Toronto General Hospital
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 402 Trials 
1397 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
O'Neill, Brian P
HOVER, NCT02339974: Heterotopic Implantation of the Edwards-Sapien Transcatheter Aortic Valve in the Inferior VEna Cava for the Treatment of Severe Tricuspid Regurgitation

Active, not recruiting
3
6
US
Heterotopic Implantation Of the Edwards-Sapien XT Transcatheter Valve in the Inferior VEna Cava
Henry Ford Health System
Tricuspid Regurgitation
12/24
12/24
PACE-NODES, NCT05613023: A Trial of 5 Fraction Prostate SBRT Versus 5 Fraction Prostate and Pelvic Nodal SBRT

Recruiting
3
1128
Europe, RoW
SBRT, SABR
Institute of Cancer Research, United Kingdom, Prostate Cancer UK
Prostate Cancer
06/28
06/30
NCT04551651: AppReminders - A Pilot Feasibility Trial of a Memory Aid App for People With Acquired Brain Injury

Recruiting
N/A
50
Europe
ApplTree, Google Calendar
NHS Greater Glasgow and Clyde, University of Glasgow, Chief Scientist Office of the Scottish Government
Acquired Brain Injury
09/21
12/22
ECP EFS, NCT04477603: Impella ECP Early Feasibility Study

Active, not recruiting
N/A
100
US
Impella ECP
Abiomed Inc.
High-risk Percutaneous Coronary Intervention
10/25
10/25
ACCESS MANTA, NCT05936996: Prospective Clinical Registry Evaluating Contemporary MANTA Outcomes

Recruiting
N/A
250
Canada, US
MANTA Vascular Closure Device
Essential Medical, Inc., Essential Medical LLC a subsidiary of Teleflex, Incorporated
Femoral Arteriotomy Closure
01/25
03/25
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
01/25
04/30
NCT04482062: TRISCEND II Pivotal Trial

Active, not recruiting
N/A
1070
Europe, US
Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure
06/24
12/29
SHIELD, NCT06689839: Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR

Not yet recruiting
N/A
500
US
F2 Filter and Delivery System, Transcatheter Aortic Valve Replacement (TAVR)
EnCompass Technologies, Inc., Avania, Insight Medical Consulting
Aortic Stenosis Treated With TAVI, Aortic Diseases
07/26
10/26
VISTA-US, NCT05848284: Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation ( )

Recruiting
N/A
30
US
VDyne Transcatheter Tricuspid Valve Replacement System, VDyne System, VDyne Tricuspid System, VDyne Valve System, VDyne Valve
VDyne, Inc.
Tricuspid Regurgitation, Tricuspid Valve Disease, Tricuspid Valvular Disorders
11/25
11/30
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
CORRAL-AF, NCT04684212: Can the Lambre Device Occlude IRRegular And Large Appendages in Patients With Non-Valvular AF

Not yet recruiting
N/A
2931
US
LAmbre PlusTM Left Atrial Appendage Closure System, LAmbre device, Market approved oral anticoagulation (OAC), such as warfarin (Coumadin), dabigatran (Pradaxa), rivaroxaban (Xarelto), apixiban (Eliquis), edoxaban (Savaysa), or betrixaban (Bevyxxa), OAC
Brian O'Neill MD, Lifetech Scientific (Shenzhen) Co., Ltd.
Atrial Fibrillation, Left Atrial Appendage Thrombosis, CVA
12/29
12/34
Dzavik, Vladimir
SEMPATICO, NCT04615871: Semaglutide to Reduce Myocardial Injury in PATIents With COVID-19

Recruiting
2
400
Europe, Canada, RoW
semaglutide, Ozempic
Vladimír Džavík, Unity Health Toronto, Canadian Institutes of Health Research (CIHR), University of Toronto
Covid19, Myocardial Injury
03/22
03/22
COSIRA-II, NCT05102019: Efficacy of the COronary SInus Reducer in Patients with Refractory Angina II

Recruiting
N/A
380
Canada, US
Arm 1: treatment with Neovasc Reducer, Arm 2 (control): Implantation procedure with no device implanted, Arm 3 (unblinded, non-randomized): Single arm registry
Neovasc Inc., Shockwave Medical, Inc.
Refractory Angina
06/25
12/28
Crandall, Jill
DPPOS, NCT00038727: Diabetes Prevention Program Outcomes Study

Active, not recruiting
3
2779
US
DPPOS Group Lifestyle, Metformin, Glucophage, DPPOS Boost Lifestyle, Intensive Lifestyle Group Session, Intensive lifestyle session (ILS)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Aging (NIA), National Institute on Minority Health and Health Disparities (NIMHD), National Heart, Lung, and Blood Institute (NHLBI), National Cancer Institute (NCI), National Eye Institute (NEI), National Center for Research Resources (NCRR), Office of Research on Women's Health (ORWH), Centers for Disease Control and Prevention, American Diabetes Association, Indian Health Service, General Clinical Research Program, US Department of Veterans Affairs
Diabetes Mellitus, Cancer, CVD
10/24
01/25
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons with Type 1 Diabetes and Diabetic Kidney Disease

Recruiting
3
150
Canada, US
Sotagliflozin, INPEFA, Placebo
Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D
Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure
12/28
05/29
NCT03809299: 2-A-Day Study: Twice a Day Meals Study.

