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 25 Trials 
102 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Ribas, Antoni
SWOG-S1221, NCT01902173: Uprosertib, Dabrafenib, and Trametinib in Treating Patients With Stage IIIC-IV Cancer

Completed
1/2
27
US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Dabrafenib Mesylate, Dabrafenib Methanesulfonate, GSK2118436 Methane Sulfonate Salt, GSK2118436B, Tafinlar, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Trametinib Dimethyl Sulfoxide, Mekinist, Meqsel, Spexotras, Uprosertib, GSK2141795, Oral Akt Inhibitor GSK2141795
National Cancer Institute (NCI), GlaxoSmithKline, Novartis Pharmaceuticals
Hematopoietic and Lymphoid Cell Neoplasm, Locally Advanced Malignant Solid Neoplasm, Locally Advanced Melanoma, Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Stage IIIC Cutaneous Melanoma AJCC v7, Stage IV Cutaneous Melanoma AJCC v6 and v7, Unresectable Malignant Solid Neoplasm, Unresectable Melanoma
05/18
12/23
NCT06322693: A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)

Recruiting
1
475
Europe, US, RoW
TSR-022, Nivolumab, TSR-042, TSR-033, Docetaxel, Pemetrexed, Cisplatin, Carboplatin
GlaxoSmithKline
Neoplasms
08/25
02/27
NCT04119024: Gene Modified Immune Cells (IL13Ralpha2 CAR T Cells) After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

Recruiting
1
18
US
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B-518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR- 138719, WR-138719, Fludarabine Phosphate, 2-F-ara-AMP, 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-, Beneflur, Fludara, SH T 586, Fludeoxyglucose F-18, 18FDG, FDG, Fludeoxyglucose (18F), fludeoxyglucose F 18, Fludeoxyglucose F18, Fluorine-18 2-Fluoro-2-deoxy-D-Glucose, Fluorodeoxyglucose F18, IL13Ralpha2-specific Hinge-optimized 4-1BB-co-stimulatory CAR/Truncated CD19-expressing Autologous TN/MEM Cells, IL13 [EQ]BBzeta/truncated CD19[t]+ Naive and Memory T Cells, IL13 [EQ]BBzeta/truncated CD19[t]+ TN/MEM Cells, IL13Ra2-specific-hinge-optimized-4-1BB-CAR/truncated CD19-expressing Autologous TN/MEM Lymphocytes, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT
Jonsson Comprehensive Cancer Center, Parker Institute for Cancer Immunotherapy, City of Hope National Medical Center, Melanoma Research Alliance, California Institute for Regenerative Medicine (CIRM)
Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Pathologic Stage IIIC Cutaneous Melanoma AJCC V8, Pathologic Stage IV Cutaneous Melanoma AJCC V8, Recurrent Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm, Uveal Melanoma, Acral Melanoma, Neuroendocrine Tumors, Paraganglioma, Pheochromocytoma, Adrenocortical Carcinoma, Pancreatic Neuroendocrine Tumor, Thyroid Cancer, Breast Cancer, Lung Adenocarcinoma, Head and Neck Squamous Cell Carcinoma
10/25
10/26
AMBER, NCT02817633: A Study of TSR-022 in Participants With Advanced Solid Tumors

Hourglass Oct 2019 - Mar 2020 : From AMBER trial
Checkmark From AMBER trial at SITC 2018 [screenshot]
Nov 2018 - Nov 2018: From AMBER trial at SITC 2018 [screenshot]
Checkmark From AMBER trial in combination with TSR-022 at SITC 2018
Nov 2018 - Nov 2018: From AMBER trial in combination with TSR-022 at SITC 2018
Recruiting
1
447
Europe, US, RoW
TSR-022, Nivolumab, TSR-042, TSR-033, Docetaxel, Pemetrexed, Cisplatin, Carboplatin
Tesaro, Inc.
Neoplasms
04/25
04/27
SGNBB228-001, NCT05571839: A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors

Recruiting
1
275
Europe, Canada, US
PF-08046049
Seagen Inc.
Cutaneous Melanoma, Non-small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Neoplasms, Mesothelioma
11/26
11/27
Hsu, Jeffrey
NCT05566379: Mindfulness in Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia

Completed
N/A
20
US
Mindfulness - Mindful Awareness Practices ( MAPs)
University of California, Los Angeles
Long COVID, Dysautonomia
07/23
07/23
Sarkisian, Catherine
MTaN, NCT04104256: Using Behavioral Economics to Reduce Low-Value Care

Completed
N/A
1045
US
Nudge #1: Alert highlighting the safety/potential harms to patients of undergoing pre-op tests, Nudge #2: Alert highlighting the financial harms to the patient experiencing pre-op tests, Nudge #3: Alert highlighting potential psychological harms to the patient of experiencing pre-op tests, Usual Care, Control
University of California, Los Angeles, RAND, National Institute on Aging (NIA)
Pre-Operative Testing for Cataract Surgery
04/23
08/23
NCT04851691: An Electronic Clinical Decision Support Tool to Reduce Low-value Antipsychotic Prescriptions

