| Khanna, Anna |
CREST-H, NCT03121209: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics |
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| Active, not recruiting | 3 | 385 | Canada, US | Revascularization, Intensive Medical Management (IMM) alone | Columbia University, National Institute of Neurological Disorders and Stroke (NINDS), Mayo Clinic, University of Alabama at Birmingham, University of Maryland, University of California, Los Angeles | Internal Carotid Artery Stenosis, Cognitive Impairment | 01/27 | 07/27 | | |
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis |
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| Recruiting | 3 | 1683 | US | Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management | University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca | Intracranial Arteriosclerosis, Stroke | 05/28 | 05/28 | | |
| Recruiting | 3 | 860 | Europe, Canada, Japan, US | Recombinant Activated Factor VII (rFVIIa), NovoSeven, NiaStase, Placebo | Joseph Broderick, MD, Novo Nordisk A/S, National Institute of Neurological Disorders and Stroke (NINDS) | Intracerebral Hemorrhage | 01/28 | 01/28 | | |
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial |
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| Active, not recruiting | N/A | 2486 | Europe, Canada, US, RoW | Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS | Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS) | Carotid Stenosis | 02/26 | 02/26 | | |
| Recruiting | N/A | 3062 | US | CPAP | University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), FusionHealth LLC, Medical University of South Carolina, University of Cincinnati | Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial | 11/26 | 11/26 | | |
| Wynn, Tung |
| Withdrawn | 3 | 85 | US | SPK-8011, AAV-Spark200-BDD-hFVIII, Dirloctocogene samoparvovec | Spark Therapeutics, Inc. | Hemophilia A | 05/27 | 09/35 | | |
NCT02932618 / 2016-001477-33: A Study of Recombinant Von Willebrand Factor (rVWF) With or Without ADVATE in Children With Severe Von Willebrand Disease (VWD) |
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| Recruiting | 3 | 34 | Europe, US, RoW | von Willebrand factor (Recombinant), VONVENDI, rVWF, BAX111, BAX 111, Antihemophilic Factor (Recombinant), ADVATE, Recombinant Factor VIII, rFVIII | Baxalta now part of Shire, Takeda Development Center Americas, Inc. | Von Willebrand Disease | 01/25 | 01/25 | | |
| Active, not recruiting | 1/2 | 21 | US | Nivolumab, Opdivo®, Azacitidine, Vidaza®, Post Treatment Surgery, Standard of Care, Resection of disease | H. Lee Moffitt Cancer Center and Research Institute, Bristol-Myers Squibb | Osteosarcoma, Osteosarcoma in Children, Osteosarcoma Recurrent, Sarcoma | 12/24 | 12/25 | | |
| Active, not recruiting | N/A | 108 | US | | American Thrombosis and Hemostasis Network, Takeda | Von Willebrand Diseases | 12/24 | 01/25 | | |
| Recruiting | N/A | 520 | US | NOURISH-T+, Brief NOURISH-T+ | University of South Florida, National Cancer Institute (NCI) | Obesity, Childhood, Cancer, Survivorship | 10/25 | 11/25 | | |
NCT04158934: A Long-term Study of ADYNOVI/ADYNOVATE in Participants With Haemophilia A |
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| Active, not recruiting | N/A | 207 | Europe, US, RoW | ADYNOVI/ADYNOVATE, Antihaemophilic Factor [Recombinant] PEGylated rurioctocog alfa pegol, TAK-660, BAX 855 | Baxalta now part of Shire | Hemophilia A | 02/30 | 02/30 | | |
| Recruiting | N/A | 3000 | US | | American Thrombosis and Hemostasis Network, Pfizer, Hemophilia of Georgia, Inc., Genentech, Inc., Hemab Therapeutics, CSL Behring, Sanofi, Novo Nordisk A/S | Hematologic Disorder, Bleeding Disorder, Connective Tissue Disorder, Hemophilia, Thrombosis, Von Willebrand Diseases, Thrombophilia, Rare Bleeding Disorder, Platelet Disorder, Factor IX Deficiency, Factor VIII Deficiency, Thalassemia, Sickle Cell Disease | 06/35 | 12/35 | | |
| Fort, John |
| Active, not recruiting | 2 | 118 | Europe, Canada, US, RoW | Crizanlizumab, SEG101 | Novartis Pharmaceuticals | Sickle Cell Disease (SCD) | 01/25 | 01/25 | | |
