| Mayer-Davis, Elizabeth |
ACME, NCT03379792: The Influence of Glycemic Control and Obesity on Energy Balance and Metabolic Flexibility in Type 1 Diabetes |
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| Completed | N/A | 32 | US | DEXA, MRI, CGM, Whole room calorimeters, Dietary counseling | AdventHealth Translational Research Institute | Type 1 Diabetes | 07/20 | 07/20 | | |
NCT05147324: "MyPlan" - Individualized Planned Eating Patterns for Adolescents With Type 1 Diabetes |
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| Completed | N/A | 52 | US | "MyPlan" - Individualized Planned Eating Pattern, "MyPlan" | University of North Carolina, Chapel Hill, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Cincinnati | Type 1 Diabetes | 04/23 | 04/23 | | |
NCT05701657: Nutrition for Precision Health, Powered by the All of Us |
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| Recruiting | N/A | 8000 | US | Diet A, Diet B, Diet C, Liquid Mixed Meal Tolerance Test, LMMTT, Diet-Specific Mixed Meal Tolerance Test, Diet-Specific MMTT | RTI International, National Institutes of Health (NIH), University of North Carolina, Chapel Hill, Northwestern University, Illinois Institute of Technology, University of Chicago, Pennington Biomedical Research Center, Louisiana State University Health Sciences Center in New Orleans, University of California, Davis, University of California, Los Angeles, Cedars-Sinai Medical Center, University of Alabama at Birmingham, Tufts University, Massachusetts General Hospital, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Center for Advancing Translational Sciences (NCATS), National Cancer Institute (NCI), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), City University of New York, School of Public Health, Mayo Clinic, University of California, San Diego, University of Hawaii, Vanderbilt University Medical Center, National Heart, Lung, and Blood Institute (NHLBI), National Center for Complementary and Integrative Health (NCCIH), National Institute of Drug Abuse, Public Health Informatics Computational and Operations Research, University of Southern California, Cornell University, University of Alabama, Tuscaloosa, North Carolina State University, University of North Carolina, Charlotte, Duke University, Stevens Institute of Technology, Purdue University, United States Military Academy at West Point, USDA, Western Human Nutrition Research Center, North Carolina Central University, Wake Forest University Health Sciences, Boston University, Children's Hospital of Richmond, Virginia Commonwealth University, Verily Life Sciences LLC, Indiana University, Fred Hutchinson Cancer Center, Columbia University, University of Pennsylvania | Nutrition, Health, Dietary Habits | 12/26 | 01/27 | | |
| Smith, Steven R |
NCT06246396: Antihypertensive Mechanisms of Minocycline in Resistant Hypertension |
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| Recruiting | 4 | 120 | US | Minocycline Hydrochloride, Minocycline, Minocin, Placebo | University of Florida, Emory University, National Heart, Lung, and Blood Institute (NHLBI) | Hypertension, Resistant to Conventional Therapy | 07/28 | 07/28 | | |
NCT05026866: A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3) |
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| Active, not recruiting | 3 | 2196 | Japan, US | Donanemab, LY3002813, Placebo | Eli Lilly and Company | Alzheimer Disease | 11/27 | 11/27 | | |
ISIS, NCT02463240: Determine the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of 463588 |
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| Active, not recruiting | 2 | 15 | US | ISIS 463588, Placebo, 0.9% Sterile saline | Translational Research Institute for Metabolism and Diabetes, Florida, Isis Pharmaceuticals | Obesity | 10/16 | | | |
NCT00977457: Genetic Testing in Predicting Biomarkers of Recurrence in Patients With Prostate Cancer Undergoing Surgery |
