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 79 Trials 
61 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Vaezi, Michael F
NCT03103789: Assessment of Esophageal Epithelium Integrity With Use of a Novel Mucosal Impedance Device

Enrolling by invitation
N/A
75
US
single catheter mucosal impedance testing, balloon assembly mucosal impedance testing
Vanderbilt University Medical Center, Sandhill Scientific
Gastro Esophageal Reflux
08/25
08/25
Johnson, Julia V
stAAAble, NCT06001918: Nectero EAST System Clinical Study

Suspended
2/3
400
US, RoW
Nectero EAST System
Nectero Medical, Inc.
Abdominal Aortic Aneurysm
03/27
12/29
ACTIVATE, NCT05819359: Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

Active, not recruiting
2
237
Europe, Canada, US
BIA 28-6156 10 mg, BIA 28-6156 60 mg, Placebo
Bial R&D Investments, S.A.
Parkinson's Disease
03/26
07/26
Obremskey, William T
FROST, NCT03598530: Fracture-Related Outcome Study for Operatively Treated Tibia Shaft Fractures

Active, not recruiting
N/A
1000
Europe, US, RoW
Surgery, Operative, Surgical treatment
AO Clinical Investigation and Publishing Documentation, DePuy Synthes
Tibial Fracture, Fracture of the Tibia Type AO/OTA 42
03/25
12/25
Kuhn, John E
MOON, NCT00762580: Features to Predict Success With Nonoperative Treatment of Patients With Rotator Cuff Tears

Completed
N/A
452
US
Vanderbilt University, University of Colorado, Denver, Ohio State University, University of Iowa, University of California, San Francisco, Arthrex, Inc., Knoxville Orthopedic Clinic, Washington University School of Medicine, Sports Medicine and Shoulder Surgery Orthopedic Institute, Hospital for Special Surgery, New York
Rotator Cuff Tear
01/24
01/24
Piana, Robert N
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
REDUCE PAS, NCT03821129: GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Recruiting
N/A
636
US
PFO closure with GORE® CARDIOFORM Septal Occluder
W.L.Gore & Associates
Stroke, PFO - Patent Foramen Ovale
10/28
10/31
Phibbs, Fenna T
ACTIVATE, NCT05819359: Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

Active, not recruiting
2
237
Europe, Canada, US
BIA 28-6156 10 mg, BIA 28-6156 60 mg, Placebo
Bial R&D Investments, S.A.
Parkinson's Disease
03/26
07/26
Yu, Chang
NCT05862337: Anlotinib Hydrochloride Capsules Combined With Penpulimab Injection for the Treatment of Hepatocellular Carcinoma at High Risk of Recurrence.

Recruiting
3
480
RoW
Anlotinib hydrochloride capsules, Penpulimab injection, Anlotinib hydrochloride capsules -matching placebo, Penpulimab injection -matching placebo
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Hepatocellular Carcinoma
08/24
12/26
NCT06310590: Safety and Efficacy of TareSphere in Patients with Unresectable Hepatocellular Carcinoma

Active, not recruiting
1
40
RoW
NRT6003 Injection, Yttrium-90 carbon microspheres
Chengdu New Radiomedicine Technology Co. LTD.
Unresectable Hepatocellular Carcinoma
10/25
12/25
Kimmelstiel, Carey
DTU-STEMI, NCT03947619: Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: the STEMI-DTU Trial

Active, not recruiting
N/A
527
Europe, Canada, US
Impella CP® placement prior to reperfusion with Primary PCI
Abiomed Inc.
ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
09/24
10/30
CATALYST, NCT04226547: Amplatzer Amulet LAAO Vs. NOAC

Recruiting
N/A
2650
Europe, Canada, Japan, US, RoW
Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC
Abbott Medical Devices
Atrial Fibrillation, Stroke, Bleeding
08/27
08/30
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
LeWitt, Peter
NCT05979415: Study to Evaluate the Efficacy and Safety of Staccato Apomorphine (AZ-009) in Patients With Parkinson's Disease Experiencing OFF Episodes

Terminated
2
8
US
Apomorphine Cartridge, placebo
Alexza Pharmaceuticals, Inc., Peachtree BioResearch Solutions, DSG, ISS, Inc.
Parkinson Disease
02/24
02/24
NCT03655236: PROSEEK: A Phase 2 Study In Early Parkinson's Disease Patients Evaluating The Safety And Efficacy Of Abl Tyrosine Kinase Inhibition Using K0706

