| Renko, Marjo |
| Recruiting | 4 | 530 | Europe | E. coli Nissle, Mutaflor, Placebo control | University of Oulu, Turku University Hospital, Kuopio University Hospital, Tampere University Hospital, Helsinki University Central Hospital | Urinary Tract Infections in Children, Secondary Prevention | 12/24 | 12/24 | | |
| Recruiting | N/A | 80 | Europe | VHC 1, VHC 2 | Tampere University, Kuopio University Hospital, Oulu University Hospital, Tampere University Hospital, Terveystalo Healthcare Services | Bronchitis Obstructive, Bronchiolitis; Obstruction, Bronchospasm; Bronchitis | 05/26 | 12/28 | | |
NCT06321133: High Flow Nasal Cannula Weaning in Acute Bronchiolitis |
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| Recruiting | N/A | 50 | Europe | High flow nasal cannula immediate ending, High flow nasal cannula weaning | Kuopio University Hospital, Central Finland Hospital District, Mikkeli Central Hospital, Siun sote | Acute Bronchiolitis | 12/26 | 12/26 | | |
| Tammela, Teuvo L |
NCT03139734: Sacral Neuromodulation for Pelvic Pain Associated With Endometriosis |
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| Recruiting | N/A | 50 | Europe | Sacral Neuromodulation, Sacral Nerve Stimulation, Sacral Nerve Modulation | Seinajoki Central Hospital, Helsinki University Central Hospital, Turku University Hospital, Tampere University Hospital, Oulu University Hospital, Jyväskylä Central Hospital | Endometriosis | 05/22 | 05/22 | | |
| Recruiting | N/A | 1200 | Europe | Prostatectomy/Surgery, Radiotherapy with adjuvant androgen deprivation therapy | Olof Akre | Prostatic Neoplasms | 12/25 | 12/45 | | |
| Mechlenburg, Inger Mechlenburg B |
NCT00408291: Evaluation of Treatment of Fractures of the Humerus With a Plate. |
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| Completed | N/A | 36 | Europe | Winsta PH osteosynthesis device, Winsta PH osteosynthesis device (Fischer Medical) | University of Aarhus | Fracture | 04/22 | 03/23 | | |
PROHIP, NCT04070027: Progressive Resistance Training Versus Total Hip Arthroplasty in Patients With Hip Osteoarthritis |
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| Active, not recruiting | N/A | 109 | Europe | Total Hip Arthroplasty, Total Hip Replacement, Progressive Resistance Training, Strength Training, Exercise | Vejle Hospital, Odense University Hospital, Naestved Hospital, Aarhus University Hospital, The Danish Rheumatism Association, Region of Southern Denmark, Association of Danish Physiotherapists, The Research Council at Naestved-Slagelse-Ringsted Hospitals | Hip Osteoarthritis | 05/22 | 06/26 | | |
NCT04081493: The Efficacy of Low-load Blood Flow Restricted Resistance Before TKR |
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| Completed | N/A | 86 | Europe | Low-load blood flow restricted exercise | University of Aarhus, Horsens Hospital, Regionshospitalet Silkeborg | Total Knee Replacement | 06/23 | 04/24 | | |
HipBooster, NCT04714047: Progressive Resistance Training Compared to Neuromuscular Exercise in Patients With Hip Osteoarthritis |
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| Completed | N/A | 160 | Europe | Progressive Resistance Training and no booster sessions, Progressive Resistance Training and booster sessions, Neuromuscular exercise and no booster sessions, Neuromuscular exercise and booster sessions | University of Aarhus, Vejle Hospital, Naestved Hospital, Regional Hospital Holstebro, Aarhus University Hospital, Physiotherapy Associates, Slagelse Hospital, University of Southern Denmark, Regionshospitalet Silkeborg | Hip Osteoarthritis | 05/24 | 05/24 | | |
EDUEX, NCT06391554: Effects of EDUcation and EXercise Compared to Education Alone on Clinical and Physiological Outcomes in Patients With Hip Osteoarthritis |
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| Recruiting | N/A | 150 | Europe | PRT, EDU | University of Aarhus, Aarhus University Hospital, Regionshospitalet Silkeborg, Vejle Hospital, Physiotherapy Associates | Hip Osteoarthritis | 05/27 | 05/27 | | |
StrongHip, NCT05657054: Exercise Intervention Targeting Hip Strengthening Compared to Usual Care in Patients Undergoing Revision Hip Replacement |
