| Fischer, Urs |
MOSES, NCT03961334: MidregiOnal Proatrial Natriuretic Peptide to Guide SEcondary Stroke Prevention |
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| Recruiting | 3 | 620 | Europe | Dabigatran, Pradaxa, Apixaban, Eliquis, Edoxaban, Lixiana, Aspirin, Aspirin cardio, Clopidogrel | University of Zurich, Swiss National Science Foundation | Stroke, Ischemic | 01/25 | 01/26 | | |
TECNO, NCT05499832: Safety and Efficacy of Intra-arterial Tenecteplase for Noncomplete Reperfusion of Intracranial Occlusions |
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| Recruiting | 3 | 156 | Europe | Tenecteplase | Insel Gruppe AG, University Hospital Bern | Ischemic Stroke | 07/25 | 10/25 | | |
| Completed | N/A | 410 | Europe, Canada | Stent-retriever thrombectomy with revascularization device of the Solitaire™ type, Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA) | Insel Gruppe AG, University Hospital Bern, Medtronic | Ischemic Stroke | 05/21 | 08/21 | | |
| Completed | N/A | 1282 | Europe, US | | Boston Medical Center, Heidelberg University | Stroke, Acute Ischemic | 05/22 | 01/23 | | |
ELAN, NCT03148457: Early Versus Late Initiation of Direct Oral Anticoagulants in Post-ischaemic Stroke Patients With Atrial fibrillatioN (): an International, Multicentre, Randomised-controlled, Two-arm, Assessor-blinded Trial |
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| Completed | N/A | 2013 | Europe, Japan, RoW | Early treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®), Late treatment with Rivaroxaban (Xarelto®), Dabigatran (Pradaxa®), Apixaban (Eliquis®) or Edoxaban (Lixiana®) | Insel Gruppe AG, University Hospital Bern | Ischaemic Stroke | 12/22 | 05/23 | | |
| Completed | N/A | 201 | Europe | Decompressive craniectomy (DC) and best medical treatment, Best medical treatment | Insel Gruppe AG, University Hospital Bern | Cerebral Hemorrhage | 10/23 | 05/24 | | |
HemEXPLO, NCT05504941: Detection of an Endovascular Treatment Target in Patients With an Acute, Spontaneous Intracerebral Hemorrhage |
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| Recruiting | N/A | 15 | Europe | Diagnostic, cerebral Digital Subtraction Angiography (DSA) | University Hospital, Basel, Switzerland, Clinical Trial Unit, University Hospital Basel, Switzerland | Intracerebral Hemorrhage, Nontraumatic Intracerebral Hemorrhage | 12/24 | 01/25 | | |
NCT04805177: Early Minimally Invasive Image Guided Endoscopic Evacuation of Intracerebral Haemorrhage |
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| Completed | N/A | 11 | Europe | hematoma evacuation | University Hospital, Basel, Switzerland, Swiss Heart Foundation | Intracerebral Hemorrhage (ICH) | 12/23 | 07/24 | | |
DISTAL, NCT05029414: EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke |
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| Active, not recruiting | N/A | 543 | Europe, RoW | Endovascular Therapy | University Hospital, Basel, Switzerland, Swiss National Fund for Scientific Research, Stryker Neurovascular, Penumbra Inc., Medtronic, Phenox GmbH, Rapid Medical, Gottfried und Julia Bangerter-Rhyner-Stiftung | Acute Ischemic Stroke | 10/24 | 06/25 | | |
| Recruiting | N/A | 200 | Europe | Early minimally invasive image guided endoscopic hematoma evacuation, Best medical treatment (BMT) | University Hospital, Basel, Switzerland, Swiss National Science Foundation, University Hospital, Geneva, Cantonal Hospital of St. Gallen, Ospedale Regionale di Lugano, Centre Hospitalier Universitaire Vaudois, Hôpital du Valais, University Hospital, Zürich, Kantonsspital Winterthur KSW, Insel Gruppe AG, University Hospital Bern, Luzerner Kantonsspital | Intracerebral Haemorrhage | 12/28 | 12/29 | | |
CBI-Registry, NCT05685069: Prevalence of Attributable Etiology and Modifiable Stroke Risk Factors in Patients With Covert Brain Infarctions |
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| Recruiting | N/A | 230 | Europe | | Insel Gruppe AG, University Hospital Bern | Silent Stroke, Silent Cerebral Infarct, Covert Brain Infarct, Covert Brain Infarction, Lacune, Silent Brain Infarction | 12/25 | 08/26 | | |
| Seiffge, David |
| Active, not recruiting | 4 | 948 | Europe, Canada, US, RoW | Edoxaban, Lixiana, Savaysa, Non-anticoagulant medical therapy | Population Health Research Institute | Intracranial Hemorrhages, Atrial Fibrillation | 04/26 | 10/26 | | |
MOSES, NCT03961334: MidregiOnal Proatrial Natriuretic Peptide to Guide SEcondary Stroke Prevention |
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| Recruiting | 3 | 620 | Europe | Dabigatran, Pradaxa, Apixaban, Eliquis, Edoxaban, Lixiana, Aspirin, Aspirin cardio, Clopidogrel | University of Zurich, Swiss National Science Foundation | Stroke, Ischemic | 01/25 | 01/26 | | |
| Recruiting | N/A | 200 | Europe | | Insel Gruppe AG, University Hospital Bern | Intra Cerebral Hemorrhage | 04/26 | 04/26 | | |
MRI-PRO-SVD, NCT05773235: MRI-markers to Monitor Small Vessel Disease Dynamics in the Prognosis of Small Vessel Disease-associated, Cerebrovascular Events |
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| Recruiting | N/A | 60 | Europe | Combined 3- and 7 Tesla-MRI | University Hospital Inselspital, Berne | Intracerebral Hemorrhage, CAA - Cerebral Amyloid Angiopathy, Cerebral Small Vessel Diseases | 06/24 | 06/24 | | |
| Not yet recruiting | N/A | 50 | Europe | MAX-ICH care bundle, Standard of care | Insel Gruppe AG, University Hospital Bern | Intra Cerebral Hemorrhage | 05/26 | 05/26 | | |
| Recruiting | N/A | 900 | Europe | | University Hospital Inselspital, Berne | Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease, Cadasil, CAA - Cerebral Amyloid Angiopathy | 11/30 | 11/30 | | |
| Arnold, Marcel |
NCT02864953 / 2017-004854-41: Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction |
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| Terminated | 3 | 535 | Europe, Canada, Japan, US, RoW | BIIB093, glibenclamide, glibenclamide intravenous (IV), glyburide, CIRARA, Placebo | Remedy Pharmaceuticals, Inc. | Brain Edema, Stroke, Acute | 08/23 | 08/23 | | |
| Recruiting | N/A | 500 | Europe, Japan | No study-specific intervention | Insel Gruppe AG, University Hospital Bern, Swiss Heart Foundation, Cervical Artery Dissections and Ischemic Stroke Patients - Consortium | Cerebrovascular Disorders, Vascular: Intracranial, Intimal Dissection, Stroke | 11/26 | 11/27 | | |