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| Active, not recruiting | 1 | 1045 | US | DNA analysis, DNA methylation analysis, RNA analysis, gene expression analysis, polymerase chain reaction, diagnostic laboratory biomarker analysis, therapeutic conventional surgery, Undergo robotic prostatectomy or cystoprostatectomy | City of Hope Medical Center, National Cancer Institute (NCI) | Prostate Cancer | 07/16 | 12/24 | | |
NCT02817659: To Determine Tolerability to Glucagon Infusion in Obese Subjects |
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| Active, not recruiting | 1 | 20 | US | Glucagon | AdventHealth Translational Research Institute | Obesity | 01/17 | 12/24 | | |
NCT03139305: Effect of Prolonged (72 Hour) Glucagon Administration on Energy Expenditure in Healthy Obese Subjects |
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| Active, not recruiting | 1 | 30 | US | Glucagon, Placebo | AdventHealth Translational Research Institute | Obesity | 02/18 | 12/24 | | |
MCC-21113, NCT05316129: Infusion of Autologous T Cells Engineered to Target FSH Receptor in Recurrent Ovarian Cancer |
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| Recruiting | 1 | 48 | US | Follicle Stimulating Hormone Receptor T Cells | H. Lee Moffitt Cancer Center and Research Institute, Anixa Biosciences, Inc. | Ovarian Cancer | 03/25 | 03/29 | | |
NCT06313528: A Study to Measure Calorie Consumption and Usage in Participants With Obesity Using LY3437943 |
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| Recruiting | 1 | 74 | US | LY3437943, Placebo | Eli Lilly and Company | Obesity | 10/25 | 10/25 | | |
| Active, not recruiting | N/A | 56 | US | Exercise | AdventHealth Translational Research Institute, Sanford-Burnham Medical Research Institute, Takeda | Obesity, Disorder of Lipid Storage and Metabolism, Lipid Metabolism Disorders, Metabolic Disorder | 12/14 | 12/24 | | |
| Active, not recruiting | N/A | 36 | US | | AdventHealth Translational Research Institute, Sanford-Burnham Medical Research Institute, Pennington Biomedical Research Center, Boston University, Tufts University | Polycystic Ovary Syndrome, Metabolic Diseases, Overweight | 02/15 | 12/24 | | |
NCT01441687: Comparing the Reliability of Expressed Prostatic Secretion (EPS) and Post Massage Urine (PMU) for the Prediction of Prostate Cancer Biopsy Outcome |
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| Active, not recruiting | N/A | 243 | US | laboratory biomarker analysis, transrectal prostate biopsy | City of Hope Medical Center, National Cancer Institute (NCI) | Conditions Influencing Health Status, Healthy, Prostate Cancer | 06/16 | 12/24 | | |
| Active, not recruiting | N/A | 27 | US | Dual-energy X-ray absorptiometry (DEXA)/ Magnetic resonance imaging (MRI) and Magnetic resonance spectroscopy (MRS), Adipose tissue biopsies, FSIGTT/ RMR | AdventHealth Translational Research Institute, Sanford-Burnham Medical Research Institute | Obesity | 12/24 | 12/24 | | |
| Active, not recruiting | N/A | 108 | US | DEXA, Magnetic Resonance (MR) Assessment of the Abdomen, MR assessment of Whole Body Fat, Adipose tissue biopsy, Oral glucose tolerance test | AdventHealth Translational Research Institute | PCOS | 12/25 | 12/25 | | |
DAC, NCT05379348: Davos Alzheimer's Collaborative Study: Sequential Administration of Digital Testing To Screen For Cognitive Impairment Followed By Blood Based Biomarkers To Assist With Timely Detection And Accurate Diagnosis Of Alzheimer's Disease |
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| Active, not recruiting | N/A | 1423 | US | Cognitive Assessment, MoCA | AdventHealth Translational Research Institute, Davos Alzheimer's Collaborative | Alzheimer Disease | 12/24 | 12/24 | | |
NCT01827527: Magnetic Resonance & Optical Spectroscopy Validation |
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| Recruiting | N/A | 150 | US | | AdventHealth Translational Research Institute | Validation Studies, Magnetic Resonance Spectroscopy | 12/24 | 12/24 | | |
| Maahs, David M |
