| Francois, Bruno |
ASUCOV, NCT05639192: Asunercept for the Treatment of Patients With Moderate to Severe COVID-19 Disease |
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| Terminated | 3 | 34 | Europe, RoW | Asunercept, Placebo | Apogenix GmbH | COVID-19 | 08/23 | 08/23 | | |
| Recruiting | 3 | 564 | Europe | Suvratoxumab, AR-320, MEDI4893, Placebo | Aridis Pharmaceuticals, Inc. | Ventilator Associated Pneumonia, Staphylococcus Aureus | 10/23 | 06/24 | | |
HAP-DEX, NCT06269900: Dexamethasone for Treating Severe Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype |
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| Recruiting | 3 | 450 | Europe | Dexamethasone, Placebo | Nantes University Hospital | Hospital Acquired Pneumonia | 03/26 | 08/26 | | |
PLATINIUM, NCT06774235: Prevention of Secondary Infections by Interferon Gamma in ICU-acquired Sustained Immune-suppression |
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| Not yet recruiting | 3 | 326 | Europe | Interferon Gamma 1-b, Placebo | University Hospital, Limoges | Sustained Immunosuppression | 09/28 | 09/28 | | |
TREAT-HAP, NCT05914584: "Baricitinib for Treating Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype. |
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| Not yet recruiting | 3 | 450 | Europe | Baricitinib 4 MG | Nantes University Hospital | Hospital-acquired Pneumonia | 08/25 | 12/25 | | |
NCT05962606: Safety and Efficacy of AON-D21 in Severe Community-Acquired Pneumonia. |
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| Recruiting | 2 | 150 | Europe | AON-D21, Placebo | Aptarion Biotech AG | Community-acquired Pneumonia | 05/26 | 06/26 | | |
| PIGUET, Christophe |
| Recruiting | 3 | 800 | Europe, RoW | Vincristine, L01CA02, Carboplatin, LO1XA02, Etoposide, L01CB01, Vindesine, L01CA03, Dacarbazine, L01AX04, Ifosfamide, Doxorubicin, L01DB01, Busulfan, L01AB01, Melphalan, L01AA03, Thiotepa, L01AC01, Radiotherapy, Dinutuximab Beta, L01XC16, Cisplatin, L01XA01, Temozolomide 100 MG, Irinotecan, Cyclophosphamid | Gustave Roussy, Cancer Campus, Grand Paris, PHRC, Solving Kids' Cancer Europe, Neuroblastoma UK, , BSPHO, Instituto de Investigación Sanitaria La Fe, Deutsche Krebshilfe | High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy | 11/26 | 11/32 | | |
| Recruiting | 3 | 6430 | Europe, RoW | Omitted Doxorubicin, Omitted Vincristine+Dexamethasone pulses, Inotuzumab Ozogamicin+Standard Maintenance Therapy, Besponsa+Maintenance Therapy, Imatinib, 6-tioguanine+Standard Maintenance Therapy, Blinatumomab, Blincyto | Mats Heyman, The Swedish Research Council, The Swedish Childhood Cancer Foundation, Pfizer, Servier, NordForsk, Aamu Pediatric Cancer Foundation, German Society for Pediatric Oncology and Hematology GPOH gGmbH, Clinical Trial Center North (CTC North GmbH & Co. KG), Belgium Health Care Knowledge Centre, Karolinska Institutet, Cancer Research UK, Fundação Rui Osório de Castro, Acreditar - Associação de Pais e Amigos das Crianças com Cancro, Grupo Português De Leucemias Pediátricas, Amgen, Nova Laboratories Limited, Danish Child Cancer Foundation, Danish Cancer Society, The Novo Nordic Foundation, Assistance Publique - Hôpitaux de Paris, Direction Générale de l'Offre de Soins | Leukemia, Acute Lymphoblastic | 06/27 | 06/32 | | |
| Recruiting | 3 | 409 | Europe | Everolimus, VOTUBIA, AFINITOR, ONC201, Radiotherapy | Gustave Roussy, Cancer Campus, Grand Paris, Chimerix, Innovative Therapies For Children with Cancer Consortium, Ministry of Health, France | Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant | 09/28 | 09/31 | | |
