Wortmann, Glenn |
| Recruiting | 3 | 526 | Europe, US, RoW | Reparixin, Repertaxin L-lysine salt, Placebo, Matched placebo | Dompé Farmaceutici S.p.A | Infectious Pneumonia, Severe COVID-19 | 09/24 | 10/24 | | |
| Active, not recruiting | 2/3 | 125 | Canada, US | LAU-7b, fenretinide, Placebo oral capsule | Laurent Pharmaceuticals Inc. | COVID-19 Disease | 02/24 | 05/24 | | |
| Recruiting | 2b | 126 | US | Phage Therapy, Placebo | Adaptive Phage Therapeutics, Inc., United States Department of Defense | Osteomyelitis, Diabetic Foot Osteomyelitis | 04/24 | 12/24 | | |
Thourani, Vinod |
NCT02732691: JENAVALVE AS EFS TRIAL: Pericardial TAVR Aortic Stenosis Study |
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| Active, not recruiting | N/A | 68 | Europe, US, RoW | JenaValve Pericardial TAVR System | JenaValve Technology, Inc. | Aortic Valve Stenosis, Heart Valve Diseases, Heart Diseases, Cardiovascular Diseases, Ventricular Outflow Obstruction | 05/19 | 04/24 | | |
| Terminated | N/A | 12 | US | Edwards Cardioband System, Transcatheter mitral valve repair (TMVr), Guideline Directed Medical Therapy | Edwards Lifesciences | Functional Mitral Regurgitation, Mitral Regurgitation, Mitral Insufficiency | 07/19 | 09/22 | | |
NCT03539458: Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification |
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| Active, not recruiting | N/A | 11 | US | Tendyne Mitral Valve System | Abbott Medical Devices | Mitral Regurgitation, Mitral Insufficiency, Mitral Annular Calcification, Mitral Annulus Calcification, Cardiovascular Diseases, Valve Heart Disease, Heart Valve Diseases, Heart Valve Calcification, Mitral Valve Disease | 11/19 | 10/24 | | |
NCT02732704: THE ALIGN-AR EFS TRIAL: JenaValve Pericardial TAVR Aortic Regurgitation Study |
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| Active, not recruiting | N/A | 100 | Europe, US | JenaValve Pericardial TAVR System | JenaValve Technology, Inc. | Aortic Regurgitation | 08/22 | 09/27 | | |
| Active, not recruiting | N/A | 180 | US | JenaValve Trilogy Heart Valve System | JenaValve Technology, Inc. | Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency, Aortic Valve Disease | 08/23 | 08/28 | | |
| Active, not recruiting | N/A | 25 | Canada, US | HARPOON™ Beating Heart Mitral Valve Repair System | Edwards Lifesciences | Mitral Regurgitation | 10/23 | 12/27 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 15 | US | Transcatheter Tricuspid Valve Replacement | Trisol Medical | Tricuspid Regurgitation | 01/25 | 07/27 | | |
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation |
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| Recruiting | N/A | 958 | Canada, US | Tendyne Mitral Valve System, MitraClip System | Abbott Medical Devices | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease | 06/24 | 06/28 | | |
| Recruiting | N/A | 30 | Canada, US | Cephea Mitral Valve System | Abbott Medical Devices | Mitral Regurgitation | 06/24 | 06/29 | | |
| Recruiting | N/A | 1070 | Europe, US | Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy | Edwards Lifesciences | Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure | 06/24 | 12/29 | | |
NCT05913908: EFS of the DUO System for Tricuspid Regurgitation (TANDEM II) |
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| Recruiting | N/A | 15 | US | DUO Transcatheter Tricuspid Coaptation Valve System, DUO System | CroiValve Limited | Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases | 04/25 | 10/29 | | |
| Recruiting | N/A | 870 | Canada, US | Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy | Edwards Lifesciences | Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease | 12/24 | 03/29 | | |
