Methodist Hospital Trials

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Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

Shaughnessy, Paul

FELIX, NCT04404660: A Study of CD19 Targeted CAR T Cell Therapy in Adult Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL)

Active, not recruiting

1/2

153

Europe, US

AUTO1, Obecabtagene autoleucel (obe-cel)

Autolus Limited

Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia

05/25

CARBON, NCT04035434: A Safety and Efficacy Study Evaluating CTX110 in Subjects With Relapsed or Refractory B-Cell Malignancies

Active, not recruiting

1/2

227

Europe, Canada, US, RoW

CTX110

CRISPR Therapeutics AG

B-cell Malignancy, Non-Hodgkin Lymphoma, B-cell Lymphoma, Adult B Cell ALL

07/26

08/26

CYTB323A12101, NCT03960840: Phase I/II Study of Rapcabtagene Autoleucel in CLL, 3L+ DLBCL, ALL and 1L HR LBCL

Recruiting

1/2

225

Europe, Japan, US, RoW

Rapcabtagene autoleucel single agent, Ibrutinib

Novartis Pharmaceuticals

Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Diffuse Large B-cell Lymphoma, Acute Lymphoblastic Leukemia, Large B-cell Lymphoma

06/27

NCT03601442: CTL019 Out of Specification MAP for ALL or DLBCL Patients

Available

N/A

Canada, US, RoW

CTL019, tisagenlecleucel, Kymriah

Novartis Pharmaceuticals

Acute Lymphoblastic Leukemia (ALL), Diffuse Large B-cell Lymphoma (DLBCL)

Chung, Kevin C

NCT04254185: Clinical Trial for Surgery of the Ulnar Nerve (SUN) at the Elbow

Recruiting

N/A

378

Simple decompression, In-situ Decompression, Subcutaneous anterior transposition

University of Michigan, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Curtis National Hand Center, Emory Healthcare, Norton Healthcare, Ohio State University, OrthoCarolina Research Institute, Inc., University of Pittsburgh Medical Center, Wake Forest University Health Sciences, Johns Hopkins University, University of Oklahoma

Neuropathy Ulnar

02/25

Kandzari, David E

TARGET BP I, NCT02910414 / 2016-002545-32: Clinical Trial

Active, not recruiting

300

Dehydrated alcohol, Ethanol, Peregrine System Kit (Sham Procedure)

Ablative Solutions, Inc.

Hypertension

12/23

05/26

NCT02439749: SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study

Completed

N/A

366

Europe, Canada, Japan, US, RoW

Symplicity Spyral™ multi-electrode renal denervation system, Renal angiography, Renal Denervation, Sham Procedure

Medtronic Vascular

Hypertension, Vascular Diseases, Cardiovascular Diseases

04/20

10/23

OPTIMUM, NCT02996877: Outcomes of Surgically Ineligible Patients With Multivessel CAD

Active, not recruiting

N/A

750

Saint Luke's Health System, Piedmont Heart Institute, Inc., Atlanta, GA

Coronary Artery Disease

06/20

06/25

BIOFLOW-VII, NCT04175626: Safety and Effectiveness of the Orsiro Sirolimus Eluting Coronary Stent System in Subjects With Coronary Artery Lesions

Active, not recruiting

N/A

556

Orsiro DES, Orsiro sirolimus coronary stent system

Biotronik, Inc.

Coronary Artery Disease, Atherosclerosis, Coronary, Myocardial Ischemia, Ischemic Heart Disease, Acute Coronary Syndrome, Angina Pectoris

01/22

01/26

NCT02439775: SPYRAL HTN-ON MED Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode Renal Denervation System

Active, not recruiting

N/A

337

Europe, Canada, Japan, US, RoW

Symplicity Spyral™ multi-electrode renal denervation system, Renal angiography, Renal Denervation, Sham Procedure

Medtronic Vascular

Hypertension, Vascular Diseases, Cardiovascular Diseases

08/22

10/25

CRYSTAL, NCT03423511: Trial to Demonstrate the Safety and Effectiveness of the MiStent II for the Revascularization of Coronary Arteries.

