| Weber, Thomas |
AlloRelapseMM, NCT05675319: Allogeneic Stem Cell Transplantation vs. Conventional Therapy as Salvage Therapy for Relapsed / Progressive Patients With Multiple Myeloma After First-line Therapy |
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| Recruiting | 3 | 482 | Europe | Allogeneic Stem Cells, carfilzomib/lenalidomide/dexamethasone (KRD), elotuzumab/lenalidomide/dexamethasone (ERD), daratumumab/bortezomib/dexamethasone (DVD), daratumumab/lenalidomide/dexamethasone (DRD), ixazomib/lenalidomide/dexamethasone (IRD), pomalidomide/bortezomib/dexamethasone (PVD), carfilzomib/daratumumab/dexamethasone (KDD), Autologous Stem Cells, daratumumab/pomalidomide/dexamethasone (DPD), isatuximab/carfilzomib/dexamethasone (Isa-KD), selinexor/bortezomib/dexamethasone (SVD) | Universitätsklinikum Hamburg-Eppendorf, Gemeinsamer Bundesausschuss (G-BA), Staburo GmbH | Multiple Myeloma | 03/28 | 03/33 | | |
| Active, not recruiting | 2 | 36 | Europe | Copanlisib, Aliqopa, Rituximab, Truxima | Christian Buske, University of Ulm, Optimapharm, X-act Cologne Clinical Research GmbH, Zentrum für Klinische Studien Ulm, Celltrion Healthcare Co., LTD, Bayer | Marginal Zone Lymphoma | 06/24 | 12/29 | | |
R-Pola-Glo, NCT05798156: Rituximab in Combination with Glofitamab and Polatuzumab Vedotin in Patients with Previously Untreated Aggressive B-cell Lymphoma Ineligible for R-CHOP |
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| Recruiting | 2 | 125 | Europe | Glofitamab, Rituximab, Obinutuzumab, Polatuzumab vedotin | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, Charite University, Berlin, Germany, University of Salzburg, Arbeitsgemeinschaft medikamentoese Tumortherapie, Roche Pharma AG, Zentrum für Klinische Studien Leipzig, Hoffmann-La Roche | Lymphoma, Large B-Cell, Diffuse | 04/25 | 09/28 | | |
| Recruiting | N/A | 1000 | Europe | | Medical University of Graz | Hypertrophic Cardiomyopathy | 03/44 | 03/44 | | |
TOGETHER, NCT06761235: Knowledge of Vascular Age Contributes to Improve the Collaboration Between Community Pharmacies and Primary Health Care Physicians in Reducing Blood Pressure in Hypertensive Patients. |
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| Not yet recruiting | N/A | 1246 | Europe | Standard BP intervention, Ambulatory blood pressure monitoring to diagnose hypertension and educational sessions to empower hypertensive patients, EVA intervention, Ambulatory blood pressure monitoring to diagnose hypertension plus estimated vascular age by brachial oscillometry and educational sessions to empower hypertensive patients | Enrique Rodilla, Health Research Fund of ISCIII Spain, AIT Austrian Institute of Technology GmbH, Institut et Haute Ecole de la Santé la Source, Instituto Politécnico de Coimbra, European Union | Hypertension and Cardiovascular Risk Factors | 11/26 | 12/26 | | |
| Seufferlein, Thomas |
PANOVA-3, NCT03377491: Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel |
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| Completed | 3 | 571 | Europe, Canada, US, RoW | NovoTTF-200T, TTFields, Gemcitabine, nab paclitaxel | NovoCure Ltd. | Pancreas Adenocarcinoma | 10/24 | 10/24 | | |
| Recruiting | 3 | 400 | Europe, Canada, Japan, US, RoW | tucatinib, TUKYSA, ONT-380, ARRY-380, PF-07265792, trastuzumab, Herceptin, bevacizumab, Avastin, cetuximab, Erbitux, oxaliplatin, leucovorin, levoleucovorin, fluorouracil | Seagen Inc., Merck Sharp & Dohme LLC | Colorectal Neoplasms | 08/25 | 04/28 | | |
| Completed | 1/2 | 167 | Europe | CAN04, Cisplatin, Gemcitabine, Nab-paclitaxel, Carboplatin, Pemetrexed | Cantargia AB | Non Small Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma, Triple Negative Breast Cancer, Colorectal Cancer | 03/24 | 03/24 | | |
