| VELLAS, Bruno |
LO-MAPT, NCT03691519: Prevention of Cognitive Decline in Older Adults With Low Dha/Epa Index in Red Blood Cells |
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| Completed | 3 | 774 | Europe | Omega-3 treatment, Dietary intervention, Placebo | University Hospital, Toulouse | Alzheimer Disease | 03/20 | 03/20 | | |
PERSON-AL, NCT04820127: Personalized Management of Psycho-behavioral Symptoms in Alzheimer's Disease: Impact on Health Resources Use |
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| Recruiting | N/A | 668 | Europe | personalized care preceded by a standardized assessment | University Hospital, Toulouse | Alzheimer's Disease | 10/24 | 10/24 | | |
ICOPE Fr, NCT06676839: Effectiveness of the WHO ICOPE (Integrated Care for Older People) Program in Preventing Age-related Functional Decline: a 36-month Randomized Controlled Trial with a 24-month Extension: (ICOPE Trial.Fr) |
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| Recruiting | N/A | 1000 | Europe | the complete ICOPE program | University Hospital, Toulouse | Ageing | 10/31 | 10/31 | | |
| Active, not recruiting | N/A | 345 | Europe | MRI and PET scan | University Hospital, Toulouse, MSDAVENIR | Frail Elderly | 01/26 | 12/26 | | |
| Recruiting | N/A | 1000 | Europe | The Inspire Bio-resource Research Platform for Healthy Aging | University Hospital, Toulouse, European Regional Development Fund | Biological Aging | 10/31 | 10/33 | | |
| GAC, Yann TANGUY LE |
| Not yet recruiting | N/A | 444 | Europe | Magnetic resonance imaging- Positron Emission Tomography (MRI-PET) examination, blood sample, urine collection, Collection of a lock of hair, questionnaire | Hospices Civils de Lyon | Implant Complication, Contraceptive Device; Complications | 08/31 | 06/36 | | |
| Recruiting | N/A | 214 | Europe | Anterior colporraphy, vaginal patch plastron | University Hospital, Limoges | Prolapse, Vaginal | 09/25 | 03/28 | | |
| BREFEL-COURBON, Christine |
| Active, not recruiting | 3 | 134 | Europe | Apomorphine, Apokinon, Best Medical Treatment | Rennes University Hospital | Parkinson's Disease | 12/23 | 01/25 | | |
NCT03940872: Primary Parkinsonian Pain Diagnostic Questionnaire: Development and Validation of This Questionnaire |
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| Completed | N/A | 227 | Europe | Self-questionnaire 3PDQ | University Hospital, Toulouse | Parkinson Disease | 12/22 | 12/22 | | |
| Completed | N/A | 30 | Europe | reflexology massage, sham massage | University Hospital, Toulouse | Parkinson Disease | 05/23 | 05/23 | | |
GlutaTour, NCT03681795: Exploration of Glutamatergic System With PET Radiotracer in Gilles de la Tourette Patients: Pilot Study |
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| Recruiting | N/A | 24 | Europe | Experimental MRI exam and PET scan exam with radiotracer | University Hospital, Toulouse | Tourette Syndrome | 12/23 | 12/24 | | |
| Recruiting | N/A | 100 | Europe | CSF, blood and urine sampling, clinical measures of disease severity and progression | University Hospital, Bordeaux | Parkinsonian Syndromes, Parkinson's Disease, Multiple System Atrophy, Progressive Supranuclear Palsy | 12/23 | 12/25 | | |
| Completed | N/A | 100 | Europe | TCI, BPI, CPAQ-8, SF-MPQ, King's Parkinson's Disease Pain Scale (KPPS), Hospital Anxiety and Depression scale (HAD) questionary, PCS, ORT, Social Support Questionnaire (SSQ6), IPQ-R, WCC-R | University Hospital, Toulouse | Parkinson Disease | 04/24 | 04/24 | | |
PD-Pain, NCT06008704: Pain in Parkinson's Disease: Exploration of the Serotonin System in Positron Emission Tomography (PET [18F]-MPPF) |
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| Recruiting | N/A | 34 | Europe | Clinical assessment, Pain characteristics assessment, MRI, Thermotest, UPDRS-III Scale, [18F]-MPPF PET scan | University Hospital, Toulouse | Parkinson Disease | 09/26 | 09/26 | | |
| RASCOL, Olivier |
BouNDless, NCT04006210 / 2018-004156-37: Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations |
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| Active, not recruiting | 3 | 381 | Europe, US, RoW | ND0612 Solution for SC infusion, Placebo for SC infusion, Oral IR-LD/CD, IR-LD/CD, Placebo for Oral IR-LD/CD, Placebo for IR-LD/CD | NeuroDerm Ltd. | Parkinson's Disease | 11/22 | 02/27 | | |
LIGHTHOUSE, NCT05418673 / 2022-000747-77: A Study to Assess if BIIB122 Tablets Are Safe and Can Slow Worsening of Early-Stage Parkinson's Disease in Participants With Specific LRRK2 Genetic Variants Between the Ages of 30 and 80 Using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale |
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| Terminated | 3 | 7 | Europe, US | BIIB122, DNL151, BIIB122-Matching Placebo | Biogen, Denali Therapeutics Inc. | Parkinson Disease | 07/23 | 07/23 | | |
| Recruiting | 3 | 152 | Europe | SPECT, PET | Zionexa | Parkinson Disease, Essential Tremor | 09/24 | 12/24 | | |
| Completed | 3 | 507 | Europe, US, RoW | Tavapadon, PF-06649751, CVL-751, Placebo | Cerevel Therapeutics, LLC | Parkinson Disease | 01/24 | 02/24 | | |
| Completed | 3 | 304 | Europe, US, RoW | Tavapadon, PF-06649751, CVL-751, Placebo | Cerevel Therapeutics, LLC | Parkinson Disease | 10/24 | 10/24 | | |
PIMPARK, NCT03947216: Randomized Placebo Controlled Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease. |
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| Completed | 2 | 117 | Europe | Active drug: pimavanserin 17mg (2 strength tablets), Placebo: 2 tablets containing same excipients except active compound, Assessment of severity of ICD (impulse control disorders), Assessment of motor and non-motors symptoms of PD Evaluation of hyper- and hypodopaminergic behaviors, Assessment of quality of life, Assessment of depression, Assessment of cognition, Assessment of severity of Parkinson Disease, Blood analysis, Cardiac monitoring | University Hospital, Strasbourg, France, NS-PARK, EUCLID Clinical Trial Platform, F-CRIN, ACADIA Pharmaceuticals Inc. | Parkinson Disease | 04/24 | 06/24 | | |
| Active, not recruiting | 2 | 159 | Europe, Japan, US | TAK-341, MEDI1341, Placebo | Takeda, AstraZeneca | Multiple System Atrophy | 07/25 | 07/25 | | |
LUMA, NCT05348785 / 2021-004849-20: A Study to Assess the Safety of BIIB122 Tablets and if it Can Slow the Worsening of Early-Stage Parkinson's Disease in Participants Between the Ages of 30 and 80 |
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| Recruiting | 2 | 640 | Europe, Canada, Japan, US, RoW | BIIB122, DNL151, BIIB122-Matching Placebo | Biogen, Denali Therapeutics Inc. | Parkinson Disease | 12/25 | 12/25 | | |
ACTIVATE, NCT05819359: Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD |
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| Active, not recruiting | 2 | 237 | Europe, Canada, US | BIA 28-6156 10 mg, BIA 28-6156 60 mg, Placebo | Bial R&D Investments, S.A. | Parkinson's Disease | 03/26 | 07/26 | | |
| Completed | N/A | 72 | Europe | Questionnaire | University Hospital, Toulouse | Parkinson Disease | 07/21 | 07/21 | | |
| Not yet recruiting | N/A | 50 | Europe | Narrative interviews | University Hospital, Toulouse | Parkinson Disease | 12/21 | 12/22 | | |
| Completed | N/A | 61 | Europe | MRI acquisition, DAT-SPECT, blood sample, cerebrospinal fluid (optional), Evaluations about motor abilities, depression, cognition and lifestyle, Evaluation about depression cognition | University Hospital, Toulouse | Multiple System Atrophy | 05/22 | 10/22 | | |
| Recruiting | N/A | 100 | Europe | CSF, blood and urine sampling, clinical measures of disease severity and progression | University Hospital, Bordeaux | Parkinsonian Syndromes, Parkinson's Disease, Multiple System Atrophy, Progressive Supranuclear Palsy | 12/23 | 12/25 | | |
| Not yet recruiting | N/A | 90 | Europe | connected smartwatch | University Hospital, Toulouse, European Union, University Hospital Carl Gustav Carus, Aristotle University Of Thessaloniki | Parkinson Disease | 07/25 | 07/25 | | |
