| Vergote, Ignace B |
INNOVATE-3, NCT03940196: Effect of Tumor Treating Fields (TTFields, 200 kHz) Concomitant With Weekly Paclitaxel for the Treatment of Recurrent Ovarian Cancer (ENGOT-ov50 / GOG-3029 / ) |
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| Completed | 3 | 540 | Europe, Canada, US, RoW | NovoTTF-100L(O), TTFields, Paclitaxel, Weekly Paclitaxel, Taxol | NovoCure Ltd. | Ovarian Cancer | 05/23 | 05/23 | | |
| Active, not recruiting | 2 | 160 | Europe | Olaparib, Lynparza, carboplatin + gemcitabine or carboplatin + paclitaxel or carboplatin + liposomal doxorubicin or liposomal doxorubicin 4-weekly or topotecan or paclitaxel weekly | Universitaire Ziekenhuizen Leuven, AstraZeneca | Ovarian Epithelial Cancer | 07/21 | 07/23 | | |
| Active, not recruiting | 2 | 48 | Europe | Atezolizumab, Doxorubicin | Universitaire Ziekenhuizen KU Leuven, Roche Pharma AG | Cervical Cancer | 09/25 | 09/25 | | |
NCT01763125: Establishment of a Tumor Bank for Blood Samples |
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| Recruiting | N/A | 10000 | Europe | Blood collection | Medical University of Vienna | Ovarian Neoplasms, Breast Neoplasms, Colorectal Neoplasms, Neoplasms of the Female Genitalia, Lung Neoplasms, Endocrine Gland Neoplasms | 12/26 | 12/26 | | |
| Wildiers, Hans |
| Active, not recruiting | 2 | 366 | Europe, RoW | Palbociclib, Docetaxel / cyclophosphamide, doxorubicin/cyclophosphamide, epirubicin/cyclophosphamide, paclitaxel | European Organisation for Research and Treatment of Cancer - EORTC, Pfizer, Swedish Association of Breast Oncologists, ETOP IBCSG Partners Foundation, German Adjuvant Breast Cancer Group, SOLTI Breast Cancer Research Group, UNICANCER, Gruppo Oncologico Italiano di Ricerca Clinica, Breast International Group | Breast Cancer Stage II, Breast Cancer Stage III | 06/26 | 09/32 | | |
IMAGE, NCT02176447: Age-related Changes in the Immune System and Their Impact on Elderly Breast Cancer |
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| Recruiting | N/A | 60 | Europe | | Universitaire Ziekenhuizen Leuven | Breast Cancer | 12/15 | | | |
NCT02258035: Isolation of Vitamin D Binding Protein Isoforms From Human Volunteers |
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| Active, not recruiting | N/A | 24 | Europe | Blood draw | Universitaire Ziekenhuizen KU Leuven | Vitamin D Deficiency | 12/16 | 12/25 | | |
RibOB, NCT03956654: A Phase IV Study to Collect Data on the Efficacy and Safety of RIBociclib in Older Women With Breastcancer |
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| Completed | N/A | 78 | Europe | Ribociclib, Kisqali | Universitaire Ziekenhuizen KU Leuven | Breast Cancer | 05/22 | 06/24 | | |
| Completed | N/A | 204 | Europe | CGA coordination by geriatric team including intensive patient coaching and follow-up | Universitaire Ziekenhuizen KU Leuven, Kom Op Tegen Kanker, Universitair Ziekenhuis Brussel | Geriatrics, Comprehensive Geriatric Assessment | 12/22 | 03/23 | | |
GerOnTe-TWOBE, NCT05423808: Geriatric and Oncological Evaluation With Technology for Holistic Healthcare Management for Older Multimorbid Patients. |
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| Withdrawn | N/A | 720 | Europe | Health Professional Consortium, Holis Dashboard - Holis Patient App | Universitaire Ziekenhuizen KU Leuven, University of Bordeaux, Diakonessenhuis, Utrecht, University of Milan, University College Dublin, Oslo University Hospital, International Society of Geriatric Oncology, Dublin City University, Universitair Ziekenhuis Brussel, General Hospital Groeninge, AZ Sint-Jan AV, Catharina Ziekenhuis Eindhoven, Reinier de Graaf Groep, KU Leuven | Geriatrics, Medical Oncology, Critical Pathways, Digital Technology | 08/24 | 08/24 | | |
| Desmet, Walter JR |
| Recruiting | N/A | 60 | Europe | Treatment with impella device. | Universitaire Ziekenhuizen KU Leuven | Shock, Cardiogenic | 01/24 | 01/24 | | |
| Dubois, Christophe LF |
| Active, not recruiting | N/A | 116 | Europe | | Universitaire Ziekenhuizen KU Leuven, AZ Delta, University Hospital, Antwerp | Aortic Stenosis, Coronary Artery Disease | 04/24 | 07/24 | | |
HighFLO, NCT04888247: Study - HighLife Trans-septal Mitral Valve Replacement (TSMVR) Feasibility Study of the Open Cell CLARITY Valve |