| Recruiting | 2/3 | 536 | Europe, RoW | 16 weeks of VEC + CDDP, Vincristine, Etoposide, Cyclophosphamide, Cisplatin, VEC + HD-MTX, Methotrexate, Chemotherapy + Valproate, Carboplatin, Valproate, Conformal radiotherapy, VEC, Chemotherapy, conformal radiotherapy +/- boost | Centre Leon Berard | Childhood Ependymoma | 06/28 | 08/31 | | |
| Recruiting | 2/3 | 225 | Europe | Melphalan or Melphalan + Topotecan, Alkeran, Topotecan Accord; Topotecan Hospira chemotherapy, etoposide, carboplatin and vincristine or local ophthalmological treatment without IV chemotherapy, etoposide, carboplatin and vincristine chemotherapy, Carboplatin administered on Day 1, platinum-based chemotherapy, Thermotherapy (local treatment), Thermotherapy after carboplatin administered on Day 1, Cryotherapy (local treatment), Iodine-125 plaques (local treatment), Intravitreal Melphalan chemotherapy injections (local treatment) | Institut Curie, Fondation Rothschild Paris | Retinoblastoma | 01/35 | 01/36 | | |
| Active, not recruiting | 2 | 133 | Europe | VP16, carboplatin, etoposide, vepesid, chemotherapy, Melphalan, Alkeran, chemotherapy, VP16, carboplatin, vincristin, etoposide, vepesid, leurocristine, Oncovin, chemotherapy, Carboplatin + laser day 1 (chemothermotherapy), Carbo-laser, platinum-based chemotherapy, Laser (local treatment), Laser diode, cryoapplication (local treatment), I125 radioactive plaques (local treatment), intravitreal Melphalan (local treatment) | Institut Curie, Fondation Rothschild Paris | Retinoblastoma, Children, Retinal Neoplasm | 01/23 | 09/35 | | |
| Recruiting | 2 | 185 | Europe | Observation, Low risk group, Etoposide, Intermediate risk sub group 1, Vincristine, Intermediate risk sub group 2, Orbital irradiation, High risk group, Carboplatin, Cyclophosphamide, Thiotepa, Cytapheresis, Peripheral bood stem cell transplantation | Institut Curie | Retinoblastoma | 03/30 | 09/30 | | |
| Recruiting | 2 | 134 | Europe | Trametinib, Vinblastine | University Hospital, Strasbourg, France | Grade 1 Glioma, Mixed Glio-neuronal Tumors, Pleomorphic Xanthoastrocytoma | 11/31 | 12/31 | | |
| Recruiting | N/A | 300 | Europe, RoW | Collection of blood sample or saliva, Collection of a tumor sample taken before the participation of the patient in study, Collection of blood sample if tumor sample is not available | University Hospital, Angers | Predisposition, Genetic, Cancer Childhood, Development Delay | 02/25 | 08/25 | | |
SACHA, NCT04477681: Securing Access to Innovative Molecules in Oncology and Hematology for Children, Adolescents and Young Adults |
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| Recruiting | N/A | 1000 | Europe | Data collection | Gustave Roussy, Cancer Campus, Grand Paris, Société Française des Cancers de l'Enfant (SFCE) | Pediatric Cancer | 04/26 | 04/27 | | |
| Recruiting | N/A | 160 | Europe | Data collection | University Hospital, Brest, Fondation de France, Fondation Apicil | Neuropathic Pain, Chronic Pain | 05/27 | 09/27 | | |
| Active, not recruiting | N/A | 2093 | Europe, RoW | Hydroxycarbamide, Siklos, Hydroxyurea | Theravia, International Clinical Trials Association | Sickle Cell Disease | 08/25 | 08/25 | | |
MICCHADO, NCT03496402: Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults |
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| Active, not recruiting | N/A | 600 | Europe | Sampling on blood, bone marrow and cerebrospinal fluid | Institut Curie | Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma Family of Tumors, Osteosarcoma, Leukemia, Central Nervous System Tumor | 04/27 | 08/27 | | |