RETRO-PIMPARK, NCT06754553: Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease. |
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| Not yet recruiting | N/A | 100 | Europe | Assessment of severity of ICD (impulse control disorders), Assessment of motor and non-motors symptoms of PD Evaluation of hyper- and hypodopaminergic behaviors, Assessment of quality of life, Assessment of depression, Assessment of cognition, Assessment of severity of Parkinson Disease, Cardiac monitoring | University Hospital, Strasbourg, France, NS-PARK Network, EUCLID Clinical Trial Platform, F-CRIN | Parkinson Disease | 02/26 | 02/26 | | |
| Completed | N/A | 100 | Europe | TCI, BPI, CPAQ-8, SF-MPQ, King's Parkinson's Disease Pain Scale (KPPS), Hospital Anxiety and Depression scale (HAD) questionary, PCS, ORT, Social Support Questionnaire (SSQ6), IPQ-R, WCC-R | University Hospital, Toulouse | Parkinson Disease | 04/24 | 04/24 | | |
| PAUL, Carle |
METVI, NCT04237103: Combination of Methotrexate and Phototherapy Versus Phototherapy in Adults with Progressive Vitiligo |
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| Recruiting | 2 | 45 | Europe | Methotrexate, narrow-band UVB phototherapy, Placebos | University Hospital, Bordeaux | Vitiligo | 10/25 | 10/25 | | |
PREPCOV, NCT04481633: Efficacy of Pre-exposure Treatment With Hydroxy-Chloroquine on the Risk and Severity of COVID-19 Infection |
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| Recruiting | N/A | 800 | Europe | COVID 19 serology, COVID 19 Self-Questionnaire | University Hospital, Toulouse | COVID-19 | 03/22 | 03/22 | | |
ADlupus, NCT06506214: Characterizing Adherence to Treatment and Satisfaction With Care in Patients With Cutaneous Lupus |
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| Recruiting | N/A | 233 | Europe | Questionnaires | University Hospital, Toulouse | Cutaneous Lupus | 10/24 | 10/24 | | |
| Decramer, Stéphane |
| Active, not recruiting | 3 | 75 | Japan, US, RoW | Daprodustat | GlaxoSmithKline, GlaxoSmithKline Research & Development Limited, GSK Research & Development Limited | Anaemia | 07/30 | 07/30 | | |
| Not yet recruiting | 2/3 | 72 | Europe | ADV7103, Placebo | Advicenne Pharma | Cystinuria | 05/25 | 06/25 | | |
NCT04006808 / 2019-000607-33: A Study to Test GlaxoSmithKline's (GSK) Candidate Vaccine-GSK1437173A for Prevention of Shingles in Children With Kidney Transplant |
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| Recruiting | 2 | 184 | Europe | PED-HZ/su | GlaxoSmithKline | Herpes Zoster | 03/24 | 02/25 | | |
GYN-HNF1, NCT04746053: Ovarian Function and Gynecological Profile of Patients Carrying a Pathogenic Variant of the HNF1B Gene |
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| Completed | N/A | 26 | Europe | Pelvic ultrasound, blood sample | University Hospital, Toulouse | Genital Diseases, Female | 10/23 | 10/23 | | |
Antenatal, NCT03116217: Validation of a Fetal Urine Peptidome-based Classifier to Predict Post-natal Renal Function in Posterior Urethral Valves |
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| Recruiting | N/A | 400 | Europe | | University Hospital, Toulouse, Institut National de la Santé Et de la Recherche Médicale, France | Posterior Urethral Valves | 12/23 | 12/23 | | |
| Recruiting | N/A | 50 | Europe, RoW | Blood sampling | Hospices Civils de Lyon | Nephropathic Cystinosis | 10/24 | 10/24 | | |
| BUREAU, Christophe |
ProPILARifax, NCT03069131: Two Strategies of Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Severe Cirrhotic Patients With Ascites |
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| Completed | 3 | 160 | Europe | Rifaximin, Placebo | Centre Hospitalier Universitaire de Besancon, Alfasigma S.p.A., LC2 PHARMA | Cirrhosis, Ascites, Peritonitis | 06/22 | 03/23 | | |
NATiV3, NCT04849728: A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( ) |
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| Recruiting | 3 | 1000 | Europe, Canada, US, RoW | IVA337, Lanifibranor, Placebo | Inventiva Pharma | NASH - Nonalcoholic Steatohepatitis | 09/25 | 09/26 | | |
