| Brem, Steven |
DCVax-L EAP, NCT02146066: Expanded Access Protocol for GBM Patients With Already Manufactured DCVax®-L Who Have Screen-Failed Protocol 020221 |
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| Available | N/A | | US | DCVax-L | Northwest Biotherapeutics | GBM, Glioblastoma Multiforme | | | | |
NCT02559401: Validation of Edema-invariant Multi-shell High Angular Resolution Diffusion Imaging (msHARDI)-Based Tractography With Intra-operative Cortical Stimulation |
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| Completed | N/A | 68 | US | MRI, Neurocognitive battery | Abramson Cancer Center at Penn Medicine | Brain Lesions | 10/20 | 07/22 | | |
TRIDENT, NCT04471844: Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant with RT & TMZ for the Treatment of Newly Diagnosed GBM |
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| Active, not recruiting | N/A | 982 | Europe, Canada, Japan, US, RoW | Optune® | NovoCure Ltd. | Glioblastoma Multiforme | 01/26 | 01/26 | | |
| Brown, Gregory K |
NCT05307432: Safety Planning Intervention Telehealth Service Model in Emergency Departments |
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| Enrolling by invitation | N/A | 2814 | US | SPI+ Delivered by ED Staff, SPI+ Delivered by SPCC Clinicians | University of Pennsylvania, National Institute of Mental Health (NIMH) | Suicide, Suicidal Ideation | 07/26 | 07/26 | | |
| Derk, Chris |
BLISSc-ILD, NCT05878717: A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease |
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| Recruiting | 2/3 | 300 | Europe, Japan, US, RoW | Belimumab, BENLYSTA™, GSK1550188, LymphoStat-B™, BENLYSTATM, GSK1550188, LymphoStat-B™, Placebo | GlaxoSmithKline | Systemic Sclerosis Associated Interstitial Lung Disease, Scleroderma, Systemic | 07/27 | 07/27 | | |
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| Dixit, Sanjay |
| Recruiting | 2 | 234 | Europe | Nabiximols, Sativex, Temozolomide, Nabiximols-matched placebo | University of Birmingham, University of Leeds, The Brain Tumour Charity, Jazz Pharmaceuticals | Glioblastoma, Brain Tumor, Cannabis, Brain Tumor, Recurrent | 02/26 | 02/27 | | |
| Terminated | N/A | 8 | US | Ablation | University of Pennsylvania | Atrial Fibrillation | 02/23 | 02/23 | | |
| Reddy, K Rajender |
| Recruiting | 3 | 380 | Europe, US | SMT + PE-A 5%, Albutein 5%, Standard Medical Treatment, SMT | Grifols Therapeutics LLC, Instituto Grifols, S.A. | Acute-On-Chronic Liver Failure | 10/26 | 10/26 | | |
NCT05104853: Study to Evaluate the Safety, Tolerability, PDs, and Efficacy of CNP-104 in Subjects with Primary Biliary Cholangitis |
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| Active, not recruiting | 1/2 | 42 | US | CNP-104, Placebo | COUR Pharmaceutical Development Company, Inc. | Primary Biliary Cholangitis | 01/26 | 01/26 | | |
ALTUS, NCT05064553: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk |
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| Recruiting | N/A | 2500 | US | Study CT/MRI Imaging, Standard of Care CT/MRI Imaging, Oncoguard™ Liver Test | Exact Sciences Corporation | Hepatocellular Carcinoma, Hepatocellular Cancer, Hepatitis B, Cirrhosis, Liver Cancer | 01/25 | 04/26 | | |
| Bloom, Roy |
PTAAK, NCT03841097: Pulse Wave Velocity, Tacrolimus Time in Therapeutic Range and CV in African American Kidney Transplants |
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| Recruiting | 4 | 60 | US | Extended Release Tacrolimus Tablets, LCPT, Envarsus XR®, Immediate Release Tacrolimus Capsule, IR-TAC, Prograf® | Roy D. Bloom, MD, Veloxis Pharmaceuticals | Kidney Transplant; Complications | 03/25 | 09/25 | | |
| Recruiting | 2/3 | 180 | US | Anti-BK polyomavirus (AntiBKV) | Memo Therapeutics AG | BK Viremia; BKV DNAemia | 11/24 | 11/24 | | |
NCT05917522: Assessment of Biomarker-Guided CNI Substitution In Kidney Transplantation |
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| Recruiting | 2 | 800 | US | Abatacept, Orencia, Standard of Care at US Transplant Centers | National Institute of Allergy and Infectious Diseases (NIAID) | Kidney Transplant | 07/27 | 07/29 | | |
KOAR, NCT03326076: Evaluation of Patient Outcomes From the Kidney Allograft Outcomes AlloSure Registry |
