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 59 Trials 
113 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Wortmann, Glenn
REPAVID-22, NCT05254990 / 2021-006951-32: Reparixin add-on Therapy to Std Care to Limit Progression in Pts With COVID19 & Other Community Acquired Pneumonia

Recruiting
3
526
Europe, US, RoW
Reparixin, Repertaxin L-lysine salt, Placebo, Matched placebo
Dompé Farmaceutici S.p.A
Infectious Pneumonia, Severe COVID-19
09/24
10/24
RESOLUTION, NCT04417257: Study of LAU-7b for the Treatment of COVID-19 Disease in Adults

Active, not recruiting
2/3
125
Canada, US
LAU-7b, fenretinide, Placebo oral capsule
Laurent Pharmaceuticals Inc.
COVID-19 Disease
02/24
05/24
APT.DFO.001, NCT05177107: Bacteriophage Therapy in Patients With Diabetic Foot Osteomyelitis

Recruiting
2b
126
US
Phage Therapy, Placebo
Adaptive Phage Therapeutics, Inc., United States Department of Defense
Osteomyelitis, Diabetic Foot Osteomyelitis
04/24
12/24
Thourani, Vinod
NCT02732691: JENAVALVE AS EFS TRIAL: Pericardial TAVR Aortic Stenosis Study

Active, not recruiting
N/A
68
Europe, US, RoW
JenaValve Pericardial TAVR System
JenaValve Technology, Inc.
Aortic Valve Stenosis, Heart Valve Diseases, Heart Diseases, Cardiovascular Diseases, Ventricular Outflow Obstruction
05/19
04/24
ACTIVE, NCT03016975: Edwards Cardioband System Pivotal Clinical Trial

Terminated
N/A
12
US
Edwards Cardioband System, Transcatheter mitral valve repair (TMVr), Guideline Directed Medical Therapy
Edwards Lifesciences
Functional Mitral Regurgitation, Mitral Regurgitation, Mitral Insufficiency
07/19
09/22
NCT03539458: Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification

Active, not recruiting
N/A
11
US
Tendyne Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Annular Calcification, Mitral Annulus Calcification, Cardiovascular Diseases, Valve Heart Disease, Heart Valve Diseases, Heart Valve Calcification, Mitral Valve Disease
11/19
10/24
NCT02732704: THE ALIGN-AR EFS TRIAL: JenaValve Pericardial TAVR Aortic Regurgitation Study

Active, not recruiting
N/A
100
Europe, US
JenaValve Pericardial TAVR System
JenaValve Technology, Inc.
Aortic Regurgitation
08/22
09/27
ALIGN-AR, NCT04415047: The JenaValve Pivotal Trial

Active, not recruiting
N/A
180
US
JenaValve Trilogy Heart Valve System
JenaValve Technology, Inc.
Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency, Aortic Valve Disease
08/23
08/28
RESTORE, NCT04375332: Beating Heart Mitral Valve Repair With the HARPOON™ System

Active, not recruiting
N/A
25
Canada, US
HARPOON™ Beating Heart Mitral Valve Repair System
Edwards Lifesciences
Mitral Regurgitation
10/23
12/27
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
01/25
04/30
NCT04905017: Trisol System EFS Study

Recruiting
N/A
15
US
Transcatheter Tricuspid Valve Replacement
Trisol Medical
Tricuspid Regurgitation
01/25
07/27
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
06/24
06/28
NCT05061004: Cephea Early Feasibility Study

Recruiting
N/A
30
Canada, US
Cephea Mitral Valve System
Abbott Medical Devices
Mitral Regurgitation
06/24
06/29
NCT04482062: TRISCEND II Pivotal Trial

Recruiting
N/A
1070
Europe, US
Edwards EVOQUE System, Transcatheter tricuspid valve replacement, Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure
06/24
12/29
NCT05913908: EFS of the DUO System for Tricuspid Regurgitation (TANDEM II)

Recruiting
N/A
15
US
DUO Transcatheter Tricuspid Coaptation Valve System, DUO System
CroiValve Limited
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases
04/25
10/29
CLASP II TR, NCT04097145: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Recruiting
N/A
870
Canada, US
Edwards PASCAL System, Transcatheter tricuspid valve repair (TTVr), Optimal Medical Therapy
Edwards Lifesciences
Tricuspid Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease
12/24
03/29
NCT03382457: Clinical Study of Edwards Cardioband Tricuspid Valve Reconstruction System