DHELIVER, NCT04229901: Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF) |
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| Terminated | 2 | 133 | Europe, RoW | HepaStem, Placebo | Cellaion SA | Acute on Chronic Liver Failure | 05/24 | 05/24 | | |
| Recruiting | 2 | 50 | Europe, US | INT-787, Placebo | Intercept Pharmaceuticals, Intercept Pharmaceuticals, Inc. | Alcohol Associated Hepatitis | 12/24 | 03/25 | | |
NCT03695796: French Cohort for the Study of Non-invasive Tests of Liver Lesions in NAFLD/NASH (FreSH Cohort) |
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| Recruiting | N/A | 1000 | Europe | biopsy-proven NAFLD patients with non-invasive tests of liver fibrosis (blood tests, elastography devices) and biobank | University Hospital, Angers | NAFLD | 11/24 | 12/24 | | |
ARIAPUMP, NCT03506893: Medical-economic Evaluation of the Care of Refractory Ascites by Implantation of Alfapump® Device in Cirrhotic Patients |
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| Recruiting | N/A | 90 | Europe | Alphapump, Ascites puncture | University Hospital, Grenoble | Ascites, Paracentesis, Cirrhosis | 12/22 | 12/25 | | |
| Completed | N/A | 104 | Europe | Transjugular Portosytemic Shunt (TIPS), glue obliteration | Centre Hospitalier Universitaire de Besancon | Bleeding Gastric Varices, Cirrhosis | 03/23 | 02/24 | | |
POEME, NCT05206487: Hepatic Encephalopathy Prevention With Polydextrose After TIPS: Pilot Study |
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| Recruiting | N/A | 30 | Europe | Polydextrose | University Hospital, Toulouse, Société nationale française de gastro-entérologie | Hepatic Encephalopathy | 06/25 | 06/25 | | |
Quali-SAT, NCT04779593: Impact of Transferrin Saturation Guided Maintenance Treatment on Quality of Life in HFE Haemochromatosis |
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| Recruiting | N/A | 240 | Europe | Clinical examination, SF36 questionnaire, AIMS2_SF questionnaire, WOMAC questionnaire, EQ-5D-5L questionnaire, Blood Sample Complete blood count, Blood Sample Iron panel, Blood Sample Fasting Glucose, Blood sample lipid panel, Blood sample liver panel, Blood sample C reactive protein, Bloodletting - control group, BioBank, Medico-economical, Bloodletting - experimental group | Rennes University Hospital | Haemochromatosis | 01/27 | 01/27 | | |
| Not yet recruiting | N/A | 150 | Europe | Corticosteroid therapy | Assistance Publique - Hôpitaux de Paris | Liver Failure, Acute, Hepatitis, Autoimmune, Organ Dysfunction Scores, Risk Factors | 05/27 | 06/28 | | |
NCT04615091: Non-invasive Methods and Surgical Risk Stratification in Cirrhotics Undergoing Elective Extrahepatic Surgery |
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| Recruiting | N/A | 250 | Europe, Canada, US, RoW | | Azienda Ospedaliera Universitaria Integrata Verona | Advanced Chronic Liver Disease, Surgery--Complications | 10/21 | 08/22 | | |
| Senard, Jean-Michel |
| Recruiting | 4 | 90 | Europe | Fludrocortisone, Flucortac, Placebo | H.A.C. PHARMA, H.A.C. Pharma | Neurogenic Orthostatic Hypotension | 06/24 | 06/24 | | |
| Thalamas, Claire |
CORELIA, NCT03464344: Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. |
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| Recruiting | N/A | 170 | Europe | neurological, neuropsychological and MRI evaluation | University Hospital, Toulouse | Cerebral Amyloid Angiopathy | 02/23 | 02/25 | | |
| Recruiting | N/A | 62 | Europe | Overnight polysomnography, blood sample, high-resolution MRI scan, neuropsychological evaluation | University Hospital, Toulouse, Centre de Recherches sur la Cognition Animale (CRCA - UMR5169 CNRS/UPS), Centre de Recherche Cerveau & Cognition (CerCo - UMR5549 CNRS/UPS), Toulouse NeuroImaging Center (ToNIC - UMR 1214 Inserm/UPS), Fondation Plan Alzheimer, IHNPS/FHU HoPeS | Alzheimer Disease, Early Onset | 06/23 | 06/23 | | |