Completed
N/A
158
US
EHR CDS, Usual Care
University of California, Los Angeles, National Institute on Aging (NIA)
Alzheimer Disease, Dementia Alzheimers, Dementia of Alzheimer Type
04/23
08/23
NCT05390502: University of California Health Remote (Home) Monitoring Evaluation

Active, not recruiting
N/A
660
US
manual monitoring and general education on use, integrated monitoring and local wrap-around hypertension program
University of California, Los Angeles, University of California Office of the President- Quality and Population Health Management, University of California, Davis, University of California, San Francisco
Hypertension
12/23
06/24
Shivkumar, Kalyanam
PREVENT VT, NCT01013714: Cardiac Sympathetic Denervation for Prevention of Ventricular Tachyarrhythmias

Recruiting
3
40
US
Cardiac Sympathetic Denervation (CSD), Routine Care
University of California, Los Angeles, Oregon Health and Science University
Sudden Cardiac Death, Ventricular Tachycardia, Ventricular Fibrillation, Cardiomyopathy
08/24
08/24
NCT04387435: Optimization of VNS in Epileptic Patients to Induce Cardioprotection

Completed
N/A
1
US
A change or titration in the current or frequency settings of the VNS therapy system.
University of California, Los Angeles, National Institutes of Health (NIH)
Epilepsy, Sudden Cardiac Death
06/23
06/23
NCT04359004: A Study to Evaluate the Effect of Vagus Nerve Stimulation in Patients Undergoing VT Ablation

Completed
N/A
5
US
Vagus Nerve Stimulation (VNS)
University of California, Los Angeles, National Institutes of Health (NIH)
Arrhythmia, Ventricular Tachycardia (VT)
06/23
10/23
IVTCC, NCT04520347: 2.0: a Prospective Multicenter Ventricular Tachycardia Catheter Ablation Registry

Enrolling by invitation
N/A
10000
Europe, Canada, Japan, US, RoW
University of California, Los Angeles
Ventricular Arrhythmia, Ventricular Tachycardia, Premature Ventricular Contraction (PVC), Cardiomyopathy
12/26
11/27
Vaseghi, Marmar
PREVENT VT, NCT01013714: Cardiac Sympathetic Denervation for Prevention of Ventricular Tachyarrhythmias

Recruiting
3
40
US
Cardiac Sympathetic Denervation (CSD), Routine Care
University of California, Los Angeles, Oregon Health and Science University
Sudden Cardiac Death, Ventricular Tachycardia, Ventricular Fibrillation, Cardiomyopathy
08/24
08/24
NCT04387435: Optimization of VNS in Epileptic Patients to Induce Cardioprotection

Completed
N/A
1
US
A change or titration in the current or frequency settings of the VNS therapy system.
University of California, Los Angeles, National Institutes of Health (NIH)
Epilepsy, Sudden Cardiac Death
06/23
06/23
NCT04359004: A Study to Evaluate the Effect of Vagus Nerve Stimulation in Patients Undergoing VT Ablation

Completed
N/A
5
US
Vagus Nerve Stimulation (VNS)
University of California, Los Angeles, National Institutes of Health (NIH)
Arrhythmia, Ventricular Tachycardia (VT)
06/23
10/23
tVNS_POAF, NCT04514757: Transcutaneous (Tragus) Vagal Nerve Stimulation for Post-op Afib

Recruiting
N/A
266
US
active tVNS, sham tVNS
University of California, Los Angeles, University of Oklahoma
Atrial Fibrillation
08/24
09/24
Sigal, Felix
NCT06267560: Lp(a) Lowering Study of Pelacarsen (TQJ230) in US Black/African American and Hispanic Participants With Elevated Lp(a) and Established ASCVD

Recruiting
3
400
US
TQJ230, pelacarsen, Placebo
Novartis Pharmaceuticals
Elevated Lp(a) and Established Atherosclerotic Cardiovascular Disease
03/27
03/27
COVER DFUs, NCT05372809: Multi-Center, Prospective, Randomized Controlled Trial Evaluating SkinTE® in the Treatment of Wagner 2 DFUs

Terminated
3
42
US
SkinTE, Autologous Heterogeneous Skin Construct, Control, Standard of Care
PolarityTE, Alira Health
Diabetic Foot
02/24
02/24
PL-5, NCT06189638: Phase II Study to Evaluate Efficacy and Safety of AMP Peptide in Mild Infections of Diabetic Foot Ulcers

Active, not recruiting
2
90
US
Antimicrobial Peptide PL-5 Topical Spray and Placebo, AMP PL-5 and Placebo
Jiangsu ProteLight Pharmaceutical & Biotechnology Co., Ltd., Parexel
Diabetic Foot Ulcers
12/26
12/27
NCT05588583: A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.