| Active, not recruiting | 3 | 319 | US | Afrezza, Technosphere Insulin, Rapid-acting Insulin Analog, insulin aspart, insulin lispro, insulin glulisine, Novolog®, Fiasp®, Humalog®, Admelog®, Apidra®, Basal Insulin, insulin glargine, insulin degludec, insulin detemir, Lantus®, Abasaglar®, Basaglar®, Semglee®, Toujeo®, Tresiba®, Levemir® | Mannkind Corporation, Jaeb Center for Health Research | Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2 | 10/24 | 05/25 | | |
SUGARNSALT, NCT06217302: Sotagliflozin to Slow Kidney Function Decline in Persons with Type 1 Diabetes and Diabetic Kidney Disease |
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| Recruiting | 3 | 150 | Canada, US | Sotagliflozin, INPEFA, Placebo | Alessandro Doria, Canadian Institutes of Health Research (CIHR), The Kidney Foundation of Canada, The Cleveland Clinic, University of Michigan, University of Colorado, Denver, Northwestern University, Washington University School of Medicine, State University of New York - Upstate Medical University, Providence Medical Research Center, Stanford University, Montefiore Medical Center, University of Toronto, University Health Network, Toronto, University of Calgary, University of Alberta, University of British Columbia, Institut de Recherches Cliniques de Montreal, LMC Diabetes & Endocrinology Ltd., Joslin Diabetes Center, Lexicon Pharmaceuticals, DexCom, Inc., University of Washington, Breakthrough T1D | Diabetic Nephropathies, Kidney Failure, Chronic, Diabetes Mellitus Type 1, Heart Failure | 12/28 | 05/29 | | |
| Terminated | 2 | 13 | US | Latiglutenase, IMGX003, Placebo | Entero Therapeutics, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Immunogenics, LLC | Celiac Disease | 12/22 | 12/22 | | |
MMPPC, NCT02480309: A Probabilistic Closed-loop Artificial Pancreas to Handle Unannounced Meals and Exercise |
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| Recruiting | N/A | 20 | US | Inpatient use of the MMPPC/DiAs system, Outpatient use of the MMPPC/DiAs system | University of Colorado, Denver, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Type 1 Diabetes | 03/17 | 03/17 | | |
ACME, NCT03379792: The Influence of Glycemic Control and Obesity on Energy Balance and Metabolic Flexibility in Type 1 Diabetes |
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| Completed | N/A | 32 | US | DEXA, MRI, CGM, Whole room calorimeters, Dietary counseling | AdventHealth Translational Research Institute | Type 1 Diabetes | 07/20 | 07/20 | | |
| Completed | N/A | 32796 | US | ECHO Tele-Education | University of Florida | Type 1 Diabetes, Type 2 Diabetes | 06/22 | 12/23 | | |
| Recruiting | N/A | 5000 | US | CGM and RPM | Stanford University | Type1diabetes | 01/26 | 01/26 | | |
NCT04336969: Teamwork, Targets, Technology, and Tight Control in Newly Diagnosed Pediatric T1D - 4T Study |
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| Enrolling by invitation | N/A | 500 | US | 4T Education and Care | Stanford University, National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Type1diabetes | 05/25 | 12/26 | | |
| Pratley, Richard E |
| Completed | 2 | 110 | US | Placebo, MBX-2982, Study Medication (MBX-2982), No medication for this group | AdventHealth Translational Research Institute | Diabetes Mellitus, Type 1 | 08/23 | 08/23 | | |
| Active, not recruiting | 2 | 140 | Europe, US, RoW | Ladarixin, allosteric inhibitor of CXCL8 (IL-8), CXCR1 and CXCR2 receptors, Placebo | Dompé Farmaceutici S.p.A, Dompe farmaceutici s.p.a. | Recent Onset type1 Diabetes | 04/24 | 04/26 | | |
| Recruiting | 1 | 150 | US | Cholecalciferol, vitamin D3, Placebo pill | Translational Research Institute for Metabolism and Diabetes, Florida, Tufts Medical Center | Pre-diabetic, Hyperglycemia, Type 2 Diabetes | 10/17 | | | |
miRNA, NCT02459106: Effect of AT-derived on the Biology and Insulin Sensitivity of Skeletal Muscle in Humans |
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| Active, not recruiting | N/A | 100 | US | | AdventHealth Translational Research Institute | Type 2 Diabetes Mellitus | 01/17 | 12/24 | | |