Completed
N/A
60
US
Ad libitum meal timing, Twice a day meals
Albert Einstein College of Medicine, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
PreDiabetes
06/22
06/22
Knox, Jennifer
EMERALD-2, NCT03847428 / 2018-004105-85: Assess Efficacy and Safety of Durvalumab Alone or Combined With Bevacizumab in High Risk of Recurrence HCC Patients After Curative Treatment

Hourglass Jan 2022 - Dec 2023 : Acceptance of regulatory submission in China for HCC based on EMERALD-2 trial
Jan 2023 - Jun 2023: Data from EMERALD-2 trial for HCC
Active, not recruiting
3
908
Europe, Canada, Japan, US, RoW
Durvalumab, IMFINZI, Bevacizumab, AVASTIN, Placebo
AstraZeneca, AstraZeneca AB
Hepatocellular Carcinoma
05/26
05/27
PASS-01, NCT04469556: Pancreatic Adenocarcinoma Signature Stratification for Treatment

Active, not recruiting
2
150
Canada, US
Folfirinox, Folinic Acid/Leucovorin, 5-Fluouracil, Irinotecan, Oxaliplatin, Gemcitabine/nab-paclitaxel
University Health Network, Toronto, Johns Hopkins University, Cold Spring Harbor Laboratory, Ontario Institute for Cancer Research, Dana-Farber Cancer Institute, Memorial Sloan Kettering Cancer Center, Stand Up To Cancer
Pancreatic Cancer Metastatic, Pancreatic Ductal Adenocarcinoma, Advanced Pancreatic Cancer
01/25
09/26
CaboTx, NCT04204850: Cabozantinib to Treat Recurrent Liver Cancer Post Transplant

Recruiting
2
20
Canada
Cabozantinib, CABOMETYX
University Health Network, Toronto, Ipsen
Hepatocellular Carcinoma, Recurrent Cancer, Liver Transplant
08/25
12/25
NCT02151084: A Study of Different Dosing Schedules of Selumetinib With Cisplatin/Gemcitabine (CIS/GEM) Versus CIS/GEM Alone in Biliary Cancer

Active, not recruiting
2
57
Canada
Selumetinib, AZD6244, Cisplatin, Platinol, Gemcitabine, Gemzar
University Health Network, Toronto
Biliary Tract Carcinoma, Gallbladder Carcinoma
12/24
12/25
PEMRAD, NCT03316872: Study of Pembrolizumab and Radiotherapy in Liver Cancer

Active, not recruiting
2
19
Canada
Pembrolizumab, KEYTRUDA, Stereotactic Body Radiotherapy (SBRT)
University Health Network, Toronto
Hepatocellular Carcinoma
12/24
12/24
NEOTOMA, NCT05440864: Durvalumab and Tremelimumab in Resectable HCC

Recruiting
2
28
Europe, Canada
Tremelimumab, Durvalumab
University Health Network, Toronto, Clinica Universidad de Navarra, Universidad de Navarra, University of Milan
Hepatocellular Carcinoma
11/25
11/26
ADVANCE HCC, NCT05137899: Neoadjuvant Combination of Atezolizumab/Bevacizumab Versus Neoadjuvant Radiation Therapy

Recruiting
2
70
Canada
Neoadjuvant
Ontario Clinical Oncology Group (OCOG), Hoffmann-La Roche
Hepatocellular Carcinoma, Portal Vein Tumour Thrombosis
06/26
06/26
SLC-0111-17-01, NCT03450018: A Study of SLC-0111 and Gemcitabine for Metastatic Pancreatic Ductal Cancer in Subjects Positive for CAIX

Terminated
1/2
6
Canada
SLC-0111, WBI-5111, Gemcitabine Injection, Gemcitabine
British Columbia Cancer Agency, Canadian Cancer Society (CCS), SignalChem Lifesciences Corporation
Metastatic Pancreatic Ductal Adenocarcinoma
05/24
05/24
COMPASS, NCT02750657: Study of Changes and Characteristics of Genes in Patients With Pancreatic Cancer for Better Treatment Selection

Active, not recruiting
N/A
332
Canada
Molecular Profiling
University Health Network, Toronto
Carcinoma, Pancreatic Ductal
12/24
12/24
NeoPancOne, NCT04472910: GATA6 Expression as a Predictor of Response to Peri-Operative Chemotherapy in Resectable Pancreatic Adenocarcinoma