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| Recruiting | N/A | 30 | Europe, RoW | CLARITY | HighLife SAS | Mitral Regurgitation | 12/25 | 02/31 | | |
NCT04029363: Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk |
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| Recruiting | N/A | 120 | Europe, RoW | HighLife Transcatheter Mitral Valve Replacement | HighLife SAS, ICON plc | Mitral Regurgitation | 03/25 | 06/30 | | |
| Recruiting | N/A | 60 | Europe | Treatment with impella device. | Universitaire Ziekenhuizen KU Leuven | Shock, Cardiogenic | 01/24 | 01/24 | | |
| Active, not recruiting | N/A | 200 | Europe, RoW | Tendyne™ Mitral Valve System, Transcatheter Mitral Valve Implantation (TMVI) | Abbott Medical Devices | Mitral Valve Regurgitation | 05/25 | 05/29 | | |
| Recruiting | N/A | 400 | Europe | Tendyne Mitral Valve System | Klinikum der Universitaet Muenchen | Mitral Regurgitation | 12/26 | 12/27 | | |
| Delforge, Michel |
NCT05289492: Study of Novel Regimens in Relapsed or Refractory Multiple Myeloma |
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| Terminated | 1 | 16 | Europe, US | EOS884448, EOS-448, GSK4428859A, Belrestotug, Iberdomide, CC-220, Dexamethasone | iTeos Therapeutics, Bristol-Myers Squibb, GlaxoSmithKline, iTeos Belgium SA | Multiple Myeloma | 11/23 | 11/23 | | |
| Completed | 1 | 15 | Europe, US, RoW | Modakafusp alfa, TAK-573, Lenalidomide, Bortezomib, Carfilzomib, Daratumumab, Pomalidomide | Takeda, Takeda Development Center Americas, Inc. | Multiple Myeloma | 06/24 | 06/24 | | |
| Recruiting | N/A | 100 | Europe | Teclistamab, Tecvayli | Universitaire Ziekenhuizen KU Leuven, Janssen Pharmaceutica | Multiple Myeloma, Hematologic Diseases | 09/27 | 09/27 | | |
| Evenepoel, Pieter |
NCT01886950: Evolution of Bone Histomorphometry and Vascular Calcification Before and After Renal Transplantation |
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| Recruiting | N/A | 250 | Europe | | Universitaire Ziekenhuizen KU Leuven | Chronic Kidney Disease | 12/25 | 12/25 | | |
| Troosters, Thierry |
NCT04139200: Long-term Activity Coaching in Patients With COPD |
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| Completed | N/A | 150 | Europe | Type 1 physical activity tele coaching intervention, Type 2 physical activity tele coaching intervention | KU Leuven, University Ghent | COPD | 12/23 | 12/23 | | |
NCT04122768: Activity Coaching in Patients Post Lung Transplantation |
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| Completed | N/A | 108 | Europe | Multi-component physical activity tele coaching intervention, Light coaching intervention | KU Leuven | Lung Transplantation | 09/23 | 09/23 | | |
NCT05233137: Enhancing Muscle Function After Exacerbations of COPD to Limit Its Impact on Physical Activity Decline |
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| Active, not recruiting | N/A | 154 | Europe | PA coaching, Exercise training | KU Leuven, Research Foundation - Flanders (FWO: Fonds Wetenschappelijk Onderzoek) | COPD Exacerbation | 01/25 | 01/25 | | |
| Verleden, Geert |
NCT04122768: Activity Coaching in Patients Post Lung Transplantation |
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| Completed | N/A | 108 | Europe | Multi-component physical activity tele coaching intervention, Light coaching intervention | KU Leuven | Lung Transplantation | 09/23 | 09/23 | | |
| Kuypers, Dirk R |
| Active, not recruiting | 4 | 374 | Europe | low dose tacrolimus in combination with everolimus, standard dose tacrolimus with mycophenolate mofetil | University Medical Center Groningen, Radboud University Medical Center, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Amsterdam UMC, location VUmc, UMC Utrecht, Leiden University Medical Center, Erasmus Medical Center, Universitaire Ziekenhuizen KU Leuven | Renal Transplant Recipients, Elderly Patients, Immunosuppression | 06/25 | 12/26 | | |
Shamrock, NCT06503731: A Study to Evaluate the Safety and Tolerability of Efgartigimod PH20 SC Given by Prefilled Syringe in Kidney Transplant Recipients with Antibody-Mediated Rejection (AMR) |