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| Active, not recruiting | N/A | 84 | Europe | Exercise Intervention Targeting Hip Strengthening, Usual Care | University of Aarhus, Aarhus University Hospital, Vejle Hospital, Regionshospitalet Silkeborg, Gødstrup Hospital, Viborg Regional Hospital, Odense University Hospital, Bispebjerg Hospital, University Hospital, Gentofte, Copenhagen | Revision Total Hip Arthroplasty | 12/24 | 12/27 | | |
| Recruiting | N/A | 200 | Europe | Exercise and patient education, Usual Care | University of Aarhus, Research Unit for General Practice, Aarhus University, VIA University College, Copenhagen University Hospital, Hvidovre, Defactum, Central Denmark Region | Hip Dysplasia | 07/27 | 12/27 | | |
NCT03941171: Is Periacetabular Osteotomy Superior to Progressive Resistance Training? |
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| Active, not recruiting | N/A | 69 | Europe | PAO, Usual care after PAO, PRT | University of Aarhus, Aarhus University Hospital, VIA University College | Hip Dysplasia | 09/25 | 12/25 | | |
BEAN, NCT06434272: Blood Flow Restriction Exercise in Patients with an Achilles Tendon Rupture |
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| Not yet recruiting | N/A | 218 | NA | Early exercise with partial Blood Flow Restriction, BFR, BFRE, Blood Flow Restriction Exercise, BFR-T, Blood Floow Restriciton Training, LL-BFR, Low Load Blood Flow Restriction, Late exercise with partial Blood Flow Restriction, Blood Flow Restriction Training | University of Aarhus, Aarhus University Hospital, Aalborg University Hospital, Gødstrup Hospital, Regionshospitalet Horsens | Achilles Tendon Rupture | 01/26 | 01/26 | | |
| Recruiting | N/A | 120 | Europe, RoW | Supervised strength exercise intervention, Minimal educational intervention (usual care) | University of Aarhus, Horsens Hospital, Aalborg University Hospital, Aarhus University Hospital, Odense University Hospital, La Trobe University, Hvidovre University Hospital | Femoroacetabular Impingement Syndrome | 07/26 | 07/27 | | |
PROACT, NCT04845074: Prosthesis Versus Active Exercise Program in Patients With Glenohumeral Osteoarthritis |
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| Recruiting | N/A | 102 | Europe | TSA-group, Exercise-group | University of Aarhus, Aarhus University Hospital, Tampere University Hospital, Regionshospitalet Viborg, Skive, Aalborg University Hospital, Regionshospitalet Silkeborg, Oslo University Hospital, The Danish Rheumatism Association, Association of Danish Physiotherapists, Esbjerg Hospital | Glenohumeral Osteoarthritis | 11/25 | 11/35 | | |
REACT, NCT04864158: Prosthesis Versus Active Exercise Program in Patients With Rotator Cuff Arthropathy |
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| Recruiting | N/A | 102 | Europe | TSA-group, Exercise-group | University of Aarhus, Aarhus University Hospital, Tampere University Hospital, Aalborg University Hospital, Regionshospitalet Silkeborg, Oslo University Hospital, The Danish Rheumatism Association, Association of Danish Physiotherapists, Regionshospitalet Viborg, Skive | Rotator Cuff Arthropathy | 11/28 | 11/38 | | |
| Järvelä, Timo |
NCT00428870: Operative or Conservative Treatment for Subacromial Impingement Syndrome? |
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| Active, not recruiting | N/A | 210 | Europe | Arthroscopic acromioplasty or arthroscopy alone (sham) or conservative treatment (rehabilitation) | University of Helsinki | Subacromial Impingement Syndrome | 12/24 | 12/24 | | |
| Khan, Jahangir A |
NCT05094843: The Cardiac Stress and Electrocardiographic Changes Caused by Lung Cancer Surgery |
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| Recruiting | N/A | 100 | Europe | | Tampere University Hospital | Lung Cancer, Surgery, Arrhythmia, Myocardial Ischemia | 12/28 | 12/28 | | |
| Sand, Juhani A |
NCT04151693: Health Psychological Group Rehabilitation for Patients With Chronic Fatigue Syndrome (ME/CFS) |
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| Recruiting | N/A | 80 | Europe | Health Psychological Group Rehabilitation for Patients With Chronic Fatigue Syndrome (ME/CFS) | Joint Authority for Päijät-Häme Social and Health Care, TheWellbeing Services County of Pirkanmaa, Charite-Institute of Medical Immunology | Psychological Adaptation, Cognitive Change, Adaptive Behavior, Functioning | 05/28 | 05/28 | | |
| Pesola, Maija |
| Recruiting | N/A | 98 | Europe | Locking plate, TKR | Central Finland Hospital District, Tampere University Hospital, Coxa, Hospital for Joint Replacement, Oulu University Hospital, Turku University Hospital, Kuopio University Hospital, Seinajoki Central Hospital, Paijat-Hame Hospital District | Tibial Fractures | 06/26 | 06/29 | | |
