| BRIANDET, Claire |
| Recruiting | 3 | 800 | Europe, RoW | Vincristine, L01CA02, Carboplatin, LO1XA02, Etoposide, L01CB01, Vindesine, L01CA03, Dacarbazine, L01AX04, Ifosfamide, Doxorubicin, L01DB01, Busulfan, L01AB01, Melphalan, L01AA03, Thiotepa, L01AC01, Radiotherapy, Dinutuximab Beta, L01XC16, Cisplatin, L01XA01, Temozolomide 100 MG, Irinotecan, Cyclophosphamid | Gustave Roussy, Cancer Campus, Grand Paris, PHRC, Solving Kids' Cancer Europe, Neuroblastoma UK, , BSPHO, Instituto de Investigación Sanitaria La Fe, Deutsche Krebshilfe | High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy | 11/26 | 11/32 | | |
| Recruiting | 3 | 409 | Europe | Everolimus, VOTUBIA, AFINITOR, ONC201, Radiotherapy | Gustave Roussy, Cancer Campus, Grand Paris, Chimerix, Innovative Therapies For Children with Cancer Consortium, Ministry of Health, France | Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant | 09/28 | 09/31 | | |
| Recruiting | 2/3 | 536 | Europe, RoW | 16 weeks of VEC + CDDP, Vincristine, Etoposide, Cyclophosphamide, Cisplatin, VEC + HD-MTX, Methotrexate, Chemotherapy + Valproate, Carboplatin, Valproate, Conformal radiotherapy, VEC, Chemotherapy, conformal radiotherapy +/- boost | Centre Leon Berard | Childhood Ependymoma | 06/28 | 08/31 | | |
| Recruiting | 2/3 | 225 | Europe | Melphalan or Melphalan + Topotecan, Alkeran, Topotecan Accord; Topotecan Hospira chemotherapy, etoposide, carboplatin and vincristine or local ophthalmological treatment without IV chemotherapy, etoposide, carboplatin and vincristine chemotherapy, Carboplatin administered on Day 1, platinum-based chemotherapy, Thermotherapy (local treatment), Thermotherapy after carboplatin administered on Day 1, Cryotherapy (local treatment), Iodine-125 plaques (local treatment), Intravitreal Melphalan chemotherapy injections (local treatment) | Institut Curie, Fondation Rothschild Paris | Retinoblastoma | 01/35 | 01/36 | | |
| Active, not recruiting | 2 | 133 | Europe | VP16, carboplatin, etoposide, vepesid, chemotherapy, Melphalan, Alkeran, chemotherapy, VP16, carboplatin, vincristin, etoposide, vepesid, leurocristine, Oncovin, chemotherapy, Carboplatin + laser day 1 (chemothermotherapy), Carbo-laser, platinum-based chemotherapy, Laser (local treatment), Laser diode, cryoapplication (local treatment), I125 radioactive plaques (local treatment), intravitreal Melphalan (local treatment) | Institut Curie, Fondation Rothschild Paris | Retinoblastoma, Children, Retinal Neoplasm | 01/23 | 09/35 | | |
| Recruiting | 2 | 185 | Europe | Observation, Low risk group, Etoposide, Intermediate risk sub group 1, Vincristine, Intermediate risk sub group 2, Orbital irradiation, High risk group, Carboplatin, Cyclophosphamide, Thiotepa, Cytapheresis, Peripheral bood stem cell transplantation | Institut Curie | Retinoblastoma | 03/30 | 09/30 | | |
NEUROBLU 02, NCT03966651 / 2020-002996-36: A Clinical Study Evaluating the Safety of Peptide Receptor Radionuclide Therapy (PRRT) With 177Lu-DOTA0-Tyr3-Octreotate in Children With Refractory or Recurrent Neuroblastoma Expressing Somatostatin Receptors. |
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| Recruiting | 1 | 18 | Europe | PRRT with 177Lu-DOTATATE | Institut Claudius Regaud, Advanced Accelerator Applications | Neuroblastoma | 10/25 | 02/26 | | |
NCT03306251: National Cohort of Children Born to HIV-positive Mothers |
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| Recruiting | N/A | 5200 | Europe, RoW | | ANRS, Emerging Infectious Diseases | Mother to Child Transmission of HIV | 03/23 | 03/23 | | |
