Center Inselspital Bern
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 33 Trials 
120 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Windecker, Stephan
MATRIX-2, NCT05955365 / 2023-509717-36-00: Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation

Recruiting
4
3010
Europe
P2Y12 inhibitor, Aspirin, DOAC
Insel Gruppe AG, University Hospital Bern, Sahajanand Medical Technologies Limited
AF patients who have undergone successful PCI
12/27
06/28
SURTAVI, NCT01586910: Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement ().

Active, not recruiting
N/A
1746
Europe, Canada, US
Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI), Surgical Aortic Valve Replacement (SAVR), Medtronic CoreValve® Evolut R System Transcatheter Aortic Valve Implantation (TAVI)
Medtronic Cardiovascular
Severe Aortic Stenosis
07/18
11/26
NCT03699345: CENTERA PMCF: Post-Market Follow-up of the CENTERA Transcatheter Heart Valve System

Completed
N/A
87
Europe
Transcatheter Aortic Valve Replacement (TAVR)
Edwards Lifesciences
Aortic Valve Stenosis
08/19
08/24
NCT03168776: PIONEER III Trial to Assess Safety and Efficacy of the BuMA Supreme™ Drug Coated Coronary Stent in Patients With Coronary Disease

Completed
N/A
1629
Europe, Canada, Japan, US
BuMA Supreme DES, Xience or Promus DES
Sino Medical Sciences Technology Inc., Nova Vascular LLC
Coronary Artery Disease
10/20
10/24
Amulet IDE, NCT02879448: AMPLATZER™ Amulet™ LAA Occluder Trial

Completed
N/A
1878
Europe, Canada, US, RoW
Amulet Left Atrial Appendage Occluder, WATCHMAN Left Atrial Appendage Closure
Abbott Medical Devices
Stroke
12/20
05/24
EXPLORE MR, NCT04098328: Early Feasibility EXperience of Posterior Leaflet RestOration to REduce Mitral Regurgitation

Terminated
N/A
2
Europe
Polares Medical SA
Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Insufficiency
02/23
02/23
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Active, not recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
06/26
06/31
NCT01368250: SwissTAVI Registry

Recruiting
N/A
20000
Europe
Transcatheter Aortic Valve Implantation
Insel Gruppe AG, University Hospital Bern
Aortic Valve Disease Mixed
05/25
05/25
NCT02241291: CARDIOBASE Bern PCI Registry

Recruiting
N/A
10000
Europe
Percutaneous coronary intervention
University Hospital Inselspital, Berne
Myocardial Ischemia
07/25
07/25
NCT04221490: 2019-06 TRISCEND Study

Active, not recruiting
N/A
228
Europe, Canada, US
Transcatheter Tricuspid Valve Replacement, Edwards EVOQUE Tricuspid Valve Replacement System
Edwards Lifesciences
Tricuspid Valve Regurgitation, Heart Valve Diseases, Cardiovascular Diseases
01/24
01/29
NCT05149755: Evolut™ EXPAND TAVR II Pivotal Trial

Active, not recruiting
N/A
650
Europe, Canada, Japan, US, RoW
Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT)
Medtronic Cardiovascular
Moderate Aortic Valve Stenosis
09/27
12/34
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial

Recruiting
N/A
400
Europe
Medtronic Intrepid? TMVR TF System
Medtronic Cardiovascular
Mitral Regurgitation
08/29
12/38
Saw, Jacqueline
SCAD-ALIGN, NCT07683923: Spontaneous Coronary Artery Dissection - AntipLatelet Therapy Intensity in Guided coNservative Management () Trial

Not yet recruiting
4
3518
Europe, Canada
Acetylsalicylic acid ASA, ASA plus Clopidogrel
Universit?tsklinikum Hamburg-Eppendorf, National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK, Gesellschaft f?r Therapieforschung mbH, Deutsches Zentrum f?r Herz-Kreislauf-Forschung (DZHK), Cardio-CARE AG, Davos
SCAD, ACS (Acute Coronary Syndrome)
02/33
02/33
NCT04180605: Computational Simulation to Plan for Percutaneous Left Atrial Appendage Closure

