Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC GINECOLOGIA ONCOLOGICA
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 24 Trials 
22 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Scambia, Giovanni
NCT04460807 / 2018-000693-30: Exemestane in Hormone Receptor Positive High Grade Ovarian Cancer

Terminated
3
23
Europe
Exemestane, Mestane, Placebo oral tablet
Ente Ospedaliero Ospedali Galliera, Istituto Di Ricerche Farmacologiche Mario Negri, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Federation of Italian Cooperative Oncology Groups
Ovarian Cancer
04/23
04/23
NCT02584478 / 2021-003871-32: Phase 1/2a/3 Evaluation of Adding AL3818 to Standard Platinum-Based Chemotherapy in Subjects With Recurrent or Metastatic Endometrial, Ovarian, Fallopian, Primary Peritoneal or Cervical Carcinoma (AL3818-US-002)

Active, not recruiting
3
294
Europe, US, RoW
AL3818, Anlotinib Hydrochloride, Anlotinib, Catequentinib, Paclitaxel, Pegylated Liposomal Doxorubicin (PLD), Topotecan, Daily Topotecan, Weekly Topotecan, Carboplatin, Paraplatin, Taxol
Advenchen Laboratories, LLC, Advenchen Laboratories, LLC
Endometrial Carcinoma, Ovarian Carcinoma, Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma, Cervical Carcinoma
10/24
12/24
FLORA-4, NCT04498117 / 2020-002270-26: Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery

Active, not recruiting
3
615
Europe, Canada, US, RoW
Oregovomab, MAb-B43.13, Paclitaxel, Taxol, Carboplatin, Paraplatin, Placebo
CanariaBio Inc., Gynecologic Oncology Group, Iqvia Pty Ltd
Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma, Fallopian Tube Neoplasms, Fallopian Tube Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Peritoneal Cancer, Peritoneal Carcinoma, Peritoneal Neoplasms
09/25
08/27
NUVOLA, NCT04261465: TRIAL Open-label Multicentre Study

Recruiting
2
35
Europe
Olaparib, Lynparza, Paclitaxel, Carboplatin
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
High Grade Serous Ovarian Cancer
12/20
12/22
PYNNACLE, NCT04585750: The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation

Recruiting
1/2
230
Europe, US, RoW
rezatapopt, PC14586, pembrolizumab, KEYTRUDA®, MK-3475, KEYNOTE-D79, MK-3475-D79
PMV Pharmaceuticals, Inc, Merck Sharp & Dohme LLC
Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor, Lung Cancer, Ovarian Cancer, Endometrial Cancer, Prostate Cancer, Colorectal Cancer, Breast Cancer, Other Cancer, Locally Advanced, Head and Neck Cancer, Gall Bladder Cancer, Small Cell Lung Cancer, Small Cell Lung Cancer ( SCLC ), Small Cell Lung Carcinoma, NSCLC, NSCLC (Non-small Cell Lung Cancer), SCLC, Non-Small Cell Lung Carcinoma, Triple Negative Breast Cancer, TNBC, HER2+ Breast Cancer, Non-Small Cell Lung Cancer, ER/PR Positive Breast Cancer, HER2- Breast Cancer, HER2-positive Breast Cancer, HER2-negative Breast Cancer, ER/PR(+), Her2(-) Breast Cancer
03/26
07/26
GO-VAC, NCT04584957: Prophylactic Negative Pressure Wound Therapy (VAC) in Gynecologic Oncology (G.O.)

Active, not recruiting
N/A
196
Europe
VAC therapy
Catholic University of the Sacred Heart
Wound Infection, Gynecologic Cancer
09/21
09/21
MYLUNAR, NCT04123158: MYometrial Lesion UltrasouNd And mRi

Completed
N/A
2353
Europe
Ultrasound, MRI
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Prof. Antonia Testa, Dr. Daniela Romualdi, Dr. Francesca Ciccarone
Sarcoma Uterus
12/23
12/23
CLESS, NCT04178876: Comparison of Laparoscopic Endometrioma Stripping Versus Ethanol Sclerotherapy( )

Recruiting
N/A
64
Europe
ethanol sclerotherapy, stripping technique
Catholic University of the Sacred Heart
Endometrioma
11/22
06/23
FPG-500, NCT06020625: Mutational Oncology in Clinical Practice