Terminated
2
513
Europe, US, RoW
K0706, placebo
Sun Pharma Advanced Research Company Limited
Early Parkinson Disease
04/24
06/24
ACTIVATE, NCT05819359: Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

Active, not recruiting
2
237
Europe, Canada, US
BIA 28-6156 10 mg, BIA 28-6156 60 mg, Placebo
Bial R&D Investments, S.A.
Parkinson's Disease
03/26
07/26
NCT05958030: GyroGlove Use in Essential Tremor Patients

Not yet recruiting
N/A
30
Europe, US
Placebo, GyroGlove
GyroGear Ltd
Essential Tremor
10/25
12/25
NCT06219629: Parkinson's Disease Progression Study

Active, not recruiting
N/A
82
US
Koneksa Health, Merck Sharp & Dohme LLC, Regeneron Pharmaceuticals
Parkinson Disease
02/26
02/26
Konda, Sanjit
FROST, NCT03598530: Fracture-Related Outcome Study for Operatively Treated Tibia Shaft Fractures

Active, not recruiting
N/A
1000
Europe, US, RoW
Surgery, Operative, Surgical treatment
AO Clinical Investigation and Publishing Documentation, DePuy Synthes
Tibial Fracture, Fracture of the Tibia Type AO/OTA 42
03/25
12/25
Yang, Joanna
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
Maldonado, Fabien
LuTK02, NCT04495153: CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC

Active, not recruiting
2
90
US
Aglatimagene besadenovec, CAN-2409, AdV-tk
Candel Therapeutics, Inc., NYU Langone Health
Non Small Cell Lung Cancer
12/24
12/26
RheSolve, NCT04677465: Clinical Study of the RheOx Bronchial Rheoplasty System in Treating the Symptoms of Chronic Bronchitis

Active, not recruiting
N/A
270
Europe, US
RheOx Bronchial Rheoplasty, Sham Procedure
Gala Therapeutics, Inc.
Chronic Bronchitis
05/24
10/25
VERITAS, NCT04250194: Navigation Endoscopy to Reach Indeterminate Lung Nodules Versus Trans-Thoracic Needle Aspiration

Active, not recruiting
N/A
256
US
CT-Guided Biopsy, Navigation bronchoscopy
Vanderbilt-Ingram Cancer Center, Medtronic
Lung Nodule
06/24
07/25
Lenihan, Daniel J
NCT01311843: Effectiveness of Using Biomarkers to Detect and Identify Cardiotoxicity and Describe Treatment (PREDICT)

Active, not recruiting
N/A
830
US
Questionnaire, Survey, MDASI, M. D. Anderson Symptom Index - Heart Failure, MDASI-HF
M.D. Anderson Cancer Center, Alere San Diego
Breast Cancer, Gastrointestinal Cancer, Genitourinary Cancer, Leukemia, Lung Cancer
01/26
 
Robbins, Ivan M
IMPAHCT-FUL, NCT05557942 / 2021-006864-25: Inhaled Imatinib Pulmonary Arterial Hypertension Clinical Trial - Follow Up Long Term Extension

Terminated
3
186
Europe, Canada, US, RoW
AV-101
Aerovate Therapeutics, Aerovate Therapeutics Inc
Pulmonary Arterial Hypertension
08/24
08/24
IMPAHCT, NCT05036135 / 2021-001910-13: A Study of AV-101 (Dry Powder Inhaled Imatinib) in Patients With Pulmonary Arterial Hypertension (PAH)

Terminated
2/3
202
Europe, Canada, US, RoW
AV-101, Placebo
Aerovate Therapeutics, Aerovate Therapeutics, Inc.
Pulmonary Arterial Hypertension
08/24
08/24
ELEVATE 2, NCT04712669 / 2020-004971-42: A Study of Rodatristat Ethyl in Patients With Pulmonary Arterial Hypertension

Completed
2
108
Europe, Canada, US, RoW
rodatristat ethyl 300 mg tablet BID, rodatristat ethyl 600 mg BID, Placebo
Altavant Sciences GmbH
Pulmonary Arterial Hypertension
06/23
08/23
NCT04469842: Early Use of Long-acting Tacrolimus in Lung Transplant Recipients