Active, not recruiting
N/A
55
US
Transcatheter Tricuspid Valve Reconstruction, Edwards Cardioband Tricuspid Valve Reconstruction
Edwards Lifesciences
Tricuspid Regurgitation
01/25
01/30
NCT04198870: MitraClip REPAIR MR Study

Recruiting
N/A
500
Europe, Canada, US
MitraClip™ device implantation, Mitral Valve Repair Surgery
Abbott Medical Devices
Mitral Valve Regurgitation
04/26
04/34
MOMENTIS, NCT05526560: Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve

Active, not recruiting
N/A
500
Canada, US
MITRIS RESILIA Mitral Valve, Model 11400M
Edwards Lifesciences
Mitral Stenosis, Mitral Valve Insufficiency
01/28
12/35
LeAAPS, NCT05478304: Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

Recruiting
N/A
6500
Europe, Canada, US
AtriClip LAA Exclusion System
AtriCure, Inc., Population Health Research Institute
Ischemic Stroke, Systemic Embolism
12/31
04/32
Shupp, Jeffrey
NCT05156983: A Study of TAK-330 for Reversal of Direct Oral Factor Xa Inhibitor-induced Anticoagulation

Recruiting
3
328
Europe, Canada, US
TAK-330, SOC 4F-PCC
Takeda, Takeda Development Center Americas, Inc.
Coagulation Disorder
11/25
11/25
NCT04040660: Use of NexoBrid for Treatment of Acute Deep Partial and Full Thickness Burn Injuries

Available
N/A
US
NexoBrid
MediWound Ltd
Thermal Burn
 
 
NCT05023135: DeepView SnapShot Portable (DV-SSP): Device Training Study

Completed
N/A
251
US
DeepView SnapShot Portable (DV-SSP)
SpectralMD
Burns, Wound Heal
04/23
04/23
Bernardo, Nelson
NCT05055297: SELUTION4BTK Trial

Recruiting
N/A
376
Europe, US, RoW
SELUTION SLR™ DEB 014, Plain (Uncoated) Balloon Angioplasty (PTA)
MedAlliance, LLC, NAMSA
Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia Nos of Native Arteries of Extremities
11/24
07/28
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting
N/A
1400
Europe, US, RoW
Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation
Medtronic Vascular
Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus
11/26
11/29
NCT05132361: SELUTION4SFA Trial

Recruiting
N/A
300
Europe, US, RoW
SELUTION SLR™ 018 DEB, Plain (Uncoated) Balloon Angioplasty (PTA)
MedAlliance, LLC, NAMSA
Peripheral Arterial Disease, Superficial Femoral Artery Stenosis
12/24
12/29
NCT04543539: IN.PACT™ AV Access Post-Approval Study (PAS002)

Recruiting
N/A
240
US
IN.PACT™ AV Drug Coated Balloon (DCB) - Primary Cohort, IN.PACT™ AV Drug Coated Balloon (DCB) - Extended Cohort
Medtronic
Arteriovenous Fistula, Arteriovenous Fistula Stenosis, Arteriovenous Fistula Occlusion, Fistula
02/25
02/29
Patchen, Loral
KULEA-NET, NCT05985876: A Mobile Application for African American/Black Mothers to Promote Exclusive and Continuous Breastfeeding

Enrolling by invitation
2
523
US
KULEA-NET application, Control Group: Usual Care
Benten Technologies, Inc., George Washington University, Medstar Health Research Institute, National Institute on Minority Health and Health Disparities (NIMHD)
Breastfeeding, Exclusive Breastfeeding
04/24
05/24
Goyal, Munish
REVERSE-IT, NCT04286438 / 2019-004457-92: Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

Recruiting
3
200
Europe, Canada, US, RoW
Bentracimab (PB2452) Infusion
SFJ Pharmaceuticals, Inc.
Hemorrhage, Urgent Surgery, Invasive Procedure
08/24
08/24
Ailani, Jessica
PAREMA1, NCT05546385: PArtial REbreathing for Migraine With Aura 1