Recruiting
N/A
200
Europe, Canada
Additional support for preoperative planning of LAA closure procedures, Left atrial appendage closure
Rigshospitalet, Denmark, Feops, Abbott
Atrial Fibrillation, Stroke Prevention
12/21
12/22
NCT04000607: Exploratory Study of the Edwards APTURE Transcatheter Shunt System (ALT-FLOW Canada)

Active, not recruiting
N/A
45
Canada
APTURE transcatheter shunt
Edwards Lifesciences
Heart Failure
11/23
11/28
ABT-CIP-10523, NCT06707688: Abbott Medical - VERITAS Study

Active, not recruiting
N/A
458
Europe, Canada, US
Amulet? 2 Left Atrial Appendage (LAA) Occluder
Abbott Medical Devices
Atrial Fibrillation (AF), Stoke
11/25
09/27
CATALYST, NCT04226547: Amplatzer Amulet LAAO vs. NOAC

Active, not recruiting
N/A
2650
Europe, Canada, Japan, US, RoW
Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC
Abbott Medical Devices
Atrial Fibrillation, Stroke, Bleeding
01/29
04/31
ASAP-TOO, NCT02928497: Assessment of the WATCHMAN? Device in Patients Unsuitable for Oral Anticoagulation

Terminated
N/A
481
Europe, Canada, US, RoW
WATCHMAN LAAC Device Implant, Single Antiplatelet Therapy or No Therapy (Control)
Boston Scientific Corporation
Stroke
09/25
09/25
NCT04906356: Canadian SCAD Study

Recruiting
N/A
3000
Canada
Genetic sub-study
Cardiology Research UBC, John GB Mancini, MD, Karin Humphries, DSc
Spontaneous Coronary Artery Dissection, SCAD, Fibromuscular Dysplasia
12/33
12/33
Rosenbloom, Michael H
NCT06538116: A Study of Mevidalen (LY3154207) in Participants With Alzheimer's Disease

Completed
2
304
Japan, US
Mevidalen, LY3154207, Placebo
Eli Lilly and Company
Alzheimer Disease
05/26
05/26
NCT07094516: A Clinical Trial to Learn About the Effects of VHB937 in People With Early Alzheimer's Disease

Recruiting
2
407
Europe, Canada, Japan, US, RoW
VHB937, Placebo
Novartis Pharmaceuticals
Alzheimer's Disease
09/28
12/30
PTP, NCT07173803: The Progressive Supranuclear Palsy Clinical Trial Platform

Recruiting
2
440
US
AADvac1, LM11A-31
Adam Boxer, National Institute on Aging (NIA), Alzheimer's Therapeutic Research Institute, University of Southern California, Massachusetts General Hospital, University of California, San Diego, Alzheimer's Clinical Trials Consortium
Progressive Supranuclear Palsy(PSP)
09/30
09/30
NCT04773041: Dementia With Lewy Bodies - Infinitome

Completed
N/A
91
US
Infinitome
HealthPartners Institute
Dementia With Lewy Bodies
02/23
06/23
POCD, NCT04267328: Post-Operative Cognitive Dysfunction in Normal Aging Patients Undergoing Elective Orthopedic Surgery

Completed
N/A
47
US
Elective Orthopedic Surgery
HealthPartners Institute
Post Operative Cognitive Dysfunction
05/23
06/23
NCT05292222: Transmagnetic Stimulation Pilot in Early Stage Alzheimer's Disease

Completed
N/A
15
US
Intermittent theta burst stimulation, Transmagnetic stimulation, MagVenture
HealthPartners Institute
Alzheimer Disease
11/23
11/23
TMS in PPA, NCT05860647: Transmagnetic Stimulation Pilot in Primary Progressive Aphasia

Completed
N/A
3
US
Intermittent theta burst stimulation, Transmagnetic stimulation, MagVenture
HealthPartners Institute
Primary Progressive Aphasia
05/24
05/24
NCT05669365: The Care Ecosystem Consortium Effectiveness Study

Completed
N/A
1227
US
Care Ecosystem
University of California, San Francisco, Ochsner Health System, Providence Health & Services, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, HealthPartners Institute, University of Colorado, Denver, National Institute on Aging (NIA)
Dementia, Dementia, Vascular, Dementia With Lewy Bodies, Dementia Alzheimers, Frontotemporal Dementia
08/25
08/25
NCT04198870: MitraClip REPAIR MR Study