NCT03032627: Identifying Targets of Maladaptive Metabolic Responses in Heart Failure |
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| Active, not recruiting | N/A | 55 | US | Collection of discarded heart tissue | AdventHealth Translational Research Institute, Florida Hospital Cardiovascular Institute, Sanford-Burnham Medical Research Institute | Heart Failure | 06/19 | 12/24 | | |
ACME, NCT03379792: The Influence of Glycemic Control and Obesity on Energy Balance and Metabolic Flexibility in Type 1 Diabetes |
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| Completed | N/A | 32 | US | DEXA, MRI, CGM, Whole room calorimeters, Dietary counseling | AdventHealth Translational Research Institute | Type 1 Diabetes | 07/20 | 07/20 | | |
| Recruiting | N/A | 20 | US | | AdventHealth Translational Research Institute | Type 1 Diabetes | 12/24 | 12/24 | | |
| Recruiting | N/A | 66 | US | | AdventHealth Translational Research Institute | Covid19, Diabetes | 12/24 | 12/24 | | |
DREAM-ON, NCT06401577: Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics |
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| Not yet recruiting | N/A | 800 | US | Dexcom Continuous Glucose Monitor (CGM) | Milton S. Hershey Medical Center, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Benaroya Research Institute, Cedars-Sinai Medical Center, University of Southern California, Indiana University, Johns Hopkins University, Ohio State University, Stanford University, University of Florida, AdventHealth, University of Illinois at Chicago, Northwestern University, University of Minnesota, University of Pittsburgh | Acute Pancreatitis | 12/26 | 03/27 | | |
| Not yet recruiting | N/A | 324 | Europe, US, RoW | Omnipod 5 or Medtronic 780G, My HypoCOMPaSS Education, HARPdoc Education | Milton S. Hershey Medical Center, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Minnesota, University of Kentucky, University of Pennsylvania, AdventHealth, University of Leicester, University of Sheffield, University of Melbourne, Jaeb Center for Health Research, University of California, San Diego | Diabetes Mellitus, Type 1 | 06/27 | 12/27 | | |
| Recruiting | N/A | 800 | US | | Milton S. Hershey Medical Center, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Benaroya Research Institute, Cedars-Sinai Medical Center, University of Southern California, Indiana University, Johns Hopkins University, Ohio State University, Stanford University, University of Florida, AdventHealth, University of Illinois at Chicago, Northwestern University, University of Minnesota, University of Pittsburgh | Acute Pancreatitis | 04/25 | 04/25 | | |
NCT02531607: Lipidomics, Proteomics, Micro RNAs and Volatile Organic Compounds (VOC) |
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| Active, not recruiting | N/A | 500 | US | blood and bile | AdventHealth | Pancreatic Neoplasms | 12/25 | 12/25 | | |
| Goodpaster, Bret H |
ABA, NCT04722354: Abscisic Acid Effects on Glucose Homeostasis and Insulin Sensitivity |
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| Active, not recruiting | 2 | 48 | US | Hyperinsulemic euglycemic clamp, Muscle Biopsy, Oral abscisic acid (ABA), Placebo | AdventHealth Translational Research Institute, BioTherapeutics Inc. | Pre Diabetes | 12/24 | 12/24 | | |
| Completed | 2 | 223 | US | Aerobic exercise, Perindopril, Losartan, HCTZ | University of Alabama at Birmingham, University of Colorado, Denver, AdventHealth Translational Research Institute | Hypertension, Aging, Sedentary Lifestyle | 09/24 | 09/24 | | |
NCT02238600: Evaluation of a Complete Oral Nutritional Supplement on Lean Body Mass in Healthy Older Subjects During Bed Rest and Recovery |
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| Recruiting | 1 | 30 | US | Oral Nutritional Supplement | Translational Research Institute for Metabolism and Diabetes, Florida, Abbott Nutrition | Sarcopenia | 09/15 | | | |