Recruiting
N/A
175
Europe, US
Partial Rebreathing Device, Sham breathing device
Rehaler, Qmed Consulting A/S
Migraine With Aura
10/24
10/25
Franchi, Francesco
OPTIMUS-7, NCT04484259: Ticagrelor With and Without Aspirin in Patients With Diabetes Mellitus

Active, not recruiting
4
105
US
Ticagrelor monotherapy, Brilinta, Ticagrelor plus aspirin, Clopidogrel with aspirin, Plavix
University of Florida, AstraZeneca
Diabetes Mellitus, Type 2, Coronary Artery Disease
01/24
08/24
REVERSE-IT, NCT04286438 / 2019-004457-92: Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

Recruiting
3
200
Europe, Canada, US, RoW
Bentracimab (PB2452) Infusion
SFJ Pharmaceuticals, Inc.
Hemorrhage, Urgent Surgery, Invasive Procedure
08/24
08/24
VICTORION-2P, NCT05030428: Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease

Active, not recruiting
3
17006
Europe, Canada, Japan, US, RoW
Inclisiran sodium 300 mg, Placebo
Novartis Pharmaceuticals
Atherosclerotic Cardiovascular Disease
10/27
10/27
VICTORION-1 PREVENT, NCT05739383: A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.

Recruiting
3
14000
Europe, Canada, US, RoW
Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL, KJX839, Placebo in 1.5ml
Novartis Pharmaceuticals
Primary Prevention of Atherosclerotic Cardiovascular Disease
04/29
04/29
Ohanian, Arbi G
PAREMA1, NCT05546385: PArtial REbreathing for Migraine With Aura 1

Recruiting
N/A
175
Europe, US
Partial Rebreathing Device, Sham breathing device
Rehaler, Qmed Consulting A/S
Migraine With Aura
10/24
10/25
Pokharel, Shreejana
NCT02438306: CardiAMP™ Cell Therapy for Heart Failure Trial

Active, not recruiting
3
125
Canada, US
Autologous cell therapy, Sham
BioCardia, Inc.
Heart Failure, Systolic
12/24
12/26
Fatima, Javairiah
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
08/24
10/29
TAMBE, NCT05442489: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of the Thoracoabdominal and Pararenal Aortic Aneurysms

Available
N/A
US
GORE Excluder Thoracoabdominal Branch Endoprosthesis, TAMBE
W.L.Gore & Associates
Thoracoabdominal Aneurysm
 
 
SSB 11-02, NCT02777528: Evaluation of the GORE® TAG® Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta (Zone 0/1)

Active, not recruiting
N/A
150
Japan, US
GORE® TAG® Thoracic Branch Endoprosthesis, Revascularization Procedure
W.L.Gore & Associates
Aortic Aneurysm, Thoracic, Aorta, Lesion
03/24
03/28
NCT04875429: Zenith® Fenestrated+ Clinical Study

Recruiting
N/A
102
US
Zenith Fenestrated+ Endovascular Graft in combination with the BeGraft Balloon-Expandable FEVAR Bridging Stent Graft System and Unibody2
Cook Research Incorporated
Aortic Aneurysm, Abdominal, Juxtarenal Aortic Aneurysm, Extent IV Thoracoabdominal, Pararenal Aneurysm
06/26
04/31
TAMBE, NCT03728985: Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms

Recruiting
N/A
122
Europe, US
GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis, TAMBE
W.L.Gore & Associates
Thoracoabdominal Aortic Aneurysm
06/26
09/26
TREO PAS, NCT04697784: Post-Approval Study of the TREO Abdominal Stent-Graft System

Recruiting
N/A
300
US
TREO Abdominal Stent-Graft System
Bolton Medical
Abdominal Aortic Aneurysm
07/27
07/27
Singh, Suman
stAAAble, NCT06001918: Nectero EAST System Clinical Study

