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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
Böhm, Michael
NCT02439749: SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study	Completed	N/A	366	Europe, Canada, Japan, US, RoW	Symplicity Spyral™ multi-electrode renal denervation system, Renal angiography, Renal Denervation, Sham Procedure	Medtronic Vascular	Hypertension, Vascular Diseases, Cardiovascular Diseases	04/20	10/23
NCT02439775: SPYRAL HTN-ON MED Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode Renal Denervation System	Active, not recruiting	N/A	337	Europe, Canada, Japan, US, RoW	Symplicity Spyral™ multi-electrode renal denervation system, Renal angiography, Renal Denervation, Sham Procedure	Medtronic Vascular	Hypertension, Vascular Diseases, Cardiovascular Diseases	08/22	10/25
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN	Recruiting	N/A	1400	Europe, US, RoW	Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation	Medtronic Vascular	Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus	11/26	11/29
NCT01534299: Global SYMPLICITY Registry (GSR) DEFINE	Recruiting	N/A	5000	Europe	Medtronic Renal Denervation System	Medtronic Vascular	Hypertension	04/26	08/31
Ukena, Christian
NCT04898361: PFO Occlusion and Atrial Fibrillation	Recruiting	N/A	50	Europe	PFO closure	University Hospital, Saarland	Atrial Fibrillation New Onset, Embolic Stroke of Undetermined Source, Patent Foramen Ovale	06/21	06/22
HOM-TAVI, NCT04128384: Infranodal Conduction Time During TAVR as Predictor of HAVB	Recruiting	N/A	200	Europe	Limited electrophysiologic study including measurements of HV- and AH-intervals pre- and post-TAVR	University Hospital, Saarland	Severe Aortic Valve Stenosis, High-degree AV Block, Left Bundle-Branch Block	12/21	01/23
NCT05951101: Zenith LAA Occlusion System	Recruiting	N/A	10	RoW	Zenith LAA Occlusion System	AuriGen Medical Ltd	Atrial Fibrillation, Left Atrial Appendage, Stroke	01/25	12/25
CLEARANCE, NCT04298723: Comparison of LAA-Closure vs Oral Anticoagulation in Patients With NVAF and Status Post Intracranial Bleeding.	Recruiting	N/A	530	Europe	Percutaneous closure of the LAA (Watchman / Watchman FLX)	Jena University Hospital	Atrial Fibrillation (AF), Intracranial Bleed	06/27	06/27