Recruiting
1
48
US
Tacrolimus Extended Release Oral Tablet [Envarsus], Envarsus XR, Tacrolimus, Intermediate Release Tacrolimus, Prograf, FK506, Mycophenolate Mofetil Hydrochloride, MMF, CellCept, Prednisone, Deltasone, Azathioprine, Imuran
Vanderbilt University Medical Center, Veloxis Pharmaceuticals
Lung Transplant; Complications
06/26
12/26
Shah, Ashish
REVERSE-IT, NCT04286438 / 2019-004457-92: Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

Completed
3
226
Europe, Canada, US, RoW
Bentracimab (PB2452) Infusion
SFJ Pharmaceuticals, Inc.
Hemorrhage, Urgent Surgery, Invasive Procedure
09/24
09/24
NCT06264388: DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma

Recruiting
2
33
US
DB107-RRV, DB107-FC, Ancobon, Ancotil
Ashish Shah, Denovo Biopharma LLC, National Cancer Institute (NCI)
High Grade Glioma, Anaplastic Astrocytoma
05/34
05/34
STARLITE, NCT06428045: for Unresectable High-Grade Gliomas

Not yet recruiting
1
24
US
Magnetic Resonance (MR)-guided Laser Interstitial Thermal Therapy (LITT), MR-Guided LITT, Abacavir, Lamivudine, Ritonavir, Norvir, RTV, Temozolomide, TMZ, Focal Radiotherapy
University of Miami, Medtronic
High Grade Glioma
07/29
07/30
NCT03780452: Compression Nail for Tibiocalcaneal Arthrodesis

Completed
N/A
30
US
novel dynamic compression intramedullary nail
University of Alabama at Birmingham, MedShape, Inc
Subtalar Arthritis, Ankle Arthritis
07/24
07/24
NCT05047068: OCS Heart Perfusion Post-Approval Registry

Active, not recruiting
N/A
350
US
OCS Heart System
TransMedics
Transplant
12/25
12/29
NCT05881278: XVIVO Heart Perfusion System (XHPS) With Supplemented XVIVO Heart Solution (SXHS)

Active, not recruiting
N/A
141
US
Non-Ischemic Heart Preservation (NIHP) using the XVIVO Heart Preservation System (XHPS)
XVIVO Perfusion
Heart Failure, Transplant; Failure, Heart
11/25
11/29
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
NCT04784273: The Use of a Dynamic Compression Intramedullary Nail for Tibiotalocalcaneal Arthrodesis

Recruiting
N/A
30
US
Tibiotalocalcaneal Arthrodesis, DynaNail
MedShape, Inc, University of Alabama at Birmingham
Ankle Arthritis, Foot Arthritis
09/23
09/23
Bowman, Sherry
FUEL-2, NCT05918211: Fontan Udenafil Exercise Longitudinal Assessment Trial - 2

Recruiting
3
436
US, RoW
Udenafil, Placebo
Mezzion Pharma Co. Ltd
Single Ventricle Heart Disease
10/25
10/25
AVANT GUARD, NCT06096337: Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation

Active, not recruiting
N/A
484
Europe, Canada, US, RoW
FARAPULSE™ Pulsed Field Ablation (PFA) System, Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone
Boston Scientific Corporation
Persistent Atrial Fibrillation
02/26
12/27
ACCESS MANTA, NCT05936996: Prospective Clinical Registry Evaluating Contemporary MANTA Outcomes

Recruiting
N/A
250
Canada, US
MANTA Vascular Closure Device
Essential Medical, Inc., Vascular Solutions LLC, Teleflex Medical Inc
Femoral Arteriotomy Closure
07/25
07/25
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study

Recruiting
N/A
400
Europe, US, RoW
AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy
Ancora Heart, Inc.
Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
12/26
12/30
NCT05905835: Treatment of PAF With the Synaptic System

Recruiting
N/A
185
US
Synaptic Cryoablation System
Synaptic Medical Corporation
Paroxysmal Atrial Fibrillation
07/24
12/24
ADVENT PAS, NCT06431815: ADVENT Post Approval Study

Recruiting
N/A
220
Canada, US, RoW
FARAPULSE™ Pulsed Field Ablation System, FARAWAVE™ Pulsed Field Ablation Catheter
Boston Scientific Corporation
Paroxysmal Atrial Fibrillation
10/28
10/29
ABT-CIP-10523, NCT06707688: Abbott Medical - VERITAS Study

Recruiting
N/A
475
Europe, Canada, US
Amulet™ 2 Left Atrial Appendage (LAA) Occluder
Abbott Medical Devices
Atrial Fibrillation (AF), Stoke
07/26
07/28
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
Slinger, Lisa
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
11/24
10/29
NCT05047068: OCS Heart Perfusion Post-Approval Registry