| Recruiting | N/A | 60 | Europe | Cerebral neuroinflammation evaluation | University Hospital, Toulouse, Institut National de la Santé Et de la Recherche Médicale, France | Depressive Disorder | 01/24 | 01/24 | | |
| Huynh, Anne |
| Active, not recruiting | 3 | 66 | Europe | MaaT013 | MaaT Pharma, MaaT Pharma | Acute Graft Versus Host Disease in Intestine, Steroid Refractory GVHD | 11/24 | 11/25 | | |
| Recruiting | 3 | 210 | Europe | MC0518, BAT | medac GmbH | Steroid-refractory Acute Graft-versus-host Disease | 08/27 | 08/30 | | |
Predictor2, NCT03887156: Evaluation of a Donor Testing Kit for the Prediction of AGVHD in Patient Receiving a Peripheral Blood Stem Cell Allograft |
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| Recruiting | 2/3 | 227 | Europe | Ex vivo capacities of CD4neg INkT expansion of the peripheral blood donor with the Predictor test | Assistance Publique - Hôpitaux de Paris, SATT, SNC Graft Versus Host Disease, Imagine Institute, Axonal-Biostatem, CERBA laboratory | Acute Myeloid Leukemia in Remission, Lymphoma in Remission, Non-progressive Myeloproliferative Syndrome, Myelodysplasia With Stable Blasts is Cell Number and < 10% of Blastocysts, Acute Leukemia Biphenotypic in Remission, Acute Lymphoblastic Leukemia | 03/23 | 03/23 | | |
| Active, not recruiting | 2 | 57 | Europe | ASTX727, Donor Lymphocyte Infusions, DLI | Groupe Francophone des Myelodysplasies, Astex Pharmaceuticals, Inc. | MDS, AML | 04/24 | 04/25 | | |
| Recruiting | 2 | 150 | Europe | Fecal Microbiota Transplantation | University Hospital, Clermont-Ferrand, Ministry of Health, France, French Society of Hematology | Acute Leukemia in Remission, Myelodysplastic Syndromes, Myeloproliferative Syndrome, Hodgkin Lymphoma, Lymphoma, Non-Hodgkin, Myeloma, Chronic Lymphocytic Leukemia | 10/26 | 12/27 | | |
PHOEBUS, NCT05762211: Oral Pooled Fecal Microbiotherapy to Prevent Allogeneic Hematopoietic Cell Transplantation Complications ( Trial) |
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| Recruiting | 2 | 387 | Europe | Pooled allogeneic fecal microbiotherapy, MaaT033, Placebo | MaaT Pharma | Transplant Complication | 10/26 | 02/27 | | |
HAPLO-EMPTY, NCT05126849: Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation With Post-transplant Cyclophosphamide in Patients With Acquired Refractory Aplastic Anemia or in Relapse After Immunosuppression |
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| Recruiting | 2 | 31 | Europe | Allogenic transplantation | Assistance Publique - Hôpitaux de Paris | Refractory Idiopathic Aplastic Anemia, Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation | 01/27 | 01/27 | | |
FLUCLORIC, NCT05917405: Study Comparing the Efficacy of 2 RIC Regimens (Clofarabine vs Fludarabine) in Adults With AML Eligible to Allo-SCT |
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| Recruiting | 2 | 302 | Europe | Fludarabine, Busulfan, ATG, Clofarabine | Nantes University Hospital | Acute Myeloid Leukemia in Remission | 09/28 | 09/28 | | |
HTLP-ONCO, NCT04707300 / 2019-004883-23: Study Evaluating the Safety and the Efficacy of Human T Lymphoid Progenitor (HTLP) Injection to Accelerate Immune Reconstitution After Umbilical Cord Blood (UCB) Transplantation in Adult Patients with Hematologic Malignancies |
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| Recruiting | 1/2 | 10 | Europe | Human T Lymphoid Progenitor (HTLP) injection | Assistance Publique - Hôpitaux de Paris | Hematologic Malignancy | 11/25 | 08/27 | | |
| Recruiting | 1/2 | 40 | Europe | Allogeneic T cell progenitors, cultured ex-vivo, SMART101 | Smart Immune SAS, SMART IMMUNE | Hematological Malignancies | 07/25 | 07/26 | | |
| Recruiting | 1/2 | 55 | Europe | venetoclax + azacitidine +/- donor lymphocyte infusion, venclyxto, vidaza | Groupe Francophone des Myelodysplasies, AbbVie | MDS, AML | 09/25 | 03/26 | | |
AMA-ALLO, NCT04323605: Assistance Program for Outpatients Following an Allogeneic Hematopoietic Stem-cell Transplant |