NCT03382457: Clinical Study of Edwards Cardioband Tricuspid Valve Reconstruction System |
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| Active, not recruiting | N/A | 55 | US | Transcatheter Tricuspid Valve Reconstruction, Edwards Cardioband Tricuspid Valve Reconstruction | Edwards Lifesciences | Tricuspid Regurgitation | 01/25 | 01/30 | | |
| Recruiting | N/A | 500 | Europe, Canada, US | MitraClip™ device implantation, Mitral Valve Repair Surgery | Abbott Medical Devices | Mitral Valve Regurgitation | 04/26 | 04/34 | | |
| Active, not recruiting | N/A | 500 | Canada, US | MITRIS RESILIA Mitral Valve, Model 11400M | Edwards Lifesciences | Mitral Stenosis, Mitral Valve Insufficiency | 01/28 | 12/35 | | |
| Recruiting | N/A | 6500 | Europe, Canada, US | AtriClip LAA Exclusion System | AtriCure, Inc., Population Health Research Institute | Ischemic Stroke, Systemic Embolism | 12/31 | 04/32 | | |
Shupp, Jeffrey |
NCT05156983: A Study of TAK-330 for Reversal of Direct Oral Factor Xa Inhibitor-induced Anticoagulation |
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| Recruiting | 3 | 328 | Europe, Canada, US | TAK-330, SOC 4F-PCC | Takeda, Takeda Development Center Americas, Inc. | Coagulation Disorder | 11/25 | 11/25 | | |
NCT04040660: Use of NexoBrid for Treatment of Acute Deep Partial and Full Thickness Burn Injuries |
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| Available | N/A | | US | NexoBrid | MediWound Ltd | Thermal Burn | | | | |
NCT05023135: DeepView SnapShot Portable (DV-SSP): Device Training Study |
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| Completed | N/A | 251 | US | DeepView SnapShot Portable (DV-SSP) | SpectralMD | Burns, Wound Heal | 04/23 | 04/23 | | |
Bernardo, Nelson |
| Recruiting | N/A | 376 | Europe, US, RoW | SELUTION SLR™ DEB 014, Plain (Uncoated) Balloon Angioplasty (PTA) | MedAlliance, LLC, NAMSA | Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia Nos of Native Arteries of Extremities | 11/24 | 07/28 | | |
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN |
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| Recruiting | N/A | 1400 | Europe, US, RoW | Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation | Medtronic Vascular | Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus | 11/26 | 11/29 | | |
| Recruiting | N/A | 300 | Europe, US, RoW | SELUTION SLR™ 018 DEB, Plain (Uncoated) Balloon Angioplasty (PTA) | MedAlliance, LLC, NAMSA | Peripheral Arterial Disease, Superficial Femoral Artery Stenosis | 12/24 | 12/29 | | |
NCT04543539: IN.PACT™ AV Access Post-Approval Study (PAS002) |
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| Recruiting | N/A | 240 | US | IN.PACT™ AV Drug Coated Balloon (DCB) - Primary Cohort, IN.PACT™ AV Drug Coated Balloon (DCB) - Extended Cohort | Medtronic | Arteriovenous Fistula, Arteriovenous Fistula Stenosis, Arteriovenous Fistula Occlusion, Fistula | 02/25 | 02/29 | | |
Patchen, Loral |
KULEA-NET, NCT05985876: A Mobile Application for African American/Black Mothers to Promote Exclusive and Continuous Breastfeeding |
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| Enrolling by invitation | 2 | 523 | US | KULEA-NET application, Control Group: Usual Care | Benten Technologies, Inc., George Washington University, Medstar Health Research Institute, National Institute on Minority Health and Health Disparities (NIMHD) | Breastfeeding, Exclusive Breastfeeding | 04/24 | 05/24 | | |
Goyal, Munish |
| Recruiting | 3 | 200 | Europe, Canada, US, RoW | Bentracimab (PB2452) Infusion | SFJ Pharmaceuticals, Inc. | Hemorrhage, Urgent Surgery, Invasive Procedure | 08/24 | 08/24 | | |
Ailani, Jessica |
| Recruiting | N/A | 175 | Europe, US | Partial Rebreathing Device, Sham breathing device | Rehaler, Qmed Consulting A/S | Migraine With Aura | 10/24 | 10/25 | | |
