University of Utah School of Medicine
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 35 Trials 
81 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Paine, Robert
SPIROMICS, NCT01969344: Study of COPD Subgroups and Biomarkers

Active, not recruiting
N/A
2981
US
University of North Carolina, Chapel Hill, National Heart, Lung, and Blood Institute (NHLBI), COPD Foundation, Columbia University, Johns Hopkins University, National Jewish Health, Temple University, University of Alabama at Birmingham, University of California, Los Angeles, University of California, San Francisco, University of Illinois at Chicago, University of Iowa, University of Michigan, University of Utah, Wake Forest University
COPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
12/30
12/30
SOURCE, NCT05033990: SPIROMICS Study of Early COPD Progression

Recruiting
N/A
1000
US
Weill Medical College of Cornell University, National Heart, Lung, and Blood Institute (NHLBI), University of North Carolina, Chapel Hill, Columbia University, Johns Hopkins University, National Jewish Health, University of Alabama at Birmingham, University of California, Los Angeles, University of Illinois at Chicago, University of Iowa, University of Michigan, University of Utah, Wake Forest University Health Sciences, Temple University, University of California, San Francisco, COPD Foundation, Mayo Clinic
COPD, Early-Onset
01/25
04/25
Agarwal, Neeraj
S1216, NCT01809691: , Phase III ADT+TAK-700 vs. ADT+Bicalutamide for Metastatic Prostate Cancer

Active, not recruiting
3
1313
US
TAK-700, Orteronel, Bicalutamide, Casodex
SWOG Cancer Research Network, Millennium Pharmaceuticals, Inc., National Cancer Institute (NCI)
Prostate Cancer
03/22
10/27
CYCLONE 3, NCT05288166: A Study of Abemaciclib (LY2835219) With Abiraterone in Men With Prostate Cancer That Has Spread to Other Parts of the Body and is Expected to Respond to Hormonal Treatment (Metastatic Hormone-Sensitive Prostate Cancer)

Active, not recruiting
3
900
Europe, Canada, Japan, US, RoW
Abemaciclib, LY2835219, Abiraterone, Prednisone or Prednisolone, Placebo for Abemaciclib
Eli Lilly and Company
Prostatic Neoplasms, Neoplasm Metastasis, Urogenital Neoplasms, Physiological Effects of Drugs, Antineoplastic Agents, Antineoplastic Agents, Hormonal, Androgens, Hormones, Hormones, Hormone Substitutes, and Hormone Antagonists, Abiraterone Acetate, Steroid Synthesis Inhibitors, Cytochrome P-450, Enzyme Inhibitors, Prednisone, Prednisolone, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6
02/24
10/27
NCT03421782: Fatigue Interventions in Cancer (Exercise Intervention)

Completed
2
126
US
Cognitive Behavior Therapy, CBT, cognitive therapy, CT, Exercise Intervention
University of Utah
Sedentary Lifestyle, Stage III Prostate Cancer AJCC v7, Stage IV Prostate Cancer AJCC v7
04/22
08/22
PemCab, NCT03534804: Cabozantinib Plus Pembrolizumab as First-Line Therapy for Cisplatin-Ineligible Advanced Urothelial Carcinoma

Completed
2
37
US
Cabozantinib, XL184, Pembrolizumab
University of Utah, Exelixis
Metastatic Urothelial Carcinoma, Bladder Cancer
08/23
04/24
BRCAAway, NCT03012321: Abiraterone/Prednisone, Olaparib, or Abiraterone/Prednisone + Olaparib in Patients With Metastatic Castration-Resistant Prostate Cancer With DNA Repair Defects

Active, not recruiting
2
70
US
Olaparib, Lynparza, Abiraterone Acetate, Prednisone
Northwestern University, AstraZeneca, National Cancer Institute (NCI)
Prostate Cancer Metastatic Castration-Resistant, Abnormal DNA Repair, Metastatic Prostate Carcinoma, Stage IV Prostate Cancer
12/26
01/27
NCT00722527: Molecular Biology of Polycythemia and Thrombocytosis