| Kellokumpu-Lehtinen, Pirkko-Liisa i |
| Active, not recruiting | 3 | 378 | Europe | docetaxel, LHRH ananlog 9 months | Scandinavian Prostate Cancer Group, Sanofi | Prostate Cancer | 08/23 | 08/23 | | |
NCT03189576: Measuring Molecular Residual Disease in Colorectal Cancer After Primary Surgery and Resection of Metastases |
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| Active, not recruiting | N/A | 37 | Europe | blood draw | Tampere University Hospital | Colorectal Cancer, Residual Disease | 08/23 | 08/23 | | |
| Salminen, Paulina |
| Recruiting | 4 | 120 | Europe, Canada, US, RoW | Metabolic surgery, Bariatric surgery, Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG), Incretin-Based Therapy, Glucagon-like Peptide-1 Receptor Agonist | Ali Aminian | Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis (MASH), Liver Fibrosis, Obesity | 05/29 | 12/29 | | |
| Active, not recruiting | N/A | 530 | Europe | Appendicectomy, Ertapenem | Turku University Hospital, Oulu University Hospital, Tampere University Hospital, Mikkeli Central Hospital, Jyväskylä Central Hospital, Seinajoki Central Hospital | Acute Appendicitis | 06/12 | 12/25 | | |
| Active, not recruiting | N/A | 110 | NA | Interval appendectomy, Follow-up with MRI | Turku University Hospital, Oulu University Hospital | Periappendicular Abscess | 09/17 | 12/30 | | |
| Active, not recruiting | N/A | 552 | Europe | Ertapenem, Levofloxacin, Metronidazole, Moxifloxacin | Turku University Hospital, Oulu University Hospital, Tampere University Hospital, Kuopio University Hospital, Mikkeli Central Hospital, Lapland Central Hospital, Jyväskylä Central Hospital, Satakunta Central Hospital, Seinajoki Central Hospital | Acute Appendicitis | 11/18 | 04/29 | | |
| Enrolling by invitation | N/A | 147 | Europe | Ertapenem, Levofloxacin, Metronidazole, Placebo | Turku University Hospital, Tampere University Hospital, Kuopio University Hospital, Oulu University Hospital, Helsinki University Central Hospital | Acute Appendicitis | 09/20 | 08/29 | | |
MAPPAC, NCT03257423: Acute Appendicitis and Microbiota - Etiology of Appendicitis and Antibiotic Therapy Effects |
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| Enrolling by invitation | N/A | 200 | Europe | Ertapenem followed by levofloxacin and metronidazole, Moxifloxacin, Appendectomy, Placebo | Turku University Hospital, Tampere University Hospital, Oulu University Hospital, Kuopio University Hospital, Helsinki University Central Hospital, Jyväskylä Central Hospital | Acute Appendicitis | 12/22 | 12/25 | | |
| Not yet recruiting | N/A | 400 | NA | Interval appendectomy, Follow-up MRI at 1 year | Turku University Hospital, Oulu University Hospital, Tampere University Hospital, Kuopio University Hospital, Jyväskylä Central Hospital, Mikkeli Central Hospital, Lapland Central Hospital, Vaasa Central Hospital, Vaasa, Finland, Seinajoki Central Hospital, North Karelia Central Hospital, South Carelia Central Hospital, Päijänne Tavastia Central Hospital, Satakunta Central Hospital | Appendix Abscess, Appendicitis, Appendix Mass, Appendix Cancer, Appendix Nec, Appendix Tumor, Appendix Diseases | 12/22 | 12/35 | | |
APPAC IV, NCT06210269: Oral Antibiotic Outpatient Therapy vs. Placebo in the Treatment of Uncomplicated Acute Appendicitis |
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| Not yet recruiting | N/A | 498 | Europe | Moxifloxacin 400mg, Placebo | Turku University Hospital, Tampere University Hospital, Oulu University Hospital, Kuopio University Hospital, Pori Central Hospital, Jyväskylä Central Hospital, Mikkeli Central Hospital, Seinajoki Central Hospital, Päijänne Tavastia Central Hospital | Uncomplicated Acute Appendicitis | 12/25 | 12/45 | | |
| Kuitunen, Anne H |
Tinza-SLEDD, NCT03614741: Efficacy, Safety and Pharmacokinetics of Tinzaparin During Slow Low Efficient Daily Dialysis in Intensive Care Patients |
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| Recruiting | 4 | 60 | Europe | Tinzaparin continuous infusion, Tinzaparin bolus | Tampere University Hospital | Acute Kidney Injury, Renal Replacement Therapy, Anticoagulants | 12/25 | 12/25 | | |
| Completed | N/A | 325 | Europe | NIRS monitoring | Helsinki University Central Hospital, Tampere University Hospital, Kuopio University Hospital, Medtronic | Circulatory Failure | 06/23 | 10/23 | | |