Recruiting
2/3
400
US
Nectero EAST System
Nectero Medical, Inc.
Abdominal Aortic Aneurysm
03/27
12/29
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
08/24
10/29
NCT05198674: SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Recruiting
N/A
1400
Europe, US, RoW
Renal Denervation (Symplicity Spyral™), Renal Angiography, Renal Denervation
Medtronic Vascular
Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus
11/26
11/29
CLEAN-PE, NCT06189313: CLEANer Aspiration for Pulmonary Embolism

Not yet recruiting
N/A
125
US
Cleaner Pro Thrombectomy System, Cleaner Vac Thrombectomy System
Argon Medical Devices, NAMSA
Pulmonary Embolism, Acute Pulmonary Embolism, Cardiovascular Diseases, Venous Thromboembolism
07/25
08/25
NCT05409976: The GORE® VIAFORT Vascular Stent IVC Study

Recruiting
N/A
111
Europe, US, RoW
GORE® VIAFORT Vascular Stent
W.L.Gore & Associates
Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease
01/25
01/29
NCT05489588: The GORE® VIAFORT Vascular Stent Iliofemoral Study

Recruiting
N/A
165
US
GORE® VIAFORT Vascular Stent
W.L.Gore & Associates
Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis, Venous Ulcer, Venous Stenosis, Venous Occlusion, Vein Thrombosis, Vein Occlusion, Vein Disease
04/25
04/29
Bethea, Brian
NCT03904147: TRILUMINATE Pivotal Trial

Active, not recruiting
N/A
572
Europe, Canada, US
TriClipTM Device
Abbott Medical Devices
Tricuspid Regurgitation
11/22
04/29
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
06/24
06/28
Shults, Christian
ReChord, NCT02803957: Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair

Recruiting
N/A
585
US
NeoChord DS1000, Surgical Mitral Valve Repair
NeoChord
Mitral Valve Insufficiency
07/22
07/27
TRIOMPHE, NCT04471909: NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

Recruiting
N/A
110
US, RoW
NEXUS Aortic Stent Graft System
Endospan Ltd.
Aortic Dissection, Aortic Aneurysm, Intramural Hematoma, Penetrating Aortic Ulcer
08/24
10/29
STAR-T, NCT04976530: Safe and Timely Antithrombotic Removal - Ticagrelor

Completed
N/A
140
Canada, US
DrugSorb-ATR system, Sorbent hemoperfusion system, Sham comparator
CytoSorbents, Inc
Hemorrhage, Surgical, Blood Loss, Surgical, Blood Loss, Postoperative, Hemorrhage Postoperative
08/23
08/23
NCT03033043: Study of the RelayPro Thoracic Stent-Graft in Subjects With an Acute, Complicated Type B Aortic Dissection

Active, not recruiting
N/A
56
US
Relay Pro Stent-Graft, Relay Pro Stent Graft System
Bolton Medical
Aortic Dissection Type B
10/21
10/26
NCT03997305: AltaValve Early Feasibility Study Protocol

Recruiting
N/A
15
US
AltaValve
4C Medical Technologies, Inc.
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
09/25
09/25
NCT05280093: HEAL-IST IDE Trial

Recruiting
N/A
142
Europe, US
AtriCure ISOLATOR Synergy Surgical Ablation System
AtriCure, Inc.
Inappropriate Sinus Tachycardia
06/26
06/27
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

Recruiting
N/A
1056
Europe, Canada, US
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Medtronic Cardiovascular
Mitral Valve Regurgitation
10/26
09/36
EXTEND, NCT05639400: Thoraflex Hybrid and Relay Extension Post-Approval Study

Recruiting
N/A
200
Europe, US
Thoraflex Hybrid, RelayPro NBS
Vascutek Ltd., Bolton Medical
Thoracic Diseases, Aortic Aneurysm, Aortic Dissection, Thoracic Aortic Aneurysm, Thoracic Aortic Dissection
12/35
12/36
Olano, Arrel
NCT05176899: Real-World Evaluation of Eko Murmur Analysis Software in a Point of Care Setting

Recruiting
N/A
1200
US
Use of Eko CORE electronic stethoscope
Eko Devices, Inc.
Murmur, Heart, Innocent Murmurs, Heart Murmurs, Pathologic Murmur
11/23
11/23
Kanth, Priyanka
NCT05625529: ExoLuminate Study for Early Detection of Pancreatic Cancer