Active, not recruiting
N/A
350
US
OCS Heart System
TransMedics
Transplant
12/25
12/29
NCT05881278: XVIVO Heart Perfusion System (XHPS) With Supplemented XVIVO Heart Solution (SXHS)

Active, not recruiting
N/A
141
US
Non-Ischemic Heart Preservation (NIHP) using the XVIVO Heart Preservation System (XHPS)
XVIVO Perfusion
Heart Failure, Transplant; Failure, Heart
11/25
11/29
Sanders, Rosemary A
BEAR-MOON, NCT03776162: A Comparison of ACL Repair With BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction

Recruiting
N/A
200
US
ACL Reconstruction (Bone Patellar Tendon Bone Graft), Bridge Enhanced ACL Restoration (BEAR)
The Cleveland Clinic, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Miach Orthopaedics
Anterior Cruciate Ligament Tear
05/27
05/27
Isaacs, David A
EBS-101-TD-391, NCT06021522: A Study to Evaluate Long-term Safety of Ecopipam Tablets in Children, Adolescents and Adults With Tourette's Disorder

Recruiting
3
150
Europe, Canada, US, RoW
Ecopipam, Ecopipam Hydrochloride
Emalex Biosciences Inc.
Tourette Syndrome
11/24
03/27
D1AMOND, NCT05615220: Ecopipam Tablets to Study Tourette's Disorder in Children, Adolescents and Adults

Active, not recruiting
3
196
Europe, Canada, US, RoW
Ecopipam Hydrochloride
Emalex Biosciences Inc.
Tourette Disorder
12/24
12/24
NCT03417583: Assessing Efficacy of Neuropsychiatric Assessment and Treatment Protocols in Huntington's Disease Patients

Completed
N/A
100
US
Protocol Intervention Group
Vanderbilt University Medical Center, Teva Pharmaceuticals USA
Huntington Disease
01/23
10/23
Englot, Dario
NCT05882344: Cholinergic Deep Brain Stimulation for Alzheimer's Disease

Not yet recruiting
N/A
2
US
Device Implantation- Boston Scientific, VERCISE GENUS™ system, DBS Stimulation - Boston Scientific, VERCISE GENUS™ system
Vanderbilt University Medical Center, Boston Scientific Corporation
Alzheimer Disease, Early Onset, Dementia, Alzheimer Disease
10/28
10/28
Harris, Jackie
ACTIVATE, NCT05819359: Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

Active, not recruiting
2
237
Europe, Canada, US
BIA 28-6156 10 mg, BIA 28-6156 60 mg, Placebo
Bial R&D Investments, S.A.
Parkinson's Disease
03/26
07/26
Stefanescu, Ada
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
Kerrigan, Deborah
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction

Terminated
3
535
Europe, Canada, Japan, US, RoW
BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo
Remedy Pharmaceuticals, Inc.
Brain Edema, Stroke, Acute
08/23
08/23
Savica, Rodolfo
ACTIVATE, NCT05819359: Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

Active, not recruiting
2
237
Europe, Canada, US
BIA 28-6156 10 mg, BIA 28-6156 60 mg, Placebo
Bial R&D Investments, S.A.
Parkinson's Disease
03/26
07/26
Blake, Dave
NCT05882344: Cholinergic Deep Brain Stimulation for Alzheimer's Disease

Not yet recruiting
N/A
2
US
Device Implantation- Boston Scientific, VERCISE GENUS™ system, DBS Stimulation - Boston Scientific, VERCISE GENUS™ system
Vanderbilt University Medical Center, Boston Scientific Corporation
Alzheimer Disease, Early Onset, Dementia, Alzheimer Disease
10/28
10/28
Suell, Chrissy
NCT05882344: Cholinergic Deep Brain Stimulation for Alzheimer's Disease

Not yet recruiting
N/A
2
US
Device Implantation- Boston Scientific, VERCISE GENUS™ system, DBS Stimulation - Boston Scientific, VERCISE GENUS™ system
Vanderbilt University Medical Center, Boston Scientific Corporation
Alzheimer Disease, Early Onset, Dementia, Alzheimer Disease
10/28
10/28
Azimi, Sina
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Vaezi, Michael F
NCT03103789: Assessment of Esophageal Epithelium Integrity With Use of a Novel Mucosal Impedance Device