| | N/A | 120 | US | Exercise training protocol, cardio, resistance training, Dietary, diet, nutrition, Educational control., education, behavioral | University of Pittsburgh, National Institute on Aging (NIA) | Aging | 09/16 | 09/16 | | |
EXPET, NCT04754581: Dynamic in Vivo PET Imaging and ex Vivo Biopsies From Skeletal Muscle and Adipose Tissue to Investigate the Effects of Exercise on Insulin Resistance and Mitochondrial Energetics in Type 2 Diabetes |
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| Recruiting | N/A | 12 | US | Maximal ATP Production (ATPmax), Exercise Testing (VO2max), Muscle Biopsy, Adipose Tissue Biopsy, Hyperinsulinemic euglycemic clamp, PET imaging | AdventHealth Translational Research Institute | Type 2 Diabetes | 06/25 | 06/25 | | |
| Active, not recruiting | N/A | 200 | US | Exercise, Energy Restriction-Induced Weight Loss | AdventHealth Translational Research Institute | Insulin Resistance, Sarcopenia | 12/24 | 12/24 | | |
| Recruiting | N/A | 20 | US | Exercise Test | AdventHealth Translational Research Institute | Cutaneous Melanoma, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma | 05/25 | 05/25 | | |
| Divoux, Adeline |
| Active, not recruiting | N/A | 36 | US | | AdventHealth Translational Research Institute, Sanford-Burnham Medical Research Institute, Pennington Biomedical Research Center, Boston University, Tufts University | Polycystic Ovary Syndrome, Metabolic Diseases, Overweight | 02/15 | 12/24 | | |
| Xie, Hui |
| Not yet recruiting | N/A | 60 | RoW | Endostar, S1 | Peking University Third Hospital, Mianyang Central Hospital, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing Cancer Hospital, Peking University International Hospital, China-Japan Friendship Hospital, The fifth medical center of PLA general hospital, Second Hospital of Shanxi Medical University, Hiser Medical Center of Qingdao, Guangxi Ruikang Hospital, GEM flower hospital of Liaohe oil field, Tang-Du Hospital, Third Affiliated Hospital of Guizhou Medical University, Liuzhou Worker's Hospital, The Affiliated Hospital of Xuzhou Medical University, Dalian municipal central hospital affiliated of dalian medical university | Radiotherapy Side Effect | 01/22 | 01/23 | | |
| Cornnell, Heather |
NCT01827527: Magnetic Resonance & Optical Spectroscopy Validation |
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| Recruiting | N/A | 150 | US | | AdventHealth Translational Research Institute | Validation Studies, Magnetic Resonance Spectroscopy | 12/24 | 12/24 | | |
MRS VALIDATION, NCT02663362: Development and Validation of Multi-nuclear Magnetic Resonance Imaging and Spectroscopy for Whole Body Human Applications |
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| Recruiting | N/A | 250 | US | To evaluate the reproducibility of acquiring multi-nuclear data on a new 3T Philips Magnet | AdventHealth Translational Research Institute | Human Body Composition, Human Body Function | 01/26 | 01/27 | | |
| Coen, Paul |
BATSR, NCT04168580: Brown Adipose Tissue as a Therapeutic for the Metabolic and Cardiac Dysfunction With Senescence |
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| Recruiting | 1/2 | 30 | US | Exercise Training Intervention | AdventHealth Translational Research Institute | Metabolic Diseases | 12/24 | 12/24 | | |
NCT04999488: Impact of Orally Administered BPM31510 on Mitochondrial Energetics in Older Adults With Sarcopenia |
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| Withdrawn | 1 | 40 | US | BPM31510, Placebo | AdventHealth Translational Research Institute | Sarcopenia | 12/24 | 12/24 | | |
| Active, not recruiting | N/A | 24 | US | Maximal oxygen consumption (V02 max), Brown adipose tissue (BAT) imaging, Muscle function testing | AdventHealth Translational Research Institute | Aging | 05/19 | 12/24 | | |
RECOVER, NCT04057677: Exercise Training as an Intervention to Improve Muscle Function and Recovery Following Bed Rest in Older Adults With Type 2 Diabetes |
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| Active, not recruiting | N/A | 12 | US | Bed Rest Intervention, Exercise Program | AdventHealth Translational Research Institute | Type 2 Diabetes, Muscular Atrophy, Sedentary Behavior, Exercise, Pre-diabetes | 05/23 | 12/24 | | |
