| Investigator, Principal |
NCT05120895: An Observational Study Investigating the Change in Blood Cholesterol With Mevalotin® Tablet Administration in Korean Menopausal Women Aged 50 Years or More Who Require Treatment of Dyslipidemia |
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| Active, not recruiting | N/A | 3300 | RoW | Mevalotin | Daiichi Sankyo, Daiichi Sankyo Korea Co., Ltd. | Dyslipidemia | 04/25 | 04/25 | | |
NCT05606094: Real-World Observational Study to Describe Treatment Patterns in Patients With HER2-Positive Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer in East Asia |
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| Completed | N/A | 450 | RoW | | Daiichi Sankyo Co., Ltd. | Gastric Cancer | 11/23 | 11/23 | | |
NCT03866707: Epigenetic and Metabolomic Changes in Childhood Cancer Survivors |
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| Terminated | N/A | 7 | US | One-time blood draw, Evaluation of CpG methylation, Metabolomic analysis | Wake Forest University Health Sciences | Childhood Cancer | 05/20 | 05/20 | | |
| Completed | N/A | 11 | US | Psychosocial intervention | Medical University of South Carolina | Aphasia, Stroke | 12/23 | 12/23 | | |
NCT06210776: A Study to Assess the Effectiveness of Trastuzumab Deruxtecan in Chinese Breast Cancer Patients (REFRESH) |
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| Recruiting | N/A | 800 | RoW | Trastuzumab deruxtecan, T-DXd | Daiichi Sankyo | HER2-positive Breast Cancer, HER2-low Breast Cancer, Breast Cancer, Advanced Cancer | 03/28 | 03/28 | | |
NCT04910048: Impact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJA |
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| Active, not recruiting | N/A | 46 | US | POPOP (preoperative patient optimization program), 20Lighter, SOC (standard of care) | University of Arkansas | Osteoarthritis, Knee, Osteoarthritis, Hip, Avascular Necrosis, Rheumatoid Arthritis | 04/23 | 12/24 | | |
NCT06204900: A Post-marketing Study to Evaluate a Novel Surgical Monitoring Technique Using the EARP Nerve Cuff in TLIF Surgery. |
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| Not yet recruiting | N/A | 30 | US | Nerve Cuff and Retractor System | Retropsoas Technologies, LLC | Undergoing a Single-level or Two-level TLIF Surgery | 06/24 | 08/24 | | |
ACAB, NCT04292405: Accuracy of Cardiac Acoustic Biomarkers Recorded by the Wearable Cardioverter Defibrillator |
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| Recruiting | N/A | 60 | US | Wearable Cardioverter Defibrillator, AUDICOR AM | Zoll Medical Corporation | Heart Failure | 03/24 | 05/24 | | |
| Recruiting | N/A | 60 | US | BHmApp | William Beaumont Hospitals, University of Pennsylvania | Urinary Incontinence | 08/24 | 08/24 | | |
| Recruiting | N/A | 200 | Europe | | Chelsea and Westminster NHS Foundation Trust, ViiV Healthcare | HIV Infections, Gender Identity, Human Immunodeficiency Virus | 04/24 | 10/25 | | |
| Active, not recruiting | N/A | 70 | US | PQ Bypass System | Endologix | Peripheral Artery Diseases | 06/24 | 06/24 | | |
NCT03586414: MitoQ Supplementation and Cardiovascular Function in Healthy Men and Women |
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| Active, not recruiting | N/A | 31 | US | MITOQUINOL MESYLATE then placebo, MitoQ, Mitoquinol methanesulfonate, Placebo, then MITOQUINOL MESYLATE | University of Colorado, Denver, University of Colorado Nutrition Obesity Research Center (NORC) | Diastolic Dysfunction | 07/25 | 08/25 | | |
NCT06361797: Varying Bone Marrow-Derived Mesenchymal Stem Cells Concentrations' Impact on Rotator Cuff Repair Outcomes |
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| Not yet recruiting | N/A | 150 | US | Rotator cuff repair augmented with whole bone marrow, Whole bone marrow, Bone marrow aspirate, Rotator cuff repair augmented with concentrated bone marrow, Bone marrow-derived mesenchymal stem cells, Bone marrow concentrate | Johns Hopkins University, ON Foundation | Rotator Cuff Tears | 07/26 | 12/27 | | |
NCT06340503: Evaluating a Physical Activity Index for Assessment and Counseling for Breast and Colon Cancer Survivors |