Not yet recruiting

N/A

1300

MiStent II coronary artery stent, Xience or Promus coronary artery stents

Micell Technologies, Baim Institute for Clinical Research, North American Science Associates Inc., Yale Cardiovascular Research Group

Coronary Artery Disease

06/23

06/27

NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting

N/A

1400

Europe, US, RoW

Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation

Medtronic Vascular

Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus

11/26

11/29

NCT04849169: Investigation of the Ringer Perfusion Balloon Catheter

Completed

N/A

Experimental

Vascular Solutions LLC

Coronary Artery Perforation

11/23

NCT06358508: Sapphire 3 CTO Study

Not yet recruiting

N/A

170

Sapphire 3 Coronary Dilatation Catheter

OrbusNeich, Avania

Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Heart Diseases, Arteriosclerosis, Cardiovascular Diseases, Chronic Total Occlusion, Chronic Total Occlusion of Coronary Artery

07/25

BACKBEAT, NCT06059638: BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

Recruiting

N/A

500

Europe, US, RoW

Medtronic Astra/Azure DR MRI IPG with AVIM therapy Activated, BackBeat CNT, Medtronic Astra/Azure DR MRI IPG with AVIM therapy Deactivated

Orchestra BioMed, Inc, Medtronic

Hypertension, Hypertension, Systolic, Hypertension,Essential

10/25

06/28

Contact, Use Central

NCT03684018 / 2018-003430-33: Two Dose Levels of Privigen in Pediatric CIDP

Recruiting

IgPro10, Privigen

CSL Behring

Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

12/29

NCT04167514: Treatment of GVHD in Hematopoietic Stem Cell Transplant (HSCT) Recipients Using AAT Plus Corticosteroids (CS) Compared With Corticosteroids Alone (BMT CTN 1705)

Active, not recruiting

136

Alpha-1 antitrypsin (AAT), Alpha-1 proteinase inhibitor (A1-P1), Placebo

CSL Behring, Blood and Marrow Transplant Clinical Trials Network, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI), National Cancer Institute (NCI)

Graft Versus Host Disease (GVHD)

05/24

RECLAIIM, NCT04044690 / 2018-003171-35: A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of IgPro20 in Adults With Dermatomyositis (DM)

Active, not recruiting

126

Europe, Japan, US, RoW

human immunoglobulin G, IgPro20, Hizentra, Placebo

CSL Behring, CSL Behring LLC, 1020 First Avenue, King of Prussia, PA 19406

Dermatomyositis

06/24

11/27

NCT05819775: CSL312_3003 Safety and Pharmacokinetic Study in Subjects 2 to 11 Years of Age With Hereditary Angioedema

Recruiting

Europe, Canada, US, RoW

CSL312, Garadacimab

CSL Behring

Hereditary Angioedema (HAE)

11/26

IMAGINE, NCT03744910 / 2018-003682-34: Clazakizumab for the Treatment of Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients

Terminated

194

Europe, Canada, US, RoW

Clazakizumab, Physiologic saline solution

CSL Behring, ICON Clinical Research

Antibody-mediated Rejection

04/24

NCT06003387: Efficacy and Safety of CSL222 (Etranacogene Dezaparvovec) Gene Therapy in Adults With Hemophilia B With Pretreatment Adeno-associated Virus Serotype 5 (AAV5) Neutralizing Antibodies (Nabs)

Recruiting

Canada, US, RoW

CSL222 (AAV5-hFIXco-Padua), Etranacogene dezaparvovec

CSL Behring

Hemophilia B

10/28

MODULAATE, NCT03805789: The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft-Versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant

Recruiting

2/3

310

Europe, Japan, US, RoW

Alpha-1 antitrypsin (AAT), Alpha-1 proteinase inhibitor, Placebo

CSL Behring

Acute-graft-versus-host Disease

09/25

03/27

NCT05485961: Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis

Enrolling by invitation

2/3

2310

Europe, Canada, US, RoW

CSL300, Clazakizumab, Placebo

CSL Behring

Atherosclerotic Cardiovascular Disease, End Stage Kidney Disease

12/28

NCT01294020 / 2010-020925-42: Study to Compare the Pharmacokinetics of Tacrolimus in Stable Pediatric Allograft Recipients Converted From Prograf® to Advagraf®

Active, not recruiting

Europe, RoW

Tacrolimus, Prograf, FK506, Tacrolimus prolonged release, FK506E, MR4, Advagraf, tacrolimus modified release, Astagraf XL, Graceptor, Prograf XL

Astellas Pharma Europe Ltd.

