| Contact, Central |
NCT03641560: A Safety and Efficacy Study of Enzalutamide in Indian Patients With Progressive Metastatic Castration-Resistant Prostate Cancer (mCRPC) Previously Treated With Docetaxel-Based Chemotherapy |
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| Completed | 4 | 52 | RoW | Enzalutamide, MDV3100, Xtandi, Androgen deprivation therapy (ADT) | Astellas Pharma Inc | Metastatic Castration Resistant Prostate Cancer | 02/24 | 02/24 | | |
| Recruiting | 4 | 30 | US | IgPro10, Privigen | CSL Behring | Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) | 12/29 | 12/29 | | |
NCT02294461: An Asian Study to Evaluate Efficacy and Safety of Oral Enzalutamide in Progressive Metastatic Prostate Cancer Participants |
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| Completed | 3 | 395 | RoW | Enzalutamide, Xtandi, MDV3100, Placebo | Astellas Pharma Inc | Progressive Metastatic Prostate Cancer | 09/15 | 07/24 | | |
NCT06524739: Double-blind, Randomized, Placebo-controlled Study Evaluating Efficacy and Safety of IgPro20 in Post-COVID-19 POTS |
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| Recruiting | 3 | 177 | Canada, US | IgPro20, HIZENTRA®, Placebo | CSL Behring | Post-COVID Postural Orthostatic Tachycardia Syndrome | 09/27 | 09/27 | | |
NCT06617897: Phase 3 Study of Fibrinogen Concentrate (CSL511) in Subjects With Pseudomyxoma Peritonei Undergoing Cytoreductive Surgery |
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| Recruiting | 3 | 90 | Europe | CSL511 Fibrinogen concentrate (human), Cryoprecipitate | CSL Behring | Acquired Fibrinogen Deficiency | 09/26 | 10/26 | | |
TAP, NCT05568888: Evaluation of BE1116 in Patients With Traumatic Injury and Acute Major Bleeding to Improve Survival ( Study ) |
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| Terminated | 3 | 1370 | Europe, US, RoW | BE1116, 4-Factor Prothrombin Complex, Kcentra®, Beriplex®, Placebo | CSL Behring | Traumatic Injury | 10/24 | 10/24 | | |
NCT02439268: The Safety and Efficacy Study of Vemurafenib (CT) Compared With Vemurafenib (Zelbolaf®) in Advanced Patients Harboring the V600 BRAF Mutation |
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| Active, not recruiting | 2 | 100 | RoW | Vemurafenib, Zelboraf, Vemurafenib (CT), RO5185426, PLX4032 | Cancer Centre of Monoclonal Therapy, LLC, The European Association for Cancer Research, Melanoma Research Foundation, Alliance for Clinical Trials in Oncology in EU | Colorectal Cancer, Recurrent/Refractory BRAFV600E-mutant Gliomas, Advanced Cancers, Melanoma, Advanced BRAF-mutant Cancers | 07/15 | 05/18 | | |
NCT02430220: The Safety and Efficacy Study of Regorafenib (CT) Compared With Regorafenib (STIVARGA) in Patients With Solid Tumors |
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| Active, not recruiting | 2 | 152 | RoW | Regorafenib (CT), BAY 73-4506, Regorafenib (STIVARGA) | Cancer Centre of Monoclonal Therapy, LLC, Clinical Cancer Hospital, Bayer | Solid Tumors, Colorectal Cancer | 04/18 | 09/18 | | |
| Active, not recruiting | 2 | 100 | US | ALG-055009, Placebo | Aligos Therapeutics | NASH, MASH, Metabolic Dysfunction-Associated Steatohepatitis, Nonalcoholic Steatohepatitis | 11/24 | 12/24 | | |
NCT06545916: Study of Sunobinop on Alcohol Consumption in Alcohol Use Disorder |
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| Recruiting | 2 | 200 | US | Sunobinop, V117957, Placebo to match sunobinop | Imbrium Therapeutics, Purdue Pharma LP | Alcohol Use Disorder | 07/25 | 07/25 | | |
NCT06285214: Study of V117957 in Interstitial Cystitis/Bladder Pain Syndrome |