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| Recruiting | N/A | 20 | US | Research-grade accelerometer, National Comprehensive Cancer Network (NCCN) Education Materials, Garmin Vivofit activity tracker, Exercise Consultation Calls, Interview, Physical Activity Index Assessment (Intervention Arm), Physical Activity Index Assessment (Control Arm), Health Surveys | Wake Forest University Health Sciences, National Cancer Institute (NCI) | Breast Cancer, Colon Cancer | 07/25 | 08/25 | | |
NCT02945085: 3D Team Care for Cognitively Vulnerable Older Adults |
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| Recruiting | N/A | 576 | US | Home Based Care Team, Telephone Based Care Team | UConn Health, Patient-Centered Outcomes Research Institute, University of Connecticut | Dementia, Depression, Delirium | 07/24 | 07/24 | | |
NCT04931251: Addressing Cancer-Related Financial Toxicity in Rural Oncology Care Settings |
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| Recruiting | N/A | 780 | US | Financial Navigation | UNC Lineberger Comprehensive Cancer Center, National Cancer Institute (NCI) | Neoplasms, Carcinoma | 07/24 | 07/24 | | |
| Active, not recruiting | N/A | 80 | US | Gaming in a virtual environment | Yale University, National Heart, Lung, and Blood Institute (NHLBI) | Cardiovascular Diseases | 07/25 | 07/25 | | |
NCT04927052: A Study to Evaluate the Safety and Efficacy of Revanesse Shape + With Lidocaine Versus Juvederm Voluma With Lidocaine for the Correction of Age-Related Midface Volume Deficit / Lipoatrophy at 6 and 12 Months Post-treatment |
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| Completed | N/A | 136 | Canada | Revanesse Shape + with Lidocaine, Juvederm Voluma with Lidocaine. | Prollenium Medical Technologies Inc. | Volume Deficit in the Mid-face | 08/23 | 08/23 | | |
| Not yet recruiting | N/A | 16 | US | KeraStat cream, M-PART Assessments via MyCap, Clinical Assessments, Feedback phone interview | Wake Forest University Health Sciences, National Cancer Institute (NCI) | Radiation Dermatitis | 08/26 | 08/26 | | |
| Active, not recruiting | N/A | 5000 | RoW | Edoxaban | Daiichi Sankyo, Inc., Daiichi Sankyo (China) Holdings Co., Ltd. | Non-valvular Atrial Fibrillation | 10/24 | 10/24 | | |
ROCK-RT, NCT05169177: Radio-opaque Contrast Agents for Liver Cancer Targeting With KIM During Radiation Therapy |
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| Recruiting | N/A | 50 | RoW | | University of Sydney, Calvary Mater Newcastle, Australia, Western Sydney Local Health District, Austin Health, Peter MacCallum Cancer Centre, Australia, Princess Alexandra Hospital, Brisbane, Australia | Liver Neoplasm | 10/24 | 10/26 | | |
NCT01336790: International Lymphatic Disease and Lymphedema Registry |
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| Recruiting | N/A | 5000 | US | | Stanford University, Lymphatic Education & Research Network | Lymphedema | 12/24 | 12/25 | | |
NCT05531357: Physiologic Mechanisms Underlying Ovarian Follicular Waves During the Menstrual Cycle |
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| Completed | N/A | 50 | Canada | Transvaginal ultrasound scans, Finger-prick blood sampling for dried blood spots, Urine sampling, Venipunctures | University of Saskatchewan, Ansh Labs | Reproductive Issues | 03/24 | 03/24 | | |
| Recruiting | N/A | 200 | US | Education and counseling, Education | Georgetown University | Breast Cancer | 12/24 | 12/25 | | |
NCT05689190: Non-invasive Flow Measurements in Patients With Lower Extremity Arterial Disease (LEAD) |
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| Recruiting | N/A | 30 | Europe | | Philips Clinical & Medical Affairs Global, Leiden University Medical Center | Lower Extremity Arterial Disease | 12/24 | 12/24 | | |
NCT05862467: A Pilot Participatory Program Evaluation of a Virtual Trauma Support Program for Autistic Adults |
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| Recruiting | N/A | 30 | US | Written Exposure Therapy (WET) via telehealth | University of Wyoming | Autism, Trauma, Posttraumatic Stress Disorder, Posttraumatic Stress Symptom | 05/25 | 05/25 | | |