Franchi, Francesco |
| Active, not recruiting | 4 | 105 | US | Ticagrelor monotherapy, Brilinta, Ticagrelor plus aspirin, Clopidogrel with aspirin, Plavix | University of Florida, AstraZeneca | Diabetes Mellitus, Type 2, Coronary Artery Disease | 01/24 | 08/24 | | |
| Recruiting | 3 | 200 | Europe, Canada, US, RoW | Bentracimab (PB2452) Infusion | SFJ Pharmaceuticals, Inc. | Hemorrhage, Urgent Surgery, Invasive Procedure | 08/24 | 08/24 | | |
VICTORION-2P, NCT05030428: Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease |
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| Active, not recruiting | 3 | 17006 | Europe, Canada, Japan, US, RoW | Inclisiran sodium 300 mg, Placebo | Novartis Pharmaceuticals | Atherosclerotic Cardiovascular Disease | 10/27 | 10/27 | | |
| Recruiting | 3 | 14000 | Europe, Canada, US, RoW | Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL, KJX839, Placebo in 1.5ml | Novartis Pharmaceuticals | Primary Prevention of Atherosclerotic Cardiovascular Disease | 04/29 | 04/29 | | |
Ohanian, Arbi G |
| Recruiting | N/A | 175 | Europe, US | Partial Rebreathing Device, Sham breathing device | Rehaler, Qmed Consulting A/S | Migraine With Aura | 10/24 | 10/25 | | |
Pokharel, Shreejana |
| Active, not recruiting | 3 | 125 | Canada, US | Autologous cell therapy, Sham | BioCardia, Inc. | Heart Failure, Systolic | 12/24 | 12/26 | | |
Fatima, Javairiah |
| Recruiting | N/A | 110 | US, RoW | NEXUS Aortic Stent Graft System | Endospan Ltd. | Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer | 08/24 | 10/29 | | |
TAMBE, NCT05442489: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of the Thoracoabdominal and Pararenal Aortic Aneurysms |
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| Available | N/A | | US | GORE Excluder Thoracoabdominal Branch Endoprosthesis, TAMBE | W.L.Gore & Associates | Thoracoabdominal Aneurysm | | | | |
SSB 11-02, NCT02777528: Evaluation of the GORE® TAG® Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta (Zone 0/1) |
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| Active, not recruiting | N/A | 150 | Japan, US | GORE® TAG® Thoracic Branch Endoprosthesis, Revascularization Procedure | W.L.Gore & Associates | Aortic Aneurysm, Thoracic, Aorta, Lesion | 03/24 | 03/28 | | |
| Recruiting | N/A | 102 | US | Zenith Fenestrated+ Endovascular Graft in combination with the BeGraft Balloon-Expandable FEVAR Bridging Stent Graft System and Unibody2 | Cook Research Incorporated | Aortic Aneurysm, Abdominal, Juxtarenal Aortic Aneurysm, Extent IV Thoracoabdominal, Pararenal Aneurysm | 06/26 | 04/31 | | |
TAMBE, NCT03728985: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms |
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| Recruiting | N/A | 122 | Europe, US | GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis, TAMBE | W.L.Gore & Associates | Thoracoabdominal Aortic Aneurysm | 06/26 | 09/26 | | |
| Recruiting | N/A | 300 | US | TREO Abdominal Stent-Graft System | Bolton Medical | Abdominal Aortic Aneurysm | 07/27 | 07/27 | | |
Singh, Suman |
| Recruiting | 2/3 | 400 | US | Nectero EAST System | Nectero Medical, Inc. | Abdominal Aortic Aneurysm | 03/27 | 12/29 | | |
| Recruiting | N/A | 110 | US, RoW | NEXUS Aortic Stent Graft System | Endospan Ltd. | Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer | 08/24 | 10/29 | | |
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN |
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| Recruiting | N/A | 1400 | Europe, US, RoW | Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation | Medtronic Vascular | Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus | 11/26 | 11/29 | | |