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| Active, not recruiting | N/A | 4000 | US | Donor-derived cell-free DNA (AlloSure®), Standard care, Peripheral blood gene expression profiling (AlloMap Kidney), Analytic platform (IBox) | CareDx | Kidney Transplant Rejection | 06/25 | 12/25 | | |
| Bleier, Joshua |
| Active, not recruiting | N/A | 40 | US | Neuromodulation | Boomerang Medical | IBD | 12/24 | 12/24 | | |
NCT04940611: A Study of Surgical Interventions in Fistulizing Conditions |
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| Active, not recruiting | N/A | 750 | Europe, Canada, US, RoW | | Takeda | Crohns Disease, Fistula, Rectovaginal Fistula, Complex Perianal Fistula, Complex Cryptoglandular Fistula | 05/26 | 05/26 | | |
| Litt, Harold I |
| Completed | N/A | 872 | US | MRI | University of Pennsylvania | Pacemaker, Implantable Cardioverter Defibrillators | 12/19 | 02/22 | | |
NCT04267094: Reduced Radiation Dose and IR-impact on Coronary Calcium Quantification |
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| Terminated | N/A | 190 | US | Iterative reconstruction at reduced radiation dose | University of Pennsylvania | Atherosclerotic Plaque | 03/23 | 03/23 | | |
| Recruiting | N/A | 600 | Europe, US, RoW | Echocardiography, Magnetic resonance imaging (MRI), Computed tomography (CT) | Stanford University, The Cleveland Clinic, University of Pennsylvania, Erasmus Medical Center, Seoul National University Hospital | Non-Compaction Cardiomyopathy | 04/25 | 04/25 | | |
| Martin, Lainie P |
NRG-GY019, NCT04095364: Letrozole With or Without Paclitaxel and Carboplatin in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer |
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| Recruiting | 3 | 450 | Europe, Canada, US, RoW | Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Imaging Technique, Diagnostic Imaging Technique, Image Type, Imaging, Imaging (procedure), imaging procedure, Imaging Procedures, imaging type, IMAGING_METHOD, imaging_type, Medical Imaging, Type of imaging, Letrozole, CGS 20267, Femara, Fempro, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat | NRG Oncology, National Cancer Institute (NCI) | Low Grade Fallopian Tube Serous Adenocarcinoma, Ovarian Low Grade Serous Adenocarcinoma, Primary Peritoneal Low Grade Serous Adenocarcinoma, Stage II Fallopian Tube Cancer AJCC v8, Stage II Ovarian Cancer AJCC v8, Stage II Primary Peritoneal Cancer AJCC v8, Stage III Fallopian Tube Cancer AJCC v8, Stage III Ovarian Cancer AJCC v8, Stage III Primary Peritoneal Cancer AJCC v8, Stage IV Fallopian Tube Cancer AJCC v8, Stage IV Ovarian Cancer AJCC v8, Stage IV Primary Peritoneal Cancer AJCC v8 | 02/27 | 02/28 | | |
| Active, not recruiting | 1/2 | 523 | US | upifitamab rilsodotin, XMT-1536, UpRi | Mersana Therapeutics | Platinum Resistant Ovarian Cancer, Non Small Cell Lung Cancer Metastatic | 05/23 | 10/24 | | |
| Recruiting | 1/2 | 378 | Europe, US | DF1001, Nivolumab, Nab paclitaxel, Sacituzumab Govitecan-hziy | Dragonfly Therapeutics, Dragonfly Therapeutics, Inc. | Solid Tumor, Adult | 10/26 | 12/26 | | |
| Active, not recruiting | 1 | 86 | Europe, Canada, US | Pegylated Liposomal Doxorubicin + SL-172154, Doxil, PLD, Caelyx, Mirvetuximab + SL-172154, IMGN853, MIRV | Shattuck Labs, Inc. | Platinum-resistant Ovarian Cancer, Fallopian Tube Cancer, Epithelial Ovarian Cancer, Ovarian Cancer, Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Primary Peritoneal Carcinoma | 11/24 | 11/24 | | |
STRO-002-GM1, NCT03748186: Study of STRO-002, an Anti-Folate Receptor Alpha (FolRα) Antibody Drug Conjugate in Ovarian & Endometrial Cancers |
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| Completed | 1 | 136 | Europe, US | STRO-002 | Sutro Biopharma, Inc. | Ovarian Cancer, Ovarian Carcinoma, Ovary Cancer, Endometrial Cancer, Endometrioid Adenocarcinoma, Fallopian Tube Cancer, Primary Peritoneal Carcinoma | 06/24 | 06/24 | | |
| Kochman, Michael L |
| Completed | N/A | 700 | US | | University of Pennsylvania | Post-ERCP Acute Pancreatitis | 08/21 | 01/23 | | |
| Completed | N/A | 600 | US | Generic message, Tailored message | University of Pennsylvania | Colorectal Cancer | 06/23 | 10/23 | | |
| Goldberg, Lee |