| TORNY, Frédéric |
| Recruiting | N/A | 100 | Europe | CSF, blood and urine sampling, clinical measures of disease severity and progression | University Hospital, Bordeaux | Parkinsonian Syndromes, Parkinson's Disease, Multiple System Atrophy, Progressive Supranuclear Palsy | 12/23 | 12/25 | | |
| Oudot, Caroline |
CAALL-F01, NCT02716233: A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents |
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| Recruiting | 3 | 1578 | Europe | pegaspargase 1250 IU/m2 x 2, ONCASPAR 1250 IU/m2 x 2, pegaspargase 2500 IU/m2 x 1, ONCASPAR 2500 IU/m2 x 1 | Assistance Publique - Hôpitaux de Paris, Shire | Acute Lymphoblastic Leukemia | 04/26 | 04/26 | | |
CURALASE01, NCT04596410: Photobiomodulation Protocols in the Analgesia of Chemotherapy-induced Oral Mucositis in Children |
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| Recruiting | N/A | 406 | Europe | LLLT applied every other day, LLLT applied daily | University Hospital, Toulouse | Mucositis Oral | 01/24 | 02/24 | | |
| Recruiting | N/A | 4000 | Europe, Canada, RoW | | PedNet Haemophilia Research Foundation, Lund University Hospital | Factor VIII Deficiency, Factor IX Deficiency | 12/29 | 12/29 | | |
| Sandison, Taylor |
ReSPECT, NCT04368559 / 2017-004981-85: Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation |
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| Recruiting | 3 | 600 | Europe, Canada, US, RoW | Rezafungin for Injection, Intravenous antifungal therapy, Posaconazole, Noxafil, Fluconazole, Generic Fluconazole, Trimethoprim-sulfamethoxazole (TMP/SMX), Bactrim, Septra, Intravenous Placebo, Placebo Infusion, Oral Placebo, encapsulated cellulose | Mundipharma Research Limited | Candidemia, Mycoses, Fungal Infection, Fungemia, Invasive Candidiasis, Pneumocystis, Mold Infection, Invasive Fungal Disease, Prophylaxis of Invasive Fungal Infections, Aspergillus | 12/25 | 12/25 | | |
NAVIGATE, NCT06609460: Study of CD388 for the Prevention of Influenza in Subjects Not at Risk for Influenza Complications |
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| Active, not recruiting | 2 | 5000 | Europe, US | CD388 Injection, Placebo | Cidara Therapeutics Inc. | Influenza | 09/25 | 09/25 | | |
| Daix, Thomas |
| Recruiting | 3 | 270 | Europe | Placebos, Dobutamine | University Hospital, Limoges, Centre d'Investigation Clinique 1415 | Sepsis, Cardiomyopathies, Hypoperfusion, Left Ventricular Systolic Dysfunction | 12/25 | 12/25 | | |
NCT04612413: A Phase 2 Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients |
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| Active, not recruiting | 2 | 160 | Europe, RoW | Allocetra-OTS, Placebo | Enlivex Therapeutics Ltd., Cato Research, Accelsiors CRO & Consultancy Services | Sepsis, Community-acquired Pneumonia, Urinary Tract Infections, Cholecystitis, Acute, Cholangitis Acute, Intraabdominal Infections | 12/24 | 03/25 | | |
COMPACT, NCT05671159: COMPArative Study of the Consequence on innaTe Immune Response du to Bacterial or Viral Infection in Patients Admitted to Intensive Care Unit |
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| Recruiting | N/A | 38 | Europe | Blood sample | University Hospital, Limoges | Viral Infection, Sepsis | 02/26 | 02/26 | | |
PROCESS, NCT05621850: Impact of CErebral Endovascular PROcedures on the Systemic Immune responSe Response |