Recruiting
N/A
200
US
University of Utah, National Heart, Lung, and Blood Institute (NHLBI)
Polycythemia, Thrombocytosis
07/28
07/28
Renshaw, Perry F
NCT03202095: Creatine for Treatment of Depression Associated With Type 2 Diabetes

Withdrawn
4
15
US
Creatine Monohydrate
University of Utah
Major Depressive Disorder
06/24
06/24
NCT02192931: A Randomized Double-Blind Controlled Trial of Creatine in Female Methamphetamine Users

Completed
4
66
US
Creatine monohydrate
Perry Renshaw
Depression, Dual Diagnosis, Drug Addiction
01/23
01/23
NCT06506253: Massage for GAD: Neuroimaging and Clinical Correlates of Response

Recruiting
N/A
46
US
Swedish Massage Therapy, Light Touch Therapy
University of Utah, National Center for Complementary and Integrative Health (NCCIH)
Generalized Anxiety Disorder
08/25
08/25
Cabrera, Jorge L
NCT05476276: EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy

Recruiting
2
122
US
ISA specific
James P. Rathmell, MD, New York University, Icahn School of Medicine at Mount Sinai, National Institute of Neurological Disorders and Stroke (NINDS)
Painful Diabetic Neuropathy
01/25
01/25
EN21-01, NCT05480228: EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA

Recruiting
2
122
US
NRD135SE.1, NRD135s.E1, a small chemical entity for treatment of neuropathic pain, Placebo
James P. Rathmell, MD, New York University, National Institute of Neurological Disorders and Stroke (NINDS), Icahn School of Medicine at Mount Sinai
Painful Diabetic Neuropathy
01/25
01/25
Stehlik, Josef
NCT05420012: The Effect of Vericiguat on Peripheral Vascular Function, Patient Health Status and Inflammation

Completed
4
26
US
Vericiguat, VERQUVO, Placebo, Control group
Josef Stehlik, Merck Sharp & Dohme LLC
Heart Failure, Heart Failure with Reduced Ejection Fraction (HFrEF)
10/24
10/24
NCT06625073: Randomized Trial of SGLT2i in Heart Transplant Recipients

Not yet recruiting
4
200
US
Empagliflozin, Jardiance, Placebo, Control Group
VA Office of Research and Development
Heart Transplant, Cardiovascular Disease, Kidney Disease
08/29
02/30
NCT03644667: Tocilizumab in Cardiac Transplantation

Active, not recruiting
2
385
US
tocilizumab, Actemra®, Placebo, Placebo for tocilizumab, Placebo for Actemra®, Standard of Care Triple IS, calcineurin inhibitor: (tacrolimus (Prograf ®)), anti-proliferative treatment: (mycophenolate mofetil ),, MMF, CellCept®, Myfortic®, enteric-coated mycophenolate sodium, steroids: methylprednisolone/prednisone
National Institute of Allergy and Infectious Diseases (NIAID), PPD
Heart Transplant
04/25
04/25
DETECT, NCT05081739: Donor-Derived Cell-free DNA to DETect REjection in Cardiac Transplantation

Withdrawn
N/A
600
NA
Prospera Transplant Assessment, Endomyocardial biopsy
Natera, Inc.
Heart Transplant Failure and Rejection
01/25
01/26
ACES-EMB, NCT06414603: A Comparative Effectiveness Study in Heart Transplant Patients of Rejection Surveillance With Cell-free DNA Versus Endomyocardial Biopsy

Recruiting
N/A
250
US
The Prospera™ Test
Natera, Inc.
Heart Transplant Failure and Rejection
12/24
12/25
LINK-HF2, NCT04502563: - Remote Monitoring Analytics in Heart Failure

Completed
N/A
208
US
Remote monitoring and predictive analytics, Sham comparator
VA Office of Research and Development, George E. Wahlen Department of Veterans Affairs Medical Center, Michael E. DeBakey VA Medical Center, VA Palo Alto Health Care System, Malcom Randall VA Medical Center, Hunter Holmes McGuire VA Medical Center, VHA Innovation Ecosystem
Heart Failure
08/24
10/24
NCT02670408: Diagnostic and Therapeutic Applications of Microarrays in Heart Transplantation