| Not yet recruiting | N/A | 125 | US | Cleaner Pro Thrombectomy System, Cleaner Vac Thrombectomy System | Argon Medical Devices, NAMSA | Pulmonary Embolism, Acute Pulmonary Embolism, Cardiovascular Diseases, Venous Thromboembolism | 07/25 | 08/25 | | |
| Recruiting | N/A | 111 | Europe, US, RoW | GORE® VIAFORT Vascular Stent | W.L.Gore & Associates | Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease | 01/25 | 01/29 | | |
NCT05489588: The GORE® VIAFORT Vascular Stent Iliofemoral Study |
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| Recruiting | N/A | 165 | US | GORE® VIAFORT Vascular Stent | W.L.Gore & Associates | Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease | 04/25 | 04/29 | | |
Bethea, Brian |
| Active, not recruiting | N/A | 572 | Europe, Canada, US | TriClipTM Device | Abbott Medical Devices | Tricuspid Regurgitation | 11/22 | 04/29 | | |
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation |
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| Recruiting | N/A | 958 | Canada, US | Tendyne Mitral Valve System, MitraClip System | Abbott Medical Devices | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease | 06/24 | 06/28 | | |
Shults, Christian |
| Recruiting | N/A | 585 | US | NeoChord DS1000, Surgical Mitral Valve Repair | NeoChord | Mitral Valve Insufficiency | 07/22 | 07/27 | | |
| Recruiting | N/A | 110 | US, RoW | NEXUS Aortic Stent Graft System | Endospan Ltd. | Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer | 08/24 | 10/29 | | |
| Completed | N/A | 140 | Canada, US | DrugSorb-ATR system, Sorbent hemoperfusion system, Sham comparator | CytoSorbents, Inc | Hemorrhage, Surgical, Blood Loss, Surgical, Blood Loss, Postoperative, Hemorrhage Postoperative | 08/23 | 08/23 | | |
NCT03033043: Study of the RelayPro Thoracic Stent-Graft in Subjects With an Acute, Complicated Type B Aortic Dissection |
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| Active, not recruiting | N/A | 56 | US | Relay Pro Stent-Graft, Relay Pro Stent Graft System | Bolton Medical | Aortic Dissection Type B | 10/21 | 10/26 | | |
| Recruiting | N/A | 15 | US | AltaValve | 4C Medical Technologies, Inc. | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence | 09/25 | 09/25 | | |
| Recruiting | N/A | 142 | Europe, US | AtriCure ISOLATOR Synergy Surgical Ablation System | AtriCure, Inc. | Inappropriate Sinus Tachycardia | 06/26 | 06/27 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Recruiting | N/A | 200 | Europe, US | Thoraflex Hybrid, RelayPro NBS | Vascutek Ltd., Bolton Medical | Thoracic Diseases, Aortic Aneurysm, Aortic Dissection, Thoracic Aortic Aneurysm, Thoracic Aortic Dissection | 12/35 | 12/36 | | |
Olano, Arrel |
NCT05176899: Real-World Evaluation of Eko Murmur Analysis Software in a Point of Care Setting |
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| Recruiting | N/A | 1200 | US | Use of Eko CORE electronic stethoscope | Eko Devices, Inc. | Murmur, Heart, Innocent Murmurs, Heart Murmurs, Pathologic Murmur | 11/23 | 11/23 | | |
Kanth, Priyanka |
NCT05625529: ExoLuminate Study for Early Detection of Pancreatic Cancer |
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| Recruiting | N/A | 1000 | US | | Biological Dynamics, Medical College of Wisconsin, Dana-Farber Cancer Institute | Pancreas Cancer, Exosomes, Extracellular Vesicles, Pancreatic Neoplasms | 01/26 | 01/27 | | |
Moyer, Keith |
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation |
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| Recruiting | N/A | 958 | Canada, US | Tendyne Mitral Valve System, MitraClip System | Abbott Medical Devices | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease | 06/24 | 06/28 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
