UNC Comprehensive Sickle Cell Center Trials

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Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

Ford, James M

PINES, NCT03939637: Eltrombopag Vs Standard Front Line Management for Newly Diagnosed Immune Thrombocytopenia (ITP) in Children

Active, not recruiting

122

Eltrombopag, Steroids, IVIG, Rho(D) Immune Globulin

Baylor College of Medicine, Boston Children's Hospital, University of California, San Francisco

Immune Thrombocytopenia

03/25

12/25

NCT05554341: Testing the Use of Nilotinib and Paclitaxel as a Treatment for Patients With Prior Taxane Treatment, A ComboMATCH Treatment Trial

Active, not recruiting

Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nilotinib Hydrochloride Monohydrate, AMN 107, AMN-107, AMN107, Nilotinib Monohydrochloride Monohydrate, Tasigna, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat

National Cancer Institute (NCI)

Metastatic Malignant Solid Neoplasm, Refractory Malignant Solid Neoplasm

07/25

ComboMATCH, NCT05554380: Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With PTEN/AKT Mutations, A Treatment Trial

Recruiting

Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Ipatasertib, GDC 0068, GDC-0068, GDC0068, RG 7440, RG-7440, RG7440, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat

National Cancer Institute (NCI)

Locally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Unresectable Malignant Solid Neoplasm

08/25

NCT05564377: Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Recruiting

2900

Alpelisib, BYL 719, BYL-719, BYL719, Phosphoinositide 3-kinase Inhibitor BYL719, Piqray, VIJOICE, Binimetinib, ARRY 162, ARRY 438162, ARRY-162, ARRY-438162, ARRY162, ARRY438162, MEK 162, MEK-162, MEK162, Mektovi, Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Aspiration, Bone Scan, Bone Scintigraphy, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Echocardiography, EC, Fluorouracil, 5 Fluorouracil, 5 Fluorouracilum, 5 FU, 5-Fluoro-2,4(1H, 3H)-pyrimidinedione, 5-Fluorouracil, 5-Fluracil, 5-Fu, 5FU, AccuSite, Carac, Fluoro Uracil, Fluouracil, Flurablastin, Fluracedyl, Fluracil, Fluril, Fluroblastin, Ribofluor, Ro 2-9757, Ro-2-9757, Fulvestrant, Faslodex, Faslodex(ICI 182,780), ICI 182,780, ICI 182780, ICI-182780, ICI182780, ZD 9238, ZD-9238, ZD9238, Ipatasertib, GDC 0068, GDC-0068, GDC0068, RG 7440, RG-7440, RG7440, Leucovorin, Folinic acid, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, Gated Heart Pool Scan, MUGA, MUGA Scan, Multi-Gated Acquisition Scan, Radionuclide Ventriculogram Scan, Radionuclide Ventriculography, RNV Scan, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Mutation Carrier Screening, Neratinib Maleate, 2-Butenamide, N-(4-((3-chloro-4-(2-pyridinylmethoxy)phenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate (1:1), HKI-272 Maleate, NERATINIB MALEATE ANHYDROUS, Nerlynx, Nilotinib Hydrochloride Monohydrate, AMN 107, AMN-107, AMN107, Nilotinib Monohydrochloride Monohydrate, Tasigna, Olaparib, AZD 2281, AZD-2281, AZD2281, KU 0059436, KU-0059436, KU0059436, Lynparza, Olanib, Olaparix, PARP Inhibitor AZD2281, Oxaliplatin, 1-OHP, Ai Heng, Aiheng, Dacotin, Dacplat, Diaminocyclohexane Oxalatoplatinum, Eloxatin, Eloxatine, Elplat, JM 83, JM-83, JM83, Oxalatoplatin, Oxalatoplatinum, RP 54780, RP-54780, RP54780, SR 96669, SR-96669, SR96669, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Palbociclib, 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-8h-pyrido(2,3-d)pyrimidin-7-one, Ibrance, PD 0332991, PD 332991, PD 991, PD-0332991, PD0332991, Panitumumab, ABX-EGF, ABX-EGF Monoclonal Antibody, ABX-EGF, Clone E7.6.3, E7.6.3, Human IgG2K Monoclonal Antibody, MoAb ABX-EGF, MoAb E7.6.3, Monoclonal Antibody ABX-EGF, Monoclonal Antibody E7.6.3, Vectibix, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT, Selumetinib Sulfate, AZD-6244 Hydrogen Sulfate, AZD6244 Hydrogen Sulfate, AZD6244 Hydrogen Sulphate, Koselugo, Selumetinib Sulphate, Sotorasib, AMG 510, AMG-510, AMG510, Lumakras, Lumykras