| Active, not recruiting | N/A | 75 | US | Muscle Tissue Biopsy, Maximal Oxygen Consumption (V02max) | AdventHealth Translational Research Institute | Sarcopenia | 12/24 | 12/24 | | |
REST, NCT03761446: The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults |
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| Recruiting | N/A | 50 | US | Bed rest | AdventHealth Translational Research Institute | Type 2 Diabetes, Muscle Atrophy, Aging, Sedentary Behavior, Pre-diabetes | 12/24 | 12/24 | | |
| Casu, Anna |
| Active, not recruiting | N/A | 25 | US | Mixed Meal Test, Dual Energy X-Ray Absorptiometry (DEXA), Adipose Tissue Biopsy | AdventHealth Translational Research Institute | Diabetes | 11/21 | 12/24 | | |
| Not yet recruiting | N/A | 324 | Europe, US, RoW | Omnipod 5 or Medtronic 780G, My HypoCOMPaSS Education, HARPdoc Education | Milton S. Hershey Medical Center, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Minnesota, University of Kentucky, University of Pennsylvania, AdventHealth, University of Leicester, University of Sheffield, University of Melbourne, Jaeb Center for Health Research, University of California, San Diego | Diabetes Mellitus, Type 1 | 06/27 | 12/27 | | |
| Corbin, Karen |
| Terminated | N/A | 57 | US | Inulin, Placebo | AdventHealth Translational Research Institute | NAFLD | 06/21 | 06/21 | | |
| Active, not recruiting | N/A | 38 | US | Sigmoidoscopy | AdventHealth Translational Research Institute | Non-Alcoholic Fatty Liver Disease | 03/23 | 12/24 | | |
AVAIL, NCT04807868: AdventHealth Research Institute Non-Alcoholic Fatty Liver Disease Biobank and Registry |
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| Recruiting | N/A | 1250 | US | Standard of care liver biopsy, Fibroscan, Biospecimen Collection | AdventHealth Translational Research Institute, Berg, LLC | Non-Alcoholic Fatty Liver Disease | 12/24 | 03/26 | | |
| Sparks, Lauren |
| Active, not recruiting | N/A | 84 | US | Exercise | AdventHealth Translational Research Institute, American Diabetes Association | Type 2 Diabetes | 01/17 | 06/25 | | |
NCT02274805: Collection of Human Tissue Samples From the Neck Region for Characterization of Its Molecular and Biochemical Signatures |
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| Active, not recruiting | N/A | 34 | US | Adults presenting for surgery in the neck area | AdventHealth Translational Research Institute | Obesity | 04/19 | 12/24 | | |
BIO-AGE, NCT05989035: Effects of MetAP2 Inhibition on Bioenergetics and Aging-associated Characteristics in Adipose Tissue in Healthy Participants |
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| Active, not recruiting | N/A | 31 | US | Abdominal subcutaneous adipose tissue biopsy | AdventHealth Translational Research Institute | Aging | 03/21 | 12/24 | | |
| Recruiting | N/A | 132 | Europe | | Maastricht University Medical Center | Healthy, Obesity, Type 2 Diabetes Mellitus | 03/24 | 03/24 | | |
MoTrMyo, NCT04334343: Investigating the Effects of Aerobic and Resistance Training in Vivo on Skeletal Muscle Metabolism in Vitro in Primary Human Muscle Cells |
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| Recruiting | N/A | 400 | US | Additional Muscle Biopsy Collection | AdventHealth Translational Research Institute, Wake Forest University | Physical Activity | 12/24 | 12/24 | | |
ATLAS, NCT06602141: Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise |
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| Recruiting | N/A | 70 | US | Muscle Biopsy, Adipose Biopsy, Glucose Clamp, Accelerometer, Endurance Exercise, Physical activity/ dietary habits, Heavy Water Labeling Period | AdventHealth Translational Research Institute, Pennington Biomedical Research Center | Obesity | 04/29 | 04/29 | | |
| Martinez, Celines |
NCT02238600: Evaluation of a Complete Oral Nutritional Supplement on Lean Body Mass in Healthy Older Subjects During Bed Rest and Recovery |
