Unversity of Calgary
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 58 Trials 
69 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Sheldon, Robert S
NCT02123056: Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects

Active, not recruiting
4
52
Canada
Metoprolol, Lopressor, Toprol-XL, Mteprolol Succinate ER, Matching Placebo
University of Calgary, Vanderbilt University
Vasovagal Syncope
03/21
12/25
AAA, NCT04594746: Oral Amiodarone for Acute Cardioversion of Atrial Fibrillation Study

Recruiting
4
42
Canada
Amiodarone Hydrochloride, Cordarone, Nexterone, Placebo, Sugar Pill
University of Calgary
Atrial Fibrillation
12/27
12/27
POST7, NCT05159687: Study of Atomoxetine in the Prevention of Vasovagal Syncope

Recruiting
3
180
Canada
Atomoxetine Hydrochloride, Placebo
University of Calgary
Vasovagal Syncope
09/26
09/27
POST 9, NCT05657925: Study of Ondansetron in the Prevention of Sleep Syncope: The Nineth Prevention of Syncope Trial (POST9)

Not yet recruiting
3
24
Canada
ondansetron 8 mg, Matching placebo
University of Calgary
Sleep Syncope
12/26
12/27
POST 11, NCT05755737: A Proof of Principle Study of Ondansetron for the Prevention of Vasovagal Syncope: The Eleventh Prevention of Syncope Trial (POST11)

Recruiting
2
70
Canada
Ondansetron, Placebo
University of Calgary
Vasovagal Syncope (VVS), Syncope
12/25
12/26
NCT02673996: POTS Adrenergic Ab (CIHR Aims #1&2)

Recruiting
N/A
125
Canada
Phenylephrine, NeoSynephrine, Isoproterenol, Isuprel
University of Calgary
Postural Tachycardia Syndrome
12/26
12/27
Pacing_SV, NCT03446326: Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates

Recruiting
N/A
25
Canada
Pacing
University of Calgary
Vasovagal Syncope
01/27
01/28
NCT04347655: Assessing Systemic Circulation and LV Performance in Adults

Recruiting
N/A
100
Canada
handgrip test
University of Calgary
Heart Failure
12/25
12/26
NCT05295810: Hypercapnia in Orthostatic Hypotension

Recruiting
N/A
80
Canada
Sequential Gas Delivery
University of Calgary
Orthostatic Hypotension, Neurogenic Orthostatic Hypotension
12/26
05/27
NCT04271878: Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome

Recruiting
N/A
26
Canada
RespirAct™ system (Thornhill Research Inc., Toronto, Canada)
University of Calgary
Postural Tachycardia Syndrome, Orthostatic Intolerance
12/26
12/26
NCT05908760: CO2 Rebreathing in nOH: A Proof-of-Concept Pilot Study

Recruiting
N/A
28
Canada
CO2 ReHaler
University of Calgary
Neurogenic Orthostatic Hypotension, Autonomic Failure
12/27
12/28
POST10, NCT05776810: Syncope Trial to Understand Tilt Testing or ECG Recording Tenth Prevention of Syncope Trial

Recruiting
N/A
144
Canada
Diagnostic Test: Head Up Tilt Table (HUT), Device: Implantable Loop Recorder
University of Calgary
Syncope
12/26
12/26
NCT05914649: NC Testing in LC & POTS

Recruiting
N/A
100
Canada
IV normal saline (999 mL infusion), IV normal saline (50 mL infusion)
University of Calgary
Postural Orthostatic Tachycardia Syndrome, Post Acute Sequelae of SARS CoV 2 Infection
12/28
12/29
Sigal, Ronald J
TRANSCEND-T2D-2, NCT06260722: Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor

Active, not recruiting
3
1250
Canada, US, RoW
Retatrutide, LY3437943, Semaglutide
Eli Lilly and Company
Diabetes Mellitus, Type 2
08/26
01/27
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

Recruiting
3
150
Canada, US
Sotagliflozin, INPEFA, Placebo
Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D
Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
12/28
05/29
NCT04348630: Establishing Evidence-based Indoor Temperature Thresholds to Protect Health

Completed
N/A
16
Canada
Simulated heatwave exposure
University of Ottawa
Aging, Heat Stress, Physiological Stress
11/21
11/21
NCT05695079: Efficacy of Electric Fans for Mitigating Thermal Strain in Older Adults During Heat Waves

Completed
N/A
19
Canada
No cooling (control), Electric fan (low airflow), Electric fan (high airflow)
University of Ottawa
Hyperthermia, Weather; Heat, Heat Stress, Aging
04/23
04/23
NCT05601713: Mitigating Heat-induced Physiological Strain and Discomfort in Older Adults Via Lower Limb Immersion and Neck Cooling

Completed
N/A
18
Canada
No cooling (control), Lower limb immersion, Lower limb immersion + neck cooling
University of Ottawa
Hyperthermia, Weather; Heat, Heat Stress, Heat Syncope, Aging
05/23
05/23
NCT05274009: Protective Cooling Measures to Safeguard Elderly People From Dangerous Summer Heat