Recruiting
N/A
1000
US
Biological Dynamics, Medical College of Wisconsin, Dana-Farber Cancer Institute
Pancreas Cancer, Exosomes, Extracellular Vesicles, Pancreatic Neoplasms
01/26
01/27
Moyer, Keith
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Recruiting
N/A
958
Canada, US
Tendyne Mitral Valve System, MitraClip System
Abbott Medical Devices
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
06/24
06/28
CATALYST, NCT04226547: Amplatzer Amulet LAAO vs. NOAC

Recruiting
N/A
2650
Europe, Canada, Japan, US, RoW
Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC
Abbott Medical Devices
Atrial Fibrillation, Stroke, Bleeding
08/27
08/30
Khurana, Neal
CLEAN-PE, NCT06189313: CLEANer Aspiration for Pulmonary Embolism

Not yet recruiting
N/A
125
US
Cleaner Pro Thrombectomy System, Cleaner Vac Thrombectomy System
Argon Medical Devices, NAMSA
Pulmonary Embolism, Acute Pulmonary Embolism, Cardiovascular Diseases, Venous Thromboembolism
07/25
08/25
Collins, Erin
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
01/25
04/30
JVTF EFS, NCT06034028: J-Valve TF Early Feasibility Study

Recruiting
N/A
25
US
J-Valve TF System
JC Medical, Inc.
Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Regurgitation
03/24
06/29
NCT03997305: AltaValve Early Feasibility Study Protocol

Recruiting
N/A
15
US
AltaValve
4C Medical Technologies, Inc.
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence
09/25
09/25
NCT03142152: The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Recruiting
N/A
300
Europe, US
Carillon Mitral Contour System, Carillon, Percutaneous mitral valve repair, Guideline Directed Heart Failure Medication
Cardiac Dimensions, Inc.
Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
12/26
12/30
Scott, Rachel K
EBONI, NCT05514509: A Study Evaluating Implementation Strategies for the Delivery of APRETUDE for Black cis-and Transgender Women in United States EHE Territories

Recruiting
4
250
US
APRETUDE, Cabotegravir tablet
ViiV Healthcare
HIV Infections
09/25
09/25
Travis, Taryn
NCT04877756: Study to Evaluate Efficacy of OLX10010 in Reducing Recurrence of Hypertrophic Scarring After Scar Revision Surgery

Completed
2
22
US
OLX10010, a cell penetrating asymmetric small interference RNA (cp-asiRNA), targeting a gene involved in formation of fibrosis
Olix Pharmaceuticals, Inc., Alira Health
Hypertrophic Scar
01/23
07/23
Haider, Syed A
MAvERIC, NCT05494788: Impact of CardiolRxTM on Recurrent Pericarditis (-Pilot)

Active, not recruiting
2
25
US
CardiolRx
Cardiol Therapeutics Inc.
Recurrent Pericarditis
06/24
09/24
NCT05412030: A Phase 2 Study to Evaluate the Safety, Tolerability, and Immunogenicity of AFX3772 Vaccine in Healthy Infants

Recruiting
2
121
US
Prevnar 13, AFX3772
GlaxoSmithKline, Affinivax, Inc.
Pneumonia, Bacterial, Pneumococcal Infections, Pneumonia, Pneumococcal
07/26
07/26
RESCUE3, NCT03783884: A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning From Mechanical Ventilation

Terminated
N/A
223
Europe, US
Lungpacer Diaphragm Pacing Therapy, Lungpacer DPTS, AeroPace System
Lungpacer Medical Inc.
Ventilator Induced Diaphragm Dysfunction
12/22
01/23
Moriarty, Terry
REVERSE-IT, NCT04286438 / 2019-004457-92: Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure

Recruiting
3
200
Europe, Canada, US, RoW
Bentracimab (PB2452) Infusion
SFJ Pharmaceuticals, Inc.
Hemorrhage, Urgent Surgery, Invasive Procedure
08/24
08/24
NCT05123755: Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.

