| Nielsen, Henrik |
AVERTAS-1, NCT04904406: Changes in Weight, Body Composition and Cardiac Risk After Discontinuing Abacavir Treatment in HIV-infected Individuals |
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| Completed | 4 | 81 | Europe | Dolutegravir / Lamivudine Oral Tablet, Dolutegravir/abacavir/lamivudine | Thomas Benfield | Hiv, HIV Infections, HIV Cardiomyopathy, Weight Change, Body, HIV Lipodystrophy, Cardiovascular Diseases | 12/23 | 12/23 | | |
AVERTAS-2, NCT04903847: Changes in Weight, Body Composition and Metabolic Parameters After Discontinuing Dolutegravir or Tenofovir Disproxil |
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| Recruiting | 4 | 126 | Europe | Dolutegravir/Lamivudine 50 MG-300 MG Oral Tablet [DOVATO], Dovato, Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate 100 MG-300 MG-300 MG Oral Tablet [DELSTRIGO], Delstrigo | Thomas Benfield | Hiv, HIV Infections, HIV Lipodystrophy, Osteoporosis, Renal Insufficiency, Weight Gain, Obesity | 02/23 | 02/23 | | |
| Completed | 4 | 7600 | Europe | COMIRNATY - BioNTech Manufacturing GmbH, COVID-19 Vaccine Moderna dispersion for injection - MODERNA BIOTECH, COVID-19 Vaccine AstraZeneca suspension for injection | Jens D Lundgren, MD, Ministry of the Interior and Health, Denmark | SARS-CoV Infection | 12/23 | 12/23 | | |
| Recruiting | 4 | 380 | Europe | Shortened antibiotic treatment, Standard antibiotic treatment | Thomas Benfield | Gram-negative Bacteremia, Urinary Tract Infection Bacterial | 10/26 | 10/26 | | |
DANNOAC-AF, NCT03129490: The Danish Non-vitamin K Antagonist Oral Anticoagulation Study in Patients With Atrial Fibrillation |
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| Recruiting | 4 | 11000 | Europe | Dabigatran Etexilate Oral Capsule, Rivaroxaban Oral Tablet, Edoxaban Oral Tablet, Apixaban Oral Tablet | Herlev and Gentofte Hospital, Danish Society of Cardiology | Atrial Fibrillation, Atrial Flutter | 10/27 | 10/27 | | |
| Completed | 3 | 4223 | Europe, US | ABNCoV2, Comirnaty | Bavarian Nordic | COVID-19 Disease | 03/23 | 10/23 | | |
| Recruiting | 3 | 820 | Europe, US, RoW | Hyperimmune immunoglobulin to SARS-CoV-2 (hIVIG), Placebo | University of Minnesota, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) | COVID, SARS-CoV2 Infection, Covid19 | 08/26 | 08/26 | | |
| Recruiting | N/A | 1900 | Europe | Community-acquired CNS infections, bacterial meningitis, viral meningitis, encephalitis, brain abscess, neuroborreliosis, neurosyphilis | Aalborg University Hospital, Danish Study Group of Infections of the Brain | Central Nervous System Infections, Bacterial Meningitis, Viral Meningitis, Aseptic Meningitis, Encephalitis, Brain Abscess, Neuroborreliosis, Neurosyphilis, Lyme Disease, Tertiary Syphilis, Cerebral Abscess, Meningitis | 01/30 | 01/30 | | |
| Pfeiffer, Per |
HERES, NCT05170256: Trastuzumab and Standard Treatment With Chemo- and Immunotherapy as First Line Treatment for HER2 Positive Esophageal Squamous Cell Carcinoma Patients |
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| Recruiting | 2 | 24 | Europe | Trastuzumab | Morten Mau-Sørensen, Odense University Hospital, Aalborg University Hospital, Aarhus University Hospital | Esophageal Squamous Cell Carcinoma, HER-2 Protein Overexpression, HER-2 Gene Amplification | 01/25 | 01/25 | | |
PANTAX-Ib, NCT04652206: Clinical Trial to Investigate Safety, Tolerability and MTD for SCO-101 in Combination With Gemcitabine and Nab-paclitaxel in Inoperable Pancreatic Cancer Patients. |
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| Recruiting | 1/2 | 18 | Europe | SCO-101, Gemcitabine, Nab paclitaxel | Scandion Oncology A/S, Alcedis GmbH | Metastatic Pancreatic Adenocarcinoma, Locally Advanced Pancreatic Adenocarcinoma, Inoperable Disease, Localized Pancreatic Adenocarcinoma | 03/22 | 05/22 | | |
| Completed | 1/2 | 167 | Europe | CAN04, Cisplatin, Gemcitabine, Nab-paclitaxel, Carboplatin, Pemetrexed | Cantargia AB | Non Small Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma, Triple Negative Breast Cancer, Colorectal Cancer | 03/24 | 03/24 | | |
GARNET, NCT02715284: Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors |
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| Recruiting | 1 | 740 | Europe, Canada, US, RoW | Dostarlimab | Tesaro, Inc. | Neoplasms | 05/26 | 10/27 | | |
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PROGNOSIS-RCT, NCT04686851: Predictive Value of Geriatric Oncology Screening and Geriatric Assessment in Older Patients With Solid Cancers |