Enrolling by invitation
N/A
75
US
single catheter mucosal impedance testing, balloon assembly mucosal impedance testing
Vanderbilt University Medical Center, Sandhill Scientific
Gastro Esophageal Reflux
08/25
08/25
Johnson, Julia V
stAAAble, NCT06001918: Nectero EAST System Clinical Study

Suspended
2/3
400
US, RoW
Nectero EAST System
Nectero Medical, Inc.
Abdominal Aortic Aneurysm
03/27
12/29
ACTIVATE, NCT05819359: Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

Active, not recruiting
2
237
Europe, Canada, US
BIA 28-6156 10 mg, BIA 28-6156 60 mg, Placebo
Bial R&D Investments, S.A.
Parkinson's Disease
03/26
07/26
Obremskey, William T
FROST, NCT03598530: Fracture-Related Outcome Study for Operatively Treated Tibia Shaft Fractures

Active, not recruiting
N/A
1000
Europe, US, RoW
Surgery, Operative, Surgical treatment
AO Clinical Investigation and Publishing Documentation, DePuy Synthes
Tibial Fracture, Fracture of the Tibia Type AO/OTA 42
03/25
12/25
Kuhn, John E
MOON, NCT00762580: Features to Predict Success With Nonoperative Treatment of Patients With Rotator Cuff Tears

Completed
N/A
452
US
Vanderbilt University, University of Colorado, Denver, Ohio State University, University of Iowa, University of California, San Francisco, Arthrex, Inc., Knoxville Orthopedic Clinic, Washington University School of Medicine, Sports Medicine and Shoulder Surgery Orthopedic Institute, Hospital for Special Surgery, New York
Rotator Cuff Tear
01/24
01/24
Piana, Robert N
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
REDUCE PAS, NCT03821129: GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

Recruiting
N/A
636
US
PFO closure with GORE® CARDIOFORM Septal Occluder
W.L.Gore & Associates
Stroke, PFO - Patent Foramen Ovale
10/28
10/31
Phibbs, Fenna T
ACTIVATE, NCT05819359: Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

Active, not recruiting
2
237
Europe, Canada, US
BIA 28-6156 10 mg, BIA 28-6156 60 mg, Placebo
Bial R&D Investments, S.A.
Parkinson's Disease
03/26
07/26
Yu, Chang
NCT05862337: Anlotinib Hydrochloride Capsules Combined With Penpulimab Injection for the Treatment of Hepatocellular Carcinoma at High Risk of Recurrence.

Recruiting
3
480
RoW
Anlotinib hydrochloride capsules, Penpulimab injection, Anlotinib hydrochloride capsules -matching placebo, Penpulimab injection -matching placebo
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Hepatocellular Carcinoma
08/24
12/26
NCT06310590: Safety and Efficacy of TareSphere in Patients with Unresectable Hepatocellular Carcinoma

Active, not recruiting
1
40
RoW
NRT6003 Injection, Yttrium-90 carbon microspheres
Chengdu New Radiomedicine Technology Co. LTD.
Unresectable Hepatocellular Carcinoma
10/25
12/25
Kimmelstiel, Carey
DTU-STEMI, NCT03947619: Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: the STEMI-DTU Trial

Active, not recruiting
N/A
527
Europe, Canada, US
Impella CP® placement prior to reperfusion with Primary PCI
Abiomed Inc.
ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
09/24
10/30
CATALYST, NCT04226547: Amplatzer Amulet LAAO Vs. NOAC

Recruiting
N/A
2650
Europe, Canada, Japan, US, RoW
Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC
Abbott Medical Devices
Atrial Fibrillation, Stroke, Bleeding
08/27
08/30
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
LeWitt, Peter
NCT05979415: Study to Evaluate the Efficacy and Safety of Staccato Apomorphine (AZ-009) in Patients With Parkinson's Disease Experiencing OFF Episodes

Terminated
2
8
US
Apomorphine Cartridge, placebo
Alexza Pharmaceuticals, Inc., Peachtree BioResearch Solutions, DSG, ISS, Inc.
Parkinson Disease
02/24
02/24
NCT03655236: PROSEEK: A Phase 2 Study In Early Parkinson's Disease Patients Evaluating The Safety And Efficacy Of Abl Tyrosine Kinase Inhibition Using K0706

Terminated
2
513
Europe, US, RoW
K0706, placebo
Sun Pharma Advanced Research Company Limited
Early Parkinson Disease
04/24
06/24
ACTIVATE, NCT05819359: Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