| Active, not recruiting | 1/2 | 21 | US | Nivolumab, Opdivo®, Azacitidine, Vidaza®, Post Treatment Surgery, Standard of Care, Resection of disease | H. Lee Moffitt Cancer Center and Research Institute, Bristol-Myers Squibb | Osteosarcoma, Osteosarcoma in Children, Osteosarcoma Recurrent, Sarcoma | 12/24 | 12/25 | | |
| Moldawer, Lyle L |
NCT02554630: Novel Mechanisms and Approaches to Treat Neonatal Sepsis |
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| Completed | N/A | 142 | US | Adjuvant, Lippopolysaccaride, Specific toll-like receptor 4 agonist, Non-specific toll-like receptor 4 agonist, Blood Collection | University of Florida, National Institute of General Medical Sciences (NIGMS), Surgical Infection Society | Complication of Prematurity, Immunologic Deficiency Syndromes | 10/22 | 10/22 | | |
NavigateAKI, NCT02114138: Network Analysis of Urinary Molecular Signature Complements Clinical Data to Predict Postoperative Acute Kidney Injury |
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| Active, not recruiting | N/A | 240 | US | pathogenesis of perioperative acute kidney injury, urine collection | University of Florida, Heermann Anesthesia Foundation | Acute Kidney Injury | 06/25 | 12/25 | | |
NCT05110937: Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis |
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| Recruiting | N/A | 450 | US | Blood sampling | University of Florida, National Institute of General Medical Sciences (NIGMS) | Sepsis, Trauma Injury | 07/25 | 04/26 | | |
| Ahmed, Mustafa |
AGENT IDE, NCT06492174: A Clinical Trial to Assess the Agent Paclitaxel Coated PTCA Balloon Catheter for the Treatment of Subjects With In-Stent Restenosis (ISR) - Long Lesion Cohort |
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| Active, not recruiting | 3 | 20 | US | AGENT DCB 40 mm | Boston Scientific Corporation | In-Stent Restenosis | 12/25 | 12/27 | | |
NCT04811261: u-STOP LVAD Bleed: Utilization of Umbilical Cord Lining Stem Cells (ULSCs) To Prevent Left Ventricular Assist Device (LVAD) Associated Angiodysplastic Bleeding |
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| Completed | 1 | 9 | US | Intravenous Infusion of UCLSCs | University of Florida | Angiodysplastic Bleeding | 07/23 | 07/23 | | |
| Active, not recruiting | N/A | 572 | Europe, Canada, US | TriClipTM Device | Abbott Medical Devices | Tricuspid Regurgitation | 11/22 | 04/29 | | |
COMPETENCE, NCT01187368: Prospective Multi-Center Randomized Study for Evaluating the EVAHEART®2 Left Ventricular Assist System |
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| Suspended | N/A | 399 | US | EVAHEART Left Ventricular Assist System (LVAS), EVA2, HeartMate 3, HM3 | Evaheart, Inc. | Heart Failure | 07/27 | 07/28 | | |
| Recruiting | N/A | 200 | Europe, Canada, US | AVP III | Abbott Medical Devices | Paravalvular Aortic Regurgitation | 07/25 | 06/26 | | |
NCT06132997: Medical Thoracoscopy in Treatment Outcomes of Empyema Management |
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| Not yet recruiting | N/A | 100 | NA | Thoracoscopy procedure, Chest tube thoracostomy | Hend Mohamed Sayed Mohamed | Empyema | 12/24 | 03/25 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Completed | N/A | 1127 | Europe, Canada, US, RoW | Evolut™ PRO and Evolut™ PRO+ System (Evolut™ FX System for the addendum) | Medtronic Cardiovascular | Symptomatic Aortic Stenosis | 12/23 | 11/24 | | |
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN |
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| Recruiting | N/A | 1400 | Europe, US, RoW | Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation | Medtronic Vascular | Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus | 11/26 | 11/29 | | |
NCT03735667: ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement |
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| Active, not recruiting | N/A | 1948 | Canada, US | ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL | Boston Scientific Corporation | Aortic Stenosis | 06/24 | 09/34 | | |
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation |
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| Recruiting | N/A | 958 | Canada, US | Tendyne Mitral Valve System, MitraClip System | Abbott Medical Devices | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease | 05/24 | 06/28 | | |
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study |
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| Recruiting | N/A | 400 | Europe, US, RoW | AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy | Ancora Heart, Inc. | Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy | 12/26 | 12/30 | | |
| Recruiting | N/A | 15 | US | Intrepid™ TTVR System | Medtronic Cardiovascular | Tricuspid Regurgitation | 07/25 | 07/31 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
DVT, NCT06729021: Predictive Value of Modified Caprini Score and D-Dimer in Managing Lower Limb Venous Thrombosis in Cardiothoracic Patients |
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| Recruiting | N/A | 112 | RoW | GCS, LMWH | Al-Nahrain University | DVT - Deep Vein Thrombosis | 04/25 | 05/25 | | |
| Not yet recruiting | N/A | 188 | RoW | | Al-Nahrain University | Chest Trauma | 04/25 | 04/25 | | |
| Recruiting | N/A | 650 | Europe, Canada, Japan, US, RoW | Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT) | Medtronic Cardiovascular | Moderate Aortic Valve Stenosis | 02/26 | 12/34 | | |
PROTECT IV, NCT04763200: Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function |
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| Recruiting | N/A | 1252 | Europe, Canada, US | Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump | Abiomed Inc. | Left Ventricular Dysfunction, Coronary Artery Disease | 03/26 | 10/27 | | |
| Recruiting | N/A | 500 | Europe, Canada, US | MitraClip™ device implantation, Mitral Valve Repair Surgery | Abbott Medical Devices | Mitral Valve Regurgitation | 04/26 | 04/34 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Recruiting | N/A | 3784 | Europe, US, RoW | Coronary and peripheral stents, Pacing catheters, Vascular plugs, Measurement and imaging (FFR and OCT), Peripheral dilatation catheters, Coronary dilatation catheters, Coronary and peripheral guidewires, Vessel closure/compression devices, Vascular access introducers | Abbott Medical Devices | Acute Myocardial Infarction, Restenoses, Coronary, Coronary Artery Lesions, Venous Embolism, Arterial Embolism | 11/30 | 11/31 | | |
| Toskich, Beau |
| Recruiting | 2 | 100 | Europe, US | TheraSphere Y-90 glass microsphere therapy, Durvalumab (Imfinzi) immunotherapy, Tremelimumab immunotherapy | Boston Scientific Corporation, Biocompatibles UK Ltd | Hepatocellular Carcinoma | 06/27 | 06/27 | | |
NCT04107766: NOLA (NeuWave Observational Liver Ablation) Registry |
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| Recruiting | N/A | 1500 | Europe, US, RoW | Microwave Ablation | Ethicon, Inc. | Cancer of the Liver, Liver Cancer, Neoplasms, Liver | 12/30 | 12/30 | | |
| Geocadin, Romer |
| Recruiting | N/A | 1800 | US | Therapeutic Hypothermia | University of Michigan, Johns Hopkins University, Medical University of South Carolina, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS) | Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain | 07/28 | 08/28 | | |
| Lanz, Jennifer |
NCT02577731: Hematopoietic Stem Cell Dysfunction in the Elderly After Severe Injury |
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| Recruiting | N/A | 400 | US | Bone marrow collection, Blood collection, Clinical data collection | University of Florida, National Institute of General Medical Sciences (NIGMS) | Trauma Injury | 12/24 | 12/25 | | |
NCT06606119: The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma |
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| Recruiting | N/A | 275 | US | Data and tissue collection | University of Florida, National Institutes of Health (NIH), National Institute of General Medical Sciences (NIGMS) | Trauma Injury, Trauma, Critical Illness, Microbiome, Chronic Anemia, Acute Blood Loss Anemia | 10/27 | 10/28 | | |
NCT05357170: Gut Microbiome Dysfunction in Sepsis and Trauma Survivors |
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| Recruiting | N/A | 468 | US | Human feces collection, Blood sampling | University of Florida, National Institute of General Medical Sciences (NIGMS) | Sepsis, Trauma Injury | 05/25 | 05/26 | | |