Recruiting
N/A
20000
Europe
Diagnostic Test
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Genome Instability, Genetic Predisposition to Disease, Gene Rearrangement
05/23
01/32
NCT04291612: Observational Study of Women With Endometrial Cancer Who Receive the Standard Treatment for Their Disease

Recruiting
N/A
1400
Europe, US, RoW
Physical exam
Memorial Sloan Kettering Cancer Center
Endometrial Cancer, Endometrioid Adenocarcinoma, Endometrial Cancer Stage I
02/25
02/25
R-LYNUS, NCT06621823: Image-guided Ultrasound Robotic Intraoperative Evaluation of Lymph-nodes Status in Gynecological Malignancies

Recruiting
N/A
160
Europe
image-guided surgery technique
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lymph Node Metastasis, Gynecologic Cancer
12/24
05/26
G-AYA, NCT06594471: Comprehensive Assessment of Clinical Characteristics and Outcomes of Gemelli Adolescents and Young Adults

Not yet recruiting
N/A
500
Europe
Questionnaire on late-term physical effects, Questionnaire on sexual and reproductive health outcomes, Questionnaire on psychological outcomes, Questionnaire on social outcomes
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gynecologic Cancer
09/39
03/40
LYSE, NCT06619002: Implementation of Surgical Safety and Intraoperative Metastasis Identification Through Deep Learning: Multicentric Video Collection for Minimally Invasive Sentinel Lymph Node Dissection in Uterine Malignancies

Recruiting
N/A
100
Europe
Sentinel lymph node sampling, sentinel lymph node detection, sentinel lymph node dissection, sentinel lymph node biopsy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, IHU Strasbourg, University Hospital, Strasbourg
Endometrial Cancer, Cervical Cancer, Deep Learning, Artificial Intelligence
09/26
09/27
LASH, NCT06416748: Minimally Invasive Simple Hysterectomy in Low Risk Cervical Cancer

Recruiting
N/A
974
Europe
Minimally invasive simple hysterectomy, simple hysterectomy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervical Cancer, Cervix Cancer
07/27
07/30
GEN&RARE, NCT06926127: Genomic Profiling of Genetic and Rare Diseases

Recruiting
N/A
1500
Europe
Whole Exome Sequencing (WES)
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rare Diseases, Genetic Disease
04/26
02/30
Immuno-Gyn, NCT06737640: Evaluation of Clinical and Molecular Biomarkers in Immunotherapy Treatment in Gynecologic Cancer

Not yet recruiting
N/A
90
Europe
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervical Cancer, Endometrial Cancer
12/25
12/26
SOLAR, NCT06832397: Detection of Peritoneal Metastases by Diagnostic LAparoscopy in Patients With Locally Advanced Cervical Carcinoma

Not yet recruiting
N/A
120
Europe
Diagnostic laparoscopy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervical Cancer
02/28
02/31
STORY, NCT06802198: A Randomized Study Comparing Subtotal vs Total Hysterectomy Long Term Outcomes

Not yet recruiting
N/A
500
Europe
total hysterectomy, subtotal hysterectomy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fibroid Uterus, Metrorrhagia, Adenomyosis, Benign Gynecologic Neoplasm, Endometriosis, Abnormal Uterine Bleeding
02/28
02/30
IMMUNO_ASSAY, NCT06797479: Detection of Circulating Therapeutic Monoclonal Antibodies in Biological Samples of Gynecological Cancer Patients.

Not yet recruiting
N/A
12
NA
Blood samples for the analysis of sildenafil in plasma
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gynecological Cancer, Immunotherapy
03/30
12/30
MIPEX, NCT06867445: Minimally Invasive Pelvic Exenteration in Vaginal or Cervical Cancer Recurrence

Recruiting
N/A
64
Europe
Minimally invasive pelvic exenteration
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervical Cancers, Vaginal Cancers
03/28
03/31
TAILOR, NCT04555473: Translational Analysis In Longitudinal Series of Ovarian Cancer ORganoids

Recruiting
N/A
48
Europe
Tumor biopsy, Blood sampling
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Organoids, Epithelial Ovarian Cancer
11/21
05/23
Panico, Giovanni
STORY, NCT06802198: A Randomized Study Comparing Subtotal vs Total Hysterectomy Long Term Outcomes

Not yet recruiting
N/A
500
Europe
total hysterectomy, subtotal hysterectomy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fibroid Uterus, Metrorrhagia, Adenomyosis, Benign Gynecologic Neoplasm, Endometriosis, Abnormal Uterine Bleeding
02/28
02/30
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Scambia, Giovanni
NCT04460807 / 2018-000693-30: Exemestane in Hormone Receptor Positive High Grade Ovarian Cancer