Recruiting
N/A
68
US
Mepilex Up
Molnlycke Health Care AB
Wounds, Wound of Skin, Wound Leg, Wound; Foot, Diabetic Foot Ulcer, Venous Leg Ulcer
03/24
03/24
REVITA-T2Di, NCT04419779: Evaluation of the Efficacy and Safety of DMR Using the Revita® in Subjects With Inadequately Controlled Type 2 Diabetes

Recruiting
N/A
320
Europe, US
Duodenal Mucosal Resurfacing (DMR), Duodenal Mucosal Resurfacing (Sham)
Fractyl Health Inc.
Type 2 Diabetes
06/25
01/26
NCT06035536: Clinical Study Evaluating Symphony™ Versus Standard of Care in the Treatment of Non-Healing Diabetic Foot Ulcers

Recruiting
N/A
120
US
Symphony™ plus Off-loading, Wound Dressing comprising of calcium alginate Fibracol
Aroa Biosurgery Limited, Professional Education and Research Institute
Diabetic Foot, Diabetic Foot Ulcer, Foot Ulcer, Chronic Foot Ulcer
12/24
12/24
Mavericks, NCT05758545: Trial to Evaluate the Safety and Effectiveness of Treatment With COMS One Device in Subjects With Diabetic Foot Ulcers

Recruiting
N/A
450
US
COMS One device, Concurrent Optical and Magnetic Stimulation, Sham device
Piomic Medical, NAMSA
Diabetic Foot Ulcer
06/27
06/27
Roust, Lori
REVITA-T2Di, NCT04419779: Evaluation of the Efficacy and Safety of DMR Using the Revita® in Subjects With Inadequately Controlled Type 2 Diabetes

Recruiting
N/A
320
Europe, US
Duodenal Mucosal Resurfacing (DMR), Duodenal Mucosal Resurfacing (Sham)
Fractyl Health Inc.
Type 2 Diabetes
06/25
01/26
NCT04700800: Regulation of Muscle Protein Phenotype in Humans With Obesity

Recruiting
N/A
94
US
Exercise, Infusion of Amino Acids
Mayo Clinic, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
06/25
06/25
Willmott, Lyndsay
ENGOT-EN20, NCT05611931 / 2022-002540-42: Selinexor in Maintenance Therapy After Systemic Therapy for Participants with P53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

Jul 2024 - Dec 2024: Top-line data from XPORT-EC trial in participants with TP53 wild type endometrial cancer
Recruiting
3
220
Europe, Canada, US, RoW
Selinexor, KPT-330, Matching Placebo for selinexor
Karyopharm Therapeutics Inc, GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT), Belgium and Luxembourg Gynaecological Oncology Group, North Eastern German Society of Gynaecological Oncology, Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies, Spanish Research Group in Ovarian Cancer, The Central and Eastern European Gynecologic Oncology Group, Israeli Society of Gynecologic Oncology, Australia New Zealand Gynaecological Oncology Group
Endometrial Cancer
01/25
01/28
GLORIOSA, NCT05445778: Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Ovarian, Fallopian Tube, or Peritoneal Cancer

Recruiting
3
418
Europe, Canada, US, RoW
Mirvetuximab soravtansine plus Bevacizumab, MIRV, Bevacizumab
AbbVie, GOG Foundation
Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
03/27
04/29
RAMP 301, NCT06072781: A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

Recruiting
3
270
Europe, Canada, US, RoW
avutometinib, avutometinib (VS-6766), Defactinib, defactinib (VS-6063), Pegylated liposomal doxorubicin, Caelyx, Doxil, Lipodox, Paclitaxel, Nov-Onxol, Onxol, Navaplus, Taxol, Letrozole, Femara, Anastrozole, Arimidex
Verastem, Inc., GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT), Australia New Zealand Gynaecological Oncology Group
Low Grade Serous Ovarian Cancer
10/28
02/31
ZN-c3-004, NCT04814108: A Study of ZN-c3 in Women With Recurrent or Persistent Uterine Serous Carcinoma

Recruiting
2
76
Canada, US, RoW
ZN-c3, azenosertib, KP-2638
K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
Uterine Serous Carcinoma
11/24
05/25
SGNTUC-019, NCT04579380 / 2020-004873-29: Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations

Active, not recruiting
2
217
Europe, Japan, US, RoW
tucatinib, TUKYSA, ARRY-380, ONT-380, trastuzumab, Herceptin, fulvestrant, Faslodex
Seagen Inc., Seagen, Inc.
Uterine Neoplasms, Uterine Cervical Neoplasms, Biliary Tract Neoplasms, Urologic Neoplasms, Carcinoma, Non-Small-Cell Lung, HER2 Mutations Breast Neoplasms
11/23
05/25
PRECISION 1, NCT05103358: Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes

Active, not recruiting
2
120
US, RoW
nab-sirolimus, ABI-009
Aadi Bioscience, Inc.
Tumor, Tumor, Solid, Metastasis, Metastatic Cancer, Cancer, Cancer Metastatic, Tumors, Neoplasms, Neoplasm Metastasis, Solid Tumor, Advanced Solid Tumor, Advanced Cancer, Malignant Solid Tumor, Malignant Solid Neoplasm, Malignant Neoplasm, Malignant Tumor, TSC, TSC1, TSC2, Metastatic Solid Tumor, Metastatic Neoplasm
12/24
12/25
PRESERVE-004, NCT05446298: ONC-392 and Pembrolizumab in Platinum Resistant Ovarian Cancer

