University of Calgary - Foothills Medical Centre
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 20 Trials 
49 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Hill, Michael D
PLATINUM, NCT04443608: Patiromer Utility as an Adjunct Treatment in Patients Needing Urgent Hyperkalemia Management

Terminated
4
115
US
Patiromer Powder for Oral Suspension [Veltassa], Active drug, Placebo, Inactive substance
Comprehensive Research Associates
Hyperkalemia
03/23
06/23
ESCAPE-NEXT, NCT04462536 / 2020-002360-30: Efficacy and Safety of Nerinetide in Participants With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy Excluding Thrombolysis

Completed
3
850
Europe, Canada, US, RoW
Placebo, Nerinetide, NA-1
NoNO Inc., University of Calgary
Stroke, Acute
08/23
08/23
ACT-WHEN, NCT06320431: ACT-GLOBAL THROMBOLYSIS (-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632

Recruiting
3
4000
Canada, RoW
Tenecteplase, TNKase, Metalyse
University of Calgary, The George Institute for Global Health, Australia
Acute Ischemic Stroke AIS, Stroke Acute, Stroke, Acute, Stroke Ischemic
09/30
12/30
ACT-GLOBAL, NCT06352632: Adaptive Platform Trial for Stroke

Recruiting
3
20000
Canada, RoW
Standard-dose intravenous tenecteplase, Low-dose intravenous tenecteplase, No intravenous tenecteplase, Conservative Blood Pressure Control, Moderate Blood Pressure Control, Intensive Blood Pressure Control, Placebo, NoNO-42, No deferoxamine mesylate and no colchicine, Deferoxamine mesylate only, Colchicine only, Both deferoxamine mesylate and colchicine
The George Institute, University of Calgary, Berry Consultants
Stroke
09/34
09/34
TEMPO-2, NCT02398656: A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion

Completed
3
1274
Europe, Canada, RoW
Tenecteplase, TNK-tPA, Antiplatelet treatment, ASA, Clopidogrel
University of Calgary
Stroke, Acute
01/24
04/24
ENDOLOW, NCT04167527: Endovascular Therapy for Low NIHSS Ischemic Strokes

Recruiting
2/3
200
Europe, Canada, US
Immediate mechanical thrombectomy(iMT) using EmboTrap Revascularization Device, EmboTrap III, Initial medical management (iMM)
Emory University, University of Calgary, University of Cincinnati, Heidelberg University, Children's Hospital Medical Center, Cincinnati
Cerebral Ischemia
12/24
12/24
NCT05123755: Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.

Recruiting
2a
120
US
AV-001 Injection, AV-001 Placebo Injection
Vasomune Therapeutics, Inc.
Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral, Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
12/24
03/25
KOURAGE, NCT06374797: A Study of Auxora in Patients with AKI and Injurious Lung "Crosstalk"

Recruiting
2
150
US
Auxora, Placebo
CalciMedica, Inc.
Acute Kidney Injury
08/25
08/25
RAISE, NCT06226805: Study of BB-031 in Acute Ischemic Stroke Patients

Recruiting
2
156
US, RoW
BB-031, DTRI-031, Placebo, Saline
Basking Biosciences, Inc.
Acute Ischemic Stroke
12/26
03/27
CARPO, NCT04681066: A Study of Auxora in Patients With Acute Pancreatitis and Accompanying SIRS

Completed
2
216
US, RoW
CM-4620 Injectable Emulsion or CM-4620-IE, Auxora, Placebo
CalciMedica, Inc.
Acute Pancreatitis, Systemic Inflammatory Response Syndrome
05/24
05/24
NCT06403267: NoNO-42 Trial in Acute Ischemic Stroke Patients Selected for Thrombolysis with or Without Endovascular Thrombectomy

Recruiting
2
600
Canada
NoNO-42, Placebo, Control
NoNO Inc.
Acute Ischemic Stroke
05/26
05/26
ACST-2, NCT00883402: Carotid Endarterectomy Versus Carotid Artery Stenting in Asymptomatic Patients

Active, not recruiting
N/A
3638
Europe, Canada, Japan, US, RoW
CEA, CAS
University of Oxford, NHS Health Technology Assessment Programme, BUPA Foundation, British Heart Foundation
Carotid Stenosis
12/20
12/25
Tension, NCT03094715: Efficacy and Safety of Thrombectomy in Stroke With Extended Lesion and Extended Time Window

