt System
Edwards Lifesciences
Heart Failure
12/23
11/28
RESTORE, NCT06777368: REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Recruiting
N/A
225
US
Medtronic TAV, Edwards TAV
Medtronic Cardiovascular
Aortic Stenosis
03/29
07/33
NCT05149755: Evolut™ EXPAND TAVR II Pivotal Trial

Recruiting
N/A
650
Europe, Canada, Japan, US, RoW
Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT)
Medtronic Cardiovascular
Moderate Aortic Valve Stenosis
02/26
12/34
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
Mullin, Stephanie
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
05/24
06/28
MOMENTIS, NCT05526560: Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

Recruiting
N/A
500
Europe, Canada, US
MITRIS RESILIA Mitral Valve, Model 11400M
Edwards Lifesciences
Mitral Stenosis, Mitral Valve Insufficiency
01/28
12/35
LeAAPS, NCT05478304: Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

Recruiting
N/A
6500
Europe, Canada, US, RoW
AtriClip LAA Exclusion System
AtriCure, Inc., Population Health Research Institute
Ischemic Stroke, Systemic Embolism
12/31
04/32
Ramos, Melissa
SIMPLE, NCT04773392: Simplified IMmunosuppressive Protocol Utilizing Low Dose EnvarsusXR

Recruiting
4
80
US
Twice-daily Tacrolimus, Once-daily envarsus XR, Induction Immunosuppression with Basiliximab or Rabbit Anti Thymoglobulin (rATG), Methylprednisolone, prednisone, Steroids, Mycophenolate mofetil (MMF) or Mycophenolic acid (MPA), Twice a day anti-metabolite, Azathioprine, Once a day anti-metabolite
University of Southern California, Veloxis Pharmaceuticals
Kidney Transplantation, Kidney Transplant Rejection
02/25
02/25
LIMT-2, NCT05070364 / 2021-003665-35: Phase 3 Study to Evaluate the Efficacy and Safety of Peginterferon Lambda for 48 Weeks in Patients With Chronic HDV

Active, not recruiting
3
150
Europe, US, RoW
Peginterferon Lambda-1a, Lambda, Peginterferon Lambda, Pegylated Interferon Lambda
Eiger BioPharmaceuticals, Eiger BioPharmaceuticals, Inc.
Hepatitis Delta Virus
06/24
01/25
NCT02438306: CardiAMP™ Cell Therapy for Heart Failure Trial

Active, not recruiting
3
125
Canada, US
Autologous cell therapy, Sham
BioCardia, Inc.
Heart Failure, Systolic
12/24
12/26
NCT05143177: A Study to Evaluate the Efficacy and Safety of DA-1229 (Evogliptin) in Patient's Calcific Aortic Valve Disease with Mild to Moderate Aortic Stenosis (EVOID-AS)

Active, not recruiting
2/3
867
Canada, US
Evogliptin, DA-1229, Placebo
REDNVIA Co., Ltd.
Calcific Aortic Valve Disease
05/26
12/26
I-SPY_COVID, NCT04488081: I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients

Recruiting
2
1500
US
Remdesivir, GS-5734, Imatinib Mesylate, Dexamethasone, Cenicriviroc, Icatibant, Firazyr, Apremilast, Otezla, dornase alfa, Pulmozyme, Celecoxib, celebrex, Famotidine, Pepcid, IC14, Aviptadil, Zyesami, narsoplimab, OMS721, Cyproheptadine, periactin, Cyclosporine, CsA
QuantumLeap Healthcare Collaborative, University of California, San Francisco, University of Pennsylvania, Emory University, University of Alabama at Birmingham, University of Colorado, Denver, University of Southern California, Yale University, Wake Forest University Health Sciences, Sanford Health, Long Beach Memorial Medical Center, Georgetown University, University of California, Davis, Hoag Memorial Hospital Presbyterian, Main Line Health, DHR Health Institute for Research and Development, University of California, Irvine, Corewell Health, Kaiser Permanente, University of Michigan, West Virginia University, University of Miami, University Hospitals Cleveland Medical Center, Virtua Health, M.D. Anderson Cancer Center
COVID-19
07/28
07/30
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Weaver, Fred A
BeAT-HF, NCT02627196: Baroreflex Activation Therapy for Heart Failure