| Active, not recruiting | 2 | 385 | US | tocilizumab, Actemra®, Placebo, Placebo for tocilizumab, Placebo for Actemra®, Standard of Care Triple IS, calcineurin inhibitor: (tacrolimus (Prograf ®)), anti-proliferative treatment: (mycophenolate mofetil ),, MMF, CellCept®, Myfortic®, enteric-coated mycophenolate sodium, steroids: methylprednisolone/prednisone | National Institute of Allergy and Infectious Diseases (NIAID), PPD | Heart Transplant | 04/25 | 04/25 | | |
| Not yet recruiting | N/A | 270 | NA | Synchronized Diaphragmatic Stimulation, Asymptomatic Diaphragmatic Stimulation, SDS, ADS, VisONE SDS | VisCardia Inc., Clinical Accelerator Ltd., Duke Clinical Research Institute | Heart Failure With Reduced Ejection Fraction | 07/27 | 12/27 | | |
| Enrolling by invitation | N/A | 30 | US | Cardiomems | University of Pennsylvania | Heart Failure, Congestive | 06/25 | 06/25 | | |
| Recruiting | N/A | 500 | Europe, US | remede System | Respicardia, Inc. | Central Sleep Apnea | 06/27 | 06/32 | | |
| Bella, Paolo Della |
MYOPED, NCT06591260: Role of Endomyocardial Biopsy and Aetiology-based Treatment in Pediatric Patients with Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management |
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| Recruiting | N/A | 20 | Europe | support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation | Scientific Institute San Raffaele | Myocarditis, Ventricular Arrhythmia, Inflammatory Cardiomyopathy, Genetic Predisposition, Autoimmunity, Arrhythmia, Cardiomyopathies, Immunosuppresion, Catheter Ablation | 12/25 | 12/30 | | |
AINICM, NCT06607471: Multimodal and Multidisciplinary Approach to Optimize Diagnostic, Prognostic, and Therapeutic Management of Patients with Non-ischemic Cardiomyopathies and Arrhythmogenic-inflammatory Phenotypes: a Multicenter, Observational, Retrospective and Prospective Registry Study. |
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| Recruiting | N/A | 15000 | Europe | Support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation, Support treatment, cardiac medical treatment, aetiology-specific treatment | Scientific Institute San Raffaele | Non-ischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM), Hypertrophic Cardiomyopathy (HCM), Restrictive Cardiomyopathy, Arrhythmogenic Cardiomyopathy (AC, ARVD/C), Left Ventricular Noncompaction, Arrhythmogenic Mitral Valve Prolapse, Peripartum Cardiomyopathy, Anderson-Fabry Disease, Arrhythmic and Inflammatory Non-ischemic Cardiomyopathy, Inflammatory (Non-Arrhythmic) Non-ischemic Cardiomyopathy, Nonischemic Cardiomyopathy Sensu Strictu (Non-inflammatory, Non-arrhythmic), Major Ventricular Arrhythmias, I.e. Sustained Ventricular Tachycardia, Ventricular Fibrillation, or Appropriate Therapy of Cardiac Device (defibrillators), Overlapping Phenotype, Undefined Phenotypes | 12/35 | 12/35 | | |
LESS-VT, NCT03490201: FLExAbility Sensor Enabled Substrate Targeted Ablation for the Reduction of VT Study |
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| Completed | N/A | 592 | Europe, US, RoW | Market Approved RF Ablation System, FlexAbility SE Ablation Catheter | Abbott Medical Devices | Ventricular Tachycardia | 04/24 | 04/24 | | |
NCT06371729: DEEP Substrate Mapping Versus Activation Mapping for VT |
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| Recruiting | N/A | 222 | Europe | DEEP mapping, Activation Mapping | IRCCS Ospedale San Raffaele | Ventricular Tachycardia | 06/27 | 06/27 | | |
| Recruiting | N/A | 3000 | Europe, Japan, RoW | Cardiac Resynchronization Therapy (CRT) | Biotronik SE & Co. KG | Heart Failure | 03/26 | 03/26 | | |
NCT06669299: Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies |
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| Not yet recruiting | N/A | 51 | Europe | Re-Do ventricular tachycardia ablation, Antiarrhythmic Drug Therapy (amiodarone, sotalol, or mexiletine) | IRCCS Ospedale San Raffaele | Ventricular Tachycardia (VT) | 12/27 | 12/27 | | |
IVTCC, NCT04520347: 2.0: a Prospective Multicenter Ventricular Tachycardia Catheter Ablation Registry |
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| Enrolling by invitation | N/A | 10000 | Europe, Canada, Japan, US, RoW | | University of California, Los Angeles | Ventricular Arrhythmia, Ventricular Tachycardia, Premature Ventricular Contraction (PVC), Cardiomyopathy | 12/26 | 11/27 | | |