SACHA, NCT04477681: Securing Access to Innovative Molecules in Oncology and Hematology for Children, Adolescents and Young Adults |
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| Recruiting | N/A | 1000 | Europe | Data collection | Gustave Roussy, Cancer Campus, Grand Paris, Société Française des Cancers de l'Enfant (SFCE) | Pediatric Cancer | 04/26 | 04/27 | | |
MICCHADO, NCT03496402: Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults |
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| Active, not recruiting | N/A | 600 | Europe | Sampling on blood, bone marrow and cerebrospinal fluid | Institut Curie | Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma Family of Tumors, Osteosarcoma, Leukemia, Central Nervous System Tumor | 04/27 | 08/27 | | |
BIOPORTAL, NCT05192980: SIOPEN , An International Registry Linked to a Virtual Biobank for Patients With Peripheral Neuroblastic Tumours |
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| Recruiting | N/A | 600 | Europe | No Intervention NA, Bio-sampling | Institut Curie | Neuroblastoma, Ganglioneuroblastoma, Ganglioneuroma | 11/38 | 11/38 | | |
| Recruiting | N/A | 40 | Europe | | University Hospital, Strasbourg, France | Primary Brain Tumor | 12/23 | 12/23 | | |
| HONNART, Didier |
HIFLOWED, NCT04607967: HFNO or Conventional Oxygen Therapy for Patients With Acute Hypoxemic Respiratory Distress |
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| Recruiting | N/A | 500 | Europe | High Flow Nasal Oxygen, HNFO (High Flow Nasal Oxygen) | Centre Hospitalier Universitaire de Besancon, Centre Hospitalier Universitaire Dijon, centre Hospitalier Intercommunal de Vesoul, Centre Hospitalier Universitaire de Saint Louis APHP, Poitiers University Hospital, University Hospital, Clermont-Ferrand, Rennes University Hospital, Centre Hospitalier of Chartres, University Hospital, Toulouse, University Hospital, Montpellier | Acute Hypoxemic Respiratory Distress | 05/25 | 06/25 | | |
| OLIVIER-FAIVRE, Laurence LO |
SESAM, NCT05577754: Assessment of the Efficacy and Safety of Alpelisib (BYL719) in Pediatric and Adult Patients with Megalencephaly-CApillary Malformation Polymicrogyria Syndrome (MCAP) |
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| Recruiting | 2 | 20 | Europe | Alpelisib (BYL719), Matching placebo, Optional lumbar puncture + blood sample | Centre Hospitalier Universitaire Dijon, Novartis Pharmaceuticals | Megalencephaly-capillary Malformation Polymicrogyria Syndrome (MCAP) | 03/27 | 03/27 | | |
PRENATOMEultra, NCT06252415: Evaluation of Rapid First-line Genome Sequencing for Prenatal Diagnosis of Congenital Malformations in Comparison With Chromosomal Microarray and Exome Sequencing |
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| Recruiting | N/A | 180 | Europe | foetal amniotic fluid sample, blood samples, semi-structured online interviews | Centre Hospitalier Universitaire Dijon | Congenital Malformation | 06/26 | 06/26 | | |
S4C France, NCT06528548: Genetic Newborn Screening for Rare Diseases Within the Screen4Care Project: the French Participation |
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| Not yet recruiting | N/A | 1060 | Europe | DBS card, Blood samples | Centre Hospitalier Universitaire Dijon | Genetic Predisposition to Disease | 06/27 | 06/27 | | |
| Recruiting | N/A | 50 | Europe | Biological samples, Genetic test | Centre Hospitalier Universitaire Dijon | Rare Diseases | 11/24 | 11/24 | | |