Intestine Transplantation, Kidney Transplantation, Lung Transplantation, Liver Transplantation, Heart Transplantation

10/15

05/26

STARBORN-1, NCT05871970: Safety and Efficacy Study of Intracystic TARA-002 for the Treatment of Lymphatic Malformations in Participants 6 Months to Less Than 18 Years of Age

Recruiting

TARA-002

Protara Therapeutics

Lymphatic Malformation

12/25

05/26

ADVANCED-2, NCT05951179: Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer

Recruiting

127

US, RoW

TARA-002

Protara Therapeutics

Non-muscle Invasive Bladder Cancer

05/30

08/30

NCT04446000: Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous CSL730 in Healthy Adult Subjects

Terminated

Europe

CSL730, Recombinant trivalent human IgG1 Fc multimer, Placebo

CSL Behring

Immune Complex-mediated Autoimmune Diseases

03/23

NCT05653713: Effects of CSL324 in the Lung After Segmental Challenge

Completed

Europe

CSL324, Recombinant anti-granulocyte colony-stimulating factor (G-CSF) receptor monoclonal antibody (mAb), Placebo

CSL Behring

Healthy Volunteers

07/23

NCT04082754: A Clinical Study to Test the Safety, Exposure, and Pharmacodynamic Markers of CSL311 in Patients With Mild-to-moderate Asthma and in Healthy Volunteers

Completed

Europe

Human beta common receptor antagonist monoclonal antibody, CSL311, Placebo

CSL Behring

Asthma

11/23

ADVANCED-1, NCT05085990: Safety and Toxicity Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer

Recruiting

TARA-002

Protara Therapeutics

Non-muscle Invasive Bladder Cancer

06/24

08/24

ADVANCED-1, NCT05085977: Safety and Toxicity Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer (Phase 1a)

Recruiting

Europe, US, RoW

TARA-002

Protara Therapeutics

Non-muscle Invasive Bladder Cancer

06/24

07/24

NCT05937581: First-In-Human Study To Evaluate The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of Escalating Single And Multiple Doses Of CSL040 In Healthy Subjects

Recruiting

RoW

CSL040, Placebo

CSL Behring

Complement Deficiencies

03/25

THRIVE-1, NCT05011370: Prevalence of Liver Disease in Patients Dependent on Parenteral Nutrition

Completed

N/A

Europe, US

Protara Therapeutics

Intestinal Failure-associated Liver Disease

06/23

IX-TEND 4001, NCT06008938: An Observational Cohort Study to Characterize the Effectiveness and Safety of HEMGENIX® in Patients With Hemophilia B

Recruiting

N/A

500

HEMGENIX, Etranacogene dezaparvovec, Factor IX (FIX)

CSL Behring

Hemophilia B

08/43

Patel, Amar

NCT03816254: A Study of CC-95251, a Monoclonal Antibody Directed Against SIRPα, With Cetuximab in Subjects With Advanced Solid Cancers

Not yet recruiting

140

CC-95251, Cetuximab

Celgene

Neoplasms

04/22

11/23

NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting

N/A

1400

Europe, US, RoW

Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation

Medtronic Vascular

Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus

11/26

11/29

NCT06345690: VIA Disc NP Registry 3.0

Recruiting

N/A

500

VIA Disc NP

VIVEX Biologics, Inc., Moxie Clinical

Discogenic Pain, Back Pain, Back Pain, Low

01/27

NCT05425459: RESPONDER-HF Trial

Recruiting

N/A

750

Europe, Canada, US, RoW

Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)

Corvia Medical

Heart Failure, Heart Failure, Diastolic

05/25

03/31

SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting

N/A

958

Canada, US

Tendyne Mitral Valve System, MitraClip System

Abbott Medical Devices

Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease

06/24

06/28

Nathan, Sandeep

NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting

N/A

1400

Europe, US, RoW

Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation

Medtronic Vascular

Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus

11/26

11/29

ARIVE-PCI, NCT01278043: Antiplatelet Response, Interval Variability & Events in Percutaneous Coronary Intervention () Registry

Active, not recruiting

N/A

100

University of Chicago

Coronary Artery Disease

05/24

CSWG, NCT04682483: Cardiogenic Shock Working Group Registry

Recruiting

N/A

5000

Vasopressor, Inotrope, Acute Mechanical Circulatory Support Devices

Tufts Medical Center, Abbott, Boston Scientific Corporation, Abiomed Inc., Getinge Group

Cardiogenic Shock

01/25

06/25

Xu, Wei

NCT05931263: A Randomized Clinical Trial Comparing Chi-BEAM With BEAM Regimen Combined With ASCT for the Treatment of ND PTCL

Recruiting

104

RoW

C-BEAM Regimen, BEAM Regimen

The First Affiliated Hospital with Nanjing Medical University

Newly Diagnosed Peripheral T-cell Lymphoma

02/26

02/28

ICP-CL-01203, NCT06378138: ICP-248 in Combination With Orelabrutinib in Treatment-naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Not yet recruiting

2/3

226

RoW

ICP-248, Orelabrutinib

Beijing InnoCare Pharma Tech Co., Ltd.