Active, not recruiting
N/A
1200
Europe, US
BAROSTIM NEO® System, Medical Management
CVRx, Inc.
Heart Failure
12/23
12/23
NCT04600791: BATwire Implant Kit

Terminated
N/A
93
US
BATwire Implant Kit
CVRx, Inc.
Heart Failure
08/24
02/25
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Mayo Clinic, National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
GREAT, NCT01658787: Global Registry for Endovascular Aortic Treatment

Active, not recruiting
N/A
4600
Europe, US, RoW
Endovascular aortic repair
W.L.Gore & Associates
Multiple Pathologies
06/27
06/27
Macdonald, Heather
NCT05837234: Ultra Low Frequency Spinal Cord Stimulation for Chronic Low Back Pain

Recruiting
N/A
55
RoW
ULF SCS
Presidio Medical, Inc
Chronic Pain, Chronic Low-back Pain
06/25
03/27
PREDICT, NCT03448926: The Registry:

Recruiting
N/A
3000
US
Treatment Recommendation Surveys, 7-gene biosignature
PreludeDx, University of South Florida
DCIS
12/25
12/35
Adams, David R
NCT01675440: Safety & Efficacy Study of the Medtronic CoreValve® System-Treatment of Symptomatic Severe Aortic Stenosis With Significant Comorbidities in Extreme Risk Subjects Who Need Aortic Valve Replacement

Active, not recruiting
N/A
782
US
Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI)
Medtronic Cardiovascular
Severe Aortic Stenosis
12/16
01/26
SURTAVI, NCT01586910: Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement ().

Active, not recruiting
N/A
1746
Europe, Canada, US
Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI), Surgical Aortic Valve Replacement (SAVR), Medtronic CoreValve® Evolut R System Transcatheter Aortic Valve Implantation (TAVI)
Medtronic Cardiovascular
Severe Aortic Stenosis
07/18
11/26
NCT03645447: The Taste-Mood Diagnostic Study

Recruiting
N/A
240
Europe
Taste test
Ranvier Health Ltd
Depression
12/24
02/25
NCT02539329: Characterization of Anti-FGFR3 Antibodies

Completed
N/A
251
Europe
Neurological assessment and Blood sample
Centre Hospitalier Universitaire de Saint Etienne
Sensory Peripheral Neuropathy
11/21
01/22
ReChord, NCT02803957: Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair

Recruiting
N/A
585
US
NeoChord DS1000, Surgical Mitral Valve Repair
NeoChord
Mitral Valve Insufficiency
07/22
07/27
NCT03904147: TRILUMINATE Pivotal Trial

Active, not recruiting
N/A
572
Europe, Canada, US
TriClipTM Device
Abbott Medical Devices
Tricuspid Regurgitation
11/22
04/29
PERIGON, NCT02088554: Pivotal Trial

Active, not recruiting
N/A
1312
Europe, Canada, US
Model 400 aortic valve bioprosthesis
Medtronic Cardiac Surgery, Medtronic
Aortic Stenosis
04/23
12/35
ICE-AFIB, NCT03732794: AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment

Active, not recruiting
N/A
150
US
AtriCure CryoICE & AtriClip LAA Exclusion
AtriCure, Inc.
Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
06/24
06/26
NCT04433065: TTVR Early Feasibility Study

Recruiting
N/A
150
US
Intrepid™ TTVR System
Medtronic Cardiovascular
Tricuspid Regurgitation
07/25
07/31
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
Thourani, Vinod
PACES, NCT04045665 / 2021-005022-18: Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Recruiting
3
3200
Europe, Canada, US
Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy
Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center
Atrial Fibrillation, Stroke, Bleeding
08/26
08/26
NCT02732691: JENAVALVE AS EFS TRIAL: Pericardial TAVR Aortic Stenosis Study

Active, not recruiting
N/A
68
Europe, US, RoW
JenaValve Pericardial TAVR System
JenaValve Technology, Inc.
Aortic Valve Stenosis, Heart Valve Diseases, Heart Diseases, Cardiovascular Diseases, Ventricular Outflow Obstruction
05/19
04/24
ACTIVE, NCT03016975: Edwards Cardioband System Pivotal Clinical Trial