Active, not recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
12/27
12/35
Siepe, Matthias
NCT02387112: Early Versus Emergency Left Ventricular Assist Device Implantation in Patients Awaiting Cardiac Transplantation

Active, not recruiting
N/A
102
Europe
Early VAD implantation
German Heart Institute, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Helmholtz Zentrum München, University Medicine Greifswald, University of Göttingen
End Stage Heart Disease
03/24
12/24
MANTRA, NCT05002543: CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting

Recruiting
N/A
2150
Europe, Canada, US, RoW
Corcym S.r.l
Cardiac Valve Disease
08/25
12/35
NCT04198870: MitraClip REPAIR MR Study

Active, not recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
12/27
12/35
HARVITA, NCT05931783: Randomized Comparison of Skeletonized Versus Pedicled Left Internal Thoracic Artery

Recruiting
N/A
1350
Europe
skeletonized harvesting technique, pedicled harvesting technique
Medical University Innsbruck
Coronary Artery Disease
10/28
10/31
NCT04073420: Medtronic Cardiac Surgery PMCF Registry

Recruiting
N/A
2700
Europe, US
Surgical Heart Valve Repair Products, Surgical Heart Valve Replacement Products
Medtronic Cardiac Surgery
Valve Disease, Heart
12/39
12/39
Kefer, Joelle
NCT06409117: 3rd Generation Resorbable Magnesium Scaffolds vs Biodegradable Polymer Stents in NSTE/ACS

Not yet recruiting
4
220
Europe
Percutaneous coronary intervention
Konstantinos Toutouzas, Centre Hospitalier Universitaire Saint Pierre, Université Catholique de Louvain, University Hospital of Leuven Leuven, University of Patras, Ippokrateio General Hospital of Thessaloniki
Acute Coronary Syndrome, Coronary Artery Disease
12/27
12/27
NCT04180605: Computational Simulation to Plan for Percutaneous Left Atrial Appendage Closure

Recruiting
N/A
200
Europe, Canada
Additional support for preoperative planning of LAA closure procedures, Left atrial appendage closure
Rigshospitalet, Denmark, Feops, Abbott
Atrial Fibrillation, Stroke Prevention
12/21
12/22
TRICURE EU, NCT06581471: The Pivotal Study

Recruiting
N/A
80
Europe
Transcatheter Tricuspid Valve Replacement, TRiCares Topaz Tricuspid Valve Replacement System
TRiCares
Tricuspid Valve Regurgitation, Heart Valve Disease, Cardiovascular Diseases
10/26
12/30
ABT-CIP-10523, NCT06707688: Abbott Medical - VERITAS Study

Active, not recruiting
N/A
458
Europe, Canada, US
Amulet? 2 Left Atrial Appendage (LAA) Occluder
Abbott Medical Devices
Atrial Fibrillation (AF), Stoke
11/25
09/27
Horton, Rodney
ABT-CIP-10523, NCT06707688: Abbott Medical - VERITAS Study

Active, not recruiting
N/A
458
Europe, Canada, US
Amulet? 2 Left Atrial Appendage (LAA) Occluder
Abbott Medical Devices
Atrial Fibrillation (AF), Stoke
11/25
09/27
CATALYST, NCT04226547: Amplatzer Amulet LAAO vs. NOAC

Active, not recruiting
N/A
2650
Europe, Canada, Japan, US, RoW
Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC
Abbott Medical Devices
Atrial Fibrillation, Stroke, Bleeding
01/29
04/31
NCT03643224: DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation

Completed
N/A
376
Europe, Canada, US, RoW
Radiofrequency Ablation
Medtronic Cardiac Ablation Solutions
Persistent Atrial Fibrillation, Atrial Fibrillation
10/24
10/24
Raeber, Lorenz
ABT-CIP-10523, NCT06707688: Abbott Medical - VERITAS Study

Active, not recruiting
N/A
458
Europe, Canada, US
Amulet? 2 Left Atrial Appendage (LAA) Occluder
Abbott Medical Devices
Atrial Fibrillation (AF), Stoke
11/25
09/27
CATALYST, NCT04226547: Amplatzer Amulet LAAO vs. NOAC