Active, not recruiting
2
58
US
ONC-392, A humanized anti-CTLA4 IgG1 monoclonal antibody made by OncoC4, Inc., Pembrolizumab, MK3475, Keytruda
OncoC4, Inc., Merck Sharp & Dohme LLC, GOG Foundation
Ovarian Cancer, High Grade Serous Adenocarcinoma of Ovary, Primary Peritoneal Carcinoma, Fallopian Tube Cancer
06/25
06/26
ACR-368-201, NCT05548296: A Study of ACR-368 in Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma

Recruiting
1/2
390
US
ACR-368, prexasertib, Gemcitabine, OncoSignature
Acrivon Therapeutics, GOG Foundation
Platinum-resistant Ovarian Cancer, Endometrial Adenocarcinoma, Urothelial Carcinoma
07/26
12/27
Hussain, Shaun
SKYWAY, NCT04938427 / 2021-002481-40: A Study of Soticlestat as an Add-on Therapy in Children, Teenagers, and Adults With Lennox-Gastaut Syndrome

Completed
3
270
Europe, Canada, Japan, US, RoW
Placebo, Soticlestat, TAK-935
Takeda
Lennox Gastaut Syndrome (LGS)
01/24
01/24
SKYLINE, NCT04940624 / 2021-002480-22: A Study of Soticlestat as an Add-on Therapy in Children and Young Adults With Dravet Syndrome

Completed
3
144
Europe, Canada, Japan, US, RoW
Soticlestat, TAK-935, Placebo
Takeda
Dravet Syndrome (DS)
04/24
04/24
ENDYMION 2, NCT05163314 / 2021-002482-17: A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome

Recruiting
3
400
Europe, Canada, Japan, US, RoW
Soticlestat, TAK-935
Takeda
Dravet Syndrome (DS), Lennox Gastaut Syndrome (LGS)
05/26
05/26
NCT04289467: Treatment of Refractory Infantile Spasms With Fenfluramine

Recruiting
2
10
US
Fenfluramine, Fenfluramine Hydrochloride
Children's Hospital of Orange County
Infantile Spasm
12/24
12/25
Dravet, NCT04437004: Treatment of Syndrome With Fenfluramine (Expanded Access Protocol)

Available
N/A
US
Fenfluramine, Fenfluramine Hydrochloride
University of California, Los Angeles
Dravet Syndrome
 
 
Ajijola, Olujimi A
NCT04387435: Optimization of VNS in Epileptic Patients to Induce Cardioprotection

Completed
N/A
1
US
A change or titration in the current or frequency settings of the VNS therapy system.
University of California, Los Angeles, National Institutes of Health (NIH)
Epilepsy, Sudden Cardiac Death
06/23
06/23
Rueda, Victoria
NCT03850964: Effects of Pazopanib on Hereditary Hemorrhagic Telangiectasia Related Epistaxis and Anemia (Paz)

Recruiting
2/3
70
US
Pazopanib, Votrient, Placebo oral capsule, cellulose capsule
Cure HHT, United States Department of Defense, Food and Drug Administration (FDA)
Hereditary Hemorrhagic Telangiectasia, Epistaxis, Anemia, Nosebleed, HHT
09/25
10/26
NCT05219279: MR Imaging and MR Spectroscopy of HIV

Recruiting
N/A
60
US
University of California, Los Angeles, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
HIV Infections
07/23
03/24
CHORUS, NCT06259292: Comprehensive HHT Outcomes Registry of the United States

Recruiting
N/A
10000
US
Cure HHT, Augusta University, The Cleveland Clinic, Mayo Clinic, Massachusetts General Hospital, Columbia University, Oregon Health and Science University, University of California, Los Angeles, University of California, San Francisco, University of Colorado, Denver, University of North Carolina, Chapel Hill, University of Pennsylvania, University of Texas, University of Utah, Washington University School of Medicine, Yale University, Health Resources and Services Administration (HRSA), Children's Hospital of Philadelphia
Hereditary Hemorrhagic Telangiectasia, Arteriovenous Malformations, Telangiectasia, Epistaxis, GastroIntestinal Bleeding, Cerebral Arteriovenous Malformations, Vascular Malformation
11/33
11/33
APEX-AV, NCT05318092: Evaluating the Safety and Efficacy of the AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 PE for Treatment of Acute Pulmonary Embolism

Completed
N/A
122
US
AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 PE
Angiodynamics, Inc.
Pulmonary Embolism, Acute Pulmonary Embolism
01/24
01/24
BVMN6203, NCT01158807: Cerebral Hemorrhage Risk in Hereditary Hemorrhagic Telangiectasia

Recruiting
N/A
1800
Europe, Canada, US
Unity Health Toronto, National Institute of Neurological Disorders and Stroke (NINDS)
Hereditary Hemorrhagic Telangiectasia
12/24
06/25
M
EMERALD, NCT05001737 / 2021-001577-24: Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE

Active, not recruiting
3
41
Europe, Canada, Japan, US, RoW
Emapalumab, NI-0501, emapalumab-lzsg, ATC code: L04AA39 (WHO)
Swedish Orphan Biovitrum
Macrophage Activation Syndrome, Secondary Hemophagocytic Lymphohistiocytosis, Still Disease, Systemic Lupus Erythematosus, SJIA, AOSD, MAS
06/24
09/25
HexAgon-HN, NCT06295731: INBRX-106 in Combination With Pembrolizumab in First-line PD-L1 CPS≥20 HNSCC

Recruiting
2/3
410
US
INBRX-106, Hexavalent OX40 agonist antibody, Pembrolizumab, Keytruda
Inhibrx Biosciences, Inc
Head and Neck Squamous Cell Carcinoma (HNSCC)
05/29
05/29
NCT05051722: Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer

Recruiting
2
2640
US
Tampon Collection, Vaginal Fluid, Blood Collection
Mayo Clinic
Endometrial Cancer, Cervical Cancer, Atypical Endometrial Hyperplasia, Cervical Dysplasia, Adnexal Mass, Ovarian Cancer
12/25
06/26
NCT05102006: Phase Ib/II Clinical Study of LBL-007 in Treatment of Advanced Malignant Tumors

Recruiting
1/2
200
RoW
LBL-007 Injection, LBL-007, Toripalimab Injection
Nanjing Leads Biolabs Co.,Ltd
Advanced Solid Tumor
06/25
08/25
SL03-OHD-104, NCT05275439: Phase 1 Study of Shattuck Labs (SL)-172154 in Subjects with MDS or AML

Active, not recruiting
1
160
Europe, Canada, US
SL-172154, Azacitidine, Venetoclax
Shattuck Labs, Inc.
Acute Myeloid Leukemia, Myelodysplastic Syndromes
11/24
11/24
NCT05516862: Determining the Right Acupuncture for Good Recovery Over Neuropsychiatric Trauma

Recruiting
N/A
75
US
Dragons acupuncture, Dragons acupressure, Dragons placebo
Paul Crawford
PTSD, Post Traumatic Stress Disorder, Acupuncture
10/25
10/25
NCT03568669: Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)

Recruiting
N/A
1000
US
NIH Toolbox Cognition Battery
Debra Weese-Mayer, Ann & Robert H Lurie Children's Hospital of Chicago, Seattle Children's Hospital, Children's Hospital Los Angeles, Children's Hospital of Philadelphia
Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation, CCHS, CCHS With Hirschsprung Disease, CCHS With Neural Crest Tumor, CCHS With Neuroblastoma
12/30
12/35
Bradfield, Jason S
EPS ARREST, NCT03079414: The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest

Recruiting
N/A
100
Canada, US, RoW
Invasive Electrophysiology Study
Western University, Canada, Canadian Institutes of Health Research (CIHR)
Sudden Cardiac Death
01/25
01/25
NCT04387435: Optimization of VNS in Epileptic Patients to Induce Cardioprotection

Completed
N/A
1
US
A change or titration in the current or frequency settings of the VNS therapy system.
University of California, Los Angeles, National Institutes of Health (NIH)
Epilepsy, Sudden Cardiac Death
06/23
06/23
NCT04359004: A Study to Evaluate the Effect of Vagus Nerve Stimulation in Patients Undergoing VT Ablation

Completed
N/A
5
US
Vagus Nerve Stimulation (VNS)
University of California, Los Angeles, National Institutes of Health (NIH)
Arrhythmia, Ventricular Tachycardia (VT)
06/23
10/23
TRAVERSE, NCT03946072: Transseptal vs Retrograde Aortic Ventricular Entry to Reduce Systemic Emboli

Completed
N/A
153
Canada, US
Transseptal Aortic Approach Catheter Ablation Procedure, Retrograde Aortic Approach Catheter Ablation Procedure
University of California, San Francisco
Neurocognitive Dysfunction
11/23
11/23
LESS-VT, NCT03490201: FLExAbility Sensor Enabled Substrate Targeted Ablation for the Reduction of VT Study

Completed
N/A
592
Europe, US, RoW
Market Approved RF Ablation System, FlexAbility SE Ablation Catheter
Abbott Medical Devices
Ventricular Tachycardia
04/24
04/24
IVTCC, NCT04520347: 2.0: a Prospective Multicenter Ventricular Tachycardia Catheter Ablation Registry

Enrolling by invitation
N/A
10000
Europe, Canada, Japan, US, RoW
University of California, Los Angeles
Ventricular Arrhythmia, Ventricular Tachycardia, Premature Ventricular Contraction (PVC), Cardiomyopathy
12/26
11/27
Allen, Kathryn
RAMP 301, NCT06072781: A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

