| Boockvar, John |
NCT04937244: Pilot Study Evaluating the Optimization of the ORBEYE Blue Light Filter During Fluorescence-Guided Resection of Gliomas |
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| Recruiting | 4 | 10 | US | 5ALA exoscopic fluorescence filter | Northwell Health, Olympus Corporation | Malignant Glioma of Brain | 05/22 | 05/22 | | |
| Active, not recruiting | 3 | 314 | Europe, Canada, US, RoW | Standard surgery, Intraoperative radiotherapy, IORT, Radiochemotherapy, Temozolomide | Universitätsmedizin Mannheim, Carl Zeiss Meditec AG, University of California, Los Angeles | Glioblastoma | 06/24 | 06/26 | | |
| Recruiting | 3 | 450 | Europe, Canada, Japan, US, RoW | Dordaviprone (ONC201), Dordaviprone (ONC201) + Placebo, Placebo | Chimerix | H3 K27M, Glioma | 08/26 | 08/26 | | |
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NCT05271240: Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM |
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| Recruiting | 3 | 432 | US | Repeated Superselective Intraarterial Cerebral infusion (SIACI) of Bevacizumab (Avastin) with Temozolomide and Radiation, IA BV+TMZ/RT, Intraarterial Bevacizumab, Temozolomide and Radiation Alone, TMZ/RT alone | Northwell Health | Glioblastoma, Glioblastoma Multiforme, Glioma, Malignant, GBM, Brain Cancer, Glioblastoma, IDH-wildtype, Glioblastoma Multiforme, Adult | 04/27 | 04/28 | | |
| Active, not recruiting | 2 | 247 | US | SurVaxM | MimiVax, LLC, Translational Drug Development, Merit | Newly Diagnosed Glioblastoma | 08/24 | 08/24 | | |
| Active, not recruiting | 2 | 30 | US | Azeliragon | Cantex Pharmaceuticals, Medpace, Inc. | Glioblastoma | 09/24 | 06/25 | | |
ImmuneSense, NCT04485949: A Phase 2b Clinical Study With a Combination Immunotherapy in Newly Diagnosed Patients With Glioblastoma |
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| Active, not recruiting | 2 | 93 | US | IGV-001 Cell Immunotherapy, Placebo, Standard of Care (SOC): Radiation Therapy, SOC: Temozolomide | Imvax | Glioblastoma | 01/25 | 07/27 | | |
NCT02800486: Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA |
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| Recruiting | 2 | 37 | US | Intra-arterial Cetuximab, Intra-arterial Mannitol, Hypofractionated re-irradiation | Northwell Health | Glioblastoma, Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma, Glioma, Brain Neoplasm, Brain Cancer, Brain Tumor, Brain Tumor, Recurrent, Brain Neoplasm, Malignant | 05/25 | 05/26 | | |
NCT01811498: Repeated Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Newly Diagnosed GBM |
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| Completed | 1/2 | 31 | US | Bevacizumab, Avastin | Northwell Health, Feinstein Institute for Medical Research | Glioblastoma Multiforme, Brain Tumor | 08/21 | 10/21 | | |
NCT01269853: Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA |
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| Recruiting | 1/2 | 54 | US | Bevacizumab | Northwell Health, Feinstein Institute for Medical Research | Glioblastoma Multiforme, Anaplastic Astrocytoma | 10/25 | 10/26 | | |
NCT02861898: Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma |
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| Recruiting | 1/2 | 33 | US | Intra-arterial Cetuximab, Intra-arterial Mannitol | Northwell Health | Glioblastoma, Brain Cancer, Brain Neoplasm, Brain Tumor, Brain Neoplasm, Malignant, EGFR Gene Overexpression, GBM | 12/25 | 12/26 | | |
| Recruiting | 1/2 | 67 | US | Capecitabine, Xeloda, Temozolomide, Temodar | Northwell Health | Glioblastoma Multiforme (GBM), Glioblastoma, Glioma of Brain, Glioblastoma, Adult, Brain Tumor, Brain Tumor, Primary, Brain Tumor Adult, Cancer, Brain Cancer | 06/26 | 06/26 | | |
FRONTIER, NCT05303467: A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM |
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| Active, not recruiting | 1 | 12 | US | TheraSphere GBM, TheraSphere™ GBM Y-90 Glass Microspheres (TheraSphere GBM) | Boston Scientific Corporation | Glioblastoma Multiforme, Recurrent Glioblastoma | 12/24 | 06/25 | | |
NCT04222309: Laparoscopically Harvested Omental Free Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Recurrent Glioblastoma Multiforme (rGBM) |
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| Suspended | 1 | 10 | US | Laparoscopically harvested omental free flap | Northwell Health | Glioma, Glioma, Malignant, Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme of Brain, GBM, Brain Cancer | 01/25 | 01/26 | | |
| Available | N/A | | US | Gallium Maltolate, GaM | Imaging Biometrics, LLC, xCures | Glioblastoma, Refractory Glioblastoma, Glioblastoma Multiforme | | | | |
NCT03630289: Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM |
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| Active, not recruiting | N/A | 12 | US | Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB), surgical tissue flap, tissue autograft | Northwell Health | Glioblastoma, Glioblastoma Multiforme, GBM, Brain Cancer | 05/23 | 12/26 | | |
NCT05979064: Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM) |
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| Recruiting | N/A | 10 | US | Laparoscopically harvested omental tissue autograft | Northwell Health | Glioma, Glioma, Malignant, Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme of Brain, GBM, Brain Cancer, High Grade Glioma | 04/25 | 04/27 | | |