Hematologic Malignancies

11/30

07/31

NCT04423926: Lenalidomide in Combination With CHOP in Patients With Untreated PTCL

Recruiting

RoW

Lenalidomide, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone

The First Affiliated Hospital with Nanjing Medical University

PTCL, NOS, AITL, ALK- ALCL, Phase III-IV ALK+ ALCL, EATL

12/22

12/24

NCT04438005: A Study of ICP-022 in Patients With R/R DLBCL

Completed

RoW

ICP-022

Beijing InnoCare Pharma Tech Co., Ltd.

Diffuse Large B Cell Lymphoma

11/21

12/21

NCT05241132: Tislelizumab Combined With Chemotherapy in the Treatment of Bone Metastases of Unknown Primary

Recruiting

RoW

Tislelizumab plus chemotherapy, Cisplatin, Paclitaxel

Wei Xu

Cancer of Unknown Primary, Bone Cancer Metastatic, Tislelizumab, Gene Mutation-Related Cancer, Immune Evasion, Tumor, Chemotherapy Effect

06/23

10/24

NCT04181489: Sintilimab in Combination With R-CHOP in Patients With Treatment-naive EBV-positive DLBCL, NOS

Recruiting

RoW

Sintilimab, Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone

The First Affiliated Hospital with Nanjing Medical University

EBV-Positive DLBCL, Nos

12/23

NCT05186558: Penpulimab Plus R2-GemOx Regimen in Relapsed or Refractory DLBCL

Not yet recruiting

RoW

penpulimab, lenalidomide, Rituximab, Gemcitabine, Oxaliplatin, lenalidomide, Rituximab, Gemcitabine, Oxaliplatin

The First Affiliated Hospital with Nanjing Medical University

Lymphoma, Large B-Cell, Diffuse, Neoplasms by Histologic Type

01/24

02/26

NCT05716087: A Study of LP-168 in Participants With Relapse or Refractory Mantle Cell Lymphoma

Recruiting

RoW

LP-168, NWP-775

Guangzhou Lupeng Pharmaceutical Company LTD.

Mantle Cell Lymphoma (MCL)

02/24

12/25

NCT04432714: Lenalidomide in Combination With R-DA-EPOCH in Patients With Untreated DLBCL With MYC Rearrangement

Recruiting

RoW

Lenalidomide, Rituximab, Etoposide, Doxorubicin, Vincristine, Cyclophosphamide, Prednisone

The First Affiliated Hospital with Nanjing Medical University

DLBCL, Untreated, MYC Gene Rearrangement

12/24

12/26

NCT04808570: A Study of TQ-B3525 in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Terminated

1/2

RoW

TQ-B3525 tablets

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

11/23

NCT05323201: Study Of B7H3 CAR-T Cells in Treating Advanced Liver Cancer

Recruiting

1/2

RoW

fhB7H3.CAR-Ts, B7H3 targeting chimeric antigen receptor T cells, Fludarabine, FLUDARA, Cyclophosphamide, Cytoxan

The Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, IIT MediTech Co. Ltd

Hepatocellular Carcinoma

02/24

02/27

TEACH, NCT04281420: A Study of Evaluating Dual Inhibitor of PAK4 and NAMPT ATG-019 in Advanced Solid Tumors or Non-Hodgkin's Lymphoma

Terminated

RoW

ATG-019, KPT-9274, ATG-019 + Niacin ER

Antengene Therapeutics Limited

Solid Tumor, Non-Hodgkin's Lymphoma

10/23

NCT05683717: A Phase 1 Study to Evaluate the Safety and Tolerability of TT-01488 in Patients With B-Cell Malignancies

Recruiting

RoW

TT-01488 Tablets

TransThera Sciences (Nanjing), Inc.