National Cancer Institute (NCI)

Advanced Malignant Solid Neoplasm, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Locally Advanced Malignant Solid Neoplasm, Malignant Female Reproductive System Neoplasm, Metastatic HER2-Negative Breast Carcinoma, Metastatic Malignant Solid Neoplasm, Recurrent Endometrial Carcinoma, Recurrent Fallopian Tube Carcinoma, Recurrent Malignant Female Reproductive System Neoplasm, Recurrent Malignant Solid Neoplasm, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma, Unresectable HER2-Negative Breast Carcinoma, Unresectable Malignant Solid Neoplasm

07/30

NCT05132868: Assessments of Genetic Counseling Augmented With an Educational Video or Pamphlet Versus Traditional Counseling

Completed

N/A

Educational video and pamphlet, Traditional genetic counseling

Stanford University

Quality, Prostate Cancer, Gastrointestinal Cancer, Gynecologic Cancer, Ovarian Cancer, Pancreatic Cancer

06/23

NCT02215928: Genomic Profiling in Recommending Treatment for Patients With Metastatic Solid Tumors

Recruiting

N/A

100

mutation analysis, cytology specimen collection procedure, cytologic sampling, laboratory biomarker analysis

Stanford University

Unspecified Adult Solid Tumor, Protocol Specific

12/25

NCT01034033: Genetic & Pathological Studies of BRCA1/BRCA2: Associated Tumors & Blood Samples

Recruiting

N/A

3300

Stanford University, Breast Cancer Research Foundation, Susan G. Komen Breast Cancer Foundation

Breast Cancer, Ovarian Cancer, Gynecologic Cancers, Ovarian/Peritoneal/Fallopian Cancer

01/99

NCT01048281: Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma

Recruiting

N/A

100

Blood draw, Tissue tumor biopsy

Stanford University, National Institutes of Health (NIH)

Stomach Cancer, Gastro-Esophageal(GE) Junction Cancer, Gastric (Stomach) Cancer, Esophageal Cancer, Gastrointestinal Stromal Tumor (GIST)

01/99

Ataga, Kenneth

NCT03277547: Kidney Function in Sickle Cell Anemia

Active, not recruiting

N/A

300

Kenneth Ataga MD, Ohio State University, University of North Carolina

Sickle Cell Disease, Kidney Failure, Chronic

06/25

12/25

NCT04380610: Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia

Recruiting

N/A

400

iohexol GFR

University of Alabama at Birmingham, National Heart, Lung, and Blood Institute (NHLBI)

Sickle Cell Disease, Renal Disease, Glomerular Disease

05/25

PREMIER, NCT05214105: The Predictive Capacity of Machine Learning Models for Progressive Kidney Disease in Individuals With Sickle Cell Anemia

Recruiting

N/A

400

Biospecimen/DNA collection and analysis

University of Tennessee, National Heart, Lung, and Blood Institute (NHLBI), University of Illinois at Chicago, University of Memphis, University of North Carolina, Charlotte, Wake Forest University, University of North Carolina, Chapel Hill

Sickle Cell Disease, Kidney Diseases, Chronic

01/26

SCCRIP, NCT02098863: Sickle Cell Clinical Research and Intervention Program

Recruiting

N/A

10000

St. Jude Children's Research Hospital, University of Memphis School of Public Health, Le Bonheur Children's Hospital, University of Alabama at Birmingham, Washington University School of Medicine, UTHSC-ORNL Center in Biomedical Informatics, University of Washington, Medical College of Wisconsin, University of Tennessee, Children's Hospital of Philadelphia, National Heart, Lung, and Blood Institute (NHLBI), Vanderbilt University School of Medicine, Baylor College of Medicine

Sickle Cell Disease

12/44

Little, Jane

SCD-CARRE, NCT04084080: Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial

Recruiting

160

Europe, US, RoW

Red Blood Cell, Red blood cell (RBC), Standard of care

University of Pittsburgh, National Heart, Lung, and Blood Institute (NHLBI)

Sickle Cell Disease

05/26

NCT03704922: Age of Blood in Sickle Cell Transfusion

Completed

2/3

Transfusion

University of North Carolina, Chapel Hill, National Heart, Lung, and Blood Institute (NHLBI)

Sickle Cell Disease

01/24

AUNT, NCT06071377: Achieving Understanding of the Natural History of Sickle Cell Trait

Recruiting

N/A

1000

Biologic Specimen Collection

National Alliance for Sickle Cell Centers, Beam Therapeutics Inc.

Sickle Cell Trait

04/25



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