MYOCAR, NCT04521790: Role of Endomyocardial Biopsy and Aetiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management |
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| Recruiting | N/A | 1000 | Europe | support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation | Scientific Institute San Raffaele | Myocarditis, Ventricular Arrythmia, Inflammatory Cardiomyopathy, Genetic Predisposition, Autoimmunity, Arrhythmia, Cardiomyopathies, Immunosuppression, Catheter Ablation | 12/25 | 12/35 | | |
| Bekelman, Justin |
| Active, not recruiting | N/A | 6000 | US | Framed Introductory Message A, Framed Introductory Message B, Framed Introductory Message C, Framed Tobacco Use Message A, Framed Tobacco Use Message B, Financial Incentive | Abramson Cancer Center at Penn Medicine, National Institutes of Health (NIH), National Cancer Institute (NCI) | Lung Cancer | 01/24 | 12/27 | | |
| Active, not recruiting | N/A | 454 | US | Proton Beam Therapy, Intensity Modulated Radiation Therapy | Massachusetts General Hospital, University of Pennsylvania, National Cancer Institute (NCI), Northwestern Medicine Chicago Proton Center, ProCure Proton Therapy Center, Washington University School of Medicine, University of Washington, Rutgers Cancer Institute of New Jersey, Provision Center for Proton Therapy, Mayo Clinic, University of Maryland Medical Center, University Hospitals Cleveland Medical Center, University of Florida Proton Therapy Institute | Prostate Cancer | 08/24 | 08/27 | | |
RADCOMP, NCT02603341: Pragmatic Randomized Trial of Proton Vs. Photon Therapy for Patients with Non-Metastatic Breast Cancer: a Radiotherapy Comparative Effectiveness () Consortium Trial |
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| Active, not recruiting | N/A | 1238 | US | Photon, Proton | Abramson Cancer Center at Penn Medicine, Patient-Centered Outcomes Research Institute | Breast Cancer | 08/28 | 11/36 | | |
TESTING, NCT05790460: Telehealth Based Synchronous Navigation to Improve Molecularly-Informed Care for Patients With Lung Cancer |
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| Terminated | N/A | 55 | US | Telehealth | Abramson Cancer Center at Penn Medicine, National Cancer Institute (NCI) | Non-small Cell Lung Cancer | 01/24 | 04/24 | | |
| Margulies, Kenneth |
NCT02123706: A Phase IIa, Single-blind, Placebo-controlled, Crossover, Multi-center, Randomized Study to Assess the Safety, Tolerability, and Preliminary Efficacy of a Single Intravenous Dose of Ischemia-tolerant Allogeneic Mesenchymal Bone Marrow Cells to Subjects With Heart Failure of Non-ischemic Etiology |
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| Recruiting | 2a | 20 | US | Human Allogeneic Mesenchymal Stem Cells, Mesenchymal Stem Cells, Marrow Stromal Cells, Placebo, Lactated Ringer's Solution | Stemedica Cell Technologies, Inc., CardioCell, LLC; A Stemedica Company | Non-ischemic Heart Failure | 06/16 | 06/16 | | |
NCT04956809: Effect of Dapagliflozin on Submaximal Exercise Tolerance in Heart Failure |
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| Completed | 2 | 3 | US | Dapagliflozin 10Mg Tab, Placebo | University of Pennsylvania, Amgen | HFrEF | 06/23 | 06/23 | | |
| Enrolling by invitation | N/A | 40 | US | | University of Pennsylvania, Amgen | Heart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure | 06/25 | 08/25 | | |
| Patel, Mitesh |
BE ACTIVE, NCT03911141: Behavioral Economic Approaches to Increase Physical Activity Among Patients With Elevated Risk for Cardiovascular Disease |
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| Completed | N/A | 1062 | US | Gamification, Financial | University of Pennsylvania | Atherosclerotic Cardiovascular Disease | 07/23 | 01/24 | | |
NCT05799976: Text Message-Based Nudges Prior to Primary Care Visits to Increase Care Gap Closure |
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| Completed | N/A | 29334 | US | Text message nudge | Mitesh Patel | Pneumonia, Pneumococcal, Diabetes Mellitus, Breast Cancer, Colorectal Cancer | 11/23 | 02/24 | | |
NCT04536038: Framing Clinical Trial Enrollment for Patients With Peripheral Artery Disease |