Terminated
N/A
12
US
Edwards Cardioband System, Transcatheter mitral valve repair (TMVr), Guideline Directed Medical Therapy
Edwards Lifesciences
Functional Mitral Regurgitation, Mitral Regurgitation, Mitral Insufficiency
07/19
09/22
NCT03539458: Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification

Completed
N/A
11
US
Tendyne Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Annular Calcification, Mitral Annulus Calcification, Cardiovascular Diseases, Valve Heart Disease, Heart Valve Diseases, Heart Valve Calcification, Mitral Valve Disease
11/19
06/24
NCT02732704: THE ALIGN-AR EFS TRIAL: JenaValve Pericardial TAVR Aortic Regurgitation Study

Active, not recruiting
N/A
100
Europe, US
JenaValve Pericardial TAVR System
JenaValve Technology, Inc.
Aortic Regurgitation
08/22
09/27
ALIGN-AR, NCT04415047: The JenaValve Pivotal Trial

Active, not recruiting
N/A
180
US
JenaValve Trilogy Heart Valve System
JenaValve Technology, Inc.
Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency, Aortic Valve Disease
08/23
08/28
RESTORE, NCT04375332: Beating Heart Mitral Valve Repair With the HARPOON™ System

Active, not recruiting
N/A
25
US
HARPOON™ Beating Heart Mitral Valve Repair System
Edwards Lifesciences
Mitral Regurgitation
12/27
12/27
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
06/26
06/31
NCT04905017: Trisol System EFS Study

Recruiting
N/A
15
US
Transcatheter Tricuspid Valve Replacement
Trisol Medical
Tricuspid Regurgitation
01/25
07/27
IMPACT SDM, NCT06171737: Promoting Shared Decision Making for Severe Aortic Stenosis

Enrolling by invitation
N/A
1300
US
Decision Aid, Shared Decision Making Skills Training
Massachusetts General Hospital, University of California, San Francisco, University of Colorado, Denver, University of North Carolina, Chapel Hill, Emory University, University of Pennsylvania, University of Texas Southwestern Medical Center, University of Washington, Patient-Centered Outcomes Research Institute
Aortic Stenosis
05/27
10/27
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
05/24
06/28
NCT05061004: Cephea Early Feasibility Study

Recruiting
N/A
50
Canada, US
Cephea Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation
03/26
03/31
NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting
N/A
1070
Europe, US
Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure
06/24
12/29
TANDEM II, NCT05913908: EFS of the DUO System for Tricuspid Regurgitation

Recruiting
N/A
15
Europe, US
DUO Transcatheter Tricuspid Coaptation Valve System, DUO System
CroiValve Limited
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases
12/25
10/29
JENA-VAD, NCT06594705: The JenaValve ALIGN-AR LVAD Registry

Not yet recruiting
N/A
50
US
JenaValve Trilogy Heart Valve System
JenaValve Technology, Inc.
Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency, Aortic Valve Disease, Left Ventricular Dysfunction
12/25
12/26
CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting
N/A
870
Canada, US
Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease
12/27
12/31
NCT06680427: Siegel™ Transcatheter Aortic Valve Replacement System (TAVR) Early Feasibility Study

Recruiting
N/A
15
US
Siegel Transcatheter Aortic Valve (TAVR)
MiRus
Aortic Stenosis Symptomatic
01/26
01/26
NCT03382457: Clinical Study of Edwards Cardioband FIT Valve Repair System

Recruiting
N/A
75
US
Transcatheter Tricuspid Valve Repair, Edwards Cardioband Tricuspid Valve Repair
Edwards Lifesciences
Tricuspid Regurgitation
12/26
12/31
ARTIST, NCT06608823: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™

Not yet recruiting
N/A
1016
US
Transcatheter Aortic Valve Replacement (TAVR) using Trilogy THV System, SAVR
JenaValve Technology, Inc.
Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency
02/26
02/36
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
PRIMARY, NCT05051033: Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds

Recruiting
N/A
450
Europe, Canada, US
Mitral valve repair, Mitral valve surgery, Transcatheter edge-to-edge repair, TEER
Annetine Gelijns, National Heart, Lung, and Blood Institute (NHLBI)
Mitral Valve Regurgitation
11/28
11/30
MOMENTIS, NCT05526560: Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

Recruiting
N/A
500
Europe, Canada, US
MITRIS RESILIA Mitral Valve, Model 11400M
Edwards Lifesciences
Mitral Stenosis, Mitral Valve Insufficiency
01/28
12/35
LeAAPS, NCT05478304: Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