Terminated
N/A
253
Europe, Canada, RoW
Thrombectomy, Mechanical thrombectomy, Best medical care, Control group
University Hospital Heidelberg, Karolinska University Hospital, Eppdata GmbH Hamburg, Germany, Aarhus University Hospital, Medical University Innsbruck, Groupe Hospitalier Pitie-Salpetriere, Oslo University Hospital, University Hospital, Martin, Charles University, Czech Republic, Hospices Civils de Lyon, CHU de Reims, Epidemiological and Clinical Research Information Network, STROKE ALLIANCE FOR EUROPE, International Consortium for Health Outcome Measurement, Inc., Europan Society for Minimally Invasive Neurological Therapy, Universitätsklinikum Hamburg-Eppendorf
Stroke, Acute, Cerebral Stroke, Cerebrovascular Stroke, Apoplexy; Brain
05/23
11/23
ENCHANTED3/MT, NCT06352619: Third Enhanced Control of Hypertension and Thrombectomy Stroke Domain Within ACT-GLOBAL Adaptive Platform Trial

Recruiting
N/A
2000
Canada, RoW
Conservative SBP Control, Moderate SBP Control, Intensive SBP Control
The George Institute, University of Calgary, Changhai Hospital
Ischemic Stroke, Acute
05/26
05/26
Tremblay, Alain
CATCO, NCT04330690: Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial

Active, not recruiting
3
2900
Canada
Artesunate, Imatinib, Infliximab, Dexamethasone, LSALT Peptide
Sunnybrook Health Sciences Centre, AbbVie, Apotex Inc., World Health Organization, University of British Columbia, Arch Biopartners Inc.
COVID-19
03/24
05/24
NCT02431962: Alberta Lung Cancer Screening Program

Active, not recruiting
N/A
800
Canada
Computed Tomography, Active smokers - Smoking cessation arm, Active smokers - Control arm
University of Calgary, Alberta Cancer Foundation
Lung Neoplasms, Respiratory Tract Neoplasms
12/19
12/22
NCT03809169: Peripheral EBUS With ROSE vs no ROSE; Slim Bronchoscope Without Guide Sheath vs Standard Bronchoscope With Guide Sheath

Completed
N/A
186
Canada
Rapid on-site evaluation (ROSE), Slim bronchoscope without a guide sheath, Ultrathin bronchoscope with pEBUS, Standard pEBUS with guide sheath
University of Calgary, McGill University, Laval University
Peripheral Pulmonary Lesions, Lung Cancer
03/24
09/24
ALTITUDE, NCT04171492: Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules

Recruiting
N/A
2000
Canada, US
Biodesix, Inc.
Nodule Solitary Pulmonary, Non-small Cell Carcinoma
12/24
12/26
Har, Bryan J
STRIVE, NCT03335839: Adjunctive, Low-dose tPA in Primary PCI for STEMI

Active, not recruiting
3
210
Canada
tissue plasminogen activator, Saline
Population Health Research Institute, Heart and Stroke Foundation of Canada
Myocardial Infarction, Percutaneous Coronary Intervention
09/24
10/24
DTU-STEMI, NCT03947619: Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: the STEMI-DTU Trial

Active, not recruiting
N/A
527
Europe, Canada, US
Impella CP® placement prior to reperfusion with Primary PCI
Abiomed Inc.
ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
09/24
10/30
COMPLETE-2, NCT05701358: Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

Recruiting
N/A
5100
Europe, Canada, US
Physiology-guided NCL PCI, Angiography-guided NCL PCI
Population Health Research Institute
Acute Myocardial Infarction, Coronary Artery Disease
06/28
06/28
NCT05427370: The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)

Recruiting
N/A
754
Europe, Canada, US, RoW
Revascularization by PCI, Revascularization by CABG
Sunnybrook Health Sciences Centre, Canadian Institutes of Health Research (CIHR), Weill Medical College of Cornell University
Coronary Artery Disease, Heart Failure Systolic
04/29
12/29
Demchuk, Andrew
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction

Terminated
3
535
Europe, Canada, Japan, US, RoW
BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo
Remedy Pharmaceuticals, Inc.
Brain Edema, Stroke, Acute
08/23
08/23
ESCAPE-NEXT, NCT04462536 / 2020-002360-30: Efficacy and Safety of Nerinetide in Participants With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy Excluding Thrombolysis