| Recruiting | 1/2 | 18 | Europe | Maximum tolerated dose, MTD: D,L-methadone hydrochloride (Methasan® 10 mg/ml) | AIO-Studien-gGmbH, Deutsche Krebshilfe e.V., Bonn (Germany) | Chemo-refractory Colorectal Carcinoma | 06/25 | 06/25 | | |
ARCHES, NCT05041283: Impact of Artificial Intelligence-based Patient Reinforcement on Quality of Colonoscopy |
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| Recruiting | N/A | 258 | Europe | Chatbot, Phone call | University of Ulm | Bowel Preparation | 02/22 | 02/22 | | |
| Recruiting | N/A | 5000 | Europe | | ClarData | COVID-19 | 12/22 | 06/23 | | |
| Recruiting | N/A | 200 | Europe | Liquid Biopsy | Ludwig-Maximilians - University of Munich, Hoffmann-La Roche | Pancreas Cancer | 12/24 | 12/25 | | |
| Recruiting | N/A | 5000 | Europe | | University of Ulm | Pancreas Adenocarcinoma, Pancreas Cancer | 10/28 | 10/29 | | |
NCT04686409: App-based Symptom Tracking After Corona Vaccination (CoCoV) |
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| Not yet recruiting | N/A | 500 | Europe | COVID-19 vaccines | University of Ulm | Adverse Events in COVID-19 Vaccination | 01/22 | 08/22 | | |
| Büchner-Steudel, Petra |
| Completed | N/A | 400 | Europe | FoundationOne®CDx and FoundationOne®Liquid | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, Roche Pharma AG | Hepatocellular Cancer, Cholangiocarcinoma, Gallbladder Cancer, Pancreatic Cancer, Oesophageal Cancer, Stomach Cancer | 08/24 | 08/24 | | |
| Active, not recruiting | N/A | 1000 | Europe | | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | Hepatocellular Cancer, Cholangiocarcinoma, Gallbladder Cancer, Pancreatic Cancer, Oesophageal Cancer, Stomach Cancer | 05/32 | 05/32 | | |
| Valipour, Arschang |
| Completed | 2 | 119 | Europe | BC 007 or matching placebo | Berlin Cures GmbH, Berlin Cures GmbH | Long Covid | 06/24 | 09/24 | | |
NCT06035120: An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients with Severe Emphysema |
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| Recruiting | N/A | 200 | Europe, US, RoW | AeriSeal System | Pulmonx Corporation | Emphysema, Pulmonary, Emphysema or COPD | 06/27 | 03/28 | | |
NCT06522334: Interstitial Lung Disease Registry Study: Prospective and Retrospective Observational Study in Austria |
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| Recruiting | N/A | 400 | Europe | | Ludwig Boltzmann Institute for Lung Health | Interstitial Lung Disease | 02/34 | 02/34 | | |
RheSolve, NCT04677465: Clinical Study of the RheOx Bronchial Rheoplasty System in Treating the Symptoms of Chronic Bronchitis |
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| Active, not recruiting | N/A | 270 | Europe, US | RheOx Bronchial Rheoplasty, Sham Procedure | Gala Therapeutics, Inc. | Chronic Bronchitis | 05/24 | 10/25 | | |
| Active, not recruiting | N/A | 464 | Europe, US | Targeted Lung Denervation (TLD), TLD, TLD Therapy, Optimal Medical Care | Nuvaira, Inc. | COPD | 10/24 | 09/28 | | |
| Recruiting | N/A | 100 | Europe | RheOx | Gala Therapeutics, Inc. | Chronic Bronchitis, COPD | 12/24 | 12/25 | | |
NCT06655428: The REDUCE EU Study - Endobronchial Thermal Liquid Ablation (ETLA) for the Treatment of Emphysema |
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| Recruiting | N/A | 30 | Europe | Endobronchial Therman Liquid Ablation (ETLA), Bronchoscopic lung volume reduction | Morair Medtech, LLC | Emphysema or COPD, Emphysema, Emphysema, Pulmonary, COPD, COPD (Chronic Obstructive Pulmonary Disease) | 02/26 | 05/26 | | |
BREATHE-2, NCT05949645: Study to Assess Safety, Feasibility, and Preliminary Efficacy of the Apreo Implant for Severe Emphysema |