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| Recruiting | 2 | 30 | Europe, Canada, US | Efgartigimod PH20 SC - prefilled syringe, Placebo PH20 SC - prefilled syringe | argenx | Antibody-mediated Rejection | 09/27 | 09/27 | | |
VARVARA, NCT05907096: ARGX-117 in Deceased Donor Kidney Transplant Recipients At Risk for Delayed Graft Function |
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| Recruiting | 2 | 102 | Europe, Canada, US, RoW | ARGX-117, Placebo | argenx | Delayed Graft Function | 04/26 | 12/26 | | |
| Active, not recruiting | 1/2 | 22 | Europe | TX200-TR101, CAR-Tregs | Sangamo Therapeutics, Sangamo Therapeutics France SAS | Kidney Transplant Rejection, End Stage Renal Disease | 07/24 | 10/25 | | |
| Claes, kathleen |
NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes) |
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| Recruiting | 3 | 10000 | Europe, Canada, US, RoW | Retatrutide, LY3437943, Placebo | Eli Lilly and Company | Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD) | 02/29 | 02/29 | | |
| Stas, Marguerite |
| Active, not recruiting | N/A | 296 | Europe | | European Organisation for Research and Treatment of Cancer - EORTC | Cutaneous Melanoma | 12/23 | 12/31 | | |
| Topal, Baki |
MIMIPAC, NCT04156087: Progression-free Survival After MWA Plus Durvalumab and Tremelimumab for Unresectable Locally Advanced Pancreatic Cancer |
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| Completed | 2 | 12 | Europe | Durvalumab 50 MG/ML, MEDI4736, IMFINZI, Tremelimumab, Gemcitabine, Gemzar, Minimally Invasive Surgical Microwave Ablation (MIS-MWA) | Baki Topal, AstraZeneca | Pancreatic Cancer Non-resectable | 01/24 | 01/24 | | |
| Meerleer, Gert De |
MEDCARE, NCT06585007: Metastasis-directed Therapy in Oligoprogressive Castration-refractory Prostate Cancer |
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| Recruiting | 3 | 246 | Europe | Radiotherapy, metastasectomy | Universitaire Ziekenhuizen KU Leuven | Castration-resistant Prostate Cancer, Oligoprogressive | 01/29 | 01/29 | | |
| Recruiting | 3 | 873 | Europe | Radiotherapy (SBRT) and/or surgery (metastasectomy), Androgen deprivation therapy, Androgen receptor targeted therapy | Universitaire Ziekenhuizen KU Leuven | Prostate Cancer, Prostate Cancer Recurrent, Prostate Cancer Metastatic, Metastatic Cancer, Oligometastatic Disease, Oligometastasis, Hormone Sensitive Prostate Cancer | 04/27 | 04/32 | | |
| Recruiting | 2/3 | 394 | Europe | Triptoreline | Universitaire Ziekenhuizen KU Leuven, Ipsen | Prostate Cancer | 02/26 | 02/31 | | |
STOMP, NCT01558427: Non-systemic Treatment for Patients With Low-volume Metastatic Prostate Cancer |
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| Completed | 2 | 62 | Europe | Surveillance, Salvage treatment | University Hospital, Ghent | Prostate Cancer | 08/18 | 08/23 | | |
NCT03079323: Trial to Investigate the Benefit of Elective Para-Aortic Radiotherapy (PART) for pN1 Prostate Cancer |
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| Recruiting | 2 | 137 | Europe | PART-trial | Universitaire Ziekenhuizen KU Leuven | Prostate Cancer | 02/25 | 02/25 | | |
| Active, not recruiting | N/A | 18 | Europe | Radiotherapy (SBRT) and/or surgery (metastasectomy) | Universitaire Ziekenhuizen KU Leuven | Castration-resistant Prostate Cancer | 07/23 | 01/30 | | |
| Recruiting | N/A | 246 | Europe | SBRT | Universitaire Ziekenhuizen KU Leuven | Prostate Cancer, Radiotherapy, SBRT | 04/27 | 04/32 | | |
| Maertens, Johan |
SAFE, NCT05926063: Stopping Antibiotics After 3 Days for the Treatment of High-risk FEbrile Neutropenia |
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| Recruiting | 4 | 410 | Europe | Comparison short vs extended EBAT treatment group | Universitaire Ziekenhuizen KU Leuven, University Hospital, Ghent, Universitair Ziekenhuis Brussel, University Hospital, Antwerp, AZ Sint-Jan AV, Centre Hospitalier Universitaire de Liege, Cliniques universitaires Saint-Luc- Université Catholique de Louvain | Neutropenia, Febrile | 07/26 | 07/26 | | |