Completed
3
850
Europe, Canada, US, RoW
Placebo, Nerinetide, NA-1
NoNO Inc., University of Calgary
Stroke, Acute
08/23
08/23
ACT-GLOBAL, NCT06352632: Adaptive Platform Trial for Stroke

Recruiting
3
20000
Canada, RoW
Standard-dose intravenous tenecteplase, Low-dose intravenous tenecteplase, No intravenous tenecteplase, Conservative Blood Pressure Control, Moderate Blood Pressure Control, Intensive Blood Pressure Control, Placebo, NoNO-42, No deferoxamine mesylate and no colchicine, Deferoxamine mesylate only, Colchicine only, Both deferoxamine mesylate and colchicine
The George Institute, University of Calgary, Berry Consultants
Stroke
09/34
09/34
FASTEST, NCT03496883: Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial

Recruiting
3
860
Europe, Canada, Japan, US
Recombinant Activated Factor VII (rFVIIa), NovoSeven, NiaStase, Placebo
Joseph Broderick, MD, Novo Nordisk A/S, National Institute of Neurological Disorders and Stroke (NINDS)
Intracerebral Hemorrhage
01/28
01/28
ESCAPE-MeVO, NCT05151172: EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions ( Trial)

Active, not recruiting
N/A
530
Europe, Canada, US
endovascular thrombectomy (EVT), solitaire X, Standarad medical care
Dr. Michael D Hill, University of Calgary
Acute Ischemic Stroke
12/25
06/26
Goyal, Mayank
EVOLVE, NCT04192955: Evaluating Oral Peri-operative Acetylsalicylic Acid in Subjects Undergoing Endovascular Coiling-only of Unruptured Brain Aneurysms

Recruiting
3
440
Europe, Canada
Acetyl Salicylate
University of Calgary
Unruptured Cerebral Aneurysm
09/24
12/24
ESCAPE-MeVO, NCT05151172: EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions ( Trial)

Active, not recruiting
N/A
530
Europe, Canada, US
endovascular thrombectomy (EVT), solitaire X, Standarad medical care
Dr. Michael D Hill, University of Calgary
Acute Ischemic Stroke
12/25
06/26
Menon, Bijoy
AcTQuICR, NCT03889249: Alteplase Compared to Tenecteplase in Patients With Acute Ischemic Stroke

Completed
3
1600
Canada
Tenecteplase, tNK, Alteplase, tPA
University of Calgary
Stroke, Acute, Thromboses, Intracranial
04/22
04/23
ACT-WHEN, NCT06320431: ACT-GLOBAL THROMBOLYSIS (-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632

Recruiting
3
4000
Canada, RoW
Tenecteplase, TNKase, Metalyse
University of Calgary, The George Institute for Global Health, Australia
Acute Ischemic Stroke AIS, Stroke Acute, Stroke, Acute, Stroke Ischemic
09/30
12/30
ACT-GLOBAL, NCT06352632: Adaptive Platform Trial for Stroke

Recruiting
3
20000
Canada, RoW
Standard-dose intravenous tenecteplase, Low-dose intravenous tenecteplase, No intravenous tenecteplase, Conservative Blood Pressure Control, Moderate Blood Pressure Control, Intensive Blood Pressure Control, Placebo, NoNO-42, No deferoxamine mesylate and no colchicine, Deferoxamine mesylate only, Colchicine only, Both deferoxamine mesylate and colchicine
The George Institute, University of Calgary, Berry Consultants
Stroke
09/34
09/34
NCT06403267: NoNO-42 Trial in Acute Ischemic Stroke Patients Selected for Thrombolysis with or Without Endovascular Thrombectomy

Recruiting
2
600
Canada
NoNO-42, Placebo, Control
NoNO Inc.
Acute Ischemic Stroke
05/26
05/26
SCORE, NCT05300737: Symptomatic Carotid Outcomes Registry

Recruiting
N/A
114
Canada, US
intensive medical therapy
University of Maryland, Baltimore
Carotid Stenosis, Ischemic Stroke, Transient Ischemic Attack
04/25
10/25
Investigator, STRIVE
STRIVE, NCT03335839: Adjunctive, Low-dose tPA in Primary PCI for STEMI