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| Active, not recruiting | N/A | 30 | Europe | Apreo Implant Group | Apreo Health, Inc. | Emphysema or COPD | 10/24 | 06/26 | | |
| Recruiting | N/A | 300 | Europe | Bronchoscopic Thermal Vapor Ablation, BTVA, InterVapor | Uptake Medical Technology, Inc. | Emphysema or COPD | 12/27 | 12/30 | | |
| Not yet recruiting | N/A | 10 | Europe | Bronchoscopic Thermal Vapor Ablation, BTVA-C | Uptake Medical Technology, Inc. | Non Small Cell Lung Cancer, Metastatic Lung Cancer, Lung Cancer | 03/26 | 06/26 | | |
| Müller, Lutz P |
GRAPPA, NCT05153226: GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG |
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| Active, not recruiting | 3 | 640 | Europe | Cyclophosphamide, all brands, ATG, ATG Grafalon | DKMS gemeinnützige GmbH | Graft Vs Host Disease, Peripheral Blood Stem Cell Transplantation, AML, MDS, MDS/MPN, CMML | 06/25 | 12/26 | | |
AlloRelapseMM, NCT05675319: Allogeneic Stem Cell Transplantation vs. Conventional Therapy as Salvage Therapy for Relapsed / Progressive Patients With Multiple Myeloma After First-line Therapy |
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| Recruiting | 3 | 482 | Europe | Allogeneic Stem Cells, carfilzomib/lenalidomide/dexamethasone (KRD), elotuzumab/lenalidomide/dexamethasone (ERD), daratumumab/bortezomib/dexamethasone (DVD), daratumumab/lenalidomide/dexamethasone (DRD), ixazomib/lenalidomide/dexamethasone (IRD), pomalidomide/bortezomib/dexamethasone (PVD), carfilzomib/daratumumab/dexamethasone (KDD), Autologous Stem Cells, daratumumab/pomalidomide/dexamethasone (DPD), isatuximab/carfilzomib/dexamethasone (Isa-KD), selinexor/bortezomib/dexamethasone (SVD) | Universitätsklinikum Hamburg-Eppendorf, Gemeinsamer Bundesausschuss (G-BA), Staburo GmbH | Multiple Myeloma | 03/28 | 03/33 | | |
| Completed | 2/3 | 98 | Europe | Peripheral blood stem cells, PBSC | DKMS gemeinnützige GmbH | AML, ALL, MDS | 04/24 | 04/24 | | |
NCT03188874: Clinical AML Registry and Biomaterial Database of the Study Alliance Leukemia (SAL) |
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| Recruiting | N/A | 15000 | Europe | | Technische Universität Dresden | Acute Myeloid Leukemia (AML) | 09/30 | 09/30 | | |
| Voiosu, Theodor |
| Recruiting | 3 | 612 | Europe, Canada, Japan, US, RoW | ABX464, Obefazimod, Placebo | Abivax S.A. | Ulcerative Colitis | 03/25 | 04/25 | | |
| Recruiting | 3 | 778 | Europe, Canada, Japan, US, RoW | Mirikizumab, LY3074828 | Eli Lilly and Company | Crohn's Disease | 11/24 | 12/26 | | |
| Recruiting | 3 | 1050 | Europe, Canada, Japan, US, RoW | ABX464, Obefazimod, Placebo | Abivax S.A. | Ulcerative Colitis | 01/26 | 01/30 | | |
| Recruiting | 3 | 1063 | Europe, Canada, Japan, US, RoW | Mirikizumab, LY3074828 | Eli Lilly and Company | Ulcerative Colitis | 07/26 | 12/27 | | |
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| Active, not recruiting | N/A | 30 | Europe | Endoluminal radiofrequency ablation, Endoscopic biliary stenting | Clinical Hospital Colentina, Carol Davila University of Medicine and Pharmacy, Universitatea din Bucuresti | Perihilar Cholangiocarcinoma | 10/24 | 12/24 | | |
| Sinn, Marianne |
NCT05008809: Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418) |
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| Recruiting | 3 | 507 | Europe | mFOLFOX6, Folinic acid, Oxaliplatin, 5-fluorouracil (FU), mFOLFOXIRI, Folinic acid, Oxaliplatin, 5-FU, Irinotecan, FOLFIRI, Folinic acid, 5-FU, CAPOX, Capecitaine, Oxaliplatin | Dominik Paul Modest, German Research Foundation, Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | Colorectal Cancer | 11/27 | 11/30 | | |