NCT04635111: A Long-term Study Evaluating Hepatotoxicity Associated With TURALIO™ (Pexidartinib) Treatment |
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| Recruiting | N/A | 30 | US | TURALIO™ | Daiichi Sankyo, Inc. | Hepatotoxicity, Tenosynovial Giant Cell Tumor | 06/25 | 03/36 | | |
| Recruiting | N/A | 198 | US | Dietary Intervention Classes | University of South Carolina | Diabetes Mellitus, Type 2, Obesity | 12/25 | 03/26 | | |
MILOS, NCT04579367: Treatment With Bempedoic Acid and/or Its Fixed-dose Combination With Ezetimibe in Primary Hypercholesterolemia or Mixed Dyslipidemia |
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| Recruiting | N/A | 5000 | Europe | Bempedoic acid and/or its fixed-dose combination with ezetimibe | Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company | Hypercholesterolemia, Mixed Dyslipidemia | 09/25 | 09/25 | | |
NCT06054412: An Adjunctive Neurofeedback Training Program to Enhance Wellness Among Trauma-Exposed Postpartum Mothers |
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| Recruiting | N/A | 20 | US | Neuroptimal (Zengar, Inc.) Neurofeedback | Wayne State University | Well-Being, Psychological, Dissociation, Maternal Care Patterns, Maternal Behavior, Maternal Distress, Mood Disturbance, Emotional Regulation, Post Traumatic Stress Disorder | 09/25 | 03/26 | | |
| Active, not recruiting | N/A | 7 | US | Actual device PFO closure, GORE® CARDIOFORM Septal Occluder, Thienopyridine (clopidogrel or prasugrel), Plavix, Effient, Sham device PFO closure | W.L.Gore & Associates | Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale | 12/25 | 08/26 | | |
SILVERCARE_AF, NCT05804747: A Study to Evaluate Effectiveness and Safety of Edoxaban in Patients 80 Years of Age or Older With Nonvalvular Atrial Fibrillation |
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| Recruiting | N/A | 1100 | RoW | Edoxaban | Daiichi Sankyo, Daiichi Sankyo Korea Co., Ltd. | Atrial Fibrillation | 12/25 | 12/25 | | |
LEARN, NCT05184790: Learning Environment for Artificial Intelligence in Radiotherapy New Technology |
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| Not yet recruiting | N/A | 300 | RoW | | University of Sydney, Princess Alexandra Hospital, Brisbane, Australia, Calvary Mater Newcastle, Australia, Western Sydney Local Health District, Austin Health, Peter MacCallum Cancer Centre, Australia | Arrhythmias, Cardiac, Breast Cancer, Prostatic Cancer, Brain Cancer, Kidney Cancer, Head and Neck Cancer, Liver Cancer, Pancreatic Cancer, Spinal Neoplasm | 01/26 | 01/26 | | |
NCT05022862: Economic Incentives and vDOT for Latent Tuberculosis Infection |
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| Recruiting | N/A | 399 | US | Usual Care, Video Directly Observed Therapy alone, Video Directly Observed Therapy plus Financial Incentives | Johns Hopkins University, National Institute of Allergy and Infectious Diseases (NIAID) | Latent Tuberculosis | 04/26 | 10/26 | | |
NCT05993234: A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies (PROSPERITY) |
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| Recruiting | N/A | 257 | Europe | Trastuzumab deruxtecan, T-DXd, ENHERTU® | Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company | HER2-positive Advanced Gastric Cancer, HER2-positive Gastroesophageal Junction Adenocarcinoma | 12/26 | 09/27 | | |
| Recruiting | N/A | 1350 | Europe | Trastuzumab deruxtecan, T-DXd | Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company | Unresectable Breast Cancer, Metastatic Breast Cancer, HER2-low Expressing Breast Cancer | 06/27 | 09/28 | | |
NCT05636397: Safety and PK-PD Study of Oral L-CIT in Preterm Infants With BPD±PH and NEC |
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| Recruiting | N/A | 60 | Canada | L-Citrulline | The Hospital for Sick Children | BPD - Bronchopulmonary Dysplasia, Pulmonary Hypertension, NEC | 12/27 | 03/28 | | |
NCT05181163: Biofilm Formation and Antibiotic Sensitivity Patterns |