| Laitinen, Minna |
NCT02879656: Non-operative Treatment Versus Volar Locking Plate in Treatment of Distal Radius Fracture in Patients Over 65 Years |
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| Completed | N/A | 277 | Europe | non-operative treatment, operative treatment | Tampere University Hospital, Central Finland Hospital District, Satakunta Central Hospital, Regionshospitalet Viborg, Skive | Distal Radius Fracture | 06/23 | 06/23 | | |
| Recruiting | N/A | 98 | Europe | Locking plate, TKR | Central Finland Hospital District, Tampere University Hospital, Coxa, Hospital for Joint Replacement, Oulu University Hospital, Turku University Hospital, Kuopio University Hospital, Seinajoki Central Hospital, Paijat-Hame Hospital District | Tibial Fractures | 06/26 | 06/29 | | |
| Silvennoinen, Raija H |
| Completed | 2 | 15 | Europe | Carfilzomib for Inj 60 milligram (MG), Proteasome inhibitor, Elotuzumab 400 MG, Monoclonal antibody, Dexamethasone, Steroid | Raija Silvennoinen, Amgen, Bristol-Myers Squibb, Hospital District of Helsinki and Uusimaa | Multiple Myeloma in Relapse | 08/23 | 08/23 | | |
NCT03376672: Ixazomib Plus Lenalidomide Plus Dexamethasone for Newly Diagnosed Myeloma Patients |
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| Active, not recruiting | 2 | 120 | Europe | Ixazomib, Lenalidomide, Dexamethasone | Raija Silvennoinen, Nordic Myeloma Study Group, Celgene, Takeda | Multiple Myeloma | 12/27 | 12/27 | | |
| Investigator, Principal |
| Completed | 4 | 144 | Europe | Opicapone 50 mg, BIA 9-1067, Placebo | Bial - Portela C S.A., Bial - Portela & Ca, S.A. | Parkinson Disease | 02/24 | 02/24 | | |
NCT04248205: Ketamine for Post-operative Analgesia in Hemorrhoidectomy |
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| Recruiting | 4 | 100 | US | Ketamine | University of Oklahoma | Hemorrhoids | 01/25 | 07/25 | | |
NCT05400369: A Study to Evaluate the Efficacy and Safety of Sitafloxacin in Adult Subjects With Acute Exacerbation of Chronic Obstructive Pulmonary Disease |
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| Completed | 4 | 140 | RoW | Sitafloxacin, Gracevit, Moxifloxacin Hydrochloride, Avelox | Daiichi Sankyo | COPD Exacerbation Acute | 09/24 | 09/24 | | |
TrEAT_TD2, NCT05677282: Single Dose Antibiotic Treatment of Acute Watery Diarrhea, Rifaximin Versus Azithromycin, with Loperamide Adjunct |
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| Recruiting | 4 | 150 | RoW | Rifaximin 550 MG, Azithromycin 500 MG, Loperamide | Henry M. Jackson Foundation for the Advancement of Military Medicine, Infectious Diseases Clinical Research Program, Uniformed Services University of the Health Sciences | Diarrhoea;Acute, Diarrhea Travelers | 09/25 | 12/25 | | |
NCT06397781: Effect of S. Aureus Skin Decolonization on Disease Severity in Atopic Dermatitis Patients |
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| Not yet recruiting | 4 | 100 | US | Skin Cleanser Combination No.1 | Boston Children's Hospital | Atopic Dermatitis | 12/28 | 12/28 | | |
NCT06793358: Use of Remimazolam and Fentanyl for Procedural Sedation in Patients Undergoing Dental Extraction |
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| Not yet recruiting | 4 | 40 | US | fentanyl and Remimazolam | Indiana University, Indiana University Health | Dental Extraction | 01/26 | 03/26 | | |
POUR, NCT04994431: Post-Operative Urinary Retention () in Thoracic Surgery Patients Receiving Prophylactic Tamsulosin |
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| Terminated | 4 | 109 | US | Tamsulosin Hydrochloride | University of Massachusetts, Worcester, UMass Memorial Health Care | Thoracic Diseases, Urinary Retention | 10/23 | 10/23 | | |
NCT02932410 / 2016-001062-28: A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH) |
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| Active, not recruiting | 3 | 165 | Europe, Canada, US, RoW | Macitentan, ACT-064992, Standard-of-care | Actelion | Pulmonary Arterial Hypertension | 08/24 | 07/25 | | |
| Active, not recruiting | 3 | 590 | Europe, Canada, Japan, US, RoW | DS-1062a, Datopotamab deruxtecan (Dato-DXd), Docetaxel | Daiichi Sankyo, AstraZeneca | Non-small Cell Lung Cancer | 05/24 | 06/25 | | |
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IDeate-Lung02, NCT06203210: A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer |
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| Recruiting | 3 | 540 | Europe, Canada, Japan, US, RoW | Ifinatamab deruxtecan, I-DXd, Topotecan, Amrubicin, Lurbinectedin | Daiichi Sankyo, Merck Sharp & Dohme LLC | Small Cell Lung Cancer | 04/27 | 02/29 | | |
TNX-N, NCT03503136: Nedaplatin Versus Cisplatin and Capecitabine Versus Fluorouracil in IC + CCRT for Locoregionally Advanced NPC |
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| Not yet recruiting | 3 | 632 | RoW | docetaxel, nedaplatin, and capecitabine, TNX induction chemotherapy, nedaplatin, N, docetaxel, cisplatin, and fluorouracil, TPF induction chemotherapy, cisplatin, P, docetaxel, cisplatin, and capecitabine, TPX induction chemotherapy, docetaxel, nedaplatin, and fluorouracil, TNF induction chemotherapy | Sun Yat-sen University, Tongji Hospital, Wuhan Union Hospital, China, Peking University, Air Force Military Medical University, China, Second Affiliated Hospital of Soochow University, The First Affiliated Hospital of Guangdong Pharmaceutical University, First People's Hospital of Foshan, Fifth Affiliated Hospital, Sun Yat-Sen University, Cancer Hospital of Guizhou Province, Xiangya Hospital of Central South University, Jilin Provincial Tumor Hospital, Henan Cancer Hospital, Hunan Cancer Hospital, Cancer Hospital of Guangxi Medical University, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Zhejiang Cancer Hospital | Nasopharyngeal Carcinoma | 06/24 | 06/26 | | |
NCT05839899: Mifepristone and Misoprostol for Undesired Pregnancy of Unknown Location |
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| Recruiting | 3 | 50 | US | Mifepristone plus one dose Misoprostol, Mifepristone plus two doses Misoprostol | Planned Parenthood League of Massachusetts | Abortion | 07/24 | 09/24 | | |
| Active, not recruiting | 3 | 586 | Europe, Canada, Japan, US, RoW | Patritumab Deruxtecan, HER3-DXd, U3-1402, Platinum-based chemotherapy | Daiichi Sankyo, Merck Sharp & Dohme LLC | Nonsquamous Non-small Cell Lung Cancer, EGFR L858R, EGFR Exon 19 Deletion | 05/24 | 06/26 | | |
CYPRESS, NCT05696717: Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic NOH in Participants with Multiple System Atrophy |
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| Recruiting | 3 | 102 | Europe, Canada, US, RoW | Ampreloxetine, TD-9855, Placebo | Theravance Biopharma | Symptomatic Neurogenic Orthostatic Hypotension, MSA - Multiple System Atrophy | 12/24 | 01/27 | | |
NCT06672016: Study to Evaluate Contraceptive Efficacy and Safety of a Progestin Only Patch in Women of Childbearing Potential |
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| Not yet recruiting | 3 | 1500 | US | Transdermal system containing progestin | Mylan Pharmaceuticals Inc | Female Contraception | 03/27 | 04/27 | | |
| Not yet recruiting | 3 | 615 | RoW | Recombinant Humanized Anti-interleukin-6 Receptor Monoclonal Antibody Injection | Beijing VDJBio Co., LTD. | Rheumatoid Arthritis (RA) | 12/25 | 12/26 | | |
LIBERTY, NCT06716814: Study to Provide Continued Access to Treatment for Patients Completing a Previous Trial With Efanesoctocog Alfa |
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| Not yet recruiting | 3 | 78 | Europe | Efanesoctocog alfa, BIVV001, Altuvoct, Altuviiio, Recombinant coagulation factor VIII Fc-von-Willebrand Factor-XTEN fusion protein (rFVIIIFc-VWF-XTEN) | Swedish Orphan Biovitrum, PSI CRO | Severe Haemophilia A | 08/26 | 08/26 | | |
| Active, not recruiting | 3 | 899 | Europe, Canada, Japan, US, RoW | Tafasitamab, Monjuvi, Lenalidomide, Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, Tafasitamab placebo, Lenalidomide placebo | Incyte Corporation | Diffuse Large B-cell Lymphoma | 06/25 | 05/26 | | |
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| Completed | 3 | 1 | US | StrataGraft | Stratatech, a Mallinckrodt Company, Biomedical Advanced Research and Development Authority | Skin Wound, Burns, Trauma-related Wound | 05/24 | 05/24 | | |
| Active, not recruiting | 3 | 490 | Europe, Japan, RoW | Trastuzumab deruxtecan, T-DXd, DS-8201a, ENHERTU®, Ramucirumab, CYRAMZA®, Paclitaxel | Daiichi Sankyo, AstraZeneca | Gastric Cancer, Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma | 10/25 | 02/26 | | |
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NCT05847348: 68Ga-PSMA-11 Efficacy in Detecting BCR Prostate Cancer in Chinese Patients |