| Recruiting | 2 | 170 | Europe | Cannabisextrakt Avextra 10/10 Lösung, Cannabisextrakt Avextra 10/10 solution | University Hospital Schleswig-Holstein, Avextra Pharma GmbH, SocraMetrics GmbH | Medical Oncology, Palliative Care, Quality of Life, Cannabinoids | 11/26 | 11/26 | | |
TARC, NCT04177602: Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer - The Phase I/II Trial |
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| Terminated | 1/2 | 10 | Europe | Trifluridine/tipiracil chemoradiation, Capecitabine based chemoradiation | Universitätsklinikum Hamburg-Eppendorf, Clinical Trial Center North (CTC North GmbH & Co. KG), Servier Affaires Médicales | Locally Advanced Rectal Cancer | 09/22 | 09/22 | | |
COVIDOUT, NCT04779346: Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 Disease (COVID-19) in the Oncology Outpatient Setting |
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| Recruiting | N/A | 500 | Europe | | Universitätsklinikum Hamburg-Eppendorf | Cancer, Covid19, Immunity | 12/21 | 12/22 | | |
| Recruiting | N/A | 200 | Europe | Liquid Biopsy | Ludwig-Maximilians - University of Munich, Hoffmann-La Roche | Pancreas Cancer | 12/24 | 12/25 | | |
| Krug, Sebastian |
| Active, not recruiting | 2 | 45 | Europe | Cabozantinib | Karsten Gavenis | Neuroendocrine Tumors, Neuroendocrine Carcinoma | 09/24 | 10/24 | | |
| Completed | N/A | 400 | Europe | FoundationOne®CDx and FoundationOne®Liquid | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, Roche Pharma AG | Hepatocellular Cancer, Cholangiocarcinoma, Gallbladder Cancer, Pancreatic Cancer, Oesophageal Cancer, Stomach Cancer | 08/24 | 08/24 | | |
| Active, not recruiting | N/A | 1000 | Europe | | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | Hepatocellular Cancer, Cholangiocarcinoma, Gallbladder Cancer, Pancreatic Cancer, Oesophageal Cancer, Stomach Cancer | 05/32 | 05/32 | | |
| Perch, Michael |
NCT04714801: Adipose Derived Mesenchymal Cell Treatment in Lungtransplantation |
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| Recruiting | 1/2 | 30 | Europe | adipose derived mesenchymal stromal cells, CSCC_ASC, Saline | Rigshospitalet, Denmark | Lung Transplant Rejection | 11/23 | 11/24 | | |
NCT06035120: An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients with Severe Emphysema |
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| Recruiting | N/A | 200 | Europe, US, RoW | AeriSeal System | Pulmonx Corporation | Emphysema, Pulmonary, Emphysema or COPD | 06/27 | 03/28 | | |
| Recruiting | N/A | 80 | Europe, RoW | Extracorporeal Photopheresis | Medical University of Vienna | Antibody-mediated Rejection, Lung Transplant Rejection | 03/27 | 06/27 | | |
| Reuter, Uwe |
| Completed | 2 | 101 | Europe | Erenumab, AMG 334, Placebo | Charite University, Berlin, Germany | Cluster Headache, Trigeminal Autonomic Cephalalgias, Headache Disorders, Primary, Brain Disease | 09/23 | 09/23 | | |
| Stein, Alexander |
| Completed | 3 | 430 | Europe | Ramucirumab, TAS 102 | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, Eli Lilly and Company, Trium Analysis Online GmbH | Colorectal Cancer | 07/24 | 07/24 | | |
TRAP-BTC, NCT06178445: Efficacy and Safety of GemCis Plus Trastuzumab Plus Pembrolizumab in Previously Untreated HER2-positive Biliary Tract Cancer |
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| Recruiting | 2 | 24 | Europe | SOC plus trastuzumab and pembrolizumab | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, Medizinische Hochschule Hannover, Germany, Prof. Dr. Arndt Vogel, MSD Sharp & Dohme GmbH, Germany | Biliary Tract Cancer, HER2 Gene Mutation | 07/26 | 04/28 | | |