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| Not yet recruiting | N/A | 100 | NA | swab | Sohag University | Orthopedic Surgery | 07/22 | 01/23 | | |
| Delsing, Corine |
| Recruiting | N/A | 200 | Europe | HCV RNA self-test | Erasmus Medical Center | Hepatitis C Recurrent, HIV-1-infection | 02/23 | 06/23 | | |
| Opstal, Jurren van |
| Recruiting | N/A | 470 | Europe, RoW | Left ventricular septal pacing, Right ventricular pacing | Maastricht University, ZonMw: The Netherlands Organisation for Health Research and Development, Medtronic | Cardiac Pacing, Pacing-Induced Cardiomyopathy, Conduction System Pacing, Left Ventricular Septal Pacing, Atrioventricular Block | 05/25 | 05/25 | | |
| Masclee, AAM |
NCT04104360: Galacto-oligosaccharides and Intestinal Activity |
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| Recruiting | N/A | 14 | Europe | Galacto-oligosaccharides, Maltodextrin | Maastricht University Medical Center | Healthy Adults | 12/24 | 12/24 | | |
| Recruiting | N/A | 16 | Europe | transcutaneous vagal nerve stimulation (tVNS) | Maastricht University Medical Center, Wingate Institute of Neurogastroenterology | fMRI, Transcutaneous Vagal Nerve Stimulation (tVNS), Nucleus of the Solitary Tract (NTS) | 06/21 | 06/21 | | |
| Willigendael, Edith |
| Recruiting | N/A | 195 | Europe | Arteriovenous fistula creation, Arteriovenous graft placement, Central venous catheter placement | Maastricht University Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development | Vascular Access Complication, Hemodialysis Access Failure, Dialysis Access Malfunction, Arteriovenous Fistula, Arteriovenous Graft, Central Venous Catheter Related Bloodstream Infection | 05/25 | 05/25 | | |
| Preusser, Matthias |
LEGATO, NCT05904119: Lomustine With and Without Reirradiation for First Progression of Glioblastoma: a Randomized Phase III Study |
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| Recruiting | 3 | 411 | Europe | Lomustine, Reirradiation | European Organisation for Research and Treatment of Cancer - EORTC | First Progression of Glioblastoma | 09/27 | 02/28 | | |
TUXEDO-3, NCT05865990: HER3-DXd in Breast Cancer and NSCLC Brain Metastases and Solid Tumor Leptomeningeal Disease |
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| Recruiting | 2 | 60 | Europe | Patritumab deruxtecan, HER3-DXd | MedSIR, Daiichi Sankyo | Metastatic Breast Cancer, Advanced Non-Small Cell Squamous Lung Cancer, Solid Tumor, Adult | 12/25 | 10/26 | | |
REPOSE, NCT06315010: REPotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain mEtastasis |
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| Not yet recruiting | 2 | 20 | NA | Repotrectinib, BMS-986472, TPX-0005 | MedSIR, Medical University of Vienna | NSCLC, Brain Metastases, ROS1 Gene Rearrangement | 03/27 | 04/28 | | |
| Recruiting | 2 | 27 | Europe | Trastuzumab-Deruxtecan (T-DXd), DS-8021a, ENHERTU | MedSIR, Daiichi Sankyo | Breast Cancer, Metastatic Breast Cancer | 09/25 | 07/26 | | |
| Recruiting | N/A | 4975 | Europe, RoW | RP-1828 IMMUcan, RP-1759 AYA/TYA, RP-1843 Arcagen, RP-1920 BioRadon | European Organisation for Research and Treatment of Cancer - EORTC | All Tumor Types | 03/26 | 03/26 | | |
| Holzik, Martijn Lutke |
A1Check, NCT05810207: the External Validation of a Machine Learning Model Predicting Colorectal Anastomotic Leakage |
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| Recruiting | N/A | 1000 | Europe | Colorectal resection | Freek Daams, SAS Institute | Anastomotic Leak, Anastomotic Leak Large Intestine, Anastomotic Complication, Anastomotic Leak Rectum | 07/24 | 12/24 | | |
| Stevenhagen, Jeroen |
| Active, not recruiting | N/A | 609 | Europe | Left atrial appendage occlusion (Watchman FLX or Amplatzer Amulet), Watchman FLX device, Amplatzer Amulet device | R&D Cardiologie, ZonMw: The Netherlands Organisation for Health Research and Development | Atrial Fibrillation, Anticoagulants and Bleeding Disorders | 05/26 | 11/26 | | |
| Vulev, Ivan |
| Recruiting | 4 | 550 | Europe, RoW | Cangrelor, intravenous P2Y12 inhibitor, Ticagrelor, oral P2Y12 inhibitor | Faculty Hospital Kralovske Vinohrady, Charles University, Czech Republic | Acute Myocardial Infarction, Cardiogenic Shock | 01/24 | 01/25 | | |