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| Completed | 1 | 47 | US | V117957, Placebo | Imbrium Therapeutics, Purdue Pharma LP | Interstitial Cystitis/Bladder Pain Syndrome | 01/25 | 01/25 | | |
NCT04285827: Safety of Single Doses of CSL889 in Adult Patients With Sickle Cell Disease |
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| Completed | 1 | 28 | Europe, US | CSL889 | CSL Behring | Sickle Cell Disease | 07/23 | 07/23 | | |
NCT03426254: Comparison of Safety and Clinical Benefit of Injections Subcutaneously Talazoparib Versus Oral Talazoparib in Patients With Solid Tumors |
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| Withdrawn | 1 | 10 | RoW | Injections Subcutaneously Talazoparib, MDV3800, BMN673, Oral capsules Talazoparib | Center Trials & Treatment, BioGene Pharmaceutical | Advanced or Recurrent Solid Tumors, Breast Neoplasm | 12/23 | 01/24 | | |
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| Recruiting | 1 | 174 | US | PRL-02 injection, prednisone, dexamethasone, enzalutamide | Astellas Pharma Global Development, Inc. | Prostate Cancer, Metastatic Castration Resistant Prostate Cancer, Metastatic Castration-sensitive Prostate Cancer | 08/25 | 05/29 | | |
NCT06364696: A Study to Find a Suitable Dose of ASP4396 in Adults With Solid Tumors |
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| Recruiting | 1 | 175 | US | ASP4396 | Astellas Pharma Inc | Solid Tumor | 04/27 | 04/27 | | |
| Recruiting | 1 | 229 | US | ASP1012, Pembrolizumab | Astellas Pharma Global Development, Inc. | Solid Tumor | 06/29 | 06/29 | | |
NCT06248086: A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell Lymphomas |
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| Terminated | 1 | 1 | RoW | ASP2802, MACT, MA-20, ASP101G, MicAbody | Astellas Pharma Global Development, Inc. | B-cell Lymphoma | 12/24 | 12/24 | | |
NCT06024642: Study of V117957 in Overactive Bladder Syndrome |
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| Completed | 1 | 51 | US | V117957, Placebo | Imbrium Therapeutics, Purdue Pharma LP | Overactive Bladder Syndrome | 05/24 | 05/24 | | |
| Completed | N/A | 1443 | US | | Shire | Hunter Syndrome | 02/23 | 02/23 | | |
NCT05104840: A Randomized Study to Determine the Expression of the Furin Protein in Patients With SARS-CoV-2 and Vaccinated Against Coronavirus |
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| Terminated | N/A | 2432 | US, RoW | | Center Trials & Treatment, Oleg Martynenko | COVID-19, SARS-CoV-2, Furin, RGMc Processing, Paired Basic Amino Acid Cleaving Enzyme (PACE) | 03/23 | 03/23 | | |
| Recruiting | N/A | 1257 | US | | Shire | Gaucher Disease | 09/25 | 09/25 | | |
NCT06734585: Using Gilteritinib to Keep People With Acute Myeloid Leukemia Cancer-free After a Stem Cell Transplant |
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| Recruiting | N/A | 200 | RoW | Gilteritinib, ASP2215, XOSPATA® | Astellas Pharma Singapore Pte. Ltd. | Acute Myeloid Leukemia | 06/25 | 06/25 | | |
OPTION-VMS, NCT06049797: A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats |
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| Recruiting | N/A | 1000 | US | Fezolinetant, ESN364, VEOZAH, Paroxetine, Citalopram, Escitalopram, Desvenlafaxine, Venlafaxine, Gabapentin, Clonidine, Pregabalin, Oxybutynin, Any other SSRI/SNRI not already specified, Any other non-hormonal pharmacologic therapy prescribed for the treatment of VMS not included in a category above | Astellas Pharma Global Development, Inc. | Hot Flashes | 02/26 | 11/26 | | |
NCT03971253: Japan Post-Marketing Surveillance for Peficitinib to Assess Safety and Effectiveness in the Patients With Rheumatoid Arthritis |
