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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
Soares, Jair C
SMART-BD, NCT06433635: Sequential Multiple Assignment Randomized Trial for Bipolar Depression	Not yet recruiting	4	2726	Canada, US	Cariprazine, Vraylar, Aripiprazole/Escitalopram combination, Abilify/ Lexapro, Quetiapine, Seroquel, Lurasidone, Latuda	Massachusetts General Hospital, Patient-Centered Outcomes Research Institute	Bipolar I Disorder, Depression	02/30	02/30
NCT05624268: Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD	Recruiting	3	255	US	Psilocybin, COMP360	COMPASS Pathways	Treatment Resistant Depression	02/25	02/26
NCT05169710 / 2021-002126-24: A Clinical Study of an Investigational Drug for the Treatment of Major Depressive Episode Associated With Bipolar I Disorder.	Terminated	3	83	Europe, Canada, Japan, US	SEP-4199 CR 200 mg, SEP-4199 CR 400 mg, Placebo	Sumitomo Pharma America, Inc., Sunovion Pharmaceuticals Inc.	Depressive Episodes, Bipolar I Depression	10/23	10/23
ENLIGHTEN, NCT05113771: A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment-Resistant Depression	Completed	2	197	Canada, US	Liafensine, Placebo	Denovo Biopharma LLC	Treatment Resistant Depression	02/24	03/24
NCT06706232: Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression	Not yet recruiting	2	10	US	Psilocybin, Therapeutic Support	The University of Texas Health Science Center, Houston, Anne and Don Fizer Foundation	Bipolar II Disorder, Depression, Bipolar, Suicidality	01/27	01/27
NCT03522545: Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression	Recruiting	1	30	US	Allogeneic Bone Marrow Derived Multipotent Mesenchymal Stromal Cells (MSCs), Placebo	The University of Texas Health Science Center, Houston	Treatment-resistant Bipolar Depression	12/24	12/24
PBR, NCT02360267: Pediatric Bipolar Registry	Completed	N/A	334	US		The University of Texas Health Science Center, Houston	Bipolar Disorder, Depression, Mania, Psychosis	05/16	02/19
GHAPBR, NCT06665984: Greater Houston Area Pediatric Bipolar Registry	Recruiting	N/A	1000	US		The University of Texas Health Science Center, Houston, John S. Dunn Foundation	Pediatric Bipolar Disorder	12/27	12/46
NCT05194332: Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive Function	Not yet recruiting	N/A	24	US	LIFUP sonication to the amygdala	The University of Texas Health Science Center, Houston	Depressive Disorder, Major	01/28	01/28
NCT02046330: Deep Brain Stimulation (DBS) Therapy for Treatment Resistant Depression	Active, not recruiting	N/A	16	US	Deep Brain Stimulation Model 3387 Model 3389, Medtronic Neuromodulation	The University of Texas Health Science Center, Houston, Medtronic	Major Depressive Disorder, Treatment Resistant Depression	04/27	04/27
NCT05240352: Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression	Recruiting	N/A	45	US	active tDCS, sham tDCS	The University of Texas Health Science Center, Houston, Milken Institute	Anhedonia	12/24	12/25