| Recruiting | N/A | 150 | Europe, RoW | Endurant Chimney Graft Technique | Medtronic Cardiovascular | AAA - Abdominal Aortic Aneurysm | 03/26 | 07/30 | | |
| Jansen, J |
| Active, not recruiting | 4 | 302 | Europe | Augmentin + Gentamicin, Amoxicillin/clavulanic acid (Augmentin) + Gentamicin, Appendectomy | Ramon Gorter, ZonMw: The Netherlands Organisation for Health Research and Development, Amsterdam UMC, location VUmc | Appendicitis | 12/24 | 12/24 | | |
| Recruiting | N/A | 50000 | Europe | | Dutch Colorectal Cancer Group | Colorectal Cancer | 01/50 | 01/51 | | |
| Rinket, Martin |
DIPIC, NCT06237699: Effects of a Digital Diary on the Psychological Well-being of Former ICU Patients. |
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| Recruiting | N/A | 400 | Europe | Digital ICU diary | Erasmus Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development | Depression, Anxiety, Post Traumatic Stress Disorder, Quality of Life | 08/24 | 05/26 | | |
| Recruiting | N/A | 330 | Europe | DeltaScan, automated 1-channel EEG | Thomas Ottens, Prolira, Dutch Society of Intensive Care | Delirium, Critical Illness, Acute Encephalopathy | 03/25 | 03/26 | | |
| Duyn, Eino B van |
| Recruiting | 2/3 | 358 | Europe | Perioperative systemic therapy, Perioperative CAPOX-bevacizumab, Perioperative FOLFOX-bevacizumab, Perioperative FOLFIRI-bevacizumab, CRS-HIPEC, experimental arm, CRS-HIPEC, control arm | Koen Rovers, Dutch Cancer Society, Comprehensive Cancer Centre The Netherlands, Hoffmann-La Roche | Colorectal Neoplasm, Colorectal Cancer, Colorectal Neoplasms Malignant, Colorectal Carcinoma, Colorectal Adenocarcinoma, Peritoneal Neoplasms, Peritoneal Carcinomatosis, Peritoneal Cancer, Peritoneal Metastases, Peritoneal Neoplasm Malignant Secondary Carcinomatosis, Peritoneal Neoplasm Malignant Secondary | 08/24 | 08/26 | | |
A1Check, NCT05810207: the External Validation of a Machine Learning Model Predicting Colorectal Anastomotic Leakage |
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| Recruiting | N/A | 1000 | Europe | Colorectal resection | Freek Daams, SAS Institute | Anastomotic Leak, Anastomotic Leak Large Intestine, Anastomotic Complication, Anastomotic Leak Rectum | 07/24 | 12/24 | | |
| Wymenga, A |
| Recruiting | 2/3 | 1615 | Europe, Canada | Olaparib, Lynparza, Pelvic external beam radiotherapy, EBRT, Chemotherapy, Cisplatin, Carboplatin, Paclitaxel, Durvalumab, Imfinzi, Medroxyprogesterone Acetate, Progestogen, Megestrol Acetate, Vaginal brachytherapy, Observation | Leiden University Medical Center, Institute Gustave Roussy (sponsor p53abn-RED trial), Leiden University Medical center (sponsor MMRd-GREEN trial), University College London (sponsor NSMP-ORANGE trial), Canadian Clinical Trials Group (sponsor POLEmut-BLUE trial), Dutch Gynaecological Oncology Group, Comprehensive Cancer Centre The Netherlands, Cancer Research UK & UCL Cancer Trials Centre, Dutch Cancer Society, AstraZeneca, National Cancer Institute, France, Canadian Institutes of Health Research (CIHR) | Endometrial Cancer | 01/30 | 01/31 | | |
| Birgelen, Clemens von |
| Recruiting | 3 | 200 | Europe, Canada, US, RoW | Bentracimab (PB2452) Infusion | SFJ Pharmaceuticals, Inc. | Hemorrhage, Urgent Surgery, Invasive Procedure | 08/24 | 08/24 | | |
STOP-IMH, NCT05986968: The Safety of Ticagrelor Monotherapy After Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction and the Effect on Intramyocardial Haemorrhage |
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| Recruiting | N/A | 200 | Europe | Ticagrelor, Aspirin | Radboud University Medical Center | ST Elevation Myocardial Infarction | 07/25 | 07/25 | | |
PIONEER-IV, NCT04923191: The Study is Comparing Clinical Outcomes Between Angiography-derived Physiology Guidance to Usual Care in an All-comers PCI Population With Unrestrictive Use of the HT Supreme Sirolimus-eluting Stent |
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| Recruiting | N/A | 2540 | Europe | Angiography-derived physiology guidance/Local routine diagnostic procedure (LRDP) and usual care | National University of Ireland, Galway, Ireland | Coronary Artery Disease | 01/26 | 01/29 | | |