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| Recruiting | N/A | 3000 | Japan | Peficitinib, ASP015K, Smyraf | Astellas Pharma Inc | Rheumatoid Arthritis (RA) | 12/25 | 12/25 | | |
NCT05886348: The Evaluation of Safety and Myopia Progression Control Using Novel Spectacle Lens |
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| Active, not recruiting | N/A | 249 | RoW | Model-A Novel spectacle lens, Model-B Novel spectacle lens, Single vision spectacle lens | HOYA Lens Thailand LTD. | Myopia | 05/26 | 05/27 | | |
NCT06011954: A Study to Survey Adults in South Korea With Cancer Who Receive PADCEV Injection |
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| Recruiting | N/A | 202 | RoW | Enfortumab Vedotin, PADCEV, ASG-22CE | Astellas Pharma Korea, Inc., Seagen Inc. | Urothelial Cancer | 07/27 | 07/27 | | |
| Recruiting | N/A | 350 | US | Veye Lung nodules | Aidence | Lung; Node | 07/21 | 07/21 | | |
| Napolitano |
JOIN-us, NCT05856266: An 18-month Low-interventional Study to Assess Joint Health in Haemophilia A and B Patients on Prophylaxis With Efmoroctocog Alfa or Eftrenonacog Alfa |
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| Terminated | 4 | 10 | Europe, RoW | Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US), Haemophilia Joint Health Score (HJHS) | Swedish Orphan Biovitrum, IQVIA Pvt. Ltd | Hemophilia A, Hemophilia B | 12/23 | 12/23 | | |
| Sacco, Simona |
| Not yet recruiting | 2 | 118 | Europe | HEAD DOWN TILT -10° to -15° | University of Milano Bicocca, Fondazione IRCCS San Gerardo dei Tintori, Azienda Ospedaliero-Universitaria Careggi, Firenze, Azienda Ospedaliera Universitaria Gaetano Martino, Messina, Azienda Ospedaliero Universitaria, Santa Maria della Misericordia di Udine, Italy, Università degli Studi dell'Aquila, Azienda Ospedaliero Universitaria Policlinico Umberto I, Roma | Acute Ischemic Stroke | 09/26 | 12/26 | | |
NCT05161871: Transcranial Direct Current Stimulation Plus Monoclonal Antibodies Acting on the CGRP Pathway for Migraine |
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| Completed | N/A | 30 | Europe | Cathodal transcranial direct current stimulation, Sham cathodal transcranial direct current stimulation | University of L'Aquila | Migraine | 01/23 | 04/23 | | |
| Completed | N/A | 2239 | Europe | Aspirin, B01AC06, acetylsalicylic acid, Clopidogrel, B01AC04, Ticagrelor, B01AC24 | University of L'Aquila | Ischemic Stroke, TIA | 02/23 | 05/23 | | |
BACH, NCT06537700: OnaBotulinumtoxin-A in Chronic Migraine Patients with Short or Long Disease History (the Study) |
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| Recruiting | N/A | 115 | Europe | OnabotulinumtoxinA OBT-A | Fondazione Policlinico Universitario Campus Bio-Medico | Migraine | 12/24 | 12/25 | | |
TRICS-9, NCT04400981: Clinical Trial on Remote Ischemic Conditioning in Acute Ischemic Stroke Within 9 Hours of Onset in Patients Ineligible to Recanalization Therapies |
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| Completed | N/A | 80 | Europe | Remote ischemic conditioning, standard medical therapy | University of Milano Bicocca, San Gerardo Hospital, Università degli Studi dell'Aquila, University of Roma La Sapienza, IRCCS Fondazione Istituto Neurologico Mondino Pavia, Istituto Di Ricerche Farmacologiche Mario Negri | Ischemic Stroke | 04/24 | 08/24 | | |
NCT05843721: Post-marketing Clinical Follow-up for Long-term Use of Intranasal Kinetic Oscillation in Subjects with Chronic Migraine |
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| Recruiting | N/A | 200 | Europe, RoW | KOS (Intranasal kinetic oscillation stimulation) | Chordate Medical | Chronic Migraine | 03/25 | 03/26 | | |