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| Recruiting | 1 | 30 | US | Oral Nutritional Supplement | Translational Research Institute for Metabolism and Diabetes, Florida, Abbott Nutrition | Sarcopenia | 09/15 | | | |
| Recruiting | 1 | 150 | US | Cholecalciferol, vitamin D3, Placebo pill | Translational Research Institute for Metabolism and Diabetes, Florida, Tufts Medical Center | Pre-diabetic, Hyperglycemia, Type 2 Diabetes | 10/17 | | | |
| Krajmalnik-Brown, Rosa |
NCT06321796: Microbiota Transfer Therapy for Children and Adults With Both Pitt Hopkins Syndrome and Gastrointestinal Disorders |
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| Recruiting | 2 | 20 | US | MTP-101P, Vancomycin, Magnesium Citrate, Antacid, Placebo MTP-101P, Placebo Vancomycin | Gut-Brain-Axis Therapeutics Inc., Pitt Hopkins Research Foundation | Pitt Hopkins Syndrome | 02/25 | 05/25 | | |
| Manager, Recruitment |
NCT05644093: IM and IV SPL026 Drug Product in Healthy Participants |
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| Completed | 1 | 14 | Europe | SPL026 IV, DMT, SPL026 IM | Small Pharma Ltd | Major Depressive Disorder | 04/23 | 04/23 | | |
NCT05478278: An Evaluation of Psilocybin's Effect on Cardiac Repolarization and the Effect of Food on Psilocybin's Pharmacokinetics |
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| Completed | 1 | 60 | US | Psilocybin, Psilocybine, Psilocibin, Indocybin, Moxifloxacin, Avelox, Moxeza, Micro-Crystalline Cellulose | Usona Institute | QTc Interval, Pharmacokinetics | 08/23 | 08/23 | | |
NCT05698095: Pharmacokinetics, Safety, and Tolerability of Intramuscular 5-MeO-DMT in Healthy Volunteers |
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| Completed | 1 | 54 | US | 5-methoxy-N,N-dimethyltryptamine succinate salt, 5-MeO-DMT succinate salt, 5-MeO-DMT, Placebo, 0.9% sodium chloride solution (USP) | Usona Institute | Pharmacokinetics, Safety, Tolerability | 09/23 | 09/23 | | |
| Recruiting | N/A | 656 | US | Ovaprene | Daré Bioscience, Inc., Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Contraception | 06/25 | 09/25 | | |
MRS VALIDATION, NCT02663362: Development and Validation of Multi-nuclear Magnetic Resonance Imaging and Spectroscopy for Whole Body Human Applications |
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| Recruiting | N/A | 250 | US | To evaluate the reproducibility of acquiring multi-nuclear data on a new 3T Philips Magnet | AdventHealth Translational Research Institute | Human Body Composition, Human Body Function | 01/26 | 01/27 | | |
| Department, Recruitment |
| Completed | 2 | 110 | US | Placebo, MBX-2982, Study Medication (MBX-2982), No medication for this group | AdventHealth Translational Research Institute | Diabetes Mellitus, Type 1 | 08/23 | 08/23 | | |
ABA, NCT04722354: Abscisic Acid Effects on Glucose Homeostasis and Insulin Sensitivity |
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| Active, not recruiting | 2 | 48 | US | Hyperinsulemic euglycemic clamp, Muscle Biopsy, Oral abscisic acid (ABA), Placebo | AdventHealth Translational Research Institute, BioTherapeutics Inc. | Pre Diabetes | 12/24 | 12/24 | | |
BATSR, NCT04168580: Brown Adipose Tissue as a Therapeutic for the Metabolic and Cardiac Dysfunction With Senescence |
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| Recruiting | 1/2 | 30 | US | Exercise Training Intervention | AdventHealth Translational Research Institute | Metabolic Diseases | 12/24 | 12/24 | | |
NCT05881993: Study of CBP-4888 in Healthy, Non-Pregnant Female Subjects |
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| Recruiting | 1 | 15 | US | CBP-4888, Placebo | Comanche Biopharma | Healthy Volunteer Study | 03/24 | 04/24 | | |
CASINO, NCT05662865: Low-CArbohydrate Diet and SGLT2-INhibitOr to Achieve Moderate Ketosis in Healthy Volunteers |
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| Recruiting | 1 | 8 | US | SGLT2 inhibitor, ertugliflozin, Controlled, Adaptive Study Diet | AdventHealth Translational Research Institute | Ketones, Metabolism | 12/24 | 12/24 | | |
