| Debus, Juergen |
HIT-1, NCT01182779: Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base |
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| Recruiting | 3 | 319 | Europe | Carbon ion, Protons | Heidelberg University | Chordoma, Tumor, Treatment | 08/15 | 08/23 | | |
METIS, NCT02831959: Pivotal, Open-label, Randomized Study of Radiosurgery with or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases from Non-small Cell Lung Cancer (NSCLC). |
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| Completed | 3 | 298 | Europe, Canada, US, RoW | NovoTTF-200M device, Best Standard of Care | NovoCure GmbH | Brain Metastases from Non-small Cell Lung Cancer (NSCLC) | 11/24 | 11/24 | | |
CyberChallenge, NCT05378633: The Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases? |
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| Recruiting | 2 | 190 | Europe | SRS, Whole Brain Radiotherapy | University Hospital Heidelberg | Brain Metastases, Nsclc | 02/25 | 02/26 | | |
| Recruiting | 2 | 30 | Europe | photon, surgical therapy, Chemotherapy | University Hospital Heidelberg | Esophagus Cancer, Stage I, Esophagus Cancer, Stage II | 01/26 | 04/26 | | |
Radcav, NCT05871307: Neoadjuvant vs. Intraoperative vs. Adjuvant Resection Cavity Radiotherapy of Brain Metastases |
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| Recruiting | 2 | 90 | Europe | Preoperative Radiotherapy, Intraoperative Radiation, Postoperative Radiotherapy | University Hospital Heidelberg | Brain Metastases, Radiotherapy | 05/26 | 05/28 | | |
INDIGO, NCT05964569: Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Low Grade Glioma |
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| Recruiting | 2 | 120 | Europe | model-guided optimization of treatment plan, standard treatment plan, no optimization | University Hospital Heidelberg | Low Grade Glioma | 11/26 | 11/28 | | |
ENCEPHALON, NCT03297788: Whole Brain Radiation Therapy Alone vs. Radiosurgery for SCLC Patients With 1-10 Brain Metastases |
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| Completed | N/A | 56 | Europe | SRS, WBRT | Juergen Debus, Heidelberg University | SCLC, Brain Metastases | 10/23 | 12/23 | | |
PAROS, NCT04083937: Prostate Cancer Patients Treated With Alternative Radiation Oncology Strategies |
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| Recruiting | N/A | 897 | Europe | Hypofractionated radiotherapy with photons, Hypofractionated radiotherapy with protons, Normofractionated radiotherapy with photons | University Hospital Heidelberg | Prostate Cancer | 04/28 | 01/29 | | |
NCT04613388: Registry Study of Proton Radiotherapy in Lymphoma |
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| Recruiting | N/A | 200 | Europe | Assesment of Effectiveness and side effects | University Hospital Heidelberg | Mediastinal Lymphoma | 08/25 | 08/26 | | |
PUMA, NCT05237453: Pulmonary Magnetic Resonance-guided Online Adaptive Radiotherapy of Locally Advanced Non-Small Cell Lung Cancer |
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| Recruiting | N/A | 30 | Europe | Photons | University Hospital Heidelberg, University Hospital Tuebingen, Ludwig-Maximilians - University of Munich, German Cancer Research Center | Non-small Cell Lung Cancer | 03/26 | 03/27 | | |
NAVIGATORR, NCT05671458: Multiparametric Imaging-based Intraoperative Navigation for Guidance of Surgical Resection and Postoperative Radiotherapy in Patients With Head-and-neck Tumors |
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| Recruiting | N/A | 60 | Europe | intraoperative navigation and creation of tumor resection maps | Juergen Debus | Head and Neck Tumors | 01/27 | 01/27 | | |
| Debus, Jürgen |
CyberChallenge, NCT05378633: The Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases? |
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| Recruiting | 2 | 190 | Europe | SRS, Whole Brain Radiotherapy | University Hospital Heidelberg | Brain Metastases, Nsclc | 02/25 | 02/26 | | |
| Active, not recruiting | 2 | 180 | Europe | Chemotherapy, all brands of 5-fluorouracil (5-FU) are allowed, all brands of Mitomycin C (MMC) are allowed, Radiation, Durvalumab, PD-L1 inhibitor | Goethe University, German Cancer Aid, AstraZeneca | Anal Cancer, Anal Carcinoma, Anal Cancer Stage III, Anal Cancer Stage II | 12/26 | 03/27 | | |
PRESTO, NCT05713838: Organ Preservation With Durvalumab-based Immunotherapy in Combination With Chemoradiation as Definitive Therapy for Early Stage Esophageal Adenocarcinoma With Indication for Radical Surgery |
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| Recruiting | 2 | 32 | Europe | Durvalumab, IMFINZI, FLOT, mFOLFOX-6, Radiotherapy | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | Esophagus Adenocarcinoma | 12/25 | 12/28 | | |
| Not yet recruiting | 2 | 276 | Europe | dose-escalated radiochemotherapy, dose-escalated radiochemotherapy with carbon ion boost, standard radiochemotherapy | Technische Universität Dresden | Head and Neck Squamous Cell Carcinoma | 09/25 | 09/27 | | |
Radcav, NCT05871307: Neoadjuvant vs. Intraoperative vs. Adjuvant Resection Cavity Radiotherapy of Brain Metastases |
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| Recruiting | 2 | 90 | Europe | Preoperative Radiotherapy, Intraoperative Radiation, Postoperative Radiotherapy | University Hospital Heidelberg | Brain Metastases, Radiotherapy | 05/26 | 05/28 | | |