| Not yet recruiting | N/A | 300 | Europe | Portable low-field MRI | University of L'Aquila | Stroke, Ischemic Stroke, Hemorrhagic Stroke, Magnetic Resonance Imaging | 09/26 | 11/26 | | |
| Bertolaccini, Luca |
NCT05230420: Urine Bag Usage Versus Chest Drain Clamping After Lung Resection Surgeries |
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| Recruiting | N/A | 160 | Europe, RoW | Clamping, Urine bag | Al-Quds University, Assiut University, Tanta University, European Institute of Oncology | Pneumothorax and Air Leak, Pneumothorax, Pleura Injury, Pleural Effusion | 11/22 | 12/22 | | |
| Enrolling by invitation | N/A | 1000 | Europe | | The Mediterranean Institute for Transplantation and Advanced Specialized Therapies, S. Andrea Hospital, Azienda Policlinico Umberto I, Azienda Ospedaliero, Universitaria Pisana, Università degli Studi dell'Aquila, University of Milan, Azienda Ospedaliera di Perugia, Monaldi Hospital, Azienda Ospedaliera di Bolzano, AUSL Romagna Rimini, European Institute of Oncology, Università degli Studi di Ferrara, Azienda Socio Sanitaria Territoriale di Mantova | Lung Cancer | 03/28 | 03/28 | | |
| D'Amario, Maurizio |
NCT05853523: The Desensitizing Treatment Effects of the Laser and Ozone on Dentin Hypersensitivity: In-vivo Comparison |
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| Completed | 2 | 44 | Europe | Gas ozone, Diode laser and desensitized gel | University of L'Aquila | Dentin Sensitivity | 02/22 | 08/22 | | |
| Crisci, Roberto |
| Enrolling by invitation | N/A | 1000 | Europe | | The Mediterranean Institute for Transplantation and Advanced Specialized Therapies, S. Andrea Hospital, Azienda Policlinico Umberto I, Azienda Ospedaliero, Universitaria Pisana, Università degli Studi dell'Aquila, University of Milan, Azienda Ospedaliera di Perugia, Monaldi Hospital, Azienda Ospedaliera di Bolzano, AUSL Romagna Rimini, European Institute of Oncology, Università degli Studi di Ferrara, Azienda Socio Sanitaria Territoriale di Mantova | Lung Cancer | 03/28 | 03/28 | | |
| Bertani, Alessandro |
| Enrolling by invitation | N/A | 1000 | Europe | | The Mediterranean Institute for Transplantation and Advanced Specialized Therapies, S. Andrea Hospital, Azienda Policlinico Umberto I, Azienda Ospedaliero, Universitaria Pisana, Università degli Studi dell'Aquila, University of Milan, Azienda Ospedaliera di Perugia, Monaldi Hospital, Azienda Ospedaliera di Bolzano, AUSL Romagna Rimini, European Institute of Oncology, Università degli Studi di Ferrara, Azienda Socio Sanitaria Territoriale di Mantova | Lung Cancer | 03/28 | 03/28 | | |
| Mattei, Antonella |
| Recruiting | N/A | 72000 | Europe | Hospitalization | University of L'Aquila, GlaxoSmithKline | Herpes Zoster, Comorbidities and Coexisting Conditions | 04/24 | 07/25 | | |
| Fiasca, Fabiana |
| Recruiting | N/A | 72000 | Europe | Hospitalization | University of L'Aquila, GlaxoSmithKline | Herpes Zoster, Comorbidities and Coexisting Conditions | 04/24 | 07/25 | | |
| Gabutti, Giovanni |
| Recruiting | N/A | 72000 | Europe | Hospitalization | University of L'Aquila, GlaxoSmithKline | Herpes Zoster, Comorbidities and Coexisting Conditions | 04/24 | 07/25 | | |
| Fabiani, Leila |
| Recruiting | N/A | 72000 | Europe | Hospitalization | University of L'Aquila, GlaxoSmithKline | Herpes Zoster, Comorbidities and Coexisting Conditions | 04/24 | 07/25 | | |
| Tepedino, Michele |
NCT06283823: Morphological Changes of Removable Orthodontic Retainers During the Use |
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| Recruiting | N/A | 36 | Europe | Thermoformed orthodontic retainer | University of L'Aquila | Orthodontic Retainer | 04/24 | 12/24 | | |