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| Active, not recruiting | N/A | 1200 | US | Opt-out | University of Pennsylvania | Peripheral Artery Disease | 07/23 | 02/25 | | |
| Completed | N/A | 103 | US | Gamification and Social Incentives | University of Pennsylvania | Peripheral Artery Disease | 11/23 | 01/24 | | |
| Mehta, Shivan |
NCT05160012: Peer Comparison Feedback to Providers to Improve Hypertension Control |
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| Active, not recruiting | N/A | 93 | US | Peer Comparison Message | University of Pennsylvania | Hypertension | 10/22 | 01/25 | | |
| Completed | N/A | 150 | US | Control, Text-based Clinical Hovering | University of Pennsylvania | Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis | 01/23 | 01/23 | | |
NCT05724615: Default Bulk Ordering and Text Messaging to Enhance Outreach for Lipid Screening (Missing Lipids) |
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| Completed | N/A | 1000 | US | Outreach + Bulk ordering, Outreach + Bulk ordering + Text Based Reminders and Scheduling assistance | University of Pennsylvania | Atherosclerotic Cardiovascular Disease | 09/23 | 12/23 | | |
| Completed | N/A | 80063 | US | Pre-visit patient text messaging, Default pended order, Monthly peer comparison feedback, High risk bidirectional pre-visit text messaging | University of Pennsylvania, National Institute on Aging (NIA), University of Washington | Behavior, Health, Flu, Flu Vaccination | 02/24 | 05/24 | | |
NCT06136221: Testing LiverWatch, a Home-Based Remote-Monitoring Intervention for Advanced Liver Disease |
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| Recruiting | N/A | 110 | US | LiverWatch Intervention | University of Pennsylvania, Pennsylvania Department of Health | Cirrhosis, Liver, End Stage Liver DIsease, Symptoms and Signs, Physical Inactivity, Muscle Loss | 05/25 | 05/26 | | |
TESTING, NCT05790460: Telehealth Based Synchronous Navigation to Improve Molecularly-Informed Care for Patients With Lung Cancer |
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| Terminated | N/A | 55 | US | Telehealth | Abramson Cancer Center at Penn Medicine, National Cancer Institute (NCI) | Non-small Cell Lung Cancer | 01/24 | 04/24 | | |
| Enrolling by invitation | N/A | 65855 | US | Pre-visit patient text messaging, Default pended order, Monthly peer comparison feedback, High risk bidirectional pre-visit text messaging | University of Pennsylvania, National Institute on Aging (NIA) | Behavior, Health, Flu, Flu Vaccination | 02/25 | 05/25 | | |
TEST, NCT05260268: Technology Enabled Strategies to Promote Treatment Adherence in Liver Transplant |
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| Recruiting | N/A | 360 | US | TEST Intervention | University of Pennsylvania, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Liver Transplant; Complications, Cirrhosis, End Stage Liver DIsease, Medication Adherence | 07/26 | 01/27 | | |
NCT05693649: Behavioral Economic Approaches for Population-Based Colorectal Cancer Screening |
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| Active, not recruiting | N/A | 20000 | US | No Direct Patient Outreach, Direct Patient Outreach: Colonoscopy Only, Direct Patient Outreach: Sequential Choice, Visit-Based Nudge/Text, No Nudge/Text | Abramson Cancer Center at Penn Medicine | Colorectal Cancer | 12/26 | 12/26 | | |
| Epstein, Jonathan |
| Recruiting | N/A | 6000 | Europe | Observational registry | Central Hospital, Nancy, France, Institut National de la Santé Et de la Recherche Médicale, France, University of Lorraine | Multiple Sclerosis | 01/30 | 01/30 | | |
| Lin, Alexander |
NCT01893307: Intensity-Modulated Proton Beam Therapy or Intensity-Modulated Photon Therapy in Treating Patients with Stage III-IVB Oropharyngeal Cancer |
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| Active, not recruiting | 2/3 | 440 | US | Intensity-Modulated Radiation Therapy, IMRT, Intensity Modulated RT, Intensity-Modulated Radiotherapy, Radiation, Intensity-Modulated Radiotherapy, Laboratory Biomarker Analysis, Photon Beam Radiation Therapy, Photon EBRT, Photon External Beam Radiotherapy, Radiation, Photon Beam, Proton Beam Radiation Therapy, PBRT, Proton, Proton EBRT, Proton External Beam Radiotherapy, Proton Radiation Therapy, Radiation, Proton Beam, Quality-of-Life Assessment, Quality of Life Assessment | M.D. Anderson Cancer Center, National Cancer Institute (NCI), National Institute of Dental and Craniofacial Research (NIDCR) | Stage III Oropharyngeal Squamous Cell Carcinoma AJCC V7, Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC V7, Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC V7 | 08/25 | 08/25 | | |