Not yet recruiting
N/A
60
Canada
No cooling (control), Recommended cooling, Hybrid cooling
University of Ottawa
Hyperthermia, Heat; Weather, Aging, Type2 Diabetes, Hypertension, Heat Stress
05/24
05/24
Raj, Satish
NCT05603741: Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

Active, not recruiting
4
155
Canada
0.9% Sodium Chloride Injection, Saline, Lidocaine Injection 2%, Xylocaine, Lignocaine
University of Calgary, Vanderbilt University Medical Center
Ehlers-Danlos Syndrome, Anesthesia, Local
01/27
06/27
AAA, NCT04594746: Oral Amiodarone for Acute Cardioversion of Atrial Fibrillation Study

Recruiting
4
42
Canada
Amiodarone Hydrochloride, Cordarone, Nexterone, Placebo, Sugar Pill
University of Calgary
Atrial Fibrillation
12/27
12/27
NCT05363514: Low Dose Naltrexone Use in Patients With POTS

Not yet recruiting
4
80
NA
Low Dose Naltrexone, LDN, Microcrystalline cellulose, Placebo
University of Calgary
Postural Orthostatic Tachycardia Syndrome
06/28
12/28
NCT04186286: Crossover Study of Propranolol vs Ivabradine in POTS

Recruiting
2
20
Canada
Ivabradine 4-week course, Lancora, Propranolol 4-week course, Inderal, Placebo 4-week course
University of Calgary, Dysautonomia International
Postural Tachycardia Syndrome
12/25
12/26
NCT00262470: Treatment of Orthostatic Intolerance

Active, not recruiting
1/2
150
US
Acetazolamide, Diamox, Atomoxetine, Strattera, NO Drug, Clonidine, Catapres, Entacapone, Comtan, Entacapone & Propranolol, Inderal, Atomoxetine & Propranolol, Indomethacin, Indocin, Mecamylamine, inversine, Isosorbide Dinitrate, Isordil, Melatonin, Midodrine, pro-amatine, Modafinil, provigil, Octreotide, sandostatin, Placebo, Propranolol, Modafinil & Propranolol, Provigil, Sertraline, Zoloft, IV Saline, NaCl solution (0.9%), Drinking Water, Breathing Device, memantine, Namenda, Abdominal binder
Satish R. Raj, National Center for Advancing Translational Sciences (NCATS)
Tachycardia, Chronic Orthostatic Intolerance
12/27
12/27
COM-COM-POTS, NCT04881318: Compression Garments in the Community With POTS

Recruiting
N/A
30
Canada
Waist-High Compression Tights, Abdominal Compression Garments, Abdominal shapewear, compression shorts, Medications that modulate heart rate and blood pressure
University of Calgary
Postural Orthostatic Tachycardia Syndrome
12/24
12/24
NCT00962728: Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)

Active, not recruiting
N/A
30
US
Inspiratory Threshold Device (Res-Q-Gard ITD), Res-Q-Gard ITD device 7.0 (Ref:12-0463-000), Sham Inspiratory Threshold Device, Model 002850P, Sims Portex Inc, Keene NH
Alfredo Gamboa, Vanderbilt University Medical Center
Postural Tachycardia Syndrome, Postural Orthostatic Tachycardia Syndrome
11/25
12/25
IOH, NCT03970551: Lower Body Muscle Pre-activation in Initial Orthostatic Hypotension

Active, not recruiting
N/A
64
Canada
Physical Counter-maneuver, Stress Test, Cold Pressor Test, Serial 7's Stress Test, Functional Electrical Stimulation
University of Calgary
Orthostatic Intolerance, Syncope, Fainting, Presyncope
12/23
12/23
NCT02673996: POTS Adrenergic Ab (CIHR Aims #1&2)

Recruiting
N/A
125
Canada
Phenylephrine, NeoSynephrine, Isoproterenol, Isuprel
University of Calgary
Postural Tachycardia Syndrome
12/26
12/27
NCT01000350: Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)

Active, not recruiting
N/A
40
US
Saline, Normal Saline, 0.9% saline, Placebo
Vanderbilt University Medical Center
Postural Tachycardia Syndrome
06/28
06/28
RPM CIED Tachy, NCT03405740: Remote Patient Management of CIEDs

Recruiting
N/A
1164
Canada
Remote Patient Management, Standard of Care
Ratika Parkash, Cardiac Arrhythmia Network of Canada, Abbott Medical Devices, Medtronic
Cardiac Arrhythmia
02/25
06/25
NCT03636230: Remote Patient Management of CIEDs - Brady Devices

Recruiting
N/A
848
Canada
Remote Monitoring, Standard of care
Ratika Parkash, Cardiac Arrhythmia Network of Canada, Medtronic, Abbott
Pacemaker
02/25
06/25
Pacing_SV, NCT03446326: Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates

Recruiting
N/A
25
Canada
Pacing
University of Calgary
Vasovagal Syncope
01/27
01/28
CO2-nOH, NCT06751888: Controlled CO2 Inhalation in NOH

Not yet recruiting
N/A
28
Canada
Controlled CO2 delivery, Controlled CO2 delivery (Sham)
University of Calgary
Neurogenic Orthostatic Hypotension
12/28
12/28
NCT04391465: Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate

Recruiting
N/A
20
Canada
Electrophysiological Pacing
University of Calgary
Cerebrovascular Circulation, Physiology
06/26
06/27
NCT02196376: Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome

Active, not recruiting
N/A
212
US
History, Physical, blood draw, Questionnaires
Vanderbilt University
Postural Orthostatic Tachycardia Syndrome
07/27
07/27
NCT00608725: Pathophysiology of Orthostatic Intolerance

Active, not recruiting
N/A
260
US
DAXOR, Volumex, QSweat, QSART, Quantitative Axonal Sudomotor Reflex Testing, Intrinsic Heart Rate, Inderal, IHR
Satish R. Raj, National Institutes of Health (NIH)
Tachycardia, Postural Orthostatic Tachycardia Syndrome
12/27
12/27
NCT00581321: Oral Water Ingestion in Heart Transplant Patients

Active, not recruiting
N/A
40
US
water
Satish R. Raj, National Center for Research Resources (NCRR)
Blood Pressure, Cardiac Transplantation
12/27
12/27
NCT00580996: Water and the Gastropressor Response - Tachyphylaxis

Active, not recruiting
N/A
20
US
water high dose, water tiny dose
Satish R. Raj
Orthostatic Hypotension
12/27
12/27
NCT00581633: Acute Salt Handling in Orthostatic Intolerance

Active, not recruiting
N/A
30
US
normal saline (0.9%)
Vanderbilt University, National Center for Research Resources (NCRR), National Heart, Lung, and Blood Institute (NHLBI)
Postural Tachycardia Syndrome, Orthostatic Tachycardia, Orthostatic Intolerance
12/27
12/27
NCT00581373: Water and the Gastropressor Response - Diurnal Variability

Active, not recruiting
N/A
20
US
water 16 fl oz
Satish R. Raj
Orthostatic Hypotension
12/27
12/27
NCT00692471: Sleep Actigraphy in Postural Tachycardia Syndrome (POTS)

Active, not recruiting
N/A
100
US
Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter, ActiWatch from Minimitter
Satish R. Raj, National Center for Research Resources (NCRR)
Postural Tachycardia Syndrome, Orthostatic Intolerance, Sleep Disorders
12/27
12/27
NCT03218761: POTS NET mRNA Functional Correlation With NET Activity

Active, not recruiting
N/A
200
US
NET mRNA level, Plasma catechols, Urine Catechols
Vanderbilt University Medical Center, National Institute of Neurological Disorders and Stroke (NINDS), University of Calgary, Dysautonomia International
Postural Tachycardia Syndrome
12/27
12/27
NCT04036305: Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

Enrolling by invitation
N/A
230
US
0.9% Sodium Chloride Injection, Saline, Lidocaine Injection 2%, Xylocaine, lignocaine, Bupivacaine Injection 0.5%, marcaine
Vanderbilt University Medical Center, University of Calgary
Ehlers-Danlos Syndrome, Anesthesia, Local
12/27
12/27
NCT04347655: Assessing Systemic Circulation and LV Performance in Adults

Recruiting
N/A
100
Canada
handgrip test
University of Calgary
Heart Failure
12/25
12/26
NCT05295810: Hypercapnia in Orthostatic Hypotension

Recruiting
N/A
80
Canada
Sequential Gas Delivery
University of Calgary
Orthostatic Hypotension, Neurogenic Orthostatic Hypotension
12/26
05/27
CASA-POTS, NCT05924646: CAlgary SAlt for POTS

Recruiting
N/A
50
Canada
Sodium Chloride Capsules, Microcystalline Cellulose Capsules
University of Calgary
Postural Orthostatic Tachycardia Syndrome
06/28
12/28
NCT04271878: Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome

Recruiting
N/A
26
Canada
RespirAct™ system (Thornhill Research Inc., Toronto, Canada)
University of Calgary
Postural Tachycardia Syndrome, Orthostatic Intolerance
12/26
12/26
NCT05908760: CO2 Rebreathing in nOH: A Proof-of-Concept Pilot Study

Recruiting
N/A
28
Canada
CO2 ReHaler
University of Calgary
Neurogenic Orthostatic Hypotension, Autonomic Failure
12/27
12/28
NCT05914649: NC Testing in LC & POTS

Recruiting
N/A
100
Canada
IV normal saline (999 mL infusion), IV normal saline (50 mL infusion)
University of Calgary
Postural Orthostatic Tachycardia Syndrome, Post Acute Sequelae of SARS CoV 2 Infection
12/28
12/29
NCT06048731: Enlighten Study: the EV-ICD Post Approval Registry

Active, not recruiting
N/A
1000
Europe, Canada, US, RoW
Defibrillation using EV-ICD
Medtronic
Ventricular Arrhythmia, Tachycardia
05/30
10/37
Pop-Busui, Rodica
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

Recruiting
3
150
Canada, US
Sotagliflozin, INPEFA, Placebo
Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D
Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
12/28
05/29
TINSAL-T1DN, NCT02936843: Targeting Inflammation With Salsalate in Type 1 Diabetes Neuropathy