| Hertog, Heleen M den |
| Recruiting | N/A | 280 | Europe | | Radboud University Medical Center, Synapse bv | Ischemic Stroke, Stroke in the Young, Cardiovascular Diseases, Cerebrovascular Disorders, Embolism and Thrombosis, Thrombophilia, Coagulation | 01/27 | 01/37 | | |
| Mekenkamp, Leonie M |
| Active, not recruiting | 2 | 207 | Europe | Docetaxel, Taxotere, Oxaliplatin, Eloxatin, Capecitabine, Xeloda, gastrectomy, radiotherapy of gastric cancer, Paclitaxel, Carboplatin | The Netherlands Cancer Institute | Gastric Cancer | 04/25 | 03/29 | | |
| Houwelingen, K Gert van |
| Recruiting | 3 | 2499 | Europe, Canada, RoW | zalunfiban, RUC-4, Placebo | CeleCor Therapeutics | ST-elevation Myocardial Infarction (STEMI) | 12/24 | 12/24 | | |
| Person, Contact |
| Recruiting | 3 | 2200 | Europe | Goserelin, Zoladex, Estradiol, FemSeven | University College, London, Medical Research Council | Anemia, Cardiovascular Complications, Hot Flashes, Osteoporosis, Prostate Cancer | 08/21 | 08/21 | | |
| Active, not recruiting | 3 | 1033 | NA | palifermin, rituximab, cyclophosphamide, cytarabine, daunorubicin hydrochloride, etoposide, fludarabine phosphate, imatinib mesylate, melphalan, mercaptopurine, methotrexate, nelarabine, pegaspargase, vincristine sulfate, allogeneic hematopoietic stem cell transplantation, total-body irradiation | University College, London | Leukemia, Mucositis, Oral Complications | 12/24 | 12/25 | | |
STAMPEDE, NCT00268476: Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy |
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| Active, not recruiting | 2/3 | 11992 | Europe | Celecoxib, Celebrex, Docetaxel, Taxotere, Prednisolone, Prednisone, ADT, Androgen Deprivation Therapy, Zoledronic Acid, Zometa, Abiraterone, Zytiga, Radiotherapy to the prostate, RT, Enzalutamide, Xtandi, Metformin, Metformin Hydrochloride, Transdermal Oestradiol, Progynova TS | Medical Research Council | Prostate Cancer | 03/26 | 12/30 | | |
NCT00589017: Tamoxifen in Treating Patients With Metastatic Bladder Cancer That Did Not Respond to Previous Chemotherapy |
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| Recruiting | 2 | 75 | US, Europe | tamoxifen citrate, immunohistochemistry staining method, laboratory biomarker analysis | Baylor College of Medicine | Bladder Cancer | 07/10 | | | |
NCT03412643: Study of Neoadjuvant Chemotherapy Plus Trastuzumab and Pertuzumab in HER2-Negative Breast Cancer Patients With Abnormal HER2 Signaling |
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| Recruiting | 2 | 64 | US | Doxorubicin, Cyclophosphamide, Weekly Paclitaxel, Trastuzumab, Pertuzumab, Celcuity CELx HSF | NSABP Foundation Inc, Celcuity, LLC, Genentech, Inc. | HER2-negative Breast Cancer | 10/23 | 10/23 | | |
| Recruiting | N/A | 30 | Europe | MR LINAC | Royal Marsden NHS Foundation Trust | Prostate Cancer | 08/20 | 08/23 | | |
NCT06032663: Use of PET-MR in Head and Neck Cancer Patients - Diagnostic and Therapeutic Applications |
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| Recruiting | N/A | 10 | Europe | PET-MRI | Sheffield Teaching Hospitals NHS Foundation Trust | Head and Neck Cancer | 10/24 | 10/25 | | |
NCT01840293: Breast Cancer Proteomics and Molecular Heterogeneity |
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| Recruiting | N/A | 1780 | Europe | | Cancer Trials Ireland | Primary Breast Cancer, Recurrent/Metastatic Breast Cancer | 12/29 | 01/38 | | |
| Magni, Federico |
| Recruiting | 3 | 200 | Europe, Canada, US, RoW | Bentracimab (PB2452) Infusion | SFJ Pharmaceuticals, Inc. | Hemorrhage, Urgent Surgery, Invasive Procedure | 08/24 | 08/24 | | |
| Thio, Boony |
| Completed | N/A | 102 | Europe | ADRB2-genotype guided treatment, Randomisation | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Dutch Lung Foundation | Asthma in Children | 10/23 | 10/23 | | |
| Legdeur, MCJC |