Active, not recruiting
N/A
84
Canada
Modified Folforinox (mFFX), Folfirinox or other approach
University Health Network, Toronto, Pancreatic Cancer Canada
Resectable Pancreatic Cancer
12/25
12/25
Patel, Keyur
NAVIGATE, NCT04365868 / 2019-001983-31: Study Evaluating the Efficacy and Safety of Belapectin for the Prevention of Esophageal Varices in NASH Cirrhosis

Active, not recruiting
2b
357
Europe, Canada, US, RoW
belapectin, GR-MD-02, galactoarabino rhamnogalacturonate, Placebo
Galectin Therapeutics Inc., Galectin Therapeutics Inc
Prevention of Esophageal Varices, NASH - Nonalcoholic Steatohepatitis, Cirrhosis
12/24
12/24
HORIZON, NCT05583344 / 2022-002538-14: Phase 2b Study of GSK4532990 in Adults With NASH

Active, not recruiting
2
271
Europe, Canada, Japan, US, RoW
GSK4532990, Placebo
GlaxoSmithKline, GlaxoSmithKline Research & Development Limited
Nonalcoholic Fatty Liver Disease, Non-alcoholic Fatty Liver Disease
12/25
03/26
NCT05687656: Sterilised, Porcine Placental Tissue in the Treatment of Chronic Diabetic Foot Ulcers

Completed
N/A
30
US
InnovaMatrix AC porcine placental ECM therapy
ConvaTec Inc.
Diabetic Foot Ulcer
01/24
01/24
NCT05291169: Omeza Combination Therapy With Standard of Care to Standard of Care Alone for Chronic Venous Leg Ulcers

Completed
N/A
54
US
Omeza® OCM™, Omeza® Complete Matrix, Multimodal Wound Matrix
Omeza, LLC
Venous Leg Ulcer
11/23
03/24
IPCOTT, NCT05659394: Intermittent Pneumatic Compression of the Thigh

Completed
N/A
136
US
Standard Wound Care Alone, Stand Wound Care plus IPC
Huntleigh Healthcare Ltd, SerenaGroup, Inc.
Venous Leg Ulcer
03/24
03/24
NCT06606210: INNOVEN: Efficacy of Porcine Placental Extracellular Matrix Plus Standard of Care (SOC) Versus SOC Alone

Recruiting
N/A
120
US
InnovaMatrix® AC, Porcine Derived Extracellular Matrix
ConvaTec Inc.
Wound Heal, Venous Leg Ulcer
07/25
04/26
NCT05923749: A RCT Evaluating the Clinical Benefit of a Silver Dressing in the Treatment of Venous Leg Ulcers

Recruiting
N/A
178
Europe, US
Biatain Ag, Cutimed Siltec Sorbact
Coloplast A/S
Wound Heal
10/25
10/25
Cheung, Angela M
NCT01896011: Effect of Teriparatide on Fracture Healing in Patients With Incomplete Atypical Femur Fractures

Completed
3
34
Canada
Teriparatide 20 mcg, Brand name Forteo, Placebo
University Health Network, Toronto, The Physicians' Services Incorporated Foundation, Eli Lilly and Company
Non Displaced Atypical Femoral Fractures
12/21
12/22
PRECIOSA, NCT03451292 / 2016-001789-28: Effects of Long-Term Administration of Human Albumin in Subjects With Decompensated Cirrhosis and Ascites

Completed
3
410
Europe, Canada, US, RoW
Albutein 20% Injectable Solution, Standard medical treatment
Grifols Therapeutics LLC, Instituto Grifols, S.A.
Decompensated Cirrhosis and Ascites
05/24
05/24
NCT04950127 / 2021-000007-21: Global Linerixibat Itch Study of Efficacy and Safety in Primary Biliary Cholangitis (PBC) (GLISTEN)

Active, not recruiting
3
238
Europe, Canada, Japan, US, RoW
Linerixibat, Placebo
GlaxoSmithKline
Pruritus
10/24
01/25
ESSOR, NCT05999435: Study of LAU-7b for the Treatment of Long COVID in Adults

Active, not recruiting
2/3
272
Canada
LAU-7b for 3 cycles, fenretinide, LAU-7b for 1 cycle, then placebo, Placebo for 3 cycles, sugar pill
Laurent Pharmaceuticals Inc.
Long COVID
08/24
10/24
RECLAIM - HBOT, NCT06452095: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hyperbaric Oxygen Therapy for the Treatment of Post COVID Condition

Not yet recruiting
2/3
120
NA
Hyperbaric Oxygen therapy
University Health Network, Toronto
Long COVID, Post COVID Condition, Post Acute Sequelae of COVID-19
12/28
12/28
RECLAIM, NCT05513560: Recovering from COVID-19 Lingering Symptoms Adaptive Integrative Medicine