Active, not recruiting
N/A
2650
Europe, Canada, Japan, US, RoW
Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC
Abbott Medical Devices
Atrial Fibrillation, Stroke, Bleeding
01/29
04/31
NCT02241291: CARDIOBASE Bern PCI Registry

Recruiting
N/A
10000
Europe
Percutaneous coronary intervention
University Hospital Inselspital, Berne
Myocardial Ischemia
07/25
07/25
OPTICO-LM, NCT03820492: Comparison of Optical Coherence Tomography-derived Minimal Lumen Area, Invasive Fractional Flow Reserve and FFRCT

Recruiting
N/A
104
Europe, Japan
OCT, FFR, CTA and FFRCT
University Hospital Inselspital, Berne
Coronary Stenosis
12/26
12/26
Cardinal, Deb
REACT-AF, NCT05836987: The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

Recruiting
3
5350
US
AFSW Guided DOAC, Apple Watch, Continuous DOAC therapy, Oral Anticoagulation therapy
Johns Hopkins University, National Heart, Lung, and Blood Institute (NHLBI), Northwestern University
Atrial Fibrillation
07/29
07/29
NCT05327101: Patient Preferences for Leadless Pacemakers

Completed
N/A
117
US
Patient Preference Survey
Abbott Medical Devices
Cardiac Rhythm Disorder, Bradycardia, Cardiac Pacemaker Artificial
06/23
06/23
IMPACT II, NCT04577859: Esophageal Protection Study: A Multicenter Study

Completed
N/A
152
Europe, US
ensoETM. Esophageal cooling during AF ablation, Esophageal temperature monitoring probe
Advanced Cooling Therapy LLC, d/b/a Attune Medical, University of Pennsylvania, Berry Consultants, Texas Cardiac Arrhythmia Research Foundation, Beth Israel Deaconess Medical Center, Kansas City Cardiac Arrhythmia Research LLC
AF - Atrial Fibrillation, Complication, Atrio-Esophageal Fistula
05/26
05/26
DISRUPT-AF, NCT06335082: A Registry Based Collaborative to Measure Efficiency, Effectiveness, and Safety of Farapulse PFA Technology for AF

Enrolling by invitation
N/A
10000
US
Pulsed Field Ablation
Heart Rhythm Clinical and Research Solutions, LLC, Boston Scientific Corporation
Atrial Fibrillation
11/26
01/28
ULTRA-HFIB, NCT04182620: Ultrasound-Based Renal Sympathetic Denervation as Adjunctive Upstream Therapy During Atrial Fibrillation Ablation

Completed
N/A
160
US
renal denervation, Catheter ablation
Vivek Reddy
Atrial Fibrillation
02/25
02/25
INTEGRA-D, NCT05855135: Assessment of Combined CCM and ICD Device in HFrEF

Active, not recruiting
N/A
300
US
OPTIMIZER® Integra CCM-D System (Treatment Arm)
Impulse Dynamics
Heart Failure, Heart Failure With Reduced Ejection Fraction, Implantable Defibrillator User, CCM Therapy, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy, Sudden Cardiac Arrest, Arrhythmias, Cardiac, Ventricular Tachycardia, Ventricular Fibrillation
05/26
07/27
SAFFICIENT, NCT06488820: Safety and Efficacy of Pulsed-field Ablation for Atrial Fibrillation in High Versus Low-volume Ablation Centers

Terminated
N/A
75
US
Catheter ablation using pulsed-field ablation (PFA) system
Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation
04/25
04/25
SIMPLAAFY, NCT06521463: Clinical Trial

Active, not recruiting
N/A
1857
US
WATCHMAN FLX Pro LAAC Device, WATCHMAN FLX Pro Left Atrial Appendage Closure Device
Boston Scientific Corporation
Atrial Fibrillation, Stroke, Bleeding
07/26
01/27
ABT-CIP-10523, NCT06707688: Abbott Medical - VERITAS Study

Active, not recruiting
N/A
458
Europe, Canada, US
Amulet? 2 Left Atrial Appendage (LAA) Occluder
Abbott Medical Devices
Atrial Fibrillation (AF), Stoke
11/25
09/27
EFACT, NCT06699056: AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

