University of Massachusetts Worcester
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 11 Trials 
34 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
O'Sullivan, Brian
NCT02565498: Preoperative vs Postoperative IMRT for Extremity/Truncal STS

Active, not recruiting
3
210
Europe, Canada, US
Preoperative intensity modulated radiation therapy, Postoperative intensity modulated radiation therapy
Mount Sinai Hospital, Canada, Princess Margaret Hospital, Canada
Adult Soft Tissue Sarcoma
10/24
05/29
IMPACT, NCT04735952: Improving P. Aeruginosa Detection With Breath-based Diagnostics (-Breath)

Recruiting
N/A
300
Canada, US
University of British Columbia, Arizona State University, Children's Hospital Colorado, National Heart, Lung, and Blood Institute (NHLBI), Cystic Fibrosis Foundation
Cystic Fibrosis
11/24
12/24
Silver, Brian
TWIST, NCT03181360 / 2014-000096-80: Tenecteplase in Wake-up Ischaemic Stroke Trial

Recruiting
3
600
Europe, US, RoW
Tenecteplase, Metalyse, Control
University Hospital of North Norway, UiT The Arctic University of Norway, The Royal Norwegian Ministry of Health, Norwegian Health Association
Ischemic Stroke, Stroke, Acute
12/21
12/22
MOST, NCT03735979: Multi-arm Optimization of Stroke Thrombolysis

Active, not recruiting
3
514
US
Argatroban, Eptifibatide, Placebo
Washington University School of Medicine, National Institute of Neurological Disorders and Stroke (NINDS)
Acute Ischemic Stroke
12/23
04/25
EMPATHY-I, NCT04153942: Earlier Mobilization Post Acute Thrombolysis

Withdrawn
3
694
NA
Mobilization
Brian Silver
Stroke, Stroke, Acute, Stroke, Ischemic
07/24
12/24
EMPATHY-II, NCT04153955: Earlier Mobilization Post Acute Thrombectomy

Withdrawn
3
852
NA
Mobilization
Brian Silver
Stroke, Stroke, Acute, Stroke, Ischemic
07/24
12/24
NCT04689256: Pilot Randomized Controlled Study of the Impact of MedRhythms' MR-010 in Acute Stroke

Terminated
N/A
4
US
MR-010
University of Massachusetts, Worcester, MedRhythms, Inc.
Stroke, Acute
01/23
01/23
OPTIMISTmain, NCT03734640 / ACTRN12619001556134: Optimal Post Tpa-Iv Monitoring in Ischemic Stroke

Recruiting
N/A
7200
Europe, US, RoW
Low-intensity monitoring strategy, Guideline recommended standard monitoring
Craig Anderson, Genentech, Inc., Johns Hopkins University, The George Institute for Global Health, Australia
Acute Ischemic Stroke Patients Receiving Reperfusion Therapy
11/24
03/25
SCORE, NCT05300737: Symptomatic Carotid Outcomes Registry

Recruiting
N/A
114
Canada, US
intensive medical therapy
University of Maryland, Baltimore
Carotid Stenosis, Ischemic Stroke, Transient Ischemic Attack
04/25
10/25
Sleep SMART, NCT03812653: Sleep for Stroke Management and Recovery Trial

Recruiting
N/A
3062
US
CPAP
University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), FusionHealth LLC, Medical University of South Carolina, University of Cincinnati
Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial
11/26
11/26
Cerny, Jan
AIM4CML, NCT04666259: Asciminib in Monotherapy for Chronic Myeloid Leukemia in Chronic Phase (CML-CP) With and Without T315I Mutation

Completed
3
56
US
ABL001
Novartis Pharmaceuticals
Chronic Myelogenous Leukemia - Chronic Phase
06/23
06/24
NCT01351545: A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

Recruiting
N/A
99999
US
A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs)
Center for International Blood and Marrow Transplant Research, National Marrow Donor Program
Hematologic Malignancies, Inherited Disorders of Metabolism, Inherited Abnormalities of Platelets, Histiocytic Disorders, Acute Myelogenous Leukemia (AML or ANLL), Acute Lymphoblastic Leukemia (ALL), Other Acute Leukemia, Chronic Myelogenous Leukemia (CML), Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases, Other Leukemia, Hodgkin Lymphoma, Non-hodgkin Lymphoma, Multiple Myeloma/ Plasma Cell Disorder (PCD), Inherited Abnormalities of Erythrocyte Differentiation or Function, Disorders of the Immune System, Autoimmune Diseases, Severe Aplastic Anemia
10/41
10/41
NCT01174615: Collection of Blood and/or Bone Marrow for Investigation and Characterization of Normal and Abnormal Cell Growth