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| Not yet recruiting | N/A | 50 | Europe | Outpatient assistance program for transplant patients (AMA-ALLO) based on a "navigation" nurse | University Hospital, Toulouse | Hematologic Neoplasms | 01/22 | 02/22 | | |
| MINVILLE, Vincent |
| Recruiting | N/A | 702 | Europe | No ventilation with face mask, Ventilation with face mask | Nantes University Hospital | Morbid Obesity, Ventilation Therapy; Complications | 09/25 | 09/25 | | |
OPTI-TWO, NCT05893030: Prevention of Organ Dysfunction and Mortality by Monitoring the Administration of Opioids and Hypnotics in Patients at High Postoperative Risk |
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| Recruiting | N/A | 1132 | Europe | anesthesia guided by sedation and analgesia monitoring, anesthesia performed according only to the clinical judgment of the anesthetist as usual practice | Centre Hospitalier Universitaire de Saint Etienne, Direction Générale de l'Offre de Soins | Sedation and Analgesia Monitoring | 01/27 | 12/27 | | |
| PROBST, Vincent |
CPVT, NCT06005428: Effectiveness of CRD-4730 in Participants with Catecholaminergic Polymorphic Ventricular Tachycardia |
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| Recruiting | 2 | 12 | Europe, Canada, US | CRD-4730, Placebo | Cardurion Pharmaceuticals, Inc. | CPVT1, Heart Defects, Congenital, Heart Diseases, Ventricular Tachycardia | 07/25 | 09/25 | | |
| Recruiting | 2 | 120 | Europe | Spironolactone, Placebo | Hospices Civils de Lyon | Arrhythmogenic Right Ventricular Dysplasia | 12/27 | 12/29 | | |
RIDGE-1, NCT06228924: Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC |
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| Recruiting | 1 | 15 | US | TN-401 | Tenaya Therapeutics, Johns Hopkins University, Mayo Clinic | Arrhythmogenic Right Ventricular Cardiomyopathy | 05/26 | 10/29 | | |
NCT03884426: Genetic and Phenotypic Characteristics of Mitral Valve Prolapse |
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| Recruiting | N/A | 1000 | Europe | | Nantes University Hospital, University Hospital, Brest, Rennes University Hospital | Mitral Valve Prolapse, Genetic Disease | 12/21 | 12/21 | | |
NCT02881671: Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms |
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| Recruiting | N/A | 2600 | Europe | genetic blood analysis | Nantes University Hospital | Congenital Complete Heart Block, Cardiac Conduction Defect Progressive | 12/21 | 12/21 | | |
NCT02922517: Predictive Factors and Consequences of Myocardial Fibrosis in Hypertrophic Cardiomyopathy |
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| Recruiting | N/A | 115 | Europe | | Nantes University Hospital, University Hospital, Lille, Rennes University Hospital, Institut National de la Santé Et de la Recherche Médicale, France | Hypertrophic Cardiomyopathy | 12/21 | 12/21 | | |
PRIME, NCT04715256: Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients. |
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| Recruiting | N/A | 100 | Europe | Cognitive assessment of obsessive-compulsive and impulsive behaviours, Genomic analysis, Glucoregulation assessment | Biotrial, European Union, Nantes University Hospital | Romano-Ward Syndrome, Long QT Syndrome, Compulsive Behavior, Healthy Individuals | 12/21 | 12/21 | | |
RIDGE, NCT06311708: Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) |
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| Recruiting | N/A | 200 | Europe, US | | Tenaya Therapeutics, University of California, San Francisco, Brigham and Women's Hospital, New York University, University of Colorado, Denver, Johns Hopkins University, The Cleveland Clinic, Mayo Clinic, Medical University of South Carolina, Hopital Louis Pradel, Istituti Clinici Scientifici Maugeri SpA, The Queen Elizabeth Hospital, St George's University Hospitals NHS Foundation Trust, Royal Brompton & Harefield NHS Foundation Trust, Barts & The London NHS Trust, Skane University Hospital, Centro Cardiologico Monzino, Hôpital Haut-Lévêque, Nantes University Hospital, Pitié-Salpêtrière Hospital, Wuerzburg University Hospital, University Hospital Muenster | Arrhythmogenic Right Ventricular Cardiomyopathy | 03/30 | 07/30 | | |