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| Recruiting | N/A | 78 | Europe | Blood sample | University Hospital, Limoges | Cerebral Arterio-venous Malformation | 12/25 | 12/25 | | |
| Recruiting | N/A | 20000 | Europe, RoW | VAP | European Clinical Research Alliance for Infectious Diseases (ECRAID), Centre Hospitalier Universitaire Dupuytren de Limoges (CHUL), Université de Genève (UNIGE), University Medical Center Utrecht (UMCU) | Ventilator Associated Pneumonia | 12/25 | 03/26 | | |
| Completed | N/A | 2165 | Europe, RoW | | UMC Utrecht, Universiteit Antwerpen, University Hospital, Geneva | Hospital-acquired Pneumonia, Ventilator Associated Pneumonia | 05/22 | 01/23 | | |
| Jacques, Jérémie |
FAMCAP, NCT02738359: Efficacy of Colonoscopy, Colon Capsule and Fecal Immunological Test for Colorectal Cancer Screening |
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| Recruiting | N/A | 3250 | Europe | optical colonoscopy, colon capsule endoscopy, fecal immunological test (FIT) | Hôpital Edouard Herriot, National Cancer Institute, France, Medtronic | Colon Cancer, Rectum Cancer | 11/21 | 11/24 | | |
| Completed | N/A | 111 | Europe | | University Hospital, Bordeaux | Achalasia | 02/24 | 02/24 | | |
COLODETECT2, NCT05594576: Comparison of the ENDOCUFF VISION® Endoscopy Cap Coupled with GI GENIUS™ Artificial Intelligence Compared to Each Device Alone in Improving Colonic Adenoma Detection Rate During Colonoscopy |
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| Recruiting | N/A | 483 | Europe | GI GENIUS™ artificial intelligence system, ENDOCUFF VISION® endoscopic cap | Centre Hospitalier Universitaire de Nīmes, University Hospital, Limoges | Colorectal Cancer, Adenoma, Intestinal Polyps | 10/24 | 11/24 | | |
ENDOBARRETT, NCT04867590: A Study Comparing the Effectiveness of EndoRotor Versus Radiofrequency in Treating Barrett's Esophagus |
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| Recruiting | N/A | 140 | Europe | Endorotor, Radiofrequency | University Hospital, Angers | Barrett Esophagus, Dysplasia | 03/26 | 05/27 | | |
| Recruiting | N/A | 1500 | Europe | | University Hospital, Limoges | Cancer Colorectal, Polyps Colorectal, Endoscopic Submucosal Resection | 12/20 | 12/23 | | |
| MARCHAND-ADAM, Sylvain |
| Recruiting | 4 | 378 | Europe | pirfenidone and nintedanib, pirfenidone or nintedanib | Hospices Civils de Lyon, Ministry of Health | Progressive Idiopathic Pulmonary Fibrosis | 01/26 | 01/26 | | |
| Terminated | 3 | 372 | Europe, US, RoW | Pamrevlumab, FG-3019, Placebo | FibroGen | Idiopathic Pulmonary Fibrosis | 09/23 | 09/23 | | |
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| Completed | 3 | 397 | Europe, Canada, Japan, US, RoW | GSK3511294, Depemokimab, Placebo | GlaxoSmithKline, Iqvia Pty Ltd | Asthma | 04/24 | 04/24 | | |
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| Active, not recruiting | 3 | 1667 | Europe, Canada, Japan, US, RoW | GSK3511294 (Depemokimab), Mepolizumab, Benralizumab, Placebo, Standard of care (SoC), Pre-filled Syringes (PFS) | GlaxoSmithKline, Iqvia Pty Ltd | Asthma | 10/25 | 10/25 | | |
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EvER-ILD2, NCT05596786: Evaluation of Efficacy and Safety of Rituximab in Patients With Progressive Interstitial Lung Disease (ILD) With Inflammatory Component: a Multicentre Double-blind Placebo-controlled Randomized Trial |
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| Recruiting | 3 | 126 | Europe | Rituximab, Placebo | University Hospital, Tours | Lung Diseases | 07/26 | 07/26 | | |