| Recruiting | N/A | 300 | Europe, RoW | Collection of blood sample or saliva, Collection of a tumor sample taken before the participation of the patient in study, Collection of blood sample if tumor sample is not available | University Hospital, Angers | Predisposition, Genetic, Cancer Childhood, Development Delay | 02/25 | 08/25 | | |
| Recruiting | N/A | 400 | Europe | Questionnaire | Hospices Civils de Lyon | Vascular Anomaly, Osler Rendu Disease, Marfan Syndrome or Related, Lymphedema Primary, Arteriovenous Malformations, Cerebrospinal; Disorder | 02/27 | 11/28 | | |
| Recruiting | N/A | 850 | Europe | Blood sample, high-throughput sequencing | Centre Hospitalier Universitaire Dijon | Developmental Anomalies | 03/27 | 12/27 | | |
| Recruiting | N/A | 45 | Europe | Blood samples, Skin biopsies, Fetal samples | Hospices Civils de Lyon | Taybi Linder Syndrome, Microcephalic Osteodysplastic Primordial Dwarfism Types I and III, Roifman Syndrome, Lowry Wood Syndrome | 08/29 | 08/29 | | |
Obs du Diag, NCT05448326: The Diagnostic Observatory: Combating Diagnostic Wandering and Impasse Within the AnDDI-Rares Network |
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| Recruiting | N/A | 1280 | Europe | Questionnaire to assess expectations of a diagnosis, Questionnaire to assess understanding of previously reported results and expectations of a diagnosis, Blood sample +/- skin biopsy | Centre Hospitalier Universitaire Dijon | Developmental Abnormality | 03/27 | 03/27 | | |
| Latournerie, Marianne |
ProPILARifax, NCT03069131: Two Strategies of Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Severe Cirrhotic Patients With Ascites |
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| Completed | 3 | 160 | Europe | Rifaximin, Placebo | Centre Hospitalier Universitaire de Besancon, Alfasigma S.p.A., LC2 PHARMA | Cirrhosis, Ascites, Peritonitis | 06/22 | 03/23 | | |
| Completed | N/A | 104 | Europe | Transjugular Portosytemic Shunt (TIPS), glue obliteration | Centre Hospitalier Universitaire de Besancon | Bleeding Gastric Varices, Cirrhosis | 03/23 | 02/24 | | |
| Recruiting | N/A | 150 | Europe | | Federation Francophone de Cancerologie Digestive, Société Nationale Française de Gastroentérologie | Hepatocholangiocarcinoma, Fibrolamellar Carcinoma, Hepatic Epithelioid Hemangioendothelioma, Hepatoblastoma, Hepatic Neuroendocrine Carcinoma, Hepatic Carcinosarcomas, Hepatic Cystadenoma, Hepatic Leiomyosarcomas, Hepatic Angiosarcomas, Cholangiocarcinoma | 02/26 | 02/31 | | |
| Not yet recruiting | N/A | 60 | Europe | MRI, Blood sampling | Centre Hospitalier Universitaire de Besancon | Cirrhosis | 09/25 | 06/27 | | |
| FAUQUE, Patricia |
FERTICOVID, NCT04487639: Presence of SARS-CoV-2 (COVID-19) in Semen: Impact on Fertility Preservation in Male Oncological Patients ? |
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| Completed | N/A | 129 | Europe | SARS-CoV-2 research in nasopharyngeal swab, sperm and serologics | University Hospital, Clermont-Ferrand, Agence de La Biomédecine | Sperm Preservation in Oncological Patients, Fertility, Cryopreservation | 07/21 | 12/23 | | |
NCT02171884: Study of the Impact of Freezing-thawing Procedures and the Prolonged Culture of Embryos on Epigenetic Regulation in Humans |
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| Completed | N/A | 298 | Europe | Sample of cord blood, Sample of placenta | Centre Hospitalier Universitaire Dijon | Assisted Reproductive Technology, Freezing/Thawing Procedure, Prolonged Culture Procedure | 05/22 | 05/22 | | |
