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4 Active 0 Inactive 4 All	Not yet recruiting Recruiting Enrolling by invitation Active, not recruiting Available No longer recruiting	Industry lead sponsor Industry collaborator Coop Other	US Canada Japan Europe RoW	N/A 1 2 3 4	Highlight changes:- Show only changed items Enrollment:

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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
Dupont, Allison
NCT05425459: RESPONDER-HF Trial	Recruiting	N/A	750	Europe, Canada, US, RoW	Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)	Corvia Medical	Heart Failure, Heart Failure, Diastolic	05/25	03/31
EMPOWER CAD, NCT05755711: Equity in Modifying Plaque Of WomEn With UndeRtreated Calcified Coronary Artery Disease	Active, not recruiting	N/A	399	Europe, US	Shockwave Medical Coronary IVL System	Shockwave Medical, Inc.	Coronary Artery Disease	12/24	04/28
FROST-HF, NCT05136820: Flow Regulation by Opening the SepTum in Patients With Heart Failure; a Prospective, Randomized, Sham-controlled, Double-blind, Global Multicenter Study	Active, not recruiting	N/A	698	US	Atrial Flow Regulator, AFR, Sham Comparator	Occlutech International AB	Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Reduced Ejection Fraction (HFrEF)	02/26	02/29
Bain, Marriane
NCT05425459: RESPONDER-HF Trial	Recruiting	N/A	750	Europe, Canada, US, RoW	Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)	Corvia Medical	Heart Failure, Heart Failure, Diastolic	05/25	03/31