Completed
2/3
61
US
Salsalate, disalcid, PLACEBO
University of Michigan
Type 1 Diabetes, Peripheral Neuropathy
05/23
05/23
PERL-FENO, NCT04929379: A Pilot Study of Fenofibrate to Prevent Kidney Function Loss in Type 1 Diabetes

Active, not recruiting
2
40
US
Fenofibrate, Placebo
Alessandro Doria, University of Michigan, University of Minnesota
Diabetic Nephropathies
05/25
08/25
NCT05169060: Omega-3 Fatty Acid Lipidomics in Diabetes Peripheral Neuropathy

Recruiting
1/2
100
US
Fish Oil Concentrate, 1000 Mg Oral Capsule, Salsalate Oral Tablet
University of Iowa, University of Michigan
Diabetic Neuropathies
07/25
01/26
NCT05200819: Incidence and Predictors of Acute and Chronic Complications in Patients With Diabetes and Severe COVID-19

Completed
N/A
70
US
University of Michigan
Covid19, Diabetes Mellitus
02/23
02/23
NCT04591691: C-myc Biomarker Study for Diabetic Foot Ulcers

Completed
N/A
140
US
University of Michigan, Indiana University, Stanford University, University of Miami, University of Pittsburgh, University of California, San Francisco, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes, Diabetic Foot, Diabetic Foot Ulcer, Diabetic Wound
07/23
07/23
NCT05328986: Kidney Disease After COVID-19

Active, not recruiting
N/A
3000
US
Icahn School of Medicine at Mount Sinai, New Jersey Medical School, University of Michigan, Yale New Haven Health System Center for Healthcare Solutions, Johns Hopkins University
COVID-19, Acute Kidney Injury, Chronic Kidney Injury
01/25
01/25
NCT02748018: Multi-center Trial in Adult and Pediatric Patients With Type 1 Diabetes Using Hybrid Closed Loop System and Control at Home

Active, not recruiting
N/A
280
Europe, Canada, US, RoW
670G and 770G Insulin Pump, Subject's Current Diabetes Therapy
Medtronic Diabetes
Type 1 Diabetes
04/25
06/25
NCT06104969: DFC 004 Biomarkers for Active Diabetic Foot Ulcers

Recruiting
N/A
5000
US
University of Michigan, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetic Foot Ulcer, Diabetic Foot, Diabetes
06/28
06/28
Doria, Alessandro
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

Recruiting
3
150
Canada, US
Sotagliflozin, INPEFA, Placebo
Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D
Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
12/28
05/29
PERL-FENO, NCT04929379: A Pilot Study of Fenofibrate to Prevent Kidney Function Loss in Type 1 Diabetes

Active, not recruiting
2
40
US
Fenofibrate, Placebo
Alessandro Doria, University of Michigan, University of Minnesota
Diabetic Nephropathies
05/25
08/25
McGill, Janet
NCT05541484: Ketone Monitoring in T1D: Effect of SGLT2i During Usual Care and With Insulin Deficiency

Completed
4
21
US
SGLT2 inhibitor, Dapagliflozin 10mg (Farxiga), Biosense Breath Ketone Analyzer
Washington University School of Medicine, Juvenile Diabetes Research Foundation
Diabetes Mellitus, Type 1
12/23
12/23
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

Recruiting
3
150
Canada, US
Sotagliflozin, INPEFA, Placebo
Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D
Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
12/28
05/29
DIAGNODE-3, NCT05018585 / 2021-002731-32: A Phase III Study to Investigate if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 Diabetes

Recruiting
3
330
Europe, US, RoW
Recombinant human glutamic acid decarboxylase (rhGAD65) formulated in Alhydrogel®, Diamyd, Colecalciferol 2000 IU, Divisun 2000 IU, Placebo
Diamyd Medical AB
Type 1 Diabetes Mellitus
12/27
12/27
NCT04887935: Neoadjuvant SGLT2 Inhibition in High-Risk Localized Prostate Cancer

Recruiting
1
24
US
Dapagliflozin, Farxiga
Washington University School of Medicine, The Foundation for Barnes-Jewish Hospital
Prostate Cancer, Cancer of Prostate
08/26
08/26
COMP-SR, NCT02122666: Composition & Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome

Completed
N/A
27
US
muscle biopsy
Washington University School of Medicine
Metabolic Syndrome
02/24
02/24
Bourne, Kate
COM-COM-POTS, NCT04881318: Compression Garments in the Community With POTS

Recruiting
N/A
30
Canada
Waist-High Compression Tights, Abdominal Compression Garments, Abdominal shapewear, compression shorts, Medications that modulate heart rate and blood pressure
University of Calgary
Postural Orthostatic Tachycardia Syndrome
12/24
12/24
Dunlop, Amy
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

Recruiting
3
150
Canada, US
Sotagliflozin, INPEFA, Placebo
Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D
Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
12/28
05/29
CIRCUIT, NCT04902378: Closed-loop Insulin Delivery In Type 1 Diabetes Pregnancies

Active, not recruiting
N/A
94
Canada, RoW
Tandem t:slim X2 insulin pump with Control IQ technology
University of Calgary
Type 1 Diabetes Mellitus, Pregnancy Related, Glucose Metabolism Disorders, Metabolic Disease, Endocrine System Diseases
01/25
03/25
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Sheldon, Robert S
NCT02123056: Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects

Active, not recruiting
4
52
Canada
Metoprolol, Lopressor, Toprol-XL, Mteprolol Succinate ER, Matching Placebo
University of Calgary, Vanderbilt University
Vasovagal Syncope
03/21
12/25
AAA, NCT04594746: Oral Amiodarone for Acute Cardioversion of Atrial Fibrillation Study

Recruiting
4
42
Canada
Amiodarone Hydrochloride, Cordarone, Nexterone, Placebo, Sugar Pill
University of Calgary
Atrial Fibrillation
12/27
12/27
POST7, NCT05159687: Study of Atomoxetine in the Prevention of Vasovagal Syncope

Recruiting
3
180
Canada
Atomoxetine Hydrochloride, Placebo
University of Calgary
Vasovagal Syncope
09/26
09/27
POST 9, NCT05657925: Study of Ondansetron in the Prevention of Sleep Syncope: The Nineth Prevention of Syncope Trial (POST9)

Not yet recruiting
3
24
Canada
ondansetron 8 mg, Matching placebo
University of Calgary
Sleep Syncope
12/26
12/27
POST 11, NCT05755737: A Proof of Principle Study of Ondansetron for the Prevention of Vasovagal Syncope: The Eleventh Prevention of Syncope Trial (POST11)

Recruiting
2
70
Canada
Ondansetron, Placebo
University of Calgary
Vasovagal Syncope (VVS), Syncope
12/25
12/26
NCT02673996: POTS Adrenergic Ab (CIHR Aims #1&2)

Recruiting
N/A
125
Canada
Phenylephrine, NeoSynephrine, Isoproterenol, Isuprel
University of Calgary
Postural Tachycardia Syndrome
12/26
12/27
Pacing_SV, NCT03446326: Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates

Recruiting
N/A
25
Canada
Pacing
University of Calgary
Vasovagal Syncope
01/27
01/28
NCT04347655: Assessing Systemic Circulation and LV Performance in Adults

Recruiting
N/A
100
Canada
handgrip test
University of Calgary
Heart Failure
12/25
12/26
NCT05295810: Hypercapnia in Orthostatic Hypotension

Recruiting
N/A
80
Canada
Sequential Gas Delivery
University of Calgary
Orthostatic Hypotension, Neurogenic Orthostatic Hypotension
12/26
05/27
NCT04271878: Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome

Recruiting
N/A
26
Canada
RespirAct™ system (Thornhill Research Inc., Toronto, Canada)
University of Calgary
Postural Tachycardia Syndrome, Orthostatic Intolerance
12/26
12/26
NCT05908760: CO2 Rebreathing in nOH: A Proof-of-Concept Pilot Study

Recruiting
N/A
28
Canada
CO2 ReHaler
University of Calgary
Neurogenic Orthostatic Hypotension, Autonomic Failure
12/27
12/28
POST10, NCT05776810: Syncope Trial to Understand Tilt Testing or ECG Recording Tenth Prevention of Syncope Trial

Recruiting
N/A
144
Canada
Diagnostic Test: Head Up Tilt Table (HUT), Device: Implantable Loop Recorder
University of Calgary
Syncope
12/26
12/26
NCT05914649: NC Testing in LC & POTS

Recruiting
N/A
100
Canada
IV normal saline (999 mL infusion), IV normal saline (50 mL infusion)
University of Calgary
Postural Orthostatic Tachycardia Syndrome, Post Acute Sequelae of SARS CoV 2 Infection
12/28
12/29
Sigal, Ronald J
TRANSCEND-T2D-2, NCT06260722: Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor

Active, not recruiting
3
1250
Canada, US, RoW
Retatrutide, LY3437943, Semaglutide
Eli Lilly and Company
Diabetes Mellitus, Type 2
08/26
01/27
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

Recruiting
3
150
Canada, US
Sotagliflozin, INPEFA, Placebo
Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D
Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
12/28
05/29
NCT04348630: Establishing Evidence-based Indoor Temperature Thresholds to Protect Health

Completed
N/A
16
Canada
Simulated heatwave exposure
University of Ottawa
Aging, Heat Stress, Physiological Stress
11/21
11/21
NCT05695079: Efficacy of Electric Fans for Mitigating Thermal Strain in Older Adults During Heat Waves

Completed
N/A
19
Canada
No cooling (control), Electric fan (low airflow), Electric fan (high airflow)
University of Ottawa
Hyperthermia, Weather; Heat, Heat Stress, Aging
04/23
04/23
NCT05601713: Mitigating Heat-induced Physiological Strain and Discomfort in Older Adults Via Lower Limb Immersion and Neck Cooling

Completed
N/A
18
Canada
No cooling (control), Lower limb immersion, Lower limb immersion + neck cooling
University of Ottawa
Hyperthermia, Weather; Heat, Heat Stress, Heat Syncope, Aging
05/23
05/23
NCT05274009: Protective Cooling Measures to Safeguard Elderly People From Dangerous Summer Heat