| Completed | 1 | 25 | US | Ecopipam tablet | Emalex Biosciences Inc. | Food-effect | 12/24 | 12/24 | | |
| Terminated | N/A | 57 | US | Inulin, Placebo | AdventHealth Translational Research Institute | NAFLD | 06/21 | 06/21 | | |
| Active, not recruiting | N/A | 38 | US | Sigmoidoscopy | AdventHealth Translational Research Institute | Non-Alcoholic Fatty Liver Disease | 03/23 | 12/24 | | |
| Recruiting | N/A | 20 | US | | AdventHealth Translational Research Institute | Type 1 Diabetes | 12/24 | 12/24 | | |
EXPET, NCT04754581: Dynamic in Vivo PET Imaging and ex Vivo Biopsies From Skeletal Muscle and Adipose Tissue to Investigate the Effects of Exercise on Insulin Resistance and Mitochondrial Energetics in Type 2 Diabetes |
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| Recruiting | N/A | 12 | US | Maximal ATP Production (ATPmax), Exercise Testing (VO2max), Muscle Biopsy, Adipose Tissue Biopsy, Hyperinsulinemic euglycemic clamp, PET imaging | AdventHealth Translational Research Institute | Type 2 Diabetes | 06/25 | 06/25 | | |
REST, NCT03761446: The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults |
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| Recruiting | N/A | 50 | US | Bed rest | AdventHealth Translational Research Institute | Type 2 Diabetes, Muscle Atrophy, Aging, Sedentary Behavior, Pre-diabetes | 12/24 | 12/24 | | |
| Recruiting | N/A | 66 | US | | AdventHealth Translational Research Institute | Covid19, Diabetes | 12/24 | 12/24 | | |
DAC, NCT05379348: Davos Alzheimer's Collaborative Study: Sequential Administration of Digital Testing To Screen For Cognitive Impairment Followed By Blood Based Biomarkers To Assist With Timely Detection And Accurate Diagnosis Of Alzheimer's Disease |
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| Active, not recruiting | N/A | 1423 | US | Cognitive Assessment, MoCA | AdventHealth Translational Research Institute, Davos Alzheimer's Collaborative | Alzheimer Disease | 12/24 | 12/24 | | |
NCT01827527: Magnetic Resonance & Optical Spectroscopy Validation |
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| Recruiting | N/A | 150 | US | | AdventHealth Translational Research Institute | Validation Studies, Magnetic Resonance Spectroscopy | 12/24 | 12/24 | | |
AVAIL, NCT04807868: AdventHealth Research Institute Non-Alcoholic Fatty Liver Disease Biobank and Registry |
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| Recruiting | N/A | 1250 | US | Standard of care liver biopsy, Fibroscan, Biospecimen Collection | AdventHealth Translational Research Institute, Berg, LLC | Non-Alcoholic Fatty Liver Disease | 12/24 | 03/26 | | |
MoTrMyo, NCT04334343: Investigating the Effects of Aerobic and Resistance Training in Vivo on Skeletal Muscle Metabolism in Vitro in Primary Human Muscle Cells |
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| Recruiting | N/A | 400 | US | Additional Muscle Biopsy Collection | AdventHealth Translational Research Institute, Wake Forest University | Physical Activity | 12/24 | 12/24 | | |
ATLAS, NCT06602141: Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise |
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| Recruiting | N/A | 70 | US | Muscle Biopsy, Adipose Biopsy, Glucose Clamp, Accelerometer, Endurance Exercise, Physical activity/ dietary habits, Heavy Water Labeling Period | AdventHealth Translational Research Institute, Pennington Biomedical Research Center | Obesity | 04/29 | 04/29 | | |
| Recruiting | N/A | 45 | US | Whole Room Calorimeter, Mixed-Meal Tolerance Test (MMTT), Core Body Temperature, Morningness-Eveningness Questionnaire, Muscle Biopsy, Serial Blood Sampling | AdventHealth Translational Research Institute | Metabolic Health | 03/25 | 03/26 | | |
| Recruiting | N/A | 20 | US | Exercise Test | AdventHealth Translational Research Institute | Cutaneous Melanoma, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma | 05/25 | 05/25 | | |