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| Recruiting | 3 | 110 | RoW | 68Ga-PSMA-11, Illucix, gallium Ga 68 Gozetotide, PET/CT or PET/MRI, Imaging by PET | Telix Pharmaceuticals (Innovations) Pty Limited, Grand Pharmaceutical (China) Co., Ltd. | Biochemical Recurrence of Malignant Neoplasm of Prostate, Prostate Cancer, BCR Prostate Carcinoma | 12/25 | 07/26 | | |
| Active, not recruiting | 3 | 1600 | Europe, Canada, Japan, US, RoW | DS-8201a, Trastuzumab deruxtecan (T-DXd), T-DM1, Trastuzumab emtansine (T-DM1) | Daiichi Sankyo, AstraZeneca, NSABP Foundation Inc, German Breast Group, Spanish Breast Cancer Research Group (SOLTI) | HER2-Positive Primary Breast Cancer, Residual Invasive Breast Cancer | 12/25 | 12/30 | | |
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FREEDOM, NCT05817812: A Study Evaluating Physical Activity and Joint Health in Severe Haemophilia A Patients ≥12 Years Treated Once Weekly With Efanesoctocog Alfa |
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| Active, not recruiting | 3 | 93 | Europe, RoW | Efanesoctocog alfa, BIVV001 | Swedish Orphan Biovitrum, Syneos Health | Hemophilia A, Severe | 05/26 | 05/26 | | |
TROPION-Lung07, NCT05555732: Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer |
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| Recruiting | 3 | 1170 | Europe, Canada, Japan, US, RoW | Datopotamab Deruxtecan, Dato-DXd, Pembrolizumab, KEYTRUDA®, Pemetrexed, Alimta, Pemfexy, Carboplatin, Cisplatin | Daiichi Sankyo, AstraZeneca, Merck Sharp & Dohme LLC | Metastatic Non Small Cell Lung Cancer | 08/27 | 08/27 | | |
DESTINY-Breast15, NCT05950945: Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer |
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| Recruiting | 3 | 250 | Europe, US, RoW | Trastuzumab Deruxtecan, T-DXd, DS-8201a (trastuzumab derextecan), Enhertu® | Daiichi Sankyo, AstraZeneca | Breast Cancer | 10/27 | 10/27 | | |
| Recruiting | 3 | 740 | Europe, Canada, Japan, US, RoW | Datopotamab Deruxtecan, Dato-DXd, Pembrolizumab, KEYTRUDA® | Daiichi Sankyo, AstraZeneca, Merck Sharp & Dohme LLC | Metastatic Non Small Cell Lung Cancer | 02/28 | 04/28 | | |
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ARTEMIS, NCT04797884: Electromagnetic Fields Versus Placebo For Child-Pugh A and B Patients With Advanced Hepatocellular Carcinoma |
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| Recruiting | 2/3 | 166 | US | TheraBionic Device, Placebo Device, Quality of Life Assessment | THERABIONIC INC., National Cancer Institute (NCI) | Hepatocellular Carcinoma | 10/24 | 10/24 | | |
FORTIFI-HN01, NCT06788990: a Study of Ficerafusp Alfa (BCA101) or Placebo in Combination with Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC |
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| Recruiting | 2/3 | 650 | US | Ficerafusp alfa, Pembrolizumab (KEYTRUDA®), Placebo | Bicara Therapeutics | Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma | 04/28 | 07/29 | | |
TRIPHASE, NCT06101745: Trial to Visualize the Ureters With Nizaracianine Triflutate in Adults Undergoing Abdominopelvic Surgery |
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| Recruiting | 2/3 | 336 | Europe | Nizaracianine Triflutate, ZW800-1, Placebo Comparator, Sugar | Curadel Surgical Innovations, Inc., Leiden University Medical Center, Erasmus Medical Center | Injury of Ureter During Surgery (Disorder) | 10/25 | 11/25 | | |
| Terminated | 2 | 16 | Europe, Canada, US, RoW | Belcesiran, Placebo | Dicerna Pharmaceuticals, Inc., a Novo Nordisk company | Alpha 1-Antitrypsin Deficiency | 12/23 | 05/24 | | |
AAVIATE, NCT04514653: RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD) |
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| Recruiting | 2 | 115 | US | Ranibizumab, RGX-314 Dose 1, Combination Product, RGX-314 Dose 2, RGX-314 Dose 3, Local Steroid, Topical Steroid | AbbVie, AbbVie | Neovascular Age-Related Macular Degeneration (nAMD) | 10/25 | 08/26 | | |
| Completed | 2 | 60 | US | RGX-314 | AbbVie | Neovascular Age-related Macular Degeneration, Wet Macular Degeneration, Wet Age-related Macular Degeneration | 10/23 | 03/24 | | |
Orchid 1, NCT06132919: Efficacy and Safety of MC2-25 Cream & Vehicle in Women With Vulvar Lichen Sclerosus (VLS) |
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| Recruiting | 2 | 40 | Europe | MC2-25 cream, MC2-25 vehicle | MC2 Therapeutics | Vulvar Lichen Sclerosus | 11/24 | 11/24 | | |