| Recruiting | 2 | 48 | Europe | Binimetinib, Encorafenib, Cetuximab | AIO-Studien-gGmbH, Pierre Fabre Pharma GmbH, Merck Serono GmbH, Germany, Universitätsklinikum Hamburg-Eppendorf | Colorectal Cancer, Colon Cancer, BRAF V600E, BRAF V600 Mutation, Localized Cancer | 07/24 | 01/25 | | |
FUTURE, NCT06722183: Futibatinib in Combination With (Chemo)Immunotherapy in Colorectal Cancer and Other Solid Tumor Entities |
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| Not yet recruiting | 2 | 33 | Europe | Futibatinib orally administered, Tislelizumab (i.v. 200mg) | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, Universitätsmedizin Mainz, I. Medizinische Klinik, Forschungslabor Prof. Möhler | Colorectal Cancer | 06/27 | 06/27 | | |
TARC, NCT04177602: Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer - The Phase I/II Trial |
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| Terminated | 1/2 | 10 | Europe | Trifluridine/tipiracil chemoradiation, Capecitabine based chemoradiation | Universitätsklinikum Hamburg-Eppendorf, Clinical Trial Center North (CTC North GmbH & Co. KG), Servier Affaires Médicales | Locally Advanced Rectal Cancer | 09/22 | 09/22 | | |
NCT06123468: Study Evaluating Treatment of Sacituzumab-govitecan for Patients With Metastatic Esophagogastric Adenocarcinoma |
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| Active, not recruiting | 1/2 | 56 | Europe | Sacituzumab govitecan, Trodelvy | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, Gilead Sciences | Esophagogastric Adenocarcinoma | 02/27 | 03/27 | | |
| Active, not recruiting | N/A | 1000 | Europe | | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | Hepatocellular Cancer, Cholangiocarcinoma, Gallbladder Cancer, Pancreatic Cancer, Oesophageal Cancer, Stomach Cancer | 05/32 | 05/32 | | |
| Nguyen, Phan Anh Tuan |
NCT06035120: An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients with Severe Emphysema |
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| Recruiting | N/A | 200 | Europe, US, RoW | AeriSeal System | Pulmonx Corporation | Emphysema, Pulmonary, Emphysema or COPD | 06/27 | 03/28 | | |
| Darwiche, Kaid |
NCT03727568: Study Comparing Two Different Methods of Cryobiopsy in the Interstitial Lung Diseases |
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| Active, not recruiting | N/A | 140 | Europe | Cryobiopsy | University Hospital, Essen, Marta Cuyás | Interstitial Lung Disease | 05/22 | 12/22 | | |
| Completed | N/A | 102 | Europe, RoW | AeriSeal, Zephyr Valves, Bronchoscopic Lung Volume Reduction (BLVR), Zephyr System | Pulmonx Corporation | Emphysema, COPD, Severe Emphysema | 10/23 | 10/24 | | |
NCT06035120: An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients with Severe Emphysema |
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| Recruiting | N/A | 200 | Europe, US, RoW | AeriSeal System | Pulmonx Corporation | Emphysema, Pulmonary, Emphysema or COPD | 06/27 | 03/28 | | |
RheSolve, NCT04677465: Clinical Study of the RheOx Bronchial Rheoplasty System in Treating the Symptoms of Chronic Bronchitis |
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| Active, not recruiting | N/A | 270 | Europe, US | RheOx Bronchial Rheoplasty, Sham Procedure | Gala Therapeutics, Inc. | Chronic Bronchitis | 05/24 | 10/25 | | |
| Recruiting | N/A | 300 | Europe | Bronchoscopic Thermal Vapor Ablation, BTVA, InterVapor | Uptake Medical Technology, Inc. | Emphysema or COPD | 12/27 | 12/30 | | |
NCT05717192: BENTO - Bronchoscopic Lung Volume Reduction in Severe Emphysema Using Thermoablation |
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| Recruiting | N/A | 224 | Europe | InterVapor®-System | IHF GmbH - Institut für Herzinfarktforschung | Emphysema or Chronic Obstructive Pulmonary Disease | 04/26 | 12/27 | | |
| Wiggermann, Philipp |