EXPOSOMFPI, NCT04619199: Influence of Socioeconomic and Environmental Factors on the Natural History of Idiopathic Pulmonary Fibrosis |
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| Recruiting | N/A | 200 | Europe | Blood sample | Assistance Publique - Hôpitaux de Paris, Institut National de la Santé Et de la Recherche Médicale, France | Idiopathic Pulmonary Fibrosis, Pulmonary Disease, Pulmonary Medicine | 04/22 | 04/25 | | |
| Completed | N/A | 19 | Europe | 24h urine, urine sample | University Hospital, Tours | Lymphangioleiomyomatosis, Tuberous Sclerosis Complex | 10/22 | 10/22 | | |
| Recruiting | N/A | 350 | Europe | Blood samples, Tracheal Aspirates, Surplus of Broncho-alveolar lavage fluid | University Hospital, Tours | Community-acquired Pneumonia, Acute Respiratory Distress Syndrome, Innate Immunity | 09/24 | 03/25 | | |
| JOUAN, Youenn |
| Recruiting | 3 | 270 | Europe | Placebos, Dobutamine | University Hospital, Limoges, Centre d'Investigation Clinique 1415 | Sepsis, Cardiomyopathies, Hypoperfusion, Left Ventricular Systolic Dysfunction | 12/25 | 12/25 | | |
| Completed | N/A | 7 | Europe | serology testing profiles description, biomarkers, immune response characterization, in vivo brain PET-TSPO acquisitions, brain MRI assessment, neurocognitive assessment | University Hospital, Toulouse, Institut National de la Santé Et de la Recherche Médicale, France | Covid19, Delirium, Post-traumatic Stress Disorder | 06/22 | 06/22 | | |
| Recruiting | N/A | 350 | Europe | Blood samples, Tracheal Aspirates, Surplus of Broncho-alveolar lavage fluid | University Hospital, Tours | Community-acquired Pneumonia, Acute Respiratory Distress Syndrome, Innate Immunity | 09/24 | 03/25 | | |
| Not yet recruiting | N/A | 150 | Europe | | University Hospital, Tours | Viral Pneumonia, Acute Respiratory Distress Syndrome (ARDS) | 02/29 | 02/29 | | |
| BALLOUHEY, Julia |
LaparoDAN, NCT04174807: Prospective Study of Antenatal Diagnostic Criteria for Digestive Complications of Gastroschisis |
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| Recruiting | N/A | 200 | Europe, RoW | | University Hospital, Angers | Gastroschisis, Intestinal Occlusion | 05/22 | 05/22 | | |
| Gauthier |
MISC-TRAIN, NCT06647849: Interest of Simulation Training on the Announcement of Early Pregnancy Loss on the Psychological Impact of the Patients |
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| Recruiting | N/A | 1000 | Europe | centers whose interns receive simulation training in the announcement of early spontaneous miscarriage between the 2 inclusion phases, centers with standard in-house management of spontaneous miscarriage/pregnancy arrested in the emergency department | University Hospital, Angers, Direction Générale de l'Offre de Soins | Early Pregnancy Loss, Spontaneous Miscarriage | 05/25 | 06/26 | | |
| CARCOPINO-TUSOLI |
MISC-TRAIN, NCT06647849: Interest of Simulation Training on the Announcement of Early Pregnancy Loss on the Psychological Impact of the Patients |
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| Recruiting | N/A | 1000 | Europe | centers whose interns receive simulation training in the announcement of early spontaneous miscarriage between the 2 inclusion phases, centers with standard in-house management of spontaneous miscarriage/pregnancy arrested in the emergency department | University Hospital, Angers, Direction Générale de l'Offre de Soins | Early Pregnancy Loss, Spontaneous Miscarriage | 05/25 | 06/26 | | |