NCT02207439: Phase II Trial of Nelfinavir With Concurrent Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck |
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| Completed | 2 | 18 | US | Nelfinavir (Viracept®) 1250 mg, Nelfinavir Lead-In, Chemoradiation | Abramson Cancer Center at Penn Medicine | Head and Neck Squamous Cell Carcinoma | 05/21 | 05/22 | | |
NCT05714657: Shortened Course Adjuvant Radiotherapy Following TORS |
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| Recruiting | 2 | 104 | US | Shortened Course Adjuvant Radiotherapy Following TORS | Abramson Cancer Center at Penn Medicine | HPV-Associated Oropharyngeal Squamous Cell Carcinoma | 12/25 | 04/26 | | |
RADCOMP, NCT02603341: Pragmatic Randomized Trial of Proton Vs. Photon Therapy for Patients with Non-Metastatic Breast Cancer: a Radiotherapy Comparative Effectiveness () Consortium Trial |
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| Active, not recruiting | N/A | 1238 | US | Photon, Proton | Abramson Cancer Center at Penn Medicine, Patient-Centered Outcomes Research Institute | Breast Cancer | 08/28 | 11/36 | | |
NCT05309356: Using Clinical Prediction Models to Improve Treatment for Patients With Chronic Obstructive Pulmonary Disease (COPD) |
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| Recruiting | N/A | 1130 | Canada | ACCEPT Decision Intervention, Comparator | University of British Columbia, Providence Health & Services, Vancouver Coastal Health | Chronic Obstructive Pulmonary Disease | 01/25 | 07/25 | | |
| Beatty, Gregory |
| Active, not recruiting | 3 | 825 | US | Gemcitabine combined with nab-paclitaxel, Dose -mFOLFIRINOX, Dose - Pamrevlumab combined with gemcitabine and nab-paclitaxel, Dose- Canakinumab and Spartalizumab combined with nab-paclitaxel and gemcitabine, Drug: Dose -SM-88 | Pancreatic Cancer Action Network | Metastatic Pancreatic Cancer, Metastatic Pancreatic Adenocarcinoma | 06/27 | 06/27 | | |
| Lane-Fall, Meghan B |
| Completed | 3 | 300 | US | Anesthetic technique Propofol TIVA, Propofol TIVA, Anesthetic technique inhaled agent, Inhaled agent | Washington University School of Medicine, University of Michigan, University of Pennsylvania, Stanford University, Patient-Centered Outcomes Research Institute | Surgery--Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia Emergence Delirium, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Nausea, Postoperative, Anesthesia Morbidity, Depression, Sleep Disorders, Circadian Rhythm | 04/23 | 06/23 | | |
| Enrolling by invitation | N/A | 4000 | US | Customized handoff | University of Pennsylvania, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) | Patient Handoff, Healthcare Team, Communication, Patient Safety, Intensive Care Units | 06/25 | 07/25 | | |
| Desai, Nimesh |
| Recruiting | N/A | 110 | US, RoW | NEXUS Aortic Stent Graft System | Endospan Ltd. | Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer | 11/24 | 10/29 | | |
TAMBE, NCT05442489: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of the Thoracoabdominal and Pararenal Aortic Aneurysms |
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| Approved for marketing | N/A | | US | GORE Excluder Thoracoabdominal Branch Endoprosthesis, TAMBE | W.L.Gore & Associates | Thoracoabdominal Aneurysm | | | | |
SSB 11-02, NCT02777528: Evaluation of the GORE® TAG® Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta (Zone 0/1) |
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| Active, not recruiting | N/A | 150 | Japan, US | GORE® TAG® Thoracic Branch Endoprosthesis, Revascularization Procedure | W.L.Gore & Associates | Aortic Aneurysm, Thoracic, Aorta, Lesion | 03/24 | 03/28 | | |
| Recruiting | N/A | 282 | Canada, US | Hypothermic circulatory arrest | Ottawa Heart Institute Research Corporation | Thoracic Aortic Disease | 02/25 | 09/25 | | |