B-Cell Malignancies

10/26

10/28

NCT05173467: Robot-assisted Invasion-controlled Surgery Versus Traditional-open Surgery Against Metastatic Spinal Tumor

Not yet recruiting

N/A

RoW

Robot-assisted Invasion-controlled Surgery, Traditional-open Surgery

Wei Xu

Minimally Invasive Surgery, Spinal Metastases

12/22

12/23

NCT04432402: Lenalidomide in Combination With R-GemOx in First-line Treatment of Elderly Diffuse Large B Cell Lymphoma

Recruiting

N/A

124

RoW

Lenalidomide, Rituximab, Gemcitabine, oxaliplatin

The First Affiliated Hospital with Nanjing Medical University

Diffuse Large B Cell Lymphoma

12/22

12/24

Cryo-InitialAF, NCT04942834: Using Cryoballoon Ablation as Initial Treatment for Persistent Atrial Fibrillation

Recruiting

N/A

286

RoW

Antiarrhythmic drug including Propafenone, Sotalol, Dronedarone and Amiodarone, cryoballoon ablation

Ruijin Hospital

Atrial Fibrillation, Persistent, Arrhythmias, Cardiac

07/25

01/26

NCT05777369: R-CMOP in Patients With Primary Diffuse Large B-cell Lymphoma

Not yet recruiting

N/A

Rituximab, Mitoxantrone hydrochloride liposome, Cyclophosphamide, Vincristine/Vindesine, Prednisone

The First Affiliated Hospital with Nanjing Medical University

Diffuse Large B-cell Lymphoma

08/23

08/24

NCT06211881: Chi-GVM Regimen for the Treatment of R/R PTCL

Recruiting

N/A

RoW

Chi-GVM, Chidamide Combined With Gemcitabine, Vinorelbine, and Mitoxantrone Hydrochloride Liposome

The First Affiliated Hospital with Nanjing Medical University

Relapsed/Refractory Peripheral T-cell Lymphoma

09/25

NCT05784987: R-MINE+X in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

Not yet recruiting

N/A

Rituximab, Mitoxantrone hydrochloride liposome, Isophosphamide, Etoposide, X: Orelabrutinib, X: Chidamide, X: Penpulimab, X: Lenalidomide

The First Affiliated Hospital with Nanjing Medical University

Diffuse Large B-cell Lymphoma

01/24

01/25

NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting

N/A

1400

Europe, US, RoW

Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation

Medtronic Vascular

Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus

11/26

11/29

EVL, NCT06250803: Early Pancreatic Stent Placement for Preventing PEP

Not yet recruiting

N/A

768

RoW

early pancreatic stent placement (EPSP), late pancreatic stent placement (EPSP)

The First Affiliated Hospital of Anhui Medical University, First Affiliated Hospital Bengbu Medical College, Anqing Municipal Hospital, First Affiliated Hospital of Wannan Medical College, Tongcheng People's Hospital of Anhui province, Fuyang people's hospital

Cholangiopancreatography, Endoscopic Rretrograde, Post-ERCP Pancreatitis

03/26

COSIRA-II, NCT05102019: Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II

Recruiting

N/A

380

Canada, US

Arm 1: treatment with Neovasc Reducer, Arm 2 (control): Implantation procedure with no device implanted, Arm 3 (unblinded, non-randomized): Single arm registry

Neovasc Inc., Shockwave Medical, Inc.

Refractory Angina

06/24

12/28

NCT05426824: The Whole-course Management of Pegaspargase in ENKTL

Not yet recruiting

N/A

RoW

Pegaspargase（P-GOD）, Pegaspargase（PEMD）

The First Affiliated Hospital with Nanjing Medical University

Extranodal NK/T Cell Lymphoma

07/24

07/25

NCT04837222: A Study of Brentuximab Vedotin in Adults With CD30-positive Lymphoma

Recruiting

N/A

1000

RoW

No Intervention

Takeda

Lymphoma

01/25

NCT05896813: CMOP Regimen and Chidamide in the Treatment of Newly Diagnosed Peripheral T-cell Lymphoma

Recruiting

N/A

RoW

CMOP+Chidamide

The First Affiliated Hospital with Nanjing Medical University

Newly Diagnosed Peripheral T-cell Lymphoma

01/25

EMPOWER CAD, NCT05755711: Equity in Modifying Plaque Of WomEn With UndeRtreated Calcified Coronary Artery Disease

Recruiting

N/A

400

Europe, US

Shockwave Medical Coronary IVL System

Shockwave Medical, Inc.

