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9 Active 3 Inactive 12 All	Not yet recruiting Recruiting Enrolling by invitation Active, not recruiting Available No longer recruiting	Industry lead sponsor Industry collaborator Coop Other	US Canada Japan Europe RoW	N/A 1 2 3 4	Highlight changes:- Show only changed items Enrollment:

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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
Testa, Luca
XLIMIT, NCT03745053: XLIMus Drug Eluting Stent: a randomIzed Controlled Trial to Assess Endothelization	Completed	N/A	180	Europe	Xlimus DES Implantation during coronary angioplasty, Synergy DES Implantation during coronary angioplasty	Cardionovum GmbH, Mediolanum Cardio Research	Coronary Artery Disease	09/23	09/23
FAST III, NCT04931771: Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR Guided Revascularization	Recruiting	N/A	2228	Europe	vFFR guided revascularization, FFR guided revascularization	ECRI bv, Siemens Healthineers AG, Pie Medical Imaging	Coronary Artery Disease	05/25	05/25
OPTIMAL, NCT04111770: The Randomized Controlled Trial	Active, not recruiting	N/A	807	Europe	IVUS guided Percutaneous Coronary Intervention, QCA guided Percutaneous Coronary Intervention	ECRI bv, Philips Healthcare, Boston Scientific Corporation	Left Main Coronary Artery Stenosis	07/25	07/25
PROTECT IV, NCT04763200: Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function	Recruiting	N/A	1252	Europe, Canada, US	Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump	Abiomed Inc.	Left Ventricular Dysfunction, Coronary Artery Disease	03/26	10/27
Vaglimigli, Marco
PROTECT IV, NCT04763200: Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function	Recruiting	N/A	1252	Europe, Canada, US	Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump	Abiomed Inc.	Left Ventricular Dysfunction, Coronary Artery Disease	03/26	10/27
Tarantini, Guiseppe
NCT05844969: Circle Method Observational Project - Non-interventional, Retrospective, Multicenter Data Collection	Not yet recruiting	N/A	60	Europe		Institut für Pharmakologie und Präventive Medizin, Edwards Lifesciences	Aortic Stenosis With Bicuspid Valve	08/25	08/25
PROTECT IV, NCT04763200: Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function	Recruiting	N/A	1252	Europe, Canada, US	Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®, IABP Intra-aortic balloon pump	Abiomed Inc.	Left Ventricular Dysfunction, Coronary Artery Disease	03/26	10/27