Active, not recruiting
2
237
Europe, Canada, US
BIA 28-6156 10 mg, BIA 28-6156 60 mg, Placebo
Bial R&D Investments, S.A.
Parkinson's Disease
03/26
07/26
NCT05958030: GyroGlove Use in Essential Tremor Patients

Not yet recruiting
N/A
30
Europe, US
Placebo, GyroGlove
GyroGear Ltd
Essential Tremor
10/25
12/25
NCT06219629: Parkinson's Disease Progression Study

Active, not recruiting
N/A
82
US
Koneksa Health, Merck Sharp & Dohme LLC, Regeneron Pharmaceuticals
Parkinson Disease
02/26
02/26
Konda, Sanjit
FROST, NCT03598530: Fracture-Related Outcome Study for Operatively Treated Tibia Shaft Fractures

Active, not recruiting
N/A
1000
Europe, US, RoW
Surgery, Operative, Surgical treatment
AO Clinical Investigation and Publishing Documentation, DePuy Synthes
Tibial Fracture, Fracture of the Tibia Type AO/OTA 42
03/25
12/25
Yang, Joanna
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
Maldonado, Fabien
LuTK02, NCT04495153: CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC

Active, not recruiting
2
90
US
Aglatimagene besadenovec, CAN-2409, AdV-tk
Candel Therapeutics, Inc., NYU Langone Health
Non Small Cell Lung Cancer
12/24
12/26
RheSolve, NCT04677465: Clinical Study of the RheOx Bronchial Rheoplasty System in Treating the Symptoms of Chronic Bronchitis

Active, not recruiting
N/A
270
Europe, US
RheOx Bronchial Rheoplasty, Sham Procedure
Gala Therapeutics, Inc.
Chronic Bronchitis
05/24
10/25
VERITAS, NCT04250194: Navigation Endoscopy to Reach Indeterminate Lung Nodules Versus Trans-Thoracic Needle Aspiration

Active, not recruiting
N/A
256
US
CT-Guided Biopsy, Navigation bronchoscopy
Vanderbilt-Ingram Cancer Center, Medtronic
Lung Nodule
06/24
07/25
Lenihan, Daniel J
NCT01311843: Effectiveness of Using Biomarkers to Detect and Identify Cardiotoxicity and Describe Treatment (PREDICT)

Active, not recruiting
N/A
830
US
Questionnaire, Survey, MDASI, M. D. Anderson Symptom Index - Heart Failure, MDASI-HF
M.D. Anderson Cancer Center, Alere San Diego
Breast Cancer, Gastrointestinal Cancer, Genitourinary Cancer, Leukemia, Lung Cancer
01/26
 
Robbins, Ivan M
IMPAHCT-FUL, NCT05557942 / 2021-006864-25: Inhaled Imatinib Pulmonary Arterial Hypertension Clinical Trial - Follow Up Long Term Extension

Terminated
3
186
Europe, Canada, US, RoW
AV-101
Aerovate Therapeutics, Aerovate Therapeutics Inc
Pulmonary Arterial Hypertension
08/24
08/24
IMPAHCT, NCT05036135 / 2021-001910-13: A Study of AV-101 (Dry Powder Inhaled Imatinib) in Patients With Pulmonary Arterial Hypertension (PAH)

Terminated
2/3
202
Europe, Canada, US, RoW
AV-101, Placebo
Aerovate Therapeutics, Aerovate Therapeutics, Inc.
Pulmonary Arterial Hypertension
08/24
08/24
ELEVATE 2, NCT04712669 / 2020-004971-42: A Study of Rodatristat Ethyl in Patients With Pulmonary Arterial Hypertension

Completed
2
108
Europe, Canada, US, RoW
rodatristat ethyl 300 mg tablet BID, rodatristat ethyl 600 mg BID, Placebo
Altavant Sciences GmbH
Pulmonary Arterial Hypertension
06/23
08/23
NCT04469842: Early Use of Long-acting Tacrolimus in Lung Transplant Recipients

Recruiting
1
48
US
Tacrolimus Extended Release Oral Tablet [Envarsus], Envarsus XR, Tacrolimus, Intermediate Release Tacrolimus, Prograf, FK506, Mycophenolate Mofetil Hydrochloride, MMF, CellCept, Prednisone, Deltasone, Azathioprine, Imuran
Vanderbilt University Medical Center, Veloxis Pharmaceuticals
Lung Transplant; Complications
06/26
12/26
Shah, Ashish
REVERSE-IT, NCT04286438 / 2019-004457-92: Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