Suspended
2/3
460
Canada
Ibudilast, MN-166, Pentoxifylline, Placebo
University Health Network, Toronto
Long COVID, Post COVID Condition, Post Acute Sequelae of COVID-19
05/26
12/26
VISTAS, NCT04663308 / 2020-003027-41: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

Recruiting
2
200
Europe, Canada, US, RoW
Volixibat, SHP626, Placebo
Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc.
Primary Sclerosing Cholangitis
09/25
12/25
Hi-OXSR, NCT06379620: Pilot Open Label Use of the for the Treatment of Post COVID-19 Cognitive Dysfunction

Completed
1
37
Canada
Hi-OxSR Sequential Rebreathing mask (oxygen concentrator)
University Health Network, Toronto
Post COVID-19 Condition
03/24
03/24
NCT05231668: Single Ascending Dose Study of SAR439459 in Adults With Osteogenesis Imperfecta (OI)

Terminated
1
16
Europe, Canada, US, RoW
SAR439459, Placebo
Sanofi
Osteogenesis Imperfecta
11/24
11/24
NCT01155245: Teriparatide (PTH) and Bone Strength in Postmenopausal Women

Active, not recruiting
N/A
60
Canada
Forteo
University Health Network, Toronto, Eli Lilly and Company
Osteoporosis
01/24
01/25
NCT01747304: Evaluation of IVA (SE Femur Scans) to Identify Incomplete AFFs

Recruiting
N/A
500
Canada
DXA Se femur scans (previously called IVA femur), SF Femur scans
University Health Network, Toronto
Atypical Femur Fracture
12/24
12/25
NCT01155232: Effects of Teriparatide (PTH) on Bone in Men and Women With Osteoporosis

Recruiting
N/A
100
Canada
Teriparatide, Teriparatide is a section of the parathyroid hormone (PTH) given by injection., The drug is marketed by Eli Lilly under the name of Forteo
University Health Network, Toronto
Osteoporosis
01/25
01/26
NCT01747291: Atypical Fracture Cohort Study

Recruiting
N/A
300
Canada
University Health Network, Toronto
Atypical Femur Fracture, Atypical Subtrochanteric Fracture, Osteoporosis With AFf
12/25
12/26
NCT04110795: Personalizing Osteoporosis Care: Clinical & Genetic Risk Factors for AFFs

Active, not recruiting
N/A
1200
Canada
No Intervention
University Health Network, Toronto, Canadian Institutes of Health Research (CIHR)
Atypical Femur Fracture
12/25
12/27
NCT05541432: Finding the Optimal Resistance Training Intensity For Your Bones

Recruiting
N/A
324
Canada
Supervised strength training (group 1), Supervised strength training (group 2), Home exercise
University of Waterloo, Canadian Institutes of Health Research (CIHR), University of Saskatchewan, University Health Network, Toronto
Osteoporosis, Osteopenia
09/26
09/26
CaNAL, NCT03569826: Canadian Network for Autoimmune Liver Disease

Recruiting
N/A
2500
Canada
Observational; no intervention
University Health Network, Toronto
Primary Bilary Cirrhosis (PBC), Autoimmune Hepatitis, Overlap Syndrome
12/28
12/28
Allard, Johane
NCT02970877: Stool Transplantation for Treatment of Insulin Resistance in Morbidly Obese Patients

Active, not recruiting
2
48
Canada
Fecal filtrate from 150 g stool from healthy lean donors, Intestinal microbiota from healthy lean donors, Fecal filtrate from 150 g of the recipient's own stool, Autologous intestinal microbiota
Johane Allard, Canadian Institutes of Health Research (CIHR), MOUNT SINAI HOSPITAL, University of Toronto
Obesity, Morbid, Insulin Resistance
06/22
11/22
NCT01856465: Intestinal Microbiota and NAFLD Pre and Post Bariatric Surgery

Active, not recruiting
N/A
120
Canada
Johane Allard, Canadian Institutes of Health Research (CIHR)
Morbid Obesity, Non-alcoholic Fatty Liver Disease
06/22
08/23
NCT03723486: Bariatric Surgery: Microbiome & Diabetes

Active, not recruiting
N/A
120
Canada
University Health Network, Toronto, Canadian Institutes of Health Research (CIHR)
Obesity
06/22
12/23
NCT04067245: Use of Tetrasodium EDTA Catheter Lock Solution for Patients on HTPN

Recruiting
N/A
20
Canada
Tetrasodium EDTA catheter lock solution
University Health Network, Toronto
Catheter Complications
12/24
03/25
NCT02298439: Fatty Liver Patient Registry

Recruiting
N/A
100
Canada
University Health Network, Toronto
Non-Alcoholic Fatty Liver Disease
06/26
06/26
HTPN, NCT02299466: Registry for Patients Receiving Intravenous Nutrition at Home