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| Recruiting | N/A | 322 | Europe | Comprehensive Geriatric Assessment and follow-up | Odense University Hospital, University of Southern Denmark, Danish Cancer Society, Academy of Geriatric Cancer, Odense Patient Data Explorative Network, Region of Southern Denmark | Frailty, Cancer, Age | 11/23 | 06/24 | | |
| Holland-Fischer, Peter |
I-HEP, NCT04810156: Treatment Efficacy of Corticosteroids and Mycophenolate Mofetil in Patients With Immune Related Hepatitis |
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| Recruiting | 2 | 60 | Europe | Mycophenolate Mofetil, Cellcept, Myfenax, Solu-Medrol, Methylprednisolone, Medrol, Corticosteroids, Steroid, Ursodeoxycholic acid, ursochol, Prednisone tablet, steroid | Inge Marie Svane | Hepatitis, Drug-Induced | 04/25 | 11/25 | | |
| Kamperis, Konstantinos |
NCT06465576: Strategy for Withdrawal of Pharmacological Treatment for Urinary Incontinence in Children (StayDry) |
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| Recruiting | 4 | 216 | Europe | Solifenacin, Mirabegron, Solifenacin + Mirabegron | University of Aarhus | Urinary Incontinence in Children | 12/27 | 12/27 | | |
NCT06551246: Efficacy of Solifenacin, Mirabegron and Combination Therapy in Children with Daytime Urinary Incontinence (BeDry) |
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| Recruiting | 3 | 236 | Europe | Solifenacin, Mirabegron | University of Aarhus | Urinary Incontinence in Children | 12/27 | 12/27 | | |
NCT04620356: Effect of Use of DryNites Absorbent Pants on the Rate of Spontaneous Resolution of Paediatric Nocturnal Enuresis (NE) |
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| Recruiting | N/A | 120 | Europe | DryNites Pyjama Pants | Kimberly-Clark Corporation | Nocturnal Enuresis | 12/22 | 12/22 | | |
| Recruiting | N/A | 100 | Europe | Polyethylene Glycol 3350, Magnesia, Laxoberal, Glyoktylklysma, Urotherapy | University of Aarhus | Bladder and Bowel Dysfunction | 12/25 | 12/25 | | |
NCT05989646: Brain Activity Among Children With Overactive Bladder and Daytime Urinary Incontinence and Healthy Children |
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| Recruiting | N/A | 65 | Europe | Sacral TENS, Urotherapy | Aalborg University Hospital, Aarhus University Hospital, Regional Hospital West Jutland, North Denmark Regional Hospital | Urinary Incontinence, Daytime Wetting, Urination Disorders, Urination Involuntary, Urologic Diseases, Lower Urinary Tract Symptoms, Urological Manifestations, Behavioral Symptoms, Mental Disorders, Elimination Disorders | 04/24 | 04/24 | | |
| Simonsen, Ole |
NCT03886259: Effects of Exercise and Education in Patients With Chronic Pain After Total Knee Replacement |
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| Completed | N/A | 71 | Europe | Neuromuscular exercises (NEMEX-TJR) and pain neuroscience education, Pain neuroscience education | Aalborg University, Northern Orthopaedic Division, Denmark, The Danish Rheumatism Association, Svend Andersen Foundation, Lions Denmark | Arthroplasty, Replacement, Knee, Chronic Pain | 02/23 | 04/24 | | |
| Møller, Søren |
| Recruiting | 3 | 450 | Europe, Canada, Japan, US, RoW | Dordaviprone (ONC201), Dordaviprone (ONC201) + Placebo, Placebo | Chimerix | H3 K27M, Glioma | 08/26 | 08/26 | | |
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| Recruiting | N/A | 44 | Europe | Repeated stereotactic radiosurgery, SRS | Rigshospitalet, Denmark | Cancer, Brain Metastases, Adult | 08/23 | 08/23 | | |
| Recruiting | N/A | 1200 | Europe | Local ablative therapy (LAT), Metastases-directed therapy | Gitte Fredberg Persson MD PhD | Oligometastatic Disease, Metastases, Ablation Techniques, Radiotherapy, Stereotactic Radiation, Surgery | 12/30 | 12/35 | | |
| Thuesen, Leif |
NCT04542460: The Nordic Baltic Chronic Total Occlusion (CTO) Arrhythmia Study |
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| Recruiting | N/A | 200 | Europe | PCI, Loop recorder | Leif Thuesen | Chronic Total Coronary Occlusion | 03/27 | 09/27 | | |
eMYHeart, NCT04172974: eHealth Intervention to Manage Depression and Anxiety in Patients With Ischemic Heart Disease |
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| Active, not recruiting | N/A | 198 | Europe | eHealth intervention, Usual Care | University of Southern Denmark, Odense Patient Data Explorative Network | Depression, Anxiety | 12/23 | 09/24 | | |
NOBLE-CTO, NCT03392415: The NOrdic-Baltic Randomized Registry Study for Evaluation of PCI in Chronic Total Coronary Occlusion |
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| Recruiting | N/A | 2000 | Europe | CTO PCI | Leif Thuesen | Chronic Total Occlusion of Coronary Artery, Heart Failure, Angina Pectoris | 07/30 | 07/30 | | |
| Andersen, Lars I |
NCT05436054: A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy |
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| Recruiting | 4 | 400 | Europe | Picoprep, Plenvu | Aalborg University Hospital, North Denmark Regional Hospital, Norgine | Colon Disease | 05/24 | 08/24 | | |
| Recruiting | 4 | 778 | Europe | Sodium bicarbonate, Sodium chloride | Lars Wiuff Andersen, University of Aarhus | Cardiac Arrest | 05/25 | 02/26 | | |
COMBAT-ARF, NCT06319274: Infusion of Prostacyclin Vs Placebo for 72-hours in Mechanically Ventilated Patients with Acute Respiratory Failure |
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| Recruiting | 2 | 450 | Europe | Iloprost, Ilomedin, Isotonic saline | Pär Johansson | Acute Respiratory Failure, Endothelial Dysfunction, Pulmonary Infection | 12/26 | 12/26 | | |
| Active, not recruiting | N/A | 115 | Europe | Small intervention, control group, Intervention camp, Behavioral intervention, Camp intervention, Physical activity intervention | University of Southern Denmark, TrygFonden, Denmark | Children, Overweight, Obesity, Metabolic Syndrome | 07/14 | 07/21 | | |
| Recruiting | N/A | 400 | Europe | Physical workload | National Research Centre for the Working Environment, Denmark, University of Southern Denmark | Musculoskeletal Disorders, Stress | 12/22 | 09/23 | | |
| Kold, Søren |
NCT05601765: The Effect of Digital Team-based Communication on Patient-initiated Telephone Contacts to Hospital After Discharge |
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| Completed | N/A | 70 | Europe | Standard communication pathways after discharge, Digital team-based communication after discharge | Aalborg University Hospital, Aalborg University | Orthopaedic Surgery | 06/23 | 07/23 | | |
SENSE, NCT04075461: Arthroplasty Versus Internal Fixation for Undisplaced Femoral Neck Fracture |
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| Active, not recruiting | N/A | 330 | Europe | Arthroplasty, Internal fixation | University of Southern Denmark, Aalborg University Hospital, North Denmark Regional Hospital, Aarhus University Hospital, Odense University Hospital, Slagelse Hospital, Bispebjerg Hospital, Regionshospitalet Viborg, Skive, Randers Regional Hospital, Regionshospitalet Horsens, Hospital of Southern Jutland, Hospital of South West Jutland, Hvidovre University Hospital, Herlev Hospital, Hillerod Hospital, Denmark, Holbaek Sygehus, Zealand University Hospital, Sygehus Lillebaelt, Nykøbing Falster County Hospital, Regional Hospital West Jutland, Bornholm Hospital | Undisplaced Fracture, Femoral Neck Fractures, Internal Fixation; Complications, Arthroplasty Complications | 01/24 | 01/25 | | |
| Nielsen, Poul T |
| Active, not recruiting | N/A | 350 | Europe | Primoris | Zimmer Biomet, Biomet Denmark A/S | Coxarthrosis | 12/22 | 12/24 | | |
ProHipQ-F, NCT05530174: Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With a Fracture |
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| Recruiting | N/A | 2000 | Europe | Antibiotic dosage practice | Soren Overgaard, University of Copenhagen, University Hospital Bispebjerg and Frederiksberg, Odense University Hospital, Aarhus University Hospital, University of Aarhus, Sygehus Lillebaelt | Fracture of Hip, Total Hip Arthroplasty, Prosthetic-joint Infection, Fracture Acetabular | 11/24 | 07/25 | | |
ProHipQ-OA, NCT05530551: Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With OA |
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| Recruiting | N/A | 20000 | Europe | Antibiotic dosage practice | Soren Overgaard, University of Copenhagen, University Hospital Bispebjerg and Frederiksberg, Odense University Hospital, Aarhus University Hospital, University of Aarhus, Sygehus Lillebaelt | Osteoarthritis, Hip, Total Hip Arthroplasty, Prosthetic-joint Infection | 11/24 | 07/25 | | |
| Blicher, Jakob U |
| Completed | N/A | 13 | Europe | tDCS | University of Aarhus, Aarhus University Hospital, Brain+ ApS, Eurostars EUREKA, Innovation Fund Denmark | Genetic Predisposition | 12/22 | 11/23 | | |
| Recruiting | N/A | 180 | Europe | Emotion Discrimination Task (EDT) | University of Aarhus, Aarhus University Hospital, Aalborg University Hospital | Amyotrophic Lateral Sclerosis, Neuromuscular Diseases, ALS, Motor Neuron Disease, MND (Motor Neurone DIsease) | 06/26 | 06/26 | | |
NCT06399978: The Feasibility and Effect of Digital Cognitive Training in Mild Cognitive Impairment |
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| Not yet recruiting | N/A | 40 | Europe | Brain Blossom - Gamified Differential Outcome Training, DOT, Gamified Non-Differential Outcome Training, NDOT | Pernille Louise Kjeldsen, Brain+ ApS, Eurostars EUREKA, Innovation Fund Denmark, University of Aarhus | Mild Cognitive Impairment | 12/24 | 01/25 | | |