Devit, NCT04758819: Efficiency of Comprehensive Chromosomal Testing of Trophectoderm Biopsies of Blastocysts in In Vitro Fertilization |
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| Recruiting | N/A | 700 | Europe | Comprehensive chromosomal Testing of Trophectoderm biopsies of Blastocysts (CTTEB) | Assistance Publique - Hôpitaux de Paris | Infertility | 01/26 | 01/26 | | |
NCT02171845: Mechanisms and Factors Responsible for the Inhibition of Transposons During Fetal Gonad Development in Humans |
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| Recruiting | N/A | 30 | Europe | surgical biopsies | Centre Hospitalier Universitaire Dijon | Medical Termination of Pregnancy, Voluntary Termination of Pregnancy | 01/27 | 01/27 | | |
| Not yet recruiting | N/A | 300 | Europe | Questionnaire, Interview | Central Hospital, Nancy, France, National Cancer Institute, France | Fertility Issues, Childhood Cancer, Psychology, Social | 12/23 | 03/24 | | |
| SIMON |
| Active, not recruiting | 3 | 9541 | Europe, Canada, Japan, US, RoW | Obicetrapib, Placebo | NewAmsterdam Pharma, Monash University | Atherosclerotic Cardiovascular Disease | 11/26 | 11/26 | | |
MISC-TRAIN, NCT06647849: Interest of Simulation Training on the Announcement of Early Pregnancy Loss on the Psychological Impact of the Patients |
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| Recruiting | N/A | 1000 | Europe | centers whose interns receive simulation training in the announcement of early spontaneous miscarriage between the 2 inclusion phases, centers with standard in-house management of spontaneous miscarriage/pregnancy arrested in the emergency department | University Hospital, Angers, Direction Générale de l'Offre de Soins | Early Pregnancy Loss, Spontaneous Miscarriage | 05/25 | 06/26 | | |
| Moreau, Thibault TM |
TWINS, NCT06663189: Disease Modifying Therapies Withdrawal in Inactive Relapsing-remitting Multiple Sclerosis Patients Aged 55 and Over ( : Therapies Withdrawal IN Relapsing Multiple Sclerosis) |
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| Not yet recruiting | 3 | 200 | Europe | treatment withdrawal, Usual DMT continuation, MRI, Quality of Life questionnaires, Disability evaluation tests | University Hospital, Strasbourg, France, Ministry of Health, France | Relapsing-remitting Multiple Sclerosis (RRMS) | 01/27 | 06/29 | | |
STOP-I-SEP, NCT03653273: Disease Modifying Therapies Withdrawal in Inactive Secondary Progressive Multiple Sclerosis Patients Older Than 50 Years |
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| Recruiting | 3 | 250 | Europe | DMT withdrawal, DMT continuation | Rennes University Hospital | Multiple Sclerosis | 07/26 | 01/28 | | |
| Completed | N/A | 68 | Europe, RoW | Questionnaire | University Hospital, Bordeaux, Biogen | Multiple Sclerosis | 12/23 | 12/23 | | |
| Recruiting | N/A | 150 | Europe | Clinical assessment, Classical cognitive evaluation of several domains:, Ecological evaluation, Patent reported outcomes (PRO's), Telerehabilitation : active procedure, Telerehabilitation : comparator procedure | University Hospital, Bordeaux, Celgene | Multiple Sclerosis | 02/25 | 02/25 | | |
NeurofilMS, NCT03981003: Serum Neurofilament-light Chain and GFAP Levels in Patients From the OFSEP Cohort at Different Landmarks of Multiple Sclerosis |
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| Recruiting | N/A | 1150 | Europe, RoW | Blood sample | Centre Hospitalier Universitaire de Nīmes, Hospices Civils de Lyon | Multiple Sclerosis | 06/28 | 06/28 | | |