| Recruiting | 3 | 149 | Europe | Multivirus (CMV, EBV, AdV)-specific T cells | Prof. Tobias Feuchtinger, European Commission, Simbec-Orion Group Ltd, Merthyr Tydfil, UK, Miltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany, Leiden University Medical Center, LUMC, Leiden, The Netherlands, Centre Hospitalier Universitaire de Nancy, CHU, Vandoeuvre-Lès-Nancy, France, Ghent University Hospital, UZG, Ghent, Belgium, Ospedale Pediatrico Bambino Gesù, OPBG, Rome, Italy, Newcastle University, UNEW, Newcastle, UK, Vall d'Hebron Institute of Oncology (VHIO) and Banc de Sang I Teixits (BST), Barcelona, Spain | AdV Infection, EBV Infection, CMV Infection, Stem Cell Transplant Complications | 06/24 | 12/24 | | |
| Recruiting | 3 | 225 | Europe, Canada, Japan, US, RoW | Olorofim, Olorofim (F901318), AmBisome®, AmBisome® (liposomal amphotericin B) | F2G Biotech GmbH, Iqvia Pty Ltd, Shionogi | Invasive Aspergillosis | 09/25 | 11/26 | | |
HOVON 156 AML, NCT04027309 / 2018-000624-33: A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy |
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| Active, not recruiting | 3 | 777 | Europe, RoW | Gilteritinib, ASP2215, Midostaurin, Rydapt | Stichting Hemato-Oncologie voor Volwassenen Nederland, Deutsch-Österreichische Studiengruppe Akute Myeloische Leukämie (AMLSG), Astellas Pharma Global Development, Inc. | Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2 | 10/25 | 06/33 | | |
| Terminated | 3 | 66 | Europe | Azole, Voriconazole, isavuconazole, posaconazole, Anidulafungin, Ecalta | Erasmus Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development, Stichting Hemato-Oncologie voor Volwassenen Nederland | Invasive Aspergillosis | 05/24 | 05/24 | | |
| Completed | 2 | 203 | Europe, US, RoW | Olorofim, F901318 | F2G Biotech GmbH, Iqvia Pty Ltd | Invasive Fungal Infections | 02/23 | 02/23 | | |
| Terminated | 2 | 22 | Europe, Canada, US, RoW | SCY-078, Ibrexafungerp, Voriconazole, Oral Placebo Tablets, SCY-078 matching Placebo | Scynexis, Inc., SCYNEXIS, Inc. | Invasive Pulmonary Aspergillosis | 03/23 | 03/23 | | |
NCT00603330: Mesenchymal Stem Cell Infusion as Treatment for Steroid-Resistant Acute Graft Versus Host Disease (GVHD) or Poor Graft Function |
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| Recruiting | 2 | 100 | Europe | Mesenchymal stem cells | University of Liege, KU Leuven, Maastricht University Medical Center, Ziekenhuis Netwerk Antwerpen (ZNA), University Hospital, Antwerp, University Hospital, Ghent, AZ-VUB, AZ Sint-Jan AV, Cliniques universitaires Saint-Luc- Université Catholique de Louvain, University Hospital of Mont-Godinne, Jolimont Hospital Haine Saint Paul, Queen Fabiola Children's University Hospital | Graft-versus-host Disease, Poor Graft Function, Low Donor T-cell Chimerism | 08/24 | 08/24 | | |
NCT03852407: Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy Versus Flu-Mel-ATG Reduced-intensity Conditioning |
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| Recruiting | 2 | 114 | Europe | Thymoglobulin, ATG, Melphalan, alkeran, Fludarabine, Cyclophosphamid, PTCy | University of Liege, Belgian Hematological Society | Acute Myeloid Leukemia in Remission, Myelodysplastic Syndromes, Chronic Myeloid Leukemia in Remission, Myeloproliferative Syndrome, Myeloproliferative Disorder, Acute Lymphoid Leukemia in Remission, Multiple Myeloma, Chronic Lymphoid Leukemia, Non Hodgkin Lymphoma, Hodgkin Lymphoma | 11/33 | 11/38 | | |
| Recruiting | 1/2 | 70 | Europe, Canada, Japan, US, RoW | DSP-5336 | Sumitomo Pharma America, Inc. | Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Acute | 01/25 | 02/25 | | |
CYCLE-1, NCT04167696: Study in Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Patients to Determine the Recommended Dose of CYAD-02 |
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| Recruiting | 1 | 27 | Europe, US | CYAD-02, ENDOXAN, cyclophosphamide, Fludara, fludarabine | Celyad Oncology SA | Acute Myeloid Leukemia, Myelodysplastic Syndrome | 12/21 | 02/35 | | |
BYON4413.001, NCT06359002: Safety, Pharmacokinetics, and Preliminary Efficacy of BYON4413 in Acute Myeloid Leukemia and Myelodysplastic Neoplasms. |
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| Recruiting | 1 | 100 | Europe | BYON4413 | Byondis B.V. | Relapsed / Refractory AML, Relapsed / Refractory MDS | 12/26 | 03/27 | | |
| Recruiting | N/A | 343 | Europe, RoW | Questionnaire | Gruppo Italiano Malattie EMatologiche dell'Adulto, European Organisation for Research and Treatment of Cancer - EORTC | Acute Myeloid Leukemia | 06/21 | 12/22 | | |