Khurana, Neal |
| Not yet recruiting | N/A | 125 | US | Cleaner Pro Thrombectomy System, Cleaner Vac Thrombectomy System | Argon Medical Devices, NAMSA | Pulmonary Embolism, Acute Pulmonary Embolism, Cardiovascular Diseases, Venous Thromboembolism | 07/25 | 08/25 | | |
Collins, Erin |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 25 | US | J-Valve TF System | JC Medical, Inc. | Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Regurgitation | 03/24 | 06/29 | | |
| Recruiting | N/A | 15 | US | AltaValve | 4C Medical Technologies, Inc. | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence | 09/25 | 09/25 | | |
NCT03142152: The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR |
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| Recruiting | N/A | 300 | Europe, US | Carillon Mitral Contour System, Carillon, Percutaneous mitral valve repair, Guideline Directed Heart Failure Medication | Cardiac Dimensions, Inc. | Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases | 12/26 | 12/30 | | |
Scott, Rachel K |
EBONI, NCT05514509: A Study Evaluating Implementation Strategies for the Delivery of APRETUDE for Black cis-and Transgender Women in United States EHE Territories |
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| Recruiting | 4 | 250 | US | APRETUDE, Cabotegravir tablet | ViiV Healthcare | HIV Infections | 09/25 | 09/25 | | |
Travis, Taryn |
NCT04877756: Study to Evaluate Efficacy of OLX10010 in Reducing Recurrence of Hypertrophic Scarring After Scar Revision Surgery |
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| Completed | 2 | 22 | US | OLX10010, a cell penetrating asymmetric small interference RNA (cp-asiRNA), targeting a gene involved in formation of fibrosis | Olix Pharmaceuticals, Inc., Alira Health | Hypertrophic Scar | 01/23 | 07/23 | | |
Haider, Syed A |
| Active, not recruiting | 2 | 25 | US | CardiolRx | Cardiol Therapeutics Inc. | Recurrent Pericarditis | 06/24 | 09/24 | | |
NCT05412030: A Phase 2 Study to Evaluate the Safety, Tolerability, and Immunogenicity of AFX3772 Vaccine in Healthy Infants |
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| Recruiting | 2 | 121 | US | Prevnar 13, AFX3772 | GlaxoSmithKline, Affinivax, Inc. | Pneumonia, Bacterial, Pneumococcal Infections, Pneumonia, Pneumococcal | 07/26 | 07/26 | | |
RESCUE3, NCT03783884: A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning From Mechanical Ventilation |
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| Terminated | N/A | 223 | Europe, US | Lungpacer Diaphragm Pacing Therapy, Lungpacer DPTS, AeroPace System | Lungpacer Medical Inc. | Ventilator Induced Diaphragm Dysfunction | 12/22 | 01/23 | | |
Moriarty, Terry |
| Recruiting | 3 | 200 | Europe, Canada, US, RoW | Bentracimab (PB2452) Infusion | SFJ Pharmaceuticals, Inc. | Hemorrhage, Urgent Surgery, Invasive Procedure | 08/24 | 08/24 | | |
NCT05123755: Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia. |
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| Recruiting | 2a | 120 | US | AV-001 Injection, AV-001 Placebo Injection | Vasomune Therapeutics, Inc. | Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral, Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome | 12/24 | 03/25 | | |
NCT05046158: Diabetic Foot Ulcers-Comparing Transforming Powder to Standard of Care |
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| Recruiting | N/A | 200 | US | Transforming Powder Dressing, Altrazeal, Standard of care topical wound agents and dressings | ULURU Inc., Naval Medical Research Center, Military Technology Enterprise Consortium (US) | Diabetic Foot Ulcer | 12/23 | 12/23 | | |
Ghazi, Adline |