| Recruiting | 3 | 564 | Europe | FOLFOX/ FOLFIRI with bevacizumab, - bevacizumab, - irinotecan, - leucovorin, - 5-fluorouracil, - oxaliplatin, FOLFOXIRI with bevacizumab, FOLFOX/ FOLFIRI with panitumumab, - panitumumab | Dutch Colorectal Cancer Group | Colorectal Cancer, Liver Metastases | 08/22 | 07/25 | | |
HOVON 156 AML, NCT04027309 / 2018-000624-33: A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy |
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| Active, not recruiting | 3 | 777 | Europe, RoW | Gilteritinib, ASP2215, Midostaurin, Rydapt | Stichting Hemato-Oncologie voor Volwassenen Nederland, Deutsch-Österreichische Studiengruppe Akute Myeloische Leukämie (AMLSG), Astellas Pharma Global Development, Inc. | Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2 | 12/24 | 06/33 | | |
| Beishuizen, Albertus |
NCT04260789: Reduction of Pathogen Load From the Blood in Septic Patients With Suspected, Life-threatening Bloodstream Infection |
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| Recruiting | N/A | 232 | Europe | Seraph 100,The Microbind Affinity Blood Filter | ExThera Medical Europe BV, ExThera Medical Corporation, Vivantes Klinikum Neukölln | Bloodstream Infection | 03/22 | 08/22 | | |
| Liem, Mike |
PACAP-1, NCT03513705: Impact of Nationwide Enhanced Implementation of Best Practices in Pancreatic Cancer Care |
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| Completed | N/A | 4000 | Europe | Best practices in pancreatic cancer care | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Dutch Cancer Society, Comprehensive Cancer Centre The Netherlands | Carcinoma, Pancreatic Ductal | 07/20 | 07/21 | | |
| Houwelingen, Gert K van |
| Recruiting | N/A | 466 | Europe | No PCI | UMC Utrecht, ZonMw: The Netherlands Organisation for Health Research and Development | Valvular Heart Disease, Aortic Valve Stenosis, Coronary Artery Disease | 11/24 | 08/28 | | |
| Snijders, TJF |
HO171, NCT06014489: A Trial to Assess Cobicistat Boosted Venetoclax in Combination With Azacitidine in Adult Patients With Newly Diagnosed AML |
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| Recruiting | 2 | 142 | Europe | azacitidine, Venetoclax, Cobicistat | Stichting Hemato-Oncologie voor Volwassenen Nederland | AML, Adult | 03/28 | 03/28 | | |
| Fujiwara, Yutaka |
| Recruiting | 3 | 272 | Europe, Canada, Japan, US, RoW | TAS6417, Zipalertinib, CLN-081 | Taiho Oncology, Inc. | Advanced or Metastatic NSCLS With Exon 20 Insertion Mutation | 07/26 | 08/26 | | |
SUNRAY-01, NCT06119581: A Study of LY3537982 Plus Immunotherapy With or Without Chemotherapy in Participants With Non-Small Cell Lung Cancer (NSCLC) With a Change in a Gene Called KRAS G12C |
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| Recruiting | 3 | 1016 | Europe, Canada, Japan, US, RoW | LY3537982, Pembrolizumab, Placebo, Cisplatin, Carboplatin, Pemetrexed | Eli Lilly and Company, Loxo Oncology, Inc. | Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis | 10/26 | 10/29 | | |
NCT05882734: Tuvusertib (M1774) in Combination With Cemiplimab in Participants With Non-Squamous NSCLC (DDRiver NSCLC 322) |
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| Recruiting | 1/2 | 180 | Europe, Japan, US, RoW | M1774, Tuvusertib, Cemiplimab | EMD Serono Research & Development Institute, Inc., Merck KGaA, Darmstadt, Germany | Non-Small Cell Lung Cancer | 08/26 | 09/26 | | |
| Meerwaldt, Robbert |
| Recruiting | N/A | 150 | Europe, RoW | Endurant Chimney Graft Technique | Medtronic Cardiovascular | AAA - Abdominal Aortic Aneurysm | 03/26 | 07/30 | | |
| Mekenkamp, L |
| Recruiting | N/A | 300 | Europe | fecal sample, questionnaire, Blood sample | University Medical Center Groningen | Colorectal Cancer Metastatic | 01/25 | 01/25 | | |
| Recruiting | N/A | 50000 | Europe | | Dutch Colorectal Cancer Group | Colorectal Cancer | 01/50 | 01/51 | | |
| Cornet, Alexander |
CORDEAL, NCT04743232: COVID-19 Resuscitation Plans and Decisions on Escalation and Limitation of Treatment |
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| Suspended | N/A | 200 | Europe | Decision tool for clinicians | Erasmus Medical Center | Covid19, Cardiac Arrest | 12/22 | 01/25 | | |
| Lammers, Natasja |