Recruiting
N/A
1000
Canada
University Health Network, Toronto, Canadian Nutrition Society, Baxter Healthcare Corporation, Ontario Medical Supply
Parenteral Nutrition, Home
12/29
12/29
Lewis, Gary F
PALISADE, NCT05089084 / 2021-003680-10: Study of ARO-APOC3 (Plozasiran) in Adults With Familial Chylomicronemia Syndrome (FCS)

Active, not recruiting
3
75
Europe, Canada, Japan, US, RoW
Plozasiran, ARO-APOC3, Placebo
Arrowhead Pharmaceuticals
Familial Chylomicronemia
04/24
04/26
TED+GLC plasma, NCT03860688: Effects of Oral Glucose and Teduglutide on Plasma Lipoproteins

Recruiting
2/3
15
Canada
TED + glucose
University Health Network, Toronto
Hyperlipidemias
12/21
05/22
ECOG-ACRIN EA3202, NCT05063552: Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers

Recruiting
2/3
430
US
Atezolizumab, MPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG 7446, RG-7446, RG7446, RO 5541267, RO-5541267, RO5541267, Tecentriq, Bevacizumab, ABP 215, ABP-215, ABP215, Alymsys, Anti-VEGF, Anti-VEGF Humanized Monoclonal Antibody, Anti-VEGF Monoclonal Antibody SIBP04, Anti-VEGF rhuMAb, Avastin, Avzivi, Aybintio, BAT 1706, BAT-1706, BAT1706, BAT1706 Biosimilar, Bevacizumab awwb, Bevacizumab Biosimilar ABP 215, Bevacizumab Biosimilar BAT1706, Bevacizumab Biosimilar BEVZ92, Bevacizumab Biosimilar BI 695502, Bevacizumab Biosimilar CBT 124, Bevacizumab Biosimilar CT-P16, Bevacizumab Biosimilar FKB238, Bevacizumab Biosimilar GB-222, Bevacizumab Biosimilar HD204, Bevacizumab Biosimilar HLX04, Bevacizumab Biosimilar IBI305, Bevacizumab Biosimilar LY01008, Bevacizumab Biosimilar MB02, Bevacizumab Biosimilar MIL60, Bevacizumab Biosimilar Mvasi, Bevacizumab Biosimilar MYL-1402O, Bevacizumab Biosimilar QL 1101, Bevacizumab Biosimilar QL1101, Bevacizumab Biosimilar RPH-001, Bevacizumab Biosimilar SCT501, Bevacizumab Biosimilar Zirabev, Bevacizumab-adcd, Bevacizumab-awwb, Bevacizumab-aybi, Bevacizumab-bvzr, Bevacizumab-equi, Bevacizumab-maly, Bevacizumab-onbe, Bevacizumab-tnjn, BP102, BP102 Biosimilar, CT P16, CT-P16, CTP16, Equidacent, FKB 238, FKB-238, FKB238, HD204, Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer, MB 02, MB-02, MB02, Mvasi, MYL-1402O, Onbevzi, Oyavas, PF 06439535, PF-06439535, PF06439535, QL1101, Recombinant Humanized Anti-VEGF Monoclonal Antibody, rhuMab-VEGF, SCT501, SIBP 04, SIBP-04, SIBP04, Vegzelma, Zirabev, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Cetuximab, C 225, C-225, C225, Cetuximab Biosimilar CDP-1, Cetuximab Biosimilar CMAB009, Cetuximab Biosimilar KL 140, Chimeric Anti-EGFR Monoclonal Antibody, Chimeric MoAb C225, Chimeric Monoclonal Antibody C225, Erbitux, IMC-C225, Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Docetaxel, Docecad, RP 56976, RP-56976, RP56976, Taxotere, Taxotere Injection Concentrate, Echocardiography, EC, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT
National Cancer Institute (NCI)
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma, Metastatic Laryngeal Squamous Cell Carcinoma, Metastatic Lip and Oral Cavity Carcinoma, Metastatic Nasal Cavity Squamous Cell Carcinoma, Metastatic Nasopharyngeal Squamous Cell Carcinoma, Metastatic Pharyngeal Squamous Cell Carcinoma, Metastatic Sinonasal Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma, Recurrent Lip and Oral Cavity Squamous Cell Carcinoma, Recurrent Nasopharyngeal Squamous Cell Carcinoma, Recurrent Pharyngeal Squamous Cell Carcinoma, Recurrent Sinonasal Squamous Cell Carcinoma, Stage IV Hypopharyngeal Carcinoma AJCC v8, Stage IV Laryngeal Cancer AJCC v8, Stage IV Lip and Oral Cavity Cancer AJCC v8, Stage IV Nasopharyngeal Carcinoma AJCC v8, Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8, Stage IV Sinonasal Cancer AJCC v8
12/27
12/27
NRG-HN009, NCT05050162: Comparing High-Dose Cisplatin Every Three Weeks to Low-Dose Cisplatin Weekly When Combined With Radiation for Patients With Advanced Head and Neck Cancer