| Jensen, Lars T |
NEOLAR, NCT03280407: NEOadjuvant Chemotherapy Only Compared With Standard Treatment for Locally Advanced Rectal Cancer |
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| Recruiting | 2 | 124 | Europe | Capecitabine, FOLFOX regimen (oxaliplatin/leucovorin/5FU), FOLFOX (oxaliplatin/leucovorin/5FU), CAPOX (oxaliplatin/capecitabine) | Zealand University Hospital | Colorectal Neoplasm, Colorectal Cancer, Rectal Neoplasms, Chemotherapy Effect, Intestinal Disease, Intestinal Neoplasms, Rectal Cancer | 12/18 | 12/24 | | |
| Completed | 2 | 70 | Europe | Irinotecan 165 mg/m2 iv, Oxaliplatin 85 mg/m2 iv, Calcium folinate 200 mg/m2 iv, 5-fluorouracil 3200 mg/m2, Tocotrienol, Placebo | Vejle Hospital | Colorectal Cancer | 08/19 | 03/24 | | |
ProTarget, NCT04341181: - A Danish Nationwide Clinical Trial on Targeted Cancer Treatment Based on Genomic Profiling |
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| Recruiting | 2 | 300 | Europe | Alectinib, Alecensa, Atezolizumab, Tecentriq, Avelumab, Bavencio, Axitinib, Inlyta, Erlotinib, Tarceva, Vemurafenib plus Cobimetinib (combination), Zelboraf plus Cotellic (combination), Trastuzumab plus Pertuzumab (combination), Herceptin plus Perjeta (combination), Trastuzumab emtansine, Kadcyla, Vismodegib, Erivedge, Niraparib, Zejula | Ulrik Lassen, Roche Pharma AG, Pfizer, GlaxoSmithKline | Cancer, Tumors, Neoplasms, Neoplasia | 04/24 | 04/25 | | |
WW3, NCT04095299: Standard Dose Versus High Dose of Radiotherapy in Rectal Preservation With Chemo-radiotherapy in Rectal Cancer Patients |
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| Recruiting | 2 | 111 | Europe | 50.4 Gy to the tumor and elective volume, 62 Gy to the clinical tumor volume and 50.4 Gy to the elective volume, Capecitabine 825 mg/m2 twice daily on weekdays | Vejle Hospital | Cancer of Rectum | 12/27 | 12/28 | | |
| Active, not recruiting | N/A | 27 | Europe | 2.15 gray and 1.8 gray. Max. 6 weeks., 2.15 gray and 1.8 gray. Max. 5 weeks. | Vejle Hospital | Anal Cancer | 06/21 | 06/25 | | |
NCT03821870: Predictive Value of Analysing Tissue From Patients With Metastatic Pancreatic Cancer for Drug Sensitivity |
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| Completed | N/A | 12 | Europe | Inditreat, Experimental drug | Vejle Hospital | Metastatic Pancreatic Cancer | 12/21 | 02/23 | | |
NCT04287218: Reducing Fear of Cancer Recurrence in Danish Colorectal Cancer Survivors |
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| Active, not recruiting | N/A | 200 | Europe | TG-iConquerFear, aTAU, Augmented treatment as usual | Vejle Hospital, Aarhus University Hospital, Centre for Oncology Education and Research Translation (CONCERT), Australia, Danish Cancer Society | Fear of Cancer Recurrence, Colorectal Cancer, Anxiety, Health Anxiety, Bodily Distress Syndrome | 07/24 | 09/25 | | |
| Completed | N/A | 218 | Europe | Cardiologic assessment | Vejle Hospital, Region of Southern Denmark | Solid Carcinoma, 5-Fluorouracil Toxicity, Cardiotoxicity, Chemotherapeutic Toxicity, Acute Coronary Syndrome, Coronary Artery Calcification, Chest Pain | 06/24 | 06/24 | | |
| Arendt-Nielsen, Lars - |
| Enrolling by invitation | N/A | 600000 | Europe | Questionnaire and register-based data assessment | Aalborg University | COVID-19, Pain, Chronic | 07/23 | 08/24 | | |
NCT03886259: Effects of Exercise and Education in Patients With Chronic Pain After Total Knee Replacement |
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| Completed | N/A | 71 | Europe | Neuromuscular exercises (NEMEX-TJR) and pain neuroscience education, Pain neuroscience education | Aalborg University, Northern Orthopaedic Division, Denmark, The Danish Rheumatism Association, Svend Andersen Foundation, Lions Denmark | Arthroplasty, Replacement, Knee, Chronic Pain | 02/23 | 04/24 | | |
| Terkelsen, Christian J |
| Recruiting | 3 | 1000 | Europe | Dexamethasone, Dexavit, Backrest elevation, Early wakeup call, Olanzapine | Christian Hassager | Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome | 09/27 | 12/27 | | |
PiCSO-AMI-V, NCT04958421: A Study to Evaluate Safety and Feasibility of PiCSO Therapy in Patients With ST Elevation Inferior Wall Myocardial Infarction. |
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| Terminated | N/A | 25 | Europe | PiCSO Impulse System | Miracor Medical SA | STEMI - ST Elevation Myocardial Infarction, Inferior Wall Myocardial Infarction | 02/23 | 02/23 | | |
| Active, not recruiting | N/A | 1031 | Europe | chosen TAVI valve | Aarhus University Hospital Skejby, Odense University Hospital, Aalborg University Hospital | Transcatheter Aortic Valve Implantation | 11/23 | 11/34 | | |