| Recruiting | N/A | 206 | Europe | Pacemaker implantation | MicroPort CRM | Bradycardia, Remote Monitoring | 09/23 | 07/27 | | |
OPALE, NCT03058185: Observatoire Des Patients Atteints de Laminopathies et Emerinopathies (Observatory for PAtients With Laminopathies and Emerinopathies) |
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| Recruiting | N/A | 800 | Europe | | Pitié-Salpêtrière Hospital, Institute of Myology, Assistance Publique - Hôpitaux de Paris, Institut National de la Santé Et de la Recherche Médicale, France | Laminopathies, Emerinopathies | 07/33 | 07/33 | | |
NCT04619888: HeartLogic France Study: Heart Failure Patients Managed With the HeartLogic Algorithm |
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| Recruiting | N/A | 310 | Europe | HeartLogic | Poitiers University Hospital | Heart Failure | 07/23 | 07/23 | | |
FEMQT, NCT04328376: Measurement of the Electromechanical Window to Improve the Diagnosis of Congenital Long QT Syndrome |
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| Completed | N/A | 224 | Europe | ECG coupled to phonocardiography | University Hospital, Bordeaux | Long QT Syndrome | 04/24 | 04/24 | | |
RESOUDRE, NCT06642168: Sudden Cardiac Arrest Related to Sport in Young and Value of the Genetic Assessment: a French Prospective Register |
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| Recruiting | N/A | 80 | Europe | Whole exome sequencing to detect myocardial genetic mutations (SCA group only) | Rennes University Hospital | Sudden Cardiac Arrest, Sudden Cardiac Death | 01/28 | 01/28 | | |
| Recruiting | N/A | 600 | Europe | | Nantes University Hospital, Institut National de la Santé Et de la Recherche Médicale, France, Centre National de la Recherche Scientifique, France | Long QT Syndrome | 03/25 | 03/25 | | |
DILEMMA, NCT05373940: Cardioverter DefIbriIlator PlacEMent for priMary Prevention of Sudden cArdiac Death in Patients Older Than 70 Years |
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| Recruiting | N/A | 730 | Europe | ICD implantation, No ICD implantation | Assistance Publique - Hôpitaux de Paris, Ministry of Health, France | Heart Failure, Primary Prevention of Sudden Cardiac Death, Implantable Cardioverter Defibrillator | 05/30 | 05/30 | | |
NCT06048731: Enlighten Study: The EV-ICD Post Approval Registry |
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| Recruiting | N/A | 1000 | Europe, Canada, US, RoW | Defibrillation using EV-ICD | Medtronic | Ventricular Arrhythmia, Tachycardia | 05/30 | 10/37 | | |
| OUSSET, Pierre-Jean |
| Terminated | 3 | 1027 | Europe, Canada, Japan, US, RoW | Aducanumab, BIIB037, Aducanumab-avwa, Aduhelm, Placebo | Biogen, Biogen Idec Research Limited | Alzheimer's Disease | 08/24 | 08/24 | | |
| Recruiting | 3 | 1500 | Europe, RoW | Donanemab, (LY3002813), Placebo | Eli Lilly and Company | Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Tauopathies, Neurodegenerative Diseases, Neurocognitive Disorders, Mental Disorders | 04/27 | 04/27 | | |
| Recruiting | 2 | 282 | Europe, Canada, US, RoW | GSK4527226, Placebo | GlaxoSmithKline, Alector Inc. | Alzheimer's Disease | 12/26 | 02/29 | | |
CELIA, NCT05399888: A Study to Learn About the Safety of BIIB080 Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age |
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| Active, not recruiting | 2 | 416 | Europe, Canada, Japan, US, RoW | BIIB080, ISIS 814907, BIIB080-matching placebo | Biogen | Mild Cognitive Impairment Due to Alzheimer's Disease, Alzheimer's Disease Dementia | 05/26 | 01/29 | | |
PERSON-AL, NCT04820127: Personalized Management of Psycho-behavioral Symptoms in Alzheimer's Disease: Impact on Health Resources Use |