| Recruiting | N/A | 1000 | Europe, RoW | No intervention | Hospices Civils de Lyon | Sclerosis, Multiple, Neuromyelitis Optica Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein (MOG)-Antibody Related Disorders, Pregnancy Abnormal | 08/36 | 08/36 | | |
BiomarPark, NCT05110547: Multicenter Study of Blood Biomarkers of Mitochondrial and Peroxisomal Metabolism to Differentiate Idiopathic Parkinson's Disease From Related Conditions |
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| Recruiting | N/A | 75 | Europe | blood collection | Centre Hospitalier Universitaire Dijon | Idiopathic Parkinson Disease, Parkinsonian Syndrome | 04/23 | 04/23 | | |
| Facy, Olivier |
FLUOCOL-1, NCT05168839: Intraoperative Indocyanine Green Fluorescence Angiography in Colorectal Surgery to Prevent Anastomotic Leakage |
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| Recruiting | 3 | 1010 | Europe | FLUO+ : Intraoperative fluorescence angiography (IOFA) with indocyanine green (ICG). | Centre Hospitalier Universitaire de Besancon | Colorectal Cancer | 10/25 | 10/25 | | |
| SEMAMA, DENIS |
LaparoDAN, NCT04174807: Prospective Study of Antenatal Diagnostic Criteria for Digestive Complications of Gastroschisis |
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| Recruiting | N/A | 200 | Europe, RoW | | University Hospital, Angers | Gastroschisis, Intestinal Occlusion | 05/22 | 05/22 | | |
| Ramon, Andre |
NCT06186375: Performance of PEAR 2.0 Software in Prescribing Biotherapy in Patients With Rheumatoid Arthritis |
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| Recruiting | N/A | 234 | Europe | Patients with planned biotherapy | CEN Biotech, MYEXPRESION | Polyarthritis; Rheumatoid | 06/25 | 08/25 | | |
MAJIK, NCT04602091: Observational Study in Patients Treated With JAK Inhibitors for Inflammatory Rheumatism |
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| Recruiting | N/A | 2300 | Europe | no intervention | Societe Francaise de Rhumatologie, Bordeaux PharmacoEpi | Rheumatoid Arthritis, Inflammatory Rheumatism, Psoriatic Arthritis, Spondyloarthritis | 06/26 | 06/30 | | |
| Moreno, Nathan |
FLUOCOL-1, NCT05168839: Intraoperative Indocyanine Green Fluorescence Angiography in Colorectal Surgery to Prevent Anastomotic Leakage |
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| Recruiting | 3 | 1010 | Europe | FLUO+ : Intraoperative fluorescence angiography (IOFA) with indocyanine green (ICG). | Centre Hospitalier Universitaire de Besancon | Colorectal Cancer | 10/25 | 10/25 | | |
| Moreno-Lopez, Nathan |
FLUOCOL-1, NCT05168839: Intraoperative Indocyanine Green Fluorescence Angiography in Colorectal Surgery to Prevent Anastomotic Leakage |
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| Recruiting | 3 | 1010 | Europe | FLUO+ : Intraoperative fluorescence angiography (IOFA) with indocyanine green (ICG). | Centre Hospitalier Universitaire de Besancon | Colorectal Cancer | 10/25 | 10/25 | | |
| Ducarme |
MISC-TRAIN, NCT06647849: Interest of Simulation Training on the Announcement of Early Pregnancy Loss on the Psychological Impact of the Patients |
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| Recruiting | N/A | 1000 | Europe | centers whose interns receive simulation training in the announcement of early spontaneous miscarriage between the 2 inclusion phases, centers with standard in-house management of spontaneous miscarriage/pregnancy arrested in the emergency department | University Hospital, Angers, Direction Générale de l'Offre de Soins | Early Pregnancy Loss, Spontaneous Miscarriage | 05/25 | 06/26 | | |