NCT05954858: Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma |
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| Recruiting | N/A | 32 | US | Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB), surgical tissue flap, tissue autograft | Northwell Health | Glioma, Malignant, Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme, Adult, High Grade Glioma, GBM, Brain Cancer | 06/26 | 06/27 | | |
| Wong, Tamika |
| Active, not recruiting | 3 | 314 | Europe, Canada, US, RoW | Standard surgery, Intraoperative radiotherapy, IORT, Radiochemotherapy, Temozolomide | Universitätsmedizin Mannheim, Carl Zeiss Meditec AG, University of California, Los Angeles | Glioblastoma | 06/24 | 06/26 | | |
NCT05271240: Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM |
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| Recruiting | 3 | 432 | US | Repeated Superselective Intraarterial Cerebral infusion (SIACI) of Bevacizumab (Avastin) with Temozolomide and Radiation, IA BV+TMZ/RT, Intraarterial Bevacizumab, Temozolomide and Radiation Alone, TMZ/RT alone | Northwell Health | Glioblastoma, Glioblastoma Multiforme, Glioma, Malignant, GBM, Brain Cancer, Glioblastoma, IDH-wildtype, Glioblastoma Multiforme, Adult | 04/27 | 04/28 | | |
| Active, not recruiting | 2 | 247 | US | SurVaxM | MimiVax, LLC, Translational Drug Development, Merit | Newly Diagnosed Glioblastoma | 08/24 | 08/24 | | |
| Active, not recruiting | 2 | 30 | US | Azeliragon | Cantex Pharmaceuticals, Medpace, Inc. | Glioblastoma | 09/24 | 06/25 | | |
NCT02800486: Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA |
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| Recruiting | 2 | 37 | US | Intra-arterial Cetuximab, Intra-arterial Mannitol, Hypofractionated re-irradiation | Northwell Health | Glioblastoma, Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma, Glioma, Brain Neoplasm, Brain Cancer, Brain Tumor, Brain Tumor, Recurrent, Brain Neoplasm, Malignant | 05/25 | 05/26 | | |
NCT01269853: Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA |
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| Recruiting | 1/2 | 54 | US | Bevacizumab | Northwell Health, Feinstein Institute for Medical Research | Glioblastoma Multiforme, Anaplastic Astrocytoma | 10/25 | 10/26 | | |
NCT02861898: Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma |
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| Recruiting | 1/2 | 33 | US | Intra-arterial Cetuximab, Intra-arterial Mannitol | Northwell Health | Glioblastoma, Brain Cancer, Brain Neoplasm, Brain Tumor, Brain Neoplasm, Malignant, EGFR Gene Overexpression, GBM | 12/25 | 12/26 | | |
| Recruiting | 1/2 | 67 | US | Capecitabine, Xeloda, Temozolomide, Temodar | Northwell Health | Glioblastoma Multiforme (GBM), Glioblastoma, Glioma of Brain, Glioblastoma, Adult, Brain Tumor, Brain Tumor, Primary, Brain Tumor Adult, Cancer, Brain Cancer | 06/26 | 06/26 | | |
FRONTIER, NCT05303467: A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM |
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| Active, not recruiting | 1 | 12 | US | TheraSphere GBM, TheraSphere™ GBM Y-90 Glass Microspheres (TheraSphere GBM) | Boston Scientific Corporation | Glioblastoma Multiforme, Recurrent Glioblastoma | 12/24 | 06/25 | | |
NCT04222309: Laparoscopically Harvested Omental Free Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Recurrent Glioblastoma Multiforme (rGBM) |
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| Suspended | 1 | 10 | US | Laparoscopically harvested omental free flap | Northwell Health | Glioma, Glioma, Malignant, Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme of Brain, GBM, Brain Cancer | 01/25 | 01/26 | | |
| Available | N/A | | US | Gallium Maltolate, GaM | Imaging Biometrics, LLC, xCures | Glioblastoma, Refractory Glioblastoma, Glioblastoma Multiforme | | | | |
NCT03630289: Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM |
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| Active, not recruiting | N/A | 12 | US | Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB), surgical tissue flap, tissue autograft | Northwell Health | Glioblastoma, Glioblastoma Multiforme, GBM, Brain Cancer | 05/23 | 12/26 | | |
NCT05979064: Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM) |
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| Recruiting | N/A | 10 | US | Laparoscopically harvested omental tissue autograft | Northwell Health | Glioma, Glioma, Malignant, Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme of Brain, GBM, Brain Cancer, High Grade Glioma | 04/25 | 04/27 | | |
NCT05954858: Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma |
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| Recruiting | N/A | 32 | US | Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB), surgical tissue flap, tissue autograft | Northwell Health | Glioma, Malignant, Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme, Adult, High Grade Glioma, GBM, Brain Cancer | 06/26 | 06/27 | | |
NCT06097845: Transcranial Ultrasound Via Sonolucent Cranioplasty |
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| Recruiting | N/A | 50 | US | Transcranial Ultrasound | Northwell Health | Cranioplasty, Sonolucent Cranioplasty, Reconstructive Cranioplasty | 08/25 | 08/26 | | |