Not yet recruiting
N/A
60
Canada
No cooling (control), Recommended cooling, Hybrid cooling
University of Ottawa
Hyperthermia, Heat; Weather, Aging, Type2 Diabetes, Hypertension, Heat Stress
05/24
05/24
Raj, Satish
NCT05603741: Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

Active, not recruiting
4
155
Canada
0.9% Sodium Chloride Injection, Saline, Lidocaine Injection 2%, Xylocaine, Lignocaine
University of Calgary, Vanderbilt University Medical Center
Ehlers-Danlos Syndrome, Anesthesia, Local
01/27
06/27
AAA, NCT04594746: Oral Amiodarone for Acute Cardioversion of Atrial Fibrillation Study

Recruiting
4
42
Canada
Amiodarone Hydrochloride, Cordarone, Nexterone, Placebo, Sugar Pill
University of Calgary
Atrial Fibrillation
12/27
12/27
NCT05363514: Low Dose Naltrexone Use in Patients With POTS

Not yet recruiting
4
80
NA
Low Dose Naltrexone, LDN, Microcrystalline cellulose, Placebo
University of Calgary
Postural Orthostatic Tachycardia Syndrome
06/28
12/28
NCT04186286: Crossover Study of Propranolol vs Ivabradine in POTS

Recruiting
2
20
Canada
Ivabradine 4-week course, Lancora, Propranolol 4-week course, Inderal, Placebo 4-week course
University of Calgary, Dysautonomia International
Postural Tachycardia Syndrome
12/25
12/26
NCT00262470: Treatment of Orthostatic Intolerance

Active, not recruiting
1/2
150
US
Acetazolamide, Diamox, Atomoxetine, Strattera, NO Drug, Clonidine, Catapres, Entacapone, Comtan, Entacapone & Propranolol, Inderal, Atomoxetine & Propranolol, Indomethacin, Indocin, Mecamylamine, inversine, Isosorbide Dinitrate, Isordil, Melatonin, Midodrine, pro-amatine, Modafinil, provigil, Octreotide, sandostatin, Placebo, Propranolol, Modafinil & Propranolol, Provigil, Sertraline, Zoloft, IV Saline, NaCl solution (0.9%), Drinking Water, Breathing Device, memantine, Namenda, Abdominal binder
Satish R. Raj, National Center for Advancing Translational Sciences (NCATS)
Tachycardia, Chronic Orthostatic Intolerance
12/27
12/27
COM-COM-POTS, NCT04881318: Compression Garments in the Community With POTS

Recruiting
N/A
30
Canada
Waist-High Compression Tights, Abdominal Compression Garments, Abdominal shapewear, compression shorts, Medications that modulate heart rate and blood pressure
University of Calgary
Postural Orthostatic Tachycardia Syndrome
12/24
12/24
NCT00962728: Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)

Active, not recruiting
N/A
30
US
Inspiratory Threshold Device (Res-Q-Gard ITD), Res-Q-Gard ITD device 7.0 (Ref:12-0463-000), Sham Inspiratory Threshold Device, Model 002850P, Sims Portex Inc, Keene NH
Alfredo Gamboa, Vanderbilt University Medical Center
Postural Tachycardia Syndrome, Postural Orthostatic Tachycardia Syndrome
11/25
12/25
IOH, NCT03970551: Lower Body Muscle Pre-activation in Initial Orthostatic Hypotension

Active, not recruiting
N/A
64
Canada
Physical Counter-maneuver, Stress Test, Cold Pressor Test, Serial 7's Stress Test, Functional Electrical Stimulation
University of Calgary
Orthostatic Intolerance, Syncope, Fainting, Presyncope
12/23
12/23
NCT02673996: POTS Adrenergic Ab (CIHR Aims #1&2)

Recruiting
N/A
125
Canada
Phenylephrine, NeoSynephrine, Isoproterenol, Isuprel
University of Calgary
Postural Tachycardia Syndrome
12/26
12/27
NCT01000350: Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)

Active, not recruiting
N/A
40
US
Saline, Normal Saline, 0.9% saline, Placebo
Vanderbilt University Medical Center
Postural Tachycardia Syndrome
06/28
06/28
RPM CIED Tachy, NCT03405740: Remote Patient Management of CIEDs

Recruiting
N/A
1164
Canada
Remote Patient Management, Standard of Care
Ratika Parkash, Cardiac Arrhythmia Network of Canada, Abbott Medical Devices, Medtronic
Cardiac Arrhythmia
02/25
06/25
NCT03636230: Remote Patient Management of CIEDs - Brady Devices

Recruiting
N/A
848
Canada
Remote Monitoring, Standard of care
Ratika Parkash, Cardiac Arrhythmia Network of Canada, Medtronic, Abbott
Pacemaker
02/25
06/25
Pacing_SV, NCT03446326: Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates

Recruiting
N/A
25
Canada
Pacing
University of Calgary
Vasovagal Syncope
01/27
01/28
CO2-nOH, NCT06751888: Controlled CO2 Inhalation in NOH

Not yet recruiting
N/A
28
Canada
Controlled CO2 delivery, Controlled CO2 delivery (Sham)
University of Calgary
Neurogenic Orthostatic Hypotension
12/28
12/28
NCT04391465: Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate

Recruiting
N/A
20
Canada
Electrophysiological Pacing
University of Calgary
Cerebrovascular Circulation, Physiology
06/26
06/27
NCT02196376: Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome

Active, not recruiting
N/A
212
US
History, Physical, blood draw, Questionnaires
Vanderbilt University
Postural Orthostatic Tachycardia Syndrome
07/27
07/27
NCT00608725: Pathophysiology of Orthostatic Intolerance

Active, not recruiting
N/A
260
US
DAXOR, Volumex, QSweat, QSART, Quantitative Axonal Sudomotor Reflex Testing, Intrinsic Heart Rate, Inderal, IHR
Satish R. Raj, National Institutes of Health (NIH)
Tachycardia, Postural Orthostatic Tachycardia Syndrome
12/27
12/27
NCT00581321: Oral Water Ingestion in Heart Transplant Patients

Active, not recruiting
N/A
40
US
water
Satish R. Raj, National Center for Research Resources (NCRR)
Blood Pressure, Cardiac Transplantation
12/27
12/27
NCT00580996: Water and the Gastropressor Response - Tachyphylaxis

Active, not recruiting
N/A
20
US
water high dose, water tiny dose
Satish R. Raj
Orthostatic Hypotension
12/27
12/27
NCT00581633: Acute Salt Handling in Orthostatic Intolerance

Active, not recruiting
N/A
30
US
normal saline (0.9%)
Vanderbilt University, National Center for Research Resources (NCRR), National Heart, Lung, and Blood Institute (NHLBI)
Postural Tachycardia Syndrome, Orthostatic Tachycardia, Orthostatic Intolerance
12/27
12/27
NCT00581373: Water and the Gastropressor Response - Diurnal Variability

Active, not recruiting
N/A
20
US
water 16 fl oz
Satish R. Raj
Orthostatic Hypotension
12/27
12/27
NCT00692471: Sleep Actigraphy in Postural Tachycardia Syndrome (POTS)

Active, not recruiting
N/A
100
US
Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter, ActiWatch from Minimitter
Satish R. Raj, National Center for Research Resources (NCRR)
Postural Tachycardia Syndrome, Orthostatic Intolerance, Sleep Disorders
12/27
12/27
NCT03218761: POTS NET mRNA Functional Correlation With NET Activity

Active, not recruiting
N/A
200
US
NET mRNA level, Plasma catechols, Urine Catechols
Vanderbilt University Medical Center, National Institute of Neurological Disorders and Stroke (NINDS), University of Calgary, Dysautonomia International
Postural Tachycardia Syndrome
12/27
12/27
NCT04036305: Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

Enrolling by invitation
N/A
230
US
0.9% Sodium Chloride Injection, Saline, Lidocaine Injection 2%, Xylocaine, lignocaine, Bupivacaine Injection 0.5%, marcaine
Vanderbilt University Medical Center, University of Calgary
Ehlers-Danlos Syndrome, Anesthesia, Local
12/27
12/27
NCT04347655: Assessing Systemic Circulation and LV Performance in Adults

Recruiting
N/A
100
Canada
handgrip test
University of Calgary
Heart Failure
12/25
12/26
NCT05295810: Hypercapnia in Orthostatic Hypotension

Recruiting
N/A
80
Canada
Sequential Gas Delivery
University of Calgary
Orthostatic Hypotension, Neurogenic Orthostatic Hypotension
12/26
05/27
CASA-POTS, NCT05924646: CAlgary SAlt for POTS

Recruiting
N/A
50
Canada
Sodium Chloride Capsules, Microcystalline Cellulose Capsules
University of Calgary
Postural Orthostatic Tachycardia Syndrome
06/28
12/28
NCT04271878: Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome

Recruiting
N/A
26
Canada
RespirAct™ system (Thornhill Research Inc., Toronto, Canada)
University of Calgary
Postural Tachycardia Syndrome, Orthostatic Intolerance
12/26
12/26
NCT05908760: CO2 Rebreathing in nOH: A Proof-of-Concept Pilot Study

Recruiting
N/A
28
Canada
CO2 ReHaler
University of Calgary
Neurogenic Orthostatic Hypotension, Autonomic Failure
12/27
12/28
NCT05914649: NC Testing in LC & POTS

Recruiting
N/A
100
Canada
IV normal saline (999 mL infusion), IV normal saline (50 mL infusion)
University of Calgary
Postural Orthostatic Tachycardia Syndrome, Post Acute Sequelae of SARS CoV 2 Infection
12/28
12/29
NCT06048731: Enlighten Study: the EV-ICD Post Approval Registry

Active, not recruiting
N/A
1000
Europe, Canada, US, RoW
Defibrillation using EV-ICD
Medtronic
Ventricular Arrhythmia, Tachycardia
05/30
10/37
Pop-Busui, Rodica
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

Recruiting
3
150
Canada, US
Sotagliflozin, INPEFA, Placebo
Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D
Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
12/28
05/29
TINSAL-T1DN, NCT02936843: Targeting Inflammation With Salsalate in Type 1 Diabetes Neuropathy