Terminated
3
23
Europe
Exemestane, Mestane, Placebo oral tablet
Ente Ospedaliero Ospedali Galliera, Istituto Di Ricerche Farmacologiche Mario Negri, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Federation of Italian Cooperative Oncology Groups
Ovarian Cancer
04/23
04/23
NCT02584478 / 2021-003871-32: Phase 1/2a/3 Evaluation of Adding AL3818 to Standard Platinum-Based Chemotherapy in Subjects With Recurrent or Metastatic Endometrial, Ovarian, Fallopian, Primary Peritoneal or Cervical Carcinoma (AL3818-US-002)

Active, not recruiting
3
294
Europe, US, RoW
AL3818, Anlotinib Hydrochloride, Anlotinib, Catequentinib, Paclitaxel, Pegylated Liposomal Doxorubicin (PLD), Topotecan, Daily Topotecan, Weekly Topotecan, Carboplatin, Paraplatin, Taxol
Advenchen Laboratories, LLC, Advenchen Laboratories, LLC
Endometrial Carcinoma, Ovarian Carcinoma, Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma, Cervical Carcinoma
10/24
12/24
FLORA-4, NCT04498117 / 2020-002270-26: Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery

Active, not recruiting
3
615
Europe, Canada, US, RoW
Oregovomab, MAb-B43.13, Paclitaxel, Taxol, Carboplatin, Paraplatin, Placebo
CanariaBio Inc., Gynecologic Oncology Group, Iqvia Pty Ltd
Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma, Fallopian Tube Neoplasms, Fallopian Tube Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Peritoneal Cancer, Peritoneal Carcinoma, Peritoneal Neoplasms
09/25
08/27
NUVOLA, NCT04261465: TRIAL Open-label Multicentre Study

Recruiting
2
35
Europe
Olaparib, Lynparza, Paclitaxel, Carboplatin
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
High Grade Serous Ovarian Cancer
12/20
12/22
PYNNACLE, NCT04585750: The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation

Recruiting
1/2
230
Europe, US, RoW
rezatapopt, PC14586, pembrolizumab, KEYTRUDA®, MK-3475, KEYNOTE-D79, MK-3475-D79
PMV Pharmaceuticals, Inc, Merck Sharp & Dohme LLC
Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor, Lung Cancer, Ovarian Cancer, Endometrial Cancer, Prostate Cancer, Colorectal Cancer, Breast Cancer, Other Cancer, Locally Advanced, Head and Neck Cancer, Gall Bladder Cancer, Small Cell Lung Cancer, Small Cell Lung Cancer ( SCLC ), Small Cell Lung Carcinoma, NSCLC, NSCLC (Non-small Cell Lung Cancer), SCLC, Non-Small Cell Lung Carcinoma, Triple Negative Breast Cancer, TNBC, HER2+ Breast Cancer, Non-Small Cell Lung Cancer, ER/PR Positive Breast Cancer, HER2- Breast Cancer, HER2-positive Breast Cancer, HER2-negative Breast Cancer, ER/PR(+), Her2(-) Breast Cancer
03/26
07/26
GO-VAC, NCT04584957: Prophylactic Negative Pressure Wound Therapy (VAC) in Gynecologic Oncology (G.O.)

Active, not recruiting
N/A
196
Europe
VAC therapy
Catholic University of the Sacred Heart
Wound Infection, Gynecologic Cancer
09/21
09/21
MYLUNAR, NCT04123158: MYometrial Lesion UltrasouNd And mRi

Completed
N/A
2353
Europe
Ultrasound, MRI
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Prof. Antonia Testa, Dr. Daniela Romualdi, Dr. Francesca Ciccarone
Sarcoma Uterus
12/23
12/23
CLESS, NCT04178876: Comparison of Laparoscopic Endometrioma Stripping Versus Ethanol Sclerotherapy( )

Recruiting
N/A
64
Europe
ethanol sclerotherapy, stripping technique
Catholic University of the Sacred Heart
Endometrioma
11/22
06/23
FPG-500, NCT06020625: Mutational Oncology in Clinical Practice

Recruiting
N/A
20000
Europe
Diagnostic Test
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Genome Instability, Genetic Predisposition to Disease, Gene Rearrangement
05/23
01/32
NCT04291612: Observational Study of Women With Endometrial Cancer Who Receive the Standard Treatment for Their Disease