| Recruiting | N/A | 610 | Canada, US | Thoracic Aortic Surgery | Ottawa Heart Institute Research Corporation, University of Calgary | Ascending Aortic Aneurysm Enlargement, Ascending Aorta Aneurysm | 05/25 | 05/26 | | |
| Recruiting | N/A | 2000 | Europe, Canada, US | Gelsoft Plus Vascular Graft, Gelsoft Plus, Vascular Bypass Graft, Gelsoft Plus Extra Anatomical, Cardiovascular Patch, Gelseal Patch, Gelsoft Patch, Thinwall Patch, Cardiovascular Fabrics, Gelweave Vascular Graft, Gelweave, Gelweave Valsalva Vascular Graft, Gelweave Valsalva | Vascutek Ltd. | Aneurysm, Dissection, Aortic Root Aneurysm, Aortic Root Dissection, Carotid Artery Injuries, Aortic Arch, Bypass Extremity Graft, Occlusive Vascular Disease, Aortic Diseases | 01/26 | 01/33 | | |
TAMBE, NCT03728985: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms |
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| Active, not recruiting | N/A | 102 | Europe, US | GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis, TAMBE | W.L.Gore & Associates | Thoracoabdominal Aortic Aneurysm | 01/23 | 09/26 | | |
| Messe, Steven |
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction |
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| Terminated | 3 | 535 | Europe, Canada, Japan, US, RoW | BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo | Remedy Pharmaceuticals, Inc. | Brain Edema, Stroke, Acute | 08/23 | 08/23 | | |
| Recruiting | 2/3 | 728 | US | Recombinant human tissue kallikrein, DM199, Placebo for DM199 Solution for Injection | DiaMedica Therapeutics Inc | Acute Stroke, Ischemic Stroke, Stroke | 12/26 | 12/26 | | |
| Withdrawn | 2 | 40 | US | OsciPulse system, Flowtron ACS900 | OsciFlex LLC, University of Pennsylvania | Venous Thromboses, Ischemic Stroke | 12/22 | 03/23 | | |
| Active, not recruiting | 2 | 40 | US | Nitric Oxide, iNO, NO2 | Steven Messe, Mallinckrodt | Stroke | 07/25 | 07/25 | | |
| Not yet recruiting | N/A | 40 | US | OsciPulse, Intermittent Pneumatic Compression | University of Pennsylvania, OsciFlex LLC | Ischemic Stroke | 11/25 | 11/25 | | |
CHaMP, NCT05155956: Cerebral Hemodynamics and Microemboli During Placement of Relay®Branch Thoracic Stent-Graft System |
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| Active, not recruiting | N/A | 20 | US | transcranial Doppler ultrasonography (TCD) | University of Pennsylvania, Bolton Medical | Thoracic Aortic Aneurysm, Thoracic Aortic Dissection, Microemboli | 12/24 | 12/25 | | |
| Recruiting | N/A | 3062 | US | CPAP | University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), FusionHealth LLC, Medical University of South Carolina, University of Cincinnati | Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial | 11/26 | 11/26 | | |
| Zamani, Payman |
| Recruiting | 2 | 53 | US | Potassium Nitrate, KNO3, Potassium Nitrate + Propionyl-L-Carnitine + Nicotinamide Riboside, KNO3 + PLC + NR, Potassium Chloride, PCl | University of Pennsylvania | Heart Failure With Preserved Ejection Fraction | 01/26 | 01/26 | | |
| Recruiting | 2 | 53 | US | Empagliflozin + Potassium Chloride, Jardiance + KCl, Empagliflozin + Potassium Nitrate, Jardiance + KNO3, Potassium Chloride + Placebo for Empagliflozin, KCl + Placebo | University of Pennsylvania | Heart Failure With Preserved Ejection Fraction | 03/26 | 03/26 | | |
| Cuker, Adam |
| Withdrawn | 3 | 85 | US | SPK-8011, AAV-Spark200-BDD-hFVIII, Dirloctocogene samoparvovec | Spark Therapeutics, Inc. | Hemophilia A | 05/27 | 09/35 | | |
VAYHIT2, NCT05653219: A Study of Efficacy and Safety of Ianalumab Versus Placebo in Addition to Eltrombopag in Primary Immune Thrombocytopenia Patients Who Failed Steroids |
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| Recruiting | 3 | 150 | Europe, Japan, US, RoW | Ianalumab, VAY736, Eltrombopag, ETB115, Placebo | Novartis Pharmaceuticals | Primary Immune Thrombocytopenia | 08/25 | 05/28 | | |
VAYHIT1, NCT05653349: Study of Ianalumab Versus Placebo in Addition to First-line Corticosteroids in Primary Immune Thrombocytopenia (ITP) |
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| Recruiting | 3 | 225 | Europe, Japan, US, RoW | Ianalumab, VAY736, Placebo, Corticosteroids | Novartis Pharmaceuticals | Primary Immune Thrombocytopenia (ITP) | 04/26 | 12/28 | | |