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| Recruiting | N/A | 668 | Europe | personalized care preceded by a standardized assessment | University Hospital, Toulouse | Alzheimer's Disease | 10/24 | 10/24 | | |
| Recruiting | N/A | 1000 | Europe | | University Hospital, Toulouse, France Alzheimer | Alzheimer Disease | 06/26 | 01/27 | | |
| ARBUS, Christophe |
| Recruiting | N/A | 64 | Europe | Electroconvulsive therapy | Centre Hospitalier du Rouvray, University Hospital, Rouen, University Hospital, Bordeaux, Nantes University Hospital, University Hospital, Toulouse, University Hospital, Caen, Centre Hospitalier Henri Laborit, Centre Hospitalier St Anne, Centre Hospitalier de Cadillac, Hôpital Louis Mourier, University Hospital, Montpellier, University Hospital, Clermont-Ferrand, Centre hospitalier de Ville-Evrard, France | Schizophrenia, Electroconvulsive Therapy | 10/23 | 10/23 | | |
| Recruiting | N/A | 60 | Europe | Cerebral neuroinflammation evaluation | University Hospital, Toulouse, Institut National de la Santé Et de la Recherche Médicale, France | Depressive Disorder | 01/24 | 01/24 | | |
| Completed | N/A | 100 | Europe | TCI, BPI, CPAQ-8, SF-MPQ, King's Parkinson's Disease Pain Scale (KPPS), Hospital Anxiety and Depression scale (HAD) questionary, PCS, ORT, Social Support Questionnaire (SSQ6), IPQ-R, WCC-R | University Hospital, Toulouse | Parkinson Disease | 04/24 | 04/24 | | |
| Chauveau, Dominique |
| Recruiting | 3 | 272 | Europe | 56 days of weight-adjusted L-Carnitine treatment, 10 days of intravenous placebo (isotonic saline) | Centre Hospitalier Universitaire de Nīmes | Severe Sepsis, Shock, Septic, Acute Kidney Injury | 05/25 | 05/26 | | |
MASTER-ANCA, NCT03323476: Maintaining or Stopping Immunosuppressive Therapy in Patients with ANCA Vasculitis and End-stage Renal Disease |
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| Recruiting | 3 | 136 | Europe | Discontinuation (or not initiation) of Immunosuppressive Therapy, Maintenance (or initiation) of immunosuppressive treatment: Imurel®, Mabthera®,Cellcept®, Cortancyl® | Centre Hospitalier Departemental Vendee | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, End Stage Renal Disease | 03/31 | 03/31 | | |
NCT03804359: Personalized Medicine for Membranous Nephropathy |
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| Recruiting | 2 | 64 | Europe | Rituximab | Centre Hospitalier Universitaire de Nice | Idiopathic Membranous Nephropathy | 09/23 | 09/23 | | |
GYN-HNF1, NCT04746053: Ovarian Function and Gynecological Profile of Patients Carrying a Pathogenic Variant of the HNF1B Gene |
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| Completed | N/A | 26 | Europe | Pelvic ultrasound, blood sample | University Hospital, Toulouse | Genital Diseases, Female | 10/23 | 10/23 | | |
PREPCOV, NCT04481633: Efficacy of Pre-exposure Treatment With Hydroxy-Chloroquine on the Risk and Severity of COVID-19 Infection |
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| Recruiting | N/A | 800 | Europe | COVID 19 serology, COVID 19 Self-Questionnaire | University Hospital, Toulouse | COVID-19 | 03/22 | 03/22 | | |
| HERMANT, Christophe |
LUNG-RESIST, NCT04222335: Understanding and Overcoming the Early Adaptive Resistance to EGFR Tyrosine-kinase Inhibitors in Lung Cancer Patients |
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| Recruiting | N/A | 80 | Europe | Blood samples | University Hospital, Toulouse, Institut National de la Santé Et de la Recherche Médicale, France, National Cancer Institute, France | Lung Cancer, Nonsmall Cell | 12/28 | 12/28 | | |
| GALITZKY, Monique |
| Recruiting | N/A | 62 | Europe | Overnight polysomnography, blood sample, high-resolution MRI scan, neuropsychological evaluation | University Hospital, Toulouse, Centre de Recherches sur la Cognition Animale (CRCA - UMR5169 CNRS/UPS), Centre de Recherche Cerveau & Cognition (CerCo - UMR5549 CNRS/UPS), Toulouse NeuroImaging Center (ToNIC - UMR 1214 Inserm/UPS), Fondation Plan Alzheimer, IHNPS/FHU HoPeS | Alzheimer Disease, Early Onset | 06/23 | 06/23 | | |
