UPMC Stroke Institute
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 9 Trials 
22 Trials

   

Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Jankowitz, Brian
SEAL™ IT, NCT05831202: SEAL™IT: Saccular Endovascular Aneurysm Lattice System Interventional Pivotal Trial

Recruiting
3
279
US
The SEAL™ Saccular Endovascular Aneurysm Lattice System
Galaxy Therapeutics INC
Intracranial Aneurysm
09/26
09/30
ATLAS, NCT02340585: Neuroform Atlas Stent System Study

Completed
N/A
298
US
Next Generation Neuroform Stent System
Stryker Neurovascular
Intracranial Aneurysm
12/21
09/22
NCT03865979: AI ENRICH - AI Detection of ICH

Completed
N/A
10
US
Viz RECRUIT
Viz.ai, Inc., Nico Corporation
Intracerebral Hemorrhage
03/23
04/23
EvaQ, NCT04437862: A Study to Evaluate the Q Revascularization System for Neurointervention in Acute Ischemic Stroke

Completed
N/A
121
Europe, US
Q Revascularization System
MIVI Neuroscience, Inc.
Acute Stroke, Cerebral Ischemia
04/23
08/23
NCT04129125: The Imperative Trial: Treatment of Acute Ischemic Stroke With the Zoom Reperfusion System

Completed
N/A
328
US
Zoom Reperfusion System
Imperative Care, Inc.
Ischemic Stroke, Acute Stroke
05/24
05/24
NCT05071963: INSPIRE Pipeline™ Shield Post Approval Study

Active, not recruiting
N/A
246
US
Treatment of Intracranial Aneurysms
Medtronic Neurovascular Clinical Affairs
Intracranial Aneurysm
03/26
04/28
SPLENDID, NCT06386289: Safety, Performance of CEREGLIDE 92 Intermediate Catheter in Treatment of Acute Ischemic Stroke

Not yet recruiting
N/A
140
US
Cereglide 92
Cerenovus, Part of DePuy Synthes Products, Inc.
Acute Ischemic Stroke
02/26
06/26
MIRROR, NCT04494295: The Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

Recruiting
N/A
500
US
Aurora Surgiscope System
Integra LifeSciences Corporation, Icahn School of Medicine at Mount Sinai, Oculus Imaging LLC
Supratentorial Hemorrhage
10/28
10/29
ROCHA, MARCELO EUSTÁQUIO DE SIQUEIRA E
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction

Terminated
3
535
Europe, Canada, Japan, US, RoW
BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo
Remedy Pharmaceuticals, Inc.
Brain Edema, Stroke, Acute
08/23
08/23
ESCAPE-NEXT, NCT04462536 / 2020-002360-30: Efficacy and Safety of Nerinetide in Participants With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy Excluding Thrombolysis

Completed
3
850
Europe, Canada, US, RoW
Placebo, Nerinetide, NA-1
NoNO Inc., University of Calgary
Stroke, Acute
08/23
08/23
ASPIRE, NCT03907046: Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Recruiting
3
700
US
Apixaban, Eliquis, Aspirin
Yale University, National Institute of Neurological Disorders and Stroke (NINDS)
Intracerebral Hemorrhage, Atrial Fibrillation
04/27
04/27
CREST-H, NCT03121209: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics

Active, not recruiting
3
385
Canada, US
Revascularization, Intensive Medical Management (IMM) alone
Columbia University, National Institute of Neurological Disorders and Stroke (NINDS), Mayo Clinic, University of Alabama at Birmingham, University of Maryland, University of California, Los Angeles
Internal Carotid Artery Stenosis, Cognitive Impairment
01/27
07/27
HEMERA-1, NCT04677777: Safety Study of PP-007 in Subjects With Acute Ischemic Stroke

Recruiting
1
24
US
PP-007 (Two doses administered 24±6 hours apart) + SOC (IVT or MT or IVT+MT), Sanguinate
Prolong Pharmaceuticals
Acute Ischemic Stroke
12/24
02/25
Feineigle, Patricia
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Mayo Clinic, National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
Clark, Wayne
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction

Terminated
3
535
Europe, Canada, Japan, US, RoW
BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo
Remedy Pharmaceuticals, Inc.
Brain Edema, Stroke, Acute
08/23
08/23
ASPIRE, NCT03907046: Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Recruiting
3
700
US
Apixaban, Eliquis, Aspirin
Yale University, National Institute of Neurological Disorders and Stroke (NINDS)
Intracerebral Hemorrhage, Atrial Fibrillation
04/27
04/27
RESCUE, NCT04693715: Safety of RNS60 in Large Vessel Occlusion Stroke Patients Undergoing Endovascular Thrombectomy

Completed
2
82
US
RNS60, Placebo
Revalesio Corporation
Stroke, Ischemic
11/23
11/23
HEMERA-1, NCT04677777: Safety Study of PP-007 in Subjects With Acute Ischemic Stroke

Recruiting
1
24
US
PP-007 (Two doses administered 24±6 hours apart) + SOC (IVT or MT or IVT+MT), Sanguinate
Prolong Pharmaceuticals
Acute Ischemic Stroke
12/24
02/25
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Mayo Clinic, National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
Sleep SMART, NCT03812653: Sleep for Stroke Management and Recovery Trial

Recruiting
N/A
3062
US
CPAP
University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), FusionHealth LLC, Medical University of South Carolina, University of Cincinnati
Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial
11/26
11/26
Gonzalez, Oscar
NCT06633822: Crown Lengthening in Aesthetic Anterior Sector by Means of Guided Digital Planning: Ramdomized Controlled Clinical Trial.