Recruiting
N/A
2000
US
15-minutes of sitting during COR ECG Acquistion
Peerbridge Health, Inc
Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement, Conduction Defect, Heart Failure, Valvular Heart Disease, Ischemic Heart Disease, Cardiotoxicity, Myocardial Infarction, Dilated Cardiomyopathy, HFrEF - Heart Failure With Reduced Ejection Fraction, HFpEF - Heart Failure With Preserved Ejection Fraction, Syncope, Remodeling, Cardiac
11/27
11/27
CATALYST, NCT04226547: Amplatzer Amulet LAAO vs. NOAC

Active, not recruiting
N/A
2650
Europe, Canada, Japan, US, RoW
Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC
Abbott Medical Devices
Atrial Fibrillation, Stroke, Bleeding
01/29
04/31
NCT03643224: DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation

Completed
N/A
376
Europe, Canada, US, RoW
Radiofrequency Ablation
Medtronic Cardiac Ablation Solutions
Persistent Atrial Fibrillation, Atrial Fibrillation
10/24
10/24
AIM HIGHer, NCT05064709: Assessment of CCM in HF With Higher Ejection Fraction

Recruiting
N/A
1500
US
Cardiac Contractility Modulation Therapy via OPTIMIZER? Smart Mini System, CCM Group (CCM ON), OPTIMIZER? Smart Mini System, Sham Group (CCM OFF)
Impulse Dynamics
Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Heart Failure With Moderately Reduced Ejection Fraction, Diastolic Heart Failure
02/29
02/29
Sphere-9 VT, NCT06703489: Safety and Performance Assessment of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia ( EFS)

Recruiting
N/A
60
US
Sphere-9 Catheter with the Affera Mapping and Ablation System
Medtronic Cardiac Ablation Solutions
Ventricular Tachycardia (VT)
07/26
01/27
NCT07041125: Concomitant LAAC/AF Ablation (Watchman FLX Pro)

Active, not recruiting
N/A
120
US
Watchman FLX? Pro device.
Heart Rhythm Clinical and Research Solutions, LLC, Boston Scientific Corporation
PFA Ablation and LAAC Procedures
09/26
10/26
ReMATCH, NCT06735534: Repeat Ablation of Persistent Atrial Fibrillation, Including Mitral Isthmus Catheter Ablation, With the FARAPULSE Pulsed Field Ablation System

Recruiting
N/A
376
US, RoW
FARAPULSE? Pulsed Field Ablation System
Boston Scientific Corporation
Persistent Atrial Fibrillation
04/27
01/28
COHERENT-AF, NCT06784466: Coherent Sine Burst Electroporation (CSE) Ablation System US IDE Study for Patients With Atrial Fibrillation

Recruiting
N/A
360
Europe, US, RoW
Arg? Medtech Coherent Sine-Burst Electroporation (CSE) Ablation System
Arga Medtech SA
Atrial Fibrillation (AF), Persistant Atrial Fibrillation, Paroxysmal AF
06/27
08/27
NCT07308847: Horizon 360 Protocol for the Treatment of Paroxysmal Atrial Fibrillation With the Sphere-360? Catheter and Affera? Mapping and Ablation System (Horizon 360)

Recruiting
N/A
300
US
Sphere-360 Pulsed Field Ablation Catheter with the Affera Mapping and Ablation System
Medtronic Cardiac Ablation Solutions
Paroxysmal AF
11/27
11/27
NCT03970343: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy

Active, not recruiting
N/A
620
US
OPTIMIZER Smart System
Impulse Dynamics
Heart Failure
07/28
07/28
NCT05280093: HEAL-IST IDE Trial

Active, not recruiting
N/A
142
Europe, US
AtriCure ISOLATOR Synergy Surgical Ablation System
AtriCure, Inc.
Inappropriate Sinus Tachycardia
02/27
02/28
NCT07585968: Safety and Effectiveness of the Sphere-9? Catheter and Affera? Ablation System for the Treatment of Ventricular Tachycardia (Sphere VT)