Withdrawn
N/A
1000
US
University of Massachusetts, Worcester
Leukemia
12/99
12/00
Muehlschlegel, Susanne
NCT05671874: Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI

Recruiting
N/A
50
US
Web/mobile/tablet-based digital decision aid + communication (DA+C) tool
University of Massachusetts, Worcester, Worcester Polytechnic Institute, National Institutes of Health (NIH), National Institute of Nursing Research (NINR), Johns Hopkins University
Hemorrhagic Stroke, Intracerebral, Acute Ischemic Stroke, Traumatic Brain Injury
06/25
09/25
BOOST3, NCT03754114: Brain Oxygen Optimization in Severe TBI, Phase 3

Recruiting
N/A
1094
Canada, US
ICP + PbtO2 guided management strategy, ICP guided management strategy
University of Michigan, National Institute of Neurological Disorders and Stroke (NINDS), University of Washington, University of Pennsylvania, University of Pittsburgh, Medical University of South Carolina
Brain Injuries, Traumatic
11/27
11/27
Kakouros, Nikolaos
ECLIPSE, NCT03108456: Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The Trial

Active, not recruiting
N/A
2005
US
Orbital Atherectomy, Balloon
Abbott Medical Devices, Cardiovascular Research Foundation, New York
Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction
06/24
06/25
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study

Recruiting
N/A
400
Europe, US, RoW
AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy
Ancora Heart, Inc.
Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
12/26
12/30
SAVI-AoS, NCT04514250: Stress Aortic Valve Index for Assessing Risk in Aortic Valve Stenosis Patients

Active, not recruiting
N/A
52
Europe, US
Catharina Ziekenhuis Eindhoven
Aortic Valve Stenosis
10/24
10/28
Bodkin, Noelle
PICASSO, NCT05611242: Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial

Recruiting
3
404
US
MT+CAS with IV-AP, Thrombectomy, MT+CAS with PO-AP, MT+CAT with PO-AP
Mercy Health Ohio
Acute Ischemic Stroke
03/26
05/27
ENDOLOW, NCT04167527: Endovascular Therapy for Low NIHSS Ischemic Strokes

Recruiting
2/3
200
Europe, Canada, US
Immediate mechanical thrombectomy(iMT) using EmboTrap Revascularization Device, EmboTrap III, Initial medical management (iMM)
Emory University, University of Calgary, University of Cincinnati, Heidelberg University, Children's Hospital Medical Center, Cincinnati
Cerebral Ischemia
12/24
12/24
NCT05018650: A Randomized, Controlled Trial to Evaluate the Safety and Effectiveness of the Route 92 Medical Reperfusion System (SUMMIT MAX)

Active, not recruiting
N/A
250
US, RoW
Route 92 Medical Reperfusion System
Route 92 Medical, Inc.
Acute Ischemic Stroke
06/24
06/24
WEB PAS, NCT04839705: Post Approval Study - Evaluate the Long-Term Safety and Effectiveness of the WEB Device

Recruiting
N/A
180
US
WEB
Microvention-Terumo, Inc.
Wide Neck Bifurcation Intracranial Aneurysms
12/25
12/29
CREST-2, NCT02089217: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

Active, not recruiting
N/A
2486
Europe, Canada, US, RoW
Carotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA, Intensive Medical Management - no CAS
Thomas G. Brott, M.D., National Institute of Neurological Disorders and Stroke (NINDS)
Carotid Stenosis
02/26
02/26
NCT04057352: Citadel Embolization Device Study

Recruiting
N/A
150
US
Citadel Embolization Device
Stryker Neurovascular
Unruptured Wide-neck Aneurysms
06/26
06/26
Papalia, Susan
ECLIPSE, NCT03108456: Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The Trial