| Recruiting | N/A | 320 | Europe | Posaconazole, Noxafil, Fluconazole, Diflucan | Bochud Pierre-Yves, Swiss National Science Foundation | Candidiasis, Fungal Infection, Acute Myeloid Leukemia, Genetic Predisposition, Aspergillosis | 11/25 | 11/25 | | |
| Rutgeerts, Paul |
NCT01882205: Comparison Between Chromoendoscopy and Virtual Chromoendoscopy (NBI, I-scan, FICE) for Detection of Neoplasia in Long Standing Ulcerative Colitis |
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| Recruiting | N/A | 402 | Europe, Canada | Virtual chromoendoscopy, Narrow band Imaging (NBI), Fujinon Intelligent Color Enhancement, I-scan, Chromoendoscopy | Universitaire Ziekenhuizen KU Leuven, H.-Hartziekenhuis Roeselare-Menen VZW, Belgium., McGill University, Maastricht University Medical Center, Copenhagen University Hospital at Herlev | Ulcerative Colitis | 12/18 | 11/27 | | |
| Pirenne, Jacques |
NCT05276037: Value of Negative 18FDG PET/CT in Milan Out, Up-to-seven in, HCC Transplant Candidates |
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| Recruiting | N/A | 350 | Europe | Liver transplantation | University of Liege, University Hospital, Ghent, Free University of Brussels, University Hospital, Antwerp, Universitaire Ziekenhuizen Leuven, Cliniques universitaires Saint-Luc- Université Catholique de Louvain | Hepatocellular Carcinoma | 01/25 | 01/29 | | |
| Adriaenssens, Tom |
NCT04591938: FANTOM ENCORE Sirolimus-eluting Bioresorbable Scaffold for Treatment of De-novo CAD: the ENCORE-I Study |
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| Recruiting | N/A | 50 | Europe | Fantom Encore Bioresorbable scaffold implantation | Joost Daemen, Horizon 2020 - European Commission, REVA Medical, Inc. | Percutaneous Coronary Intervention, Myocardial Revascularization, Tomography, Optical Coherence | 06/21 | 12/25 | | |
RESTO, NCT04268875: Morphological Parameters of In-stent RESTenosis Assessed and Identified by OCT |
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| Completed | N/A | 307 | Europe | Optical Coherence Tomography (OCT) | University Hospital, Clermont-Ferrand, Abbott, Corelab ISIT | In-stent Restenosis | 12/22 | 12/22 | | |
EUROSHOCK, NCT03813134: Testing the Value of Novel Strategy and Its Cost Efficacy in Order to Improve the Poor Outcomes in Cardiogenic Shock |
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| Recruiting | N/A | 428 | Europe | Percutaneous coronary intervention (PCI), Pharmacological Support, VA-ECMO, Veno-Arterial Extra Corporeal Membrane Oxygenation. | University of Leicester, European Commission, University of Glasgow, KU Leuven, University of East Anglia, Deutsches Herzzentrum Muenchen, A.O. Ospedale Papa Giovanni XXIII, Chalice Medical Ltd, Ludwig-Maximilians - University of Munich, University of Tromso, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Paula Stradina Liniska Universitates, Accelopment AG, Universiteit Antwerpen, Cardiovascular European Research Centre (CERC) | Cardiogenic Shock | 03/23 | 02/24 | | |
| Recruiting | N/A | 60 | Europe | Treatment with impella device. | Universitaire Ziekenhuizen KU Leuven | Shock, Cardiogenic | 01/24 | 01/24 | | |
| Recruiting | N/A | 650 | Europe | Coronary Function Test | University Hospital, Antwerp | Coronary Microvascular Dysfunction, Coronary Artery Vasospasm | 12/25 | 12/26 | | |
| Recruiting | N/A | 500 | Europe | RAP TAVI | AZ Sint-Jan AV | Aortic Valve Stenosis | 06/24 | 06/24 | | |
| casteels, kristina m |
NCT06452654: Anti-viral Action Against Type 1 Diabetes Autoimmunity |
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| Recruiting | 4 | 2252 | Europe | Comirnaty Injectable Product, Comirnaty 3µg/dose for children for 6 month - 4 years, Sodium Chloride 0.9% Inj, Solution for Injection | Technical University of Munich, Helmholtz Zentrum München, University Hospital Carl Gustav Carus, Kinderkrankenhaus auf der Bult, Skane University Hospital, Universitaire Ziekenhuizen KU Leuven, Newcastle-upon-Tyne Hospitals NHS Trust, Cambridge University Hospitals NHS Foundation Trust, Birmingham Women's and Children's NHS Foundation Trust | Diabetes Mellitus, Type 1 | 10/27 | 10/27 | | |