Active, not recruiting
3
210
Canada
tissue plasminogen activator, Saline
Population Health Research Institute, Heart and Stroke Foundation of Canada
Myocardial Infarction, Percutaneous Coronary Intervention
09/24
10/24
Parhar, Ken
FISSH, NCT03677102: Fluids in Septic Shock

Recruiting
2/3
1096
Canada, RoW
higher chloride crystalloid, lower chloride crystalloid
McMaster University, The Physicians' Services Incorporated Foundation, Canadian Institutes of Health Research (CIHR)
Sepsis, Septic Shock
11/25
03/26
TheraPPP, NCT04070053: Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning () Pathway

Completed
N/A
920
Canada
TheraPPP Pathway
University of Calgary, Alberta Health services
Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure, ARDS, Human
03/21
03/22
NCT04744298: Identification and Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning Pathway

Active, not recruiting
N/A
19916
Canada
TheraPPP
University of Calgary, Alberta Health services
Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure, ARDS, Human
03/24
10/25
HONOUR, NCT05078034: HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT

Recruiting
N/A
200
Canada
Helmet Non-Invasive Ventilation (HNIV), HNIV, High Flow Nasal Oxygen, HFNO
Sunnybrook Health Sciences Centre
Acute Hypoxemic Respiratory Failure
02/25
02/25
Save, Supriya
ESCAPE-MeVO, NCT05151172: EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions ( Trial)

Active, not recruiting
N/A
530
Europe, Canada, US
endovascular thrombectomy (EVT), solitaire X, Standarad medical care
Dr. Michael D Hill, University of Calgary
Acute Ischemic Stroke
12/25
06/26
Ebersole, Koji
NECC, NCT04852783: US IDE Study of the Contour NEurovasCular System™ for IntraCranial Aneurysm Repair

Active, not recruiting
4
250
US
Contour Neurovascular System
Cerus Endovascular, Inc.
Aneurysm, Intracranial
12/25
12/29
STEM, NCT04410146: The SQUID Trial for the Embolization of the Middle Meningeal Artery for Treatment of Chronic Subdural Hematoma

Completed
N/A
310
Europe, US
SQUID Embolization, SQUID Embolization and Surgical Evacuation, Surgical Evacuation, Other: Medical Management
Balt USA, Balt Extrusion, Embo-Flüssigkeiten A.G., AXIOM Real Time Metrics
Subdural Hematoma, Chronic
02/24
05/24
NCT05232838: US Pilot Study of the CereVasc® EShunt® System in Normal Pressure Hydrocephalus

Recruiting
N/A
50
US
eShunt Implant
CereVasc Inc, AlvaMed, Inc., Simplified Clinical Data Systems, LLC
Hydrocephalus, Normal Pressure, Hydrocephalus
01/25
01/30
CHESS, NCT06347796: Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study

Recruiting
N/A
520
US
Conventional Surgery, Middle Meningeal Artery Embolization (MMAE)
The University of Texas Medical Branch, Galveston, National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Subdural Hematoma
09/28
09/28
WEB PAS, NCT04839705: Post Approval Study - Evaluate the Long-Term Safety and Effectiveness of the WEB Device

Recruiting
N/A
180
US
WEB
Microvention-Terumo, Inc.
Wide Neck Bifurcation Intracranial Aneurysms
12/25
12/29
ESCAPE-MeVO, NCT05151172: EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions ( Trial)

Active, not recruiting
N/A
530
Europe, Canada, US
endovascular thrombectomy (EVT), solitaire X, Standarad medical care
Dr. Michael D Hill, University of Calgary
Acute Ischemic Stroke
12/25
06/26
NCT04057352: Citadel Embolization Device Study

Recruiting
N/A
150
US
Citadel Embolization Device
Stryker Neurovascular
Unruptured Wide-neck Aneurysms
06/26
06/26
NCT05409989: MicroVention, Inc. Flow Re-Direction Endoluminal Device X (FRED™ X™) Post-Approval Study

Recruiting
N/A
154
US
FRED™ X™, Flow Re-Direction Endoluminal Device X
Microvention-Terumo, Inc.
Intracranial Aneurysm
09/29
11/29
Hagan, Lois
FISSH, NCT03677102: Fluids in Septic Shock

Recruiting
2/3
1096
Canada, RoW
higher chloride crystalloid, lower chloride crystalloid
McMaster University, The Physicians' Services Incorporated Foundation, Canadian Institutes of Health Research (CIHR)
Sepsis, Septic Shock
11/25
03/26

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