Active, not recruiting
N/A
2005
US
Orbital Atherectomy, Balloon
Abbott Medical Devices, Cardiovascular Research Foundation, New York
Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction
06/24
06/25
Gerber, Jonathan
STIMULUS MDS-US, NCT04878432: : Sabatolimab Added to HMA in Higher Risk MDS

Completed
2
39
US
MBG453, sabatolimab, Azacitidine, Decitabine, INQOVI (oral decitabine)
Novartis Pharmaceuticals
Myelodysplastic Syndrome (MDS)
09/23
09/24
NCT04764474: A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH

Recruiting
1
75
Europe, US
HMPL-306
Hutchmed
Isocitrate Dehydrogenase Gene Mutation
09/24
06/25
NCT05155709 / 2021-001165-21: A Study of Siremadlin in Combination With Venetoclax Plus Azacitidine in Adult Participants With Acute Myeloid Leukemia (AML) Who Are Ineligible for Chemotherapy.

Terminated
1
14
Europe, US, RoW
siremadlin, HDM201, venetoclax, azacitidine
Novartis Pharmaceuticals, Novartis Pharma AG
Acute Myeloid Leukemia
04/24
04/24
NCT04445207: Experimental Expanded Access Treatment With Convalescent Plasma for the Treatment of Patients With COVID-19

No Longer Available
N/A
US
Convalescent Plasma
Jonathan Gerber
COVID, Sars-CoV2, Corona Virus Infection
 
 
Agrillo, Alexandra
NCT05561751: Ph2, Study to Assess the Safety and Efficacy of GPC 100 and Propranolol With and Without G-CSF for the Mobilization of Stem Cells in Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant

Recruiting
2
40
US
GPC-100, Propranolol, G-CSF
GPCR Therapeutics, Inc.
Multiple Myeloma
03/25
06/25
Toke, Madhavi
EMBER-4, NCT05514054: A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer

Recruiting
3
6000
Europe, Canada, Japan, US, RoW
Imlunestrant, LY3484356, Tamoxifen, Anastrozole, Letrozole, Exemestane
Eli Lilly and Company
Breast Neoplasms
10/27
03/32
CompassHER2 RD, NCT04457596: T-DM1 and Tucatinib Compared with T-DM1 Alone in Preventing Relapses in People with High Risk HER2-Positive Breast Cancer, the Trial

Calendar Jan 2028 - Dec 2028: From CompassHER2 RD trial in combination with Kadcyla for HER2+ breast cancer
Recruiting
3
1031
Canada, US
Trastuzumab Emtansine, Placebo Administration, Tucatinib, Questionnaire Administration, Quality-of-Life Assessment
Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI), Seagen Inc.
Anatomic Stage IA Breast Cancer AJCC V8, Anatomic Stage II Breast Cancer AJCC V8, Anatomic Stage IIA Breast Cancer AJCC V8, Anatomic Stage IIB Breast Cancer AJCC V8, Anatomic Stage III Breast Cancer AJCC V8, Anatomic Stage IIIA Breast Cancer AJCC V8, Anatomic Stage IIIB Breast Cancer AJCC V8, Anatomic Stage IIIC Breast Cancer AJCC V8, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Multifocal Breast Carcinoma, Prognostic Stage I Breast Cancer AJCC V8, Prognostic Stage IA Breast Cancer AJCC V8, Prognostic Stage IB Breast Cancer AJCC V8, Prognostic Stage II Breast Cancer AJCC V8, Prognostic Stage IIA Breast Cancer AJCC V8, Prognostic Stage IIB Breast Cancer AJCC V8, Prognostic Stage III Breast Cancer AJCC V8, Prognostic Stage IIIA Breast Cancer AJCC V8, Prognostic Stage IIIB Breast Cancer AJCC V8, Prognostic Stage IIIC Breast Cancer AJCC V8, Synchronous Bilateral Breast Carcinoma
01/28
05/35
Nickerson, Jenna
ECLIPSE, NCT03108456: Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The Trial

Active, not recruiting
N/A
2005
US
Orbital Atherectomy, Balloon
Abbott Medical Devices, Cardiovascular Research Foundation, New York
Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction
06/24
06/25
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study

Recruiting
N/A
400
Europe, US, RoW
AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy
Ancora Heart, Inc.
Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
12/26
12/30

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