NCT06502990: Open-label Study to Evaluate Metreleptin in Children Under 6 Years of Age With Generalised Lipodystrophy |
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| Recruiting | 3 | 15 | Europe | Metreleptin | Amryt Pharma | Generalized Lipodystrophy | 09/26 | 09/26 | | |
| Recruiting | N/A | 70 | Europe | | Universitaire Ziekenhuizen KU Leuven | Peripheral Artery Tonometry, Diabetes, Children, Obesity | 06/25 | 06/25 | | |
| Active, not recruiting | N/A | 232 | Europe | MetaSAMP | University Ghent, Universitaire Ziekenhuizen KU Leuven, Universitair Ziekenhuis Brussel, Algemeen Ziekenhuis Maria Middelares, AZ Jan Palfijn Gent, AZ Sint-Lucas Gent, University Hospital, Antwerp, AZ Alma, AZ Sint-Jan AV | Metabolic Disease, Obesity, Infant | 03/22 | 12/26 | | |
| Recruiting | N/A | 6000 | Europe | | University of Cambridge, Innovative Medicines Initiative, Juvenile Diabetes Research Foundation, The Leona M. and Harry B. Helmsley Charitable Trust | Type 1 Diabetes Mellitus | 10/22 | 10/22 | | |
COMBINE1, NCT06567158: The Impact of a Moderate Carbohydrate Diet in Children With Type 1 Diabetes on Hybrid Closed-loop Therapy |
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| Recruiting | N/A | 28 | Europe | Moderate carbohydrate diet, Traditional diet | Universitaire Ziekenhuizen KU Leuven | Diabetes Mellitus, Type 1 | 12/25 | 12/25 | | |
| Completed | N/A | 49 | Europe | Dexcom G6 Continuous Glucose Monitoring, MEDISAFE WITH External Insulin Pump, Diabeloop Software (Model predictive control), Declaration of meals, No declaration of meals, Remote monitoring (Telemedicine) | Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète | Closed Loop, Diabetes Mellitus, Type 1, Adolescents (12 to 17 Years Old) | 02/24 | 05/24 | | |
NCT05777330: Continuous Monitoring of Glycemic Variability to Predict Dys- and Hyperglycemia in Asymptomatic Type 1 Diabetes |
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| Recruiting | N/A | 75 | Europe | Oral glucose tolerance test (OGTT), OGTT, Hyperglycemic clamp test, clamp, Continuous glucose monitoring, Dexcom G6, CGM | Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Juvenile Diabetes Research Foundation | Type1 Diabetes Mellitus | 04/26 | 04/27 | | |
SINT1A, NCT04769037: Supplementation With B. Infantis for Mitigation of Type 1 Diabetes Autoimmunity |
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| Active, not recruiting | N/A | 1149 | Europe | B. infantis, Placebo | Helmholtz Zentrum München, Technical University of Munich, Kinderkrankenhaus auf der Bult, University Hospital Carl Gustav Carus, Skane University Hospital, Universitaire Ziekenhuizen KU Leuven, Medical University of Warsaw, Cambridge Biomedical Campus, Cambridge, UK, Royal Victoria Infirmary, Newcastle upon Tyne, UK | Diabetes Mellitus, Type 1 | 10/27 | 10/27 | | |
| Chen, Delphine L |
NCT04777071: An Investigational Scan (68Ga-PSMA-11 PET) for the Imaging of Prostate Cancer |
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| Recruiting | 2 | 213 | US | Computed Tomography, CAT, CAT Scan, Computerized Axial Tomography, Computerized Tomography, CT, CT Scan, tomography, Gallium Ga 68 Gozetotide, (68)Ga labeled Glu-NH-CO-NH-Lys(Ahx)-HBED-CC, (68)Ga-labeled Glu-urea-Lys(Ahx)-HBED-CC, (68)Ga-PSMA Ligand Glu-urea-Lys(Ahx)-HBED-CC, (68)Gallium-PSMA Ligand Glu-urea-Lys(Ahx)-HBED-CC, (68Ga)Glu-urea-Lys(Ahx)-HBED-CC, 68Ga-DKFZ-PSMA-11, 68Ga-HBED-CC-PSMA, 68Ga-labeled Glu-NH-CO-NH-Lys(Ahx)-HBED-CC, 68Ga-PSMA, 68Ga-PSMA-11, 68Ga-PSMA-HBED-CC, [68Ga] Prostate-specific Membrane Antigen 11, [68Ga]GaPSMA-11, Ga PSMA, Ga-68 labeled DKFZ-PSMA-11, Ga-68 labeled PSMA-11, GA-68 PSMA-11, Gallium Ga 68 PSMA-11, Gallium Ga 68-labeled PSMA-11, GALLIUM GA-68 GOZETOTIDE, Gallium-68 PSMA, Gallium-68 PSMA Ligand Glu-urea-Lys(Ahx)-HBED-CC, GaPSMA, PSMA-HBED-CC GA-68, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, Magnetic Resonance Imaging, MRI, MR Imaging, NMRI, nuclear magnetic resonance imaging, Bone Scan | University of Washington | Biochemically Recurrent Prostate Carcinoma, Castration-Resistant Prostate Carcinoma, Prostate Adenocarcinoma, Stage IV Prostate Cancer AJCC v8 | 12/25 | 03/28 | | |