NCT05110937: Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis |
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| Recruiting | N/A | 450 | US | Blood sampling | University of Florida, National Institute of General Medical Sciences (NIGMS) | Sepsis, Trauma Injury | 07/25 | 04/26 | | |
NCT05616130: Pathological Myeloid Activation After Sepsis and Trauma |
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| Recruiting | N/A | 255 | US | Data Collection, Bone marrow collection and blood collection, Serial interviews to complete surveys and questionnaires, Telephone follow up call, Telephone interview | University of Florida, National Institute of General Medical Sciences (NIGMS) | Trauma Injury, Sepsis, Immunosuppression, Chronic Critical Illness | 09/27 | 09/28 | | |
| Brakenridge, Scott |
NCT02711709: Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS): A New Horizon for Surgical Critical Care and Induced Frailty |
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| Active, not recruiting | N/A | 53 | US | Frailty Measurements, Modified Minnesota Leisure Time Activities, Computed tomography morphometrics, Mobility Monitors | University of Florida, National Institute on Aging (NIA), National Institutes of Health (NIH) | Sepsis | 02/20 | 12/24 | | |
| Efron, Philip |
NCT02711709: Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS): A New Horizon for Surgical Critical Care and Induced Frailty |
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| Active, not recruiting | N/A | 53 | US | Frailty Measurements, Modified Minnesota Leisure Time Activities, Computed tomography morphometrics, Mobility Monitors | University of Florida, National Institute on Aging (NIA), National Institutes of Health (NIH) | Sepsis | 02/20 | 12/24 | | |
NCT02276417: PICS: Subtitle Cardiac Dysfunction in Older Sepsis Survivors |
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| Active, not recruiting | N/A | 668 | US | Blood collection, Urine collection, Bioimpedance Analysis, BIA, Cognitive Function Tests, Quality-of-life Questionnaires, Physical Function Tests, Blood Collection | University of Florida, National Institute of General Medical Sciences (NIGMS), American Heart Association | Sepsis | 07/22 | 07/25 | | |
NCT02577731: Hematopoietic Stem Cell Dysfunction in the Elderly After Severe Injury |
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| Recruiting | N/A | 400 | US | Bone marrow collection, Blood collection, Clinical data collection | University of Florida, National Institute of General Medical Sciences (NIGMS) | Trauma Injury | 12/24 | 12/25 | | |
NCT05626699: Evaluation of Clinical Tool to Improve Adherence to Ventilator Management |
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| Not yet recruiting | N/A | 50 | NA | RT Assistant | Convergent Engineering, Inc., University of Florida, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) | Respiratory Therapy | 03/24 | 03/24 | | |
NCT06576570: Evaluation and Modification of Surgeon Ergonomics in the Operation Room Using Artificial Intelligence Analytics |
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| Enrolling by invitation | N/A | 30 | US | Education presentation of surgical ergonomics, Summary of Ergonomic Measurement System | University of Florida | Work Related Upper Limb Disorder, Musculoskeletal Pain | 10/25 | 12/26 | | |
NCT05357170: Gut Microbiome Dysfunction in Sepsis and Trauma Survivors |
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| Recruiting | N/A | 468 | US | Human feces collection, Blood sampling | University of Florida, National Institute of General Medical Sciences (NIGMS) | Sepsis, Trauma Injury | 05/25 | 05/26 | | |
NCT05110937: Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis |
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| Recruiting | N/A | 450 | US | Blood sampling | University of Florida, National Institute of General Medical Sciences (NIGMS) | Sepsis, Trauma Injury | 07/25 | 04/26 | | |
NCT05616130: Pathological Myeloid Activation After Sepsis and Trauma |