Completed
3
226
Europe, Canada, US, RoW
Bentracimab (PB2452) Infusion
SFJ Pharmaceuticals, Inc.
Hemorrhage, Urgent Surgery, Invasive Procedure
09/24
09/24
NCT06264388: DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma

Recruiting
2
33
US
DB107-RRV, DB107-FC, Ancobon, Ancotil
Ashish Shah, Denovo Biopharma LLC, National Cancer Institute (NCI)
High Grade Glioma, Anaplastic Astrocytoma
05/34
05/34
STARLITE, NCT06428045: for Unresectable High-Grade Gliomas

Not yet recruiting
1
24
US
Magnetic Resonance (MR)-guided Laser Interstitial Thermal Therapy (LITT), MR-Guided LITT, Abacavir, Lamivudine, Ritonavir, Norvir, RTV, Temozolomide, TMZ, Focal Radiotherapy
University of Miami, Medtronic
High Grade Glioma
07/29
07/30
NCT03780452: Compression Nail for Tibiocalcaneal Arthrodesis

Completed
N/A
30
US
novel dynamic compression intramedullary nail
University of Alabama at Birmingham, MedShape, Inc
Subtalar Arthritis, Ankle Arthritis
07/24
07/24
NCT05047068: OCS Heart Perfusion Post-Approval Registry

Active, not recruiting
N/A
350
US
OCS Heart System
TransMedics
Transplant
12/25
12/29
NCT05881278: XVIVO Heart Perfusion System (XHPS) With Supplemented XVIVO Heart Solution (SXHS)

Active, not recruiting
N/A
141
US
Non-Ischemic Heart Preservation (NIHP) using the XVIVO Heart Preservation System (XHPS)
XVIVO Perfusion
Heart Failure, Transplant; Failure, Heart
11/25
11/29
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
NCT04784273: The Use of a Dynamic Compression Intramedullary Nail for Tibiotalocalcaneal Arthrodesis

Recruiting
N/A
30
US
Tibiotalocalcaneal Arthrodesis, DynaNail
MedShape, Inc, University of Alabama at Birmingham
Ankle Arthritis, Foot Arthritis
09/23
09/23
Bowman, Sherry
FUEL-2, NCT05918211: Fontan Udenafil Exercise Longitudinal Assessment Trial - 2

Recruiting
3
436
US, RoW
Udenafil, Placebo
Mezzion Pharma Co. Ltd
Single Ventricle Heart Disease
10/25
10/25
AVANT GUARD, NCT06096337: Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation

Active, not recruiting
N/A
484
Europe, Canada, US, RoW
FARAPULSE™ Pulsed Field Ablation (PFA) System, Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone
Boston Scientific Corporation
Persistent Atrial Fibrillation
02/26
12/27
ACCESS MANTA, NCT05936996: Prospective Clinical Registry Evaluating Contemporary MANTA Outcomes

Recruiting
N/A
250
Canada, US
MANTA Vascular Closure Device
Essential Medical, Inc., Vascular Solutions LLC, Teleflex Medical Inc
Femoral Arteriotomy Closure
07/25
07/25
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study

Recruiting
N/A
400
Europe, US, RoW
AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy
Ancora Heart, Inc.
Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
12/26
12/30
NCT05905835: Treatment of PAF With the Synaptic System

Recruiting
N/A
185
US
Synaptic Cryoablation System
Synaptic Medical Corporation
Paroxysmal Atrial Fibrillation
07/24
12/24
ADVENT PAS, NCT06431815: ADVENT Post Approval Study

Recruiting
N/A
220
Canada, US, RoW
FARAPULSE™ Pulsed Field Ablation System, FARAWAVE™ Pulsed Field Ablation Catheter
Boston Scientific Corporation
Paroxysmal Atrial Fibrillation
10/28
10/29
ABT-CIP-10523, NCT06707688: Abbott Medical - VERITAS Study

Recruiting
N/A
475
Europe, Canada, US
Amulet™ 2 Left Atrial Appendage (LAA) Occluder
Abbott Medical Devices
Atrial Fibrillation (AF), Stoke
07/26
07/28
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
Slinger, Lisa
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
11/24
10/29
NCT05047068: OCS Heart Perfusion Post-Approval Registry