#HOPE4LIVER, NCT04573881: The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy ( EU/UK) |
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| Active, not recruiting | N/A | 24 | Europe | HistoSonics System, Histotripsy | HistoSonics, Inc. | Liver Neoplasms, Hepatocellular Carcinoma, Liver Metastases | 09/22 | 07/26 | | |
| Recruiting | N/A | 250 | Europe | CLINIPORATOR | Cardiovascular and Interventional Radiological Society of Europe | Primary Liver Cancer, Secondary Liver Cancer | 01/26 | 01/27 | | |
| Bernig, Toralf |
| Recruiting | 3 | 167 | Europe | Temozolomide + Valproic Acid | University of Göttingen, Deutsche Kinderkrebsstiftung, Hannover Medical School | Glioblastoma WHO Grade IV, Diffuse Midline Glioma Histone 3 K27M WHO Grade IV, Anaplastic Astrocytoma WHO Grade III, Diffuse Intrinsic Pontine Glioma, Gliomatosis Cerebri | 12/23 | 12/23 | | |
| Recruiting | 2/3 | 1800 | Europe, Canada, RoW | VP16, Etoposide, TBI, Thiotepa, Thio, Treosulfan, Treo, Fludarabine, Flu, Busulfan, Bu, ATG Thymoglobulin, ATG Thymo, Cyclophosphamide, Cy, Grafalon, Anti-human T-lymphocyte immunoglobulin | St. Anna Kinderkrebsforschung, ALL SCTped Forum, European Society for Blood and Marrow Transplantation, ALL-BFM Study Group, Assistance Publique - Hôpitaux de Paris, Dutch Childhood Oncology Group, Swiss Pediatric Oncology Group, Australian & New Zealand Children's Haematology/Oncology Group | Acute Lymphoblastic Leukaemia | 06/25 | 04/30 | | |
| Biedermann, Luc |
| Recruiting | 3 | 612 | Europe, Canada, US, RoW | ABX464, Obefazimod, Placebo | Abivax S.A. | Ulcerative Colitis | 03/25 | 04/25 | | |
| Recruiting | 3 | 1050 | Europe, Canada, Japan, US, RoW | ABX464, Obefazimod, Placebo | Abivax S.A. | Ulcerative Colitis | 01/26 | 01/30 | | |
| Recruiting | 3 | 1063 | Europe, Canada, Japan, US, RoW | Mirikizumab, LY3074828 | Eli Lilly and Company | Ulcerative Colitis | 07/26 | 12/27 | | |
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NCT05488405: Mesalazine Oral Suspension in Active Eosinophilic Esophagitis |
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| Completed | 2a | 5 | Europe | Mesalamine Oral Product, 5-ASA | Dr. Falk Pharma GmbH | Eosinophilic Esophagitis | 06/23 | 07/23 | | |
NCT06233461: A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease |
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| Recruiting | 2 | 268 | Europe, Canada, Japan, US, RoW | TAK-279, Zasocitinib, Placebo | Takeda | Crohn's Disease | 09/26 | 07/27 | | |
NCT06254950: A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis |
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| Recruiting | 2 | 207 | Europe, Canada, Japan, US, RoW | TAK-279, Zasocitinib, Placebo | Takeda | Ulcerative Colitis | 09/26 | 08/27 | | |
| Not yet recruiting | N/A | 40 | NA | EG-760Z endoscope by Fujifilm | University of Zurich | Eosinophilic Esophagitis | 09/21 | 11/21 | | |
NCT05800704: Support of Colonization Resistance of the Gut Microbiota with the Synbiotic Food Supplement Nagasin® |
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| Recruiting | N/A | 49 | Europe | Nagasin, maltodextrin | University of Zurich, Insel Gruppe AG, University Hospital Bern, Stadtspital Zürich, Kantonsspital Winterthur KSW, Luzerner Kantonsspital, Cantonal Hosptal, Baselland | C. Difficile Enteritis | 03/25 | 03/25 | | |
| Powell, Sheila |
| Recruiting | 3 | 350 | Europe, Canada, US, RoW | Selinexor, KPT-330, Placebo, Ruxolitinib | Karyopharm Therapeutics Inc | Myelofibrosis | 09/25 | 03/28 | | |
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| Caballer, Jaime Sanz |
ROCKnrol-1, NCT06143891: A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease. |