Recruiting
2a
120
US
AV-001 Injection, AV-001 Placebo Injection
Vasomune Therapeutics, Inc.
Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral, Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
12/24
03/25
NCT05046158: Diabetic Foot Ulcers-Comparing Transforming Powder to Standard of Care

Recruiting
N/A
200
US
Transforming Powder Dressing, Altrazeal, Standard of care topical wound agents and dressings
ULURU Inc., Naval Medical Research Center, Military Technology Enterprise Consortium (US)
Diabetic Foot Ulcer
12/23
12/23
Ghazi, Adline
QWINT-4, NCT05462756 / 2021-005878-25: A Study of Insulin Efsitora Alfa (LY3209590) as a Weekly Basal Insulin Compared to Insulin Glargine in Adult Participants With Type 2 Diabetes on Multiple Daily Injections

Completed
3
730
Europe, US, RoW
Insulin Efsitora Alfa, LY3209590 and Basal Insulin-FC, Insulin Lispro (U100), Humalog, Insulin Glargine (U100), Basaglar
Eli Lilly and Company, Eli Lilly and Company
Type 2 Diabetes, Type 2 Diabetes Treated With Insulin
02/24
02/24
NCT06292013: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Recruiting
3
12500
Europe, Canada, Japan, US, RoW
Lepodisiran Sodium, LY3819469, Placebo
Eli Lilly and Company
Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a)
03/29
03/29
NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES)

Recruiting
3
10000
Europe, Canada, US, RoW
Retatrutide, LY3437943, Placebo
Eli Lilly and Company
Overweight and Obesity
02/29
02/29
ATTAIN-2, NCT05872620: A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes

Active, not recruiting
3
1500
Europe, US, RoW
Orforglipron, LY3502970, Placebo
Eli Lilly and Company
Obesity, Overweight, Type 2 Diabetes
06/25
06/25
STEP-1, NCT04101669: EndoBarrier System Pivotal Trial(Rev E v2)

Recruiting
N/A
240
US
EndoBarrier Liner, EndoBarrier Sleeve, Duodenal-jejunal Bypass Liner (DJBL), Sham
GI Dynamics, Biostatistical Consulting, Inc.
Diabetes type2, Obesity
04/24
04/25
Park, Jean
TRANSCEND-T2D-2, NCT06260722: Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor

Recruiting
3
1250
Canada, US, RoW
Retatrutide, LY3437943, Semaglutide
Eli Lilly and Company
Diabetes Mellitus, Type 2
12/26
03/27
NCT06292013: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Recruiting
3
12500
Europe, Canada, Japan, US, RoW
Lepodisiran Sodium, LY3819469, Placebo
Eli Lilly and Company
Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a)
03/29
03/29
QWINT-2, NCT05362058: A Study of Insulin Efsitora Alfa (LY3209590) Compared to Degludec in Adults With Type 2 Diabetes Who Are Starting Basal Insulin for the First Time

Completed
3
928
Europe, Canada, Japan, US, RoW
Insulin Efsitora Alfa, LY3209590 and Basal Insulin-FC, Insulin Degludec
Eli Lilly and Company
Diabetes, Type 2 Diabetes
04/24
04/24
NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES)

Recruiting
3
10000
Europe, Canada, US, RoW
Retatrutide, LY3437943, Placebo
Eli Lilly and Company
Overweight and Obesity
02/29
02/29
QWINT-5, NCT05463744: A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapy

Completed
3
692
Europe, Japan, US, RoW
Insulin Efsitora Alfa, LY3209590 and Basal Insulin-FC, Insulin Degludec
Eli Lilly and Company
Type 1 Diabetes, Diabetes
05/24
05/24
ATTAIN-1, NCT05869903: A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities

Active, not recruiting
3
3000
Europe, Japan, US, RoW
Orforglipron, LY3502970, Placebo
Eli Lilly and Company
Obesity, Overweight, Overweight or Obesity
09/25
09/27
PREVAIL, NCT05202509 / 2021-005092-39: Cardiovascular Outcome Study to Evaluate the Effect of Obicetrapib in Patients With Cardiovascular Disease

Active, not recruiting
3
9541
Europe, Canada, Japan, US, RoW
Obicetrapib, Placebo
NewAmsterdam Pharma, Monash University
Atherosclerotic Cardiovascular Disease
11/26
11/26
NCT05343065: A Continuous Glucose Monitor Based Insulin Bolus Calculator (CGM-IBC) Study B