ACCESS-IV, NCT05365282: Association Between Radial Artery Intervention and Development of Neuropathy in the Hand - A Prospective Study |
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| Recruiting | N/A | 400 | Europe | | Aarhus University Hospital Skejby | Ischemic Heart Disease, Nerve Injury, Carpal Tunnel Syndrome | 03/26 | 12/26 | | |
| Recruiting | N/A | 1006 | Europe | Immediate coronary angiography | Uppsala University | Out-of-Hospital Cardiac Arrest | 06/24 | 12/24 | | |
| Recruiting | N/A | 1200 | Europe | SpinChip hs-cTnI | SpinChip Diagnostics ASA, Scandinavian Contract Research Organization | Acute Myocardial Infarction | 07/25 | 07/25 | | |
| Recruiting | N/A | 1346 | Europe | Medtronic Evolut FX, Edwards Sapien 3 Ultra Resilia | Christian Juhl Terkelsen, Department of Clinical Epidemiology, Aarhus University, DK-8200 Aarhus N, Denmark | Aortic Stenosis | 12/25 | 12/36 | | |
DANSPOT, NCT05336435: A Study of Population and Sex-specific Troponin Cutoffs for Ruling Out Acute Myocardial Infarction |
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| Recruiting | N/A | 7500 | Europe | Implementation of the new population and sex-specific 99th percentile URL for cardiac troponin | Herlev Hospital, Rigshospitalet, Denmark, Nordsjaellands Hospital, Amager Hospital, Bispebjerg Hospital, Zealand University Hospital, Slagelse Sygehus, Nykøbing Falster County Hospital, Holbaek Sygehus, Odense University Hospital, Svendborg Hospital, Kolding Sygehus, Aarhus University Hospital, Gødstrup Hospital, Central Jutland Regional Hospital, Randers Regional Hospital, Glostrup University Hospital, Copenhagen, Hvidovre University Hospital, Vejle Hospital, Hospital of Southern Jutland, Horsens Hospital, Aalborg University Hospital, North Denmark Regional Hospital, Sydvestjysk Sygehus, Herlev and Gentofte Hospital | Coronary Syndrome, Acute, Coronary Artery Disease, Myocardial Infarction | 02/25 | 02/25 | | |
| Recruiting | N/A | 1200 | Europe | Acute CAG | Aarhus University Hospital Skejby, Aalborg University Hospital, Odense University Hospital, Rigshospitalet, Denmark | Cardiac Arrest, Out-Of-Hospital, Angiography, Percutaneous Coronary Intervention, Coma | 05/26 | 05/27 | | |
| Sørensen, Anne Marie |
LD-VenEx, NCT05431257: Azacitidine in Combination With Low Dose Intensity Venetoclax in Patients With AML Incl. Explorative AML Profiling |
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| Recruiting | 2 | 117 | Europe | Venetoclax | Rigshospitalet, Denmark, Helse Stavanger HF, University Hospital of North Norway, Haukeland University Hospital, St. Olavs Hospital, Vestre Viken Hospital Trust, Helse Møre og Romsdal HF, Karolinska University Hospital, Skane University Hospital, Uppsala University Hospital, Helsinki University Central Hospital, Oulu University Hospital, Tampere University Hospital, Kuopio University Hospital | Acute Myeloid Leukemia | 09/31 | 09/31 | | |
HI-MET, NCT04617405: Hormonal and Inflammatory Changes During Pregnancy in Women With Glucose Metabolic Disorders. |
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| Recruiting | N/A | 300 | Europe | No interventions | University of Aarhus, Aarhus University Hospital, Aalborg University Hospital, Odense University Hospital, The University of Queensland | Diabetes Mellitus, Type 2, Gestational Diabetes, Overweight and Obesity, Pregnancy in Diabetic, Insulin Resistance, Insulin Sensitivity, Pregnancy, High Risk | 12/23 | 12/23 | | |
NCT04924504: Mechanisms Behind Severe Insulin Resistance During Pregnancy in Women With Glucose Metabolic Disorders (SIR-MET) |
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| Recruiting | N/A | 24 | Europe | No interventions | University of Aarhus, Aarhus University Hospital, Aalborg University Hospital, The University of Queensland | Diabetes Mellitus, Type 2, Gestational Diabetes, Overweight and Obesity, Pregnancy in Diabetic, Insulin Resistance, Insulin Sensitivity, Pregnancy, High Risk | 12/23 | 12/23 | | |
NCT06471140: Maternal Cardiovascular Adaption to Pregnancy in IVF Patients Following Frozen Embryo Transfer (FET) |
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| Not yet recruiting | N/A | 75 | NA | magnetic resonance imaging (MRI), Elastography, Seismocardiography | Aalborg University Hospital, Regionshospitalet Viborg, Skive | IVF, Frozen Embryo Transfer (FET), Cardiovascular Adaption, Magnetic Resonance Imaging (MRI), Preeclampsia | 08/27 | 08/28 | | |
ProHipQ-F, NCT05530174: Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With a Fracture |