Recruiting
N/A
900
Europe, Canada, US, RoW
Endomyocardial biopsy
University of Alberta
Cardiac Transplant Disorder
12/25
07/26
NCT04707872: Trifecta-Heart cfDNA-MMDx Study

Recruiting
N/A
300
Europe, Canada, US, RoW
MMDx diagnostic test, Prospera, HLA antibody
University of Alberta, Natera, Inc., One Lambda
Heart Transplant Rejection
12/26
07/27
DEFINE-HT, NCT05309382: Development of Non-invasive Cell-free DNA to Supplant Invasive Biopsy in Heart Transplantation

Completed
N/A
147
US
Prospera
Natera, Inc.
Heart Transplant
10/24
10/24
IICAPTAIN-HF, NCT06526988: Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure

Not yet recruiting
N/A
2200
US
EPIC-HF Patient-facing Tool, PROMPT-HF Clinician-facing Alert
University of Colorado, Denver, Patient-Centered Outcomes Research Institute, Yale University, Northwestern University, University of Utah, Sutter Health
Heart Failure With Reduced Ejection Fraction
09/28
09/28
NCT01099982: Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease

Recruiting
N/A
300
US
University of Utah, Intermountain Health Care, Inc., VA Salt Lake City Health Care System, Hunter Holmes McGuire VA Medical Center
Congestive Heart Failure
01/28
01/28
Supiano, Mark
ENHANCE, NCT05929703: Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders

Recruiting
N/A
3000
US
HELP, FAM-HELP
University of Michigan, Hebrew SeniorLife, MaineHealth, University of Pennsylvania, West Penn Allegheny Health System, UnityPoint Health - Meriter Hospital, University of Utah, MemorialCare Saddleback Medical Center, Brandeis University, Indiana University, Patient-Centered Outcomes Research Institute
Delirium, Neurocognitive Disorders, Mild Cognitive Impairment, Alzheimer Disease, Aging, Family Support, Family Members, Caregiver Burden, Implementation Science, Patient Satisfaction
05/27
08/27
Fluchel, Mark
NCT06450041: NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial

Recruiting
2
62
US
Universal Donor (UD) TGFβi NK Cells, Temozolomide, Irinotecan, Dinutuximab, Unituxin, GM-CSF, Sargramostim
New Approaches to Neuroblastoma Therapy Consortium, Nationwide Children's Hospital, United Therapeutics, Children's Neuroblastoma Cancer Fund
Neuroblastoma
12/28
12/38
NMTT, NCT02679144: Neuroblastoma Maintenance Therapy Trial

Recruiting
2
441
Canada, US
Difluoromethylornithine (DFMO), eflornithine
Giselle Sholler, Beat NB Cancer Foundation, Team Parker for Life
Neuroblastoma
02/28
02/33
NCT05642455: SPEARHEAD-3 Pediatric Study

Recruiting
1/2
20
US
Afamitresgene autoleucel
Adaptimmune
Synovial Sarcoma, Malignant Peripheral Nerve Sheath Tumor (MPNST), Neuroblastoma, Osteosarcoma
10/26
07/38
NCT01587300: Neuroblastoma Biology Study

Recruiting
N/A
1000
Canada, US
New Approaches to Neuroblastoma Therapy Consortium
Neuroblastoma
12/99
12/99
Kondo, Douglas
NCT03265964: Clinical and Imaging Trial of Uridine for Veterans With Suicidal Ideation

Completed
4
75
US
Uridine, Oral Uridine, Placebo, Oral Pill Placebo
VA Office of Research and Development
Suicidal Ideation
06/24
06/24
Reed, Larry
CHALLENGE-MIG, NCT05127486: A Study of Galcanezumab (LY2951742) in Adult Participants With Episodic Migraine

Checkmark Enrollment initiated in combination with Emgality for episodic migraine
Nov 2021 - Nov 2021: Enrollment initiated in combination with Emgality for episodic migraine
Completed
4
580
US
Galcanezumab, LY2951742, Rimegepant, Placebo
Eli Lilly and Company
Migraine, Episodic Migraine
05/23
05/23
NCT06153693: Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension

Active, not recruiting
3
1083
Europe, Canada, US, RoW
Placebo, lorundrostat Dose 1, lorundrostat Dose 2
Mineralys Therapeutics Inc.
Hypertension
12/24
02/25
NCT05968430: Open-Label Extension (OLE) Study to Assess Safety, Efficacy, and Tolerability of Lorundrostat in Subjects with Hypertension

Enrolling by invitation
3
1400
Europe, Canada, US, RoW
lorundrostat, Placebo
Mineralys Therapeutics Inc.
Hypertension
12/25
12/26
SURMOUNT-MMO, NCT05556512: A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

Active, not recruiting
3
15374
Europe, Canada, Japan, US, RoW
Tirzepatide, LY3298176, Placebo
Eli Lilly and Company
Obesity, Overweight
10/27
10/27
NCT05025787: A Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Knee Osteoarthritis Pain.

Completed
2
77
US
CNTX-6970, Placebo
Maurizio Fava, MD
Knee Osteoarthritis
06/24
06/24
NCT05476276: EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy

Recruiting
2
122
US
ISA specific
James P. Rathmell, MD, New York University, Icahn School of Medicine at Mount Sinai, National Institute of Neurological Disorders and Stroke (NINDS)
Painful Diabetic Neuropathy
01/25
01/25
EN21-01, NCT05480228: EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA

Recruiting
2
122
US
NRD135SE.1, NRD135s.E1, a small chemical entity for treatment of neuropathic pain, Placebo
James P. Rathmell, MD, New York University, National Institute of Neurological Disorders and Stroke (NINDS), Icahn School of Medicine at Mount Sinai
Painful Diabetic Neuropathy
01/25
01/25
Gallegos-Orozco, Juan
NATiV3, NCT04849728: A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( )

Recruiting
3
1000
Europe, Canada, US, RoW
IVA337, Lanifibranor, Placebo
Inventiva Pharma
NASH - Nonalcoholic Steatohepatitis
09/25
09/26
NAVIGATE, NCT04365868 / 2019-001983-31: Study Evaluating the Efficacy and Safety of Belapectin for the Prevention of Esophageal Varices in NASH Cirrhosis

Active, not recruiting
2b
357
Europe, Canada, US, RoW
belapectin, GR-MD-02, galactoarabino rhamnogalacturonate, Placebo
Galectin Therapeutics Inc., Galectin Therapeutics Inc
Prevention of Esophageal Varices, NASH - Nonalcoholic Steatohepatitis, Cirrhosis
12/24
12/24
FRESH, NCT05639543 / 2022-001639-10: FXR Effect on Severe Alcohol-Associated Hepatitis () Study

Recruiting
2
50
Europe, US
INT-787, Placebo
Intercept Pharmaceuticals, Intercept Pharmaceuticals, Inc.
Alcohol Associated Hepatitis
12/24
03/25
NCT05239468 / 2022-001241-20: Study of OCA in Combination With BZF Evaluating Efficacy, Safety and Tolerability in Participants With PBC

Active, not recruiting
2
60
US
Bezafibrate 100 mg, Bezafibrate 200 mg, Obeticholic Acid 5 mg, Obeticholic Acid placebo, Bezafibrate Placebo
Intercept Pharmaceuticals, Intercept Pharmaceuticals, Inc.
Primary Biliary Cholangitis
11/24
02/25
VISTAS, NCT04663308 / 2020-003027-41: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

Recruiting
2
200
Europe, Canada, US, RoW
Volixibat, SHP626, Placebo
Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc.
Primary Sclerosing Cholangitis
09/25
12/25
NCT04505436: Study to Evaluate Efficacy, Safety and Tolerability of HM15211 in Subjects

Recruiting
2
240
US, RoW
HM15211, Placebo of HM15211
Hanmi Pharmaceutical Company Limited
NASH - Nonalcoholic Steatohepatitis
05/26
11/26
NCT04884815 / 2020-005266-34: Study of UX701 Gene Transfer for the Treatment of Wilson Disease