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| Recruiting | 3 | 260 | Europe, Canada, US, RoW | Belumosudil, SAR445761/ KD025, REZUROCK, Placebo, Prednisone, Prednisolone | Sanofi | Chronic Graft Versus Host Disease | 09/28 | 09/28 | | |
| Active, not recruiting | 3 | 249 | Europe, Japan, US, RoW | mocravimod | Priothera SAS, Priothera S.A.S. | Adult Acute Myeloid Leukemia | 11/25 | 11/25 | | |
NCT04232241: Matched Unrelated vs. Haploidentical Donor for Allogeneic Stem Cell Transplantation in Patients With Acute Leukemia |
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| Recruiting | 2 | 440 | Europe, RoW | Allogeneic Stem Cell Transplantation | Universitätsklinikum Hamburg-Eppendorf, DKMS Stiftung Leben Spenden, Clinical Trial Center North (CTC North GmbH & Co. KG) | Acute Myeloid Leukemia in Remission, Acute Lymphoblastic Leukemia in Remission, Myelodysplastic Syndromes | 11/22 | 11/24 | | |
PHOEBUS, NCT05762211: Oral Pooled Fecal Microbiotherapy to Prevent Allogeneic Hematopoietic Cell Transplantation Complications ( Trial) |
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| Recruiting | 2 | 387 | Europe | Pooled allogeneic fecal microbiotherapy, MaaT033, Placebo | MaaT Pharma | Transplant Complication | 10/26 | 02/27 | | |
| Robles, Maria Camprubi |
| Recruiting | 3 | 225 | Europe, Canada, Japan, US, RoW | Olorofim, Olorofim (F901318), AmBisome®, AmBisome® (liposomal amphotericin B) | F2G Biotech GmbH, Iqvia Pty Ltd, Shionogi | Invasive Aspergillosis | 09/25 | 11/26 | | |
| Recruiting | 3 | 322 | Europe, Canada, US | Crenolanib, Crenolanib besylate, Cytarabine, Mitoxantrone, Placebo Oral Tablet, Fludarabine, Idarubicin, G-CSF | Arog Pharmaceuticals, Inc. | Relapsed/Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations | 10/24 | 10/24 | | |
| Active, not recruiting | 3 | 249 | Europe, Japan, US, RoW | mocravimod | Priothera SAS, Priothera S.A.S. | Adult Acute Myeloid Leukemia | 11/25 | 11/25 | | |
| Terminated | 1/2 | 24 | Europe, US | Lanraplenib, LANRA, Gilteritinib, XOSPATA® | Kronos Bio, Kronos Bio, Inc. | Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia | 04/24 | 04/24 | | |
AFM28-101, NCT05817058: First-in-Human Dose Escalation Study of AFM28 in Patients With Relapsed/Refractory Acute Myeloid Leukemia |
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| Recruiting | 1 | 30 | Europe | AFM28 | Affimed GmbH | Acute Myeloid Leukemia | 03/25 | 03/26 | | |
| Recruiting | N/A | 750 | Europe | PRI (Enhanced Recovery after surgery protocol) | Grupo Español de Rehabilitación Multimodal, Instituto de Salud Carlos III, Instituto de Investigación Sanitaria Aragón | Major Surgery | 09/22 | 09/25 | | |
NCT04737785: Central Nervous System Disorders Following Hematopoietic Stem Cell Transplantation |
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| Completed | N/A | 252 | Europe, RoW | | European Society for Blood and Marrow Transplantation | Central Nervous System Infections, Central Nervous System Complication, Infectious Disease of Nervous System, Blood Disease, Blood Cancer, Infection | 06/23 | 08/24 | | |
| Kali, Maher |
| Recruiting | 3 | 350 | Europe, Canada, US, RoW | Selinexor, KPT-330, Placebo, Ruxolitinib | Karyopharm Therapeutics Inc | Myelofibrosis | 09/25 | 03/28 | | |
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| Kovacs, Attila |
| Recruiting | N/A | 250 | Europe | CLINIPORATOR | Cardiovascular and Interventional Radiological Society of Europe | Primary Liver Cancer, Secondary Liver Cancer | 01/26 | 01/27 | | |
| Saibeni, Simone |
| Recruiting | 3 | 612 | Europe, Canada, Japan, US, RoW | ABX464, Obefazimod, Placebo | Abivax S.A. | Ulcerative Colitis | 03/25 | 04/25 | | |
LUCENT-URGE, NCT05767021: A Study of Mirikizumab (LY3074828) in Participants With Moderately to Severely Active Ulcerative Colitis |