| Completed | N/A | 102 | Europe | ADRB2-genotype guided treatment, Randomisation | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Dutch Lung Foundation | Asthma in Children | 10/23 | 10/23 | | |
| Willigendael, E |
| Active, not recruiting | 4 | 750 | Europe | ACT guided heparinization, 5 000 IU of heparin | Dijklander Ziekenhuis, ZonMw: The Netherlands Organisation for Health Research and Development, Amsterdam UMC, location VUmc, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Abdominal Aortic Aneurysm, Surgery, Arterial Disease | 05/24 | 11/24 | | |
| Peters, Liesbeth |
| Active, not recruiting | 4 | 59 | Europe | Fentanyl, Fentanyl Matrix, Morphine Retard, Morphine, Placebo patch, Placebo oral capsule | Huib A.M. Kerstjens, Dutch Foundation for Asthma Prevention, Innovatiefonds Zorgverzekeraars | COPD | 05/24 | 08/24 | | |
| Beurden, Wendy van |
| Active, not recruiting | 4 | 59 | Europe | Fentanyl, Fentanyl Matrix, Morphine Retard, Morphine, Placebo patch, Placebo oral capsule | Huib A.M. Kerstjens, Dutch Foundation for Asthma Prevention, Innovatiefonds Zorgverzekeraars | COPD | 05/24 | 08/24 | | |
| Recruiting | N/A | 693 | Europe | Procalcitonin, PCT, Physician's decision | Erasmus Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development | COPD Exacerbation, COPD, Acute Copd Exacerbation | 02/25 | 02/25 | | |
| Geelkerken, RH |
| Recruiting | N/A | 70 | Europe | Endoscopic Coeliac Artery Release (eCAR), Sham Operation | Medisch Spectrum Twente, Medical School Medisch Spectrum Twente, Techmed University of Twente, Erasmus Medical Centre | Mesenteric Ischemia, Median Arcuate Ligament Syndrome, Dunbar Syndrome, Coeliac Artery Compression, Celiac Artery Compression Syndrome | 10/26 | 06/27 | | |
| Recruiting | N/A | 1000 | Europe, US | Thoracic, Abdominal, Custom Device, Illiac Artery | Vascutek Ltd., Bolton Medical | Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Surgery | 11/29 | 11/30 | | |
| Wagenaar, M |
PREDMETH, NCT04314193: Effectiveness of Methotrexate Versus Prednisolone as First-line Therapy for Pulmonary Sarcoidosis |
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| Active, not recruiting | 4 | 138 | Europe | Methotrexate, Prednisolone | Erasmus Medical Center, St. Antonius Hospital, Longfonds | Sarcoidosis, Pulmonary | 07/24 | 07/26 | | |
| Piersma, Djura |
COWBOY, NCT02968303: Induction Therapy With Vemurafenib and Cobimetinib to Optimize Nivolumab and Ipilimumab Therapy |
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| Recruiting | 2 | 200 | Europe | Vemurafenib and Cobimetinib | Radboud University Medical Center, The Netherlands Cancer Institute, Isala | Melanoma, Malignant, of Soft Parts | 10/22 | 10/23 | | |
| Ista, Erwin W |
DIPIC, NCT06237699: Effects of a Digital Diary on the Psychological Well-being of Former ICU Patients. |
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| Recruiting | N/A | 400 | Europe | Digital ICU diary | Erasmus Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development | Depression, Anxiety, Post Traumatic Stress Disorder, Quality of Life | 08/24 | 05/26 | | |
| Opstal, J van |
NCT04612335: Device-based Rate Versus Rhythm Control in Symptomatic Recent-onset Atrial Fibrillation (RACE 9 OBSERVE-AF) |
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| Recruiting | N/A | 490 | Europe | Rate control, Pharmacological or electrical cardioversion | Maastricht University Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development, Dutch Heart Foundation, Netherlands Organisation for Scientific Research | Atrial Fibrillation | 06/24 | 06/25 | | |
| Beishuizen, Bert |
| Completed | N/A | 935 | Europe | PRECISe protocol EN 8g protein/100kcal, PRECISe protocol EN 5g protein/100kcal | Maastricht University Medical Center, Ziekenhuis Oost-Limburg, Zuyderland Medisch Centrum, Gelderse Vallei Hospital, Medisch Spectrum Twente, Centre Hospitalier Universitaire de Liege, Centre Hospitalier Régional de la Citadelle, Universitair Ziekenhuis Brussel, General Hospital Groeninge, Catharina Ziekenhuis Eindhoven | Critical Illness, Intensive Care Unit Acquired Weakness | 10/23 | 10/23 | | |