Active, not recruiting
1/2
78
Europe, Canada, US
UX701, Placebo
Ultragenyx Pharmaceutical Inc, Ultragenyx Pharmaceutical Inc.
Wilson Disease
08/26
11/31
NCT03838250: Study to Evaluate Hepatic Artery Injection of Autologous Human Bone Marrow-Derived MSCs in Patients With Alcoholic LC

Recruiting
1
10
US
Cellgram™ (Bone marrow-derived MSCs)
Pharmicell Co., Ltd.
Alcoholic Liver Cirrhosis
03/21
06/21
CHANCE, NCT04613921: Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

Recruiting
N/A
3000
Europe, Canada, Japan, US, RoW
Observational Protocol
European Foundation for Study of Chronic Liver Failure
Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
12/25
12/26
McCormick, Zachary
MODEL, NCT05516992: Moderate - Severe Degenerative Disc Disease Evaluation of the Lumbar Spine

Active, not recruiting
3
417
US
SB-01 For Injection, Sham Needle
Spine BioPharma, Inc, MCRA
Lumbar Degenerative Disc Disease
02/25
08/25
Saol 1010-01, NCT05470608: Phase II Study to Assess Safety and Efficacy of SL-1002 for Osteoarthritic Knee Pain

Active, not recruiting
2
132
US
SL-1002, Placebo
Saol Therapeutics Inc
Osteoarthritis, Knee Pain
01/24
01/24
NCT04537026: Sterile Amniotic Fluid Filtrate Epidural Injection.

Recruiting
1/2
112
US
Amniotic Fluid Allograft, Dexamethasone sodium phosphate
University of Utah, Cell Therapy & Regenerative Medicine
Lumbar Spinal Stenosis
01/25
12/25
NCT05121961: Treatment for Sacroiliac Joint Pain Using Platelet-rich Plasma (PRP) Versus Steroid/Anesthetic

Recruiting
N/A
50
US
Sacroiliac intra-articular injection
University of Utah, Radiological Society of North America
Low Back Pain, Sacroiliac Joint Synovitis
06/25
06/25
NCT04246281: The RESET Clinical Trial: SPRINT® Peripheral Nerve Stimulation for the Treatment of Back Pain

Active, not recruiting
N/A
230
US
SPRINT Peripheral Nerve Stimulation (PNS) System, Standard interventional management of low back pain
SPR Therapeutics, Inc., United States Department of Defense
Low Back Pain, Back Pain
03/26
02/27
NCT05660512: Intracept Intraosseous Basivertebral Nerve Ablation

Active, not recruiting
N/A
150
US
Intracept Procedure
University of Utah, Relievant Medsystems
Low Back Pain
10/25
07/26
NCT05491915: The MONARCH Case Series Study: SPRINT® Peripheral Nerve Stimulation for the Treatment of Head Pain

Recruiting
N/A
50
US
SPRINT Peripheral Nerve Stimulation (PNS) System
SPR Therapeutics, Inc.
Cervicogenic Headache, Occipital Neuralgia
08/27
08/27
Laguna, Ignacio Garrido
NCT05228600: YL-13027 in Patients With Advanced Solid Tumors

Recruiting
1
54
US
YL-13027
Shanghai YingLi Pharmaceutical Co. Ltd., Yingli Pharma US, Inc
Solid Tumor
12/22
12/23
NCT06586515: A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

Recruiting
1
530
Europe, Canada, Japan, US
LY3962673, Cetuximab, Gemcitabine, nab-paclitaxel, Oxaliplatin, leucovorin, Irinotecan, 5-fluorouracil
Eli Lilly and Company, Loxo Oncology, Inc.
Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, Colorectal Cancer
03/29
03/29
Gutierrez, Jonathan
NCT05614115: Safety, Tolerability, and Feasibility of Empagliflozin Therapy in Dialysis-dependent ESKD