| Completed | 2 | 13 | US | AG Tx, Meshed Autograft, SOMA Tx, StrataGraft skin tissue Overlay of Meshed Autograft (SOMA) | Stratatech, a Mallinckrodt Company | Full Thickness Thermal Burn | 03/24 | 03/24 | | |
| Recruiting | 2 | 400 | Europe, Japan, US, RoW | HER3-DXd, Patritumab Deruxtecan, U3-1402 | Daiichi Sankyo, Merck Sharp & Dohme LLC | Advanced Solid Tumor, Melanoma, Head and Neck Cancer, Gastric Cancer, Ovarian Carcinoma, Cervical Cancer, Endometrial Cancer, Bladder Cancer, Esophageal Cancer, Pancreatic Carcinoma, Prostate Cancer | 06/25 | 04/26 | | |
NCT05198310 / 2022-000169-42: Study to Assess the Safety, Pharmacokinetics, and Efficacy of KPL-404 in Participants With Rheumatoid Arthritis With Inadequate Response or Intolerance to at Least One Biologic Disease-modifying Anti-rheumatic Drug or a Janus Kinase Inhibitor |
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| Completed | 2 | 145 | Europe, US, RoW | KPL-404, Placebo | Kiniksa Pharmaceuticals, Ltd., Kiniksa Pharmaceuticals, Ltd. | Arthritis, Rheumatoid | 02/24 | 05/24 | | |
| Recruiting | 2 | 90 | US | Hydroxypropyl Beta Cyclodextrin, Trappsol Cyclo, Placebo, 0.5N saline | Cyclo Therapeutics, Inc., Cyclo Therapeutics Inc. | Alzheimer's Disease | 03/24 | 03/24 | | |
| Completed | 2 | 65 | Europe, US | DS-1211b, Placebo | Daiichi Sankyo, PXE International | Pseudoxanthoma Elasticum | 11/23 | 11/23 | | |
IDeate-PanTumor02, NCT06330064: A Study To Evaluate The Efficacy And Safety Of Ifinatamab Deruxtecan (I-DXd) In Subjects With Recurrent Or Metastatic Solid Tumors |
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| Recruiting | 2 | 520 | Europe, Japan, US, RoW | Ifinatamab deruxtecan, I-DXd | Daiichi Sankyo, Merck Sharp & Dohme LLC | Recurrent or Metastatic Solid Tumors | 07/28 | 07/28 | | |
MAST, NCT06355583: Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant () Trial |
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| Not yet recruiting | 2 | 50 | Europe | EBX-102, IMT capsules, Placebo | Imperial College London | Acute Lymphoblastic Leukaemia, Acute Leukemia of Ambiguous Lineage, Chronic Myeloid Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndrome, Acute Myeloid Leukemia | 02/26 | 05/27 | | |
NCT04870905: Tisleilizumab (PD-1 Antibody) and Chemoradiotherapy in Locoregionally-advanced Nasopharyngeal Carcinoma |
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| Not yet recruiting | 2 | 100 | RoW | Tis-U-Sol | Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Union hospital of Fujian Medical University, Zhujiang Hospital, Guangdong Provincial People's Hospital | Nasopharyngeal Neoplasms | 05/24 | 05/26 | | |
| Active, not recruiting | 2 | 187 | Europe, Japan, US, RoW | Ifinatamab Deruxtecan (I-DXd), DS-7300a | Daiichi Sankyo, Merck Sharp & Dohme LLC | Extensive-stage Small-cell Lung Cancer | 01/25 | 04/25 | | |
| Recruiting | 2 | 32 | RoW | SPG302, Placebo | Spinogenix | Schizophrenia | 06/25 | 10/25 | | |
CBeyond, NCT06577090: Study to Evaluate the Effect on Obesity of Once Weekly Nimacimab Injection and Once Weekly Nimacimab Injection Co-administered With Semaglutide Injection Versus Placebo |
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| Recruiting | 2 | 120 | US | Nimacimab injection, Nimacimab placebo injection, semaglutide injection | Skye Bioscience, Inc., Bird Rock Bio Sub, Inc. | Obesity | 08/25 | 01/26 | | |
NCT05029336: Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases |
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| Recruiting | 2 | 20 | US | Depletion of CD3/CD19 in an autologous stem cell transplant, CD3/CD19 depletion using cliniMACs device | Stephan Grupp MD PhD | Systemic Lupus Erythematosus, Systemic Sclerosis | 12/26 | 05/31 | | |
| Recruiting | 2 | 64 | US | Bevonescein, ALM-488 | Alume Biosciences, Inc. | Surgery, Nerve Injury, Imaging | 06/25 | 09/25 | | |
NCT04935762: A Study of CST-103 Co-administered With CST-107 in Subjects With Parkinson's Disease Having Freezing of Gait (CLIN-012) |
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| Withdrawn | 2 | 25 | RoW | CST-103, CST-107, matching placebo | CuraSen Therapeutics, Inc. | Freezing of Gait Symptoms in Parkinson's Disease | 12/24 | 03/25 | | |
| Not yet recruiting | 2 | 200 | Japan, US | Raludotatug deruxtecan, R-DXd | Daiichi Sankyo, Merck Sharp & Dohme LLC | Advanced Solid Tumor, Metastatic Solid Tumors | 09/27 | 09/27 | | |