QWINT-4, NCT05462756 / 2021-005878-25: A Study of Insulin Efsitora Alfa (LY3209590) as a Weekly Basal Insulin Compared to Insulin Glargine in Adult Participants With Type 2 Diabetes on Multiple Daily Injections |
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| Completed | 3 | 730 | Europe, US, RoW | Insulin Efsitora Alfa, LY3209590 and Basal Insulin-FC, Insulin Lispro (U100), Humalog, Insulin Glargine (U100), Basaglar | Eli Lilly and Company, Eli Lilly and Company | Type 2 Diabetes, Type 2 Diabetes Treated With Insulin | 02/24 | 02/24 | | |
NCT06292013: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a) |
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| Recruiting | 3 | 12500 | Europe, Canada, Japan, US, RoW | Lepodisiran Sodium, LY3819469, Placebo | Eli Lilly and Company | Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a) | 03/29 | 03/29 | | |
NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES) |
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| Recruiting | 3 | 10000 | Europe, Canada, US, RoW | Retatrutide, LY3437943, Placebo | Eli Lilly and Company | Overweight and Obesity | 02/29 | 02/29 | | |
ATTAIN-2, NCT05872620: A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes |
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| Active, not recruiting | 3 | 1500 | Europe, US, RoW | Orforglipron, LY3502970, Placebo | Eli Lilly and Company | Obesity, Overweight, Type 2 Diabetes | 06/25 | 06/25 | | |
| Recruiting | N/A | 240 | US | EndoBarrier Liner, EndoBarrier Sleeve, Duodenal-jejunal Bypass Liner (DJBL), Sham | GI Dynamics, Biostatistical Consulting, Inc. | Diabetes type2, Obesity | 04/24 | 04/25 | | |
Park, Jean |
TRANSCEND-T2D-2, NCT06260722: Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor |
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| Recruiting | 3 | 1250 | Canada, US, RoW | Retatrutide, LY3437943, Semaglutide | Eli Lilly and Company | Diabetes Mellitus, Type 2 | 12/26 | 03/27 | | |
NCT06292013: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a) |
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| Recruiting | 3 | 12500 | Europe, Canada, Japan, US, RoW | Lepodisiran Sodium, LY3819469, Placebo | Eli Lilly and Company | Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a) | 03/29 | 03/29 | | |
QWINT-2, NCT05362058: A Study of Insulin Efsitora Alfa (LY3209590) Compared to Degludec in Adults With Type 2 Diabetes Who Are Starting Basal Insulin for the First Time |
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| Completed | 3 | 928 | Europe, Canada, Japan, US, RoW | Insulin Efsitora Alfa, LY3209590 and Basal Insulin-FC, Insulin Degludec | Eli Lilly and Company | Diabetes, Type 2 Diabetes | 04/24 | 04/24 | | |
NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES) |
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| Recruiting | 3 | 10000 | Europe, Canada, US, RoW | Retatrutide, LY3437943, Placebo | Eli Lilly and Company | Overweight and Obesity | 02/29 | 02/29 | | |
QWINT-5, NCT05463744: A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapy |
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| Completed | 3 | 692 | Europe, Japan, US, RoW | Insulin Efsitora Alfa, LY3209590 and Basal Insulin-FC, Insulin Degludec | Eli Lilly and Company | Type 1 Diabetes, Diabetes | 05/24 | 05/24 | | |
ATTAIN-1, NCT05869903: A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities |
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| Active, not recruiting | 3 | 3000 | Europe, Japan, US, RoW | Orforglipron, LY3502970, Placebo | Eli Lilly and Company | Obesity, Overweight, Overweight or Obesity | 09/25 | 09/27 | | |
| Active, not recruiting | 3 | 9541 | Europe, Canada, Japan, US, RoW | Obicetrapib, Placebo | NewAmsterdam Pharma, Monash University | Atherosclerotic Cardiovascular Disease | 11/26 | 11/26 | | |