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| Recruiting | N/A | 255 | US | Data Collection, Bone marrow collection and blood collection, Serial interviews to complete surveys and questionnaires, Telephone follow up call, Telephone interview | University of Florida, National Institute of General Medical Sciences (NIGMS) | Trauma Injury, Sepsis, Immunosuppression, Chronic Critical Illness | 09/27 | 09/28 | | |
| Castillo, Paul |
| Recruiting | N/A | 200 | US | Blood draw | Emory University, National Heart, Lung, and Blood Institute (NHLBI) | Anemia, Sickle Cell | 07/23 | 07/23 | | |
| Carson, Joshua S |
NCT04040660: Use of NexoBrid for Treatment of Acute Deep Partial and Full Thickness Burn Injuries |
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| Approved for marketing | N/A | | US | NexoBrid | MediWound Ltd | Thermal Burn | | | | |
| Recruiting | N/A | 240 | US | DeepView SnapShot Portable (DV-SSP) | SpectralMD | Burns, Wound Heal, Wounds and Injuries | 03/25 | 04/25 | | |
| Bihorac, Azra |
| Active, not recruiting | N/A | 130 | US | Confusion Assessment Method, Accelerometer, Commercially available camera, imaging, Internet Pod (iPod), Sound detection, Cortisol Swab | University of Florida, U.S. National Science Foundation, National Institute for Biomedical Imaging and Bioengineering (NIBIB), National Institute of Neurological Disorders and Stroke (NINDS) | Delirium, Confusion | 03/20 | 05/25 | | |
NCT03905668: Fundamental Intelligent Building Blocks of the Intensive Care Unit (ICU) of the Future: Intelligent ICU of the Future |
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| Active, not recruiting | N/A | 71 | US | Video Monitoring, Accelerometer Monitoring, Electromyographic Monitoring, EMG monitoring, Noise Level Monitoring, Light Level Monitoring | University of Florida, National Institute for Biomedical Imaging and Bioengineering (NIBIB), U.S. National Science Foundation, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS) | Pain, Delirium | 01/22 | 07/25 | | |
NCT02316951: Monitoring Postoperative Pain and Recovery Following Orthopedic Surgery |
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| Terminated | N/A | 6 | US | single-arm study group | University of Florida | Pain, Postoperative | 08/22 | 08/22 | | |
| Enrolling by invitation | N/A | 625 | US | Level A, Level B, Passive Alert | University of Pittsburgh, University of Florida, University of Pittsburgh Medical Center, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Acute Kidney Injury | 01/26 | 04/26 | | |
| Recruiting | N/A | 400 | US | Video Monitoring, Accelerometer Monitoring, Noise Level Monitoring, Light Level Monitoring, Air Quality Monitoring, EKG Monitoring, Vitals Monitoring, Biosample Collection, Delirium Motor Subtyping Scale 4 (DMSS-4) | University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), National Institute for Biomedical Imaging and Bioengineering (NIBIB) | Critical Illness, Pain, Delirium, Confusion | 12/24 | 12/24 | | |
| Active, not recruiting | N/A | 100 | US | Technology based guided meditation and relaxation | University of Florida | Delirium | 12/24 | 12/24 | | |
NavigateAKI, NCT02114138: Network Analysis of Urinary Molecular Signature Complements Clinical Data to Predict Postoperative Acute Kidney Injury |
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| Active, not recruiting | N/A | 240 | US | pathogenesis of perioperative acute kidney injury, urine collection | University of Florida, Heermann Anesthesia Foundation | Acute Kidney Injury | 06/25 | 12/25 | | |
| Active, not recruiting | N/A | 200 | US | Risk estimation | University of Florida, National Institute of General Medical Sciences (NIGMS) | Postoperative Complications | 11/25 | 11/25 | | |
| Ghiaseddin, Ashley |
EF-41, NCT06556563: /KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma |
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| Recruiting | 3 | 741 | Japan, US | Optune® device, TTFields, Temozolomide, Pembrolizumab, Placebo | NovoCure GmbH, Merck Sharp & Dohme LLC | Glioblastoma | 04/29 | 04/29 | | |
NCT00887146 / 2008-007295-14: Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma |
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| Active, not recruiting | 3 | 305 | Europe, Canada, US | concomitant temozolomide (TMZ), radiotherapy, procarbazine, adjuvant temozolomide (TMZ), CCNU, vincristine | Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI), European Organisation for Research and Treatment Center (EORTC), Canadian Cancer Trials Group | Brain and Central Nervous System Tumors | 10/25 | 10/25 | | |
2-THE-TOP, NCT03405792: Study Testing The Safety and Efficacy of Adjuvant Temozolomide Plus TTFields (Optune®) Plus Pembrolizumab in Patients With Newly Diagnosed Glioblastoma |
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| Active, not recruiting | 2 | 40 | US | Temozolomide (TMZ), Optune System, NovoTTF Therapy, Pembrolizumab, Keytruda | University of Florida, NovoCure Ltd. | Glioblastoma, Glioblastoma, WHO Grade IV | 11/22 | 09/25 | | |
OPTIMUS PRIME, NCT06558214: Safety and Feasibility of OPTune GIO® Integrated With MRI-gUided Laser Ablation Surgery and Pembrolizumab for Recurrent GlIoblastoMa, A randomizEd Trial |
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| Recruiting | 2 | 20 | US | Pembrolizumab, Keytruda, Optune GIO®, TTFields, NeuroBlate®, MLA, LITT | University of Florida | Recurrent Glioblastoma | 10/29 | 10/29 | | |
PNOC020, NCT04573140: A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM) |
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| Active, not recruiting | 1/2 | 52 | US | Autologous total tumor mRNA and pp65 full length (fl) lysosomal associated membrane protein (LAMP) mRNA loaded DOTAP liposome vaccine administered intravenously (RNA loaded lipid particles, RNA-LPs) | University of Florida, Pacific Pediatric Neuro-Oncology Consortium, University of California, San Francisco, CureSearch, Team Jack Foundation, Florida Department of Health, Food and Drug Administration (FDA) | Adult Glioblastoma, High Grade Glioma, WHO Grade III or IV Malignant Glioma | 07/29 | 07/30 | | |
RENEW, NCT04963413: Feasibility of CMV RNA-Pulsed Dendritic Cells Vaccines for the Treatment of Newly Diagnosed Glioblastoma Patients. |
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| Terminated | 1 | 6 | US | Autologous DCs derived from PBMC loaded with RNA encoding the human CMV matrix protein pp65-flLAMP plus GM-CSF | University of Florida, Immunomic Therapeutics, Inc. | Glioblastoma | 09/23 | 09/23 | | |
ADAGiO, NCT06254326: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients |
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| Active, not recruiting | 1 | 12 | US | TTRNA-DC vaccines with GM-CSF, Autologous Hematopoietic Stem cells (HSCs), TTRNA-xALT, Td vaccine | University of Florida, Oligo Nation, Inc | Recurrent Oligodendroglioma, Progressive Oligodendroglioma | 12/27 | 06/28 | | |
NCT06389591: RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM) |
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| Active, not recruiting | 1 | 24 | US | pp65 RNA loaded lipid particles, pp65 RNA-LPs (Drug Product 1 or DP1), RNA loaded lipid particles, RNA-LPs (Drug Product 2 or DP2) | University of Florida, National Cancer Institute (NCI) | Recurrent Glioblastoma | 12/27 | 12/28 | | |
IMPACT, NCT05353530: Phase I Study of IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma |
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| Recruiting | 1 | 18 | US | Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells, 8R-70CAR T cells | University of Florida, United States Department of Defense, AM Rosen Foundation | Glioblastoma Multiforme, Glioblastoma | 12/27 | 12/42 | | |
| Sangha, Navdeep |
| Completed | 3 | 514 | US | Argatroban, Eptifibatide, Placebo | Washington University School of Medicine, National Institute of Neurological Disorders and Stroke (NINDS) | Acute Ischemic Stroke | 12/23 | 10/24 | | |
CREST-H, NCT03121209: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics |
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| Active, not recruiting | 3 | 385 | Canada, US | Revascularization, Intensive Medical Management (IMM) alone | Columbia University, National Institute of Neurological Disorders and Stroke (NINDS), Mayo Clinic, University of Alabama at Birmingham, University of Maryland, University of California, Los Angeles | Internal Carotid Artery Stenosis, Cognitive Impairment | 01/27 | 07/27 | | |
| Recruiting | 3 | 860 | Europe, Canada, Japan, US | Recombinant Activated Factor VII (rFVIIa), NovoSeven, NiaStase, Placebo | Joseph Broderick, MD, Novo Nordisk A/S, National Institute of Neurological Disorders and Stroke (NINDS) | Intracerebral Hemorrhage | 01/28 | 01/28 | | |
| Recruiting | 2 | 300 | US | TS23 | Translational Sciences, Inc., University of Cincinnati, National Institute of Neurological Disorders and Stroke (NINDS), Medical University of South Carolina, University of Arizona | Ischemic Stroke | 07/27 | 12/27 | | |
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial |
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| Active, not recruiting | N/A | 2486 | Europe, Canada, US, RoW | Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS | Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS) | Carotid Stenosis | 02/26 | 02/26 | | |
| Recruiting | N/A | 8000 | US | | Massachusetts General Hospital, National Institute of Neurological Disorders and Stroke (NINDS) | Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular, Mild Cognitive Impairment, Vascular Cognitive Impairment | 11/25 | 11/25 | | |
| Deleyrolle, Phuong |
| Completed | 2 | 175 | US | pp65-shLAMP DC with GM-CSF, pp65-shLAMP mRNA DCs with GM-CSF, unpulsed PBMC and saline, Peripheral Blood Mononuclear Cells, Td, Tetanus and Diphtheria Toxoid, Saline, Normal Saline, pp65-flLAMP DC with GM-CSF, pp65-flLAMP mRNA DCs with GM-CSF | University of Florida, National Cancer Institute (NCI) | Glioblastoma Multiforme, Glioblastoma, Malignant Glioma, Astrocytoma, Grade IV, GBM | 11/23 | 11/23 | | |
ADAGiO, NCT06254326: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients |
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| Active, not recruiting | 1 | 12 | US | TTRNA-DC vaccines with GM-CSF, Autologous Hematopoietic Stem cells (HSCs), TTRNA-xALT, Td vaccine | University of Florida, Oligo Nation, Inc | Recurrent Oligodendroglioma, Progressive Oligodendroglioma | 12/27 | 06/28 | | |
NCT06389591: RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM) |
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| Active, not recruiting | 1 | 24 | US | pp65 RNA loaded lipid particles, pp65 RNA-LPs (Drug Product 1 or DP1), RNA loaded lipid particles, RNA-LPs (Drug Product 2 or DP2) | University of Florida, National Cancer Institute (NCI) | Recurrent Glioblastoma | 12/27 | 12/28 | | |
IMPACT, NCT05353530: Phase I Study of IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma |
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| Recruiting | 1 | 18 | US | Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells, 8R-70CAR T cells | University of Florida, United States Department of Defense, AM Rosen Foundation | Glioblastoma Multiforme, Glioblastoma | 12/27 | 12/42 | | |
LIBERATE, NCT05383872: Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects with GlioBlastoma Brain Tumors |
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| Recruiting | N/A | 57 | Canada, US | Focused Ultrasound (Exablate Model 4000) | InSightec | Glioblastoma, Glioma, Liquid Biopsy | 12/24 | 03/25 | | |
NCT03671889: ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer's Disease |
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| Recruiting | N/A | 150 | US | Blood Brain Barrier (BBB) Disruption, ExAblate Neuro | InSightec | Alzheimer Disease | 12/25 | 12/25 | | |
| Wilson, Christina L |
| Terminated | N/A | 1 | US | Motivational Interview | University of Florida, Accreditation Council for Graduate Medical Education | Acute Stroke, Transient Ischemic Attack | 12/23 | 01/24 | | |
| Lyles, Teresa |
CREST-H, NCT03121209: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics |
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| Active, not recruiting | 3 | 385 | Canada, US | Revascularization, Intensive Medical Management (IMM) alone | Columbia University, National Institute of Neurological Disorders and Stroke (NINDS), Mayo Clinic, University of Alabama at Birmingham, University of Maryland, University of California, Los Angeles | Internal Carotid Artery Stenosis, Cognitive Impairment | 01/27 | 07/27 | | |
| Driscoll, Ian |
| Terminated | 3 | 2 | US | Harmonized supportive care, Etanercept 50 mg sc day 1 and day 4 | Vanderbilt University Medical Center, University of Ottawa, University of Toronto | Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses | 01/25 | 01/25 | | |
| Recruiting | N/A | 400 | Canada, US | Albumin Human, albumin | American Burn Association, United States Department of Defense | Burn Injury | 08/25 | 09/25 | | |
| Meyer, Dawn |
CAPTIVA, NCT05047172: Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis |
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| Recruiting | 3 | 1683 | US | Ticagrelor + Aspirin, Brilinta, Rivaroxaban + Aspirin, Xarelto, Clopidogrel + Aspirin, Plavix, Risk Factor Management | University of Florida, National Institute of Neurological Disorders and Stroke (NINDS), University of Cincinnati, Medical University of South Carolina, Janssen Scientific Affairs, LLC, AstraZeneca | Intracranial Arteriosclerosis, Stroke | 05/28 | 05/28 | | |
| Recruiting | N/A | 3062 | US | CPAP | University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), FusionHealth LLC, Medical University of South Carolina, University of Cincinnati | Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial | 11/26 | 11/26 | | |
| Lewis, Stephanie |
| Active, not recruiting | 1/2 | 125 | Europe, US | ST101, Temozolomide, Radiation | Sapience Therapeutics | Glioblastoma, Melanoma Stage IV, Breast Cancer, Prostate Cancer, Glioblastoma Multiforme, GBM, Brain Cancer, Metastatic Breast Cancer, Metastatic Melanoma, Metastatic Prostate Cancer, Melanoma Recurrent, Prostate Cancer Metastatic, Recurrent Glioblastoma, Newly Diagnosed Glioblastoma | 12/24 | 12/25 | | |
NCT05370508: A Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Subjects With Recurrent GBM |
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| Terminated | 1/2 | 8 | US | SONALA-001 (ALA) and MR-Guided Focused Ultrasound device (MRgFUS), Exablate Type 2.0 | SonALAsense, Inc. | Recurrent GBM | 06/24 | 07/24 | | |
| Active, not recruiting | 1 | 30 | US | Individualized therapy | Jennifer Clarke | Recurrent Glioblastoma | 11/23 | 12/26 | | |
FRONTIER, NCT05303467: A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM |
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| Active, not recruiting | 1 | 12 | US | TheraSphere GBM, TheraSphere™ GBM Y-90 Glass Microspheres (TheraSphere GBM) | Boston Scientific Corporation | Glioblastoma Multiforme, Recurrent Glioblastoma | 12/24 | 06/25 | | |
NCT06186401: Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells |
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| Recruiting | 1 | 20 | US | E-SYNC T Cells, Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13R alpha2 CAR T Cells, Autologous Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13R alpha2 CAR T Cells, Autologous Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ra2 CAR T Cells, Cyclophosphamide (non-investigational), Cytoxan, Cytoxan Lyophilized, Neosar, Fludarabine (non-investigational), Fludara, Oforta, Leukapheresis, Therapeutic Leukopheresis, Surgical resection, Resection | Hideho Okada, MD, PhD, California Institute for Regenerative Medicine (CIRM), National Cancer Institute (NCI) | EGFR Gene Mutation, Glioblastoma, MGMT-Unmethylated Glioblastoma, Recurrent Glioblastoma | 08/26 | 08/26 | | |
NCT05023551: Study of DSP-0390 in Patients with Recurrent High-Grade Glioma |
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| Active, not recruiting | 1 | 39 | Japan, US | DSP-0390 | Sumitomo Pharma America, Inc. | High Grade Glioma, Glioblastoma Multiforme | 09/26 | 10/26 | | |
NCT04656535: AB154 Combined with AB122 for Recurrent Glioblastoma |
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| Recruiting | 1 | 46 | US | Zimberelimab, Domvanalimab, Placebo | Yale University, National Cancer Institute (NCI), Arcus Biosciences, Inc. | Glioblastoma | 02/25 | 12/25 | | |