Recruiting
2/3
464
Europe, Canada, US, RoW
Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Radiation Therapy, Cancer Radiotherapy, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation
NRG Oncology, National Cancer Institute (NCI)
Advanced Head and Neck Squamous Cell Carcinoma, Advanced Hypopharyngeal Squamous Cell Carcinoma, Advanced Laryngeal Squamous Cell Carcinoma, Advanced Oropharyngeal Squamous Cell Carcinoma, Squamous Cell Carcinoma of Unknown Primary
02/31
02/36
VOICE, NCT04648020 / 2021-000999-11: Clonidine HCl MBT vs. Placebo to Prevent Chemoradiotherapy-Induced Severe Oral Mucositis in Oropharyngeal Cancer.

Terminated
2b
190
Europe, US
Clonidine HCl Mucoadhesive Buccal Tablet, Validive®, Placebo Mucoadhesive Buccal Tablet
Monopar Therapeutics, Monopar Therapeutics Inc.
Chemoradiotherapy-Induced Severe Oral Mucositis
05/23
05/23
NCT05103761: Effect of Diet Induced Ketosis on LDL Turnover Rates

Recruiting
N/A
24
Canada
Study diet, Nutritional intervention, Low glycemic index treatment diet, Control
University Health Network, Toronto
Ketosis, Metabolic
12/22
06/23
NCT03552965: Margin-Based Vs. Robust Photon Radiotherapy Planning in IMRT of HN-SQCC

Active, not recruiting
N/A
50
US
Robust Radiotherapy planning, Margin-Based Radiotherapy planning
University of Arkansas
Squamous Cell Carcinoma of the Head and Neck
07/25
07/26
NCT05440760: Using Virtual Reality Technology to Improve Patient Experience and Quality of Care During Brachytherapy

Recruiting
N/A
20
US
The Oculus Quest 2 Virtual Reality Headset
University of Arkansas
Endocervical Cancer
07/25
12/26
NCT05323253: A Clinical Study to Assess the Efficacy and Safety of Alpha DaRT224 for the Treatment of Patients With Recurrent Cutaneous Squamous Cell Carcinoma

Recruiting
N/A
86
Canada, US, RoW
DaRT seeds, DaRT
Alpha Tau Medical LTD.
Recurrent Squamous Cell Carcinoma
12/24
12/25
Brochard, Laurent
OWED, NCT02539732: Prediction of Outcome of Weaning From Mechanical Ventilation Using the Electrical Activity of the Diaphragm

Recruiting
N/A
110
Europe, Canada
Unity Health Toronto
Respiratory Insufficiency
12/21
12/21
NCT03902639: Examining the Effects of Nasal High Flow Oxygen Therapy Compared to Non-invasive Ventilation in Health Volunteers

Recruiting
N/A
10
Canada
Unity Health Toronto
Healthy Volunteers
12/24
12/24
RECRUIT, NCT04460859: RecruitmEnt Assessed by eleCtRical Impedance Tomography

Recruiting
N/A
171
Europe, Canada, RoW
Specific lung recruitment maneuvers
Unity Health Toronto
Acute Respiratory Distress Syndrome (ARDS)
12/21
06/22
HiFOLD, NCT03033251: High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease

Recruiting
N/A
30
Canada
Non Invasive Ventilation, Standard of Care, High Flow Oxygen Cannula 50, HFNO 50, High Flow Oxygen Cannula 30, HFNO 30
Unity Health Toronto
Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
07/24
07/24
BEARDS, NCT03447288: Incidence of Dyssynchronies in Early ARDS

Recruiting
N/A
300
Europe, Canada, RoW
Unity Health Toronto
ARDS, Acute Hypoxemic Respiratory Failure
08/22
08/22
ULTIMATE, NCT04832789: Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO

Not yet recruiting
N/A
72
Canada, US
Venovenous ECMO
University of Toronto, University Health Network, Toronto
ARDS
06/23
12/23
ACCESSIT, NCT05207046: The Study

Recruiting
N/A
30
Canada
Mechanical Ventilation
Unity Health Toronto
Respiratory Support
06/23
06/23
PROMIZING, NCT02447692: Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The Study

Completed
N/A
575
Europe, Canada, RoW
PSV ventilation strategy, PAV+ ventilation strategy
Lawson Health Research Institute, Canadian Institutes of Health Research (CIHR), Medtronic, Canadian Critical Care Trials Group
Critically Ill, Acute Respiratory Failure
07/24
07/24
VICTORY, NCT06196125: Ventilation dIstribution and effeCt of posTural Lateralization On Traumatic Lung injuRY: a Physiological Study

Active, not recruiting
N/A
24
Canada
Four body positions
Unity Health Toronto
Trauma Chest, Mechanical Ventilation
11/24
11/24
RENOVATE, NCT03643939: High-Flow Nasal Oxygen Cannula Compared to Non-Invasive Ventilation in Adult Patients With AcuTE Respiratory Failure