Coronary Artery Disease

04/25

04/28

NCT05343377: A Clinical Study of the Value of Circulating Free Methylated EBV DNA in Extranodal NK/T Cell Lymphoma

Not yet recruiting

N/A

RoW

circulate free methylated EBV DNA

The First Affiliated Hospital with Nanjing Medical University, Zhenjiang First People's Hospital, Changzhou First People's Hospital, Changzhou Second People's Hospital, Wuxi People's Hospital, Second Affiliated Hospital of Soochow University, The First Affiliated Hospital of Nantong University, Huaian first people's hospital, Yancheng First People's Hospital

Extranodal Natural Killer/T-cell Lymphoma

06/25

06/28

NCT06120426: En Bloc Resection Versus Separation Surgery Combined With Radiotherapy for the Treatment of Spinal Oligometastatic Tumor.

Recruiting

N/A

182

RoW

total en bloc spondylectomy

Shanghai Changzheng Hospital, Peking University Third Hospital, Peking University People's Hospital, Henan Cancer Hospital, First Affiliated Hospital, Sun Yat-Sen University, Sun Yat-sen University, Zhejiang University, Tianjin Hospital, The First Affiliated Hospital of Nanchang University, The Third Affiliated Hospital of Southern Medical University

Spinal Metastases, Spinal Tumor, Radiotherapy, Malignant Bone Tumor, Surgery

07/25

07/27

NCT05677100: Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

Recruiting

N/A

268

Aortix System, Aortix Pump

Procyrion

Heart Failure, Cardiorenal Syndrome, Cardio-Renal Syndrome, ADHF, Heart Failure, Systolic, Heart Failure, Diastolic, Heart Failure; With Decompensation, Heart Failure, Congestive

07/25

12/25

NCT05967949: A Retrospective Clinical Study on the First-line Maintenance Treatment of PTCL With Chidamide.

Recruiting

N/A

200

RoW

chidamide

The First Affiliated Hospital with Nanjing Medical University

PTCL

04/26

04/28

NCT05645302: Intensive Monitoring Scheme of Lidocaine Cataplasms

Recruiting

N/A

200

RoW

Lidocaine Cataplasms

Qianfoshan Hospital

Adverse Reaction to Drug

10/22

12/22

Brown, John

CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting

N/A

1247

Europe, Canada, US

Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System

Edwards Lifesciences

Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation

01/25

04/30

iAccelerate, NCT05329584: InSpace Accelerated Rehabilitation Study

Recruiting

N/A

160

InSpace Subacromial Tissue Spacer

Stryker Endoscopy

Rotator Cuff Tears

04/24

04/25

APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting

N/A

1056

Europe, Canada, US

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Medtronic Cardiovascular

Mitral Valve Regurgitation

10/26

09/36

ACTION, NCT05773144: Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer

Recruiting

N/A

219

Aerobic exercise, Progressive stretching

Pennington Biomedical Research Center, National Cancer Institute (NCI)

Colonic Neoplasms

05/27

Pederson, David

NCT05809596: HEAL-LAA Clinical Trial

Recruiting

N/A

1000

WATCHMAN FLX Pro LAAC Device, Left Atrial Appendage Closure

Boston Scientific Corporation

Atrial Fibrillation, Bleeding, Stroke

08/24

06/25

NCT05434650: Abbott Atrial Fibrillation Post Approval Study

Recruiting

N/A

200

electrophysiology study and ablation with an Abbott Ablation Catheter

Abbott Medical Devices

Atrial Arrhythmia, Atrium; Fibrillation, Atrial Tachycardia

10/24

11/26

NCT04431544: AcQMap® US Registry of Procedural and Long-term Clinical Outcomes (Discover-US)

Terminated

N/A

513

AcQMap System

Acutus Medical

Ablation of Arrhythmia's

11/23

Kunavarapu, Chandra

APEX-AV, NCT05318092: Evaluating the Safety and Efficacy of the AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 PE for Treatment of Acute Pulmonary Embolism

Completed

N/A

122

AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 PE

Angiodynamics, Inc.

Pulmonary Embolism, Acute Pulmonary Embolism

01/24

PEERLESS, NCT05111613: The Study

Completed

N/A

550

Europe, US

Catheter-Directed Thrombolysis, FlowTriever System

Inari Medical

Pulmonary Embolism, Pulmonary Thrombo-embolism

03/24

04/24

NCT06055920: The PEERLESS II Study

Recruiting

N/A

1200

Europe, Canada, US

FlowTriever System, Anticoagulation Agents

Inari Medical

Pulmonary Embolism

07/26

NCT05934487: PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

Recruiting

N/A

1650

Cordella™ Pulmonary Artery Sensor System

Endotronix, Inc.

