| Pan, Zhenyu |
NCT06296745: Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib. |
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| Not yet recruiting | 2 | 36 | NA | Pemetrexed | Guangzhou Medical University | Leptomeningeal Metastasis | 01/26 | 03/26 | | |
NCT06462079: Sacituzumab Govitecan Combined With Head Radiotherapy for Her2-negative Breast Cancer Brain Metastases |
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| Not yet recruiting | 2 | 43 | NA | Sacituzumab Govitecan, Trodelvy, Radiotherapy | Guangzhou Medical University | Brain Metastasis | 01/27 | 07/27 | | |
NCT05289908: Intrathecal Pemetrexed for Leptomeningeal Metastasis |
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| Completed | 1/2 | 34 | RoW | Pemetrexed (1), Pemetrexed (2), Folic Acid, Vitamin B12, Dexamethasone | The First Hospital of Jilin University, Affiliated Hospital of Guangdong Medical University, Second Affiliated Hospital of Guangzhou Medical University, Guangdong 999 Brain Hospital, The Second Hospital of Hebei Medical University, Panjin Liaoyou Gem Flower Hospital, Wuxi People's Hospital, Huizhou Third People's Hospital, Guangzhou Medical University | Leptomeningeal Metastases | 03/23 | 03/24 | | |
NCT06462092: Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer |
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| Not yet recruiting | 1/2 | 34 | NA | Sacituzumab Govitecan, Trodelvy, Pemetrexed, ALIMTA | Guangzhou Medical University | Leptomeningeal Metastases | 01/27 | 06/27 | | |
NCT06462222: Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors |
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| Not yet recruiting | 1/2 | 34 | RoW | Toripalimab, pemetrexed | Guangzhou Medical University | Leptomeningeal Metastasis | 04/26 | 06/26 | | |
NCT05305885: Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis |
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| Recruiting | N/A | 100 | RoW | Pemetrexed, Radiotherapy | The First Hospital of Jilin University, The Second Hospital of Hebei Medical University, Second Affiliated Hospital of Guangzhou Medical University, The Affiliated Hospital of Guangdong Medical College, Guangdong 999 Brain Hospital, Wuxi People's Hospital, Huizhou Third People's Hospital, Guangzhou Medical University, Panjin Liaoyou Gem Flower Hospital | Leptomeningeal Metastasis | 10/23 | 07/24 | | |
NCT06304441: Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer |
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| Recruiting | N/A | 100 | RoW | Osimertinib, Pemetrexed | Guangzhou Medical University | Leptomeningeal Metastasis | 03/25 | 03/26 | | |