Completed
N/A
1801
RoW
High Flow Nasal Catheter, Optiflow, Airvo, trans-nasal insufflation, Nasal High Flow, High Flow Nasal Cannula, nasal cannula with high-flow oxygen, Noninvasive ventilation, BiPAP, Non-invasive ventilation, Noninvasive positive pressure ventilation
Hospital do Coracao, Ministry of Health, Brazil, Berry Consultants
Respiratory Insufficiency, Respiratory Failure
11/23
02/24
HONOUR, NCT05078034: HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT

Recruiting
N/A
200
Canada
Helmet Non-Invasive Ventilation (HNIV), HNIV, High Flow Nasal Oxygen, HFNO
Sunnybrook Health Sciences Centre
Acute Hypoxemic Respiratory Failure
02/25
02/25
NCT05883163: STIMIT Activator 1 IDE Pivotal Study

Recruiting
N/A
40
US
Stimit Activator 1
Stimit AG
Diaphragm Issues
12/24
03/25
AiCLOSE, NCT05196074: Airway Closure During Extracorporeal Membrane Oxygenation: The Study

Recruiting
N/A
299
Canada
Acute hypoxemic respiratory failure patients on VV-ECMO
Lorenzo delSorbo, Unity Health Toronto
Acute Hypoxemic Respiratory Failure
04/25
04/26
POET, NCT05825534: Pressure Opening With Electrical Impedance Tomography

Recruiting
N/A
30
Europe
EIT monitoring
Centre Hospitalier Universitaire, Amiens, Unity Health Toronto
Acute Respiratory Distress Syndrome, Acute Lung Injury
05/24
05/24
SEVERE, NCT06293976: Susceptibility for Entrainment: Role of Ventilator Settings on the Occurrence of Reverse Triggering and Its Physiological Consequences - the SEVeRe Study

Recruiting
N/A
30
Canada
Changes in the ventilator respiratory rate and tidal volume
Unity Health Toronto
Respiration, Artificial, Reverse Triggering
03/26
03/26
CAVIARDS, NCT03963622: Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)

Recruiting
N/A
740
Europe, Canada, US, RoW
Respiratory Mechanics, Standard Ventilation Strategy
Unity Health Toronto, Canadian Institutes of Health Research (CIHR), University of Toronto, Applied Health Research Centre
ARDS
11/25
03/26
INTRINSIC, NCT06445049: Intrinsic Respiratory Rate Assessment During Mechanical Ventilation to Accelerate Spontaneous Breathing and Extubation

Not yet recruiting
N/A
70
NA
brief test
Unity Health Toronto
Reverse Triggering, Patient Ventilator Dyssynchrony
06/27
06/27
PUMA, NCT06494085: Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation

Not yet recruiting
N/A
20
NA
Measuring Respiratory Mechanics, Randomized Pressure Support
Unity Health Toronto
Acute Hypoxemic Respiratory Failure
02/25
02/25
CNAP in ARDS, NCT03425318: Continuous Negative Abdominal Pressure in ARDS

Recruiting
N/A
40
Canada
CNAP
The Hospital for Sick Children, Unity Health Toronto
Acute Respiratory Distress Syndrome
12/24
12/24
SIMPLIFY, NCT05011877: The Simplify Project

Not yet recruiting
N/A
50
NA
High-flow nasal cannula therapy
Unity Health Toronto
Acute Hypercapnic Respiratory Failure
07/24
07/24
Salit, Irving E
NCT03947775: HPV-SAVE_Merck_Sub-Study for Preventing Recurrence of HSIL

Not yet recruiting
2
228
Canada
9-valent HPV vaccination, Gardasil-9
University Health Network, Toronto, Merck Sharp & Dohme LLC
Anal Intraepithelial Neoplasia, Anal Cancer, Human Papilloma Virus
03/26
05/26
Katz, Joel
NCT03986060 / 2019-000996-17: Shouldice Hospital Outcome Study

Recruiting
N/A
3000
Canada
York University
Inguinal Hernia
05/23
05/24
Waddell, Thomas
SORT, NCT05183932: Surgery Versus Stereotactic Body Radiation Therapy for Stage I Non-Small Cell Lung Cancer

Recruiting
N/A
440
Canada, US
Washington University School of Medicine, National Cancer Institute (NCI)
Non Small Cell Lung Cancer, Non-small Cell Lung Cancer
01/27
01/27
Djaiani, George N
CODEX, NCT04289142: Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients

Recruiting
4
2400
Canada
Dexmedetomidine Hydrochloride Group, Dexmedetomidine Hydrochloride
Sunnybrook Health Sciences Centre, London Health Sciences Centre, University Health Network, Toronto, McMaster University
Delirium, Cognitive Dysfunction, Cognition Disorder, Neurocognitive Disorders, Mental Disorders, Confusion, Neurobehavioral Manifestations, Neurologic Manifestations, Nervous System Diseases, Signs and Symptoms, Dexmedetomidine, Hypnotics and Sedatives, Central Nervous System Depressants, Physiological Effects of Drugs, Analgesics, Non-Narcotic, Analgesics, Molecular Mechanisms of Pharmacological Action
03/26
03/26
NCT01903421: Inhalational Anesthesia and Precipitation of Dementia: is There a Link?