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| Recruiting | N/A | 2000 | Europe | Antibiotic dosage practice | Soren Overgaard, University of Copenhagen, University Hospital Bispebjerg and Frederiksberg, Odense University Hospital, Aarhus University Hospital, University of Aarhus, Sygehus Lillebaelt | Fracture of Hip, Total Hip Arthroplasty, Prosthetic-joint Infection, Fracture Acetabular | 11/24 | 07/25 | | |
ProHipQ-OA, NCT05530551: Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With OA |
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| Recruiting | N/A | 20000 | Europe | Antibiotic dosage practice | Soren Overgaard, University of Copenhagen, University Hospital Bispebjerg and Frederiksberg, Odense University Hospital, Aarhus University Hospital, University of Aarhus, Sygehus Lillebaelt | Osteoarthritis, Hip, Total Hip Arthroplasty, Prosthetic-joint Infection | 11/24 | 07/25 | | |
| Recruiting | N/A | 2500 | Europe | | Odense University Hospital | Pregnancy in Diabetic, Type 1 Diabetes, Type 2 Diabetes, Parents, Fetal Complications, Maternal Diabetes, Birth Injuries, Family | 12/27 | 12/30 | | |
| Thorlacius-Ussing, Ole |
NCT05436054: A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy |
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| Recruiting | 4 | 400 | Europe | Picoprep, Plenvu | Aalborg University Hospital, North Denmark Regional Hospital, Norgine | Colon Disease | 05/24 | 08/24 | | |
CHEMOFIRE-2, NCT04093141: Chemotherapy Followed by Irreversible Electroporation in Patients With Unresectable Locally Advanced Pancreatic Cancer |
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| Recruiting | N/A | 30 | Europe | IRE, irreversible electroporation | Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery | Unresectable Pancreatic Cancer | 05/22 | 05/24 | | |
| Recruiting | N/A | 400 | Europe | Recurrence monitoring with circulating tumor DNA (ctDNA) as a high risk biomarker, Monitoring for late adverse effects with electronic patient reported outcome measures (ePROMs), Systematic treatment of organ-specific late effects and/or biopsychosocial late effects, Digital care-guide for long-term follow-up after cancer treatment | University of Aarhus, Aarhus University Hospital, Aalborg University Hospital, University of Southern Denmark, Randers Regional Hospital, Viborg Regional Hospital, Gødstrup Hospital, Odense University Hospital, Herlev Hospital, Bispebjerg Hospital, Sygehus Lillebaelt, Svendborg Hospital | Colorectal Cancer, Quality of Life, Survivorship | 03/28 | 02/30 | | |
| Recruiting | N/A | 67 | Europe | | University of Aarhus, Copenhagen University Hospital at Herlev, Regional Hospital Horsens, Aarhus University Hospital, Regional Hospital Randers | Colorectal Cancer, Colorectal Polyp, Colorectal Cancer Stage I | 12/24 | 07/27 | | |
NCT06111105: GUIDE.MRD-01-CRC: Clinical Validation and Benchmarking of Top Performing CtDNA Diagnostics - Colorectal Cancer |
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| Recruiting | N/A | 590 | Europe | | Claus Lindbjerg Andersen, Medical University of Graz, University Medical Centre of Montpellier, Universitätsklinikum Hamburg-Eppendorf, University of Aarhus, Karolinska Institutet, Stockholm, Sweden | Colorectal Cancer Stage III, Liver Metastasis Colon Cancer | 07/25 | 07/30 | | |
NCT03637686: IMPROVE: Circulating Tumor DNA Analysis to Optimize Treatment for Patients With Colorectal Cancer |
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| Active, not recruiting | N/A | 3182 | Europe | | University of Aarhus, Aarhus University Hospital | Colorectal Cancer | 07/28 | 07/28 | | |
| Recruiting | N/A | 1600 | Europe | | University of Aarhus, Aarhus University Hospital | Colorectal Neoplasms, Colorectal Cancer, Colorectal Adenocarcinoma, Colorectal Cancer Stage I, Colorectal Cancer Stage II, Colorectal Cancer Stage III | 07/28 | 07/30 | | |
| Christiansen, Ole B |
| Recruiting | 2 | 74 | Europe | Human Intravenous Immunoglobulins, (Privigen (R), CLS Behring), IVIg, Prednisolone Tablets, Human Albumin Solution, Albumin infusion, Placebo tablet | Aalborg University Hospital, Clinical Immunological Department, Aalborg University Hospital, Svend Andersen Fonden, The Pharmacy of Aalborg University Hospital, GCP department of Aalborg University Hospital, Beckett Foundation, L.F. Foghts Foundation | Habitual Abortion, Recurrent Pregnancy Loss, Fertility Disorders, Miscarriage | 06/23 | 08/23 | | |
| Nielsen-Kudsk, Jens Erik |
| Active, not recruiting | N/A | 45 | Europe | Left atrial appendage closure device WM FLX Pro | Boston Scientific Corporation | Non-valvular Atrial Fibrillation (AF) | 10/24 | 11/25 | | |
NCT03642509: Left Atrial Appendage Occlusion Versus Novel Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation |
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| Recruiting | N/A | 750 | Europe | Left atrial appendage occlusion, Left atrial appendage closure, NOAC, Edoxaban, Apixaban, Rivaroxaban, Dabigatran | University of Aarhus, Aarhus University Hospital, Aalborg University Hospital, Odense University Hospital, Sahlgrenska University Hospital, Sweden, Karolinska University Hospital, Haukeland University Hospital, Helsinki University Central Hospital, Gødstrup Hospital, Lund University Hospital, Oslo University Hospital, Trondheim University Hospital, Rigshospitalet, Denmark, Jena University Hospital | Atrial Fibrillation, Stroke | 01/26 | 10/30 | | |
NCT05324371: A Pilot Study to Assess WATCHMAN FLX™ Implants by Cardiac Computed Tomography, Magnetic Resonance Imaging and Transesophageal Echocardiography: WATCHMAN FLX™ CT |
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| Active, not recruiting | N/A | 25 | Europe | Watchman FLX Device | Boston Scientific Corporation | The Focus of the Study is to Reduce the Risk of Stroke and Life-threatening Bleeding Events in Patients With Non-valvular Atrial Fibrillation | 05/24 | 07/25 | | |
NCT06580275: The GLACE Study: Evaluating CLAAS With ICE Guided LAA Closure |
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| Recruiting | N/A | 80 | Europe | CLAAS | Conformal Medical, Inc | Atrial Fibrillation, Stroke Prevention | 06/25 | 12/25 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion |
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| Recruiting | N/A | 450 | Europe, Canada, US | Investigational PFO Closure Device, Standard of Care PFO Closure Device | Occlutech International AB | Stroke, Patent Foramen Ovale, PFO | 10/25 | 10/26 | | |
| Drewes, Asbjørn M |
| Completed | 2/3 | 105 | Europe | Placebo treatment, Methylnaltrexone treatment | Asbjørn Mohr Drewes, Odense University Hospital, Hvidovre University Hospital, University Hospital Bispebjerg and Frederiksberg | Acute Pancreatitis | 04/23 | 04/23 | | |
| Active, not recruiting | 2/3 | 74 | Europe | Placebo treatment, Naldemedine 0.2 MG Oral Tablet | Asbjørn Mohr Drewes, Odense University Hospital, Hvidovre University Hospital, University Hospital Bispebjerg and Frederiksberg, Karolinska University Hospital | Pancreatitis, Acute | 03/24 | 06/24 | | |
NCT05690321: Opium Tincture Against Chronic Diarrhea - Patients |
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| Completed | 2 | 11 | Europe | Opium tincture, Dropizol, Placebo | Asbjørn Mohr Drewes, Aarhus University Hospital | Chronic Diarrhea | 12/23 | 12/23 | | |
NCT06334198: The Effect of Naldemedine on Opioid-induced Bowel Dysfunction |
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| Recruiting | 2 | 20 | Europe | Naldemedine, Placebo, Tramadol | Asbjørn Mohr Drewes | Opioid-Induced Bowel Dysfunction, Constipation | 03/25 | 03/25 | | |
DAN-VNS, NCT04143269: Treatment of Complications to Diabetic Autonomic Neuropathy With Vagus Nerve Stimulation |
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| Completed | N/A | 120 | Europe | Non-invasive transcutaneous vagus nerve stimulation, GammaCore device, Sham vagus nerve stimulation, GammaCore sham device | Aalborg University Hospital, ElectroCore INC | Gastrointestinal Dysfunction, Diabetes Mellitus | 02/23 | 02/23 | | |
NCT06152887: Noninvasive Cortical Neurostimulation For Diabetic Neuropathic Pain |
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| Recruiting | N/A | 40 | Europe | Sooma Oy (tDCS), Helsinki, Finland, Sooma Oy (Sham), Helsinki, Finland | Jens Brøndum Frøkjær, Novo Nordisk A/S, Vissing fonden | Diabetic Neuropathy, Painful, Diabetes Mellitus, Type 1 | 12/24 | 12/25 | | |
| Strandhave, Charlotte |
| Recruiting | 4 | 48 | Europe | Teriparatide, Terrosa, DXA,VFA, X-ray, HR-pQCT, 18-F NAF PET/CT, Bone biopsy, Cardiac tests, Blood and urine samples and physical examination | Ditte Hansen, Odense University Hospital, Steno Diabetes Center Copenhagen, Rigshospitalet, Denmark, Aalborg University Hospital | Adynamic Bone Disease, Chronic Kidney Diseases, Cardiac Disease, Chronic Kidney Disease-Mineral and Bone Disorder | 09/26 | 09/27 | | |
| Recruiting | N/A | 300 | Europe | Kidney Biopsy | Herlev Hospital, Rigshospitalet, Denmark, Hillerod Hospital, Denmark, Zealand University Hospital, Holbaek Sygehus, Slagelse Sygehus, Nykøbing Falster County Hospital, Aarhus University Hospital, The Novo Nordisk Foundation Center for Basic Metabolic Research, Novo Nordisk A/S, Gubra ApS, Odense University Hospital, Aalborg University Hospital, Gødstrup Hospital, Steno Diabetes Center Copenhagen, Steno Diabetes Center Sjaelland, Steno Diabetes Center Nordjylland, Michigan Kidney Translational Medical Center | Chronic Kidney Diseases, Albuminuria, Diabetic Kidney Disease, Diabetic Nephropathies, Diabetes type2, Molecular Sequence Variation, Kidney Biopsy | 12/43 | 12/43 | | |
