| Debus, Juergen |
HIT-1, NCT01182779: Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base |
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| Recruiting | 3 | 319 | Europe | Carbon ion, Protons | Heidelberg University | Chordoma, Tumor, Treatment | 08/15 | 08/23 | | |
METIS, NCT02831959: Pivotal, Open-label, Randomized Study of Radiosurgery with or Without Tumor Treating Fields (TTFields) for 1-10 Brain Metastases from Non-small Cell Lung Cancer (NSCLC). |
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| Completed | 3 | 298 | Europe, Canada, US, RoW | NovoTTF-200M device, Best Standard of Care | NovoCure GmbH | Brain Metastases from Non-small Cell Lung Cancer (NSCLC) | 11/24 | 11/24 | | |
CyberChallenge, NCT05378633: The Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases? |
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| Recruiting | 2 | 190 | Europe | SRS, Whole Brain Radiotherapy | University Hospital Heidelberg | Brain Metastases, Nsclc | 02/25 | 02/26 | | |
| Recruiting | 2 | 30 | Europe | photon, surgical therapy, Chemotherapy | University Hospital Heidelberg | Esophagus Cancer, Stage I, Esophagus Cancer, Stage II | 01/26 | 04/26 | | |
Radcav, NCT05871307: Neoadjuvant vs. Intraoperative vs. Adjuvant Resection Cavity Radiotherapy of Brain Metastases |
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| Recruiting | 2 | 90 | Europe | Preoperative Radiotherapy, Intraoperative Radiation, Postoperative Radiotherapy | University Hospital Heidelberg | Brain Metastases, Radiotherapy | 05/26 | 05/28 | | |
INDIGO, NCT05964569: Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Low Grade Glioma |
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| Recruiting | 2 | 120 | Europe | model-guided optimization of treatment plan, standard treatment plan, no optimization | University Hospital Heidelberg | Low Grade Glioma | 11/26 | 11/28 | | |
ENCEPHALON, NCT03297788: Whole Brain Radiation Therapy Alone vs. Radiosurgery for SCLC Patients With 1-10 Brain Metastases |
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| Completed | N/A | 56 | Europe | SRS, WBRT | Juergen Debus, Heidelberg University | SCLC, Brain Metastases | 10/23 | 12/23 | | |
PAROS, NCT04083937: Prostate Cancer Patients Treated With Alternative Radiation Oncology Strategies |
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| Recruiting | N/A | 897 | Europe | Hypofractionated radiotherapy with photons, Hypofractionated radiotherapy with protons, Normofractionated radiotherapy with photons | University Hospital Heidelberg | Prostate Cancer | 04/28 | 01/29 | | |
NCT04613388: Registry Study of Proton Radiotherapy in Lymphoma |
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| Recruiting | N/A | 200 | Europe | Assesment of Effectiveness and side effects | University Hospital Heidelberg | Mediastinal Lymphoma | 08/25 | 08/26 | | |
PUMA, NCT05237453: Pulmonary Magnetic Resonance-guided Online Adaptive Radiotherapy of Locally Advanced Non-Small Cell Lung Cancer |
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| Recruiting | N/A | 30 | Europe | Photons | University Hospital Heidelberg, University Hospital Tuebingen, Ludwig-Maximilians - University of Munich, German Cancer Research Center | Non-small Cell Lung Cancer | 03/26 | 03/27 | | |
NAVIGATORR, NCT05671458: Multiparametric Imaging-based Intraoperative Navigation for Guidance of Surgical Resection and Postoperative Radiotherapy in Patients With Head-and-neck Tumors |
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| Recruiting | N/A | 60 | Europe | intraoperative navigation and creation of tumor resection maps | Juergen Debus | Head and Neck Tumors | 01/27 | 01/27 | | |
| Paul, Angela |
ENCEPHALON, NCT03297788: Whole Brain Radiation Therapy Alone vs. Radiosurgery for SCLC Patients With 1-10 Brain Metastases |
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| Completed | N/A | 56 | Europe | SRS, WBRT | Juergen Debus, Heidelberg University | SCLC, Brain Metastases | 10/23 | 12/23 | | |
| Rieken, Stefan |
| Recruiting | 3 | 100 | Europe | Standard, Experimental, Rituximab, Obinutuzumab | Heidelberg University | Early Stage Follicular Lymphoma WHO Grade 1/2 or 3a | 12/26 | 12/29 | | |
| Active, not recruiting | 2 | 180 | Europe | Chemotherapy, all brands of 5-fluorouracil (5-FU) are allowed, all brands of Mitomycin C (MMC) are allowed, Radiation, Durvalumab, PD-L1 inhibitor | Goethe University, German Cancer Aid, AstraZeneca | Anal Cancer, Anal Carcinoma, Anal Cancer Stage III, Anal Cancer Stage II | 12/26 | 03/27 | | |
| Recruiting | 2 | 110 | Europe | standard Radiotherapy, standard, Chemotherapy, Immunotherapy, Experimental Radiotherapy, Experimental | TheraOp, AstraZeneca | Stage III Non-small Cell Lung Cancer, Locally Advanced, Unresectable | 06/26 | 06/28 | | |
ENCEPHALON, NCT03297788: Whole Brain Radiation Therapy Alone vs. Radiosurgery for SCLC Patients With 1-10 Brain Metastases |
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| Completed | N/A | 56 | Europe | SRS, WBRT | Juergen Debus, Heidelberg University | SCLC, Brain Metastases | 10/23 | 12/23 | | |
| Bernhardt, Denise |
NCT03697343: Fractionated Stereotactic Radiotherapy vs. Single Session Radiosurgery in Patients With Larger Brain Metastases |
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| Recruiting | 3 | 382 | Europe | Radiosurgery, Fractionated stereotactic radiotherapy | University of Erlangen-Nürnberg Medical School | Cerebral Metastases of Solid Cancers | 05/26 | 05/26 | | |
NCT05112549: Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26) |
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| Recruiting | 1 | 46 | Europe | Nivolumab [Opdivo] | University Hospital Tuebingen | Leptomeningeal Disease | 09/25 | 09/26 | | |
NCT06146010: Non Interventional German Leptomeningeal Disease Register |
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| Recruiting | N/A | 50 | Europe | No intervention | University Hospital Tuebingen | Meningeal Neoplasms, Leptomeningeal Disease | 01/29 | 12/29 | | |
| Shafie, Rami El |
| Terminated | 3 | 166 | Europe, Canada, Japan, US, RoW | Xevinapant (Debio 1143), IMRT, Placebo | EMD Serono Research & Development Institute, Inc., Merck KGaA, Darmstadt, Germany | Head and Neck Cancer | 08/24 | 08/24 | | |
| Recruiting | 2 | 110 | Europe | standard Radiotherapy, standard, Chemotherapy, Immunotherapy, Experimental Radiotherapy, Experimental | TheraOp, AstraZeneca | Stage III Non-small Cell Lung Cancer, Locally Advanced, Unresectable | 06/26 | 06/28 | | |
SOCOFIN-1, NCT06278831: Efficacy of Structured SOcial COnsultation and Support in Reducing the FINancial Burden of Radiotherapy |
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| Recruiting | N/A | 225 | Europe | Questionnaire | University Medical Center Goettingen | Financial Toxicity | 05/24 | 10/24 | | |
ENCEPHALON, NCT03297788: Whole Brain Radiation Therapy Alone vs. Radiosurgery for SCLC Patients With 1-10 Brain Metastases |
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| Completed | N/A | 56 | Europe | SRS, WBRT | Juergen Debus, Heidelberg University | SCLC, Brain Metastases | 10/23 | 12/23 | | |