Not yet recruiting
N/A
260
US
Sphere-9 Catheter with the Affera Mapping and Ablation System
Medtronic Cardiac Ablation Solutions
Ventricular Tachycardia
03/28
09/28
NCT07575269: Evaluation of the FARAFLEX Mapping and Pulsed Field Ablation System in Subjects With Atrial Fibrillation

Recruiting
N/A
571
Europe, US
FARAFLEX Mapping and Pulsed Field Ablation (PFA) System, FARAFLEX Mapping and Pulsed Field Ablation (PFA) Catheter, FARAFLEX Catheter
Boston Scientific Corporation
Paroxysmal Atrial Fibrillation (PAF), Persistent Atrial Fibrillation
07/28
01/30
Agar, Diane
SAFE-MCS, NCT05077657: Safe Surveillance of PCI Under Mechanical Circulatory Support With the Saranas Early Bird Bleed Monitoring System

Completed
N/A
203
US
Early Bird® Bleed Monitoring System, Impella®
Saranas, Inc., Proxima Clinical Research, Inc., Cardiovascular Research Foundation, New York
Coronary Artery Disease
12/23
12/23
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study

Suspended
N/A
400
Europe, US, RoW
AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy
Ancora Heart, Inc.
Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
12/26
12/30
AIM HIGHer, NCT05064709: Assessment of CCM in HF With Higher Ejection Fraction

Recruiting
N/A
1500
US
Cardiac Contractility Modulation Therapy via OPTIMIZER? Smart Mini System, CCM Group (CCM ON), OPTIMIZER? Smart Mini System, Sham Group (CCM OFF)
Impulse Dynamics
Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Heart Failure With Moderately Reduced Ejection Fraction, Diastolic Heart Failure
02/29
02/29
NCT04198870: MitraClip REPAIR MR Study

Active, not recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
12/27
12/35
Silva, Guilherme
PORTICO IDE, NCT02000115: Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial

Active, not recruiting
N/A
1242
US, RoW
Portico transcatheter aortic valve, Commercially available transcatheter aortic valve
Abbott Medical Devices
Aortic Valve Stenosis
10/19
12/26
CorCinch-PMVI, NCT03560167: Early Feasibility Study of the AccuCinch® Ventricular Restoration System in Patients With Prior Mitral Valve Intervention (PMVI) and Recurrent Mitral Regurgitation

Completed
N/A
5
US
AccuCinch® Ventricular Restoration System
Ancora Heart, Inc.
Heart Failure, Cardiomyopathy, Dilated
03/21
01/24
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Active, not recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
06/26
06/31
CATALYST, NCT04226547: Amplatzer Amulet LAAO vs. NOAC

Active, not recruiting
N/A
2650
Europe, Canada, Japan, US, RoW
Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC
Abbott Medical Devices
Atrial Fibrillation, Stroke, Bleeding
01/29
04/31
CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting
N/A
1270
Canada, US
Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease
12/27
12/31
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid? TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
05/27
09/36
REDUCE PAS, NCT03821129: GORE? CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Recruiting
N/A
636
US
PFO closure with GORE? CARDIOFORM Septal Occluder
W.L.Gore & Associates
Stroke, PFO - Patent Foramen Ovale
10/28
10/31
Genereux, Philippe
NCT02661451: Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

Active, not recruiting
N/A
178
Europe, Canada, US
SAPIEN 3 THV, Optimal Heart Failure Therapy
Cardiovascular Research Foundation, New York, Cardialysis BV, Avania
Aortic Valve Stenosis
02/23
02/25
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Active, not recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
06/26
06/31
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study

Suspended
N/A
400
Europe, US, RoW
AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy
Ancora Heart, Inc.
Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
12/26
12/30
ShortCut CAS, NCT06211296: The ShortCut™ Continued Access Study Protocol

Completed
N/A
8
US
Shortcut
Pi-cardia
Valve-in-valve Procedures, Aortic Stenosis, Coronary; Obstruction
05/25
05/25
NCT03523416: Early Feasibility Study - Edwards APTURE Transcatheter Shunt System

Active, not recruiting
N/A
71
US
Transcatheter Atrial Shunt System
Edwards Lifesciences
Heart Failure
12/23
11/28
NCT06680427: Siegel™ Transcatheter Aortic Valve Replacement System (TAVR) Early Feasibility Study