| Active, not recruiting | 2 | 70 | Europe, US, RoW | zirconium Zr 89 crefmirlimab berdoxam, 89Zr-Df-crefmirlimab, 89Zr-Df-IAB22M2C | ImaginAb, Inc. | Melanoma, Merkel Cell Carcinoma, Unspecified, Renal Cell Carcinoma, Non Small Cell Lung Cancer | 07/25 | 07/25 | | |
NCT06129422: Safety, Tolerability, Pharmacokinetics, Radiation Dosimetry, and PET Imaging Properties of 89Zr-labeled hNd2 (NMK89) in Patients With Pancreatic Cancer |
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| Recruiting | 1 | 10 | US | NMK89 | Nihon Medi-Physics Co., Ltd. | Pancreatic Cancer | 03/25 | 03/25 | | |
NCT06147037: A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients with Advanced Solid Tumours |
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| Recruiting | 1 | 110 | Canada, US | FPI-2053, [111In]-FPI-2107, [225Ac]-FPI-2068 | Fusion Pharmaceuticals Inc., AstraZeneca | Advanced Solid Tumor, Metastatic Colorectal Carcinoma, Head and Neck Squamous Cell Carcinoma, Non-small Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma | 12/26 | 12/27 | | |
| Deprest, Jan A |
NCT03788122: Fetal Surgery Interview Study: Parental Perceptions of Fetal Surgery |
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| Recruiting | N/A | 40 | Europe | In-depth interview | Universitaire Ziekenhuizen KU Leuven, University College, London, Wellcome Trust | Fetal Surgery, Myelomeningocele, Congenital Diaphragmatic Hernia | 11/25 | 02/26 | | |
| Recruiting | N/A | 20 | Europe | | Universitaire Ziekenhuizen KU Leuven | Obstetric Labor | 03/25 | 12/25 | | |
| Recruiting | N/A | 320 | Europe | Questionnaire, Pelvic floor ultrasound, Transperineal ultrasound, Pelvic floor sonography | Universitaire Ziekenhuizen KU Leuven | Pelvic Floor Disorders, Obstetric Trauma, Urinary Incontinence, Anal Incontinence, Pelvic Organ Prolapse, Pelvic Pain, Sexual Dysfunction, Constipation, Anal Sphincter Injury | 09/24 | 09/25 | | |
VELSUI, NCT04643353: Use of Non-ablative Vaginal Erbium YAG Laser for the Treatment of Stress Urinary Incontinence. |
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| Completed | N/A | 60 | Europe | Non-ablative vaginal Erbium YAG laser treatment, PFE | Universitaire Ziekenhuizen KU Leuven | Urinary Incontinence,Stress | 12/23 | 12/23 | | |
LASI, NCT05713435: Use of Fractional CO2 Laser Versus Erbium:YAG Laser for the Treatment of GSM in Patients Using Aromatase Inhibitors |
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| Recruiting | N/A | 162 | Europe | intravaginal laser | Universitaire Ziekenhuizen KU Leuven | Genitourinary Syndrome of Menopause | 12/24 | 12/25 | | |
| Recruiting | N/A | 25 | Europe | Fetoscopic Endoluminal Tracheal Occlusion with the Smart-TO Balloon, FETO | Universitaire Ziekenhuizen Leuven | Congenital Diaphragmatic Hernia | 08/26 | 11/26 | | |
| Verbeke, Kristin |
| Recruiting | 2/3 | 60 | Europe | Rifaximin, Targaxan, Placebo | Universitaire Ziekenhuizen KU Leuven, European Research Council (ERC) | Healthy Volunteers, Stress, Fear | 07/25 | 07/25 | | |
| Completed | N/A | 55 | Europe | Wire-cut cookie | KU Leuven | Postprandial Glycemic Responses | 11/23 | 11/23 | | |
| Not yet recruiting | N/A | 72 | NA | Processing of wheat | KU Leuven | Iron Absorption, Zinc Absorption | 05/24 | 10/24 | | |
SUPPRESS, NCT04788069: Effect of Sourdough Breads Consumption on Postprandial Responses, Satiety and Food Intake at Subsequent Meal |
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| Completed | N/A | 43 | Europe | Wholemeal bread, Sourdough bread, Bread with sourdough | KU Leuven | Energy Intake, Appetite Regulation | 02/24 | 02/24 | | |
Sistine, NCT06082726: The Systemic Concentration of Short-Chain Fatty Acids After Delivery in the Small and Large Intestine of Healthy Volunteers |
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| Recruiting | N/A | 13 | Europe | SCFA | KU Leuven | Systemic Availability, Intestinal Absorption, Metabolism, Short-chain Fatty Acids | 05/24 | 05/24 | | |
INFLAMES, NCT06620679: Mapping the Effect of (neuro)inflammation on Stress Sensitivity in the Brain of Healthy Men |
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| Recruiting | N/A | 20 | Europe | Lipopolysaccharide (LPS), Placebo | Universitaire Ziekenhuizen KU Leuven | Inflammation, Stress, Healthy Volunteer | 12/26 | 12/26 | | |