Recruiting
N/A
6500
Europe, Canada, US, RoW
AtriClip LAA Exclusion System
AtriCure, Inc., Population Health Research Institute
Ischemic Stroke, Systemic Embolism
12/31
04/32
Macaluso, Matthew
SMART-BD, NCT06433635: Sequential Multiple Assignment Randomized Trial for Bipolar Depression

Not yet recruiting
4
2726
Canada, US
Cariprazine, Vraylar, Aripiprazole/Escitalopram combination, Abilify/ Lexapro, Quetiapine, Seroquel, Lurasidone, Latuda
Massachusetts General Hospital, Patient-Centered Outcomes Research Institute
Bipolar I Disorder, Depression
02/30
02/30
NCT04990687: Vagal Nerve Stimulation for Treatment Resistant Major Depression

Completed
N/A
5
US
gammaCore™
University of Alabama at Birmingham
Major Depressive Disorder
09/23
04/24
ABT-CIP-10494, NCT06423430: Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Recruiting
N/A
100
US
Sham-stimulation, Active-stimulation
Abbott Medical Devices
Treatment Resistant Depression
04/27
04/29
RECOVER, NCT03887715: A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Recruiting
N/A
6800
US
Vagus Nerve Stimulation (VNS), VNS
LivaNova
Treatment Resistant Depression
02/28
12/30
Rizik, David G
SYNIVUS-DAPT, NCT03606642: SYNergy Stent® System Implantation With Mandatory Intra-VascularUltra-Sound Guidance and Dual Anti-Platelet Therapy

Terminated
2
50
US
Dual Antiplatelet (DAPT) Therapy, Ticagrelor (Brilinta), Clopidogrel (Plavix), Prasugrel (Effient) with Aspirin, The Synergy® stent
HonorHealth Research Institute, Boston Scientific Corporation
Coronary Artery Disease, Atherosclerosis, Stent Placement
12/21
08/22
NCT03904147: TRILUMINATE Pivotal Trial

Active, not recruiting
N/A
572
Europe, Canada, US
TriClipTM Device
Abbott Medical Devices
Tricuspid Regurgitation
11/22
04/29
NCT05653336: PerQseal® Clinical Study

Active, not recruiting
N/A
149
Europe, US
PerQseal® Closure Device System
Vivasure Medical Limited
Percutaneous Large Hole Vascular Closure
12/24
06/25
JVTF EFS, NCT06034028: J-Valve TF Early Feasibility Study

Active, not recruiting
N/A
25
US
J-Valve TF System
JC Medical, Inc.
Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Regurgitation
07/24
08/29
NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting
N/A
1948
Canada, US
ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL
Boston Scientific Corporation
Aortic Stenosis
06/24
09/34
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
05/24
06/28
COSIRA-II, NCT05102019: Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II

Recruiting
N/A
380
Canada, US
Arm 1: treatment with Shockwave Reducer, Arm 2 (control): Implantation procedure with no device implanted, Arm 3 (unblinded, non-randomized): Single arm registry
Shockwave Medical, Inc., Shockwave Medical, Inc.
Refractory Angina
07/27
01/32
JOURNEY, NCT06455787: J-Valve Transfemoral Pivotal Study

Recruiting
N/A
194
US
J-Valve Transfemoral (TF) System
JC Medical, Inc., Bright Research Partners, Minneapolis Heart Institute Foundation, Cardiovascular Research Foundation, New York
Aortic Valve Regurgitation, Aortic Valve Disease Mixed
12/27
12/31
DTU-STEMI, NCT03947619: Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: the STEMI-DTU Trial

Active, not recruiting
N/A
527
Europe, Canada, US
Impella CP® placement prior to reperfusion with Primary PCI
Abiomed Inc.
ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
09/24
10/30
SPIRIT XLV PAS, NCT05423379: XIENCE Skypoint Large Vessel Post Approval Study

Active, not recruiting
N/A
102
Europe, US
XIENCE Skypoint Large Vessel Everolimus Eluting Coronary Stent System (EECSS)
Abbott Medical Devices
Coronary Artery Disease
08/25
08/27
NCT05149755: Evolut™ EXPAND TAVR II Pivotal Trial