Heart Failure NYHA Class II, Heart Failure NYHA Class III

09/27

09/29

Mayoral, Jaime

NCT03827967: Trial of PalloV-CC in Colon Cancer

Completed

PalloV-CC

George E. Peoples, PalloV, LLC

Colon Cancer

04/23

05/23

ECLIPSE, NCT04136002: Evaluation of the ctDNA LUNAR Test in an Average Patient Screening Episode

Active, not recruiting

N/A

44467

Guardant Health, Inc., Premier Research Group plc

Colorectal Cancer

03/24

12/25

Devireddy, Chandan

PORTICO IDE, NCT02000115: Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial

Recruiting

N/A

1150

US, RoW

Portico transcatheter aortic valve, Commercially available transcatheter aortic valve

Abbott Medical Devices

Aortic Valve Stenosis

10/19

07/25

NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting

N/A

1400

Europe, US, RoW

Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation

Medtronic Vascular

Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus

11/26

11/29

IMPACT SDM, NCT06171737: Promoting Shared Decision Making for Severe Aortic Stenosis

Not yet recruiting

N/A

1400

Decision Aid, Shared Decision Making Skills Training

Massachusetts General Hospital, University of California, San Francisco, University of Colorado, Denver, University of North Carolina, Chapel Hill, Piedmont Healthcare, Providence Health & Services, University of Texas, Emory University, Patient-Centered Outcomes Research Institute

Aortic Stenosis

05/27

10/27

NCT05677100: Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

Recruiting

N/A

268

Aortix System, Aortix Pump

Procyrion

Heart Failure, Cardiorenal Syndrome, Cardio-Renal Syndrome, ADHF, Heart Failure, Systolic, Heart Failure, Diastolic, Heart Failure; With Decompensation, Heart Failure, Congestive

07/25

12/25

Cruz, Jose De La

PhALLCON, NCT03589326 / 2018-000397-30: A Study of Ponatinib Versus Imatinib in Adults With Acute Lymphoblastic Leukemia

	Data from PhALLCON Study for newly diagnosed Ph+ ALL at SOHO 2020
	Sep 2019 - Sep 2019: Data from PhALLCON Study for newly diagnosed Ph+ ALL at SOHO 2020
	Initiation of new trial in Ph+ ALL
	Jul 2018 - Jul 2018: Initiation of new trial in Ph+ ALL

Active, not recruiting

245

Europe, Canada, Japan, US, RoW

Ponatinib, Iclusig, Imatinib, Gleevec, Vincristine, Dexamethasone, Cytarabine, Methotrexate, Prednisone

Takeda

Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL)

08/22

07/27

EVOLVE CLL/SLL, NCT04269902: Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), Study

Recruiting

247

Canada, US

Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy, Biopsy of Bone Marrow, Biopsy, Bone Marrow, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Obinutuzumab, Anti-CD20 Monoclonal Antibody R7159, GA 101, GA-101, GA101, Gazyva, huMAB(CD20), R 7159, R-7159, R7159, RO 5072759, RO-5072759, RO5072759, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Venetoclax, ABT 199, ABT-0199, ABT-199, ABT199, GDC 0199, GDC-0199, GDC0199, RG7601, Venclexta, Venclyxto

National Cancer Institute (NCI)

Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

10/28

COBRA, NCT04068103: Circulating Tumor DNA Testing in Predicting Treatment for Patients With Stage IIA Colon Cancer After Surgery

Active, not recruiting

2/3

1408

Canada, US

Capecitabine, Ro 09-1978/000, Xeloda, Fluorouracil, 5-Fluoro-2,4(1H, 3H)-pyrimidinedione, 5-Fluorouracil, 5-Fluracil, 5-FU, AccuSite, Carac, Fluoro Uracil, Fluouracil, Flurablastin, Fluracedyl, Fluracil, Fluril, Fluroblastin, Ribofluor, Ro 2-9757, Ro-2-9757, Leucovorin, Folinic acid, Leucovorin Calcium, Adinepar, Calcifolin, Calcium (6S)-Folinate, Calcium Folinate, Calcium Leucovorin, Calfolex, Calinat, Cehafolin, Citofolin, Citrec, citrovorum factor, Cromatonbic Folinico, Dalisol, Disintox, Divical, Ecofol, Emovis, Factor, Citrovorum, Flynoken A, Folaren, Folaxin, FOLI-cell, Foliben, Folidan, Folidar, Folinac, Folinate Calcium, folinic acid, Folinic Acid Calcium Salt Pentahydrate, Folinoral, Folinvit, Foliplus, Folix, Imo, Lederfolat, Lederfolin, Leucosar, leucovorin, Rescufolin, Rescuvolin, Tonofolin, Wellcovorin, Oxaliplatin, 1-OHP, Ai Heng, Aiheng, Dacotin, Dacplat, Diaminocyclohexane Oxalatoplatinum, Eloxatin, Eloxatine, JM-83, Oxalatoplatin, Oxalatoplatinum, RP 54780, RP-54780, SR-96669, Patient Observation, Active Surveillance, deferred therapy, expectant management, observation, Watchful Waiting