Active, not recruiting
N/A
30
US
Siegel Transcatheter Aortic Valve (TAVR)
MiRus
Aortic Stenosis Symptomatic
12/25
12/25
NCT03997305: AltaValve Early Feasibility Study Protocol

Recruiting
N/A
15
US
AltaValve
4C Medical Technologies, Inc.
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
09/25
09/25
PROTEMBO, NCT05873816: The Trial

Completed
N/A
284
Europe, US
ProtEmbo - Cerebral Embolic Protection, Sentinel - Cerebral Embolic Protection
Protembis GmbH
Severe Aortic Valve Stenosis
10/25
12/25
NCT04198870: MitraClip REPAIR MR Study

Active, not recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
12/27
12/35
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid? TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
05/27
09/36
Keller, Dorothee
NCT04198870: MitraClip REPAIR MR Study

Active, not recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
12/27
12/35
Praz, Fabien
EXPLORE MR, NCT04098328: Early Feasibility EXperience of Posterior Leaflet RestOration to REduce Mitral Regurgitation

Terminated
N/A
2
Europe
Polares Medical SA
Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Insufficiency
02/23
02/23
TriCLASP, NCT04614402: Transcatheter Repair of Tricuspid Regurgitation With Edwards PASCAL Transcatheter Valve Repair System

Active, not recruiting
N/A
300
Europe
Edwards PASCAL Transcatheter Valve Repair System, Edwards PASCAL Precision Transcatheter Valve Repair System
Edwards Lifesciences
Tricuspid Valve Insufficiency
04/23
03/28
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Active, not recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
06/26
06/31
NCT06569602: Real World European Investigation of Safety and Clinical Efficacy of the EVOQUE System (TRISCEND III EU)

Recruiting
N/A
500
Europe
Transcatheter Tricuspid Valve Replacement, Edwards EVOQUE Tricuspid Valve Replacement System
Edwards Lifesciences
Tricuspid Valve Regurgitation, Heart Valve Diseases, Cardiovascular Diseases
09/30
09/33
CHOICE-MI, NCT04688190: CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

Recruiting
N/A
1000
Europe, Canada, US, RoW
Universitätsklinikum Hamburg-Eppendorf, Montreal Heart Institute, University Hospital, Bordeaux
Mitral Regurgitation, Mitral Valve Disease, Mitral Annular Calcification
12/30
12/30
RESOLVE-MR, NCT04818502: Real World Study of the Tendyne™ Mitral Valve System to Treat Mitral Regurgitation

Active, not recruiting
N/A
200
Europe, RoW
Tendyne™ Mitral Valve System, Transcatheter Mitral Valve Implantation (TMVI)
Abbott Medical Devices
Mitral Valve Regurgitation
04/24
05/28
NCT04198870: MitraClip REPAIR MR Study

Active, not recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
12/27
12/35
PASTE, NCT05328284: PASCAL for Tricuspid Regurgitation - a European Registry

Recruiting
N/A
1000
Europe
PASCAL leaflet repair system
LMU Klinikum
Tricuspid Regurgitation
05/23
05/24
TENDER, NCT04898335: Tendyne European Experience Registry

Recruiting
N/A
400
Europe
Tendyne Mitral Valve System
Klinikum der Universitaet Muenchen
Mitral Regurgitation
12/26
12/27
Noti, Fabian
NCT06048731: Enlighten Study: The EV-ICD Post Approval Registry

Active, not recruiting
N/A
1000
Europe, Canada, US, RoW
Defibrillation using EV-ICD
Medtronic
Ventricular Arrhythmia, Tachycardia
05/30
10/37
Perez, Kristina
ABT-CIP-10523, NCT06707688: Abbott Medical - VERITAS Study

Active, not recruiting
N/A
458
Europe, Canada, US
Amulet? 2 Left Atrial Appendage (LAA) Occluder
Abbott Medical Devices
Atrial Fibrillation (AF), Stoke
11/25
09/27
CATALYST, NCT04226547: Amplatzer Amulet LAAO vs. NOAC

Active, not recruiting
N/A
2650
Europe, Canada, Japan, US, RoW
Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC
Abbott Medical Devices
Atrial Fibrillation, Stroke, Bleeding
01/29
04/31
 

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