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| Active, not recruiting | 3 | 160 | Europe, US, RoW | Mirikizumab, LY3074828 | Eli Lilly and Company | Ulcerative Colitis, Ulcerative Colitis Chronic | 08/24 | 09/25 | | |
| Recruiting | 3 | 778 | Europe, Canada, Japan, US, RoW | Mirikizumab, LY3074828 | Eli Lilly and Company | Crohn's Disease | 11/24 | 12/26 | | |
| Recruiting | 3 | 1050 | Europe, Canada, Japan, US, RoW | ABX464, Obefazimod, Placebo | Abivax S.A. | Ulcerative Colitis | 01/26 | 01/30 | | |
| Recruiting | 3 | 1063 | Europe, Canada, Japan, US, RoW | Mirikizumab, LY3074828 | Eli Lilly and Company | Ulcerative Colitis | 07/26 | 12/27 | | |
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| Active, not recruiting | N/A | 72 | Europe, Canada, RoW | No Intervention | Takeda | Crohn's Disease | 10/25 | 10/25 | | |
| Walldorf, Jens |
FRESCO, NCT03843385: Transfer of FRozen Encapsulated Multidonor Stool Filtrate for Active Ulcerative COlitis |
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| Recruiting | 3 | 174 | Europe | encapsulated faecal microbiota filtrate, FMFT, encapsulated faecal microbiota, FMT, Placebo, Encapsulated sterile saline | Andreas Stallmach, German Federal Ministry of Education and Research | Ulcerative Colitis, Inflammatory Bowel Diseases | 01/25 | 07/26 | | |
LUCENT-URGE, NCT05767021: A Study of Mirikizumab (LY3074828) in Participants With Moderately to Severely Active Ulcerative Colitis |
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| Active, not recruiting | 3 | 160 | Europe, US, RoW | Mirikizumab, LY3074828 | Eli Lilly and Company | Ulcerative Colitis, Ulcerative Colitis Chronic | 08/24 | 09/25 | | |
| Recruiting | 3 | 1063 | Europe, Canada, Japan, US, RoW | Mirikizumab, LY3074828 | Eli Lilly and Company | Ulcerative Colitis | 07/26 | 12/27 | | |
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| Schulze, Susann |
| Recruiting | N/A | 1100 | Europe | | Jena University Hospital, University Hospital Dresden, Novartis, Swedish Orphan Biovitrum, Grifols Biologicals, LLC, Amgen, argenx | Immune Thrombocytopenia | 09/26 | 04/27 | | |
| Binder, Mascha |
NCT05008809: Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418) |
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| Recruiting | 3 | 507 | Europe | mFOLFOX6, Folinic acid, Oxaliplatin, 5-fluorouracil (FU), mFOLFOXIRI, Folinic acid, Oxaliplatin, 5-FU, Irinotecan, FOLFIRI, Folinic acid, 5-FU, CAPOX, Capecitaine, Oxaliplatin | Dominik Paul Modest, German Research Foundation, Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | Colorectal Cancer | 11/27 | 11/30 | | |
FOCUS, NCT05075122 / 2020-005910-17: Tolerability and Efficacy of UV1 Vaccine in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Planned for First-line Treatment With Pembrolizumab |
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| Recruiting | 2 | 75 | Europe | UV1, Sargramostim for Injection, Pembrolizumab injection | Martin-Luther-Universität Halle-Wittenberg, Ultimovacs ASA, Apotheke der Universitätsmedizin der Johannes Gutenberg-Universität Mainz (Germany), Axel Hinke. CCRC Cancer Clinical Research Consulting (Düsseldorf, Germany | Head and Neck Squamous Cell Carcinoma | 08/24 | 02/25 | | |
TARC, NCT04177602: Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer - The Phase I/II Trial |
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| Terminated | 1/2 | 10 | Europe | Trifluridine/tipiracil chemoradiation, Capecitabine based chemoradiation | Universitätsklinikum Hamburg-Eppendorf, Clinical Trial Center North (CTC North GmbH & Co. KG), Servier Affaires Médicales | Locally Advanced Rectal Cancer | 09/22 | 09/22 | | |