Completed
N/A
27
US
BlueStar 10
Welldoc
Diabetes Mellitus
12/22
12/22
STEP-1, NCT04101669: EndoBarrier System Pivotal Trial(Rev E v2)

Recruiting
N/A
240
US
EndoBarrier Liner, EndoBarrier Sleeve, Duodenal-jejunal Bypass Liner (DJBL), Sham
GI Dynamics, Biostatistical Consulting, Inc.
Diabetes type2, Obesity
04/24
04/25
NCT05238142: In-Home Study With MiniMed™ 780G Pump Automated Control in Type 2-Evaluation of the AHCL System in Adults With Insulin-requiring Type 2 Diabetes

Recruiting
N/A
575
US
MiniMed™ 780G Insulin Pump system
Medtronic Diabetes
Type 2 Diabetes Treated With Insulin
10/24
02/25
Moriarty, Theresa
RESOLUTION, NCT04417257: Study of LAU-7b for the Treatment of COVID-19 Disease in Adults

Active, not recruiting
2/3
125
Canada, US
LAU-7b, fenretinide, Placebo oral capsule
Laurent Pharmaceuticals Inc.
COVID-19 Disease
02/24
05/24
SAFE KIDNEY II, NCT05769582: Safety, Tolerability and Efficacy of AntiBKV as Treatment of BKV Infection in Kidney Transplant Recipients

Recruiting
2/3
180
US
Anti-BK polyomavirus (AntiBKV)
Memo Therapeutics AG
BK Viremia; BKV DNAemia
11/24
11/24
APT.DFO.001, NCT05177107: Bacteriophage Therapy in Patients With Diabetic Foot Osteomyelitis

Recruiting
2b
126
US
Phage Therapy, Placebo
Adaptive Phage Therapeutics, Inc., United States Department of Defense
Osteomyelitis, Diabetic Foot Osteomyelitis
04/24
12/24
SEPSIS-SHIELD, NCT04094818: HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections and Suspected Sepsis

Recruiting
N/A
1500
Europe, US
HostDx Sepsis
Inflammatix
Respiratory Tract Infections, Urinary Tract Infections, Intra-Abdominal Infections, Skin and Soft Tissue Infection, Suspected Meningitis/Encephalitis or Any Other Infection, Sepsis
05/24
05/24
NCT05176899: Real-World Evaluation of Eko Murmur Analysis Software in a Point of Care Setting

Recruiting
N/A
1200
US
Use of Eko CORE electronic stethoscope
Eko Devices, Inc.
Murmur, Heart, Innocent Murmurs, Heart Murmurs, Pathologic Murmur
11/23
11/23
NCT05046158: Diabetic Foot Ulcers-Comparing Transforming Powder to Standard of Care

Recruiting
N/A
200
US
Transforming Powder Dressing, Altrazeal, Standard of care topical wound agents and dressings
ULURU Inc., Naval Medical Research Center, Military Technology Enterprise Consortium (US)
Diabetic Foot Ulcer
12/23
12/23
Rao, Sriram
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study

Recruiting
N/A
400
Europe, US, RoW
AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy
Ancora Heart, Inc.
Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
06/24
12/30
Bevara, Mounica
NCT04877756: Study to Evaluate Efficacy of OLX10010 in Reducing Recurrence of Hypertrophic Scarring After Scar Revision Surgery

Completed
2
22
US
OLX10010, a cell penetrating asymmetric small interference RNA (cp-asiRNA), targeting a gene involved in formation of fibrosis
Olix Pharmaceuticals, Inc., Alira Health
Hypertrophic Scar
01/23
07/23
Matar, Noor
VISTAS, NCT04663308: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

Recruiting
2
200
Europe, Canada, US, RoW
Volixibat, SHP626, Placebo
Mirum Pharmaceuticals, Inc.
Primary Sclerosing Cholangitis
09/25
12/25
PAREMA1, NCT05546385: PArtial REbreathing for Migraine With Aura 1

Recruiting
N/A
175
Europe, US
Partial Rebreathing Device, Sham breathing device
Rehaler, Qmed Consulting A/S
Migraine With Aura
10/24
10/25
 

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