| Spindler, Karen-Lise G |
| Completed | 2 | 16 | Europe | Hyperfractionated external beam radiation | Aarhus University Hospital, Oslo University Hospital | Rectal Cancer, Recurrence, Radiation Toxicity | 01/19 | 01/23 | | |
IMPROVE-IT, NCT03748680: IMPROVE Intervention Trial Implementing Non-invasive Circulating Tumor DNA Analysis to Optimize the Operative and Postoperative Treatment for Patients With Colorectal Cancer |
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| Recruiting | 2 | 64 | Europe | Capox (or FOLFOX) including flouropyrimidine and oxaliplatin combination chemotherapy, Intensified Follow-up Schedule | Karen-Lise Garm Spindler | Colorectal Cancer, Circulating Tumor DNA, Adjuvant Chemotherapy, Progression Free Survival | 10/23 | 10/25 | | |
| Not yet recruiting | 2 | 167 | Europe | Standard of care, ctDNA-RECIST guided palliative systemic treatment | Karen-Lise Garm Spindler, Vejle Hospital | Gastrointestinal Neoplasm | 09/29 | 09/30 | | |
| Recruiting | 2 | 350 | Europe | Standard of care, Circulating tumor DNA guided treatment approach | Karen-Lise Garm Spindler, Vejle Hospital, Zealand University Hospital | Colorectal Cancer, Metastatic Cancer | 03/27 | 03/30 | | |
| Active, not recruiting | N/A | 100 | Europe | Bone sparring radiotherapy | Karen-Lise Garm Spindler, Herlev Hospital, Zealand University Hospital, Vejle Hospital | Anal Cancer, Radiotherapy Side Effect | 01/25 | 03/26 | | |
NCT05572801: NOAC9 - Circulating Tumor DNA Guided Follow-Up in Anal Cancer |
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| Recruiting | N/A | 400 | Europe | AMR B: HPV positive ctDNA guided imaging in follow-up | Aarhus University Hospital, Danish Comprehensive Cancer Center, Nordic Cancer Union, The regions medicine- and treatment funds | Anal Cancer | 06/26 | 06/31 | | |
NCT03637686: IMPROVE: Circulating Tumor DNA Analysis to Optimize Treatment for Patients With Colorectal Cancer |
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| Active, not recruiting | N/A | 3182 | Europe | | University of Aarhus, Aarhus University Hospital | Colorectal Cancer | 07/28 | 07/28 | | |
| Nielsen, René |
DUAG9, NCT05913947: Lithium Versus Cariprazine in the Acute Phase Treatment of Bipolar Depression |
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| Recruiting | 4 | 122 | Europe | Lithium, Litarex, ATC; N05AN01, Cariprazine, Reagila, ATC: N05AX15 | Aalborg University Hospital, Mental Health Center, Glostrup, Mental Health Center North Zealand, Mental Health Department Odense, University Clinic, Psychiatric Center Copenhagen, Rigshospitalet | Depression, Bipolar | 09/24 | 09/24 | | |
| Recruiting | N/A | 600 | Europe | Antipsychotic | Herlev and Gentofte Hospital, Rigshospitalet, Denmark, Bispebjerg Hospital, Nordsjaellands Hospital, University Hospital, Gentofte, Copenhagen, Zealand University Hospital, Odense University Hospital, Aarhus University Hospital, Aalborg University Hospital | Death, Sudden, Cardiac, Arrythmia, Antipsychotics and Neuroleptics Toxicity | 12/22 | 12/24 | | |
| Stenbygaard, Lars |
NCT00909818: Hypofractionated Versus Standard Fractionated Whole Breast Irradiation to Node-negative Breast Cancer Patients |
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| Active, not recruiting | 3 | 976 | Europe | standard fractionated radiotherapy, hypofractionated radiotherapy | Danish Breast Cancer Cooperative Group, Danish Cancer Society | Breast Cancer, Carcinoma in Situ of the Breast | 05/24 | 05/24 | | |
NCT04291378: The DBCG Proton Trial: Photon Versus Proton Radiation Therapy for Early Breast Cancer |
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| Recruiting | 3 | 1502 | Europe | Proton versus photon radiation therapy | Danish Breast Cancer Cooperative Group | Early Breast Cancer, Radiation Associated Cardiac Failure | 06/27 | 06/37 | | |
NCT00892814: Partial Breast Versus Whole Breast Irradiation in Elderly Women Operated on for Early Breast Cancer |
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| Active, not recruiting | N/A | 882 | Europe | Partial breast irradiation, Whole breast irradiation | Danish Breast Cancer Cooperative Group, Danish Center for Interventional Research in Radiation Oncology (CIRRO), Danish Cancer Society | Breast Carcinoma | 03/16 | 03/26 | | |
NCT02384733: Hypofractionated Loco-regional Adjuvant Radiation Therapy of Breast Cancer Combined With a Simultaneous Integrated Boost |
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| Active, not recruiting | N/A | 2963 | Europe | Loco-regional RT | Danish Breast Cancer Cooperative Group, Danish Cancer Society | Lymphedema, Fibrosis | 07/21 | 07/32 | | |