Recruiting
N/A
1400
Europe, US, RoW
Physical exam
Memorial Sloan Kettering Cancer Center
Endometrial Cancer, Endometrioid Adenocarcinoma, Endometrial Cancer Stage I
02/25
02/25
R-LYNUS, NCT06621823: Image-guided Ultrasound Robotic Intraoperative Evaluation of Lymph-nodes Status in Gynecological Malignancies

Recruiting
N/A
160
Europe
image-guided surgery technique
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lymph Node Metastasis, Gynecologic Cancer
12/24
05/26
G-AYA, NCT06594471: Comprehensive Assessment of Clinical Characteristics and Outcomes of Gemelli Adolescents and Young Adults

Not yet recruiting
N/A
500
Europe
Questionnaire on late-term physical effects, Questionnaire on sexual and reproductive health outcomes, Questionnaire on psychological outcomes, Questionnaire on social outcomes
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gynecologic Cancer
09/39
03/40
LYSE, NCT06619002: Implementation of Surgical Safety and Intraoperative Metastasis Identification Through Deep Learning: Multicentric Video Collection for Minimally Invasive Sentinel Lymph Node Dissection in Uterine Malignancies

Recruiting
N/A
100
Europe
Sentinel lymph node sampling, sentinel lymph node detection, sentinel lymph node dissection, sentinel lymph node biopsy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, IHU Strasbourg, University Hospital, Strasbourg
Endometrial Cancer, Cervical Cancer, Deep Learning, Artificial Intelligence
09/26
09/27
LASH, NCT06416748: Minimally Invasive Simple Hysterectomy in Low Risk Cervical Cancer

Recruiting
N/A
974
Europe
Minimally invasive simple hysterectomy, simple hysterectomy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervical Cancer, Cervix Cancer
07/27
07/30
GEN&RARE, NCT06926127: Genomic Profiling of Genetic and Rare Diseases

Recruiting
N/A
1500
Europe
Whole Exome Sequencing (WES)
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rare Diseases, Genetic Disease
04/26
02/30
Immuno-Gyn, NCT06737640: Evaluation of Clinical and Molecular Biomarkers in Immunotherapy Treatment in Gynecologic Cancer

Not yet recruiting
N/A
90
Europe
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervical Cancer, Endometrial Cancer
12/25
12/26
SOLAR, NCT06832397: Detection of Peritoneal Metastases by Diagnostic LAparoscopy in Patients With Locally Advanced Cervical Carcinoma

Not yet recruiting
N/A
120
Europe
Diagnostic laparoscopy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervical Cancer
02/28
02/31
STORY, NCT06802198: A Randomized Study Comparing Subtotal vs Total Hysterectomy Long Term Outcomes

Not yet recruiting
N/A
500
Europe
total hysterectomy, subtotal hysterectomy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fibroid Uterus, Metrorrhagia, Adenomyosis, Benign Gynecologic Neoplasm, Endometriosis, Abnormal Uterine Bleeding
02/28
02/30
IMMUNO_ASSAY, NCT06797479: Detection of Circulating Therapeutic Monoclonal Antibodies in Biological Samples of Gynecological Cancer Patients.

Not yet recruiting
N/A
12
NA
Blood samples for the analysis of sildenafil in plasma
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gynecological Cancer, Immunotherapy
03/30
12/30
MIPEX, NCT06867445: Minimally Invasive Pelvic Exenteration in Vaginal or Cervical Cancer Recurrence

Recruiting
N/A
64
Europe
Minimally invasive pelvic exenteration
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervical Cancers, Vaginal Cancers
03/28
03/31
TAILOR, NCT04555473: Translational Analysis In Longitudinal Series of Ovarian Cancer ORganoids

Recruiting
N/A
48
Europe
Tumor biopsy, Blood sampling
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Organoids, Epithelial Ovarian Cancer
11/21
05/23
Panico, Giovanni
STORY, NCT06802198: A Randomized Study Comparing Subtotal vs Total Hysterectomy Long Term Outcomes

Not yet recruiting
N/A
500
Europe
total hysterectomy, subtotal hysterectomy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fibroid Uterus, Metrorrhagia, Adenomyosis, Benign Gynecologic Neoplasm, Endometriosis, Abnormal Uterine Bleeding
02/28
02/30

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