NCT05343065: A Continuous Glucose Monitor Based Insulin Bolus Calculator (CGM-IBC) Study B |
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| Completed | N/A | 27 | US | BlueStar 10 | Welldoc | Diabetes Mellitus | 12/22 | 12/22 | | |
| Recruiting | N/A | 240 | US | EndoBarrier Liner, EndoBarrier Sleeve, Duodenal-jejunal Bypass Liner (DJBL), Sham | GI Dynamics, Biostatistical Consulting, Inc. | Diabetes type2, Obesity | 04/24 | 04/25 | | |
NCT05238142: In-Home Study With MiniMed™ 780G Pump Automated Control in Type 2-Evaluation of the AHCL System in Adults With Insulin-requiring Type 2 Diabetes |
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| Recruiting | N/A | 575 | US | MiniMed™ 780G Insulin Pump system | Medtronic Diabetes | Type 2 Diabetes Treated With Insulin | 10/24 | 02/25 | | |
Moriarty, Theresa |
| Active, not recruiting | 2/3 | 125 | Canada, US | LAU-7b, fenretinide, Placebo oral capsule | Laurent Pharmaceuticals Inc. | COVID-19 Disease | 02/24 | 05/24 | | |
| Recruiting | 2/3 | 180 | US | Anti-BK polyomavirus (AntiBKV) | Memo Therapeutics AG | BK Viremia; BKV DNAemia | 11/24 | 11/24 | | |
| Recruiting | 2b | 126 | US | Phage Therapy, Placebo | Adaptive Phage Therapeutics, Inc., United States Department of Defense | Osteomyelitis, Diabetic Foot Osteomyelitis | 04/24 | 12/24 | | |
SEPSIS-SHIELD, NCT04094818: HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections and Suspected Sepsis |
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| Recruiting | N/A | 1500 | Europe, US | HostDx Sepsis | Inflammatix | Respiratory Tract Infections, Urinary Tract Infections, Intra-Abdominal Infections, Skin and Soft Tissue Infection, Suspected Meningitis/Encephalitis or Any Other Infection, Sepsis | 05/24 | 05/24 | | |
NCT05176899: Real-World Evaluation of Eko Murmur Analysis Software in a Point of Care Setting |
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| Recruiting | N/A | 1200 | US | Use of Eko CORE electronic stethoscope | Eko Devices, Inc. | Murmur, Heart, Innocent Murmurs, Heart Murmurs, Pathologic Murmur | 11/23 | 11/23 | | |
NCT05046158: Diabetic Foot Ulcers-Comparing Transforming Powder to Standard of Care |
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| Recruiting | N/A | 200 | US | Transforming Powder Dressing, Altrazeal, Standard of care topical wound agents and dressings | ULURU Inc., Naval Medical Research Center, Military Technology Enterprise Consortium (US) | Diabetic Foot Ulcer | 12/23 | 12/23 | | |
Rao, Sriram |
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study |
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| Recruiting | N/A | 400 | Europe, US, RoW | AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy | Ancora Heart, Inc. | Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy | 06/24 | 12/30 | | |
Bevara, Mounica |
NCT04877756: Study to Evaluate Efficacy of OLX10010 in Reducing Recurrence of Hypertrophic Scarring After Scar Revision Surgery |
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| Completed | 2 | 22 | US | OLX10010, a cell penetrating asymmetric small interference RNA (cp-asiRNA), targeting a gene involved in formation of fibrosis | Olix Pharmaceuticals, Inc., Alira Health | Hypertrophic Scar | 01/23 | 07/23 | | |
Matar, Noor |
VISTAS, NCT04663308: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC) |
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| Recruiting | 2 | 200 | Europe, Canada, US, RoW | Volixibat, SHP626, Placebo | Mirum Pharmaceuticals, Inc. | Primary Sclerosing Cholangitis | 09/25 | 12/25 | | |
| Recruiting | N/A | 175 | Europe, US | Partial Rebreathing Device, Sham breathing device | Rehaler, Qmed Consulting A/S | Migraine With Aura | 10/24 | 10/25 | | |