Recruiting
3
270
Europe, Canada, US, RoW
avutometinib, avutometinib (VS-6766), Defactinib, defactinib (VS-6063), Pegylated liposomal doxorubicin, Caelyx, Doxil, Lipodox, Paclitaxel, Nov-Onxol, Onxol, Navaplus, Taxol, Letrozole, Femara, Anastrozole, Arimidex
Verastem, Inc., GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT), Australia New Zealand Gynaecological Oncology Group
Low Grade Serous Ovarian Cancer
10/28
02/31
OVATION 2, NCT03393884: Study of IMNN-001 (Also Known as GEN-1) With NACT for Treatment of Ovarian Cancer

Checkmark Presentation of OVATION 2 data in advanced ovarian cancer
Mar 2021 - Mar 2021: Presentation of OVATION 2 data in advanced ovarian cancer
Active, not recruiting
1/2
130
Canada, US
IMNN-001, Carboplatin, Paclitaxel
Imunon
Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
07/24
11/25
ROCC, NCT04831580: A Trial of Robotic Versus Open Hysterectomy Surgery in Cervix Cancer

Recruiting
N/A
840
Canada, US
da Vinci, open surgery
GOG Foundation, Intuitive Foundation
Cervical Cancer
08/28
08/29
Martinez, Angela
NCT04289467: Treatment of Refractory Infantile Spasms With Fenfluramine

Recruiting
2
10
US
Fenfluramine, Fenfluramine Hydrochloride
Children's Hospital of Orange County
Infantile Spasm
12/24
12/25
TSC-STEPS, NCT05104983: Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study

Recruiting
2
64
US
Sirolimus, Placebo
Darcy Krueger
Tuberous Sclerosis Complex, Epilepsy
06/25
06/26
NCT02461459: Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC)

Active, not recruiting
N/A
205
US
Boston Children's Hospital, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS), Tuberous Sclerosis Alliance, National Center for Advancing Translational Sciences (NCATS), Office of Rare Diseases (ORD), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Tuberous Sclerosis, Autism Disorder, Intellectual Disability
12/25
12/26
CANDID, NCT05373719: Observational Study in Patients With Cyclin-dependent Kinase-like 5 Deficiency Disorder

Active, not recruiting
N/A
112
Europe, Canada, US, RoW
No intervention; observational
Loulou Foundation
Cyclin-Dependent Kinase-Like 5 Deficiency Disorder
01/27
01/27
NCT05676099: TSC Biosample Repository and Natural History Database

Recruiting
N/A
5000
Canada, US
Phlebotomy, Buccal (cheek) swab, Genetic Testing, Tissue donation after routine clinical procedure
National Tuberous Sclerosis Association
Tuberous Sclerosis, Lymphangioleiomyomatosis
12/50
12/50
ICCRN, NCT05558371: International CDKL5 Clinical Research Network

Recruiting
N/A
1000
US, RoW
No intervention.
University of Colorado, Denver, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), International Foundation for CDKL5 Research
CDKL5, CDKL5 Deficiency Disorder, CDD
02/26
02/27
Ranade, Mona
APEX-AV, NCT05318092: Evaluating the Safety and Efficacy of the AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 PE for Treatment of Acute Pulmonary Embolism

Completed
N/A
122
US
AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 PE
Angiodynamics, Inc.
Pulmonary Embolism, Acute Pulmonary Embolism
01/24
01/24
Garcia-Lloret, Maria
NCT03679676: Clinical Study Using Biologics to Improve Multi OIT Outcomes (COMBINE)

Active, not recruiting
2
108
US
Omalizumab, Xolair, Dupilumab, Dupixent, Placebo
Stanford University, National Institute of Allergy and Infectious Diseases (NIAID), Food Allergy Research & Education, Harvard School of Public Health (HSPH)
Hypersensitivity, Food Allergy, Hypersensitivity, Food, Peanut Hypersensitivity, Peanut Allergy
06/25
09/25
adored, NCT05003804: Allergic Disease Onset Prevention Study

Active, not recruiting
1/2
264
US, RoW
STMC-103H, Placebo
Siolta Therapeutics, Inc.
Atopic Dermatitis, Type 1 Hypersensitivity
11/24
10/25
Sorg, Julie
NCT05419726: Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.

Recruiting
N/A
20
US
Semaglutide Injectable Product (not provided by the study)
University of California, Los Angeles
Obesity
01/25
06/25
Bari, Ausaf
NCT02747589: Feasibility of Stimulating the Visual Cortex in Blind

Active, not recruiting
N/A
5
US
Surgical device implant in brain
University of California, Los Angeles
Blindness,Acquired
12/25
12/25
NCT04387435: Optimization of VNS in Epileptic Patients to Induce Cardioprotection

Completed
N/A
1
US
A change or titration in the current or frequency settings of the VNS therapy system.
University of California, Los Angeles, National Institutes of Health (NIH)
Epilepsy, Sudden Cardiac Death
06/23
06/23
NCT04085406: DBS of the SCC for the Treatment of Medically Refractory CLBP

Recruiting
N/A
16
US
Deep Brain Stimulation of the Subgenus Cingulate Cortex
University of California, Los Angeles, National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Low-back Pain
06/26
06/26
NCT01958086: Visuomotor Prosthetic for Paralysis

