United States, Tennessee St. Jude Children's Research Hospital
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7 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Karol, Seth E
APAL2020D, NCT05183035 / 2021-003212-11: Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

Recruiting
3
98
Europe, Canada, Japan, US, RoW
Fludarabine, Cytarabine, Gemtuzumab Ozogamicin, Azacitidine, Venetoclax
LLS PedAL Initiative, LLC, Princess Maxima Center for Pediatric Oncology (European Sponsor), AbbVie, Roche-Genentech, EuPAL
Acute Myeloid Leukemia
02/27
04/31
NCT06390319: Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

Recruiting
2
100
US
Dexamethasone, Decadron, Hexadrol®, Vincristine, Vincristine Sulfate, Oncovin, Daunorubicin, Daunomycin, Calaspargase pegol, ASPARLAS, Dasatinib, Sprycel®, Venetoclax, Venclexta®, Bortezomib, Velcade®, Intrathecal triple therapy (methotrexate + hydrocortisone + cytarabine), IT MHA, Cyclophosphamide, Cytoxan®, Cytarabine, Ara-C, Cytosine arabinoside, Mercaptopurine, 6-MP, Nelarabine, Arranon, Atriance, Methotrexate, Trexall®, Thioguanine, 6-thioguanine, Tabloid®
St. Jude Children's Research Hospital, AbbVie
T-cell Acute Lymphoblastic Leukemia, T-cell Lymphoma, Mixed Phenotype Acute Leukemia
12/27
12/33
NCT06533748: Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and Lymphoma

Recruiting
2
128
US
Dexamethasone, Decadron, Hexadrol®, Vincristine, Vincristine Sulfate, Oncovin, Inotuzumab, Inotuzumab ozogamicin, BESPONSA®, Blinatumomab, BLINCYTO®, Dasatinib, Sprycel®, IT MHA, Intrathecal triple therapy (methotrexate + hydrocortisone + cytarabine), Cyclophosphamide, Cytoxan®, Cytarabine, Cytosine arabinoside, Ara-C, Methotrexate, MTX, Trexall®, 6-Mercaptopurine, Mercaptopurine, 6-MP, Calaspargase, ASPARLAS, Daunorubicin, Daunomycin, Thioguanine, 6-thioguanine, Tabloid®
St. Jude Children's Research Hospital, Pfizer, Amgen
Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma
05/28
05/34
NCT05192889: Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax

Active, not recruiting
1/2
35
US
Venetoclax, Venclextra®, ABT-199, Navitoclax, ABT-263, Dexamethasone, Decadron®, Hexadrol®, Dexameth®, Vincristine, Vincristine sulfate, Oncovin®, Calaspargase Pegol, Asparlas, Dasatinib, Sprycel®, Cytarabine, Ara-C, Cytosar-U®, Blinatumomab, Blincyto®, Methotrexate, MTX, Trexall®, amethopterin, Mercaptopurine, 6-MP, Purinethol®, Cyclophosphamide, Cytoxan®, Etoposide, VP-16, Vepesid®, Leucovorin, Folinic acid, Intrathecal Triples, ITMHA, methotrexate/hydrocortisone/cytarabine, Pegaspargase, Oncaspar®, PEG-asparaginase, PEG-L-asparaginase, Erwinia asparaginase, Erwinase®, Radiation, Irradiation
St. Jude Children's Research Hospital, AbbVie
Refractory Acute Lymphoblastic Leukemia, Relapsed Acute Lymphoblastic Leukemia
06/24
03/25
NCT04501614 / 2019-002549-39: A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Terminated
1/2
11
Europe, US, RoW
Ponatinib, Chemotherapy Agents
Takeda, Takeda Development Center Americas, Inc.
Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL), Ph+ Mixed Phenotype Acute Leukemia (MPAL), Philadelphia Chromosome-Like ALL (Ph-like ALL)
12/23
07/24
CRSPA, NCT04195347: Study of CM4620 to Reduce the Severity of Pancreatitis Due to Asparaginase

Recruiting
1/2
42
US
CM4620, CM4620-IE
St. Jude Children's Research Hospital, CalciMedica, Inc.
Acute Pancreatitis
06/25
12/27
SELCLAX, NCT04898894: Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia

Recruiting
1
42
US
Venetoclax, Venclextra®, ABT-199, Selinexor, KPT-330, Cytarabine, Cytosine arabinoside, Ara-C, Cytosar®, Fludarabine, Fludara®, Fludarabine phosphate, 2-fluoro-ara-AMP, Filgrastim, G-CSF, Methotrexate, MTX, amethopterin, Trexall®, methotrexate/hydrocortisone/cytarabine, ITMHA, Intrathecal triples
St. Jude Children's Research Hospital, Karyopharm Therapeutics Inc, AbbVie, Gateway for Cancer Research
Acute Leukemia of Ambiguous Lineage in Relapse, Acute Myeloid Leukemia, in Relapse, Refractory Acute Leukemia of Ambiguous Lineage, Refractory Acute Myeloid Leukemia
07/23
06/27

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