| Recruiting | 2 | 51 | US | emicizumab, Hemlibra (R) | University of Washington, Genentech, Inc. | Acquired Hemophilia A | 07/25 | 12/25 | | |
VAYHIT3, NCT05885555: A Study of Ianalumab (VAY736) in Patients With Primary Immune Thrombocytopenia (ITP) Previously Treated With at Least Two Lines of Therapies |
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| Active, not recruiting | 2 | 41 | Europe, US, RoW | Ianalumab, VAY736 | Novartis Pharmaceuticals | Primary Immune Thrombocytopenia (ITP) | 02/25 | 03/29 | | |
| Active, not recruiting | N/A | 108 | US | | American Thrombosis and Hemostasis Network, Takeda | Von Willebrand Diseases | 12/24 | 01/25 | | |
NCT05904210: Retrospective Experience Assessing the Real-World Utilization and Effectiveness of SEVENFACT® |
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| Completed | N/A | 17 | US | SEVENFACT® | Laboratoire français de Fractionnement et de Biotechnologies | Hemophilia | 05/24 | 05/24 | | |
| Recruiting | N/A | 3000 | US | | American Thrombosis and Hemostasis Network, Pfizer, Hemophilia of Georgia, Inc., Genentech, Inc., Hemab Therapeutics, CSL Behring, Sanofi, Novo Nordisk A/S | Hematologic Disorder, Bleeding Disorder, Connective Tissue Disorder, Hemophilia, Thrombosis, Von Willebrand Diseases, Thrombophilia, Rare Bleeding Disorder, Platelet Disorder, Factor IX Deficiency, Factor VIII Deficiency, Thalassemia, Sickle Cell Disease | 06/35 | 12/35 | | |
| Apter, Andrea J |
HAP3, NCT04023422: Clinic Navigation and Home Visits to Improve Guideline-based Care and Outcomes in Low Income Minority Adults With Asthma |
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| Active, not recruiting | N/A | 367 | US | Clinical intervention, Home Visit, Feedback | University of Pennsylvania, National Heart, Lung, and Blood Institute (NHLBI) | Asthma | 04/25 | 04/25 | | |
| Lautenbach, Ebbing |
| Completed | N/A | 585 | US | Copper linen exposure | University of Pennsylvania, Centers for Disease Control and Prevention | Critically Ill | 08/16 | 12/23 | | |
NCT02207114: Using Biomarkers to Optimize Antibiotic Strategies in Sepsis |
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| Completed | N/A | 145 | US | Biomarker Algorithm Intervention | University of Pennsylvania | Sepsis | 12/16 | 12/23 | | |
NCT05734391: Surveillance of Healthcare-associated Infections & Antimicrobial Resistance |
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| Enrolling by invitation | N/A | 1500 | US, RoW | Routine Infection control, Surveillance activity | University of Pennsylvania | Antimicrobial Resistance | 12/27 | 12/27 | | |
EMPOWER, NCT06027593: Using Electronically Derived Automated Reports of Appropriate Antibiotic Use to Inform Stewardship Interventions |
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| Completed | N/A | 26139 | US | Mixed methods intervention, Quasi experimental intervention | Children's Hospital of Philadelphia, University of Pennsylvania, Centers for Disease Control and Prevention | Community-acquired Pneumonia, Acute Otitis Media, Pharyngitis | 06/24 | 07/24 | | |
CHARM, NCT06590675: Development and Evaluation of a ChlorHexidine Gluconate bAthing pRotocol for Healthcare Settings in Low- and Middle-income Countries |
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| Not yet recruiting | N/A | 270 | RoW | Chlorhexidine Gluconate (CHG), Aqueous CHG | University of Pennsylvania, Children's Hospital of Philadelphia, University of Botswana, Centers for Disease Control and Prevention, University of Utah, Imperial College London, Botswana-UPenn Partnership | Multidrug Resistant Bacterial Infection | 01/26 | 01/26 | | |
| Halpern, Casey |
NCT04620551: Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease |
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| Active, not recruiting | N/A | 20 | US | Sub-clinical stimulation | University of Nebraska, Stanford University, University of Colorado, Denver, University of Pennsylvania | Parkinson Disease, Sleep Fragmentation | 06/25 | 06/25 | | |
| Recruiting | N/A | 100 | US | Sham-stimulation, Active-stimulation | Abbott Medical Devices | Treatment Resistant Depression | 04/27 | 04/29 | | |
| Recruiting | N/A | 6 | US | responsive neurostimulation | University of Pennsylvania, NeuroPace | Loss of Control Eating, Obesity, Morbid | 01/25 | 01/25 | | |