Recruiting
N/A
650
Europe, Canada, Japan, US, RoW
Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT)
Medtronic Cardiovascular
Moderate Aortic Valve Stenosis
02/26
12/34
Matthews, Ray
NCT02661451: Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

Active, not recruiting
N/A
178
Europe, Canada, US
SAPIEN 3 THV, Optimal Heart Failure Therapy
Cardiovascular Research Foundation, New York, Cardialysis BV, Avania
Aortic Valve Stenosis
02/23
02/25
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
NCT03142152: The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Recruiting
N/A
300
Europe, Canada, US
Carillon Mitral Contour System, Carillon, Percutaneous mitral valve repair, Guideline Directed Heart Failure Medication
Cardiac Dimensions, Inc.
Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
12/26
12/30
Starnes, Vaughn
PACES, NCT04045665 / 2021-005022-18: Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Recruiting
3
3200
Europe, Canada, US
Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy
Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center
Atrial Fibrillation, Stroke, Bleeding
08/26
08/26
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
MVSS, NCT04736667: Mitral Valve Screening Survey

Recruiting
N/A
1000
Canada, US
Medstar Health Research Institute
Mitral Valve Disease
02/27
02/27
EMPRO, NCT06027788: CTSN Embolic Protection Trial

Recruiting
N/A
842
Canada, US
CardioGard Embolic Protection Cannula, Standard Aortic Cannula
Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI)
Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease, Coronary Artery Disease
04/27
04/27
PRIMARY, NCT05051033: Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds

Recruiting
N/A
450
Europe, Canada, US
Mitral valve repair, Mitral valve surgery, Transcatheter edge-to-edge repair, TEER
Annetine Gelijns, National Heart, Lung, and Blood Institute (NHLBI)
Mitral Valve Regurgitation
11/28
11/30
Yoon, Andrew
NCT06142383: A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure

Terminated
2
136
Europe, Japan, US, RoW
Placebo, XXB750 Low dose, XXB750 Medium Dose, XXB750 High Dose, Sacubitril/valsartan
Novartis Pharmaceuticals
Heart Failure
11/24
11/24
REVERSE-HF, NCT05318105: Ultrafiltration Versus IV Diuretics in Worsening Heart Failure

Recruiting
N/A
372
US
Aquadex Smartflow® System, IV Loop Diuretics
Nuwellis, Inc.
Heart Failure (for Example, Fluid Overload)
07/25
10/25
Doshi, Rahul
CHANGE AFIB, NCT05130268: Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation

Completed
4
339
US
Dronedarone, Multaq
American Heart Association, Duke Clinical Research Institute, Sanofi
Atrial Fibrillation
01/24
06/24
NCT04680026 / 2022-001021-74: A Study of IV HBI-3000 for the Conversion Recent Onset Atrial Fibrillation (AF)

Active, not recruiting
2
150
Canada, US, RoW
HBI-3000, sulcardine sulfate, Placebo
HUYABIO International, LLC., HUYABIO International, LLC
Atrial Fibrillation
06/25
06/25
NCT05327101: Patient Preferences for Leadless Pacemakers

Completed
N/A
117
US
Patient Preference Survey
Abbott Medical Devices
Cardiac Rhythm Disorder, Bradycardia, Cardiac Pacemaker Artificial
06/23
06/23
SyncAV, NCT04100148: Post-Market Trial

Active, not recruiting
N/A
1686
Europe, Canada, Japan, US, RoW
SyncAV programmed ON, Fixed AV delay
Abbott Medical Devices
Congestive Heart Failure
06/25
12/25
INTEGRA-D, NCT05855135: Assessment of Combined CCM and ICD Device in HFrEF

Recruiting
N/A
300
US
OPTIMIZER® Integra CCM-D System (Treatment Arm)
Impulse Dynamics
Heart Failure, Heart Failure With Reduced Ejection Fraction, Implantable Defibrillator User, CCM Therapy, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy, Sudden Cardiac Arrest, Arrhythmias, Cardiac, Ventricular Tachycardia, Ventricular Fibrillation
06/25
12/25
NCT04600791: BATwire Implant Kit

Terminated
N/A
93
US
BATwire Implant Kit
CVRx, Inc.
Heart Failure
08/24
02/25
ADVENT PAS, NCT06431815: ADVENT Post Approval Study