Completed
2/3
61
US
Salsalate, disalcid, PLACEBO
University of Michigan
Type 1 Diabetes, Peripheral Neuropathy
05/23
05/23
PERL-FENO, NCT04929379: A Pilot Study of Fenofibrate to Prevent Kidney Function Loss in Type 1 Diabetes

Active, not recruiting
2
40
US
Fenofibrate, Placebo
Alessandro Doria, University of Michigan, University of Minnesota
Diabetic Nephropathies
05/25
08/25
NCT05169060: Omega-3 Fatty Acid Lipidomics in Diabetes Peripheral Neuropathy

Recruiting
1/2
100
US
Fish Oil Concentrate, 1000 Mg Oral Capsule, Salsalate Oral Tablet
University of Iowa, University of Michigan
Diabetic Neuropathies
07/25
01/26
NCT05200819: Incidence and Predictors of Acute and Chronic Complications in Patients With Diabetes and Severe COVID-19

Completed
N/A
70
US
University of Michigan
Covid19, Diabetes Mellitus
02/23
02/23
NCT04591691: C-myc Biomarker Study for Diabetic Foot Ulcers

Completed
N/A
140
US
University of Michigan, Indiana University, Stanford University, University of Miami, University of Pittsburgh, University of California, San Francisco, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes, Diabetic Foot, Diabetic Foot Ulcer, Diabetic Wound
07/23
07/23
NCT05328986: Kidney Disease After COVID-19

Active, not recruiting
N/A
3000
US
Icahn School of Medicine at Mount Sinai, New Jersey Medical School, University of Michigan, Yale New Haven Health System Center for Healthcare Solutions, Johns Hopkins University
COVID-19, Acute Kidney Injury, Chronic Kidney Injury
01/25
01/25
NCT02748018: Multi-center Trial in Adult and Pediatric Patients With Type 1 Diabetes Using Hybrid Closed Loop System and Control at Home

Active, not recruiting
N/A
280
Europe, Canada, US, RoW
670G and 770G Insulin Pump, Subject's Current Diabetes Therapy
Medtronic Diabetes
Type 1 Diabetes
04/25
06/25
NCT06104969: DFC 004 Biomarkers for Active Diabetic Foot Ulcers

Recruiting
N/A
5000
US
University of Michigan, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetic Foot Ulcer, Diabetic Foot, Diabetes
06/28
06/28
Doria, Alessandro
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

Recruiting
3
150
Canada, US
Sotagliflozin, INPEFA, Placebo
Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D
Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
12/28
05/29
PERL-FENO, NCT04929379: A Pilot Study of Fenofibrate to Prevent Kidney Function Loss in Type 1 Diabetes

Active, not recruiting
2
40
US
Fenofibrate, Placebo
Alessandro Doria, University of Michigan, University of Minnesota
Diabetic Nephropathies
05/25
08/25
McGill, Janet
NCT05541484: Ketone Monitoring in T1D: Effect of SGLT2i During Usual Care and With Insulin Deficiency

Completed
4
21
US
SGLT2 inhibitor, Dapagliflozin 10mg (Farxiga), Biosense Breath Ketone Analyzer
Washington University School of Medicine, Juvenile Diabetes Research Foundation
Diabetes Mellitus, Type 1
12/23
12/23
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

Recruiting
3
150
Canada, US
Sotagliflozin, INPEFA, Placebo
Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D
Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
12/28
05/29
DIAGNODE-3, NCT05018585 / 2021-002731-32: A Phase III Study to Investigate if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 Diabetes

Recruiting
3
330
Europe, US, RoW
Recombinant human glutamic acid decarboxylase (rhGAD65) formulated in Alhydrogel®, Diamyd, Colecalciferol 2000 IU, Divisun 2000 IU, Placebo
Diamyd Medical AB
Type 1 Diabetes Mellitus
12/27
12/27
NCT04887935: Neoadjuvant SGLT2 Inhibition in High-Risk Localized Prostate Cancer

Recruiting
1
24
US
Dapagliflozin, Farxiga
Washington University School of Medicine, The Foundation for Barnes-Jewish Hospital
Prostate Cancer, Cancer of Prostate
08/26
08/26
COMP-SR, NCT02122666: Composition & Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome

Completed
N/A
27
US
muscle biopsy
Washington University School of Medicine
Metabolic Syndrome
02/24
02/24
Bourne, Kate
COM-COM-POTS, NCT04881318: Compression Garments in the Community With POTS

Recruiting
N/A
30
Canada
Waist-High Compression Tights, Abdominal Compression Garments, Abdominal shapewear, compression shorts, Medications that modulate heart rate and blood pressure
University of Calgary
Postural Orthostatic Tachycardia Syndrome
12/24
12/24
Dunlop, Amy
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

Recruiting
3
150
Canada, US
Sotagliflozin, INPEFA, Placebo
Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D
Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
12/28
05/29
CIRCUIT, NCT04902378: Closed-loop Insulin Delivery In Type 1 Diabetes Pregnancies

Active, not recruiting
N/A
94
Canada, RoW
Tandem t:slim X2 insulin pump with Control IQ technology
University of Calgary
Type 1 Diabetes Mellitus, Pregnancy Related, Glucose Metabolism Disorders, Metabolic Disease, Endocrine System Diseases
01/25
03/25

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