Recruiting
1
75
US
Empagliflozin, Jardiance®, CL-JAR-100113 02.28.2022, Placebo
University of Utah, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
End-stage Kidney Disease, Kidney Disease, Chronic, Dialysis, Diabetic, Non-diabetic, Kidney Dysfunction, Kidney Failure, Hemodialysis
03/25
03/25
Revere, Cathy
NCT05476276: EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy

Recruiting
2
122
US
ISA specific
James P. Rathmell, MD, New York University, Icahn School of Medicine at Mount Sinai, National Institute of Neurological Disorders and Stroke (NINDS)
Painful Diabetic Neuropathy
01/25
01/25
EN21-01, NCT05480228: EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA

Recruiting
2
122
US
NRD135SE.1, NRD135s.E1, a small chemical entity for treatment of neuropathic pain, Placebo
James P. Rathmell, MD, New York University, National Institute of Neurological Disorders and Stroke (NINDS), Icahn School of Medicine at Mount Sinai
Painful Diabetic Neuropathy
01/25
01/25
DLss, NCT06030297: Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.

Recruiting
N/A
301
US
Diode Laser fiber type Selective Stimulator, DLss, ZTlido 1.8 % Topical System, PeriCam PSI NR, speckle imager, Medoc Quantitative Sensory Testing, QST, Inactive Topical System, placebo patch
University of Utah, Stanford University, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS)
Peripheral Neuropathy
08/25
08/25
Wever-Pinzon, Omar
DEFINE-HT, NCT05309382: Development of Non-invasive Cell-free DNA to Supplant Invasive Biopsy in Heart Transplantation

Completed
N/A
147
US
Prospera
Natera, Inc.
Heart Transplant
10/24
10/24
Moldt, Sarah
HOPE-3, NCT05126758: A Study of Deramiocel (CAP-1002) in Ambulatory and Non-Ambulatory Patients With Duchenne Muscular Dystrophy

Active, not recruiting
3
104
US
Deramiocel (CAP-1002), Cardiosphere-Derived Cells (CDCs), Placebo
Capricor Inc.
Muscular Dystrophies, Muscular Dystrophy, Duchenne, Muscular Disorders, Atrophic, Muscular Diseases, Neuromuscular Diseases, Genetic Diseases, X-Linked, Genetic Diseases, Inborn, Nervous System Diseases
12/25
12/27
MOVE FSHD, NCT04635891: Motor Outcomes to Validate Evaluations in FSHD

Recruiting
N/A
450
Europe, Canada, US
University of Kansas Medical Center, FSHD Society, Inc., Friends Research Institute, Inc., University of Rochester, University of Nevada, Reno, FSHD Canada, Avidity Biosciences, Inc., AMRA Medical, Seattle Children's Hospital, Dyne Therapeutics, Hoffmann-La Roche
FSHD
12/26
01/27
NCT04174157: Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)

Recruiting
N/A
700
Europe, Japan, US, RoW
Prospective observational registry, Zolgensma
Novartis Pharmaceuticals, United BioSource, LLC
Spinal Muscular Atrophy (SMA)
06/38
06/38
Stumbris, Ronald
NCT06153693: Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension

Active, not recruiting
3
1083
Europe, Canada, US, RoW
Placebo, lorundrostat Dose 1, lorundrostat Dose 2
Mineralys Therapeutics Inc.
Hypertension
12/24
02/25
NCT05968430: Open-Label Extension (OLE) Study to Assess Safety, Efficacy, and Tolerability of Lorundrostat in Subjects with Hypertension

Enrolling by invitation
3
1400
Europe, Canada, US, RoW
lorundrostat, Placebo
Mineralys Therapeutics Inc.
Hypertension
12/25
12/26
SURMOUNT-MMO, NCT05556512: A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity

Active, not recruiting
3
15374
Europe, Canada, Japan, US, RoW
Tirzepatide, LY3298176, Placebo
Eli Lilly and Company
Obesity, Overweight
10/27
10/27
NCT05476276: EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy

Recruiting
2
122
US
ISA specific
James P. Rathmell, MD, New York University, Icahn School of Medicine at Mount Sinai, National Institute of Neurological Disorders and Stroke (NINDS)
Painful Diabetic Neuropathy
01/25
01/25
EN21-01, NCT05480228: EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA

Recruiting
2
122
US
NRD135SE.1, NRD135s.E1, a small chemical entity for treatment of neuropathic pain, Placebo
James P. Rathmell, MD, New York University, National Institute of Neurological Disorders and Stroke (NINDS), Icahn School of Medicine at Mount Sinai
Painful Diabetic Neuropathy
01/25
01/25
NCT06151288: Safety, Tolerability, and Immunogenicity Study of a 31-Valent Pneumococcal Conjugate Vaccine (VAX-31) in Adults

Completed
1/2
1015
US
31 valent pneumococcal conjugate vaccine, 20 valent pneumococcal conjugate vaccine, PCV20, Prevnar 20™
Vaxcyte, Inc.
Pneumococcal Vaccines
07/24
07/24
Yoon, Sarang
NCT05514002: Comparison of Recombinant Influenza Vaccine Versus Standard Egg-Based Inactivated Influenza Vaccine in Adults 18-64 Years

Terminated
4
3988
US
Fluzone Quadrivalent, Flublok Quadrivalent
Fatimah Dawood, Westat, University of Arizona, Florida A&M University, Center for Asian Health Equity, Baylor College of Medicine, CVS Health Clinical Trial Services LLC, University of Utah
Influenza, Human
12/23
12/23
BEEHIVE, NCT06065176: The Efficacy of the 2023-2024 Updated COVID-19 Vaccines Against COVID-19 Infection

Recruiting
4
1500
US
Novavax COVID-19 vaccine (2023-2024 formula XBB containing), Pfizer COVID-19 mRNA vaccine (2023-2024 formula XBB containing)
Sarang K. Yoon, DO, MOH, Westat, Novavax
COVID-19, Vaccine-Preventable Diseases, SARS CoV 2 Infection, Upper Respiratory Tract Infection, Upper Respiratory Disease
07/24
07/24
SHIELD, NCT06633835: Impact of Reactogenicity of the 2024-2025 COVID-19 Vaccines on Health Care Workers and First Responders in the United States

Active, not recruiting
4
660
US
protein subunit: Novavax COVID-19 vaccine, 2024-25 COVID-19 vaccination, Pfizer mRNA COVID-19 vaccine, 2024-2025 formula
Novavax, University of Utah
COVID-19, Vaccine-Preventable Diseases, SARS CoV 2 Infection
12/24
08/25
Bonkowsky, Joshua
NCT05757141: An Open-Label Exploratory Study of Fosigotifator in Participants With Vanishing White Matter Disease

Recruiting
1/2
50
Europe, US
Fosigotifator, ABBV-CLS-7262
AbbVie, Calico Life Sciences LLC
Vanishing White Matter Disease
11/27
11/29
NCT03047369: The Myelin Disorders Biorepository Project