Recruiting
N/A
220
Canada, US, RoW
FARAPULSE™ Pulsed Field Ablation System, FARAWAVE™ Pulsed Field Ablation Catheter
Boston Scientific Corporation
Paroxysmal Atrial Fibrillation
10/28
10/29
NCT06676072: A Study of the TactiFlex SE Catheter and Volt PFA Generator in Subjects With PAF:

Recruiting
N/A
188
Europe, US
PFA Ablation catheter
Abbott Medical Devices
Atrial Fibrillation (AF), Atrial Arrhythmia, Paroxysmal AF, Drug Refractory Paroxysmal Atrial Fibrillation
04/26
04/26
NCT03643224: DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation

Completed
N/A
376
Europe, Canada, US, RoW
Radiofrequency Ablation
Medtronic Cardiac Ablation Solutions
Persistent Atrial Fibrillation, Atrial Fibrillation
10/24
10/24
Sundareswaran, Kartik
NCT03539458: Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification

Completed
N/A
11
US
Tendyne Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Annular Calcification, Mitral Annulus Calcification, Cardiovascular Diseases, Valve Heart Disease, Heart Valve Diseases, Heart Valve Calcification, Mitral Valve Disease
11/19
06/24
NCT04177394: MitraClip EXPAND G4 Study

Active, not recruiting
N/A
1064
Europe, Canada, Japan, US, RoW
MitraClip G4 System
Abbott Medical Devices, Abbott
Mitral Valve Regurgitation, Mitral Regurgitation
05/22
03/28
bRIGHT, NCT04483089: An Observational Real-world Study Evaluating Severe Tricuspid Regurgitation Patients Treated with the Abbott TriClip™ Device

Active, not recruiting
N/A
511
Europe
Transcatheter heart valve procedure
Abbott Medical Devices
Tricuspid Valve Regurgitation
12/27
01/28
Sorajja, Paul
NCT03539458: Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification

Completed
N/A
11
US
Tendyne Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Annular Calcification, Mitral Annulus Calcification, Cardiovascular Diseases, Valve Heart Disease, Heart Valve Diseases, Heart Valve Calcification, Mitral Valve Disease
11/19
06/24
NCT03904147: TRILUMINATE Pivotal Trial

Active, not recruiting
N/A
572
Europe, Canada, US
TriClipTM Device
Abbott Medical Devices
Tricuspid Regurgitation
11/22
04/29
NCT04029337: An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

Recruiting
N/A
30
US
Transcatheter Mitral Valve Replacement
HighLife SAS
Mitral Regurgitation
12/25
12/30
NCT04091048: Optimize PRO Study

Completed
N/A
1127
Europe, Canada, US, RoW
Evolut™ PRO and Evolut™ PRO+ System (Evolut™ FX System for the addendum)
Medtronic Cardiovascular
Symptomatic Aortic Stenosis
12/23
11/24
NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

Active, not recruiting
N/A
1948
Canada, US
ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL
Boston Scientific Corporation
Aortic Stenosis
06/24
09/34
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
05/24
06/28
TRICAV, NCT06137807: TRIcvalve BiCAVal Valve System for Severe Tricuspid Regurgitation (-I)

Recruiting
N/A
50
US
TricValve® Transcatheter Bicaval Valve System, TricValve System
P+F Products + Features USA Inc., P+F Products + Features GmbH, Meditrial USA Inc.
Tricuspid Regurgitation, Tricuspid Valve Disease
11/25
09/29
TANDEM II, NCT05913908: EFS of the DUO System for Tricuspid Regurgitation

Recruiting
N/A
15
Europe, US
DUO Transcatheter Tricuspid Coaptation Valve System, DUO System
CroiValve Limited
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases
12/25
10/29
TRICURE EFS, NCT06506942: The Study

Recruiting
N/A
10
US
Transcatheter Tricuspid Valve Replacement, TRiCares Topaz Tricuspid Valve Replacement System
TRiCares
Tricuspid Valve Regurgitation, Heart Valve Diseases, Cardiovascular Diseases
10/25
10/30
NCT04433065: TTVR Early Feasibility Study

Recruiting
N/A
150
US
Intrepid™ TTVR System
Medtronic Cardiovascular
Tricuspid Regurgitation
07/25
07/31
NCT03523416: Early Feasibility Study - Edwards APTURE Transcatheter Shunt System