MAGELLAN, NCT04925583: Magnetic Resonance Guided Adaptive Stereotactic Body Radiotherapy for Lung Tumors in Ultracentral Location |
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| Recruiting | 1 | 38 | Europe | Stereotactic body radiotherapy (SBRT) | University Hospital Heidelberg | Lung Cancer | 11/25 | 11/26 | | |
| Recruiting | N/A | 202 | Europe | intraoperative radiotherapy, IORT, whole breast irradiation, WBI | University Hospital Heidelberg | Breast Cancer | 09/24 | 05/30 | | |
NCT04437030: Multiparametric Photoacoustic Imaging in the Course of Radiation Therapy of Malignant Head and Neck Tumors |
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| Completed | N/A | 30 | Europe | MSOT Acuity Echo device | University Hospital Heidelberg | Head and Neck Cancer | 01/22 | 07/23 | | |
DILANA, NCT04094454: Intrafractional Vaginal Dilation in Anal Cancer Patients Undergoing Pelvic Radiotherapy |
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| Recruiting | N/A | 60 | Europe | special tampon with a diameter of 28mm, standard tampon with a diameter of 12-13mm | Juergen Debus | Anal Cancer | 10/24 | 10/25 | | |
CARE, NCT04185974: Carbon Ion Re-Radiotherapy in Patients With Recurrent or Progressive Locally Advanced Head-and-Neck Cancer |
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| Recruiting | N/A | 72 | Europe | C12 re-irradiation, Photon re-irradiation | University Hospital Heidelberg | Locally Advanced Head-and-Neck Cancer | 11/24 | 11/24 | | |
DELPHI, NCT03396718: De-escalation of Adjuvant Radio (chemo) Therapy for HPV-positive Head-neck Squamous Cell Carcinomas |
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| Recruiting | N/A | 304 | Europe | De-escalation radio(chemo)therapy - Level 1, De-escalation radio(chemo)therapy - Level 2, Standard radio(chemotherapy) | Technische Universität Dresden, German Cancer Research Center, National Center for Tumor Diseases (NCT) Dresden, National Center for Tumor Diseases, Heidelberg, Radiation Oncology Working Group of the German Cancer Society | Head-and-neck Squamous Cell Carcinoma | 11/29 | 11/32 | | |
| Uhl, Matthias |
| Recruiting | N/A | 64 | Europe | Proton radiation, Carbon Ion radiation | University Hospital Heidelberg | Sarcoma,Soft Tissue | 05/26 | 05/27 | | |
SACRO, NCT02986516: Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease |
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| Recruiting | N/A | 100 | Europe, Japan | Randomized Cohort, Prospective cohort | Italian Sarcoma Group | Chordoma | 09/25 | 09/25 | | |
| Arians, Nathalie |
DILANA, NCT04094454: Intrafractional Vaginal Dilation in Anal Cancer Patients Undergoing Pelvic Radiotherapy |
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| Recruiting | N/A | 60 | Europe | special tampon with a diameter of 28mm, standard tampon with a diameter of 12-13mm | Juergen Debus | Anal Cancer | 10/24 | 10/25 | | |
| Seidensaal, Katharina |
| Recruiting | N/A | 64 | Europe | Proton radiation, Carbon Ion radiation | University Hospital Heidelberg | Sarcoma,Soft Tissue | 05/26 | 05/27 | | |
| Debus, Jürrgen |
MAESTRO, NCT05027711: Magnetic Resonance-guided Adaptive Stereotactic Body Radiotherapy for Hepatic Metastases |
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| Recruiting | 2 | 90 | Europe | ITV (Internal target volume)-based Stereotactic Body Radiotherapy (ITV-SBRT), MRgSBRT (Magnetic Resonance-guided Stereotactic Body Radiotherapy) | University Hospital Heidelberg | Hepatic Metastasis | 01/25 | 01/27 | | |
| Recruiting | N/A | 60 | Europe | Explorative biomarker study | University Hospital Heidelberg | Meningioma | 11/25 | 02/26 | | |
PUMA, NCT05237453: Pulmonary Magnetic Resonance-guided Online Adaptive Radiotherapy of Locally Advanced Non-Small Cell Lung Cancer |
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| Recruiting | N/A | 30 | Europe | Photons | University Hospital Heidelberg, University Hospital Tuebingen, Ludwig-Maximilians - University of Munich, German Cancer Research Center | Non-small Cell Lung Cancer | 03/26 | 03/27 | | |
| Körber, Stefan |
| Active, not recruiting | N/A | 68 | Europe | MR-guided Radiotherapy | University Hospital Heidelberg, Ludwig-Maximilians - University of Munich, University Hospital, Zürich | Prostate Cancer | 03/23 | 03/28 | | |
| Hörner-Rieber, Juliane |
| Recruiting | 2 | 92 | Europe | SBRT, oMRgRT, SOC chemotherapy | Ludwig-Maximilians - University of Munich, Heidelberg University, University of Zurich | Pancreatic Cancer | 12/23 | 05/24 | | |
MAGELLAN, NCT04925583: Magnetic Resonance Guided Adaptive Stereotactic Body Radiotherapy for Lung Tumors in Ultracentral Location |
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| Recruiting | 1 | 38 | Europe | Stereotactic body radiotherapy (SBRT) | University Hospital Heidelberg | Lung Cancer | 11/25 | 11/26 | | |
| Recruiting | N/A | 40 | Europe | MR-guided radiation | Juergen Debus | Cervical Cancer | 11/25 | 05/26 | | |
PUMA, NCT05237453: Pulmonary Magnetic Resonance-guided Online Adaptive Radiotherapy of Locally Advanced Non-Small Cell Lung Cancer |
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| Recruiting | N/A | 30 | Europe | Photons | University Hospital Heidelberg, University Hospital Tuebingen, Ludwig-Maximilians - University of Munich, German Cancer Research Center | Non-small Cell Lung Cancer | 03/26 | 03/27 | | |