Recruiting
N/A
2
US
Neural Communication System, NeuroPort Multi-Port Array
Richard A. Andersen, PhD, University of California, Los Angeles, Casa Colina Hospital and Centers for Healthcare
Quadriplegia
04/26
07/26
Ardell, Jeffrey
NCT04387435: Optimization of VNS in Epileptic Patients to Induce Cardioprotection

Completed
N/A
1
US
A change or titration in the current or frequency settings of the VNS therapy system.
University of California, Los Angeles, National Institutes of Health (NIH)
Epilepsy, Sudden Cardiac Death
06/23
06/23
Donahue, Timothy
NCT04983862: Fluorescent Imaging of Nerves With Illuminare-1 During Surgery

Recruiting
1
50
US
Illuminare-1, Karl Storz D-Light C photodynamic diagnostic (PDD)
Memorial Sloan Kettering Cancer Center, Illuminare Biotechnologies
Prostate Adenocarcinoma
10/25
10/25
PRECEDE, NCT04970056: Pancreatic Cancer Early Detection Consortium

Recruiting
N/A
10000
Europe, Canada, US, RoW
Arbor Research Collaborative for Health
Pancreas Cancer, Pancreas Cyst, Pancreatic Ductal Adenocarcinoma, Genetic Predisposition
12/30
12/30
EA2185, NCT04239573: Comparing Two Methods to Follow Patients With Pancreatic Cysts

Recruiting
N/A
4606
Canada, US, RoW
Computed Tomography, CAT, CAT scan, Computerized Axial Tomography, computerized tomography, CT, CT scan, tomography, Endoscopic Ultrasound, endosonography, EUS, Magnetic Resonance Imaging, Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR Imaging, MRI, MRI Scan, NMR Imaging, NMRI, nuclear magnetic resonance imaging, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration
ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
Pancreatic Carcinoma
07/33
07/33
Thaker, Adarsh
REVITA-T2Di, NCT04419779: Evaluation of the Efficacy and Safety of DMR Using the Revita® in Subjects With Inadequately Controlled Type 2 Diabetes

Recruiting
N/A
320
Europe, US
Duodenal Mucosal Resurfacing (DMR), Duodenal Mucosal Resurfacing (Sham)
Fractyl Health Inc.
Type 2 Diabetes
06/25
01/26
SWAT-BE, NCT05530343: Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance

Recruiting
N/A
2298
US
Seattle protocol, WATS3D brushings
University of Colorado, Denver
Barrett Esophagus, Barretts Esophagus With Dysplasia, Esophageal Adenocarcinoma
03/26
03/26
Zheng, Anna Chen
CUTIS, NCT03004326: Clinical Transcriptomics in Systemic Vasculitis

Recruiting
N/A
50
Canada, US
Peter Merkel, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Center for Advancing Translational Sciences (NCATS), Office of Rare Diseases Research (ORDR)
Cryoglobulinemic Vasculitis (CV), Drug-induced Vasculitis, Eosinophilic Granulomatosis With Polyangiitis (EGPA), IgA Vasculitis, Isolated Cutaneous Vasculitis, Granulomatosis With Polyangiitis (GPA), Microscopic Polyangiitis (MPA), Polyarteritis Nodosa (PAN), Urticarial Vasculitis, Vasculitis
12/26
12/26
REVITA-T2Di, NCT04419779: Evaluation of the Efficacy and Safety of DMR Using the Revita® in Subjects With Inadequately Controlled Type 2 Diabetes

Recruiting
N/A
320
Europe, US
Duodenal Mucosal Resurfacing (DMR), Duodenal Mucosal Resurfacing (Sham)
Fractyl Health Inc.
Type 2 Diabetes
06/25
01/26
Lin, James
SIGLEC, NCT05839041: A Multiple Dose Study of AVD-104 for Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)

Active, not recruiting
2
300
US
AVD-104, Avacincaptad
Aviceda Therapeutics, Inc.
Geographic Atrophy of the Macula, Macular Degeneration
09/25
09/26
MAGNIFY, NCT05893537: Study to Evaluate the Efficacy and Safety of Oral CT1812 in Participants with Geographic Atrophy (GA) Secondary to Dry Age-Related Macular Degeneration (AMD).