Active, not recruiting
N/A
350
US
OCS Heart System
TransMedics
Transplant
12/25
12/29
NCT05881278: XVIVO Heart Perfusion System (XHPS) With Supplemented XVIVO Heart Solution (SXHS)

Active, not recruiting
N/A
141
US
Non-Ischemic Heart Preservation (NIHP) using the XVIVO Heart Preservation System (XHPS)
XVIVO Perfusion
Heart Failure, Transplant; Failure, Heart
11/25
11/29
Sanders, Rosemary A
BEAR-MOON, NCT03776162: A Comparison of ACL Repair With BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction

Recruiting
N/A
200
US
ACL Reconstruction (Bone Patellar Tendon Bone Graft), Bridge Enhanced ACL Restoration (BEAR)
The Cleveland Clinic, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Miach Orthopaedics
Anterior Cruciate Ligament Tear
05/27
05/27
Isaacs, David A
EBS-101-TD-391, NCT06021522: A Study to Evaluate Long-term Safety of Ecopipam Tablets in Children, Adolescents and Adults With Tourette's Disorder

Recruiting
3
150
Europe, Canada, US, RoW
Ecopipam, Ecopipam Hydrochloride
Emalex Biosciences Inc.
Tourette Syndrome
11/24
03/27
D1AMOND, NCT05615220: Ecopipam Tablets to Study Tourette's Disorder in Children, Adolescents and Adults

Active, not recruiting
3
196
Europe, Canada, US, RoW
Ecopipam Hydrochloride
Emalex Biosciences Inc.
Tourette Disorder
12/24
12/24
NCT03417583: Assessing Efficacy of Neuropsychiatric Assessment and Treatment Protocols in Huntington's Disease Patients

Completed
N/A
100
US
Protocol Intervention Group
Vanderbilt University Medical Center, Teva Pharmaceuticals USA
Huntington Disease
01/23
10/23
Englot, Dario
NCT05882344: Cholinergic Deep Brain Stimulation for Alzheimer's Disease

Not yet recruiting
N/A
2
US
Device Implantation- Boston Scientific, VERCISE GENUS™ system, DBS Stimulation - Boston Scientific, VERCISE GENUS™ system
Vanderbilt University Medical Center, Boston Scientific Corporation
Alzheimer Disease, Early Onset, Dementia, Alzheimer Disease
10/28
10/28
Harris, Jackie
ACTIVATE, NCT05819359: Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

Active, not recruiting
2
237
Europe, Canada, US
BIA 28-6156 10 mg, BIA 28-6156 60 mg, Placebo
Bial R&D Investments, S.A.
Parkinson's Disease
03/26
07/26
Stefanescu, Ada
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26
Kerrigan, Deborah
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction

Terminated
3
535
Europe, Canada, Japan, US, RoW
BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo
Remedy Pharmaceuticals, Inc.
Brain Edema, Stroke, Acute
08/23
08/23
Savica, Rodolfo
ACTIVATE, NCT05819359: Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD

Active, not recruiting
2
237
Europe, Canada, US
BIA 28-6156 10 mg, BIA 28-6156 60 mg, Placebo
Bial R&D Investments, S.A.
Parkinson's Disease
03/26
07/26
Blake, Dave
NCT05882344: Cholinergic Deep Brain Stimulation for Alzheimer's Disease

Not yet recruiting
N/A
2
US
Device Implantation- Boston Scientific, VERCISE GENUS™ system, DBS Stimulation - Boston Scientific, VERCISE GENUS™ system
Vanderbilt University Medical Center, Boston Scientific Corporation
Alzheimer Disease, Early Onset, Dementia, Alzheimer Disease
10/28
10/28
Suell, Chrissy
NCT05882344: Cholinergic Deep Brain Stimulation for Alzheimer's Disease

Not yet recruiting
N/A
2
US
Device Implantation- Boston Scientific, VERCISE GENUS™ system, DBS Stimulation - Boston Scientific, VERCISE GENUS™ system
Vanderbilt University Medical Center, Boston Scientific Corporation
Alzheimer Disease, Early Onset, Dementia, Alzheimer Disease
10/28
10/28
Azimi, Sina
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion

Active, not recruiting
N/A
450
Europe, Canada, US
Investigational PFO Closure Device, Standard of Care PFO Closure Device
Occlutech International AB
Stroke, Patent Foramen Ovale, PFO
11/25
10/26

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