VÅ¡eobecnÃ¡ fakultnÃ nemocnice v Praze Trials

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Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

Jayne, David

HAVEN, NCT04316494: Hydroxychloroquine in ANCA Vasculitis Evaluation

Active, not recruiting

Europe

Hydroxychloroquine, Plaquenil, Placebo, Control

Guy's and St Thomas' NHS Foundation Trust, Medical Research Council

ANCA Associated Vasculitis, Microscopic Polyangiitis, Churg-Strauss Syndrome, Wegener Granulomatosis

05/25

OCEAN, NCT05263934 / 2021-005726-15: Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)

Recruiting

160

Europe, Canada, Japan, US, RoW

Depemokimab, Mepolizumab, Placebo matching mepolizumab, Placebo matching depemokimab

GlaxoSmithKline

Eosinophilic Granulomatosis With Polyangiitis

10/25

11/25

BIOVAS, NCT05168475 / 2019-003964-30: Biologics in Refractory Vasculitis

Active, not recruiting

Europe

Rituximab, Infliximab, Tocilizumab

Cambridge University Hospitals NHS Foundation Trust

Giant Cell Arteritis, Takayasu Arteritis, Cogan Syndrome, Relapsing Polychondritis, Cryoglobulinemic Vasculitis, IgA Vasculitis, Polyarteritis Nodosa, Cutaneous Polyarteritis Nodosa, Primary Angiitis of Central Nervous System

11/23

06/24

NCT03416023: Safety, Performance and Durability of the TIES® Implant in Patients Requiring a Permanent Ileostomy

Terminated

N/A

Europe

TIES® (Transcutaneous Implant Evacuation System)

Ostomycure AB, Veranex

Ileostomy - Stoma

11/23

MASTERY, NCT04647188: Measuring the Quality of Surgical Care and Setting Benchmarks for Training Using Intuitive Data Recorder Technology

Active, not recruiting

N/A

500

Europe

Robotic assisted surgery with IDR data capture

University of Birmingham, Newcastle-upon-Tyne Hospitals NHS Trust, Imperial College Healthcare NHS Trust, Barts & The London NHS Trust, Portsmouth Hospitals NHS Trust, Royal Marsden NHS Foundation Trust, Wirral University Teaching Hospital NHS Trust, The Leeds Teaching Hospitals NHS Trust, Guy's and St Thomas' NHS Foundation Trust, South Tees Hospitals NHS Foundation Trust, University Hospitals Coventry and Warwickshire NHS Trust, Intuitive Surgical, University Hospitals, Leicester, Sheffield Teaching Hospitals NHS Foundation Trust, Golden Jubilee National Hospital, Royal Surrey County Hospital NHS Foundation Trust, Oxford University Hospitals NHS Trust, The Christie NHS Foundation Trust

Cancer, Surgery

06/23

10/23

Cibula, David

innovaTV 301, NCT04697628 / 2019-001655-39: Tisotumab Vedotin vs Chemotherapy in Recurrent or Metastatic Cervical Cancer

Active, not recruiting

502

Europe, Canada, Japan, US, RoW

tisotumab vedotin, TIVDAK, topotecan, vinorelbine, gemcitabine, irinotecan, pemetrexed

Seagen Inc., Genmab

Cervical Cancer

07/23

08/25

PORTEC-4a, NCT03469674: Molecular Profile-based Versus Standard Adjuvant Radiotherapy in Endometrial Cancer

Active, not recruiting

550

Europe, RoW

Vaginal brachytherapy, External beam radiotherapy, Observation

Leiden University Medical Center, Dutch Cancer Society, Comprehensive Cancer Centre The Netherlands

Endometrial Cancer Stage I, Endometrial Cancer Stage II

12/24

12/28

ENGOT-EN20, NCT05611931 / 2022-002540-42: Selinexor in Maintenance Therapy After Systemic Therapy for Participants with P53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma

Jul 2024 - Dec 2024: Top-line data from XPORT-EC trial in participants with TP53 wild type endometrial cancer

Recruiting

220

Europe, Canada, US, RoW

Selinexor, KPT-330, Matching Placebo for selinexor

Karyopharm Therapeutics Inc, GOG Foundation, European Network of Gynaecological Oncological Trial Groups (ENGOT), Belgium and Luxembourg Gynaecological Oncology Group, North Eastern German Society of Gynaecological Oncology, Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies, Spanish Research Group in Ovarian Cancer, The Central and Eastern European Gynecologic Oncology Group, Israeli Society of Gynecologic Oncology, Australia New Zealand Gynaecological Oncology Group

Endometrial Cancer

01/25

01/28

PHOCUS, NCT04789694: Prehabilitation in Gynaecological Cancer Patients

Recruiting

RoW

Physiological intervention, Psychological intervention, Nutritional intervention

Charles University, Czech Republic, University Hospital Ostrava, University Hospital Olomouc, University Hospital Pilsen, The Faculty Hospital Na Bulovce

Ovarian Cancer, Ovarian Cancer Stage III, Ovarian Cancer Stage IV, Endometrial Cancer, Frailty

06/25

06/26

FLORA-4, NCT04498117 / 2020-002270-26: Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery

Active, not recruiting

615

Europe, Canada, US, RoW

Oregovomab, MAb-B43.13, Paclitaxel, Taxol, Carboplatin, Paraplatin, Placebo

CanariaBio Inc., Gynecologic Oncology Group, Iqvia Pty Ltd

Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma, Fallopian Tube Neoplasms, Fallopian Tube Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Peritoneal Cancer, Peritoneal Carcinoma, Peritoneal Neoplasms

09/25

08/27

CERVANTES, NCT04989647: Intermediate Risk Cervical Cancer: Radical Surgery +/- Adjuvant Radiotherapy

Recruiting

514

RoW

No adjuvant therapy, Adjuvant radiotherapy

The Central and Eastern European Gynecologic Oncology Group

Cervical Cancer

12/29

12/32

SENTIX, NCT02494063: Sentinel Lymph Node Biopsy in Patients With Early Stages Cervical Cancer

Completed

N/A

600

RoW

Sentinel lymph node biopsy, At least unilateral systematic pelvic lymph node dissection

Charles University, Czech Republic

Cervical Cancer

12/22

02/24

TESLA-1, NCT04665544: Tracers for Endometrial Cancer Sentinel Node Labeling

Recruiting

N/A

Europe, RoW

SLN side-specific detection rate using radioactive tracer with/without blue dye and ICG tracer.

University Medical Centre Maribor

Endometrial Cancer, Sentinel Lymph Node

01/23

01/24

SENTICOL III, NCT03386734: International Validation Study of Sentinel Node Biopsy in Early Cervical Cancer

Active, not recruiting

N/A

989

Europe, Canada, Japan, RoW

SLN biopsy only, SLN biopsy + PLN dissection

Centre Hospitalier Universitaire de Besancon, ARCAGY/ GINECO GROUP, European Network of Gynaecological Oncological Trial Groups (ENGOT)

Cervical Cancer

05/27

05/29



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