Active, not recruiting
N/A
71
US
Transcatheter Atrial Shunt System
Edwards Lifesciences
Heart Failure
12/23
11/28
RESTORE, NCT06777368: REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

Recruiting
N/A
225
US
Medtronic TAV, Edwards TAV
Medtronic Cardiovascular
Aortic Stenosis
03/29
07/33
NCT05149755: Evolut™ EXPAND TAVR II Pivotal Trial

Recruiting
N/A
650
Europe, Canada, Japan, US, RoW
Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT)
Medtronic Cardiovascular
Moderate Aortic Valve Stenosis
02/26
12/34
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
Mullin, Stephanie
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
05/24
06/28
MOMENTIS, NCT05526560: Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

Recruiting
N/A
500
Europe, Canada, US
MITRIS RESILIA Mitral Valve, Model 11400M
Edwards Lifesciences
Mitral Stenosis, Mitral Valve Insufficiency
01/28
12/35
LeAAPS, NCT05478304: Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

Recruiting
N/A
6500
Europe, Canada, US, RoW
AtriClip LAA Exclusion System
AtriCure, Inc., Population Health Research Institute
Ischemic Stroke, Systemic Embolism
12/31
04/32
Ramos, Melissa
SIMPLE, NCT04773392: Simplified IMmunosuppressive Protocol Utilizing Low Dose EnvarsusXR

Recruiting
4
80
US
Twice-daily Tacrolimus, Once-daily envarsus XR, Induction Immunosuppression with Basiliximab or Rabbit Anti Thymoglobulin (rATG), Methylprednisolone, prednisone, Steroids, Mycophenolate mofetil (MMF) or Mycophenolic acid (MPA), Twice a day anti-metabolite, Azathioprine, Once a day anti-metabolite
University of Southern California, Veloxis Pharmaceuticals
Kidney Transplantation, Kidney Transplant Rejection
02/25
02/25
LIMT-2, NCT05070364 / 2021-003665-35: Phase 3 Study to Evaluate the Efficacy and Safety of Peginterferon Lambda for 48 Weeks in Patients With Chronic HDV

Active, not recruiting
3
150
Europe, US, RoW
Peginterferon Lambda-1a, Lambda, Peginterferon Lambda, Pegylated Interferon Lambda
Eiger BioPharmaceuticals, Eiger BioPharmaceuticals, Inc.
Hepatitis Delta Virus
06/24
01/25
NCT02438306: CardiAMP™ Cell Therapy for Heart Failure Trial

Active, not recruiting
3
125
Canada, US
Autologous cell therapy, Sham
BioCardia, Inc.
Heart Failure, Systolic
12/24
12/26
NCT05143177: A Study to Evaluate the Efficacy and Safety of DA-1229 (Evogliptin) in Patient's Calcific Aortic Valve Disease with Mild to Moderate Aortic Stenosis (EVOID-AS)

Active, not recruiting
2/3
867
Canada, US
Evogliptin, DA-1229, Placebo
REDNVIA Co., Ltd.
Calcific Aortic Valve Disease
05/26
12/26
I-SPY_COVID, NCT04488081: I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients

Recruiting
2
1500
US
Remdesivir, GS-5734, Imatinib Mesylate, Dexamethasone, Cenicriviroc, Icatibant, Firazyr, Apremilast, Otezla, dornase alfa, Pulmozyme, Celecoxib, celebrex, Famotidine, Pepcid, IC14, Aviptadil, Zyesami, narsoplimab, OMS721, Cyproheptadine, periactin, Cyclosporine, CsA
QuantumLeap Healthcare Collaborative, University of California, San Francisco, University of Pennsylvania, Emory University, University of Alabama at Birmingham, University of Colorado, Denver, University of Southern California, Yale University, Wake Forest University Health Sciences, Sanford Health, Long Beach Memorial Medical Center, Georgetown University, University of California, Davis, Hoag Memorial Hospital Presbyterian, Main Line Health, DHR Health Institute for Research and Development, University of California, Irvine, Corewell Health, Kaiser Permanente, University of Michigan, West Virginia University, University of Miami, University Hospitals Cleveland Medical Center, Virtua Health, M.D. Anderson Cancer Center
COVID-19
07/28
07/30
 

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