Recruiting
N/A
12000
US
Children's Hospital of Philadelphia, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS), National Center for Advancing Translational Sciences (NCATS), Biogen, Eli Lilly and Company, Myrtelle Inc., Orchard Therapeutics Ltd., Passage Bio, Inc., Synaptix Biotherapeutics Ltd., Takeda, Boehringer Ingelheim, Ionis Pharmaceuticals, Inc., Sanofi Winthrop Industrie, Sana Biotechnology, Yaya Foundation for 4H Leukodystrophy, University of Pennsylvania, United MSD Foundation, Foundation to Fight H-ABC, Calliope Joy Foundation, Don't Forget Me Foundation
Leukodystrophy, White Matter Disease, Leukoencephalopathies, 4H Syndrome, Adrenoleukodystrophy, AMN, ALD, ALD Gene Mutation, ALD (Adrenoleukodystrophy), X-linked Adrenoleukodystrophy, X-ALD, Adrenomyeloneuropathy, Aicardi Goutieres Syndrome, AGS, Alexander Disease, Alexanders Leukodystrophy, AxD, ADLD, Canavan Disease, CTX, Cerebrotendinous Xanthomatoses, Krabbe Disease, GALC Deficiency, Globoid Leukodystrophy, TUBB4A-Related Leukodystrophy, H-ABC - Hypomyelination, Atrophy of Basal Ganglia and Cerebellum, HBSL, HBSL - Hypomyelination, Brain Stem, Spinal Cord, Leg Spasticity, LBSL, Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder), Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation, ALSP, CSF1R Gene Mutation, HCC - Hypomyelination and Congenital Cataract, MLC1, Megalencephalic Leukoencephalopathy With Subcortical Cysts, MLD, Metachromatic Leukodystrophy, PMD, Pelizaeus-Merzbacher Disease, PLP1 Null Syndrome, PLP1 Gene Duplication | Blood or Tissue | Mutations, Pelizaeus Merzbacher Like Disease, Peroxisomal Biogenesis Disorder, Zellweger Syndrome, Refsum Disease, Salla Disease, Sialic Storage Disease, Sjögren, Sjogren-Larsson Syndrome, Van Der Knapp Disease, Vanishing White Matter Disease, Charcot-Marie-Tooth, CMT, Mct8 (Slc16A2)-Specific Thyroid Hormone Cell Transporter Deficiency, Allan-Herndon-Dudley Syndrome, Cadasil, Cockayne Syndrome, Multiple Sulfatase Deficiency, Gangliosidoses, GM2 Gangliosidosis, BPAN, Labrune Syndrome, LCC, Mucopolysaccharidoses, TBCK-Related Intellectual Disability Syndrome
12/30
12/30
Skoien, Richard
NATiV3, NCT04849728: A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( )

Recruiting
3
1000
Europe, Canada, US, RoW
IVA337, Lanifibranor, Placebo
Inventiva Pharma
NASH - Nonalcoholic Steatohepatitis
09/25
09/26
Mueller, Bridgett
NCT05476276: EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy

Recruiting
2
122
US
ISA specific
James P. Rathmell, MD, New York University, Icahn School of Medicine at Mount Sinai, National Institute of Neurological Disorders and Stroke (NINDS)
Painful Diabetic Neuropathy
01/25
01/25
EN21-01, NCT05480228: EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA

Recruiting
2
122
US
NRD135SE.1, NRD135s.E1, a small chemical entity for treatment of neuropathic pain, Placebo
James P. Rathmell, MD, New York University, National Institute of Neurological Disorders and Stroke (NINDS), Icahn School of Medicine at Mount Sinai
Painful Diabetic Neuropathy
01/25
01/25
Mardmomen, Niayesh
BEST, NCT05396014: The Trial: Biomarkers for Evaluating Spine Treatments

Completed
4
1014
US
Enhanced Self-Care (ESC), Acceptance and Commitment Therapy (ACT), Evidence-Based Exercise and Manual Therapy (EBEM), Duloxetine, Cymbalta
University of North Carolina, Chapel Hill, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Chronic Low-back Pain
07/24
10/24
NCT05476276: EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy

Recruiting
2
122
US
ISA specific
James P. Rathmell, MD, New York University, Icahn School of Medicine at Mount Sinai, National Institute of Neurological Disorders and Stroke (NINDS)
Painful Diabetic Neuropathy
01/25
01/25
EN21-01, NCT05480228: EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA

Recruiting
2
122
US
NRD135SE.1, NRD135s.E1, a small chemical entity for treatment of neuropathic pain, Placebo
James P. Rathmell, MD, New York University, National Institute of Neurological Disorders and Stroke (NINDS), Icahn School of Medicine at Mount Sinai
Painful Diabetic Neuropathy
01/25
01/25
McKell, Jacob
BEEHIVE, NCT06065176: The Efficacy of the 2023-2024 Updated COVID-19 Vaccines Against COVID-19 Infection

Recruiting
4
1500
US
Novavax COVID-19 vaccine (2023-2024 formula XBB containing), Pfizer COVID-19 mRNA vaccine (2023-2024 formula XBB containing)
Sarang K. Yoon, DO, MOH, Westat, Novavax
COVID-19, Vaccine-Preventable Diseases, SARS CoV 2 Infection, Upper Respiratory Tract Infection, Upper Respiratory Disease
07/24
07/24

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