Recruiting
2
246
US
Active Comparator CT1812, Placebo Comparator
Cognition Therapeutics
Age-Related Macular Degeneration
07/27
08/27
AACRC, NCT06342440: Early Detection of Advanced Adenomas and Colorectal Cancer

Recruiting
N/A
2000
Europe, Japan, US, RoW
DENEB, DENEB (DEtection of colorectal NEoplasias in Blood)
City of Hope Medical Center
Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma, Colorectal Disorders, Colorectal Dysplasia, Colorectal Cancer Stage I, Colorectal Cancer Stage II, Colorectal Cancer Stage III, Colorectal Cancer Stage IV, Colorectal Neoplasms Malignant, Colorectal Serrated Adenocarcinoma, Colorectal Adenoma With Severe Dysplasia, Colorectal Adenoma With Mild Dysplasia, Colorectal Adenoma With Moderate Dysplasia, Colorectal Adenoma and Carcinoma 1, Colorectal Adenomatous Polyp, Colorectal Adenocarcinoma Metastatic in the Liver
12/25
12/25
PRECEDE, NCT04970056: Pancreatic Cancer Early Detection Consortium

Recruiting
N/A
10000
Europe, Canada, US, RoW
Arbor Research Collaborative for Health
Pancreas Cancer, Pancreas Cyst, Pancreatic Ductal Adenocarcinoma, Genetic Predisposition
12/30
12/30
Srikanthan, Preethi
NCT05419726: Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.

Recruiting
N/A
20
US
Semaglutide Injectable Product (not provided by the study)
University of California, Los Angeles
Obesity
01/25
06/25
Zaki, Youstina
OPAL-1, NCT05970497: A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors

Recruiting
1/2
140
US
KB707, Opdualag
Krystal Biotech, Inc.
Cancer, Melanoma Stage III, Melanoma Stage IV, Cutaneous Melanoma
07/26
07/26
Vandenbogaart, Elizabeth
NCT05566379: Mindfulness in Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia

Completed
N/A
20
US
Mindfulness - Mindful Awareness Practices ( MAPs)
University of California, Los Angeles
Long COVID, Dysautonomia
07/23
07/23
Ward, Diamond
PRECEDE, NCT04970056: Pancreatic Cancer Early Detection Consortium

Recruiting
N/A
10000
Europe, Canada, US, RoW
Arbor Research Collaborative for Health
Pancreas Cancer, Pancreas Cyst, Pancreatic Ductal Adenocarcinoma, Genetic Predisposition
12/30
12/30
Deranteriassian, Aletta
FAPI-46 PDAC, NCT05262855: Study of [68Ga]FAPI-46 PET in Patients With Pancreatic Ductal Carcinoma

Recruiting
2
60
US
[68Ga]FAPI-46
SOFIE
PDAC - Pancreatic Ductal Adenocarcinoma, FAP
12/24
12/24
18F-FAPI-74 GI, NCT05641896: Study of [18F]FAPI-74 PET in Patients With Gastrointestinal Cancers

Recruiting
2
120
US
[18F]FAPI-74 PET/CT
SOFIE
Gastrointestinal Cancers, Cholangiocarcinoma, Gastric Cancer, Colorectal Cancer, Pancreatic Ductal Adenocarcinoma, Hepatocellular Carcinoma
07/24
03/25
NCT06387173: Registry of Patients Undergoing Cryoablation for Early Stage Breast Cancer

Recruiting
N/A
100
US
Non-Interventional Study
Jonsson Comprehensive Cancer Center
Early Stage Breast Carcinoma
01/25
01/99
PRECEDE, NCT04970056: Pancreatic Cancer Early Detection Consortium

Recruiting
N/A
10000
Europe, Canada, US, RoW
Arbor Research Collaborative for Health
Pancreas Cancer, Pancreas Cyst, Pancreatic Ductal Adenocarcinoma, Genetic Predisposition
12/30
12/30
Freeby, Matthrew
REVITA-T2Di, NCT04419779: Evaluation of the Efficacy and Safety of DMR Using the Revita® in Subjects With Inadequately Controlled Type 2 Diabetes

Recruiting
N/A
320
Europe, US
Duodenal Mucosal Resurfacing (DMR), Duodenal Mucosal Resurfacing (Sham)
Fractyl Health Inc.
Type 2 Diabetes
06/25
01/26
Haeger, Kayla
CHIPS, NCT04834414: CHIlled Platelet Study ""

Recruiting
3
1000
US, RoW
Cold Stored Platelets, Room Temperature Platelets
Philip Spinella, University of Utah, University of Minnesota, Washington University School of Medicine, United States Department of Defense, University of Pittsburgh
Acute Blood Loss
03/25
04/25
MTLE, NCT05135091: FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy

Recruiting
1/2
40
US
NRTX-1001, GABA-secreting interneurons, Sham Comparator
Neurona Therapeutics, California Institute for Regenerative Medicine (CIRM)
Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis
05/25
05/26
REVITA-T2Di, NCT04419779: Evaluation of the Efficacy and Safety of DMR Using the Revita® in Subjects With Inadequately Controlled Type 2 Diabetes

Recruiting
N/A
320
Europe, US
Duodenal Mucosal Resurfacing (DMR), Duodenal Mucosal Resurfacing (Sham)
Fractyl Health Inc.
Type 2 Diabetes
06/25
01/26
Tobis, John
RELIEF, NCT04100135: GORE® CARDIOFORM Septal Occluder Migraine Clinical Study

Terminated
N/A
7
US
Actual device PFO closure, GORE® CARDIOFORM Septal Occluder, Thienopyridine (clopidogrel or prasugrel), Plavix, Effient, Sham device PFO closure
W.L.Gore & Associates
Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
08/24
08/24
 

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