NCT04977024: SARS-CoV-2 Vaccine (GEO-CM04S1) Versus mRNA SARS-COV-2 Vaccine in Patients With Blood Cancer |
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| Recruiting | 2 | 240 | US | COVID-19 Vaccine, Diagnostic Laboratory Biomarker Analysis, Synthetic MVA-based SARS-CoV-2 Vaccine GEO-CM04S1, COH04S1, SARS-CoV-2 Vaccine COH04S1, sMVA-based SARS-CoV-2 Vaccine COH04S1, GEO-CM04S1 | GeoVax, Inc., National Cancer Institute (NCI) | COVID-19 Infection, Hematopoietic and Lymphoid System Neoplasm, Leukemia, Lymphoma, Plasma Cell Myeloma | 12/26 | 12/27 | | |
STEP, NCT06594393: A Phase 2 Study of TCP-25 Gel in Patients with Epidermolysis Bullosa, -study |
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| Not yet recruiting | 2 | 26 | Europe | TCP-25 gel, Vehicle (placebo) | Xinnate AB | Epidermolysis Bullosa (EB) | 06/26 | 06/26 | | |
NCT06038578: A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer |
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| Recruiting | 2 | 146 | Japan, US, RoW | TRK-950, Ramucirumab, CYRAMZA®, Paclitaxel | Toray Industries, Inc | Gastric Adenocarcinoma, Gastric Cancer, Gastroesophageal Junction Adenocarcinoma | 08/25 | 08/25 | | |
| Recruiting | 1/2 | 55 | Europe | CR6086, vorbipiprant, AGEN2034, balstilimab | Rottapharm Biotech, Agenus Inc. | Refractory Metastatic Colorectal Cancer, Solid Tumor, Metastatic Microsatellite-stable Colorectal Cancer, Mismatch Repair Protein Proficient, Metastatic GI Cancers, Gastric Cancer | 03/25 | 09/26 | | |
NCT05638802: A Study of DS-7011a in Patients With Systemic Lupus Erythematosus |
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| Active, not recruiting | 1/2 | 26 | US | DS-7011a, Placebo | Daiichi Sankyo | Systemic Lupus Erythematosus | 04/25 | 04/25 | | |
| Active, not recruiting | 1/2 | 190 | Europe, US | ASTX029 | Taiho Oncology, Inc. | Solid Tumor, Adult | 08/24 | 12/25 | | |
NCT05979831: A Study to Explore Safety, Pharmacokinetics, and Early Clinical Signal of Efficacy of DS-2325a in Patients With Netherton Syndrome |
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| Active, not recruiting | 1/2 | 9 | Europe | DS-2325a, Placebo | Daiichi Sankyo | Netherton Syndrome | 01/25 | 01/25 | | |
IDeate-Lung03, NCT06362252: A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer |
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| Recruiting | 1/2 | 123 | Europe, Japan, US | Ifinatamab deruxtecan, I-DXd, Atezolizumab, Carboplatin | Daiichi Sankyo, Merck Sharp & Dohme LLC | Extensive Stage-small Cell Lung Cancer | 09/26 | 12/26 | | |
| Recruiting | 1/2 | 145 | US, RoW | SQ3370 | Shasqi, Inc. | Cancer | 08/24 | 07/26 | | |
| Recruiting | 1/2 | 250 | Japan, US | Ifinatamab deruxtecan (I-DXd) | Daiichi Sankyo, Merck Sharp & Dohme LLC | Advanced Solid Tumor, Malignant Solid Tumor | 12/25 | 03/27 | | |
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| Active, not recruiting | 1/2 | 666 | Europe, Canada, US, RoW | Epcoritamab, GEN3013, DuoBody®-CD3xCD20, EPKINLY™ | Genmab, AbbVie | DLBCL, High-grade B-cell Lymphoma (HGBCL), Primary Mediastinal Large B-cell Lymphoma (PMBCL), FL, MCL, Small Lymphocytic Lymphoma (SLL), Marginal Zone Lymphoma (MZL) | 03/25 | 01/29 | | |
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| Not yet recruiting | 1/2 | 42 | US | RXRG001, Placebo | RiboX Therapeutics Ltd. | Radiation-Induced Xerostomia and Hyposalivation | 08/27 | 08/27 | | |
NCT05693025: Evaluation of the Walk With Ease Program for Fall Prevention |
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| Recruiting | 1/2 | 240 | US | Group Exercise, Behavioral Training | Iowa State University | Exercise, Frailty, Arthritis, Accidental Falls | 05/25 | 05/26 | | |
| Recruiting | 1/2 | 430 | Europe, Japan, US | DS-3939a | Daiichi Sankyo | Advanced Solid Tumor, Metastatic Solid Tumor | 03/26 | 07/27 | | |
NCT03793478 / 2016-002919-18: Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood |
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| Active, not recruiting | 1/2 | 65 | Europe, Canada, US, RoW | Quizartinib, Quizartinib dihydrochloride, Vanflyta, Fludarabine, Cytarabine, Intrathecal (IT) triple chemotherapy prophylaxis, Etoposide | Daiichi Sankyo, Innovative Therapies For Children with Cancer Consortium, Children's Oncology Group | Acute Myeloid Leukemia | 05/27 | 05/27 | | |