Recruiting
N/A
44
Europe
Digital planning, Analogic planning
Universidad Complutense de Madrid
Insufficient Clinical Crown Length
06/25
06/26
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Jankowitz, Brian
SEAL™ IT, NCT05831202: SEAL™IT: Saccular Endovascular Aneurysm Lattice System Interventional Pivotal Trial

Recruiting
3
279
US
The SEAL™ Saccular Endovascular Aneurysm Lattice System
Galaxy Therapeutics INC
Intracranial Aneurysm
09/26
09/30
ATLAS, NCT02340585: Neuroform Atlas Stent System Study

Completed
N/A
298
US
Next Generation Neuroform Stent System
Stryker Neurovascular
Intracranial Aneurysm
12/21
09/22
NCT03865979: AI ENRICH - AI Detection of ICH

Completed
N/A
10
US
Viz RECRUIT
Viz.ai, Inc., Nico Corporation
Intracerebral Hemorrhage
03/23
04/23
EvaQ, NCT04437862: A Study to Evaluate the Q Revascularization System for Neurointervention in Acute Ischemic Stroke

Completed
N/A
121
Europe, US
Q Revascularization System
MIVI Neuroscience, Inc.
Acute Stroke, Cerebral Ischemia
04/23
08/23
NCT04129125: The Imperative Trial: Treatment of Acute Ischemic Stroke With the Zoom Reperfusion System

Completed
N/A
328
US
Zoom Reperfusion System
Imperative Care, Inc.
Ischemic Stroke, Acute Stroke
05/24
05/24
NCT05071963: INSPIRE Pipeline™ Shield Post Approval Study

Active, not recruiting
N/A
246
US
Treatment of Intracranial Aneurysms
Medtronic Neurovascular Clinical Affairs
Intracranial Aneurysm
03/26
04/28
SPLENDID, NCT06386289: Safety, Performance of CEREGLIDE 92 Intermediate Catheter in Treatment of Acute Ischemic Stroke

Not yet recruiting
N/A
140
US
Cereglide 92
Cerenovus, Part of DePuy Synthes Products, Inc.
Acute Ischemic Stroke
02/26
06/26
MIRROR, NCT04494295: The Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

Recruiting
N/A
500
US
Aurora Surgiscope System
Integra LifeSciences Corporation, Icahn School of Medicine at Mount Sinai, Oculus Imaging LLC
Supratentorial Hemorrhage
10/28
10/29
ROCHA, MARCELO EUSTÁQUIO DE SIQUEIRA E
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction

Terminated
3
535
Europe, Canada, Japan, US, RoW
BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo
Remedy Pharmaceuticals, Inc.
Brain Edema, Stroke, Acute
08/23
08/23
ESCAPE-NEXT, NCT04462536 / 2020-002360-30: Efficacy and Safety of Nerinetide in Participants With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy Excluding Thrombolysis

Completed
3
850
Europe, Canada, US, RoW
Placebo, Nerinetide, NA-1
NoNO Inc., University of Calgary
Stroke, Acute
08/23
08/23
ASPIRE, NCT03907046: Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Recruiting
3
700
US
Apixaban, Eliquis, Aspirin
Yale University, National Institute of Neurological Disorders and Stroke (NINDS)
Intracerebral Hemorrhage, Atrial Fibrillation
04/27
04/27
CREST-H, NCT03121209: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics

Active, not recruiting
3
385
Canada, US
Revascularization, Intensive Medical Management (IMM) alone
Columbia University, National Institute of Neurological Disorders and Stroke (NINDS), Mayo Clinic, University of Alabama at Birmingham, University of Maryland, University of California, Los Angeles
Internal Carotid Artery Stenosis, Cognitive Impairment
01/27
07/27
HEMERA-1, NCT04677777: Safety Study of PP-007 in Subjects With Acute Ischemic Stroke

Recruiting
1
24
US
PP-007 (Two doses administered 24±6 hours apart) + SOC (IVT or MT or IVT+MT), Sanguinate
Prolong Pharmaceuticals
Acute Ischemic Stroke
12/24
02/25
Feineigle, Patricia
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Mayo Clinic, National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
Clark, Wayne
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction

Terminated
3
535
Europe, Canada, Japan, US, RoW
BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo
Remedy Pharmaceuticals, Inc.
Brain Edema, Stroke, Acute
08/23
08/23
ASPIRE, NCT03907046: Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

Recruiting
3
700
US
Apixaban, Eliquis, Aspirin
Yale University, National Institute of Neurological Disorders and Stroke (NINDS)
Intracerebral Hemorrhage, Atrial Fibrillation
04/27
04/27
RESCUE, NCT04693715: Safety of RNS60 in Large Vessel Occlusion Stroke Patients Undergoing Endovascular Thrombectomy

Completed
2
82
US
RNS60, Placebo
Revalesio Corporation
Stroke, Ischemic
11/23
11/23
HEMERA-1, NCT04677777: Safety Study of PP-007 in Subjects With Acute Ischemic Stroke

Recruiting
1
24
US
PP-007 (Two doses administered 24±6 hours apart) + SOC (IVT or MT or IVT+MT), Sanguinate
Prolong Pharmaceuticals
Acute Ischemic Stroke
12/24
02/25
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Mayo Clinic, National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
Sleep SMART, NCT03812653: Sleep for Stroke Management and Recovery Trial

Recruiting
N/A
3062
US
CPAP
University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), FusionHealth LLC, Medical University of South Carolina, University of Cincinnati
Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial
11/26
11/26
Gonzalez, Oscar
NCT06633822: Crown Lengthening in Aesthetic Anterior Sector by Means of Guided Digital Planning: Ramdomized Controlled Clinical Trial.

Recruiting
N/A
44
Europe
Digital planning, Analogic planning
Universidad Complutense de Madrid
Insufficient Clinical Crown Length
06/25
06/26

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