NRG Oncology, National Cancer Institute (NCI)

Colon Adenocarcinoma, Stage IIA Colon Cancer AJCC v8

04/25

04/27

CIRCULATE-US, NCT05174169: Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

Recruiting

2/3

1912

Canada, US

Signatera test, mFOLFOX6 3-6 month, CAPOX 3 month, mFOLFIRINOX, mFOLFOX6 6 month, CAPOX 6 month

NRG Oncology, Natera, Inc., National Cancer Institute (NCI)

Stage III Colon Cancer

03/29

03/30

ACCESS, NCT04904588: HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide

Recruiting

300

Busulfan, Busulfex®, Fludarabine, Fludara®, Total-body irradiation, TBI, Cyclophosphamide, Cytoxan®, Melphalan, PBSC Hematopoietic Stem Cell Transplantation (HSCT), PBSC HSCT, PBSC HCT, PBSC Transplantation, Bone Marrow Hematopoietic Stem Cell Transplantation, BM HSCT, BM HCT, Bone Marrow Transplantation, Post-transplant Cyclophosphamide, Mesna, Mesnex®, Tacrolimus, Mycophenolate Mofetil, MMF, Cellcept®, Patient-Reported Outcomes

Center for International Blood and Marrow Transplant Research, National Marrow Donor Program

Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, Mixed Phenotype Acute Leukemia, Acute Leukemia, Myelodysplastic Syndromes, Chronic Myelogenous Leukemia, Chronic Lymphocytic Leukemia, Lymphoma

07/24

NCT05898776: 10°C vs 4°C Lung Preservation RCT

Recruiting

N/A

300

Europe, Canada, US

Lung transplantation after 10°C donor lung preservation, Lung transplantation after standard ice cooler donor lung preservation

University Health Network, Toronto, Medical University of Vienna, Vanderbilt University, Puerta de Hierro University Hospital, University of California, San Francisco, Centre Hospitalier Universitaire Vaudois

Lung Transplant, Organ Preservation

07/25

07/26

NCT01351545: A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

Recruiting

N/A

99999

A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs)

Center for International Blood and Marrow Transplant Research, National Marrow Donor Program

Hematologic Malignancies, Inherited Disorders of Metabolism, Inherited Abnormalities of Platelets, Histiocytic Disorders, Acute Myelogenous Leukemia (AML or ANLL), Acute Lymphoblastic Leukemia (ALL), Other Acute Leukemia, Chronic Myelogenous Leukemia (CML), Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases, Other Leukemia, Hodgkin Lymphoma, Non-hodgkin Lymphoma, Multiple Myeloma/ Plasma Cell Disorder (PCD), Inherited Abnormalities of Erythrocyte Differentiation or Function, Disorders of the Immune System, Autoimmune Diseases, Severe Aplastic Anemia

10/41

Perez, Jose

NCT03596385 / 2017-002485-40: TREatment With Beta-blockers After myOcardial Infarction withOut Reduced Ejection fracTion"

Recruiting

8468

Europe

Beta blocker, atenolol, bisoprolol, carvedilol, metoprolol, nevibolol.

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III

Myocardial Infarction

04/25

VICTORION-2P, NCT05030428: Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease

Active, not recruiting

17006

Europe, Canada, Japan, US, RoW

Inclisiran sodium 300 mg, Placebo

Novartis Pharmaceuticals

Atherosclerotic Cardiovascular Disease

10/27

BRUIN-CLL-314, NCT05254743 / 2021-003206-41: A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Recruiting

650

Europe, Canada, Japan, US, RoW

Pirtobrutinib, LOXO-305, LY3527727, Ibrutinib

Loxo Oncology, Inc., Eli Lilly and Company

Chronic Lymphocytic Leukemia, Leukemia, Lymphocytic, Leukemia, B-cell, Small Lymphocytic Lymphoma

02/25

08/28



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