| Recruiting | N/A | 48 | Europe | Prebiotic, L-Tryptophan, Placebo | KU Leuven | Stress, Psychological | 07/24 | 07/24 | | |
SOBER, NCT05590611: Impact of Sourdough Bread Consumption on Long-term Energy Intake: A Pilot Study of Feasibility |
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| Recruiting | N/A | 100 | Europe | Dietary Intervention with Brown Bread, Dietary Intervention with Sourdough Bread | KU Leuven | Appetite Regulation, Energy Intake, Body Weight Changes, Eating Behavior, Overweight and Obesity | 09/24 | 09/24 | | |
| Not yet recruiting | N/A | 32 | Europe | Short-Chain Fatty Acids, Placebo | Universitaire Ziekenhuizen KU Leuven | Stress, Healthy Volunteers | 12/26 | 12/26 | | |
NCT06686888: The Impact of Short-Chain Fatty Acids on Gut Hormone Release After Delivery in the Small and Large Intestine of Healthy Volunteers |
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| Recruiting | N/A | 27 | Europe | SCFA, microcristalline cellulose | KU Leuven | Satiety Hormones, Short-chain Fatty Acids, Satiety and Appetite, Intestinal Absorption, Metabolism, Glucose Homeostasis | 01/25 | 01/25 | | |
SPAR, NCT06015867: Effect of Sourdough Bread Consumption on Postprandial Responses, Appetite Regulation and Energy Intake |
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| Completed | N/A | 47 | Europe | Dietary Intervention with Wholemeal Bread with Yeast, Dietary Intervention with Wholemeal Sourdough Bread | KU Leuven | Appetite, Satiety, Energy Intake, Glucose Response, Insulin Response, Gastric Emptying | 04/24 | 04/24 | | |
| Wuyts, Wim |
| Active, not recruiting | 3 | 160 | Europe, Canada, Japan, US, RoW | Molgramostim, Recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF), Placebo | Savara Inc., Savara ApS, | Autoimmune Pulmonary Alveolar Proteinosis | 11/23 | 11/24 | | |
| Active, not recruiting | 3 | 597 | Europe, RoW | Placebo, Inhaled Treprostinil, Tyvaso, Treprostinil Ultrasonic Nebulizer | United Therapeutics | Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease | 07/25 | 07/25 | | |
BLISSc-ILD, NCT05878717: A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease |
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| Recruiting | 2/3 | 300 | Europe, Japan, US, RoW | Belimumab, BENLYSTA™, GSK1550188, LymphoStat-B™, BENLYSTATM, GSK1550188, LymphoStat-B™, Placebo | GlaxoSmithKline | Systemic Sclerosis Associated Interstitial Lung Disease, Scleroderma, Systemic | 07/27 | 07/27 | | |
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| Completed | 2 | 81 | Europe, Canada, US, RoW | Garadacimab, Factor XIIa antagonist monoclonal antibody, CSL312, Placebo | CSL Behring | Idiopathic Pulmonary Fibrosis | 01/24 | 01/24 | | |
| Active, not recruiting | 2 | 48 | Europe, RoW | RXC007, Placebo | Redx Pharma Plc, Simbec-Orion Group | IPF, Fibrosis | 06/24 | 01/25 | | |
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I-FILE, NCT04304898: An International Patient-led Registry in Fibrotic Interstitial Lung Diseases Using eHealth Technology |
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| Recruiting | N/A | 700 | Europe | Home spirometry | Erasmus Medical Center | Pulmonary Fibrosis | 07/25 | 07/26 | | |
| Neven, Patrick |
EMBER-3, NCT04975308 / 2021-000079-35: A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer |
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| Active, not recruiting | 3 | 866 | Europe, Japan, US, RoW | Imlunestrant, LY3484356, Exemestane, Fulvestrant, Abemaciclib, LY2835219 | Eli Lilly and Company, Eli Lilly and Company | Breast Neoplasms, Neoplasm Metastasis | 06/24 | 08/27 | | |
ELAINE 3, NCT05696626: Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation |
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| Recruiting | 3 | 500 | Europe, Canada, US, RoW | Lasofoxifene in combination with abemaciclib, Fulvestrant in combination with abemaciclib | Sermonix Pharmaceuticals Inc. | Metastatic Breast Cancer | 04/27 | 04/28 | | |
EMBER-4, NCT05514054: A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer |
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| Recruiting | 3 | 6000 | Europe, Canada, Japan, US, RoW | Imlunestrant, LY3484356, Tamoxifen, Anastrozole, Letrozole, Exemestane | Eli Lilly and Company | Breast Neoplasms | 10/27 | 03/32 | | |