Active, not recruiting
N/A
500
Europe, Canada
Spinal anesthesia group: bupivacaine 10-15mg, General anesthesia group: induction propofol 1.5-2mg/kg and fentanyl 1-3g/kg, maintained with isoflurane or sevoflurane, Blood test, Lumbar spinal tap, Montreal Cognitive Assessment (MOCA) and MMSE
University Health Network, Toronto
Alzheimer's Disease, Dementia
11/19
07/23
NCT03861026: Cerebral Oximetry to Reduce Organ Dysfunction After Non-cardiac Surgery

Completed
N/A
101
Canada
Bilateral NIRS (Masimo, O3TM Regional Oximetry)
University Health Network, Toronto
Cerebral Desaturation, Surgery
01/23
06/23
ENGAGES, NCT02692300: EEG Guidance of Anesthesia (-CANADA)

Completed
N/A
1225
Canada
EEG-Guided Group
University of Manitoba, Queen's University, University of Washington, University of Toronto, Université de Montréal
Post-operative Delirium
02/22
02/23
Kennedy, Sidney H
CAN-BIND-17, NCT05017311: Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)

Recruiting
4
400
Canada
Escitalopram, Cipralex, Brexpiprazole, Rexulti
Nova Scotia Health Authority, Unity Health Toronto, Centre for Addiction and Mental Health, McMaster University, Queen's University, University of Ottawa, University of British Columbia, University of Calgary, McGill University, Dalhousie University, University of Michigan, Simon Fraser University
Major Depressive Disorder
12/28
04/29
NCT04162522: Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Study

Completed
3
1
Canada
Escitalopram, Cipralex, Brexpiprazole, Rexulti
University Health Network, Toronto, Unity Health Toronto, Baycrest, Centre for Addiction and Mental Health, McMaster University, Queen's University, University of Ottawa, University of British Columbia, University of Calgary, McGill University, Dalhousie University, University of Michigan, Simon Fraser University
Major Depressive Disorder
12/22
12/22
NCT05711940: Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD

Recruiting
3
568
Europe, Canada, US, RoW
Psilocybin, COMP360
COMPASS Pathways
Treatment Resistant Depression
03/25
05/25
NCT03674671: Ketamine Versus Electroconvulsive Therapy in Depression

Suspended
3
240
Canada
Intravenous Ketamine, Ketalar, Electroconvulsive Therapy, ECT
University of Ottawa, McGill University, Queen's University, University Health Network, Toronto, Ontario Shores Centre for Mental Health Sciences
Depressive Disorder, Major, Bipolar Depression
12/25
12/25
ENLIGHTEN, NCT05113771: A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment-Resistant Depression

Completed
2
197
Canada, US
Liafensine, Placebo
Denovo Biopharma LLC
Treatment Resistant Depression
02/24
03/24
NCT04495543: Mitigating Suicide Risk With Single Session 'Brief Skills for Safer Living'

Completed
N/A
77
Canada
Brief Skills for Safer Living, Brief-SfSL
Unity Health Toronto
Suicidal Ideation, Suicide, Mental Health Issue, Depression
03/23
03/23
ENABLE, NCT06408012: An Innovative Master Platform for Clinical Trials in Mood Disorders

Recruiting
N/A
900
Canada
St. Joseph's Healthcare Hamilton, Unity Health Toronto, Centre for Addiction and Mental Health, Queen's University, University of Ottawa, University of British Columbia, University of Calgary, McGill University, Nova Scotia Health Authority, University of Michigan, Simon Fraser University, University Health Network, Toronto
Mood Disorders, Depressive Disorder, Bipolar and Related Disorders
03/26
03/26
Yau, Terrence M
REVERSE-IT, NCT04286438 / 2019-004457-92: Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

Completed
3
226
Europe, Canada, US, RoW
Bentracimab (PB2452) Infusion
SFJ Pharmaceuticals, Inc.
Hemorrhage, Urgent Surgery, Invasive Procedure
09/24
09/24
Puskas, John D
PACES, NCT04045665 / 2021-005022-18: Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

Recruiting
3
3200
Europe, Canada, US
Antiplatelet-only strategy, Oral Anticoagulant plus background antiplatelet therapy
Icahn School of Medicine at Mount Sinai, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University Medical Center
Atrial Fibrillation, Stroke, Bleeding
06/25
06/25
 

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